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Evidenced based medicine

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https://www.readbyqxmd.com/read/28914203/phytomedicines-are-efficient-complementary-therapies-for-the-treatment-of-atopic-dermatitis-a-review-of-mechanistic-insight-and-recent-updates
#1
Mohamad Aidil Tumpang, Nor Amlizan Ramli, Zahid Hussain
BACKGROUND: Phytomedicines have been well-accepted alternative complementary therapies for the treatment of a wide range of acute and chronic skin inflammatory diseases including chronic herpes, prurigo, psoriasis, and atopic dermatitis (AD). Plethora of in vitro and in vivo studies have evidenced the therapeutic viability of phytomedicines, polyherbal formulations, plant-based materials and their decoctions for the treatment of mild-to-severe AD. OBJECTIVE: This review was aimed to summarize and critically discuss the convincing evidence for the therapeutic effectiveness of phytomedicines for the treatment of AD and explore their anti-AD efficacy...
September 13, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28900317/evaluation-of-cytotoxicity-effects-of-oleo-gum-resin-and-its-essential-oil-of-ferula-assa-foetida-and-ferulic-acid-on-4t1-breast-cancer-cells
#2
Seyyed Majid Bagheri, Amir Abdian Asl, Ali Shams, Seyyed Ali Mirghanizadeh-Bafghi, Zeynab Hafizibarjin
BACKGROUND: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several clinically useful anticancer agents. AIM: In this study, we studied the growth inhibitory effect of asafoetida and its essential oil and ferulic acid on antitumor activity using mouse breast cancer cell line...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28899847/enhancing-seasonal-influenza-surveillance-topic-analysis-of-widely-used-medicinal-drugs-using-twitter-data
#3
Ireneus Kagashe, Zhijun Yan, Imran Suheryani
BACKGROUND: Uptake of medicinal drugs (preventive or treatment) is among the approaches used to control disease outbreaks, and therefore, it is of vital importance to be aware of the counts or frequencies of most commonly used drugs and trending topics about these drugs from consumers for successful implementation of control measures. Traditional survey methods would have accomplished this study, but they are too costly in terms of resources needed, and they are subject to social desirability bias for topics discovery...
September 12, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28884282/efficiency-analysis-of-integrated-public-hospital-networks-in-outpatient-internal-medicine
#4
Miguel Angel Ortíz-Barrios, Juan P Escorcia-Caballero, Fabián Sánchez-Sánchez, Fabio De Felice, Antonella Petrillo
Healthcare systems are evolving towards a complex network of interconnected services due to the increasing costs and the increasing expectations for high service levels. It is evidenced in the literature the importance of implementing management techniques and sophisticated methods to improve the efficiency of healthcare systems, especially in emerging economies. This paper proposes an integrated collaboration model between two public hospitals to reach the reduction of weighted average lead time in outpatient internal medicine department...
September 7, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28852136/high-predictive-values-of-rbc-membrane-based-diagnostics-by-biophotonics-in-an-integrated-approach-for-autism-spectrum-disorders
#5
Giorgia Giacometti, Carla Ferreri, Anna Sansone, Chryssostomos Chatgilialoglu, Carla Marzetti, Ellas Spyratou, Alexandros G Georgakilas, Marina Marini, Provvidenza M Abruzzo, Alessandra Bolotta, Alessandro Ghezzo, Renato Minguzzi, Annio Posar, Paola Visconti
Membranes attract attention in medicine, concerning lipidome composition and fatty acid correlation with neurological diseases. Hyperspectral dark field microscopy (HDFM), a biophotonic imaging using reflectance spectra, provides accurate characterization of healthy adult RBC identifying a library of 8 spectral end-members. Here we report hyperspectral RBC imaging in children affected by Autism Spectrum Disorder (ASD) (n = 21) compared to healthy age-matched subjects (n = 20), investigating if statistically significant differences in their HDFM spectra exist, that can comprehensively map a membrane impairment involved in disease...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28830252/macrophage-repolarization-using-emu-oil-based-electrospun-nanofibers-possible-application-in-regenerative-medicine
#6
Reza Zamani, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Nosratollah Zarghami
In the regenerative medicine therapies, the availability of engineered scaffolds that modulate inflammatory states is highly required. The aim of this study was to evaluate the efficiency of electrospun nanofibrous scaffolds containing natural substances with anti-inflammatory properties such as Emu oil (EO) to control inflammation and re-polarization of macrophages toward M2 anti-inflammatory phonotype. For this purpose, bead free and smooth EO-blended PCL/PEG electrospun nanofibrous mats were successfully fabricated and characterized using FE-SEM, FTIR, and Universal Testing Machine...
August 23, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28811974/ex-vivo-assessment-of-drug-response-on-breast-cancer-primary-tissue-with-preserved-microenvironments
#7
Manuele G Muraro, Simone Muenst, Valentina Mele, Luca Quagliata, Giandomenica Iezzi, Alexandar Tzankov, Walter P Weber, Giulio C Spagnoli, Savas D Soysal
Interaction between cancerous, non-transformed cells, and non-cellular components within the tumor microenvironment plays a key role in response to treatment. However, short-term culture or xenotransplantation of cancer specimens in immunodeficient animals results in dramatic modifications of the tumor microenvironment, thus preventing reliable assessment of compounds or biologicals of potential therapeutic relevance. We used a perfusion-based bioreactor developed for tissue engineering purposes to successfully maintain the tumor microenvironment of freshly excised breast cancer tissue obtained from 27 breast cancer patients and used this platform to test the therapeutic effect of antiestrogens as well as checkpoint-inhibitors on the cancer cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28798924/diagnostic-performance-of-high-resolution-computed-tomography-in-otosclerosis
#8
Todd Kanzara, Jagdeep Singh Virk
AIM: To determine the sensitivity and specificity of high resolution computed tomography (HRCT) in the diagnosis of otosclerosis. METHODS: A systematic literature review was undertaken to include Level I-III studies (Oxford Centre for Evidenced based Medicine) that utilised HRCT to detect histology confirmed otosclerosis. Quantitative synthesis was then performed. RESULTS: Based on available level III literature, HRCT has a relatively low sensitivity of 58% (95%CI: 49...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28754498/a-pragmatic-introduction-of-mindfulness-in-a-continuing-education-setting-exploring-personal-experience-bridging-to-professional-practice
#9
Maryanna D Klatt, Kellie Weinhold, Christopher A Taylor, Kayla Zuber, Cynthia J Sieck
CONTEXT: Continuing Medical Education and Continuing Professional Education (CME/CPE) provide a context through which to introduce practicing Healthcare Professionals (HCPs) to emerging mind/body approaches. OBJECTIVE: To introduce mindfulness to practicing HCPs for application in their practice through an experiential CME/CPE session. DESIGN: This descriptive study included surveys administered in the context of a CME/CPE session at professional meetings, as well as a three-month follow-up survey...
June 30, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28711702/development-of-a-series-of-novel-4-anlinoquinazoline-derivatives-possessing-quinazoline-skeleton-design-synthesis-egfr-kinase-inhibitory-efficacy-and-evaluation-of-anticancer-activities-in%C3%A2-vitro
#10
Jin Chang, Hongyu Ren, Mingxia Zhao, Yan Chong, Wenwen Zhao, Yong He, Yunling Zhao, Huabei Zhang, Chuanmin Qi
4-anilinoquinazoline-based derivatives represent an attractive scaffold for small molecular EGFR-TKIs in the field of medicinal chemistry. A series of novel heterocyclic substituted derivatives have been designed, synthesized and evaluated their antitumor bioactivities as potential EGFR-TKIs. Most of the new compounds exhibited certain efficient inhibition potency for proliferation of a panel of five human cancer cells with IC50 values at the low micromolar level, and some of them possessed good broad-spectrum inhibition activities, compared to Gefitinib...
July 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28664693/readiness-of-adolescents-to-use-genetically-modified-organisms-according-to-their-knowledge-and-emotional-attitude-towards-gmos
#11
Stanisław Lachowski, Anna Jurkiewicz, Piotr Choina, Magdalena Florek-Łuszczki, Agnieszka Buczaj, Małgorzata Goździewska
INTRODUCTION: Agriculture based on genetically modified organisms plays an increasingly important role in feeding the world population, which is evidenced by a considerable growth in the size of land under genetically modified crops (GM). Uncertainty and controversy around GM products are mainly due to the lack of accurate and reliable information, and lack of knowledge concerning the essence of genetic modifications, and the effect of GM food on the human organism, and consequently, a negative emotional attitude towards what is unknown...
June 7, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28638842/choosing-wisely-overnight-residents-approach-to-fever
#12
Jessica Howard-Anderson, Kristin Schwab, Roswell Quinn, Christopher J Graber
We surveyed internal medicine residents regarding how they approach febrile patients in cross-cover settings. Residents frequently use the term "full fever work-up," and rely on this for sign-out. Despite this, residents felt fever work-ups were not evidenced-based, and definitions of when and how to respond to a fever varied.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28608152/recovering-from-chronic-myeloid-leukemia-the-patients-perspective-seen-through-the-lens-of-narrative-medicine
#13
G Graffigna, I Cecchini, M Breccia, E Capochiani, R Della Seta, S Galimberti, A Melosi, F Simonetti, M Pizzuti, S F Capalbo, F Falzetti, P Mazza, N Di Renzo, L Mastrullo, D Rapezzi, E Orlandi, T Intermesoli, A Iurlo, E Pungolino, M Pacilli
PURPOSE: The main objective of this study is to gain a deeper understanding of how patients suffering from chronic myeloid leukemia (CML) cope with their illness. The study aims to reconstruct the subjective meaning-making process related to CML in order to gain insights into the impact the disease has on patients' emotions and everyday lives, as well as to explore the psychological impact of their being presented with the chance to suspend their therapy and recover from the disease. METHODS: Data were gathered from a qualitative study conducted in Italy on 158 Italian CML patients...
June 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28606335/atr-ftir-characterization-of-generic-brand-named-and-counterfeit-sildenafil-and-tadalafil-based-tablets-found-on-the-brazilian-market
#14
José Coelho Neto, Fernanda L C Lisboa
Viagra and Cialis are among the most counterfeited medicines in many parts of the world, including Brazil. Despite the many studies that have been made regarding discrimination between genuine and counterfeit samples, most published works do not contemplate generic and similar versions of these medicines and also do not explore excipients/adjuvants contributions when characterizing genuine and suspected samples. In this study, we present our findings in exploring ATR-FTIR spectral profiles for characterizing both genuine and questioned samples of several generic and brand-name sildenafil- and tadalafil-based tablets available on the Brazilian market, including Viagra and Cialis...
July 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28586346/3d-bioprinting-of-methacrylated-hyaluronic-acid-meha-hydrogel-with-intrinsic-osteogenicity
#15
Michelle T Poldervaart, Birgit Goversen, Mylene de Ruijter, Anna Abbadessa, Ferry P W Melchels, F Cumhur Öner, Wouter J A Dhert, Tina Vermonden, Jacqueline Alblas
In bone regenerative medicine there is a need for suitable bone substitutes. Hydrogels have excellent biocompatible and biodegradable characteristics, but their visco-elastic properties limit their applicability, especially with respect to 3D bioprinting. In this study, we modified the naturally occurring extracellular matrix glycosaminoglycan hyaluronic acid (HA), in order to yield photo-crosslinkable hydrogels with increased mechanical stiffness and long-term stability, and with minimal decrease in cytocompatibility...
2017: PloS One
https://www.readbyqxmd.com/read/28584214/study-on-language-rehabilitation-for-aphasia
#16
REVIEW
Zeng-Zhi Yu, Shu-Jun Jiang, Zi-Shan Jia, Hong-Yu Xiao, Mei-Qi Zhou
OBJECTIVE: The aim is to update our clinical recommendations for evidence-based language rehabilitation of people with aphasia, based on a systematic review of the literature from 1999 to 2015. DATA SOURCES: Articles referred to in this systematic review of the Medline and PubMed published in English language literatures were from 1998 to 2015. The terms used in the literature searches were aphasia and evidenced-based. STUDY SELECTION: The task force initially identified citations for 51 published articles...
June 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28560942/categorization-and-analysis-of-disaster-health-publications-an-inventory
#17
Marvin L Birnbaum, Sowmya Adibhatla, Olivia Dudek, Jessica Ramsel-Miller
Disaster Medicine is a relatively new discipline. Understanding of the current status of its science is needed in order to develop a roadmap for the direction and structure of future studies that will contribute to building the science of the health aspects of disasters (HADs). The objective of this study was to examine the existing, peer-reviewed literature relevant to the HADs to determine the status of the currently available literature underlying the science of the HADs. A total of 709 consecutive, peer-reviewed articles published from 2009-2014 in two disaster-health-related medical journals, Prehospital and Disaster Medicine (PDM) and Disaster Medicine and Public Health Preparedness (DMPHP), were examined...
May 31, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28494477/new-zealand-plastic-surgeons-life-time-contribution-to-peer-reviewed-literature
#18
Tess Brian, Brandon Adams
AIM: The New Zealand Medical Association commits the New Zealand doctor to evidence-based medicine, scholarship, teaching, collaboration and communication. To assess this commitment, one measure, contribution to the peer-reviewed literature, was examined for one group of New Zealand doctors: plastic surgeons. METHOD: Plastic surgeons with a current practising certificate were identified on the New Zealand medical register (April 2016). Scopus database was searched for publications by each...
May 12, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28355369/therapeutic-use-of-the-rebound-effect-of-modern-drugs-new-homeopathic-medicines
#19
Marcus Zulian Teixeira
The homeopathic treatment is based on the principle of therapeutic similitude, employing medicines that cause certain disorders to treat similar manifestations, stimulating a reaction of the organism against its own ailments. The occurrence of this secondary reaction of the organism, opposite in nature to the primary action of the medicines, is evidenced in the study of the rebound (paradoxical) effect of several classes of modern drugs. In this work, in addition to substantiate the principle of similitude before the experimental and clinical pharmacology, we suggest a proposal to employ hundreds of conventional drugs according to homeopathic method, applying the therapeutic similitude between the adverse events of medicines and the clinical manifestations of patients...
February 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28315043/the-intensive-care-medicine-clinical-research-agenda-in-paediatrics
#20
REVIEW
Mark J Peters, Andrew Argent, Marino Festa, Stéphane Leteurtre, Jefferson Piva, Ann Thompson, Douglas Willson, Pierre Tissières, Marisa Tucci, Jacques Lacroix
BACKGROUND: Intensive Care Medicine set us the task of outlining a global clinical research agenda for paediatric intensive care (PIC). In line with the clinical focus of this journal, we have limited this to research that may directly influence patient care. METHODS: Clinician researchers from PIC research networks of varying degrees of formality from around the world were invited to answer two main questions: (1) What have been the major recent advances in paediatric critical care research? (2) What are the top 10 studies for the next 10 years? RESULTS: (1) Inclusive databases are well established in many countries...
March 17, 2017: Intensive Care Medicine
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