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Proteinuria diabetes

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https://www.readbyqxmd.com/read/28927644/acute-kidney-injury-is-a-risk-factor-for-subsequent-proteinuria
#1
Sharidan K Parr, Michael E Matheny, Khaled Abdel-Kader, Robert A Greevy, Aihua Bian, James Fly, Guanhua Chen, Theodore Speroff, Adriana M Hung, T Alp Ikizler, Edward D Siew
Acute kidney injury (AKI) is associated with subsequent chronic kidney disease (CKD), but the mechanism is unclear. To clarify this, we examined the association of AKI and new-onset or worsening proteinuria during the 12 months following hospitalization in a national retrospective cohort of United States Veterans hospitalized between 2004-2012. Patients with and without AKI were matched using baseline demographics, comorbidities, proteinuria, estimated glomerular filtration rate, blood pressure, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker (ACEI/ARB) use, and inpatient exposures linked to AKI...
September 16, 2017: Kidney International
https://www.readbyqxmd.com/read/28927413/erratum-to-changes-in-proteinuria-and-the-risk-of-myocardial-infarction-in-people-with-diabetes-or-pre-diabetes-a-prospective-cohort-study
#2
Anxin Wang, Yang Sun, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu, Xiuhua Guo
Following publication of the original article [1], the authors reported that figure 2 had not been replaced with the correct figure as indicated in the proofs.
September 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28923913/variations-in-microrna-25-expression-influence-the-severity-of-diabetic-kidney-disease
#3
Yunshuang Liu, Hongzhi Li, Jieting Liu, Pengfei Han, Xuefeng Li, He Bai, Chunlei Zhang, Xuelian Sun, Yanjie Teng, Yufei Zhang, Xiaohuan Yuan, Yanhui Chu, Binghai Zhao
Diabetic nephropathy is characterized by persistent albuminuria, progressive decline in GFR, and secondary hypertension. MicroRNAs are dysregulated in diabetic nephropathy, but identification of the specific microRNAs involved remains incomplete. Here, we show that the peripheral blood from patients with diabetes and the kidneys of animals with type 1 or 2 diabetes have low levels of microRNA-25 (miR-25) compared with those of their nondiabetic counterparts. Furthermore, treatment with high glucose decreased the expression of miR-25 in cultured kidney cells...
September 18, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28918587/genome-wide-association-studies-of-albuminuria-towards-genetic-stratification-in-diabetes
#4
REVIEW
Cristian Pattaro
Genome-wide association studies (GWAS) have been very successful in unraveling the polygenic structure of several complex diseases and traits. In the case of albuminuria, despite the large sample size achieved by some studies, results look sparse with a limited number of loci reported so far. This review searched for GWAS studies of albumin excretion, albuminuria, and proteinuria. The resulting picture sets elements of uniqueness for albuminuria GWAS with respect to other complex traits. So far, very few loci associated with albuminuria have been validated by means of genome-wide significant evidence or formal replication...
September 16, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28912839/addition-of-nonalbumin-proteinuria-to-albuminuria-improves-prediction-of-type-2-diabetic-nephropathy-progression
#5
Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim, In Joo Kim
BACKGROUND: Albuminuria is generally accepted as a sensitive marker of diabetic nephropathy but has limitations in predicting its progression. The aim of this study was to evaluate the use of nonalbumin proteinuria in addition to albuminuria for predicting the progression of type 2 diabetic nephropathy. METHODS: In this retrospective observational study, the urine albumin-to-creatinine ratio (ACR) and the nonalbumin protein-to-creatinine ratio (NAPCR) were measured in 325 patients with type 2 diabetes and estimated glomerular filtration rates (eGFR) ≥30 mL/min/1...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28899432/prevalence-and-associations-of-microalbuminuria-in-proteinuria-negative-patients-with-type-2-diabetes-in-two-regional-hospitals-in-cameroon-a-cross-sectional-study
#6
Nelsy T Efundem, Jules Clement N Assob, Vitalis F Feteh, Simeon-Pierre Choukem
BACKGROUND: Microalbuminuria (MA) is the earliest clinical evidence of diabetic nephropathy, but most patients in sub-Saharan Africa (SSA) only have access to much cheaper dipstick proteinuria as a means to screen for diabetic nephropathy. The aim of this study was to determine the prevalence and associations of MA among proteinuria-negative type 2 diabetic patients in a SSA setting. METHODS: In this cross-sectional study, patients with type 2 diabetes screened negative for dipstick proteinuria in a primary healthcare hospital were assessed...
September 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28894114/cinaciguat-ameliorates-glomerular-damage-by-reducing-erk1-2-activity-and-tgf-%C3%A3-expression-in-type-1-diabetic-rats
#7
Szabina Czirok, Lilla Fang, Tamás Radovits, Gábor Szabó, Gábor Szénási, László Rosivall, Béla Merkely, Gábor Kökény
Decreased soluble guanylate cyclase activity and cGMP levels in diabetic kidneys were shown to influence the progression of nephropathy. The regulatory effects of soluble guanylate cyclase activators on renal signaling pathways are still unknown, we therefore investigated the renal molecular effects of the soluble guanylate cyclase activator cinaciguat in type-1 diabetic (T1DM) rats. Male adult Sprague-Dawley rats were divided into 2 groups after induction of T1DM with 60 mg/kg streptozotocin: DM, untreated (DM, n = 8) and 2) DM + cinaciguat (10 mg/kg per os daily, DM-Cin, n = 8)...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890943/trial-of-amiloride-in-type-2-diabetes-with-proteinuria
#8
Mark L Unruh, V Shane Pankratz, John E Demko, Evan C Ray, Rebecca P Hughey, Thomas R Kleyman
INTRODUCTION: Renal Na(+) retention and extracellular fluid volume expansion are hallmarks of nephrotic syndrome, which occurs even in the absence of activation of hormones that stimulate renal Na(+) transporters. Plasmin-dependent activation of the epithelial Na(+) channel (ENaC) has been proposed to have a role in renal Na(+) retention in the setting of nephrotic syndrome. We hypothesized that the ENaC inhibitor amiloride would be an effective therapeutic agent in inducing a natriuresis and lowering blood pressure in individuals with macroscopic proteinuria...
September 2017: KI Reports
https://www.readbyqxmd.com/read/28885376/clinicopathological-features-of-diabetic-and-nondiabetic-renal-diseases-in-type-2-diabetic-patients-with-nephrotic-range-proteinuria
#9
Yu Ho Lee, Ki-Pyo Kim, Yang Gyun Kim, Ju-Young Moon, Su Woong Jung, Eunji Park, Jin Sug Kim, Kyung-Hwan Jeong, Tae Won Lee, Chun-Gyoo Ihm, Young-Il Jo, Hoon-Young Choi, Hyeong-Cheon Park, So-Young Lee, Dong-Ho Yang, Joo-Hark Yi, Sang-Woong Han, Sang-Ho Lee
Heavy proteinuria with or without features of nephrotic syndrome is associated with many primary and systemic diseases. For diabetic patients, distinguishing nondiabetic renal disease (NDRD) from diabetic nephropathy (DN) is important in choosing treatment modalities and determining renal prognosis. However, clinical relevance of heavy proteinuria is inconsistent with clinical DN assessments. This study investigated the clinicopathological features and renal outcomes of DN and NDRD in type 2 diabetic patients with nephrotic-range proteinuria...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28882857/effect-of-sofosbuvir-based-hepatitis-c-virus-therapy-on-kidney-function-in-patients-with-ckd
#10
Meghan E Sise, Elke Backman, Guillermo A Ortiz, Gregory L Hundemer, Nneka N Ufere, Donald F Chute, Joseph Brancale, Dihua Xu, Jessica Wisocky, Ming V Lin, Arthur Y Kim, Ravi Thadhani, Raymond T Chung
BACKGROUND AND OBJECTIVES: Hepatitis C virus infection is common in patients with CKD and leads to accelerated progression to ESRD. Sofosbuvir is a potent direct-acting antiviral therapy against hepatitis C virus; however, there are concerns about its safety in patients with CKD. The objective of our study was to determine the safety and efficacy of sofosbuvir in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We studied a retrospective observational cohort of patients with CKD defined by eGFR<60 ml/min per 1...
September 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28875481/proteinuria-predicts-resistance-to-antiplatelet-therapy-in-ischemic-stroke
#11
Gemlyn George, Nikul Patel, Cecilia Jang, David Wheeler, Sridhara S Yaddanapudi, Jonathan Dissin, Ramani Balu, Janani Rangaswami
The occurrence of a stroke while on antiplatelet agents presents a therapeutic dilemma. One of the main causes for recurrent strokes is antiplatelet resistance more commonly known as high on treatment platelet reactivity (HTPR). Prior studies have established that proteinuria is associated with HTPR following myocardial infarction. Here, we investigated whether dipstick proteinuria correlates with HTPR in patients presenting with stroke. We performed a retrospective cohort analysis of 102 patients admitted for a recurrent ischemic stroke that had either a VerifyNow aspirin or VerifyNow clopidogrel laboratory test performed to assess platelet reactivity...
September 5, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28871455/clinical-characteristics-and-outcomes-of-biopsy-proven-diabetic-nephropathy
#12
Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li
Kidney damage is common in patients with diabetes mellitus (DM). However, whether the type of kidney damage can be reliably diagnosed using clinical data alone remains unclear. Predictive factors for diabetic nephropathy (DN) outcomes are also poorly understood. In this study, the clinical manifestations of 111 cases of biopsy-proven DN were described, and the clinical and pathological parameters of patients with different DN outcomes were compared. Results showed that long DM duration ( > 10 years in 32...
September 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28871454/non-genetic-mechanisms-of-diabetic-nephropathy
#13
REVIEW
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomerular basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries...
September 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28871079/sirt6-deficiency-exacerbates-podocyte-injury-and-proteinuria-through-targeting-notch-signaling
#14
Min Liu, Kaili Liang, Junhui Zhen, Meng Zhou, Xiaojie Wang, Ziying Wang, Xinbing Wei, Yan Zhang, Yu Sun, Zhuanli Zhou, Hua Su, Chun Zhang, Ningjun Li, Chengjiang Gao, Jun Peng, Fan Yi
Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch signaling. Sirt6 is downregulated in renal biopsies from patients with podocytopathies and its expression correlates with glomerular filtration rate. Podocyte-specific deletion of Sirt6 exacerbates podocyte injury and proteinuria in two independent mouse models, diabetic nephropathy, and adriamycin-induced nephropathy...
September 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28864001/associations-between-the-levels-of-soluble-pro-renin-receptor-in-maternal-and-umbilical-cord-blood-and-hypertensive-disorder-of-pregnancy
#15
Yukiko Mikami, Yasushi Takai, Tatsuya Narita, Sumiko Era, Yoshihisa Ono, Masahiro Saitoh, Kazunori Baba, Kikumi Matsuoka, Hiroyuki Seki
INTRODUCTION: The prorenin (PR) receptor [(P)RR] contributes to the regulation of the tissue renin-angiotensin system (RAS) and Wnt signaling, which is involved in embryogenesis and the pathological progression of malignant tumors and diabetes mellitus. Placental (P)RR is significantly upregulated in placental tissues from preeclamptic women. However, because it cannot be examined during pregnancy, the chronological relationship between the acceleration of tissue RAS and the disease state of hypertensive disorder of pregnancy (HDP) has not been reported...
September 2017: Placenta
https://www.readbyqxmd.com/read/28858978/microalbuminuria-and-plasma-aldosterone-levels-in-nondiabetic-treatment-na%C3%A3-ve-patients-with-hypertension
#16
Cristiana Catena, GianLuca Colussi, Flavia Martinis, Marileda Novello, Leonardo A Sechi
OBJECTIVES: Identification of factors that contribute to urinary albumin losses in hypertensive nephropathy is crucial for prevention of renal deterioration. The aim of this study was to investigate the relationship of low-grade albuminuria with plasma aldosterone levels in treatment-naïve hypertensive patients free of additional comorbidities that might affect renal function. METHODS: In 242 newly diagnosed patients with uncomplicated primary hypertension, we obtained duplicate 24-h urine collections for measurement of urinary albumin/creatinine ratio (UACR) and measured plasma aldosterone levels...
August 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28852486/diabetes-deafness-and-renal-disease
#17
Iolanda Godinho, Joana Gameiro, Sofia Jorge, Fernando Abreu, Marta Neves, José António Lopes, António Gomes da Costa
Deafness, kidney disease and diabetes are not a usual association, neither is a family history of these diseases. We present the case of a 47-year-old woman with non-nephrotic proteinuria, no haematuria, normal renal function, sensorineural hearing loss, recently diagnosed diabetes and maculopathy. There was a maternal family history of deafness, diabetes and renal disease. Renal biopsy revealed focal and segmental glomerulosclerosis (FSGS), leading to the pursuit of an m.3243A > G mitochondrial mutation and diagnosis of maternally inherited diabetes and deafness...
August 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28844155/effects-of-aliskiren-on-mortality-cardiovascular-outcomes-and-adverse-events-in-patients-with-diabetes-and-cardiovascular-disease-or-risk-a-systematic-review-and-meta-analysis-of-13-395-patients
#18
Sean L Zheng, Alistair J Roddick, Salma Ayis
BACKGROUND: Aliskiren was shown to increase adverse events in patients with diabetes and concomitant renin-angiotensin blockade. We aim to investigate the efficacy and safety of aliskiren in patients with diabetes and increased cardiovascular risk or established cardiovascular disease. METHODS: MEDLINE and Embase were searched for prospective studies comparing addition of aliskiren to standard medical therapy in patients with diabetes and cardiovascular disease, or ⩾1 additional cardiovascular risk factor (hypertension, abnormal lipid profile, microalbuminuria/proteinuria, chronic kidney disease)...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28843828/vinpocetine-mitigates-proteinuria-and-podocytes-injury-in-a-rat-model-of-diabetic-nephropathy
#19
Walaa Wadie, Dalia M El-Tanbouly
Podocyte injury and glomerular basement membrane thickening have been considered as essential pathophysiological events in diabetic nephropathy. The aim of this study was to investigate the possible beneficial effects of vinpocetine on diabetes-associated renal damage. Male Wistar rats were made diabetic by injection of streptozotocin (STZ). Diabetic rats were treated with vinpocetine in a dose of 20mg/kg/day for 6 weeks. Treatment with vinpocetine resulted in a marked decrease in the levels of blood glucose, glycosylated haemoglobin, creatinine, blood urea nitrogen, urinary albumin and albumin/creatinine ratio along with an elevation in creatinine clearance rate...
August 24, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28842605/deficient-insulin-mediated-upregulation-of-the-equilibrative-nucleoside-transporter-2-contributes-to-chronically-increased-adenosine-in-diabetic-glomerulopathy
#20
Sebastián Alarcón, Wallys Garrido, Claudio Cappelli, Raibel Suárez, Carlos Oyarzún, Claudia Quezada, Rody San Martín
Deficient insulin signaling is a key event mediating diabetic glomerulopathy. Additionally, diabetic kidney disease has been related to increased levels of adenosine. Therefore, we tested a link between insulin deficiency and dysregulated activity of the equilibrative nucleoside transporters (ENTs) responsible for controlling extracellular levels of adenosine. In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine...
August 25, 2017: Scientific Reports
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