keyword
MENU ▼
Read by QxMD icon Read
search

pancreatitis and metabolic disorders

keyword
https://www.readbyqxmd.com/read/29792143/recent-updates-on-novel-approaches-in-insulin-drug-delivery-a-review-of-challenges-and-pharmaceutical-implications
#1
Manisha Pandey, Hira Choudhury, Cheah Xiao Yi, Chen Wei Mun, Goh Khang Ping, Guee Xin Rou, Bhalqish Jeet Kaur A/P Ambar Jeet Singh, Angel Ng Ann Jhee, Lee Kai Chin, Prashant Kesharwani, Bapi Gorain, Zahid Hussain
Diabetes mellitus, a metabolic disorder of glucose metabolism, is mainly associated with insulin resistance to the body cells, or impaired production of insulin by the pancreatic β-cells. Insulin is mainly required to regulate glucose metabolism in type 1 diabetes mellitus patients; however, many patients with type 2 diabetes mellitus also require insulin, especially when their condition cannot be controlled solely by oral hypoglycemic agents. Hence, major researches are ongoing attempting to improve the delivery of insulin in order to make it more convenient to patients who experience side effects from the conventional treatment procedure or non-adherence to insulin regimen due to multiple comorbid conditions...
May 22, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29749475/mir-125a-induces-apoptosis-metabolism-disorder-and-migrationimpairment-in-pancreatic-cancer-cells-by-targeting-mfn2-related-mitochondrial-fission
#2
Lichao Pan, Lin Zhou, Weijia Yin, Jia Bai, Rong Liu
Mitochondrial fission is important for the development and progression of pancreatic cancer (PC). However, little is known regarding its role in pancreatic cancer apoptosis, metabolism and migration. In the current study, the mechanism by which mitochondrial fission modifies the biological characteristics of PC was explored. MicroRNA‑125a (miR‑125a) had the ability to inhibit mitochondrial fission and contributed to cellular survival. Suppressed mitochondrial fission led to a reduction in mitochondrial debris, preserved the mitochondrial membrane potential, inhibited mitochondrial permeability transition pore opening, ablated cytochrome c leakage into the cytoplasm and reduced the pro‑apoptotic protein contents, finally blocking mitochondria related apoptosis pathways...
April 26, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29747741/evaluation-of-anti-lipase-activity-and-bioactive-flavonoids-in-the-citri-reticulatae-pericarpium-from-different-harvest-time
#3
Su-Ling Zeng, Shang-Zhen Li, Chang-Jiang-Sheng Lai, Min-Yan Wei, Bai-Zhong Chen, Ping Li, Guo-Dong Zheng, E-Hu Liu
BACKGROUND: Inhibition of pancreatic lipase is an attractive approach to the treatment of obesity and other metabolic disorders. Naturally occurring phytochemicals are promising sources of lipase inhibitors. PURPOSE: In the present study, the anti-lipase activity of Citri Reticulatae Pericarpium (CRP) extracts was firstly evaluated in vitro. Moreover, the dynamic alteration of bioactive flavonoids in CRP collected at different time and its correlation with anti-lipase activities was investigated...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746922/diabetes-and-pancreatic-neuroendocrine-tumours-which-interplays-if-any
#4
REVIEW
Marco Gallo, Rosaria Maddalena Ruggeri, Giovanna Muscogiuri, Genoveffa Pizza, Antongiulio Faggiano, Annamaria Colao
Pancreatic neuroendocrine tumours (PanNETs) represent an uncommon type of pancreatic neoplasm, whose incidence is increasing worldwide. As per exocrine pancreatic cancer, a relationship seems to exist between PanNETs and glycaemic alterations. Diabetes mellitus (DM) or impaired glucose tolerance often occurs in PanNET patients as a consequence of hormonal hypersecretion by the tumour, specifically affecting glucose metabolism, or due to tumour mass effects. On the other hand, pre-existing DM may represent a risk factor for developing PanNETs and is likely to worsen the prognosis of such patients...
May 2, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29745909/a-young-adult-with-generalized-lipodystrophy-and-diabetes-mellitus-case-report
#5
E Çelo, B Kalari, F Toti
Lipodystrophies are a group of heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. Lipodystrophy associated metabolic abnormalities include insulin resistance, that often lead to diabetes mellitus and its complications, hypertriglyceridemia that may be severe enough to cause acute pancreatitis, and hepatic steatosis that may lead to cirrhosis. We present the case of an 18-year-old female who was hospitalized as an inaugural Diabetes Mellitus...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29729169/optimization-of-the-complex-therapy-of-chronic-pancreatitis-with-metabolic-syndrome
#6
Liliya S Babinets, Nataliia A Melnyk, Nataliia O Shevchenko, Galina M Sasyk, Olexandr S Zemlyak, Olexandra Ye Kopach, Olga Ye Fedoriv
OBJECTIVE: Inroduction: The most common reasons of chronic pancreatitis are alcohol abuse, biliary tract and liver diseases, stomach and duodenum, hyperlipidemia, which is often associated with metabolic syndrome. The aim: to study the effectiveness of using medicine omega-3 polyunsaturated fatty acids in standard therapy to the correction of lipids and prooxidant-antioxidant disorders in patients with chronic pancreatitis and metabolic syndrome. PATIENTS AND METHODS: Materials and methods: The study included 90 patients with chronic pancreatitis with metabolic syndrome...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29723245/sarcopenia-and-myosteatosis-are-accompanied-by-distinct-biological-profiles-in-patients-with-pancreatic-and-periampullary-adenocarcinomas
#7
Cynthia Stretch, Jean-Michel Aubin, Beata Mickiewicz, Derek Leugner, Tariq Al-Manasra, Elizabeth Tobola, Santiago Salazar, Francis R Sutherland, Chad G Ball, Elijah Dixon, Hans J Vogel, Sambasivario Damaraju, Vickie E Baracos, Oliver F Bathe
INTRODUCTION: Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low muscle radiodensity due to fat infiltration in muscle (myosteatosis). The biological and clinical correlates to these features are poorly understood. METHODS: Clinical characteristics and outcomes were studied in 123 patients who underwent pancreaticoduodenectomy for pancreatic or non-pancreatic periampullary adenocarcinoma and who had available preoperative CT scans...
2018: PloS One
https://www.readbyqxmd.com/read/29686083/unexpected-metabolic-disorders-induced-by-endocrine-disruptors-in-xenopus-tropicalis-provide-new-lead-for-understanding-amphibian-decline
#8
Christophe Regnault, Marie Usal, Sylvie Veyrenc, Karine Couturier, Cécile Batandier, Anne-Laure Bulteau, David Lejon, Alexandre Sapin, Bruno Combourieu, Maud Chetiveaux, Cédric Le May, Thomas Lafond, Muriel Raveton, Stéphane Reynaud
Despite numerous studies suggesting that amphibians are highly sensitive to endocrine disruptors (EDs), both their role in the decline of populations and the underlying mechanisms remain unclear. This study showed that frogs exposed throughout their life cycle to ED concentrations low enough to be considered safe for drinking water, developed a prediabetes phenotype and, more commonly, a metabolic syndrome. Female Xenopus tropicalis exposed from tadpole stage to benzo( a )pyrene or triclosan at concentrations of 50 ng⋅L-1 displayed glucose intolerance syndrome, liver steatosis, liver mitochondrial dysfunction, liver transcriptomic signature, and pancreatic insulin hypersecretion, all typical of a prediabetes state...
April 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29684618/everolimus-is-a-new-anti-cancer-molecule-metabolic-side-effects-as-lipid-disorders-and-hyperglycemia
#9
REVIEW
L Morviducci, F Rota, L Rizza, P Di Giacinto, S Ramponi, M R Nardone, C Tubili, A Lenzi, P Zuppi, R Baldelli
In the last few years, molecular targeted therapies have replaced traditional cytotoxic chemotherapy in the fight against many cancers to the extent that our understanding of tumor biology has become more sophisticated. This shift has markedly changed adverse event profiles, compared to cytotoxic chemotherapy, affecting a diverse range of organ systems. Everolimus was approved by the FDA in 2011 for the treatment of progressive pancreatic NE tumors (Yao, 2011; Jensenn, 2012). It is an inhibitor of mammalian target of rapamycin (mTOR) and exhibits antitumor activity via disruption of various signaling pathways and it's used in the treatment of advanced renal cell cancer, breast cancer and neuroendocrine tumors (NET); it's used also as anti-rejection agent for transplantation but with lower doses for anti-rejection (1...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29681182/fetal-pancreatic-langerhans-islets-size-in-pregnancies-with-metabolic-disorders
#10
Laura Avagliano, Margaret Mascherpa, Valentina Massa, Patrizia Doi, Gaetano P Bulfamante
Metabolic disorders are a pandemic and increasing health problem. Women of childbearing age may also be affected, thus an abnormal metabolism may interfere with pregnancy short and long term outcomes, harming both mother and child. In the context of an abnormal maternal and intrauterine metabolic milieu the development of fetal organs, including pancreas, may be affected. The aim of the present study is to investigate the effects of pregnancy metabolic disorders on the morphology of pancreatic Langerhans islets in human late-third trimester stillborn fetuses...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29679542/treatments-for-diabetes-mellitus-type-ii-new-perspectives-regarding-the-possible-role-of-calcium-and-camp-interaction
#11
REVIEW
Diego Soares Carvalho, Alexandre Aparecido de Almeida, Aurélio Ferreira Borges, Vannucci Campos
Diabetes mellitus (DM) is among the top ten causes of death worldwide. It is considered to be one of the major global epidemics of the 21st century, with a significant impact on public health budgets. DM is a metabolic disorder with multiple etiologies. Its pathophysiology is marked by dysfunction of pancreatic β-cells which compromises the synthesis and secretion of insulin along with resistance to insulin action in peripheral tissues (muscle and adipose). Subjects presenting insulin resistance in DM type 2 often also exhibit increased insulin secretion and hyperinsulinemia...
April 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29609556/the-warburg-effect-in-human-pancreatic-cancer-cells-triggers-cachexia-in-athymic-mice-carrying-the-cancer-cells
#12
Feng Wang, Hongyi Liu, Lijuan Hu, Yunfei Liu, Yijie Duan, Rui Cui, Wencong Tian
BACKGROUND: Cancer cachexia is a cancer-induced metabolic disorder and a major cause of cancer-induced death. The constituents of cancer cachexia include an increase in energy expenditure, hepatic gluconeogenesis, fat lipolysis, and skeletal-muscle proteolysis and a decrease in body weight. The aetiology of cancer cachexia is unclear and may involve cancer-cell metabolism and secretion. In this study, we investigated whether the high glycolysis in cancer cells (the Warburg effect) triggers cachexia in athymic mice carrying pancreatic cancer cells...
April 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29599416/low-protein-diet-in-puberty-impairs-testosterone-output-and-energy-metabolism-in-male-rats
#13
Júlio Cezar de Oliveira, Egberto G Moura, Rosiane Aparecida Miranda, Ana Moraes, Luiz Felipe Barella, Ellen Paula Santos da Conceição, Rodrigo Mello Gomes, Tatiane Aparecida da Silva Ribeiro, Ananda Malta, Isabela Peixoto Martins, Claudinéia Conationi da Silva Franco, Patricia Lisboa, Paulo Cezar de Freitas Mathias
We examined the long-term effects of protein restriction during puberty on the function of hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes in male rats. Male Wistar rats were fed a low-protein diet (4%, LP) from 30 to 60 days-old. A normal-protein diet (20.5%) was reintroduced from 60 to 120 days-old. Control rats were fed a normal-protein diet throughout life (NP). Rats were euthanized at 60 or 120 days-old. Food consumption, body weight, visceral fat deposits, lipid profile, glycemia, insulinemia, corticosteronemia, adrenocorticotropic hormone (ACTH), testosteronemia and leptinemia were evaluated...
March 29, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29594720/ligand-binding-and-conformational-changes-of-sur1-subunit-in-pancreatic-atp-sensitive-potassium-channels
#14
Jing-Xiang Wu, Dian Ding, Mengmeng Wang, Yunlu Kang, Xin Zeng, Lei Chen
ATP-sensitive potassium channels (KATP ) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore important drug targets. Here, we present three structures of pancreatic KATP channels solved by cryo-electron microscopy (cryo-EM), at resolutions ranging from 4.1 to 4.5 Å. These structures depict the binding site of the antidiabetic drug glibenclamide, indicate how Kir6...
March 28, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29587416/knocking-down-insulin-receptor-in-pancreatic-beta-cell-lines-with-lentiviral-small-hairpin-rna-reduces-glucose-stimulated-insulin-secretion-via-decreasing-the-gene-expression-of-insulin-glut2-and-pdx1
#15
Jie Wang, Wenyi Gu, Chen Chen
Type 2 diabetes (T2D) is a metabolic disorder characterized by beta cell dysfunction and insulin resistance in fat, muscle and liver cells. Recent studies have shown that the development of insulin resistance in pancreatic beta cell lines may contribute to beta cell dysfunction in T2D. However, there still is a lack of detailed investigations regarding the mechanisms by which insulin deficiency may contribute in diabetes. In this study, we firstly established a stable insulin receptor knockdown cell line in pancreatic beta cells INS-1 (InsRβKD cells) using anti InsRβ small hairpin RNA (InsRβ-shRNA) encoded by lentiviral vectors...
March 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29580009/in-vitro-and-in-vivo-anti-diabetic-and-anti-hyperlipidemic-effects-of-protein-hydrolysates-from-octopus-vulgaris-in-alloxanic-rats
#16
Rabeb Ben Slama-Ben Salem, Naourez Ktari, Intidhar Bkhairia, Rim Nasri, Leticia Mora, Rim Kallel, Safa Hamdi, Kamel Jamoussi, Tahia Boudaouara, Abdelfettah El-Feki, Fidel Toldrá, Moncef Nasri
This study aims to examine the effects of non-hydrolyzed octopus (Octopus vulgaris) muscle proteins (NHOPs) and their hydrolysates (OPHs) on alloxan induced diabetes in Wistar rats (AIDR). Animals were allocated into seven groups of six rats each: control group (C), diabetic group (D) and diabetic rats treated with acarbose (D + Acar), non-hydrolyzed octopus proteins (D + NHOPs) and octopus proteins hydrolysates (D + OPHs) groups. The diabetic rats presented a significant increase in glycemic status such as α-amylase activity (in plasma, pancreas and intestine), hepatic glycogen, blood glucose and glycated hemoglobin (HbA1c) levels, as well as a significant decrease in the levels of plasma insulin and total hemoglobin compared to control group...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29578634/mtor-a-double-edged-sword-for-diabetes
#17
REVIEW
Yali Tuo, Ming Xiang
Diabetes is both a metabolic and an immune disorder. One intriguing link between the two is the serine-threonine protein kinase mammalian target of rapamycin (mTOR). As a component of the PI3K/Akt pathway and other cellular signals, mTOR is a key regulator of fuel metabolism and function of both pancreatic islet β cells and immune cells. Consequently, it seems that mTOR has both anti- and prodiabetic effects. On the one hand, activation of mTOR in β cells can increase their growth and proliferation, opposing impairments of insulin secretion in diabetes...
March 26, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29574296/novel-prodrug-prx-p4-003-selectively-activated-by-gut-enzymes-may-reduce-the-risk-of-iatrogenic-addiction-and-abuse
#18
Sandeep T Patil, Ron H Bihovsky, Steven A Smith, William Z Potter, Valentino J Stella
OBJECTIVES: Prescription stimulants are vulnerable to oral and parenteral abuse. Intravenous forms of abuse may be most detrimental due to an enhanced risk of dependence, overdose, and infectious diseases. Our objective was to discover an orally active prodrug of a stimulant that would not be easily converted to its parent when injected, thus hindering intravenous abuse. METHODS: Following an initial analysis of stimulant structures, the fencamfamine isomer [(-)-FCF; (N-ethyl-3-phenylbicyclo[2...
March 2, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29571020/experimental-diabetes-induced-by-streptozotocin-in-the-desert-gerbil-gerbillus-gerbillus-and-the-effects-of-short-term-20-hydroxyecdysone-administration
#19
Aicha Mallek, Jamileh Movassat, Souad Ameddah, Junjun Liu, Nesrine Semiane, Ali Khalkhal, Yasmina Dahmani
The present work was aimed at studying the effects of streptozotocin (STZ; 130 mg/kg) in the desert gerbil, Gerbillus gerbillus, and at evaluating the impact of the short-term administration of 20-hydroxyecdysone (20E; 5 mg/kg). We observed that administration of streptozotocin caused a significant increase in plasmatic glucose and a decrease in insulin levels. The plasma lipid profile and liver glycogen content were also altered. The activities of antioxidant enzymes and malondialdehyde (MDA) levels were increased in the pancreatic tissue of STZ-treated gerbils...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29534878/roundtable-discussion-familial-chylomicronemia-syndrome-diagnosis-and-management
#20
REVIEW
William Virgil Brown, Ira Goldberg, Barton Duell, Daniel Gaudet
Plasma triglyceride concentrations are normally below 150 mg/dL in the fasting state. However, these lipids can reach values of several thousand mg/dL. Elevations in this range are due to a massive retention of chylomicrons and usually result from multiple genetic variants with superimposed influences such as diabetes and immune disorders. Less commonly, major gene defects in lipoprotein metabolism can be the cause. These may present soon after birth with strong evidence of familial penetrance. The causes of this syndrome have been discussed in a Roundtable published in the most recent issue of this Journal...
March 2018: Journal of Clinical Lipidology
keyword
keyword
59445
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"