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Side effect of progesterone

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https://www.readbyqxmd.com/read/27919975/long-term-high-quality-survival-with-single-agent-mifepristone-treatment-despite-advanced-cancer
#1
Jerome H Check, Diane Check, Carrie Wilson, Patrice Lofberg
CASE REPORT: We show long-term high-quality survival following single-agent treatment with a progesterone receptor antagonist in two cases of advanced metastatic cancer. Because no biopsy was performed (patient refused) the exact type of lung cancer was not determined but the majority of oncologists who evaluated the patient thought that the rapid onset and syndrome of inappropriate anti-diuretic hormone was more consistent with small-cell lung cancer. The US Food and Drug Association granted a compassionate-use investigational new drug approval for use of single-agent 200 mg mifepristone orally/day to a moribund woman with never-treated metastatic lung cancer and a male with bilateral renal cell carcinoma who had undergone only a unilateral hemi-nephrectomy...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27894940/changes-in-the-mrna-expression-of-structural-proteins-hormone-synthesis-and-secretion-from-bovine-placentome-sections-after-ddt-and-dde-treatment
#2
A Wojciechowska, J Mlynarczuk, J Kotwica
Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metabolite 1,1-dichloro-2,2-bis-4-chlorophenyl-ethene (DDE) (for 24 or 48h) at doses of 1, 10 or 100ng/ml on the function of cow placentome sections in the second trimester of pregnancy. DDT and DDE affected neither (P>0...
November 25, 2016: Toxicology
https://www.readbyqxmd.com/read/27890531/short-term-effects-of-diabetes-on-neurosteroidogenesis-in-the-rat-hippocampus
#3
Simone Romano, Nico Mitro, Silvia Diviccaro, Roberto Spezzano, Matteo Audano, Luis Miguel Garcia-Segura, Donatella Caruso, Roberto Cosimo Melcangi
Diabetes may induce neurophysiological and structural changes in the central nervous system (i.e., diabetic encephalopathy). We here explored whether the levels of neuroactive steroids (i.e., neuroprotective agents) in the hippocampus may be altered by short-term diabetes (i.e., one month). To this aim, by liquid chromatography-tandem mass spectrometry we observed that in the experimental model of the rat raised diabetic by streptozotocin injection, one month of pathology induced changes in the levels of several neuroactive steroids, such as pregnenolone, progesterone and its metabolites (i...
November 23, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27852187/prevention-of-breast-cancer
#4
Ian N Olver
Modifiable lifestyle factors may reduce the risk of developing breast cancer. Obesity is associated particularly with post-menopausal breast cancer. Diet is important, and exercise equivalent to running for up to 8 hours each week reduces the risk of breast cancer, both in its own right and through reducing obesity. Alcohol consumption may be responsible for 5.8% of breast cancers in Australia and it is recommended to reduce this to two standard drinks per day. Drinking alcohol and smoking increases the risk for breast cancer and, therefore, it is important to quit tobacco smoking...
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27746881/gastric-metastasis-of-breast-cancer-a-case-series
#5
Gustavo Dos Santos Fernandes, Luiza D Batista Bugiato Faria, Isadora de Assis Pereira, Natália C Moreira Neves, Yasmine Oliveira Vieira, Alessandro I Cavalcanti Leal
Gastric metastasis is rare but it can be the initial symptom of cancer. The second leading cause of this type of metastasis is breast cancer. A lack of clinical signs and nonspecific side effects of the treatment of primary tumors can lead to the misdiagnosis of metastatic gastric cancer. Upper gastrointestinal endoscopy with biopsy and immunohistochemistry should be used for diagnosis. Treatment is palliative; it includes chemo, endocrine, and radiation therapies. Four patients with breast cancer and gastric metastasis were identified...
September 5, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27744092/subcortical-gray-matter-changes-in-transgender-subjects-after-long-term-cross-sex-hormone-administration
#6
Rene Seiger, Andreas Hahn, Allan Hummer, Georg S Kranz, Sebastian Ganger, Michael Woletz, Christoph Kraus, Ronald Sladky, Alexander Kautzky, Siegfried Kasper, Christian Windischberger, Rupert Lanzenberger
Sex-steroid hormones are primarily involved in sexual differentiation and development and are thought to underlie processes related to cognition and emotion. However, divergent results have been reported concerning the effects of hormone administration on brain structure including side effects like brain atrophy and dementia. Cross-sex hormone therapy in transgender subjects offers a unique model for studying the effects of sex hormones on the living human brain. In this study, 25 Female-to-Male (FtM) and 14 Male-to-Female (MtF) subjects underwent MRI examinations at baseline and after a period of at least 4-months of continuous cross-sex hormone administration...
October 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27678094/genomic-and-nongenomic-effects-of-mifepristone-at-the-cardiovascular-level-a-review
#7
Joana Feiteiro, Melissa Mariana, Ignacio Verde, Elisa Cairrão
Mifepristone (RU 486) is a compound that is structurally related to steroid hormones, which is derived from the estrane progestins. This compound strongly binds the progesterone and glucocorticoid receptor and, to a lesser extent, the androgen receptor. This compound has its effects through different signaling pathways, related to genomic and nongenomic effects. The genomic effect involves the activation or blockage of nuclear or intracellular receptor, that in this case the progesterone, glucocorticoid, and androgen receptors...
September 27, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27658744/parturition-induction-in-ewes-by-a-progesterone-receptor-blocker-aglepristone-and-subsequent-neonatal-survival-preliminary-results
#8
R G Özalp, A Yavuz, A Orman, I Seker, D Udum Küçükşen, A Rişvanlı, Ö O Demiral, A Wehrend
The clinical effects of aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition...
August 22, 2016: Theriogenology
https://www.readbyqxmd.com/read/27642297/myoinositol-as-a-safe-and-alternative-approach-in-the-treatment-of-infertile-pcos-women-a-german-observational-study
#9
Pedro-Antonio Regidor, Adolf Eduard Schindler
The use of 2 × 2000 mg myoinositol + 2 × 200 μg folic acid per day is a safe and promising tool in the effective improvement of symptoms and infertility for patients with a polycystic ovary syndrome (PCOS). Using a questionnaire an observational study was performed under German gynecologists to collect data on ovulation and pregnancy rates in PCOS patients with infertility. In this observational study, 3602 infertile women used myoinositol and folic acid between 2 and 3 months in a dosage of 2 × 2000 mg myoinositol + 2 × 200 μg folic acid per day...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27597394/progesterone-treatment-modulates-mrna-of-neurosteroidogenic-enzymes-in-a-murine-model-of-multiple-sclerosis
#10
Laura Garay, Paula Gonzalez Giqueaux, Rachida Guennoun, Michael Schumacher, Maria Claudia Gonzalez Deniselle, Alejandro F De Nicola
Previous studies of experimental autoimmune encephalomyelitis (EAE) have shown that progesterone decreases inflammatory cell infiltration and proinflammatory factors, increases myelination and attenuates clinical grade of EAE mice. To elucidate potential mediators of these effects, we analyzed the mRNA expression of neurosteroidogenic enzymes in the spinal cord, in view of the protective role of steroids in EAE. We also analyzed mitochondrial morphology and dynamics (fusion and fission proteins), considering the role of mitochondria in neurosteroidogenesis...
January 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27548404/progestogen-safety-and-tolerance-in-hormonal-replacement-therapy
#11
Santiago Palacios, Andrea Mejía
Today, it is a mandatory practice to prescribe a combination of estrogens and progestogens for menopausal women requiring hormone therapy and with a uterus. The WHI study and its reanalysis demonstrate a big difference in results between the conjugated equin estrogen (CEE) only vs.CEE plus medroxyprogesterone acetate (MPA) arms in relation with breast cancer and cardiovascular risk. The conclusion is that risk is clearly higher in the arm with MPA than in the CEE only arm. Although the only progestogen used in the WHI study was medroxyprogesterone acetate, side effects and intolerance have been extrapolated as a class effect to all progestogens...
November 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27512005/effect-of-adiponectin-on-the-steroidogenic-acute-regulatory-protein-p450-side-chain-cleavage-enzyme-and-3%C3%AE-hydroxysteroid-dehydrogenase-gene-expression-progesterone-and-androstenedione-production-by-the-porcine-uterus-during-early-pregnancy
#12
N Smolinska, K Dobrzyn, M Kiezun, K Szeszko, A Maleszka, T Kaminski
Adiponectin and its receptors are expressed in the human and porcine uterus and this endocrine system has important role in the regulation of reproductive processes. The expression of steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (HSD3B1) were observed in the human and porcine uterus during the oestrous cycle and pregnancy. The de novo synthesis of steroids in the uterus might be a crucial factor for effective implantation and maintenance of pregnancy. We hypothesized that adiponectin modulates the expression of key enzymes in the synthesis of the steroids: StAR, P450 side chain cleavage enzyme (CYP11A1) and HSD3B1, as well as progesterone (P4) and androstenedione (A4) secretion by the porcine uterus...
June 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27503693/hormonal-therapy-for-endometriosis-from-molecular-research-to-bedside
#13
Claudia Tosti, Antonella Biscione, Giuseppe Morgante, Giuseppe Bifulco, Stefano Luisi, Felice Petraglia
Endometriotic lesions are associated with hormonal imbalance, including increased estrogen synthesis, metabolism and progesterone resistance. These hormonal changes cause increased proliferation, inflammation, pain and infertility. Hormonal imbalances are targets for treatment. Therapeutic strategies and innovations of hormonal drugs for endometriosis are increasing. Acting on estrogen receptors are hormonal drugs decreasing systemic and local estrogen synthesis (GnRH analogs, GnRH antagonists, Aromatase inhibitors) or estrogen activity (selective estrogen receptor modulators)...
May 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27503318/hcg-mediated-activation-of-mtorc1-signaling-plays-a-crucial-role-in-steroidogenesis-in-human-granulosa-lutein-cells
#14
Molly B Moravek, Min Shang, Bindu Menon, K M J Menon
Luteinizing hormone/human chorionic gonadotropin stimulates progesterone biosynthesis in the corpus luteum by activating cyclic adenosine monophosphate/protein kinase A cascade. Recent studies have shown that cyclic adenosine monophosphate-mediated activation of protein kinase A interacts with the mammalian target of rapamycin signaling pathways. Furthermore, the use of mammalian target of rapamycin inhibitors for immunosuppression in transplant patients has shown adverse effects in reproductive functions. This study examined whether the mammalian target of rapamycin pathway plays any role in luteinizing hormone-mediated regulation of progesterone production...
October 2016: Endocrine
https://www.readbyqxmd.com/read/27500900/endometrial-breakdown-with-sustained-progesterone-release-involves-nf-%C3%AE%C2%BAb-mediated-functional-progesterone-withdrawal-in-a-mouse-implant-model
#15
Guo-Hong Zhang, Li-Jing Cui, Ai-Ying Li, Jian-Ping Zhang, Yu Liu, Jing-Shan Zhao, Xiang-Bo Xu, Bin He, Jie-Dong Wang, Li Chu, Yun-Feng Li
Irregular uterine bleeding is a major side effect of long-acting progestogen-only contraceptives in women, and is the primary reason women discontinue their use. In this study, a mouse model of endometrial breakdown was established using a subcutaneous progesterone implant to understand how irregular bleeding begins. Although progestogens sustained decidualization, endometrial breakdown was still observed in this model. We, therefore, hypothesized that endometrial breakdown might involve functional progesterone withdrawal...
September 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27426448/cytochrome-b5-activates-the-17-20-lyase-activity-of-human-cytochrome-p450-17a1-by-increasing-the-coupling-of-nadph-consumption-to-androgen-production
#16
Hwei-Ming Peng, Sang-Choul Im, Naw May Pearl, Adina F Turcu, Juilee Rege, Lucy Waskell, Richard J Auchus
Human cytochrome P450 17A1 is required for all androgen biosynthesis and is the target of abiraterone, a drug used widely to treat advanced prostate cancer. P450 17A1 catalyzes both 17-hydroxylation and subsequent 17,20-lyase reactions with pregnenolone, progesterone, and allopregnanolone. The presence of cytochrome b5 (b5) markedly stimulates the 17,20-lyase reaction, with little effect on 17-hydroxylation; however, the mechanism of this b5 effect is not known. We determined the influence of b5 on coupling efficiency-defined as the ratio of product formation to NADPH consumption-in a reconstituted system using these 3 pairs of substrates for the 2 reactions...
August 9, 2016: Biochemistry
https://www.readbyqxmd.com/read/27421178/transient-inactivation-of-the-nucleus-accumbens-nac-shell-prominently-ameliorates-responses-to-acute-stress-in-female-rats
#17
Tahereh-Sadat Javadifar, Hedayat Sahraei, Mohammad-Ali Ketabi, Mohammad Nasehi, Mohammad-Reza Zarrindast
It is clear that the stress response differs between females and males. Moreover, the nucleus accumbens shell is considered a critical area in the brain's response to stress. In the present study we investigate the effect of the transient inactivation of the NAc shell on the metabolic and hormonal disturbance induced by acute stress in female rats. Female Wistar rats were canulated uni- or bilaterally in the NAc shell before stress induction. Electric foot shock was applied to the animals and lidocaine hydrochloride was administered intra-acumbally 5min before each stress session...
July 12, 2016: Brain Research
https://www.readbyqxmd.com/read/27405353/effectiveness-of-a-cervical-pessary-for-women-who-did-not-deliver-48%C3%A2-h-after-threatened-preterm-labor-assessment-of-perinatal-outcome-after-specific-treatment-in-early-labor-apostel-vi-trial
#18
Frederik J R Hermans, Ewoud Schuit, Brent C Opmeer, Martijn A Oudijk, Mireille Bekker, Mallory Woiski, Caroline J Bax, Marieke Sueters, Hubertina C J Scheepers, Maureen T M Franssen, Eva Pajkrt, Ben Willem J Mol, Marjolein Kok
BACKGROUND: Preterm birth is a major cause of neonatal mortality and morbidity. As preventive strategies are largely ineffective, threatened preterm labor is a frequent problem that affects approximately 10 % of pregnancies. In recent years, risk assessment in these women has incorporated cervical length measurement and fetal fibronectin testing, and this has improved the capacity to identify women at increased risk for delivery within 14 days. Despite these improvements, risk for preterm birth continues to be increased in women who did not deliver after an episode of threatened preterm labor, as indicated by a preterm birth rate between 30 to 60 % in this group of women...
2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27402506/metformin-targeting-autophagy-overcomes-progesterone-resistance-in-endometrial-carcinoma
#19
Zhihong Zhuo, Aiming Wang, Huimin Yu
PURPOSE: Metformin is the most prescribed anti-diabetic medication worldwide because of its proven efficacy and limited side effects. In this study, the significant anticancer effect of metformin was investigated in both endometrial carcinoma and progesterone-resistant endometrial carcinoma cells. METHODS: We tested the growth inhibition assay using MTT cell proliferation, cell cycle assay, apoptosis assessment with flow cytometry using propidium iodide and Annexin V, and autophagy protein expression with western blot analysis...
July 11, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27397976/plasma-progesterone-profile-and-conception-rate-following-exogenous-supplementation-of-gonadotropin-releasing-hormone-human-chorionic-gonadotropin-and-progesterone-releasing-intra-vaginal-device-in-repeat-breeder-crossbred-cows
#20
N K J Pandey, H P Gupta, Shiv Prasad, S K Sheetal
AIM: This study was designed to evaluate the effect of gonadotropin-releasing hormone (GnRH), human chorionic gonadotropin (hCG), and progesterone impregnated intra-vaginal device on progesterone profile and conception rate in repeat-breeding crossbred cows. MATERIALS AND METHODS: Repeat-breeding crossbred cows aged 3-8 years (n=32), lactating and negative to white side test were randomly divided into four groups: Group 1 (Control, n=8), Group 2 (GnRH at 10 µg i...
June 2016: Veterinary World
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