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Evidenced based medicine

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https://www.readbyqxmd.com/read/29788944/bronchiectasis-an-emerging-global-epidemic
#1
EDITORIAL
Sanjay H Chotirmall, James D Chalmers
Bronchiectasis has an increasing profile within respiratory medicine. This chronic and irreversible airways disease is common but suffers from a lack of evidenced based therapy for patients and, a lack of understanding of its inherent heterogeneity. Research focused on bronchiectasis must therefore be prioritized if we are to adequately address this evolving clinical problem. This special issue on bronchiectasis focuses on its clinical, microbiological and therapeutic aspects. By bringing together a unique collection of original research and review articles, we hope this issue will showcase international research efforts, encourage future research collaborations and stimulate debate...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29784011/extremely-low-frequency-electromagnetic-fields-promote-mesenchymal-stem-cell-migration-by-increasing-intracellular-ca-2-and-activating-the-fak-rho-gtpases-signaling-pathways-in-vitro
#2
Yingchi Zhang, Jiyuan Yan, Haoran Xu, Yong Yang, Wenkai Li, Hua Wu, Chaoxu Liu
BACKGROUND: The ability of mesenchymal stem cells (MSCs) to migrate to the desired tissues or lesions is crucial for stem cell-based regenerative medicine and tissue engineering. Optimal therapeutics for promoting MSC migration are expected to become an effective means for tissue regeneration. Electromagnetic fields (EMF), as a noninvasive therapy, can cause a lot of biological changes in MSCs. However, whether EMF can promote MSC migration has not yet been reported. METHODS: We evaluated the effects of EMF on cell migration in human bone marrow-derived MSCs...
May 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29751503/simulation-as-a-central-feature-of-an-elective-course-does-simulated-bedside-care-impact-learning
#3
Michael C Thomas, Peter J Hughes
A three-credit, simulation-based, emergency medicine elective course was designed and offered to doctor of pharmacy students for two years. The primary objective was to determine if there was a difference in exam performance stratified by student simulation experience, namely either as an active observer or as part of bedside clinical care. The secondary objective was to report student satisfaction. Examination performance for simulation-based questions was compared based on the student role (evaluator versus clinical) using the Student’s t -test...
May 3, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29710004/-paradigm-shift-in-the-quality-of-regional-medical-care-cooperative-treatment-of-onychomycosis
#4
Junko Suzuki, Yoshihiro Imazu, Yoshitaka Yoneta, Katsunori Yamaura, Emiko Uchida
 In a superaging society, the medical paradigm should include both less coverage of medical-care work flow by human resources and high-quality care for patients. Strategies such as establishing medical-care teams and community medicine systems mainly for home medical care should be implemented. However, a well-organized system for home-based medical treatment of elderly patients is not yet in place, as evidenced by the lack of care, problems with long-term polypharmacy resulting from visits to multiple healthcare providers, and declines in their physical strength...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29658045/potential-of-borojoa-patinoi-cuatrecasas-water-extract-to-inhibit-nosocomial-antibiotic-resistant-bacteria-and-cancer-cell-proliferation-in-vitro
#5
Clemencia Chaves-López, Donatella Usai, Matthew Gavino Donadu, Annalisa Serio, Robert Tulio González-Mina, Maria Chiara Simeoni, Paola Molicotti, Stefania Zanetti, Antonio Pinna, Antonello Paparella
Borojó (Borojoa patinoi Cuatrec.) is a fruit used in Colombian traditional medicine with supposed antihypertensive, antitumoral, diuretic, healing, immunological, anti-inflammatory and aphrodisiac effects. To explore the relative merits in terms of biological activities of borojó aqueous extract (BAE), we investigated in vitro its antimicrobial activity on nosocomial pathogenic and multidrug resistant (MDR) strains of Pseudomonas aeruginosa (6), Staphylococcus aureus (1) and Candida species (6), as well as its cytotoxicity on human conjunctive Wong-Kilbourne derivative (WKD) cells and Caco-2 cells from heterogeneous human epithelial colorectal adenocarcinoma...
April 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29648617/society-of-behavioral-medicine-sbm-position-statement-enact-taxes-on-sugar-sweetened-beverages-to-prevent-chronic-disease
#6
Daniel R Taber, Akilah Dulin-Keita, Megan Fallon, Frank J Chaloupka, Tatiana Andreyeva, Marlene B Schwartz, Jennifer L Harris
The Society of Behavioral Medicine (SBM) encourages stakeholders to implement a sugar sweetened beverage excise tax. Sugar sweetened beverages are the largest source of added sugars in the USA and have detrimental effects on population health by increasing risks for chronic diseases. Based on existing research evidence, SBM supports an excise tax equivalent to at least 20% to meaningfully affect consumption patterns. As evidenced by research studies in Mexico and the USA, sugar sweetened beverage taxes can have positive impacts on population health and can raise significant tax revenue...
April 10, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29643058/a-conceptual-framework-for-addressing-residual-atherosclerotic-cardiovascular-disease-risk-in-the-era-of-precision-medicine
#7
Kershaw V Patel, Ambarish Pandey, James A de Lemos
Until recently, therapies to mitigate atherosclerotic cardiovascular disease (ASCVD) risk have been limited to lifestyle interventions, blood pressure lowering medications, high intensity statin therapy, antiplatelet agents, and in select patients, coronary artery revascularization. Despite administration of these evidence-based therapies, substantial residual risk for cardiovascular events persists, particularly among individuals with known ASCVD. Moreover, the current guideline-based approach does not adequately account for patient-specific, causal pathways that lead to ASCVD progression and complications...
April 11, 2018: Circulation
https://www.readbyqxmd.com/read/29615047/potent-antiplasmodial-extracts-and-fractions-from-terminalia-mantaly-and-terminalia-superba
#8
Cedric D J Mbouna, Rufin M T Kouipou, Rodrigue Keumoe, Lauve R Y Tchokouaha, Patrick V T Fokou, Brice M T Tali, Dinkar Sahal, Fabrice F Boyom
BACKGROUND: The emergence and spread of malaria parasites resistant to artemisinin-based combination therapy stresses the need for novel drugs against malaria. Investigating plants used in traditional medicine to treat malaria remains a credible option for new anti-malarial drug development. This study was aimed at investigating the antiplasmodial activity and selectivity of extracts and fractions from Terminalia mantaly and Terminalia superba (Combretaceae) that are used in Cameroon to treat malaria...
April 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29571018/stem-cell-therapy-in-asherman-syndrome-and-thin-endometrium-stem-cell-based-therapy
#9
REVIEW
Ramyar Azizi, Leili Aghebati-Maleki, Mohammad Nouri, Faroogh Marofi, Sohrab Negargar, Mehdi Yousefi
The endometrium is one of the essential components of the uterus. The endometrium of human is a complex and dynamic tissue, which undergoes periods of growth and turn over during any menstrual cycle. Stem cells are initially undifferentiated cells that display a wide range of differentiation potential with no distinct morphological features. Stem cell therapy method recently has become a novel procedure for treatment of tissue injury and fibrosis in response to damage. Currently, there is massive interest in stem cells as a novel treatment method for regenerative medicine and more specifically for the regeneration of human endometrium disorder like Asherman syndrome (AS) and thin endometrium...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568453/a-thiocyanopalladation-carbocyclization-transformation-identified-through-enzymatic-screening-stereocontrolled-tandem-c-scn-and-c-c-bond-formation
#10
G Malik, R A Swyka, V K Tiwari, X Fei, G A Applegate, D B Berkowitz
Herein we describe a formal thiocyanopalladation/carbocyclization transformation and its parametrization and optimization using a new elevated temperature plate-based version of our visual colorimetric enzymatic screening method for reaction discovery. The carbocyclization step leads to C-SCN bond formation in tandem with C-C bond construction and is highly stereoselective, showing nearly absolute 1,2- anti -stereoinduction (5 examples) for substrates bearing allylic substitution, and nearly absolute 1,3- syn -stereoinduction (16 examples) for substrates bearing propargylic substitution...
December 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29534962/barbaloin-loaded-polydopamine-polylactide-tpgs-pla-tpgs-nanoparticles-against-gastric-cancer-as-a-targeted-drug-delivery-system-studies-in-vitro-and-in-vivo
#11
Yi-Ran Wang, Shi-Yan Yang, Guang-Xia Chen, Ping Wei
Gastric cancer is the third leading cause of cancer-associated death worldwide. Although a decrease in its incidence is observed, gastric cancer still poses a major clinical challenge due to poor prognosis and limited treatments. Barbaloin (BBL) is a main medicinal composition of the Chinese traditional medicine aloe vera. BBL has various bioactivities, including anti-oxidant, anti-inflammatory and anti-tumor properties. Polydopamine (pD)-based surface modification is easy to functionalize polymeric nanoparticles (NPs) surfaces with ligands and/or additional polymeric layers...
April 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29531882/creating-a-student-centered-learning-environment-implementation-of-problem-based-learning-to-teach-microbiology-to-undergraduate-medical-students
#12
Venkataramana Kandi, Parimala Reddy Basireddy
Introduction Medical education involves training necessary to become a physician or a surgeon. This includes various levels of training like undergraduate, internship, and postgraduate training. Medical education can be quite complex, since it involves training in pre-clinical subjects (anatomy, physiology, biochemistry), the para-clinical subjects (microbiology, pathology, pharmacology, and forensic medicine), and a discrete group of clinical subjects that include general medicine, surgery, obstetrics and gynaecology, ear, nose and throat specialization, paediatrics, cardiology, pulmonology, dermatology, ophthalmology, and orthopaedics, and many other clinical specializations and super specialities (cardio-thoracic surgery, neurosurgery, etc...
January 5, 2018: Curēus
https://www.readbyqxmd.com/read/29530081/evaluating-optimal-utilisation-of-technology-in-type-1-diabetes-mellitus-from-a-clinical-and-health-economic-perspective-protocol-for-a-systematic-review
#13
Anthony Pease, Clement Lo, Arul Earnest, Danny Liew, Sophia Zoungas
BACKGROUND: Technology has been implemented since the 1970s with the hope of improving glycaemic control and reducing the burden of complications for those living with type 1 diabetes. A clinical and cost-effectiveness comparison of all available technologies including continuous subcutaneous insulin infusion (CSII), continuous glucose monitors (CGMs), sensor-augmented pump therapy (including either low-glucose suspend or predictive low-glucose suspend), hybrid closed-loop systems, closed-loop (single-hormone or dual-hormone) systems, flash glucose monitoring (FGM), insulin bolus calculators, and 'smart-device' applications is currently lacking...
March 12, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29468964/recent-advances-in-antibacterial-antiprotozoal-and-antifungal-trends-of-eurycoma-longifolia-a-review-of-therapeutic-implications-and-future-prospects
#14
Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia (E. longifolia) has gained widespread recognition due to its versatile pharmacological activities including aphrodisiac, anticancer, antimicrobial, antioxidant, anti-inflammatory, anxiolytic, anti-diabetic, ergogenic, insecticidal, anti-rheumatism, bone protection, and anti-ulcer effects. OBJECTIVE: This review was aimed to critically overview the literature and summarizes the antibacterial, antiprotozoal, and antifungal trends of E...
February 19, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29466787/a-strategy-for-optimizing-the-combination-of-active-components-based-on-chinese-medicinal-formula-sheng-mai-san-for-myocardial-ischemia
#15
Fang Li, Xiao-Xue Fan, Chun Chu, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu
BACKGROUND/AIMS: Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years and has accumulated considerable knowledge concerning the in vivo efficacy of targeting complicated diseases. TCM formulae are a mixture of hundreds of chemical components with multiple potential targets, essentially acting as a combination therapy of multi-component drugs. However, the obscure substances and the unclear molecular mechanisms are obstacles to their further development and internationalization...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29374886/-some-reflections-on-evidenced-based-medicine-precision-medicine-and-big-data-based-research
#16
J L Tang, L M Li
Evidence-based medicine remains the best paradigm for medical practice. However, evidence alone is not decisions; decisions must also consider resources available and the values of people. Evidence shows that most of those treated with blood pressure-lowering, cholesterol-lowering, glucose-lowering and anti-cancer drugs do not benefit from preventing severe complications such as cardiovascular events and deaths. This implies that diagnosis and treatment in modern medicine in many circumstances is imprecise...
January 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29315426/an-e-learning-module-on-chronic-low-back-pain-in-older-adults-effect-on-medical-resident-attitudes-confidence-knowledge-and-clinical-skills
#17
Zachary G Jacobs, D Michael Elnicki, Subashan Perera, Debra K Weiner
Objective: To determine 1) the feasibility of implementing an e-learning module on chronic low back pain (CLBP) in an older adult into an existing internal medicine residency curriculum and 2) the impact of this module on resident attitudes, confidence, knowledge, and clinical skills relating to CLBP. Methods: Participants were assigned to complete either the online module (N = 73) or the Yale Office-based curriculum on CLBP (N = 70). Attitudes, confidence, and knowledge were evaluated pre- and postintervention via survey...
January 5, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29288521/indigenous-cultural-competence-a-dental-faculty-curriculum-review
#18
C Forsyth, M Irving, M Tennant, S Short, J Gilroy
BACKGROUND: Indigenous Australians have more than double the rate of poor oral health than their non-Indigenous counterparts. Cultural competence of dental and oral health practitioners is fundamental to health care and quality of life in addressing health disparities in minority cultural groups in Australia. Higher education curricula reviews have identified the need for institutions to incorporate Indigenous culture and knowledge more widely into the curricula to improve educational outcomes for Indigenous Australians and to increase cultural competence for all students...
December 30, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29282330/whole-genome-sequence-analyses-of-brain-imaging-measures-in-the-framingham-study
#19
Chloé Sarnowski, Claudia L Satizabal, Charles DeCarli, Achilleas N Pitsillides, L Adrienne Cupples, Ramachandran S Vasan, James G Wilson, Joshua C Bis, Myriam Fornage, Alexa S Beiser, Anita L DeStefano, Josée Dupuis, Sudha Seshadri
OBJECTIVE: We sought to identify rare variants influencing brain imaging phenotypes in the Framingham Heart Study by performing whole genome sequence association analyses within the Trans-Omics for Precision Medicine Program. METHODS: We performed association analyses of cerebral and hippocampal volumes and white matter hyperintensity (WMH) in up to 2,180 individuals by testing the association of rank-normalized residuals from mixed-effect linear regression models adjusted for sex, age, and total intracranial volume with individual variants while accounting for familial relatedness...
January 16, 2018: Neurology
https://www.readbyqxmd.com/read/29169731/a-composition-of-medicinal-plants-with-an-enhanced-ability-to-suppress-microsomal-lipid-peroxidation-and-a-protective-activity-against-carbon-tetrachloride-induced-hepatotoxicity
#20
Araylim N Aralbaeva, Aigul T Mamataeva, Nazgul I Zhaparkulova, Raisa S Utegalieva, Marina Khanin, Michael Danilenko, Maira K Murzakhmetova
Treatment of liver injury induced by various toxicants represents a serious clinical challenge. Here, we utilized the ability of natural agents to inhibit microsomal lipid peroxidation (LPO) as the in-vitro screening paradigm for selecting efficacious tissue-protective combinations of cooperatively acting medicinal plants. Based on screening of 70 water-ethanol extracts obtained from different parts of 65 plants we prepared a highly active phytocomposition (PC-1) containing oregano (Origanum vulgare), wild thyme (Thymus serpyllum) and coltsfoot (Tussilago farfara) aerial parts, valerian (Valeriana officinalis) leaves and little-leaf linden (Tilia cordata) flowers...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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