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https://www.readbyqxmd.com/read/29458002/the-effect-of-time-of-day-testing-and-utility-of-30-and-60-minute-cortisol-values-in-the-250-mcg-acth-stimulation-test
#1
Vicki Munro, Manal Elnenaei, Steve Doucette, David B Clarke, Syed Ali Imran
BACKGROUND: Despite widespread use of the 250-mcg Cosyntropin test (ACTH test) for the diagnosis of adrenal insufficiency (AI), the effect of time of day and the utility of performing both 30- and 60-min serum cortisol values remains unclear. METHODS: We conducted a retrospective cohort study of all ACTH testing at the Halifax Neuropituitary Program, Nova Scotia, Canada between January 2006 and April 2016. Data were collected on age, gender, medication history, serum cortisol levels at 0, 30 and 60 min after ACTH administration, as well as time of and indication for testing...
February 16, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29456299/atomic-force-microscopy-a-three-dimensional-reconstructive-tool-of-oral-microbiota-in-gingivitis-and-periodontitis
#2
Shyam Sunder Salavadhi, Srikanth Chintalapani, Radhika Ramachandran, Kirankumar Nagubandi, Arpita Ramisetti, Ramanarayana Boyapati
Aim: This study aims to ascertain the advantages of Atomic Force Microscopy (AFM) in the morphologic study of microorganisms and their interactions within the subgingival biofilm in patients with gingivitis and periodontitis. Settings and Design: Conducted a study on twenty patients, ten patients with severe periodontitis with probing the pocket depth of ≥8 mm, with a clinical attachment loss (CAL) of ≥6 mm CAL and ten patients with gingivitis: ≥5 mm pocket depth, and no attachment loss, was selected for the study...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29456254/far-ultraviolet-spectroscopy-of-old-novae-ii-rr-pic-v533-her-and-di-lac
#3
Edward M Sion, Patrick Godon, Liam Jones
The old novae V533 Her (Nova Her 1963), DI Lac (Nova Lac 1910), and RR Pic (Nova Pic 1891) are in (or near) their quiescent stage, following their nova explosions, and continue to accrete at a high rate in the aftermath of their explosions. They exhibit continua that are steeply rising into the FUV, as well as absorption lines and emission lines of uncertain origin. All three have Far Ultraviolet Spectroscopic Explorer ( FUSE ) spectra that offer not only higher spectral resolution but also wavelength coverage extending down to the Lyman Limit...
March 2017: Astronomical Journal
https://www.readbyqxmd.com/read/29455433/intracrine-action-of-angiotensin-ii-in-mesangial-cells-subcellular-distribution-of-angiotensin-ii-receptor-subtypes-at-1-and-at-2
#4
Antônio da Silva Novaes, Rosemara Silva Ribeiro, Luciana Guilhermino Pereira, Fernanda Teixeira Borges, Mirian Aparecida Boim
Biological effects of angiotensin II (AngII) such as regulation of AngII target genes may be triggered by interaction of AngII with intracellular AngII receptor types 1 and 2 (AT1 and AT2 ), defined as intracrine response. The aim of this study was to examine the presence of AT1 and AT2 receptors in nuclear membrane of human mesangial cells (HMCs) and evaluate the possible biological effects mediated by intracellular AT1 through an intracrine mechanism. Subcellular distribution of AT1 and AT2 was evaluated by immunofluorescence and by western blot in isolated nuclear extract...
February 17, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29453751/effects-of-ewe-s-milk-yogurt-whole-and-semi-skimmed-and-cow-s-milk-yogurt-on-inflammation-markers-and-gut-microbiota-of-subjects-with-borderline-high-plasma-cholesterol-levels-a-crossover-study
#5
Noemí Redondo, Natalia García-González, Ligia E Diaz-Prieto, Begoña Olmedilla-Alonso, Ana B Martín-Diana, Carmen Asensio-Vegas, Esther Nova
PURPOSE: Ewe's milk yogurt is richer in proteins, minerals and short- and medium-chain fatty acids compared to cow's milk yogurt. We aimed to evaluate the effects of cow's milk yogurt (CW, 3.0% fat), semi-skimmed (ES, 2.8% fat) and whole ewe's milk yogurts (EW, 5.8% fat) on inflammatory markers and gut microbiota in subjects with borderline-high plasma cholesterol. METHODOLOGY: 30 adults (16 women) were randomized into a crossover study to consume 250 g/yogurt/day during three 5-week periods (4-week washouts)...
February 16, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29451892/assessing-site-formation-and-assemblage-integrity-through-stone-tool-refitting-at-gruta-da-oliveira-almonda-karst-system-torres-novas-portugal-a-middle-paleolithic-case-study
#6
Marianne Deschamps, João Zilhão
We use stone tool refitting to assess palimpsest formation and stratigraphic integrity in the basal units of the Gruta da Oliveira archeo-stratigraphic sequence, layers 15-27, which TL and U-series dating places in late Marine Isotope Stage (MIS) 5 or early MIS 4. As in most karst contexts, the formation of this succession involved multiple and complex phenomena, including subsidence, bioturbation, carnivore activity and runoff as agents of potential post-depositional disturbance. During phases of stabilization, such as represented by layers 15, 21 and 22, the excavated area was inhabited and refits corroborate that post-depositional displacement is negligible...
2018: PloS One
https://www.readbyqxmd.com/read/29445114/kinesin-1-regulates-cilia-length-through-an-interaction-with-the-bardet-biedl-syndrome-related-protein-ccdc28b
#7
Rossina Novas, Magdalena Cardenas-Rodriguez, Paola Lepanto, Matías Fabregat, Magela Rodao, María Inés Fariello, Mauricio Ramos, Camila Davison, Gabriela Casanova, Lucía Alfaya, Federico Lecumberry, Gualberto González-Sapienza, Florencia Irigoín, Jose L Badano
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, polydactyly, renal disease and mental retardation. CCDC28B is a BBS-associated protein that we have previously shown plays a role in cilia length regulation whereby its depletion results in shortened cilia both in cells and Danio rerio (zebrafish). At least part of that role is achieved by its interaction with the mTORC2 component SIN1, but the mechanistic details of this interaction and/or additional functions that CCDC28B might play in the context of cilia remain poorly understood...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444771/consumption-of-ultra-processed-foods-and-cancer-risk-results-from-nutrinet-sant%C3%A3-prospective-cohort
#8
Thibault Fiolet, Bernard Srour, Laury Sellem, Emmanuelle Kesse-Guyot, Benjamin Allès, Caroline Méjean, Mélanie Deschasaux, Philippine Fassier, Paule Latino-Martel, Marie Beslay, Serge Hercberg, Céline Lavalette, Carlos A Monteiro, Chantal Julia, Mathilde Touvier
OBJECTIVE: To assess the prospective associations between consumption of ultra-processed food and risk of cancer. DESIGN: Population based cohort study. SETTING AND PARTICIPANTS: 104 980 participants aged at least 18 years (median age 42.8 years) from the French NutriNet-Santé cohort (2009-17). Dietary intakes were collected using repeated 24 hour dietary records, designed to register participants' usual consumption for 3300 different food items...
February 14, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29440344/nova-scotia-doctors-battle-government-over-pay-model
#9
Wendy Glauser
No abstract text is available yet for this article.
February 12, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29439784/influence-of-physical-activity-sedentary-behavior-and-diet-quality-in-childhood-on-the-incidence-of-internalizing-and-externalizing-disorders-during-adolescence-a-population-based-cohort-study
#10
XiuYun Wu, Kerry Bastian, Arto Ohinmaa, Paul Veugelers
PURPOSE: Studies among youth suggest that physical inactivity, sedentary behaviors, and poor diet quality are associated with poor mental health. Few population-based studies have investigated these relationships longitudinally. We examined the association between physical activity, sedentary behaviors, and diet quality in childhood and the incidence of internalizing and externalizing disorders throughout adolescence. METHODS: We linked health behavior survey data from 2003 among 10- to 11-year-old children across Nova Scotia, Canada, with administrative health care data from 2003 to 2011...
February 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29439660/the-impact-of-down-regulated-sk3-expressions-on-hirschsprung-disease
#11
Gunadi, Mukhamad Sunardi, Nova Yuli Prasetyo Budi, Alvin Santoso Kalim, Kristy Iskandar, Andi Dwihantoro
BACKGROUND: Some Hirschsprung's disease (HSCR) patients showed persistent bowel symptoms following an appropriately performed pull-through procedure. The mechanism is presumed to be down-regulated small-conductance calcium-activated potassium channel 3 (SK3) expression in the HSCR ganglionic intestines. We aimed to investigate the SK3 expression's impact in HSCR patients after a properly performed pull-through surgery in an Indonesian population, a genetically distinct group within Asia...
February 13, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29438687/increased-apob-apoa1-ratio-is-associated-with-excess-weight-body-adiposity-and-altered-lipid-profile-in-children
#12
Ana Paula Pereira Castro, Helen Hermana Miranda Hermsdorff, Luana Cupertino Milagres, Fernanda Martins Albuquerque, Mariana de Santis Filgueiras, Naruna Pereira Rocha, Juliana Farias de Novaes
OBJECTIVE: To investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factors in children. METHODS: Cross-sectional study with 258 children aged 8 and 9 years old, enrolled in all urban schools in the city of Viçosa-MG. An anthropometric evaluation of the body and biochemical composition of the children was performed. Socioeconomic variables and sedentary lifestyle were evaluated through a semi-structured questionnaire. RESULTS: Many children had excess weight (35...
February 10, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29437438/cosmic-ray-lithium-production-at-the-nova-eruptions-followed-by-a-type-ia-supernova
#13
Norita Kawanaka, Shohei Yanagita
Recent measurements of cosmic-ray (CR) light nuclei by AMS-02 have shown that there is an unexpected component of CR lithium whose spectral index is harder than that expected from the secondary production scenario. We propose the nearby type Ia supernova following a nova eruption as the origin of lithium nuclei in the CRs. By fitting the data of CR protons, helium, and lithium fluxes provided by AMS-02 with our theoretical model we show that this scenario is consistent with the observations. The observational tests that can check our hypothesis are briefly discussed...
January 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29433567/laryngeal-recurrence-sites-in-patients-previously-treated-with-transoral-laser-microsurgery-for-squamous-cell-carcinoma
#14
P Horwich, M H Rigby, C MacKay, J Melong, B Williams, M Bullock, R Hart, J Trites, S M Taylor
BACKGROUND: The laryngeal framework provides a natural barrier preventing tumour spread to extralaryngeal structures. Transoral laser microsurgery (TLM) for laryngeal squamous cell carcinoma (SCC) may violate these boundaries, altering the pathways of tumor spread for potential recurrences. Our project objective is to describe laryngeal SCC recurrence patterns and overall survival in patients requiring total laryngectomy (TL) after TLM. METHODS: Patients undergoing TLM for laryngeal SCC requiring salvage TL were identified from a prospective CO2 laser database containing all patients undergoing TLM for head and neck malignancies at the QEII Health Sciences Center in Halifax, Nova Scotia between March 2002 - May 2014...
February 13, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29430023/hubble-cos-spectroscopy-of-the-dwarf-nova-cw-mon-the-white-dwarf-in-quiescence
#15
Connor Hause, Edward M Sion, Patrick Godon, T Gänsicke Boris, Paula Szkody, Domitilla de Martino, Anna Pala
We present a synthetic spectral analysis of the HST COS spectrum of the U Geminorum-type dwarf nova CW Mon, taken during quiescence as part of our COS survey of accreting white dwarfs in Cataclysmic Variables. We use synthetic photosphere and optically thick accretion disk spectra to model the COS spectrum as well as archival IUE spectra obtained decades ago when the system was in an even deeper quiescent state. Assuming a reddening of E(B-V)=0.06, an inclination of 60° (CW Mon has eclipses of the accretion disk, and a white dwarf mass of 0...
August 2017: Astronomical Journal
https://www.readbyqxmd.com/read/29427591/steroid-regulation-an-overlooked-aspect-of-tolerance-and-chronic-rejection-in-kidney-transplantation
#16
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Sonia Norris, Yogesh Kamra, Rachel Hilton
Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared...
February 7, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29415698/nutritional-quality-of-new-food-products-released-into-the-australian-retail-food-market-in-2015-is-the-food-industry-part-of-the-solution
#17
Sheree A Spiteri, Dana Lee Olstad, Julie L Woods
BACKGROUND: Food manufacturers have made public statements and voluntary commitments, such as the Healthier Australia Commitment (HAC), to improve the nutritional quality of foods. However, limited information about the nutritional quality or healthfulness of new products makes it difficult to determine if manufacturers are doing this. The purpose of this study was to assess the healthfulness of new food products released into the Australian retail market in 2015, and whether those companies who were HAC members released healthier food options compared to non-HAC members...
February 7, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29414021/development-and-validation-of-a-high-performance-liquid-chromatography-method-for-the-quantitation-of-intracellular-parp-inhibitor-olaparib-in-cancer-cells
#18
Pierre Daumar, Robin Dufour, Clémence Dubois, Frédérique Penault-Llorca, Mahchid Bamdad, Emmanuelle Mounetou
Olaparib is a potent PARP inhibitor in clinical use for cancer therapy. A bioanalytical assay was developed and validated for quantitation of intracellular level of olaparib in cells exposed to the drug. The assay involves an optimized and straightforward sample pretreatment with acetonitrile for olaparib solubilization, cell lysis and protein precipitation, and a high performance liquid chromatography (HPLC) method with ultraviolet detection. Several parameters in both the sample preparation and the detection steps were investigated...
January 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29413493/supplementation-of-suckling-rats-with-cow-s-milk-induces-hyperphagia-and-higher-visceral-adiposity-in-females-at-adulthood-but-not-in-males
#19
Vanessa Silva Tavares Rodrigues, Egberto Gaspar Moura, Dayse Nascimento Bernardino, Janaine Cavalcanti Carvalho, Patricia Novaes Soares, Thamara Cherem Peixoto, Nayara Peixoto-Silva, Elaine Oliveira, Patricia Cristina Lisboa
In humans, complementary feeding should be started after 6 months-old; the introduction of any food or water before this time is considered early weaning, which is associated with health problems in adulthood. Cow's milk is a common food introduced to children less than 6 months that has inadequate nutritional composition mainly due to a worse casein: whey protein ratio compared to human milk. We hypothesized that suckling rats fed with cow's milk, rich in bioactive peptides, develop further metabolic dysfunctions...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29412388/effect-of-biliopancreatic-diversion-on-sleep-quality-and-daytime-sleepiness-in-patients-with-obesity-and-type-2-diabetes
#20
Mayra Mello, Ana Carolina J Vasques, José C Pareja, Maria da S de Oliveira, Fernanda S Novaes, Élinton A Chaim, Bruno Geloneze
OBJECTIVE: The poor quality of sleep and the deprivation thereof have been associated with disruption of metabolic homeostasis, favoring the development of obesity and type 2 diabetes (T2DM). We aimed to evaluate the influence of biliopancreatic diversion (BPD) surgery on sleep quality and excessive daytime sleepiness of obese patients with T2DM, comparing them with two control groups consisting of obese and normal weight individuals, both normal glucose tolerant. SUBJECTS AND METHODS: Forty-two women were divided into three groups: LeanControl (n = 11), ObeseControl (n = 13), and ObeseT2DM (n = 18)...
December 2017: Archives of Endocrinology and Metabolism
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