keyword
https://read.qxmd.com/read/38483594/biomarkers-for-urinary-tract-infection-present-and-future-perspectives
#21
REVIEW
Tej K Mattoo, John David Spencer
A prompt diagnosis of urinary tract infection (UTI) is necessary to minimize its symptoms and limit sequelae. The current UTI screening by urine test strip analysis and microscopic examination has suboptimal diagnostic accuracy. A definitive diagnosis of UTI by urine culture takes two to three days for the results. These limitations necessitate a need for better biomarkers for the diagnosis and subsequent management of UTI in children. Here, we review the value of currently available UTI biomarkers and highlight the potential of emerging biomarkers that can facilitate a more rapid and accurate UTI diagnosis...
March 14, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38483593/evaluation-and-post-transplant-management-of-children-after-multi-organ-with-kidney-transplantation
#22
REVIEW
Rachel M Engen, Caroline P Lemoine
Multi-organ transplantation involves the transplant of two or more organs from a single donor into a single recipient; in most cases, one of these organs is a kidney. Multi-organ transplantation is uncommon in pediatric transplantation but can be life-saving or significantly life-improving for children with rare diseases, including primary heart, liver, pancreas, or intestinal failure with secondary kidney failure, metabolic disorders, and genetic conditions causing multi-organ dysfunction. This manuscript reviews the current state of pediatric multi-organ transplantation that includes a kidney, with a focus on indications, evaluation, and key differences in management compared to kidney-alone transplantation...
March 14, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38478172/nail-patella-syndrome-with-nephropathy-in-a-de-novo-lmx1b-mutation-triangular-lunula-of-the-thumb-and-lack-of-finger-creases-as-clues
#23
JOURNAL ARTICLE
Yoshinori Banno, Masako Ikemiyagi, Riku Hamada, Kandai Nozu, Kentaro Matsuoka, Isamu Kamimaki
Nail-patella syndrome (NPS) is an autosomal dominant disease caused mostly by mutations in the LMX1B gene and is characterized by hypoplastic nails, hypoplastic patella, elbow deformities, glaucoma, and nephropathy, sometimes leading to kidney failure. The combination and the severity of symptoms vary greatly from patient to patient. Because a kidney biopsy may show nonspecific findings, patients with nephropathy alone may not be diagnosed without undergoing genetic testing. We examined the case of a 6-year-old girl with persistent high proteinuria who was not diagnosed by kidney biopsy but had a diagnosis of a de novo mutation in the LMX1B gene following genetic testing...
March 13, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38477662/point-of-care-ultrasound-pocus-training-curriculum-for-pediatric-nephrology-pcrrt-iconic-group-recommendations
#24
JOURNAL ARTICLE
Sidharth Kumar Sethi, John Mahan, Jieji Hu, Abhilash Koratala, Kritika Soni, Yogen Singh, Carolyn Abitbol, Marissa DeFreitas, Nathaniel Reisinger, Eduardo R Argaiz, Hui Kim Yap, Hamidreza Badeli, Meenal Kalra, Jonathan VanGeest, Nikhil Nair, James Raynor, Khalid A Alhasan, Mignon McCulloch, Timothy Bunchman, Vivek Sharma, Rupesh Raina
BACKGROUND: Point of care ultrasound (POCUS) is commonly used in adult specialties, pediatric emergency medicine, and neonatal and pediatric critical care. Specifically, in the field of pediatric nephrology, POCUS plays a valuable role in the critical inpatient and outpatient settings. However, the lack of guidelines and a standardized curriculum for POCUS in pediatric nephrology has led to substantial discrepancies in both clinical practice and training. METHODS: A multinational, multicenter survey regarding POCUS usefulness and training was sent to 225 pediatric nephrology residents, fellows, and physicians with expertise in pediatric nephrology...
March 13, 2024: Kidney360
https://read.qxmd.com/read/38472543/frequency-and-prognosis-of-peritoneal-dialysis-associated-peritonitis-in-children
#25
JOURNAL ARTICLE
Misaki Akiyama, Koichi Kamei, Kentaro Nishi, Tomoya Kaneda, Yuta Inoki, Kei Osaka, Mai Sato, Masao Ogura, Shuichi Ito
BACKGROUND: Peritonitis is the leading cause of peritoneal dialysis (PD) discontinuation. However, few data concern risk factors of peritonitis development and catheter removal caused by treatment failure in pediatric patients. METHODS: This single-center, retrospective study analyzed data from pediatric patients who underwent chronic PD between March 2002 and June 2022. The incidence rates of peritonitis by the person-year method were calculated, and they were stratified by patient age groups...
March 12, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38470876/establishing-age-and-gender-specific-serum-creatinine-reference-ranges-for-thai-pediatric-population
#26
JOURNAL ARTICLE
Sakon Suwanrungroj, Parichart Pattarapanitchai, Sirinart Chomean, Chollanot Kaset
Accurate assessment of kidney function in children requires age and gender-specific reference ranges for serum creatinine. Traditional reference values, often derived from adult populations and different ethnic backgrounds, may not be suitable for children. This study aims to establish specific reference ranges for serum creatinine in the Thai pediatric population, addressing the gap in localized and age-appropriate diagnostic criteria. This retrospective study analyzed serum creatinine levels from Thai children aged newborn to 18 years, collected from the Laboratory Information System of the Queen Sirikit National Institute of Child Health from January 2017 to December 2021...
2024: PloS One
https://read.qxmd.com/read/38467926/renal-coloboma-syndrome-dominant-optic-atrophy-with-severe-retinal-atrophy-and-de-novo-digenic-mutations-in-pax2-and-opa1
#27
JOURNAL ARTICLE
Wataru Shimabukuro, Yasutsugu Chinen, Naoya Imanaga, Kumiko Yanagi, Tadashi Kaname, Koichi Nakanishi
Renal coloboma syndrome (RCS) and dominant optic atrophy are mainly caused by heterozygous mutations in PAX2 and OPA1, respectively. We describe a patient with digenic mutations in PAX2 and OPA1. A female infant was born without perinatal abnormalities. Magnetic resonance imaging at 4 months of age showed bilateral microphthalmia and optic nerve hypoplasia. Appropriate body size was present at 2 years of age, and mental development was favorable. Color fundus photography revealed severe retinal atrophy in both eyes...
March 11, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38462547/fibrosing-colonopathy-associated-with-cysteamine-bitartrate-delayed-release-capsules-in-cystinosis-patients
#28
JOURNAL ARTICLE
Omayma A Kishk, Ivone Kim, Carmen Cheng, Mukesh Summan, Monica A Muñoz
BACKGROUND: The objective of this report is to identify and characterize cases of fibrosing colonopathy, a rare and underrecognized adverse event, associated with cysteamine delayed-release (DR) in patients with nephropathic cystinosis. METHODS: We searched the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) and the medical literature for postmarketing reports of fibrosing colonopathy associated with cysteamine through August 2, 2023. RESULTS: We identified four cases of fibrosing colonopathy reported with the use of cysteamine DR...
March 11, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38459510/health-related-quality-of-life-and-self-reported-health-status-in-adolescents-with-chronic-health-conditions-before-transfer-of-care-to-adult-health-care-an-international-cohort-study
#29
JOURNAL ARTICLE
Mira Kallio, Anna Tornivuori, Päivi J Miettinen, Kaija-Leena Kolho, Heikki Relas, Evelyn Culnane, Hayley Loftus, Susan M Sawyer, Silja Kosola
BACKGROUND: Heath-related quality of life (HRQoL) is lower in adolescents with chronic health conditions compared to healthy peers. While there is evidence of some differences according to the underlying condition and gender, differences by measure and country are poorly understood. In this study we focus on the differences in HRQoL in adolescents with various chronic medical conditions in the year before transfer of care to adult health services. We also study the associations of two different HRQoL measurements to each other and to self-reported health...
March 8, 2024: BMC Pediatrics
https://read.qxmd.com/read/38456918/common-mental-health-conditions-and-considerations-in-pediatric-chronic-kidney-disease
#30
JOURNAL ARTICLE
Katherine Mai, Anne E Dawson, Lidan Gu, Julia E LaMotte, Stephen Molitor, Cortney T Zimmerman
The mental health of youth with chronic kidney disease (CKD) has been increasingly recognized as an area of clinical need. The development of mental health concerns is influenced by a range of physiological, psychological, and environmental factors. Some of these factors are common across child development, but some are more unique to youth with CKD. Mental health concerns are associated with increased risk for a range of poor medical outcomes (e.g., adherence, risk of transplant rejection) and quality of life concerns...
March 8, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38456916/adalimumab-as-a-cause-of-kidney-injury-in-patients-with-crohn-s-disease
#31
JOURNAL ARTICLE
Krzysztof Skoczyński, Jan Koziej, Sylwia Szymańska, Łukasz Obrycki, Ryszard Grenda, Mieczysław Litwin
INTRODUCTION: Adalimumab (ADM) is a recombinant human monoclonal antibody (anti-TNFα) used to treat inflammatory bowel diseases. It can cause kidney injury (KI). CASE DIAGNOSIS/TREATMENT: We describe two pediatric patients with Crohn's disease (CD) in whom ADM therapy was associated with kidney injury (KI). The drug was discontinued in both cases. For the first patient, changes were irreversible despite intensive glucocorticosteroid (GCS) therapy. For the second patient, discontinuation of ADM led to an improvement in kidney function...
March 8, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38456915/assessment-of-south-asian-pediatric-acute-kidney-injury-epidemiology-and-risk-factors-aspire-a-prospective-study-on-severe-dialysis-dependent-pediatric-aki
#32
JOURNAL ARTICLE
Sidharth Kumar Sethi, Rupesh Raina, Ahmad Sawan, Sadaf Asim, Aye Kyawt Khant, Manoj Matnani, Kalaivani Ganesan, Shraddha Lohia, Rajiv Sinha, Jubaida Rumana, Syed Saimul Haque, Suprita Kalra, Rabia Safdar, Gopal Prasad, Iftikhar Ijaz, Omer S Ashruf, Aishwarya Nair, Savita S, Kritika Soni, Devendra Shrestha, Shankar Yadav, Asiri Abeyagunawardena, Valerie A Luyckx, Khalid A Alhasan, Azmeri Sultana
BACKGROUND: Pediatric acute kidney injury (AKI) is a global health concern with an associated mortality risk disproportionately pronounced in resource-limited settings. There is a pertinent need to understand the epidemiology of pediatric AKI in vulnerable populations. Here, we proposed a prospective study to investigate the epidemiology and associated risk factors of "severe dialysis dependent AKI" in children among South Asian nations which would be the first and largest of its kind...
March 8, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38454259/the-effect-of-unclassified-blood-pressure-phenotypes-on-left-ventricular-hypertrophy
#33
JOURNAL ARTICLE
Belde Kasap Demir, Cemaliye Başaran, Tülay Demircan, Gökçen Erfidan, Özgür Özdemir Şimşek, Seçil Arslansoyu Çamlar, Demet Alaygut, Fatma Mutlubaş, Cem Karadeniz
OBJECTIVE: We aimed to evaluate the clinical significance of the "unclassified" blood pressure phenotypes on left ventricular hypertrophy in children. MATERIALS AND METHODS: All children evaluated with ambulatory blood pressure monitoring in the pediatric nephrology department between October 2018 and January 2021 were included in the study. Prehypertension, normotensive, white coat hypertension, masked hypertension, ambulatory hypertension groups and 2 other groups including increased blood pressure load, normal ambulatory blood pressure measurements, but normal (unclassified group 1) or high (unclassified group 2) office blood pressure measurements were defined according to the American Heart Association 2014 statement...
January 2024: Turkish archives of pediatrics
https://read.qxmd.com/read/38452996/achieving-consensus-severity-graded-definitions-of-fontan-associated-complications-to-characterize-fontan-circulatory-failure
#34
JOURNAL ARTICLE
Kurt R Schumacher, Ari Cedars, Kiona Allen, David Goldberg, Adrianna Batazzi, Garrett Reichle, Frank DiPaola, David Selewski, Melissa Cousino, David N Rosenthal
BACKGROUND: Fontan physiology leads to chronic changes in other organ systems that may affect long-term survival and the success of heart transplantation. Inadequate assessment and treatment of the extra-cardiac effects of Fontan may contribute to poor outcomes. Severity graded/ordinal consensus definitions of Fontan complications are lacking which limits understanding of how Fontan-specific morbidity affects patient outcomes. METHODS AND RESULTS: A panel of Fontan patient and physiology experts, including pediatric, adult congenital, heart failure, and critical care cardiology, and pediatric nephrology, hepatology and psychology, convened to develop definitions of Fontan complications...
March 5, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38446208/acute-kidney-injury-requiring-dialysis-in-children-a-multicentric-emerging-country-perspective
#35
JOURNAL ARTICLE
Thais Lira Cleto-Yamane, Conrado Lysandro R Gomes, Paulo Cesar Koch-Nogueira, José Hermógenes Rocco Suassuna
BACKGROUND: Acute kidney injury (AKI) is a life-threatening condition, especially in extreme age groups and when kidney replacement therapy (KRT) is necessary. Studies worldwide report mortality rates of 10-63% in pediatric patients undergoing KRT. METHODS: Over 13 years, this multicenter study analyzed data from 693 patients with AKI, all receiving KRT, across 74 hospitals and medical facilities in Rio de Janeiro, Brazil. RESULTS: The majority were male (59...
March 6, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38438560/deriving-and-validating-a-protocol-to-determine-the-need-for-prophylactic-peritoneal-dialysis-in-neonates-after-cardiopulmonary-bypass-surgery
#36
JOURNAL ARTICLE
Tennille N Webb, Santiago Borasino, Kristal M Hock, Inmaculada Aban, Daryl Ingram, Kara Short, Robert Dabal, David Askenazi
BACKGROUND: Prophylactic peritoneal dialysis (PD) in neonates undergoing cardiopulmonary bypass (CPB) is safe and improves outcomes. We sought to (1) derive the pre-operative characteristics of neonates who are most likely to benefit from PD after CPB and (2) validate a new prophylactic PD protocol based on our retrospective analysis. METHODS: First, we retrospectively evaluated neonates requiring cardiac surgery with CPB from October 2012 to June 2016. We categorized neonates as those who "needed PD" and those who "did not need PD" based on prior experience with neonates requiring kidney support therapy...
March 4, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38436145/kidney-adolescent-and-young-adult-clinic-a-transition-model-in-africa
#37
REVIEW
Zibya Barday, Bianca Davidson, Paul Harden, Zakira Mukuddem-Sablay, Nicola Wearne, Erika S W Jones, Daley Cross, Mignon McCulloch
Adolescents and Young Adults (AYAs) with chronic kidney disease (CKD) have challenges unique to this developmental period, with increased rates of high-risk behavior and non-adherence to therapy which may impact the progression of kidney disease and their requirement for kidney replacement therapy (KRT). Successful transition of AYA patients are particularly important in low- and middle-income countries (LMICs) where KRT is limited, rationed or not available. Kidney AYA transition clinics have the potential to improve clinical outcomes but there is a paucity of data on the clinical translational impact of these clinics in Africa...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38428171/tuberous-sclerosis-complex-in-adulthood-focus-on-epilepsy-prognosis
#38
JOURNAL ARTICLE
Laura Licchetta, Giulia Bruschi, Carlotta Stipa, Laura Maria Beatrice Belotti, Lorenzo Ferri, Barbara Mostacci, Luca Vignatelli, Raffaella Minardi, Lidia Di Vito, Lorenzo Muccioli, Antonella Boni, Paolo Tinuper, Francesca Bisulli
OBJECTIVE: Typically diagnosed in early childhood or adolescence, TSC is a chronic, multisystemic disorder with age-dependent manifestations posing a challenge for transition and for specific surveillance throughout the lifetime. Data on the clinical features and severity of TSC in adults and on the prognosis of epilepsy are scarce. We analyzed the clinical and genetic features of a cohort of adult patients with TSC, to identify the prognostic predictors of seizure remission after a long follow-up...
February 29, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38427073/comparison-of-estimated-gfr-using-cystatin-c-versus-creatinine-in-pediatric-kidney-transplant-recipients
#39
JOURNAL ARTICLE
Helen Pizzo, John Nguyen, George J Schwartz, Katherine Wesseling-Perry, Robert Ettenger, Eileen Tsai Chambers, Patricia Weng
BACKGROUND: An accurate, rapid estimate of glomerular filtration rate (GFR) in kidney transplant patients affords early detection of transplant deterioration and timely intervention. This study compared the performance of serum creatinine (Cr) and cystatin C (CysC)-based GFR equations to measured GFR (mGFR) using iohexol among pediatric kidney transplant recipients. METHODS: CysC, Cr, and mGFR were obtained from 45 kidney transplant patients, 1-18 years old...
March 1, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38427072/kidney-volume-normative-values-in-central-european-children-aged-0-19%C3%A2-years-a-multicenter-study
#40
JOURNAL ARTICLE
Łukasz Obrycki, Jędrzej Sarnecki, Michał Pac, Marianna Lichosik, Małgorzata Sopińska, Małgorzata Placzyńska, Joanna Milart, Małgorzata Stańczyk, Julia Mirecka, Agnieszka Wasilewska, Maciej Michalski, Weronika Lewandowska, Tadeusz Dereziński, Terezie Šuláková, David Šupík, Andrius Čekuolis, Renata Vitkevič, Aldona Wierzbicka, Jan Koziej, Krzysztof Skoczyński, Jan Horubała, Augustina Jankauskiene, Bolesław Kalicki, Katarzyna Jobs, Marcin Tkaczyk, Janusz Feber, Mieczysław Litwin
BACKGROUND AND OBJECITVES: The currently available kidney volume normative values in children are restricted to small populations from single-centre studies not assessing kidney function and including none or only a small number of adolescents. This study aimed to obtain ultrasound-based kidney volume normative values derived from a large European White/Caucasian paediatric population with normal kidney function. METHODS: After recruitment of 1427 children aged 0-19 years, 1396 individuals with no history of kidney disease and normal estimated glomerular filtration rate were selected for the sonographic evaluation of kidney volume...
March 1, 2024: Pediatric Nephrology
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