C M Westermann, M G M de Sain-van der Velden, J H van der Kolk, R Berger, I D Wijnberg, J P Koeman, R J A Wanders, J A Lenstra, N Testerink, A B Vaandrager, C Vianey-Saban, C Acquaviva-Bourdain, L Dorland
Two horses (a 7-year-old Groninger warmblood gelding and a six-month-old Trakehner mare) with pathologically confirmed rhabdomyolysis were diagnosed as suffering from multiple acyl-CoA dehydrogenase deficiency (MADD). This disorder has not been recognised in animals before. Clinical signs of both horses were a stiff, insecure gait, myoglobinuria, and finally recumbency. Urine, plasma, and muscle tissues were investigated. Analysis of plasma showed hyperglycemia, lactic acidemia, increased activity of muscle enzymes (ASAT, LDH, CK), and impaired kidney function (increased urea and creatinine)...
August 2007: Molecular Genetics and Metabolism