Nikolett Lupsa, Barbara Érsek, Csenge Böröczky, Dávid Kis, Eszter Szarka, Katalin Lumniczky, Géza Sáfrány, Zoltán S Zádori, Árpád Szöőr, Edit I Buzás, Zoltán Pós
This study sought to compare the behavior of Treg subsets displaying different coexpression patterns of Neuropilin-1 (Nrp1) and Helios, under the influence of gut stress unrelated to hematopoietic stem cell transplantation, pretransplantation conditioning, and posttransplant gastrointestinal acute graft versus host disease (GI-aGvHD). Host CD4+ /CD25hi /Foxp3+ Treg cells, identified by flow cytometry, were isolated from various tissues of mice affected by these stressors. Expression of CD25, CTLA-4, CD39, OX40, integrin-β7, LAG3, TGFβ/LAP, granzyme-A, -B, and interleukin-10 was compared in four Treg subsets displaying Helios or Nrp1 only, both or none...
March 26, 2024: European Journal of Immunology