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red blood cell distribution

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https://www.readbyqxmd.com/read/28431401/combined-efficacy-of-c-reactive-protein-and-red-blood-cell-distribution-width-in-prognosis-of-patients-with-culture-negative-infective-endocarditis
#1
Xue-Biao Wei, Yuan-Hui Liu, Peng-Cheng He, Ying-Ling Zhou, Ning Tan, Ji-Yan Chen, Dan-Qing Yu
OBJECTIVE: To evaluate the combined effect of C-reactive protein (CRP) and red blood cell distribution width (RDW) on the prediction of in-hospital and long-term poor outcomes in patients with blood culture-negative infective endocarditis (BCNE). RESULTS: Patients with high CRP and high RDW has the highest incidence of in-hospital death (2.3% vs. 7.8% vs. 5.6% vs. 17.5%, P < 0.001). CRP > 17.8 mg/L (odds ratio [OR]=2.41, 95% confidence interval [CI], 1.06-5...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426586/predictive-modeling-of-massive-transfusion-requirements-during-liver-transplantation-and-its-potential-to-reduce-utilization-of-blood-bank-resources
#2
Aliaksei Pustavoitau, Maggie Lesley, Promise Ariyo, Asad Latif, April J Villamayor, Steven M Frank, Nicole Rizkalla, William Merritt, Andrew Cameron, Nabil Dagher, Benjamin Philosophe, Ahmet Gurakar, Allan Gottschalk
BACKGROUND: Patients undergoing liver transplantation frequently but inconsistently require massive blood transfusion. The ability to predict massive transfusion (MT) could reduce the impact on blood bank resources through customization of the blood order schedule. Current predictive models of MT for blood product utilization during liver transplantation are not generally applicable to individual institutions owing to variability in patient population, intraoperative management, and definitions of MT...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28425748/a-field-analysis-trial-comparing-the-turnaround-times-of-routine-and-stat-red-blood-cell-immunohematology-testing
#3
Katie Sackett, Andrea Kjell, Abigail M Schneider, Claudia S Cohn
The turnaround time (TAT) for pre-transfusion testing is important for prompt clinical decision-making. TAT includes the time between the arrival of the sample and the initiation of testing, plus the processing time (PT) required to generate and report a result. The TAT in larger blood banks is mostly dependent upon the capability of the analyzer used. In smaller blood banks, where manual work is often performed, the TAT is dependent on availability and experience of staff, testing resources, and workload. Our site performed a comparative analysis of the ORTHO VISION® (Ortho Clinical Diagnostics, Raritan, NJ) and the Echo® (Immucor, Norcross, GA) blood bank analyzers, using the TAT and PT of standard blood bank tests as the outcome metrics...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28409830/magnesium-for-treating-sickle-cell-disease
#4
REVIEW
Nan Nitra Than, Htoo Htoo Kyaw Soe, Senthil K Palaniappan, Adinegara Bl Abas, Lucia De Franceschi
BACKGROUND: Sickle cell disease is an autosomal recessive inherited haemoglobinopathy which causes painful vaso-occlusive crises due to sickle red blood cell dehydration. Vaso-occlusive crises are common painful events responsible for a variety of clinical complications; overall mortality is increased and life expectancy decreased compared to the general population. Experimental studies suggest that intravenous magnesium has proven to be well-tolerated in individuals hospitalised for the immediate relief of acute (sudden onset) painful crisis and has the potential to decrease the length of hospital stay...
April 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28406466/artificial-red-blood-cells-as-potential-photosensitizers-in-dye-laser-treatment-against-port-wine-stains
#5
REVIEW
Naoaki Rikihisa, Shoji Watanabe, Yoshiaki Saito, Hiromi Sakai
We suggest a novel method that uses artificial blood cells (hemoglobin vesicles, Hb-Vs) as photosensitizers in dye laser treatment (at 595-nm wavelength) for port-wine stains (i.e., capillary malformations presenting as red birthmarks) based on the results of animal experiments. As compared with human red blood cells, Hb-Vs have the same absorbance of 595 nm wavelength light and produce the same level of heat following dye laser irradiation. Small sized Hb-Vs (250 nm) distribute in the plasma phase in blood and tend to flow in the marginal zone of microvessels...
April 13, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28402329/no-evidence-for-loss-of-short-wavelength-sensitive-cone-photoreceptors-in-normal-ageing-of-the-primate-retina
#6
Tobias W Weinrich, Michael B Powner, Aisling Lynch, Ravi S Jonnal, John S Werner, Glen Jeffery
In old world primates including humans, cone photoreceptors are classified according to their maximal sensitivity at either short (S, blue), middle (M, green) or long (L, red) wavelengths. Colour discrimination studies show that the S-cone pathway is selectively affected by age and disease, and psychophysical models implicate their loss. Photoreceptors have high metabolic demand and are susceptible to age or disease-related losses in oxygen and nutrient supply. Hence 30% of rods are lost over life. While comparable losses are not seen in cones, S-cones comprise less than 10% of the cone population, so significant loss would be undetected in total counts...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28402168/performance-evaluation-of-automated-impedance-and-optical-fluorescence-platelet-counts-compared-with-international-reference-method-in-patients-with-thalassemia
#7
Chaicharoen Tantanate, Ladawan Khowawisetsut, Kovit Pattanapanyasat
CONTEXT: - Spurious platelet counts from automated methods have been reported in patients with abnormal red blood cells. However, there is no specific study regarding performance of platelet counts by automated methods in patients with thalassemia. OBJECTIVE: - To investigate the performance of automated platelet counts, including impedance (PLT-I) and optical fluorescent (PLT-O and PLT-F) methods, and compare them with the international reference method (IRM) for platelet counting in patients with thalassemia...
April 12, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28400547/anemia-in-thyroid-diseases
#8
Ewelina Szczepanek-Parulska, Aleksandra Hernik, Marek Ruchała
Anemia is a frequent, although often underestimated, clinical condition accompanying thyroid diseases. In spite of the fact that anemia and thyroid dysfunction often occur simultaneously, the causative relationship between these two disorders remains ambiguous. Thyroid hormones stimulate erythrocytes precursors proliferation directly, as well as via erythropoietin production enhancement, whereas iron-deficient anemia negatively influences thyroid hormonal status. Thus, different forms of anemia might emerge in the course of thyroid dysfunction...
March 28, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28396088/erythrocyte-aging-as-a-mechanism-of-anemia-and-a-biomarker-of-device-thrombosis-in-continuous-flow-left-ventricular-assist-devices
#9
Ziad Taimeh, Ryan J Koene, Julie Furne, Ashish Singal, Peter M Eckman, Michael D Levitt, Marc R Pritzker
BACKGROUND: Blood trauma caused by continuous-flow left ventricular assist devices (CF-LVADs) has been associated with device thrombosis and anemia. Accurate in vivo quantification of erythrocyte turnover and its contribution to CF-LVAD complications have yet to be elucidated. METHODS: We investigated the age (lifespan) of circulating erythrocytes in subjects with CF-LVAD. Erythrocyte lifespan is a quantitative indicator of in vivo erythrocyte turnover that can be accurately derived from measurement of the exhaled carbon monoxide (CO) level...
February 9, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28389880/role-of-climate-in-the-spread-of-shiga-toxin-producing-escherichia-coli-infection-among-children
#10
Fiorella Acquaotta, Gianluigi Ardissino, Simona Fratianni, Michela Perrone
Haemolytic-uraemic syndrome (HUS) is a rare disease mainly affecting children that develops as a complication of shiga toxin-producing Escherichia coli (STEC) infection. It is characterised by acute kidney injury, platelet consumption and mechanical destruction of red blood cells (haemolysis). In order to test the working hypothesis that the spread of the infection is influenced by specific climatic conditions, we analysed all of the identified cases of infection occurring between June 2010 and December 2013 in four provinces of Lombardy, Italy (Milano, Monza Brianza, Varese and Brescia), in which a STEC surveillance system has been developed as part of a preventive programme...
April 7, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28388534/prognostic-significance-of-the-red-blood-cell-distribution-width-in-diffuse-large-b-cell-lymphoma-patients
#11
Shujuan Zhou, Fang Fang, Huiyao Chen, Wei Zhang, Yang Chen, Yifen Shi, Zhouyi Zheng, Yongyong Ma, Liyuan Tang, Jianhua Feng, Yu Zhang, Lan Sun, Yi Chen, Bin Liang, Kang Yu, Songfu Jiang
This study examined the prognostic value of the baseline red blood cell distribution width (RDW) in diffuse large B cell lymphoma (DLBCL) patients. The associations between RDW and clinical characteristics were assessed in 161 DLBCL patients from 2005 to 2016. The log-rank test, univariate analysis, and Cox regression analysis were used to evaluate the relationship between RDW and survival. A RDW of 14.1% was considered to be the optimal cut-off value for predicting prognosis. A high RDW was associated with more frequent B symptoms (P=0...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28385032/the-transparency-of-irrigation-fluids-used-in-endoscopic-surgery
#12
Ilan Gielchinsky, Dov Pode, Mordechai Duvdevani, Vladimir Yutkin, Yehezkel Landau, Guy Hidas, Ofer N Gofrit
PURPOSE: Transurethral surgery has been traditionally done using the non-electrolyte, isotonic 1.5% glycine solution as irrigation fluid. The emergence of modern technologies, which can be applied with electrolyte solutions, such as bipolar resection and LASER evaporation, as well as the worry of transurethral resection syndrome have driven urologists away from glycine towards the use of normal saline. Differences in the transparencies of these fluids have not been studied. MATERIALS AND METHODS: The ability to resolve two bars at 1 mm apart using a 30 cystoscope lens immersed in different solutions was studied...
April 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28382854/lymphoma-classification-in-goats
#13
Patti K Kiser, Christiane V Löhr
Lymphoma has been described in individual cases for goats but not systematically characterized in a larger cohort. This study aimed to subtype caprine lymphoma based on topographic and subgross distribution, immunophenotype, and cellular morphology following the World Health Organization classification system for hematopoietic tumors in domestic animals. Fifteen caprine lymphoma cases were assessed with 6 submitted as biopsy and 9 for postmortem examination. Goats were predominantly young adult (median 3 years) and dwarf breeds (Pygmy and Pygora)...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28382694/quantitative-analysis-of-hyperpolarized-129-xe-gas-transfer-mri
#14
Ziyi Wang, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Elianna A Bier, Sudarshan Rajagopal, Yuh Chin Huang, Thomas G O'Riordan, Craig R Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: Hyperpolarized (129) Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of (129) Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize information from these images of pulmonary gas transfer are lacking. Here, we introduce a novel method to transform these data into quantitative maps of pulmonary ventilation, and (129) Xe gas transfer to barrier and RBC compartments...
April 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28379876/recombinant-von-willebrand-factor-for-severe-gastrointestinal-bleeding-unresponsive-to-other-treatments-in-a-patient-with-type-2a-von-willebrand-disease-a-case-report
#15
Racquel Brown
: A recombinant von Willebrand factor (rVWF) was recently approved in the United States for on-demand treatment and control of bleeding episodes in adults with von Willebrand disease (VWD). In contrast to plasma-derived VWF products available in the United States, rVWF does not contain factor VIII (FVIII). To date, there is no published experience of rVWF in clinical practice. We report the acute and prophylactic use of rVWF in a patient with VWD type 2A and severe gastrointestinal bleeding. Dosing with plasma-derived VWF/FVIII concentrates was constrained by FVIII accumulation; the bleeding was unresponsive, and multiple red blood cell transfusions were required...
April 4, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28367961/association-between-red-cell-distribution-width-and-mortality-in-patients-undergoing-continuous-ambulatory-peritoneal-dialysis
#16
Yao-Peng Hsieh, Shr-Mei Tsai, Chia-Chu Chang, Chew-Teng Kor, Chi-Chen Lin
Although red cell distribution width (RDW) has emerged as a biomarker of clinical prognostic value across a variety of clinical settings in the last two decades, limited evidence is available for its role in end-stage renal disease. We enrolled 313 incident patients undergoing continuous ambulatory peritoneal dialysis (CAPD) in this retrospective observational study from 2006 to 2015. In the fully adjusted model of Cox regression analysis, the adjusted hazard ratios for the high RDW group versus the low RDW group were 2...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28367174/does-obesity-cause-chronic-inflammation-the-association-between-complete-blood-parameters-with-body-mass-index-and-fasting-glucose
#17
Tuba Tulay Koca
OBJECTIVE: This study aimed to determine the relationship of complete blood count (CBC) parameters and derivates with fasting blood sugar and the body mass index. METHODS: This was a prospective, observational clinical study. Hospitalized patients who received a physiotherapy program in the Physical Medicine and Rehabilitation Clinic between March and June 2016 were included. The age, height, weight, body mass index (BMI), fasting blood glucose, erythrocyte sedimentation (ESR), C-reactive protein, and CBC parameters (leukocytes, platelets, neutrophil, lymphocytes, and monocytes) and red cell distribution width, platelet distribution width, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio of the patients were recorded...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28357630/age-structured-population-model-of-cell-survival
#18
Wojciech Krzyzanski, Pawel Wiczling, Asfiha Gebre
Age-structured cell population model was introduced to describe cell survival. The impact of the environment on the cell population is represented by drug plasma concentration. A key model variable is the hazard of cell removal that is a subject to the environment effect. The model is capable of describing cohort and random labeling cell survival data. In addition, it accounts for cell loss due to labeling of cell sample, but it lacks ability to describe the effect of label elution on the survival data. The model was applied to red blood cell (RBC) survival data in two groups of Wistar rats obtained by two techniques: cohort labeling using (14)C-glycine (N = 4) and random labeling using biotin (N = 8)...
March 29, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28353308/prognostic-value-of-red-blood-cell-distribution-width-in-patients-with-left-ventricular-systolic-dysfunction-insights-from-the-commit-hf-registry
#19
Jarosław Wasilewski, Łukasz Pyka, Michał Hawranek, Mateusz Tajstra, Michał Skrzypek, Michał Wasiak, Kamil Suliga, Kamil Bujak, Mariusz Gąsior
BACKGROUND: Previous studies have reported that in patients with heart failure, an increased value of red cell distribution width (RDW) is associated with adverse outcomes. Nonetheless, data regarding the association between RDW values and long-term mortality in patients with left ventricular systolic dysfunction (LVSD) are lacking. The aim of this investigation was to examine the relationship between mortality and RDW in patients with ischemic and non-ischemic LVSD. METHODS: Under analysis was 1734 patients with a left ventricular ejection fraction (LVEF) ≤ 35% of whom were hospitalized between 2009 and 2013...
March 29, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28350034/spectrophotometric-analysis-at-the-single-cell-level-elucidating-dispersity-within-melanic-immortalized-cell-populations
#20
Luis Polo-Parada, Gerardo Gutiérrez-Juárez, David Cywiak, Rafael Pérez-Solano, Gary A Baker
It is widely held that the melanosome is an exemplar of the absorption features of melanin-containing cells, which are assumed to be uniform in both size and optical characteristics. In recent years, however, it has become increasingly apparent that this is a strikingly poor assumption. Indeed, melanin extracted from natural sources and synthetic melanin both show wide variability in their degree of polymerization (molecular weight) and spectroscopic characteristics. In the current study, imaging spectrophotometry performed on individual cells of immortalized melanin-producing cell lines revealed broad distributions in their sizes: 9...
March 28, 2017: Analyst
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