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B Christian Schmidt
Through integrating molecular, morphological and natural history evidence, nominal Hemaris diffinis (Boisduval) of eastern North America is shown to include a second, cryptic species, Hemaris aethra (Strecker) stat. rev. Despite highly divergent mtDNA sequences and differing larval phenotypes, genitalic morphology, habitat and larval host plants, adults of H. aethra and sympatric H. diffinis are externally so similar that H. aethra has remained unrecognized for over a century. With a more northerly distribution than H...
March 20, 2018: Zootaxa
VinÍcius C ClÁudio, Gedimar P Barbosa, Roberto Leonan M Novaes, FabrÍcio B Rassy, Vlamir J Rocha, Ricardo Moratelli
Lasiurus ebenus was known only from the holotype, which was collected in 1991, in an Atlantic Forest remnant of Ilha do Cardoso State Park, southeastern Brazil. The species was described based on qualitative and quantitative morphological features. Since its original description, based on a single individual, the taxonomic status of Lasiurus ebenus has been questioned. Here we report a second record for the species that comes from Carlos Botelho State Park, São Paulo, ca. 100 km north from the type locality...
April 5, 2018: Zootaxa
Roberto Leonan M Novaes, Guilherme S T Garbino, VinÍcius C ClÁudio, Ricardo Moratelli
Baird et al. (2015) split Lasiurus into three distinct genera (Aeorestes, Dasypterus and Lasiurus) based on tree topology and divergence times for the tribe Lasiurini. This arrangement has not been widely adopted by the scientific community and was criticized by Ziegler et al. (2016). More recently, Baird et al. (2017) reinforced the taxonomic arrangement of Lasiurini comprised by three genera. Baird et al. (2015, 2017) provided the most comprehensive phylogenetic analyses of Lasiurus and offer important insights on the phylogeny and alpha-taxonomy of the group...
February 15, 2018: Zootaxa
Lucas Henrique de Almeida, MaÍsa de Carvalho GonÇalves, Marcos Carneiro Novaes, Rayner Constantino Paresqui, PitÁgoras da conceiÇÃo Bispo
Specimens of the perlid stonefly Anacroneuria flintorum from different regions of the Brazilian Atlantic Forest along the Atlantic coast of Brazil were studied. In this paper, the nymph of A. flintorum is described based on reared specimens and molecular associations. Additionally, we provide new locality records and comments about variation of the species.
January 12, 2018: Zootaxa
Blanca Figuerola, Dennis P Gordon, Javier Cristobo
The present paper reports on 22 bryozoan species collected from 25 localities on the Southwestern Atlantic continental shelf and slope by the Instituto Español de Oceanografía vessel RV Miguel Oliver (2008-2010). Two new genera, Amynaskolia n. gen. and Biconcavus n. gen., and twenty new cheilostome species are described: Amastigia zigzag n. sp., Membranicellaria balanyai n. sp., Figularia dimorpha n. sp., Biconcavus batmani n. sp., Smittina acicularis n. sp., Smittoidea granulosa n. sp., Amynaskolia foramina n...
January 24, 2018: Zootaxa
Cory S Sheffield, Jennifer Heron
Background: Epeoloides pilosulus , one of the rarest bees in North America, is a cleptoparasite of Macropis bees which themselves are uncommon oligoleges of oil-producing Lysimachia flowers. Only two specimens of the cleptoparasite have been reported from Canada since the 1960s, both from Nova Scotia. New information: A recently collected specimen of Epeoloides pilosulus from Alberta, Canada confirms this species from that province and greatly increases its known range in western North America...
2018: Biodiversity Data Journal
H Mehta, J Weng, A Prater, R A L Elworth, X Han, Y Shamoo
Nocardia spp. are Gram positive opportunistic pathogens that affect largely immunocompromised patients leading to serious pulmonary or systemic infections. Combination therapy using the folate biosynthesis pathway inhibitors, trimethoprim and sulfamethoxazole (TMP-SMX) is commonly used as an antimicrobial therapy. Not surprisingly, as antibiotic therapies for nocardiosis can extend for many months, resistance to TMP-SMX has emerged. Using experimental evolution, we surveyed the genetic basis of adaptation to TMP-SMX across 8 strains of Nocardia nova and 2 strains of Nocardia cyriacigeorgica Employing both continuous experimental evolution to provide longitudinal information on the order of changes and characterization of resistant end-point isolates, we observe changes that are consistent with modification of two enzymes of the folate biosynthesis pathway: dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS/FolP) with the mutations often clustered near the active site of the enzymes...
April 23, 2018: Antimicrobial Agents and Chemotherapy
Estefanny Ruiz García, Eliana Alviárez Gutierrez, Fabiana Cristina Silveira Alves de Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process. Studies were selected from PubMed and Scopus databases according to the PRISMA statement. The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model. The bias analysis of the 34 selected works was done using the ARRIVE guidelines...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
John Papastergiou, Chantal Rene Trieu, Deborah Saltmarche, Artemis Diamantouros
OBJECTIVE: Streptococcus pyogenes is an aerobic, gram-positive bacterium responsible for a wide variety of infections including common pharyngitis. Novel rapid antigen detection tests allow for diagnosis of group A Streptococcus (GAS) at the point of care. The objective of the study is to evaluate the effects and feasibility of community pharmacist-directed GAS testing. SETTING: A retrospective analysis of aggregate billing data was conducted using descriptive statistics to evaluate the acceptance and feasibility of a community pharmacist-directed Streptococcus testing program at Shoppers Drug Mart pharmacies in the Canadian provinces of British Columbia, Alberta, and Nova Scotia...
April 19, 2018: Journal of the American Pharmacists Association: JAPhA
Robson Ventura de Souza, Carlos José Alexandre de Campos, Luis Hamilton Pospissil Garbossa, Luiz Fernando de Novaes Vianna, Walter Quadros Seiffert
This article describes a methodology for optimising predictive models for concentrations of faecal indicator organisms (FIOs) in coastal areas based on geographic and meteorological characteristics of upstream catchments. Concentrations of FIOs in mussels and water sampled from 50 sites in the south of Brazil from 2012 to 2013 were used to develop models to separately predict the spatial and temporal variations of FIOs. The geographical parameters used in predictive models for the spatial variation of FIOs were human population, urban area, percentage of impervious cover and total catchment area...
April 2018: Marine Pollution Bulletin
Fábio Junior Moreira Novaes, Ivaldo Itabaiana Junior, Felipe Korbus Sutili, Philip John Marriott, Humberto Ribeiro Bizzo, Francisco Radler de Aquino Neto, Rodrigo Octávio Mendonça Alves de Souza, Claudia Moraes Rezende
Cafestol and kahweol (C&K), two coffee diterpene alcohols with structural similarity which exhibit anticarcinogenic effects, were isolated from green coffee Arabica beans, followed by their lipase-catalysed esterification and purification by preparative high-performance liquid chromatography (HPLC). The isolation and enzymatic synthesis parameters of C&K esters were studied, with the latter optimised by a Central Composite Design; both procedures were monitored by gas chromatography. Scale up and improved isolation conditions resulted in 1...
September 1, 2018: Food Chemistry
Ananília Medeiros Gomes da Silva, Jéssica Nayara Góes de Araújo, Katiene Macêdo de Oliveira, Ana Eloísa Melo Novaes, Mariana Borges Lopes, Júlio César Vieira de Sousa, Antônio Amorim de Araújo Filho, André Ducati Luchessi, Adriana Augusto de Rezende, Mário Hiroyuki Hirata, Vivian Nogueira Silbiger
BACKGROUND: MicroRNAs (miRNAs) are involved in the pathogenesis of atrial fibrillation (AF), acting on development and progression. Our pilot study investigated the expression of six miRNAs and their miRNA-mRNA interactions in patients with acute new-onset AF, well-controlled AF, and normal sinus rhythm (controls). METHODS AND RESULTS: Plasma of acute new-onset AF patients (n = 5) was collected in the emergency room when patients presented with irregular and fast-atrial fibrillation rhythm...
April 20, 2018: Journal of Cardiovascular Electrophysiology
Anderson Petrauskas, Karina Andrea Novaes Olivieri, Yasmine Mendes Pupo, Guilherme Berger, Ederson Áureo Gonçalves Betiol
Aim: This study aims to evaluate the microshear bond strength of zirconia-based ceramics with different resin cement systems and surface treatments. Materials and Methods: Forty blocks of zirconia-based ceramic were prepared and embedded in polyvinyl chloride (PVC) tubes with acrylic resin. After polishing, the samples were washed in an ultrasonic bath and dried in an oven for 10 min. Half of the samples were subjected to sandblasting with aluminum oxide. Blocks were divided into four groups ( n = 10) in which two resin cements were used as follows: (1) RelyX™ U100 with surface-polished zirconia; (2) RelyX™ U100 with surface-blasted zirconia; (3) Multilink with surface-polished zirconia; and 4) Multilink with surface-blasted zirconia...
March 2018: Journal of Conservative Dentistry: JCD
Beverly Snaith, Martine A Harris, Bethany Shinkins, Marieke Jordaan, Michael Messenger, Andrew Lewington
BACKGROUND: Acute kidney injury (AKI) can occur rarely in patients exposed to iodinated contrast and result in contrast-induced AKI (CI-AKI). A key risk factor is the presence of preexisting chronic kidney disease (CKD); therefore, it is important to assess patient risk and obtain kidney function measurement prior to administration. Point-of-care (PoC) testing provides an alternative strategy but there remains uncertainty, with respect to diagnostic accuracy and clinical utility. METHODS: A device study compared three PoC analysers (Nova StatSensor, Abbott i-STAT and Radiometer ABL800 FLEX) with a reference laboratory standard (Roche Cobas 8000 series, enzymatic creatinine)...
April 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Marta Olivares, Alfonso Benítez-Páez, Giada de Palma, Amalia Capilla, Esther Nova, Gemma Castillejo, Vicente Varea, Ascensión Marcos, José Antonio Garrote, Isabel Polanco, Ester Donat, Carmen Ribes-Koninckx, Carmen Calvo, Luis Ortigosa, Francesc Palau, Yolanda Sanz
Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a role in the pathological process leading to gluten intolerance. In this study, we investigated the prevalence of pathogens in the intestinal microbiota of infants at familial risk of developing CD. We included 127 full-term newborns with at least one first-degree relative with CD. Infants were classified according to milk-feeding practice (breastfeeding or formula feeding) and HLA-DQ genotype (low, intermediate or high genetic risk)...
April 19, 2018: Gut Microbes
John Bartolacci, Judah Goldstein, Bryce Kiberd, Janel Swain, Amanda Vinson, David Clark, Karthik K Tennankore
BACKGROUND: Patients receiving chronic dialysis often require emergent and inpatient care; however, only a minimal amount is known about their out-of-hospital/inter-hospital use of Emergency Medical Services (EMS). The purpose of this study was to describe the utilization of EMS in a cohort of dialysis patients. METHODS: We analyzed a cohort of adult (≥18 years) chronic dialysis patients within the Nova Scotia Health Authority Central Zone Renal Program who initiated chronic dialysis between January 1, 2009 and June 30, 2013 (last follow up July 1, 2015)...
April 19, 2018: Prehospital Emergency Care
Nathalia Silva Araújo, Claudio José Dos Santos Júnior, Vitória Mikaelly da Silva Gomes, Luiz Arthur Calheiros Leite, Luana Novaes Bomfim, Amanda Katielly Firmino da Silva Gusmão, Maria Jordana Rocha Gomes Alves, Cyndi Myrelle da Silva Barros Romão, Arthur Moacir Costa Sampaio Batinga, Maria Rosa da Silva, Célio Fernando de Sousa Rodrigues
BACKGROUND Acute promyelocytic leukemia (APL) is a very rare leukemia in children. Extramedullary involvement by APL has been reported in between 3-5% of cases, mainly associated with cases of relapse. A rare case of relapse of APL in a 9-year-old child is presented with skin involvement with myeloid sarcoma. CASE REPORT A 9-year-old male child was admitted to the Oncology Service of the hospital complaining of fever, progressive fatigue, oral petechiae with severe bleeding in the oral cavity. Bone marrow examination showed some promyelocytes...
April 13, 2018: American Journal of Case Reports
Gwynn Ison, Lynn J Howie, Laleh Amiri-Kordestani, Lijun Zhang, Shenghui Tang, Rajeshwari Sridhara, Vadryn Pierre, Rosane Charlab, Anuradha Ramamoorthy, Pengfei Song, Fang Li, Jingyu Yu, Wimolnut Manheng, Todd R Palmby, Soma Ghosh, Hisani N Horne, Eunice Y Lee, Reena Philip, Kaushalkumar Dave, Xiao Hong Chen, Sharon L Kelly, Kumar G Janoria, Anamitro Banerjee, Okponanabofa Eradiri, Jeannette Dinin, Kirsten B Goldberg, William F Pierce, Amna Ibrahim, Paul G Kluetz, Gideon M Blumenthal, Julia A Beaver, Richard Pazdur
The Food and Drug Administration approved niraparib, a poly ADP ribose polymerase (PARP) inhibitor, on March 27, 2017, for maintenance treatment of patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response to platinum-based chemotherapy. Approval was based on data from the NOVA trial comparing niraparib with placebo in two independent cohorts, based on germline BRCA mutation status (gBRCAm vs. non-gBRCAm). Progression-free survival (PFS) in each cohort was the primary endpoint...
April 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Mariáurea Matias Sarandy, Lyvia Lopes Miranda, Luciana Schulthais Altoé, Rômulo Dias Novaes, Virgínia Vinha Zanuncio, João Paulo Viana Leite, Reggiani Vilela Gonçalves
Natural substances are used in folk medicines to treat injuries. Strychnos pseudoquina has scarring, antipyretic, and antimalarial actions. The present study aimed to analyze the effect of S. pseudoquina on cutaneous wound healing in rats. The S. pseudoquina extract was submitted to phytochemical prospection. The levels of flavonoids and total phenolic compounds in the extract were 50.7 mg/g and 2.59 mg/g, respectively. Thirty Wistar rats were individualized in cages with food and water ad libitum (registration no...
2018: PloS One
Luiz Fernando Toneto Novaes, Kaliandra de Almeida Gonçalves, Daniela B B Trivella, Julio Cezar Pastre
This full account describes our efforts towards the total synthesis of actinoranone. Our synthetic strategies rely on a convergent route to connect the terpenoid and polyketide fragments, employing catalysis and powerful classical reactions for the assembly of these key fragments. A new transformation was disclosed during this work, a domino ring-opening and esterification. Initial cytotoxic studies for selected synthetic intermediates are also presented.
April 12, 2018: Journal of Organic Chemistry
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