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https://www.readbyqxmd.com/read/28933958/transplantation-of-human-corneal-endothelial-cells-cultured-on-bio-engineered-collagen-vitrigel-in-a-rabbit-model-of-corneal-endothelial-dysfunction
#1
Junko Yoshida, Seiichi Yokoo, Ayumi Oshikata-Miyazaki, Shiro Amano, Toshiaki Takezawa, Satoru Yamagami
PURPOSE: To evaluate the effect of transplanting bioengineered corneal endothelial grafts in a rabbit model of corneal endothelial failure. METHODS: Human corneal endothelial cells (HCECs) were seeded on a vitrigel carrier. After Descemet's membrane was removed from the eyes of rabbits, transplantation was done with a vitrigel/HCEC graft or vitrigel alone without cells, or the eyes were left untreated. Slit lamp examinations and measurement of the central corneal thickness (CCT) were performed for 14 days postoperatively...
September 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28931714/early-career-researchers-an-interview-with-kakani-katija
#2
(no author information available yet)
Kakani Katija is a Principal Engineer at the Monterey Bay Aquarium Research Institute, USA, where she designs and builds instrumentation to study marine invertebrate ecomechanics. She received her Bachelor's degree in Aeronautics and Astronautics from the University of Washington, USA, before moving to the California Institute of Technology, USA, for her Master's degree in Aeronautics with Morteza Gharib and PhD in Bioengineering in the laboratory of John Dabiri, completed in 2010. Katija was recognised as a National Geographic Emerging Explorer in 2011 and has given presentations at TEDYouth and TEDWomen...
September 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28929219/3d-printing-for-clinical-application-in-otorhinolaryngology
#3
REVIEW
Nongping Zhong, Xia Zhao
Three-dimensional (3D) printing is a promising technology that can use a patient's image data to create complex and personalized constructs precisely. It has made great progress over the past few decades and has been widely used in medicine including medical modeling, surgical planning, medical education and training, prosthesis and implants. Three-dimensional (3D) bioprinting is a powerful tool that has the potential to fabricate bioengineered constructs of the desired shape layer-by-layer using computer-aided deposition of living cells and biomaterials...
September 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28922975/bioengineered-submucosal-organoids-for-in-vitro-modeling-of-colorectal-cancer
#4
Mahesh Devarasetty, Aleksander Skardal, Kyle Cowdrick, Frank Marini, Shay Soker
The physical nature of the tumor microenvironment significantly impacts tumor growth, invasion and response to drugs. Most in vitro tumor models are designed to study the effects of extracellular matrix (ECM) stiffness on tumor cells, while not addressing the effects of ECM's specific topography. In this study we bioengineered submucosal organoids, using primary smooth muscle cells (SMCs) embedded in collagen I (Col I) hydrogel, which produce aligned and parallel fiber topography similar to those found in vivo...
September 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28922323/face-graft-scaffold-production-in-a-rat-model
#5
Jérôme Duisit, Hadrien Amiel, Giuseppe Orlando, Adeline Dedriche, Catherine Behets, Pierre Gianello, Benoît Lengelé
BACKGROUND: As a route towards face bioengineering, our group previously reported the production of a complete scaffold production by perfusion-decellularization of a porcine ear subunit graft and partial recellularization. In order to extend the scaffold to the whole face and to down-scale it, we applied our findings to a rodent hemi-facial graft model. METHODS: After euthanasia, seven full-thickness rat hemi-face grafts were harvested with the CCA and the EJV as pedicle, and cannulated...
September 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28919737/bacterial-membrane-vesicles-as-novel-nanosystems-for-drug-delivery
#6
REVIEW
Sapna Jain, Jonathan Pillai
Bacterial membrane vesicles (BMVs) are closed spherical nanostructures that are shed naturally and ubiquitously by most bacterial species both in vivo and in vitro. Researchers have elucidated their roles in long-distance transport of a wide array of cargoes, such as proteins, toxins, antigens, virulence factors, microbicidal agents and antibiotics. Given that these natural carriers are important players in intercellular communication, it has been hypothesized that they are equally well attuned for transport and delivery of exogenous therapeutic cargoes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919507/tissue-engineered-magnetic-cell-sheet-patches-for-advanced-strategies-in-tendon-regeneration
#7
Ana I Gonçalves, Márcia T Rodrigues, Manuela E Gomes
Tendons are powerful 3D biomechanically structures combining a few cells in an intrincated and highly hierarchical niche environment. When tendon homeostasis is compromised, restoration of functionality upon injury is limited and requires alternatives to current augmentation or replacement strategies. Cell sheet technologies are a powerful tool for the fabrication of living extracellular-rich patches towards regeneration of tenotopic defects. Thus, we originally propose the development of magnetically responsive tenogenic patches through magnetic cell sheet (magCSs) technology that enable the remote control upon implantation of the tendon-mimicking constructs...
September 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28915407/differentiation-and-sarcomere-formation-in-skeletal-myocytes-directly-prepared-from-human-induced-pluripotent-stem-cells-using-a-sphere-based-culture
#8
Saowanee Jiwlawat, Eileen Lynch, Jennifer Glaser, Ivy Smit-Oistad, Jeremy Jeffrey, Jonathan M Van Dyke, Masatoshi Suzuki
Human induced-pluripotent stem cells (iPSCs) are a promising resource for propagation of myogenic progenitors. Our group recently reported a unique protocol for the derivation of myogenic progenitors directly (without genetic modification) from human pluripotent cells using free-floating spherical culture. Here we expand our previous efforts and attempt to determine how differentiation duration, culture surface coatings, and nutrient supplements in the medium influence progenitor differentiation and formation of skeletal myotubes containing sarcomeric structures...
August 1, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28914208/a-systematic-review-of-clinical-studies-investigating-mesenchymal-stem-cells-for-fracture-non-union-and-bone-defects
#9
Kieran Killington, Reza Mafi, Pouya Mafi, Wasim Khan
Fracture non-union is a significant problem with a wide demographic and massive socioeconomic elements, as well as the clinical difficulties it presents. Conventional treatments with autograft and allograft bone grafting pose serious difficulties, thus, it is necessary to develop novel techniques with our ever increasing knowledge of bioengineering using natural materials. Papers were searched from a variety of sources, not limited to English-language studies or only published papers. Papers had to meet the definition of fracture non-union or bone defect and had to be clinical trials, using human MSCs...
September 15, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28912891/bioengineering-of-artificial-antigen-presenting-cells-and-lymphoid-organs
#10
REVIEW
Chao Wang, Wujin Sun, Yanqi Ye, Hunter N Bomba, Zhen Gu
The immune system protects the body against a wide range of infectious diseases and cancer by leveraging the efficiency of immune cells and lymphoid organs. Over the past decade, immune cell/organ therapies based on the manipulation, infusion, and implantation of autologous or allogeneic immune cells/organs into patients have been widely tested and have made great progress in clinical applications. Despite these advances, therapy with natural immune cells or lymphoid organs is relatively expensive and time-consuming...
2017: Theranostics
https://www.readbyqxmd.com/read/28904949/bioengineering-materials-in-dental-application
#11
EDITORIAL
Wei-Jen Chang, Abe Shinichi, Shinji Kamakura, Ren-Yeong Huang, Jung-Wei Chen
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28898758/modular-flow-chamber-for-engineering-bone-marrow-architecture-and-function
#12
Christian A Di Buduo, Paolo M Soprano, Lorenzo Tozzi, Stefania Marconi, Ferdinando Auricchio, David L Kaplan, Alessandra Balduini
The bone marrow is a soft, spongy, gelatinous tissue found in the hollow cavities of flat and long bones that support hematopoiesis in order to maintain the physiologic turnover of all blood cells. Silk fibroin, derived from Bombyx mori silkworm cocoons, is a promising biomaterial for bone marrow engineering, because of its tunable architecture and mechanical properties, the capacity of incorporating labile compounds without loss of bioactivity and demonstrated ability to support blood cell formation. In this study, we developed a bone marrow scaffold consisting of a modular flow chamber made of polydimethylsiloxane, holding a silk sponge, prepared with salt leaching methods and functionalized with extracellular matrix components...
August 8, 2017: Biomaterials
https://www.readbyqxmd.com/read/28892571/regenerative-immunology-the-immunological-reaction-to-biomaterials
#13
Paolo Cravedi, Samira Farouk, Andrea Angeletti, Lauren Edgar, Riccardo Tamburrini, Jerome Dusuit, Laura Perin, Giuseppe Orlando
Regenerative medicine promises to meet two of the most urgent needs of modern organ transplantation, namely immunosuppression-free transplantation and an inexhaustible source of organs. Ideally, bioengineered organs would be manufactured from a patient's own biomaterials-both cells and the supporting scaffolding materials in which cells would be embedded and allowed to mature to eventually regenerate the organ in question. While some groups are focusing on the feasibility of this approach, few are focusing on the immunogenicity of the scaffolds that are being developed for organ bioengineering purposes...
September 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28892296/tailored-approaches-in-drug-development-and-diagnostics-from-molecular-design-to-biological-model-systems
#14
REVIEW
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M H Salo-Ahen, Ronald Österbacka, John E Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches...
September 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28891728/bioengineered-dermal-substitutes-for-the-management-of-traumatic-periocular-tissue-loss
#15
Tiffany A Chen, Juan A Ayala-Haedo, Nathan W Blessing, Katie Topping, Chrisfouad R Alabiad, Benjamin P Erickson
PURPOSE: Traumatic periocular injuries occasionally result in significant soft tissue loss, for which there are limited management options that provide satisfactory cosmetic and functional outcomes. The authors describe the use of a bioengineered dermal substitute (Integra® Dermal Regeneration Template [DRT], Integra LifeSciences, Plainsboro, NJ) as an alternative to immediate flap reconstruction or skin grafting. METHODS: Retrospective interventional case series of patients who underwent DRT placement for periocular tissue loss at the time of trauma...
September 11, 2017: Orbit
https://www.readbyqxmd.com/read/28889383/in-vitro-differentiation-and-propagation-of-urothelium-from-pluripotent-stem-cell-lines
#16
Stephanie L Osborn, Eric A Kurzrock
Bioengineering of bladder tissue, particularly for those patients who have advanced bladder disease, requires a source of urothelium that is healthy, capable of significant proliferation in vitro and immunologically tolerated upon transplant. As pluripotent stem cells have the potential to fulfill such criteria, they provide a critical cell source from which urothelium might be derived in vitro and used clinically. Herein, we describe the in vitro differentiation of urothelium from the H9 human embryonic stem cell (hESC) line through the definitive endoderm (DE) phase via selective culture techniques...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28888544/xylanase-immobilization-on-modified-superparamagnetic-graphene-oxide-nanocomposite-effect-of-pegylation-on-activity-and-stability
#17
Vajihe Mehnati-Najafabadi, Asghar Taheri-Kafrani, Abdol-Khalegh Bordbar
In order to utilize the advantages of immobilization such as improvement of stability, increasing the catalytic activity, ability to recovery and reuse of enzyme from reaction medium, xylanase enzyme was immobilized on superparamagnetic garphene oxide nanosheets (GOMNP). Xylanase, as a hydrolytic enzyme of xylan has widely used in industry. Since the xylan is bulk, for enhance accessibility of active sites of the immobilized xylanase, polyethylene glycol bis amine (PEGA) was used as a spacer for functionalization of GOMNP...
September 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28888164/retooling-microorganisms-for-the-fermentative-production-of-alcohols
#18
REVIEW
Helen S Toogood, Nigel S Scrutton
Bioengineering and synthetic biology approaches have revolutionised the field of biotechnology, enabling the introduction of non-native and de novo pathways for biofuels production. This 'retooling' of microorganisms is also applied to the utilisation of mixed carbon components derived from lignocellulosic biomass, a major technical barrier for the development of economically viable fermentations. This review will discuss recent advances in microorganism engineering for efficient production of alcohols from waste biomass...
September 6, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28887982/the-negative-effect-of-silica-nanoparticles-on-adipogenic-differentiation-of-human-mesenchymal-stem-cells
#19
Xing Yang, Xujie Liu, Yuanyuan Li, Qianli Huang, Wei He, Ranran Zhang, Qingling Feng, Dafna Benayahu
Nanoparticles have drawn much attention for a wide variety of applications in biomedical and bioengineering fields. The combined use of nanoparticles and human mesenchymal stem cells (hMSCs) in tissue engineering and regenerative medicine requires more knowledge of the influence of nanoparticles on cell viability and differentiation potential of hMSCs. The objective of this study is to investigate the in vitro uptake of silica nanoparticles (silica NPs) and their effect on adipogenic differentiation of hMSCs...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28883992/integrating-the-glioblastoma-microenvironment-into-engineered-experimental-models
#20
REVIEW
Weikun Xiao, Alireza Sohrabi, Stephanie K Seidlits
Glioblastoma (GBM) is the most lethal cancer originating in the brain. Its high mortality rate has been attributed to therapeutic resistance and rapid, diffuse invasion - both of which are strongly influenced by the unique microenvironment. Thus, there is a need to develop new models that mimic individual microenvironmental features and are able to provide clinically relevant data. Current understanding of the effects of the microenvironment on GBM progression, established experimental models of GBM and recent developments using bioengineered microenvironments as ex vivo experimental platforms that mimic the biochemical and physical properties of GBM tumors are discussed...
August 2017: Future Science OA
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