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https://www.readbyqxmd.com/read/28500507/impact-of-severe-hematological-abnormalities-in-the-outcome-of-hospitalized-patients-with-influenza-virus-infection
#1
A Lalueza, H Trujillo, J Laureiro, B Ayuso, P Hernández-Jiménez, C Castillo, M Torres, D Folgueira, O Madrid, C Díaz-Pedroche, E Arrieta, C Arévalo, C Lumbreras
Although hematological abnormalities have been described among patients with influenza virus infection, little is known about their impact on the outcome of the patients. The aim of this study was to assess the frequency and clinical impact of severe hematological abnormalities in patients with confirmed influenza virus infection. This was an observational retrospective study including all adult patients with diagnosis of influenza virus infection hospitalized from January to May 2016 in our institution. Influenza virus infection was diagnosed by means of rRT-PCR assay performed on respiratory samples...
May 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28491853/infection-associated-acute-interstitial-nephritis-a-case-report
#2
Rupesh Raina, Shirisha Ale, Tushar Chaturvedi, Luke Fraley, Robert Novak, Natthavat Tanphaichitr
BACKGROUND: Acute interstitial nephritis (AIN) is a clinico-pathological syndrome associated with a variety of infections, drugs, and sometimes with unknown causes. It is a common cause of acute kidney injury (AKI) and subsequent renal impairment, which often times is under-diagnosed. Infection-associated AIN occurs as a consequence of many systemic bacterial, viral, and parasitic infec-tions; however, its incidence has decreased significantly after the advent of antimicrobials. Infection-associated AIN presents with both oliguric or non-oliguric renal insufficiency, without the classical clinical triad of AIN (fever, rash, and arthralgia)...
March 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28468854/evaluation-of-aptima-zika-virus-assay
#3
Ping Ren, Daniel A Ortiz, Ana C B Terzian, Tatiana E Colombo, Mauricio L Nogueira, Nikos Vasilakis, Michael J Loeffelholz
The Zika virus (ZIKV) epidemic in the Americas poses a public health emergency that requires a swift response. Accurate and reliable ZIKV diagnostic tests serve as an important tool in limiting the spread of ZIKV infections. The Aptima Zika Virus assay (Hologic, Marlborough, MA) performed on the automated Panther system is a rapid and high-throughput method to detect ZIKV RNA using transcription-mediated amplification (TMA) technology. We evaluated the performance characteristics of the Aptima Zika Virus Assay on clinical serum and urine specimens (n=124) from two different patient populations, and samples spiked with ZIKV from three different lineages (n=10)...
May 3, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28455514/enterovirus-d68-subclade-b3-strain-circulating-and-causing-an-outbreak-in-the-united-states-in-2016
#4
Guiqing Wang, Jian Zhuge, Weihua Huang, Sheila M Nolan, Victoria L Gilrane, Changhong Yin, Nevenka Dimitrova, John T Fallon
In 2014 the United States experienced a nationwide outbreak of Enterovirus D68 (EV-D68) infection. There were no confirmed cases of EV-D68 in 2015 and CDC was only aware of limited sporadic EV-D68 detection in the US in 2016. In this report, we analyzed 749 nasopharyngeal (NP) specimens collected in 2015 and 2016 from patients in the Lower Hudson Valley, New York using a previously validated EV-D68-specific rRT-PCR assay. EV-D68 was detected in none of 199 NP specimens collected in 2015, and in one of 108 (0...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394987/-acute-glomerulonephritis-with-hemodialysis-requirement-secondary-to-influenza-a-h1n1pdm09-infection-report-of-two-cases
#5
Diana Aceituno, Alberto Fica, Rodrigo Fasce, Winston Andrade, Carolina Díaz
Acute renal failure (ARF) requiring hemodialysis is not common among patients affected by influenza. We report two unvaccinated adult patients with smoking habit, which were admitted with severe influenza A H1N1pdm09 that evolved with shock and required mechanical ventilation. Both patients developed progressive renal failure with oliguria/anuria, associated with urinary of inflammatory sediment with proteinuria, microhematuria and in one case also with hypocomplementemia, suggesting acute glomerulonephritis...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28390319/rapid-detection-of-avian-influenza-a-virus-by-immunochromatographic-test-using-a-novel-fluorescent-dye
#6
Seon-Ju Yeo, Bui Thi Cuc, Soon-Ai Kim, Do Thi Hoang Kim, Duong Tuan Bao, Trinh Thi Thuy Tien, Nguyen Thi Viet Anh, Do-Young Choi, Chom-Kyu Chong, Hak Sung Kim, Hyun Park
Sensitive and rapid diagnostic systems for avian influenza (AI) virus are required to screen large numbers of samples during a disease outbreak and to prevent the spread of infection. In this study, we employed a novel fluorescent dye for the rapid and sensitive recognition of AI virus. The styrylpyridine phosphor derivative was synthesized by adding allyl bromide as a stable linker and covalently immobilizing it on latex beads with antibodies generating the unique Red dye 53-based fluorescent probe. The performance of the innovative rapid fluorescent immnunochromatographic test (FICT) employing Red dye 53 in detecting the AI virus (A/H5N3) was 4-fold and 16-fold higher than that of Europium-based FICT and the rapid diagnostic test (RDT), respectively...
April 2, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28381304/evaluation-of-biosecurity-measures-to-prevent-indirect-transmission-of-porcine-epidemic-diarrhea-virus
#7
Yonghyan Kim, My Yang, Sagar M Goyal, Maxim C-J Cheeran, Montserrat Torremorell
BACKGROUND: The effectiveness of biosecurity methods to mitigate the transmission of porcine epidemic diarrhea virus (PEDV) via farm personnel or contaminated fomites is poorly understood. This study was undertaken to evaluate the effectiveness of biosecurity procedures directed at minimizing transmission via personnel following different biosecurity protocols using a controlled experimental setting. RESULTS: PEDV RNA was detected from rectal swabs of experimentally infected (INF) and sentinel pigs by real-time reverse transcription polymerase chain reaction (rRT-PCR)...
April 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28355409/life-saving-vascular-access-in-vascular-capital-exhaustion-single-center-experience-in-intra-atrial-catheters-for-hemodialysis
#8
Marta Pereira, Noélia Lopez, Iolanda Godinho, Sofia Jorge, Estela Nogueira, Fernando Neves, Alice Fortes, António G Costa
INTRODUCTION: Intra-atrial catheter (IAC) placement through an open surgical approach has emerged as a life-saving technique in hemodialysis (HD) patients with vascular access exhaustion. OBJECTIVE: To assess the complications of IAC placement, as well as patient and vascular access survival after this procedure. METHODS: The authors retrospectively analyzed all seven patients with vascular capital exhaustion, without immediate alternative renal replacement therapy (RRT), who underwent IAC placement between January 2004 and December 2015 at a single center...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28348777/fatal-case-of-co-infection-with-dengue-virus-and-neisseria-meningitidis-during-a-dengue-epidemic-in-the-state-of-rio-de-janeiro-brazil
#9
Ivano de Filippis, Priscila Conrado Guerra Nunes, Claudia Ferreira de Andrade, Bianca de Santis Gonçalves, Eliane Saraiva de Araújo, Itacirema de Oliveira Bezerra, Ivan Rocha Ferreira da Silva, Rita Maria Nogueira, Ana Maria Bispo de Filippis
INTRODUCTION: Dengue and meningococcal disease are caused by two different agents: a flavivirus and a Gram-negative bacterium, respectively. The first symptoms of both diseases can be indistinct and a rapid and accurate diagnosis is crucial, considering that both diseases are associated with high morbidity and mortality, representing a major public-health problem in Brazil. CASE PRESENTATION: We report a fatal case of co-infection of dengue virus (DENV) and Neisseria meningitidis in a 54-year-old patient...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28342740/the-development-of-a-real-time-reverse-transcription-polymerase-chain-reaction-rrt-pcr-assay-using-taqman-technology-for-the-pan-detection-of-bluetongue-virus-btv
#10
Catherine Mulholland, Michael J McMenamy, Bernd Hoffmann, Bernadette Earley, Bryan Markey, Joseph Cassidy, Gordon Allan, Michael D Welsh, John McKillen
Bluetongue virus (BTV) is an infectious, non-contagious viral disease of domestic and wild ruminants that is transmitted by adult females of certain Culicoides species. Since 2006, several serotypes including BTV-1, 2, 4, 6, 8, 9 and 16, have spread from the Mediterranean basin into Northern Europe for the first time. BTV-8 in particular, caused a major epidemic in northern Europe. As a result, it is evident that most European countries are at risk of BTV infection. The objective of this study was to develop and validate a real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) assay based on TaqMan technology for the detection of representative strains of all BTV serotypes...
March 23, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28333910/establishing-a-timeline-to-discontinue-routine-testing-of-asymptomatic-pregnant-women-for-zika-virus-infection-american-samoa-2016-2017
#11
W Thane Hancock, Heidi M Soeters, Susan L Hills, Ruth Link-Gelles, Mary E Evans, W Randolph Daley, Emily Piercefield, Magele Scott Anesi, Mary Aseta Mataia, Anaise M Uso, Benjamin Sili, Aifili John Tufa, Jacqueline Solaita, Elizabeth Irvin-Barnwell, Dana Meaney-Delman, Jason Wilken, Paul Weidle, Karrie-Ann E Toews, William Walker, Phillip M Talboy, William K Gallo, Nevin Krishna, Rebecca L Laws, Megan R Reynolds, Alaya Koneru, Carolyn V Gould
The first patients with laboratory-confirmed cases of Zika virus disease in American Samoa had symptom onset in January 2016 (1). In response, the American Samoa Department of Health (ASDoH) implemented mosquito control measures (1), strategies to protect pregnant women (1), syndromic surveillance based on electronic health record (EHR) reports (1), Zika virus testing of persons with one or more signs or symptoms of Zika virus disease (fever, rash, arthralgia, or conjunctivitis) (1-3), and routine testing of all asymptomatic pregnant women in accordance with CDC guidance (2,3)(...
March 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28330443/influenza-and-respiratory-syncytial-virus-in-infants-study-iris-of-hospitalized-and-non-ill-infants-aged-1-year-in-four-countries-study-design-and-methods
#12
Mark G Thompson, Danielle R Hunt, Ali K Arbaji, Artan Simaku, Veronica L Tallo, Holly M Biggs, Carolyn Kulb, Aubree Gordon, Ilham Abu Khader, Silvia Bino, Marilla G Lucero, Eduardo Azziz-Baumgartner, Pat Shifflett, Felix Sanchez, Basima I Marar, Ilirjana Bakalli, Eric A F Simões, Min Z Levine, Jennifer K Meece, Angel Balmaseda, Tareq M Al-Sanouri, Majlinda Dhimolea, Joanne N de Jesus, Natalie J Thornburg, Susan I Gerber, Lionel Gresh
BACKGROUND: This multi-country prospective study of infants aged <1 year aims to assess the frequency of influenza virus and respiratory syncytial virus (RSV) infections associated with hospitalizations, to describe clinical features and antibody response to infection, and to examine predictors of very severe disease requiring intensive care. METHODS/DESIGN: We are enrolling a hospital-based cohort and a sample of non-ill infants in four countries (Albania, Jordan, Nicaragua, and the Philippines) using a common protocol...
March 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28328944/respiratory-viruses-in-patients-with-influenza-like-illness-in-senegal-focus-on-human-respiratory-adenoviruses
#13
Mbayame Ndiaye Niang, Ndeye Sokhna Diop, Amary Fall, Davy E Kiori, Fatoumata Diene Sarr, Sara Sy, Déborah Goudiaby, Mamadou Aliou Barry, Malick Fall, Ndongo Dia
BACKGROUND: Human adenoviruses (HAdVs) are highly contagious pathogens that are associated with a wide spectrum of human illnesses involving the respiratory tract. In the present study, we investigate the epidemiologic and viral molecular features of HAdVs circulating in Senegal after 4 consecutive years of sentinel surveillance of influenza-like Illness cases. METHODOLOGY AND RESULTS: From January 2012 to December 2015 swabs were collected from consenting ILI outpatients...
2017: PloS One
https://www.readbyqxmd.com/read/28297057/dialysis-access-issues-related-to-conversion-from-peritoneal-dialysis-to-hemodialysis-and-vice-versa
#14
Maurizio Gallieni, Antonino Giordano, Anna Ricchiuto, Davide Gobatti, Maurizio Cariati
ABSTRACTHemodialysis (HD) and peritoneal dialysis (PD) represent two complementary modalities of renal replacement therapy (RRT) for end-stage renal disease patients. Conversion between the two modalities is frequent and more likely to happen from PD to HD. Every year, 10% of PD patients convert to HD, suggesting the need for recommendations on how to proceed with the creation of a vascular access in these patients. Criteria for selecting patients who would likely fail PD, and therefore take advantage of a backup access, are undefined...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28214758/comparative-analysis-of-viral-shedding-in-pediatric-and-adult-subjects-with-central-nervous-system-associated-enterovirus-infections-from-2013-to-2015-in-switzerland
#15
S Cordey, M Schibler, A G L'Huillier, N Wagner, A R Gonçalves, J Ambrosioni, S Asner, L Turin, K M Posfay-Barbe, L Kaiser
BACKGROUND: Several enterovirus (EV) genotypes can result in aseptic meningitis, but their routes of access to the central nervous system remain to be elucidated and may differ between the pediatric and adult populations. OBJECTIVE: To assess the pattern of viral shedding in pediatric and adult subjects with acute EV meningitis and to generate EV surveillance data for Switzerland. STUDY DESIGN: All pediatric and adult subjects admitted to the University Hospitals of Geneva with a diagnosis of EV meningitis between 2013 and 2015 were enrolled...
April 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28191331/development-of-dual-taqman-based-one-step-rrt-pcr-assay-panel-for-rapid-and-accurate-diagnostic-test-of-mers-cov-a-novel-human-coronavirus-ahead-of-hajj-pilgrimage
#16
Mohammad Sadegh Hashemzadeh, Rahimeh Rasouli, Bentolhoda Zahraei, Morteza Izadi, Mahdi Tat, Seyed Hassan Saadat, Mohammad Najarasl, Behzad Khansari Nejad, Ruhollah Dorostkar
BACKGROUND: Coronaviruses (CoVs) are large ribonucleic acid (RNA) viruses causing primarily respiratory disease in humans. A novel human coronavirus, subsequently named middle east respiratory syndrome coronavirus (MERS-CoV), was first reported in Saudi Arabia in September of 2012. With increasing numbers of infections and deaths from MERS-CoV, development of a rapid and reliable kit was crucial to prevent further spread of MERS-CoV. OBJECTIVES: In this study, we present two real-time reverse-transcription polymerase chain reaction (rRT-PCR) assays for in-house rapid and sensitive diagnostic testing of MERS-CoV, detecting the regions upstream of the envelope gene (upE) and open reading frame (ORF) 1b, respectively, for initial screening and final confirmation of MERS-CoV infection, as recommended by the world health organization (WHO)...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28177195/high-incidence-of-zika-virus-infection-detected-in-plasma-and-cervical-cytology-specimens-from-pregnant-women-in-guayaquil-ecuador
#17
Hector Zambrano, Jesse Waggoner, Karina León, Benjamin Pinsky, Ketty Vera, Marissa Schettino, Lisette Rivera, José Landivar, María Granda, Angela Lee, Gil Mor
Zika virus (ZIKV) infection during pregnancy has been linked to severe birth defects, and the epidemiologic situation of the ZIKV epidemic in Ecuador is poorly understood. Guayaquil, Ecuador, has a tropical climate and experiences frequent outbreaks of dengue and chikungunya virus, and in December 2015, ZIKV was identified. Given the well-documented effects of ZIKV in pregnancy, including microcephaly, we tested for the presence of ZIKV in both plasma and cervical cytology of pregnant women. We report the identification of a population of pregnant women with a high incidence of ZIKV infection detected in the plasma and lower reproductive tract...
February 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28077093/evaluation-of-the-point-of-care-becton-dickinson-veritor%C3%A2-rapid-influenza-diagnostic-test-in-kenya-2013-2014
#18
Linus K Ndegwa, Gideon Emukule, Timothy M Uyeki, Eunice Mailu, Sandra S Chaves, Marc-Alain Widdowson, Bandika V Lewa, Francis K Muiruri, Peter Omoth, Barry Fields, Joshua A Mott
BACKGROUND: We evaluated the performance of the Becton Dickinson Veritor™ System Flu A + B rapid influenza diagnostic test (RIDT) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in Kenya, a tropical country where influenza seasonality is variable. METHODS: Nasal swab (NS) and nasopharyngeal (NP)/oropharyngeal (OP) swabs were collected from patients with influenza like illness and/or severe acute respiratory infection...
January 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28025746/gender-specific-differences-in-baseline-peak-and-delta-serum-creatinine-the-nacseld-experience
#19
Jacqueline G O'Leary, Florence Wong, K Rajender Reddy, Guadalupe Garcia-Tsao, Patrick S Kamath, Scott W Biggins, Michael B Fallon, Ram M Subramanian, B Maliakkal, Leroy Thacker, Jasmohan S Bajaj
BACKGROUND: Women have lower serum creatinine values than men for similar renal function. AIMS: We aimed to determine the differential effect of baseline, peak, and delta creatinine between genders on outcomes in infected hospitalized cirrhotic patients. METHODS: North American Consortium for the Study of End-Stage Liver Disease is a 15-center consortium of tertiary care hepatology centers prospectively enrolling infected cirrhotic inpatients...
March 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27995031/simultaneous-detection-of-influenza-a-subtypes-of-h3n2-virus-pandemic-h1n1-2009-virus-and-reassortant-avian-h7n9-virus-in-humans-by-multiplex-one-step-real-time-rt-pcr-assay
#20
Dawei Cui, Dejian Zhao, Guoliang Xie, Xianzhi Yang, Zhaoxia Huo, Shufa Zheng, Fei Yu, Yu Chen
BACKGROUND: Influenza A virus is a leading causative pathogen of human acute respiratory infection. Recently, the co-circulation of pandemic (H1N1) 2009 and seasonal H3N2 viruses was reported, and sporadic cases with reassortant avian H7N9 virus are continually reported in China. We aimed to establish a multiplex one-step real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay to simultaneously detect and discriminate FluA subtypes, including human seasonal H3N2 virus, pandemic (H1N1) 2009 virus and reassortant avian H7N9 virus, in one reaction tube...
2016: SpringerPlus
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