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https://www.readbyqxmd.com/read/29214834/source-and-size-of-social-support-network-on-sedentary-behavior-among-older-adults
#1
Paul D Loprinzi, Elizabeth A Crush
PURPOSE: To examine the association of source of social support and size of social support network on sedentary behavior among older adults. DESIGN: Cross-sectional. SETTING: National Health and Nutrition Examination Survey 2003 to 2006. PARTICIPANTS: 2519 older adults (60+ years). MEASURES: Sedentary behavior was assessed via accelerometry over a 7-day period. Social support was assessed via self-report...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29209113/efficacy-of-thalidomide-therapy-in-pediatric-crohn-s-disease-with-evidence-of-tuberculosis
#2
Lin Wang, Yan Hong, Jie Wu, Ying-Kit Leung, Ying Huang
AIM: To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn's disease (CD) with tuberculosis infection. METHODS: A retrospective study of clinical outcome among children treated with thalidomide was conducted. All patients had evidence of tuberculosis infection with a failure of anti-tuberculosis treatment for more than one year, and were subsequently diagnosed with CD. All the patients received thalidomide treatment with a starting dose of 1...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29205264/diet-physical-activity-or-both-for-prevention-or-delay-of-type-2-diabetes-mellitus-and-its-associated-complications-in-people-at-increased-risk-of-developing-type-2-diabetes-mellitus
#3
REVIEW
Bianca Hemmingsen, Gabriel Gimenez-Perez, Didac Mauricio, Marta Roqué I Figuls, Maria-Inti Metzendorf, Bernd Richter
BACKGROUND: The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether diet, physical activity or both can prevent or delay T2DM and its associated complications in at-risk people is unknown. OBJECTIVES: To assess the effects of diet, physical activity or both on the prevention or delay of T2DM and its associated complications in people at increased risk of developing T2DM. SEARCH METHODS: This is an update of the Cochrane Review published in 2008...
December 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29192424/interventions-for-old-world-cutaneous-leishmaniasis
#4
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Ludovic Reveiz, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
December 1, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29149474/interventions-for-old-world-cutaneous-leishmaniasis
#5
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29145543/association-of-ipilimumab-with-safety-and-antitumor-activity-in-women-with-metastatic-or-recurrent-human-papillomavirus-related-cervical-carcinoma
#6
Stephanie Lheureux, Marcus O Butler, Blaise Clarke, Mihaela C Cristea, Lainie P Martin, Katia Tonkin, Gini F Fleming, Anna V Tinker, Hal W Hirte, Daliah Tsoref, Helen Mackay, Neesha C Dhani, Prafull Ghatage, Johanne Weberpals, Stephen Welch, Nhu-An Pham, Vinicius Motta, Valentin Sotov, Lisa Wang, Katherine Karakasis, Smitha Udagani, Suzanne Kamel-Reid, Howard Z Streicher, Patricia Shaw, Amit M Oza
Importance: Based on evidence of human papillomavirus (HPV)-induced immune evasion, immunotherapy may be an attractive strategy in cervical cancer. Ipilimumab is a fully humanized monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4 (CTLA-4), which acts to downregulate the T-cell immune response. Objective: To assess the safety and antitumor activity of ipilimumab in recurrent cervical cancer. Design, Setting, and Participants: A multicenter trial was designed for patients with metastatic cervical cancer (squamous cell carcinoma or adenocarcinoma) with measurable disease and progression after at least 1 line of platinum chemotherapy...
November 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28922926/acupuncture-plus-herbal-medicine-for-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#7
Simin Zhou, Lanlan Dong, Yuan He, Hong Xiao
Alzheimer's disease (AD) is associated with the unprecedented aging tendency in our world population and has become a significant health issue. The use of Traditional Chinese Medicine to treat AD has been increasing in recent years. The objective of this meta-analysis is to evaluate the effectiveness of combining acupuncture with herbal medicine to treat AD. Randomized controlled trials (RCTs) of acupuncture plus herbals versus treatment with western drugs for AD were retrieved from 11 databases. The data were extracted by two authors; dichotomous data were expressed as odds ratio (ORs) and 95% confidence intervals (CIs), while continuous data were calculated by mean differences (MDs) with 95% CIs...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28884731/-optimization-of-the-algorithm-for-the-detection-and-the-differential-non-pharmacological-correction-of-the-risk-factors-and-the-preclinical-stages-of-atherosclerosis-at-the-level-of-the-health-resort-based-primary-care
#8
M A Vartazaryan, A T Bykov, A V Chernyshev, L S Khodasevich
This article presents the results of a comparative prospective study of 276 subjects at the age between 40 and 65 years presenting with risk factors (RF) of atherosclerosis and its preclinical stages (APC). All of them were reckoned to be at a moderate risk of developing APC based on the results of evaluation with the use of the SCORE scale which implied the necessity of their differential non-pharmacological treatment during a two-year period with the application of a variety of preventive therapeutic strategies...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28859716/non-rem-sleep-instability-in-children-with-primary-monosymptomatic-sleep-enuresis
#9
Leticia Azevedo Soster, Rosana Cardoso Alves, Simone Nascimento Fagundes, Adrienne Lebl, Eliana Garzon, Vera H Koch, Raffaele Ferri, Oliviero Bruni
STUDY OBJECTIVES: Sleep enuresis is one of the most common sleep disturbances in childhood. Parental perception of deeper sleep in children with sleep enuresis is not confirmed by objective studies. However, evidence of disturbed sleep has been demonstrated by questionnaire, actigraphy, and polysomnographic studies, but no neurophysiological correlation with low arousability has been found. The goal of this study was to analyze the sleep microstructure of children with sleep enuresis using cyclic alternating pattern (CAP) analysis...
October 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28817373/cabozantinib-as-salvage-therapy-for-patients-with-tyrosine-kinase-inhibitor-refractory-differentiated-thyroid-cancer-results-of-a-multicenter-phase-ii-international-thyroid-oncology-group-trial
#10
MULTICENTER STUDY
Maria E Cabanillas, Jonas A de Souza, Susan Geyer, Lori J Wirth, Michael E Menefee, Stephen V Liu, Komal Shah, John Wright, Manisha H Shah
Purpose Sorafenib and lenvatinib are oral multikinase inhibitors targeting vascular endothelial growth factor receptor (VEGFR) and approved for radioiodine (RAI)-refractory differentiated thyroid cancer (DTC). However, there are no approved second- or third-line therapies. MET is implicated in resistance to VEGFR inhibitors. Cabozantinib is an oral multikinase inhibitor targeting MET in addition to VEGFR and is approved for medullary thyroid cancer. In a phase I study of cabozantinib, five of eight patients with DTC previously treated with a VEGFR-targeted therapy had an objective response to cabozantinib...
October 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28791920/detection-of-malignancy-among-suspicious-thyroid-nodules-1%C3%A2-cm-on-ultrasound-with-various-thyroid-image-reporting-and-data-systems
#11
Su Min Ha, Jae Kyun Kim, Jung Hwan Baek
BACKGROUND: In patients undergoing active surveillance of papillary thyroid microcarcinoma, definitive therapy-usually preceded by a definitive diagnostic procedure-is not recommended until evidence of disease progression is obtained, as stated in the American Thyroid Association guidelines. This is because the deferring of definitive diagnosis and therapy until disease progression has no impact on the disease-specific survival. This study evaluated the malignancy rate and probability of thyroid nodules, which was further stratified based on the size cutoff value of 1 cm, with suspicious findings on ultrasonography (US), by using various malignant stratification systems...
October 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28780745/effectiveness-and-safety-of-dimethyl-fumarate-treatment-in-relapsing-multiple-sclerosis-patients-real-world-evidence
#12
Raed Alroughani, Samar Farouk Ahmed, Raed Behbehani, Jasem Al-Hashel
INTRODUCTION: Dimethyl fumarate (DMF) has been recently approved as a disease-modifying therapy for the treatment of multiple sclerosis (MS). Post-marketing studies are important to confirm what was established in clinical trials. OBJECTIVE: To evaluate effectiveness and safety of DMF and to measure the occurrence of lymphopenia in a cohort of MS patients in a clinical setting. METHODS: Using the national MS registry, we prospectively assessed relapsing MS patients who had been prescribed DMF for at least 6 months...
August 5, 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28771557/low-moderate-urine-arsenic-and-biomarkers-of-thrombosis-and-inflammation-in-the-strong-heart-study
#13
Katherine A Moon, Ana Navas-Acien, Maria Grau-Pérez, Kevin A Francesconi, Walter Goessler, Eliseo Guallar, Jason G Umans, Lyle G Best, Jonathan D Newman
The underlying pathology of arsenic-related cardiovascular disease (CVD) is unknown. Few studies have evaluated pathways through thrombosis and inflammation for arsenic-related CVD, especially at low-moderate arsenic exposure levels (<100 μg/L in drinking water). We evaluated the association of chronic low-moderate arsenic exposure, measured as the sum of inorganic and methylated arsenic species in urine (ΣAs), with plasma biomarkers of thrombosis and inflammation in American Indian adults (45-74 years) in the Strong Heart Study...
2017: PloS One
https://www.readbyqxmd.com/read/28535331/computer-and-mobile-technology-interventions-for-self-management-in-chronic-obstructive-pulmonary-disease
#14
REVIEW
Catherine McCabe, Margaret McCann, Anne Marie Brady
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterised by airflow obstruction due to an abnormal inflammatory response of the lungs to noxious particles or gases, for example, cigarette smoke. The pattern of care for people with moderate to very severe COPD often involves regular lengthy hospital admissions, which result in high healthcare costs and an undesirable effect on quality of life. Research over the past decade has focused on innovative methods for developing enabling and assistive technologies that facilitate patient self-management...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28520460/the-influence-of-body-mass-index-on-outcomes-after-hip-arthroscopic-surgery-with-capsular-plication-for-the-treatment-of-femoroacetabular-impingement
#15
Bryan M Saltzman, Benjamin D Kuhns, Bryce Basques, Timothy Leroux, Jennifer Alter, Richard C Mather, Michael J Salata, Shane J Nho
BACKGROUND: It remains unknown how variations in body mass index (BMI) influence outcomes after primary hip arthroscopic surgery with capsular plication for femoroacetabular impingement (FAI). PURPOSE: To evaluate the effect that abnormal BMI (namely, overweight, obese, morbidly obese, and underweight) versus normal weight has on patient-reported clinical outcomes more than 2 years postoperatively from primary hip arthroscopic surgery with capsular plication by a single surgeon...
August 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28516234/assessing-long-term-return-to-play-after-hip-arthroscopy-in-football-players-evaluating-risk-factors-for-good-prognosis
#16
D Barastegui, R Seijas, P Alvarez-Diaz, E Rivera, E Alentorn-Geli, G Steinbacher, X Cuscó, R Cugat
PURPOSE: Groin pain is the third most common disease in football players and has often been associated with hip pathology such as femoroacetabular impingement and labral lesions. Hip arthroscopy offers possibilities of function restoration via minimally invasive procedures. The aim of this study is to evaluate professional football player's injuries and their return to play after hip arthroscopy for FAI and labral injuries. METHODS: Patients that underwent hip arthroscopy between 2009 and 2014 were selected retrospectively...
May 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28502420/cardiopulmonary-exercise-testing-and-second-line-pulmonary-function-tests-to-detect-obstructive-pattern-in-symptomatic-smokers-with-borderline-spirometry
#17
Fabiano Di Marco, Silvia Terraneo, Sara Job, Rocco Francesco Rinaldo, Giuseppe Francesco Sferrazza Papa, Maria Adelaide Roggi, Pierachille Santus, Stefano Centanni
BACKGROUND: The need for additional research on symptomatic smokers with normal spirometry has been recently emphasized. Albeit not meeting criteria for Chronic obstructive pulmonary disease (COPD) diagnosis, symptomatic smokers may experience activity limitation, evidence of airway disease, and exacerbations. We, therefore, evaluated whether symptomatic smokers with borderline spirometry (post-bronchodilator FEV1/FVC ratio between 5th to 20th percentile of predicted values) have pulmonary function abnormalities at rest and ventilatory constraints during exercise...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28449645/24-month-clinical-outcomes-of-a-treat-and-extend-regimen-with-ranibizumab-for-wet-age-related-macular-degeneration-in-a-real-life-setting
#18
Athanasios Vardarinos, Nitin Gupta, Raazia Janjua, Abigail Iron, Theo Empeslidis, Konstantinos T Tsaousis
BACKGROUND: To evaluate the clinical effectiveness and analyze the outcomes of a treat-and-extend (T&E) treatment regimen with ranibizumab for wet age-related macular degeneration (ARMD) in real life clinical settings over the first 2 years (24 months) of treatment. METHODS: Retrospective analysis of visual acuity, spectral domain optical coherence tomography (SD-OCT) parameters and treatment burden data of 56 eyes of 54 unselected treatment naive patients diagnosed with exudative ARMD...
April 27, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28440858/treatment-with-disease-modifying-drugs-for-people-with-a-first-clinical-attack-suggestive-of-multiple-sclerosis
#19
REVIEW
Graziella Filippini, Cinzia Del Giovane, Marinella Clerico, Omid Beiki, Miriam Mattoscio, Federico Piazza, Sten Fredrikson, Irene Tramacere, Antonio Scalfari, Georgia Salanti
BACKGROUND: The treatment of multiple sclerosis has changed over the last 20 years. The advent of disease-modifying drugs in the mid-1990s heralded a period of rapid progress in the understanding and management of multiple sclerosis. With the support of magnetic resonance imaging early diagnosis is possible, enabling treatment initiation at the time of the first clinical attack. As most of the disease-modifying drugs are associated with adverse events, patients and clinicians need to weigh the benefit and safety of the various early treatment options before taking informed decisions...
April 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28436365/adverse-pathologic-characteristics-in-the-small-renal-mass-implications-for-active-surveillance
#20
Jamil S Syed, Cayce B Nawaf, James Rosoff, Campbell Bryson, Kevin A Nguyen, Alfredo Suarez-Sarmiento, Maria Serrano, Adam S Kibel, Peter Humphrey, Brian Shuch, Adebowale J Adeniran
INTRODUCTION: Evidence has demonstrated that tumor size is related to adverse oncologic outcomes in small renal tumors (≤ 4 cm). We evaluated the association of adverse pathologic features (APF) with tumor size and survival in patients with a small renal mass (SRM). MATERIALS AND METHODS: We retrospectively reviewed the pathologic characteristics of 380 surgically resected SRMs from a single institution. APFs included lymphovascular invasion, coagulative necrosis, sarcomatoid/rhabdoid features, papillary type II histology, and perinephric fat/renal sinus invasion...
April 2017: Canadian Journal of Urology
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