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red blood cell distribution

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https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#1
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29772759/human-babesiosis-caused-by-babesia-duncani-has-widespread-distribution-across-canada
#2
John D Scott, Catherine M Scott
Human babesiosis caused by Babesia duncani is an emerging infectious disease in Canada. This malaria-like illness is brought about by a protozoan parasite infecting red blood cells. Currently, controversy surrounds which tick species are vectors of B. duncani. Since the availability of a serological or molecular test in Canada for B. duncani has been limited, we conducted a seven-year surveillance study (2011⁻2017) to ascertain the occurrence and geographic distribution of B. duncani infection country-wide...
May 17, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29770452/the-effects-of-blood-transfusion-on-red-blood-cell-distribution-width-in-critically-ill-patients-a-pilot-study
#3
Savino Spadaro, Fabio Silvio Taccone, Alberto Fogagnolo, Federico Franchi, Sabino Scolletta, Riccardo Ragazzi, Alberto Fanni, Elisabetta Marangoni, Maurizio Govoni, Roberto Reverberi, Carlo Alberto Volta
BACKGROUND: Red blood cell distribution width (RDW) is a measure of anisocytosis, generally used in the differential diagnosis of anemia. Recently, RDW was associated with increased mortality in critically ill patients. Red blood cell (RBC) transfusions are potential confounders on RDW values interpretation. The aim of this study was to analyze the changes in RDW after RBC transfusion in intensive care unit (ICU) patients. STUDY DESIGN AND METHODS: This was a prospective, observational study including patients admitted to ICU requiring 1 RBC unit...
May 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29770339/red-blood-cell-distribution-width-is-associated-with-carotid-atherosclerosis-in-people-with-type-2-diabetes
#4
J S Nam, C W Ahn, S Kang, K R Kim, J S Park
Aims: Red cell distribution width (RDW) has been shown to be associated with cardiovascular diseases (CVD). The relationship between RDW and carotid intima-media thickness (C-IMT), a marker of subclinical atherosclerosis, has been inconsistent in subjects with cardiovascular risk factors. In this study, we investigated the relationship between RDW and carotid atherosclerosis in people with type 2 diabetes. Methods: Four hundred sixty-nine people with type 2 diabetes without history of cardiovascular or cerebrovascular diseases were enrolled...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29769008/biochemical-and-haematological-predictors-of-reduced-neutrophil-granulocyte-count-associated-with-intravenous-ceftriaxone-treatment
#5
Basant Puri, Anne Derham, Jean Monro
Background Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia. Objective The first systematic study to determine whether six to 12 days' intravenous ceftriaxone treatment is associated with a reduction in the neutrophil count and the extent to which biochemical and/or haematological parameters routinely measured at baseline predict such a fall. Method Baseline and follow-up haematological and biochemical blood indices were measured in 86 patients (mean age 39...
May 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29767673/modeling-the-impact-of-folic-acid-fortification-and-supplementation-on-red-blood-cell-folate-concentrations-and-predicted-neural-tube-defect-risk-in-the-united-states-have-we-reached-optimal-prevention
#6
Krista S Crider, Yan Ping Qi, Owen Devine, Sarah C Tinker, Robert J Berry
Background: The US CDC and the Institute of Medicine recommend that women capable of becoming pregnant consume ≥400 µg synthetic folic acid/d to prevent neural tube defects (NTDs). The United States has 3 sources of folic acid: fortified enriched cereal grain products (ECGPs), fortified ready-to-eat (RTE) cereals, and dietary supplements. Objective: Our objectives were as follows: 1) to estimate the usual daily folic acid intake and distributions of red blood cell (RBC) folate concentrations among women consuming folic acid from different sources; 2) to assess the usual daily total folic acid intake associated with optimal RBC folate concentrations for NTD prevention; 3) to predict NTD prevalence; and 4) to estimate the number of preventable folate-sensitive NTDs...
May 14, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29761313/genomewide-dna-methylation-responses-in-patients-with-%C3%AE-thalassemia-treated-with-yisui-shengxue-granules
#7
Yan-Ling Cheng, Xin-Hua Zhang, Yu-Wen Sun, Wen-Juan Wang, Jie Huang, Na-Li Chu, Su-Ping Fang, Zhi-Kui Wu
OBJECTIVE: To examine the clinical effects of Yisui Shengxue Granules () in the treatment of β-thalassemia and explore its mechanism on DNA methylation levels. METHODS: A randomized placebo-controlled double-blinded trial was conducted. Forty patients with β-thalassemia were recruited and distributed randomly by envelope method into an experimental group and a control group, 20 patients in each group. The patients were given Yisui Shengxue Granules in the experimental group and placebo in the control group (12 g/bag three times a day) during a 3-month intervention...
May 3, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29760729/ceramic-hollow-fibre-constructs-for-continuous-perfusion-and-cell-harvest-from-3d-hematopoietic-organoids
#8
Mark C Allenby, Asma Tahlawi, José C F Morais, Kang Li, Nicki Panoskaltsis, Athanasios Mantalaris
Tissue vasculature efficiently distributes nutrients, removes metabolites, and possesses selective cellular permeability for tissue growth and function. Engineered tissue models have been limited by small volumes, low cell densities, and invasive cell extraction due to ineffective nutrient diffusion and cell-biomaterial attachment. Herein, we describe the fabrication and testing of ceramic hollow fibre membranes (HFs) able to separate red blood cells (RBCs) and mononuclear cells (MNCs) and be incorporated into 3D tissue models to improve nutrient and metabolite exchange...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29758192/gastric-mucosal-metastasis-of-prostate-cancer
#9
Hayretdin Koklu, Gokhan Gedikoglu, Taylan Kav
A 65-year-old male patient who had been hospitalized in the ıntensive care unit for pneumonia presented with hematemesis and melena. He was diagnosed with metastatic adenocarcinoma of prostate (multiple bone and lung metastases), which was accompanied by diabetes mellitus, hypertension, and coronary heart disease. The hemoglobin levels decreased from 11.4 g/dL to 7.3 g/dL during follow-up. Upper endoscopy revealed widespread distribution of numerous umbilicated nodules with varying sizes (from 0.5 to 2 cm) on gastric mucosa (A, B, C)...
May 11, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29745271/fetal-hemoglobin-in-the-maternal-circulation-contribution-of-fetal-red-blood-cells
#10
Mutaz Dana, Eitan Fibach
The major hemoglobin (Hb) during fetal life is fetal Hb (Hb F). It is mostly replaced by adult Hbs before birth and during the first year of life. In adults, where Hb F comprises <2.0% of the total Hb, it is not homogenously distributed among the red blood cells (RBCs) but is concentrated in a few RBCs, termed F-cells. Interestingly, for reasons that are unclear, Hb F increases in the maternal circulation during pregnancy. This increased Hb F could have two potential origins that are not mutually exclusive: A) maternal origin, due to inducing environment of Hb F in the maternal erythroid precursors; B) fetal origin, due to fetal cells crossing the placenta and entering the maternal circulation...
May 10, 2018: Hemoglobin
https://www.readbyqxmd.com/read/29744311/relationships-between-sedentary-behaviour-physical-activity-levels-and-red-blood-cell-distribution-width-in-children-and-adolescents
#11
Nevin Hammam, Victor E Ezeugwu, Patricia J Manns, Lesley Pritchard-Wiart
Background: Red blood cell distribution width (RDW) is a biomarker for cardiovascular disease(CVD). RDW is associated with sedentary behavior (SB) and physical activity (PA) in adults.To date, no study has evaluated this association in children. The purpose of this study was to evaluate the association between RDW and SB and PA levels of children and adolescents. Methods: This observational study included data from participants aged 12-20 years in the 2003-2006 National Health and Nutrition Examination Survey (NHANES)...
2018: Health Promotion Perspectives
https://www.readbyqxmd.com/read/29738349/a-pilot-study-of-pancreatic-islet-amyloid-pet-imaging-with-18f-fddnp
#12
Zhi Lu, Jinghui Xie, Ran Yan, Zilin Yu, Zhigang Sun, Fei Yu, Xiaoyan Gong, Hongbo Feng, Jing Lu, Yanjun Zhang
OBJECTIVES: Pancreatic islet amyloid deposition occurs before β-cell damage in type 2 diabetes mellitus patients. The islet and Alzheimer's disease β-amyloid shares similar secondary structures. The Alzheimer's disease β-amyloid targeting tracer [F]FDDNP could be used to image pancreatic islet amyloid with PET. PATIENTS AND METHODS: Consecutive pancreatic tissue sections from a 69-year-old male type 2 diabetes mellitus patient were stained by hematoxylin and eosin, anti-amylin antibody, Congo Red, periodic acid-Schiff, and [F]FDDNP reference compound, respectively...
May 5, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29734258/red-cell-distribution-width-predicts-90-day-mortality-in-continuous-flow-left-ventricular-assist-device-patients
#13
Lauren K Truby, Lakshmi Sridharan, Raul J Flores, A Reshad Garan, Douglas Jennings, Melana Yuzefpolskaya, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Paolo C Colombo, Veli K Topkara
Red cell distribution width (RDW) measures the variance in size of circulating red blood cells and is a strong independent predictor of morbidity and mortality in cardiovascular disease and heart failure. Predictive power of RDW on mortality after continuous-flow left ventricular assist device (CF-LVAD) implantation remains largely unknown. Four hundred nine patients who underwent CF-LVAD implantation between April 2004 and December 2015 were retrospectively analyzed. The primary outcome of interest was 90 day mortality after CF-LVAD implantation...
April 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29733578/erythrocyte-membrane-modified-janus-polymeric-motors-for-thrombus-therapy
#14
Jingxin Shao, Mona Abdelghani, Guizhi Shen, Shoupeng Cao, David S Williams, Jan C M van Hest
We report the construction of erythrocyte membrane-cloaked Janus polymeric motors (EM-JPMs) which are propelled by near infrared laser (NIR) irradiation, and which are successfully applied in thrombus ablation. Chitosan (a natural polysaccharide with positive charge, CHI) and heparin (glycosaminoglycan with negative charge, Hep) were selected as wall materials to construct biodegradable and biocompatible capsules through the layer-by-layer (LbL) self-assembly technique. By partially coating the capsule with a gold (Au) layer through sputter coating, a NIR-responsive Janus structure was obtained...
May 7, 2018: ACS Nano
https://www.readbyqxmd.com/read/29729414/semi-mechanistic-pharmacokinetic-pharmacodynamic-model-of-three-pegylated-rhuepo-and-ior%C3%A2-epocim-in-new-zealand-rabbits
#15
G Reynaldo-Fernández, J Solozábal, D Amaro, E M Fernández-Sánchez, L Rodríguez-Vera, M Bermejo, V Mangas-Sanjuan, I F Troconiz
Marketed formulations of erythropoietin (EPO) ior®EPOCIM, MIRCERA® and two newly developed pegylated-EPO analogues (PEG-EPO 32 and 40 kDa) formulations were intravenously administered to New Zealand rabbits. A semi-mechanistic Pharmacokinetic/Pharmacodynamic (PK/PD) model describing in a simultaneous and integrated form the time course of reticulocytes, red blood cells and hemoglobin was built to account for the time course of hematopoiesis stimulation after erythropoietin administration. Data analysis was performed based on the population approach with the software NONMEM version 7...
May 2, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29716254/estimation-of-polydispersity-in-aggregating-red-blood-cells-by-quantitative-ultrasound-backscatter-analysis
#16
Romain de Monchy, Julien Rouyer, François Destrempes, Boris Chayer, Guy Cloutier, Emilie Franceschini
Quantitative ultrasound techniques based on the backscatter coefficient (BSC) have been commonly used to characterize red blood cell (RBC) aggregation. Specifically, a scattering model is fitted to measured BSC and estimated parameters can provide a meaningful description of the RBC aggregates' structure (i.e., aggregate size and compactness). In most cases, scattering models assumed monodisperse RBC aggregates. This study proposes the Effective Medium Theory combined with the polydisperse Structure Factor Model (EMTSFM) to incorporate the polydispersity of aggregate size...
April 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29714446/association-between-elevated-red-blood-cell-distribution-width-and-long-term-mortality-in-acute-pulmonary-embolism
#17
Shahrbanoo Kheirkham-Sabetghadam, Yaser Jenab, Seyed-Mohammad Ghoreyshi-Hefzabad, Keyvan Gohari-Moghadam, Masoumeh Lotfi-Tokaldany, Arash Jalali, Marzieh Pourjafari, Shapour Shirani, Maryam Sotoudeh Anvari, Nasrin Etesamifar
Background/aim: The prognostic value of the red cell distribution width (RDW) as a cost-effective and noninvasive test in acute pulmonary embolism (PE) is still unknown. We aimed to investigate the prognostic value of the admission RDW level in the long-term survival of PE patients. Materials and methods: In this registry-based, prospective cohort study, a total of 378 patients (mean age: 60.4 ± 17.11 years, 47.4% female) who presented with acute PE were enrolled. All the clinical data for each patient were obtained from our institutional PE registry...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713244/prognostic-role-of-rdw-in-hematological-malignancies-a-systematic-review-and-meta-analysis
#18
Lisha Ai, Shidai Mu, Yu Hu
Background: Red blood cell distribution width (RDW), a biomarker for discrimination of anemia, has been recently identified as a prognostic factor in various types of cancer. Here we performed a meta-analysis in order to assess the correlation between RDW and the survival outcomes in patients with hematologic malignances. Patients/methods: We systematically searched PubMed, Embase, and ISI Web of Science for relevant studies, to investigate the prognostic significance of RDW in hematological malignancies...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29699878/the-role-of-red-cell-distribution-width-in-the-locoregional-recurrence-of-laryngeal-cancer
#19
Gülpembe Bozkurt, Arzu Yasemin Korkut, Pınar Soytaş, Senem Kurt Dizdar, Zeynep Nur Erol
INTRODUCTION: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. OBJECTIVE: We aimed to explore whether the pretreatment red cell distribution width predicted recurrence in laryngeal cancer patients is a simple, reproducible, and inexpensive prognostic biomarker. METHODS: All laryngeal cancer patients who underwent curative surgery (n=132) over a 7 year study period were evaluated...
April 13, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29697933/comparison-of-inflammatory-markers-between-brucella-and-non-brucella-epididymo-orchitis
#20
Ali Cift, Mehmet Ozgur Yucel
OBJECTIVES: Brucellosis is a multi-system infectious disease that is associated with inflammation, which causes an increase in acute phase reactants. Hematological inflammatory markers of brucellosis include mean platelet volume (MPV), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). In this study, we aimed to evaluate the diagnostic value of hematological inflammatory markers in Brucella epididymo-orchitis (BEO), and to investigate the utility of these markers for differential diagnosis from non-Brucella epididymo-orchitis (non-BEO)...
April 15, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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