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https://www.readbyqxmd.com/read/27924962/attenuation-of-unpredictable-chronic-mild-stress-induced-deficits-in-rats-by-apomorphine
#1
Muhammad Farhan, Darakshan Jabeen Haleem
OBJECTIVE: To investigate the effects of repeated doses of apomorphine in rats exposed to unpredictable chronic mild stress. METHODS: The experimental case-control study was conducted in March 2011 at the Department of Biochemistry, University of Karachi, and comprised albino-wistar rats. The experimental animals were exposed to a schedule of unpredictable chronic mild stress, while control animals were left in the cages. Animals of stressed and unstressed group were administrated with apomorphine at dose of 1...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27910716/persistent-amenorrhea-and-decreased-dheas-to-cortisol-ratio-after-recovery-from-anorexia-nervosa
#2
Alessandra Andrisani, Chiara Sabbadin, Silvia Minardi, Angela Favaro, Gabriella Donà, Luciana Bordin, Guido Ambrosini, Decio Armanini
Persistent amenorrhea is a frequent condition affecting anorexic patients after stable weight recovery. It has been proposed that it could be due to alterations of the hypothalamic-pituitary-gonadal axis linked with persistent hormonal impairments, such as relative hypercortisolemia and hypoleptinemia, and psychological symptoms related to anorexia nervosa (AN). The aim of our study was to evaluate the metabolic and hormonal pattern involved in the persistence of amenorrhea after recovery from AN. Eight weight-recovered anorexic patients with amenorrhea were investigated and matched with 10 healthy eumenorrhoic women, comparable for age and BMI...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27897393/cancer-anorexia-hypothalamic-activity-and-its-association-with-inflammation-and-appetite-regulating-peptides-in-lung-cancer
#3
Alessio Molfino, Alessandro Iannace, Maria Chiara Colaiacomo, Alessio Farcomeni, Alessandra Emiliani, Gianfranco Gualdi, Alessandro Laviano, Filippo Rossi Fanelli
BACKGROUND: Energy homeostasis is mediated by the hypothalamus, whose inflammation-induced functional derangements contribute to the onset of anorexia in cancer. By using functional magnetic resonance imaging (fMRI), we determined the patterns of hypothalamic activation after oral intake in anorexic (A), non-anorexic (NA) cancer patients, and in controls (C). METHODS: Lung cancer patients were considered. Hypothalamic activation was recorded in A and NA patients and in C by fMRI, before (T0), immediately after (T1) the administration of an oral nutritional supplement, and after 15 min (T2)...
October 5, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27890267/-the-silence-of-a-body-and-speech-set-free
#4
Maurice Corcos
Anorexia is a reflection of issues with the body in all its states. The social body and the representation of a model's body, mistreated in order to meet certain standards, the medical body shaken by the mystery of anorexia, and the subjective body and the reality of the flesh. The anorexic body is a testament to a past full of pain and neglect, a sign of emotional deficiency. Caring for the body of a person with anorexia, whatever the approach, means also and above all working with the future of a human being...
November 2016: Soins. Psychiatrie
https://www.readbyqxmd.com/read/27883233/intranasal-insulin-boosts-gustatory-sensitivity
#5
Rea Rodriguez-Raecke, Huan Yang, Yvonne F Brünner, Jessica Freiherr
Intranasal insulin had been in the spotlight not only for enhancing memory processes but also for its anorexic effects, as well as its effects on olfactory sensitivity. Here, the influence of intranasal insulin on gustatory sensitivity was investigated using intranasal applications of insulin or placebo in a double-blind manner alongside a control condition without any application. We hypothesized that intranasal insulin, as it mediates satiety, alters gustatory sensitivity whereas placebo application and control should not alter gustatory sensitivity...
November 24, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27834148/the-role-of-nuclear-receptor-ppar%C3%AE-in-the-sleep-wake-cycle-modulation-a-tentative-approach-for-treatment-of-sleep-disorders
#6
Eric Murillo-Rodriguez
There is a general consensus that sleep-wake cycle is controlled by neuroanatomical, neurochemical and molecular systems as well as by homeostatic and circadian complex networks. The research has shown that a molecular element that could be displaying a relevant role in the modulation of sleep is the peroxisome proliferator-activated receptor alpha (PPARα), which belongs to the family of nuclear receptor ligand-activated transcription factors that includes PPARβ/δ and PPARγ. A growing body of evidence supports the notion that PPARα is activated by natural ligands such as the anorexic lipid mediator oleoylethanolamide (OEA) or synthetic compounds including Wy14643 whereas antagonists like MK-886 block the neurobiological outcomes of PPARα...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27807376/the-use-of-serum-beta-hydroxybutyrate-to-determine-whether-nursery-pigs-selected-on-the-basis-of-clinical-signs-are-anorexic
#7
Amanda M Perri, Terri L O'Sullivan, John C S Harding, Robert M Friendship
The process of weaning pigs alters intestinal structures and influences piglet behavior, which can result in anorexia. When housed in large groups, affected pigs can be difficult to identify at an early stage. The clinical signs of anorexia include loss in body condition (thinness) and repetitive oral behavior (chomping). The objective of this study was to determine if pigs identified at 4 to 7 days post-weaning on the basis of clinical signs were anorexic based on elevated serum beta-hydroxybutyrate (BHB) levels (ketosis)...
November 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/27778196/orthorexic-eating-behaviour-as-a-coping-strategy-in-patients-with-anorexia-nervosa
#8
Friederike Barthels, Frank Meyer, Thomas Huber, Reinhard Pietrowsky
PURPOSE: Orthorexia nervosa is defined as the fixation on health-conscious eating behaviour and has recently been discussed as a new variant of disordered eating. The aim of the present study was to analyse orthorexic eating behaviour in an inpatient treatment sample of female anorexics to investigate the relation between anorexic and orthorexic eating behaviour. METHOD: Female anorexic patients with low (n = 29) and pronounced (n = 13) orthorexic eating behaviour as well as a matched control group composed of healthy females (n = 30) were compared with regard to several aspects of disordered eating, hypochondriacal traits, food consumption frequency and fulfilment of basic psychological needs in terms of eating...
October 24, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/27761691/-hunger-hurts-but-starving-works-the-moral-conversion-to-eating-disorders
#9
Gisella Orsini
This article aims to shed light on the self-perceptions of people with eating disorders in Malta and Italy through a deep understanding of their narratives. In contrast to the biomedical perception of the phenomenon and in opposition with the prevalent feminist theories on the subject, I consider eating disorders as the result of self-transformative processes. I suggest that anorexics, bulimics and binge eaters are actively and deliberately engaged in a project of moral self-transformation that is culturally defined...
October 19, 2016: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/27739190/an-integrative-bio-psycho-social-theory-of-anorexia-nervosa
#10
Calum Munro, Louise Randell, Stephen M Lawrie
: The need for novel approaches to understanding and treating anorexia nervosa (AN) is well recognized. The aim of this paper is to describe an integrative bio-psycho-social theory of maintaining factors in AN. We took a triangulation approach to develop a clinically relevant theory with face validity and internal consistency. We developed theoretical ideas from our clinical practice and reviewed theoretical ideas within the eating disorders and wider bio-psycho-social literature. The synthesis of these ideas and concepts into a clinically meaningful framework is described here...
October 13, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27729855/atypical-self-focus-effect-on-interoceptive-accuracy-in-anorexia-nervosa
#11
Olga Pollatos, Beate M Herbert, Götz Berberich, Michael Zaudig, Till Krauseneck, Manos Tsakiris
Background: Interoceptive abilities are known to be affected in anorexia nervosa (AN). Previous studies could show that private self-focus can enhance interoceptive accuracy (IAcc) in healthy participants. As body dissatisfaction is high in AN, confrontation with bodily features such as the own face might have a directly opposed effect in AN. Whether patients with AN can benefit from self-focus in their IAcc and whether this pattern changes over the time-course of cognitive behavioral therapy was investigated in this study...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27722184/the-physiological-role-of-the-brain-glp-1-system-in-stress
#12
Marie K Holt, Stefan Trapp
Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism's motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake...
December 31, 2016: Cogent Biology
https://www.readbyqxmd.com/read/27663886/high-fat-diet-induced-downregulation-of-anorexic-leukemia-inhibitory-factor-in-the-brain-stem
#13
Maria Licursi, Christian O Alberto, Alex Dias, Kensuke Hirasawa, Michiru Hirasawa
OBJECTIVE: High-fat diet (HFD) is known to induce low-grade hypothalamic inflammation. Whether inflammation occurs in other brain areas remains unknown. This study tested the effect of short-term HFD on cytokine gene expression and identified leukemia inhibitory factor (LIF) as a responsive cytokine in the brain stem. Thus, functional and cellular effects of LIF in the brain stem were investigated. METHODS: Male rats were fed chow or HFD for 3 days, and then gene expression was analyzed in different brain regions for IL-1β, IL-6, TNF-α, and LIF...
September 24, 2016: Obesity
https://www.readbyqxmd.com/read/27658828/pitfalls-in-anorexia-nervosa-research-the-risk-of-artifacts-linked-to-denial-of-illness-and-methods-of-preventing-them
#14
Małgorzata Starzomska, Ryszard Tadeusiewicz
One of the most serious problems faced by researchers studying eating disorders is denial of illness in individuals with anorexia nervosa. Importantly, the term "denial" not only has different meanings, but in the case of anorexia nervosa its very nature still remains obscure. It is not even known whether it is deliberate or unintentional. Denial of illness in anorexic patients has serious consequences for evaluation of the reliability of information obtained from those individuals. Indeed, the most frequently used screening questionnaires, such as the Eating Attitudes Test (EAT) (Garner & Garfinkel 1979) and the Eating Disorder Inventory (EDI) (Garner et al...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27646482/evidence-that-activation-of-nuclear-peroxisome-proliferator-activated-receptor-alpha-ppar%C3%AE-modulates-sleep-homeostasis-in-rats
#15
Eric Murillo-Rodríguez, Khalil Guzmán, Gloria Arankowsky-Sandoval, Mireille Salas-Crisóstomo, Ramsés Jiménez-Moreno, Oscar Arias-Carrión
The peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor superfamily that has been suggested as a modulator of several physiological functions. The PPARα recognizes as an endogenous ligand the anorexic lipid mediator oleoylethanolamide (OEA) which displays wake-inducing properties. Despite that recent evidence indicates that activation of PPARα by synthetic agonists such as Wy14643 enhances waking as well as the extracellular contents of wake-related neurotransmitters, the role of PPARα in sleep recovery after prolonged waking has not been fully described...
September 16, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27634717/teens-and-research
#16
Carolyn Plunkett Neuhaus
On seeing promising results in a small number of patients, some researchers are conducting trials to determine whether deep brain stimulation (DBS) is an effective treatment for anorexia nervosa (AN). This article asks whether we should open enrollment in trials of DBS for AN to adolescents. Despite concerns about informed consent, parental consent, and unforeseeable psychological sequelae, the article concludes that the risks to anorexic adolescents associated with participation in trials of DBS are reasonable considering the substantial risks of not enrolling teens with AN in research on DBS...
October 2016: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/27631979/gender-difference-in-bacteria-endotoxin-induced-inflammatory-and-anorexic-responses
#17
Shiu-Ming Kuo
Inflammation-related anorexic response has been observed in systemic diseases as well as in localized infection and is an important issue in patient care. We tested the hypothesis that upon the same endotoxin exposure, males have more severe inflammatory responses and thus suffer from more negative effect on appetite. Ten-week old male and female mice were compared in their plasma levels of pro-inflammatory cytokines after a body weight-based i.p. injection of bacterial endotoxin lipopolysaccharide. Male mice consistently showed significantly higher levels of IL6 and TNFα than female mice...
2016: PloS One
https://www.readbyqxmd.com/read/27594894/intact-social-cognitive-processes-in-outpatients-with-anorexia-nervosa-a-pilot-study
#18
Katarzyna Kucharska, Julia Jeschke, Reza Mafi
OBJECTIVE: The aim of the study was to assess social cognition in community patients suffering from anorexia nervosa (AN) compared to healthy controls. METHODS: 25 women diagnosed with AN and 25 women matched for education level and age were involved in the study. Both subject groups were assessed using a set of validated experimental tasks, such as the facial expression recognition test, short recognition memory test for faces, 'Reading the mind in the eyes' test...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27585115/the-acute-anorexic-effect-of-liraglutide-a-glp-1-receptor-agonist-does-not-require-functional-leptin-receptor-serotonin-and-hypothalamic-pomc-and-cart-activities-in-mice
#19
Katsunori Nonogaki, Takao Kaji
The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide.
October 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27579186/euglycemic-diabetic-ketoacidosis-in-a-patient-with-cocaine-intoxication
#20
Asma Abu-Abed Abdin, Muhammad Hamza, Muhammad S Khan, Awab Ahmed
Diabetic ketoacidosis (DKA) is characterized by elevated anion gap metabolic acidosis, hyperglycemia, and elevated ketones in urine and blood. Hyperglycemia is a key component of DKA; however, a subset of DKA patients can present with near-normal blood glucose, an entity described as "euglycemic DKA." This rare phenomenon is thought to be due to starvation and food restriction in insulin dependent diabetic patients. Cocaine abuse is considered a trigger for development of DKA. Cocaine also has anorexic effects...
2016: Case Reports in Critical Care
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