Rafael L Pereira, Bruna N Buscariollo, Matheus Corrêa-Costa, Patricia Semedo, Cassiano D Oliveira, Vanessa O Reis, Edgar Maquigussa, Ronaldo C Araújo, Tárcio T Braga, Maria F Soares, Ivan C Moura, Denise M A C Malheiros, Alvaro Pacheco-Silva Filho, Alexandre C Keller, Niels O S Câmara
Focal and segmental glomerulosclerosis (FSGS) is one of the most important causes of end-stage renal failure. The bradykinin B1 receptor has been associated with tissue inflammation and renal fibrosis. To test for a role of the bradykinin B1 receptor in podocyte injury, we pharmacologically modulated its activity at different time points in an adriamycin-induced mouse model of FSGS. Estimated albuminuria and urinary protein to creatinine ratios correlated with podocytopathy. Adriamycin injection led to loss of body weight, proteinuria, and upregulation of B1 receptor mRNA...
June 2011: Kidney International