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Side effect of progesterone

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https://www.readbyqxmd.com/read/29768979/mesoporous-silica-nanoparticle-is-comparatively-safer-than-zinc-oxide-nanoparticle-which-can-cause-profound-steroidogenic-effects-on-pregnant-mice-and-male-offspring-exposed-in-utero
#1
Nisha Bara, M Eshwarmoorthy, Kesavan Subaharan, Gautam Kaul
The increasing use of nanomaterials has naturally caused heightened concerns about their potential risks to human and animal health. We investigated the effect of zinc oxide nanoparticles (ZnO NPs) and mesoporous silica nanoparticles (MSN) on steroidogenesis in the corpus luteum (CL) of pregnant mice and testis of male offspring. Pregnant albino mice were exposed to ZnO NPs and MSN for 2 days on alternate days, gestation days 15-19. Hepatic injury marker enzymes increased in the higher concentration of NM-exposed mother mice, but histological examination revealed no changes in the placenta of pregnant mice, whereas testis of male offspring showed gross pathological changes...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29742817/effects-of-thyroid-dysfunction-on-reproductive-hormones-in-female-rats
#2
Juan Liu, Meng Guo, Xusong Hu, Xuechun Weng, Ye Tian, Kaili Xu, Dai Heng, Wenbo Liu, Yu Ding, Yanzhou Yang, Cheng Zhang
Thyroid hormones (THs) play a critical role in the development of ovarian cells. Although the effects of THs on female reproduction are of great interest, the mechanism remains unclear. We investigated the effects of TH dysregulation on reproductive hormones in rats. Propylthiouracil (PTU) and L-thyroxine were administered to rats to induce hypo- and hyper-thyroidism, respectively, and the reproductive hormone profiles were analyzed by radioimmunoassay. Ovarian histology was evaluated with H&E staining, and gene protein level or mRNA content was analyzed by western blotting or RT-PCR...
May 10, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29723408/a-novel-cross-species-inhibitor-to-study-the-function-of-catsper-ca-2-channels-in-sperm
#3
Andreas Rennhack, Christian Schiffer, Christoph Brenker, Dmitry Fridman, Elis T Nitao, Yi-Min Cheng, Lara Tamburrino, Melanie Balbach, Gabriel Stölting, Thomas K Berger, Michelina Kierzek, Luis Alvarez, Dagmar Wachten, Xu-Hui Zeng, Elisabetta Baldi, Stephen Publicover, U Benjamin Kaupp, Timo Strünker
BACKGROUND AND PURPOSE: Sperm from many species share the sperm-specific Ca2+ channel CatSper (cation channel of sperm) that controls the intracellular Ca2+ concentration and, thereby, the swimming behaviour. A growing body of evidence suggests that the mechanisms controlling CatSper activity and the role of the channel during fertilization differ among species. However, a lack of suitable pharmacological tools has hampered the elucidation of the function of CatSper. Known CatSper inhibitors exhibit considerable side effects and inhibit also Slo3, the K+ channel in mammalian sperm...
May 3, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29721586/corticosteroid-binding-globulin-induced-in-testicular-leydig-cells-by-perfluorooctanoic-acid-promotes-steroid-hormone-synthesis
#4
Sujie Sun, Jianshe Wang, Yin Lu, Jiayin Dai
Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. It is a ubiquitous environmental pollutant and suspected endocrine disruptor. Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Our previous proteomic profile analysis revealed that CBG levels increased in testes after PFOA treatment. In the present study, we verified its increase in mouse testes following oral exposure to PFOA (0, 1...
May 2, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29713164/global-trends-in-nanomedicine-research-on-triple-negative-breast-cancer-a-bibliometric-analysis
#5
REVIEW
Ramon Handerson Gomes Teles, Herick Fernando Moralles, Márcia Regina Cominetti
Nanotechnology has emerged as a promising tool in the clinic to combat several difficult-to-manage diseases, such as cancer, which is the second leading cause of death worldwide. Chemotherapeutic drugs present several limitations such as undesired side effects, low specificity, resistance, and high relapse rates. Triple negative breast cancer (TNBC) is caused by cells that lack specific receptors in their membrane, such as estrogen (ER+) and progesterone (PR+) receptors, or by cells that do not express the amplification of human epidermal growth factor receptor-2 (HER-2+)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29662964/comparison-of-the-effects-of-ginger-extract-with-clomiphene-citrate-on-sex-hormones-in-rats-with-polycystic-ovarian-syndrome
#6
Shekoufeh Atashpour, Hossein Kargar Jahromi, Zahra Kargar Jahromi, Mozhgan Maleknasab
Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women which affect fertility. Clomiphene citrate is used as first-line treatment for this disorder, which is associated with some complications and therapeutic resistance. Objective: In this research, we compare the effectiveness of ginger with clomiphene on sexual hormones such as Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), estrogen and progesterone in order to treat PCOS effectively with fewer side effects...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29615065/efficacy-safety-and-recurrence-of-new-progestins-and-selective-progesterone-receptor-modulator-for-the-treatment-of-endometriosis-a-comparison-study-in-mice
#7
Bo Liang, Ling Wu, Hui Xu, Chun Wai Cheung, Wen Ying Fung, Sze Wai Wong, Chi Chiu Wang
BACKGROUND: Current medical treatments for endometriosis are very limited. Progestin and selective progesterone receptor modulators (SPRM) are developed but their efficacy, safety, mechanism and recurrence in endometriosis are not fully studied. METHODS: In order to compare therapeutic, side effects and therapeutic actions of Esmya, Duphaston and Dienogest in endometriosis. Experimental endometriosis was induced by either intraperitoneal or subcutaneous mouse endometrium transplantation...
April 3, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29583019/vaginal-progesterone-and-the-vaginal-first-pass-effect
#8
M P Warren
Vaginal progesterone is an effective alternative to systemic administration by oral or intramuscular use. The first-pass effect is reviewed, as are the most common uses for this route of delivery. This includes use in hormone replacement therapy, luteal support particularly in assisted reproduction, and avoidance of side-effects of oral progestins and progesterone. Vaginal progesterone represents a unique therapeutic solution to a number of clinical problems.
March 27, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29556248/growth-of-triple-negative-and-progesterone-positive-breast-cancer-causes-oxidative-stress-and-down-regulates-neuroprotective-transcription-factor-npas4-and-npas4-regulated-genes-in-hippocampal-tissues-of-tumorgraft-mice-an-aging-connection
#9
Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Amanda Katz, David Sidransky, Bryan Kolb, Olga Kovalchuk
While the refinement of existing and the development of new chemotherapeutic regimens has significantly improved cancer treatment outcomes and patient survival, chemotherapy still causes many persistent side effects. Central nervous system (CNS) toxicity is of particular concern, as cancer patients experience significant deficits in memory, learning, cognition, and decision-making. These chemotherapy-induced cognitive changes are termed chemo brain, and manifest in more than half of cancer survivors. Moreover, recent studies have emerged suggesting that neurocognitive deficits manifest prior to cancer diagnosis and treatment, and thus may be associated with tumor presence, a phenomenon recently termed "tumor brain...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29526019/systematic-versus-sentinel-lymph-node-driven-axillary-lymph-node-dissection-in-clinically-node-negative-patients-with-operable-breast-cancer-results-of-the-gf-gs01-randomized-trial
#10
P Roy, A Leizorovicz, R Villet, C Mercier, J Y Bobin
PURPOSE: Sentinel-lymph-node (SLN) resection seems to minimize systematic axillary-lymph-node dissection (sALND) side effects in operated breast cancer patients. We explored whether SLN resection achieves similar therapeutic outcomes as sALND but with fewer side effects. METHODS: A randomized, controlled, open-label trial with parallel-group design compared sALND restricted to cases with positive SLN biopsy (test arm, n = 774) versus SLN biopsy followed by sALND (control arm, n = 770)...
March 10, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29498933/management-of-women-with-pcos-using-myo-inositol-and-folic-acid-new-clinical-data-and-review-of-the-literature
#11
Pedro-Antonio Regidor, Adolf Eduard Schindler, Bernd Lesoine, Rene Druckman
Introduction The use of 2 × 2000 mg myo-inositol +2 × 200 μg folic acid per day is a safe and promising tool in the effective improvement of symptoms and infertility for patients with polycystic ovary syndrome (PCOS). In addition, PCOS is one of the pathological factors involved in the failure of in vitro fertilization (IVF). Typically, PCOS patients suffer of poor quality oocytes. Patients and methods In an open, prospective, non-blinded, non-comparative observational study, 3602 infertile women used myo-inositol and folic acid between 2 and 3 months in a dosage of 2 × 2000 mg myo-inositol +2 × 200 μg folic acid per day...
March 2, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29488367/oral-dydrogesterone-vs-vaginal-progesterone-capsules-for-luteal-phase-support-in-women-undergoing-embryo-transfer-a-systematic-review-and-meta-analysis
#12
Marina Wanderley Paes Barbosa, Natália Paes Barbosa Valadares, Antônio César Paes Barbosa, Adelino Silva Amaral, José Rubens Iglesias, Carolina Oliveira Nastri, Wellington de Paula Martins, Hitomi Miura Nakagawa
OBJECTIVE: To identify, appraise, and summarize the evidence from randomized controlled trials (RCTs) comparing oral dydrogesterone to vaginal progesterone capsules for luteal-phase support (LPS) in women offered fresh or frozen embryo transfers following in vitro fertilization. METHODS: Two independent authors screened the literature for papers based on titles and abstracts, then selected the studies, extracted data, and assessed the risk of bias. Dydrogesterone and progesterone were compared based on risk ratios (RR) and the precision of the estimates was assessed through the 95% confidence interval (CI)...
February 28, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29482983/adjuvant-anastrozole-versus-exemestane-versus-letrozole-upfront-or-after-2-years-of-tamoxifen-in-endocrine-sensitive-breast-cancer-fata-gim3-a-randomised-phase-3-trial
#13
Sabino De Placido, Ciro Gallo, Michelino De Laurentiis, Giancarlo Bisagni, Grazia Arpino, Maria Giuseppa Sarobba, Ferdinando Riccardi, Antonio Russo, Lucia Del Mastro, Alessio Aligi Cogoni, Francesco Cognetti, Stefania Gori, Jennifer Foglietta, Antonio Frassoldati, Domenico Amoroso, Lucio Laudadio, Luca Moscetti, Filippo Montemurro, Claudio Verusio, Antonio Bernardo, Vito Lorusso, Adriano Gravina, Gabriella Moretti, Rossella Lauria, Antonella Lai, Carmela Mocerino, Sergio Rizzo, Francesco Nuzzo, Paolo Carlini, Francesco Perrone
BACKGROUND: Uncertainty exists about the optimal schedule of adjuvant treatment of breast cancer with aromatase inhibitors and, to our knowledge, no trial has directly compared the three aromatase inhibitors anastrozole, exemestane, and letrozole. We investigated the schedule and type of aromatase inhibitors to be used as adjuvant treatment for hormone receptor-positive early breast cancer. METHODS: FATA-GIM3 is a multicentre, open-label, randomised, phase 3 trial of six different treatments in postmenopausal women with hormone receptor-positive early breast cancer...
April 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29458401/efficacy-and-safety-of-ding-kun-dan-for-female-infertility-patients-with-predicted-poor-ovarian-response-undergoing-in-vitro-fertilization-intracytoplasmic-sperm-injection-study-protocol-for-a-randomized-controlled-trial
#14
Saihua Ma, Ruihong Ma, Tian Xia, Masoud Afnan, Xueru Song, Fengqin Xu, Guimin Hao, Fangfang Zhu, Jingpei Han, Zhimei Zhao
BACKGROUND: Women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) who have a predicted poor ovarian response (POR) present a challenge for reproductive medicine specialists. Traditional Chinese medicine (TCM) is commonly used in China for such patients, in the belief that it will improve the ovarian response and ultimately increase pregnancy rates. However, there is a lack of high-quality evidence about the effect of TCM on improving ovarian response in such patients...
February 20, 2018: Trials
https://www.readbyqxmd.com/read/29345445/the-impact-of-high-progesterone-levels-on-the-day-of-hcg-administration-in-assisted-human-reproduction-treatments
#15
Michelli S Tanada, Ivan H Yoshida, Monise Santos, Caroline Z Berton, Elen Souto, Waldemar P de Carvalho, Emerson B Cordts, Caio P Barbosa
OBJECTIVE: Progesterone is a steroid hormone that acts on the endometrium. It is known for producing physical and mood-related side effects. Few studies have looked into how progesterone levels affect embryo development and quality. This study aimed to find a cutoff level for serum progesterone on the day of HCG administration from which embryo quality is impaired. METHODS: The study included 145 cycles, from which 885 oocytes and 613 embryos were obtained. All patients had their serum progesterone levels measured on the day of HCG administration...
January 18, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29315431/receptor-conversion-in-distant-breast-cancer-metastases-a-systematic-review-and-meta-analysis
#16
Willemijne A M E Schrijver, Karijn P M Suijkerbuijk, Carla H van Gils, Elsken van der Wall, Cathy B Moelans, Paul J van Diest
Background: In metastatic breast cancer, hormone and/or human epidermal growth factor receptor 2 (HER2)-targeted therapy decision-making is still largely based on tissue characteristics of the primary tumor. However, a change of estrogen receptor alpha (ERα), progesterone receptor (PR), and HER2 status in distant metastases has frequently been reported. The actual incidence of this phenomenon has been debated. Methods: We performed a meta-analysis including 39 studies assessing receptor conversion from primary breast tumors to paired distant breast cancer metastases...
January 5, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29303051/a-novel-function-of-geranylgeraniol-in-regulating-testosterone-production
#17
Hsin-Jung Ho, Hitoshi Shirakawa, Puspo E Giriwono, Asagi Ito, Michio Komai
Isoprenoids play widely differing roles in various physiological processes in animals and plants. Geranylgeraniol (GGOH) is an isoprenoid found in plants, and is an important metabolic derivative in the isoprenoid/cholesterol synthesis pathway. Earlier studies focused on GGOH's ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway. More recently, the mevalonate pathway-independent effects of GGOH have been described, including anti-inflammatory, anti-tumorigenic, and neuroprotective activities...
January 5, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29277070/melatonin-stimulates-the-secretion-of-progesterone-along-with-the-expression-of-cholesterol-side-chain-cleavage-enzyme-p450scc-and-steroidogenic-acute-regulatory-protein-star-in-corpus-luteum-of-pregnant-sows
#18
Wenlong Zhang, Zhenyu Wang, Liang Zhang, Zelin Zhang, Jinxuan Chen, Weicong Chen, Dewen Tong
The direct effect of melatonin on porcine luteal function during the pregnancy remains unknown. The objective of the study was to analyse the molecular mechanism(s) by which melatonin directly affects progesterone (P4) production in the corpus luteum (CL) of pregnant sows. We evaluated the localization of melatonin membrane receptors (MT1 and MT2) in CL, and investigated the effect of melatonin on P4 secretion along with the expression of P4 synthesis intermediates in luteal cells. Immunohistochemistry analysis showed that MT1 and MT2 were predominantly localized in luteal cells in pregnant luteal tissues...
March 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/29260904/ulipristal-acetate-for-the-management-of-acute-heavy-menstrual-bleeding-without-fibroids
#19
Josep Estadella, Pia Español, Fiorella Ascencio, Josep Perelló, Joaquim Calaf
Heavy menstrual bleeding is a common condition among women of childbearing age. Although hysterectomy was the usual approach in acute cases in the past, other minimally invasive therapies or pharmacological alternatives, such as the levonorgestrel intrauterine device have shown to be highly effective. This case report presents the case of a pluripathological patient with acute heavy menstrual bleeding and severe anemia, who was successfully managed with ulipristal acetate, a selective progesterone receptor modulator...
December 20, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29179434/growth-of-malignant-extracranial-tumors-alters-micrornaome-in-the-prefrontal-cortex-of-tumorgraft-mice
#20
Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Amanda Katz, David Sidransky, Bryan Kolb, Olga Kovalchuk
A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it affects over half of cancer survivors. Recent studies reported that cognitive impairments manifest before chemotherapy and are much broader than chemo brain alone, thereby adding in tumor brain as a component. The molecular mechanisms of chemo brain are under-investigated, and the mechanisms of tumor brain have not been analyzed at all...
October 24, 2017: Oncotarget
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