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https://www.readbyqxmd.com/read/29786974/embryonic-exposure-to-environmentally-relevant-concentrations-of-a-brominated-flame-retardant-reduces-the-size-of-song-control-nuclei-in-a-songbird
#1
Margaret L Eng, Viktoria Winter, John E Elliott, Scott A MacDougall-Shackleton, Tony D Williams
Environmental contaminants have the potential to act as developmental stressors and impair development of song and the brain of songbirds, but they have been largely unstudied in this context. 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) is a brominated flame retardant congener that has demonstrated endocrine disrupting effects, and has pervaded the global environment. We assessed the effects of in ovo exposure to environmentally relevant levels of BDE-99 on the neuroanatomy of the song-control system in a model songbird species, the zebra finch (Taeniopygia guttata)...
May 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29715145/liver-function-in-areas-of-hepatic-venous-congestion-after-hepatectomy-for-liver-cancer-99m-tc-gsa-spect-ct-fused-imaging-study
#2
Morikatsu Yoshida, Toru Beppu, Shinya Shiraishi, Noriko Tsuda, Fumi Sakamoto, Kunitaka Kuramoto, Hirohisa Okabe, Hidetoshi Nitta, Katsunori Imai, Seiji Tomiguchi, Hideo Baba, Yasuyuki Yamashita
Background/Aim: The sacrifice of a major hepatic vein can cause hepatic venous congestion (HVC). We evaluated the effects of HVC on regional liver function using the liver uptake value (LUV), that was calculated from 99m Tc-labeled-galactosyl-human-serum-albumin ( 99m Tc-GSA) single-photon emission computed tomography (SPECT) /contrast-enhanced computed tomography (CE-CT) fused images. Patients and Methods: Sixty-two patients underwent 99m Tc-GSA SPECT/CE-CT prior to hepatectomy for liver cancer and at 7 days after surgery were divided into groups with (n=8) and without HVC (n=54)...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29709609/physiological-identification-of-cortico-striatal-projection-neurons-for-song-control-in-bengalese-finches
#3
Neal A Hessler, Kazuo Okanoya
The avian song system is a group of brain areas specialized for vocal learning and production of song. A major cortical control area, HVC, projects both to a motor output circuit and to a striatal area in the anterior forebrain pathway. These projections are made by two groups of neurons, with mainly distinct roles in either programming vocal production or regulating vocal plasticity. In order to distinguish these two types of projection neurons in singing birds, we recorded unit activity in HVC of anesthetized birds, while stimulating in the anterior forebrain nucleus Area X...
April 27, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29697425/relationship-between-institutional-investment-in-high-value-care-hvc-performance-improvement-and-internal-medicine-residents-perceptions-of-hvc-training
#4
Kira L Ryskina, Cynthia D Smith, Vineet M Arora, Aimee K Zaas, Andrew J Halvorsen, Arlene Weissman, Sandhya Wahi-Gururaj
PURPOSE: To measure the association between institutional investment in high value care (HVC) performance improvement and resident HVC experiences. METHOD: The authors analyzed data from two 2014 surveys assessing institutions' investments in HVC performance improvement as reported by program directors (PDs) and residents' perceptions of the frequency of HVC teaching, participation in HVC-focused quality improvement (QI), and views on HVC topics. The authors measured the association between institutional investment and resident-reported experiences using logistic regression, controlling for program and resident characteristics...
April 24, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29675990/intracranial-administration-of-the-g-protein-coupled-estrogen-receptor-1-antagonist-g-15-selectively-affects-dimorphic-characteristics-of-the-song-system-in-zebra-finches-taeniopygia-guttata
#5
Mahtab Attarhaie Tehrani, Sean L Veney
In zebra finches (Taeniopygia guttata), estradiol contributes to sexual differentiation of the song system but the receptor(s) underlying its action are not exactly known. Whereas mRNA and/or protein for nuclear estrogen receptors ERα and ERβ are minimally expressed, G-protein coupled estrogen receptor 1 (GPER1) has a much greater distribution within neural song regions and the syrinx. At present, however, it is unclear if this receptor contributes to dimorphic development of the song system. To test this, the specific GPER1 antagonist, G-15, was intracranially administered to zebra finches for 25 days beginning on the day of hatching...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29675841/early-life-conditions-that-impact-song-learning-in-male-zebra-finches-also-impact-neural-and-behavioral-responses-to-song-in-females
#6
Kendra B Sewall, Rindy C Anderson, Jill A Soha, Susan Peters, Stephen Nowicki
Early life stressors can impair song in songbirds by negatively impacting brain development and subsequent learning. Even in species in which only males sing, early life stressors might also impact female behavior and its underlying neural mechanisms, but fewer studies have examined this possibility. We manipulated brood size in zebra finches to simultaneously examine the effects of developmental stress on male song learning and female behavioral and neural response to song. Although adult male HVC volume was unaffected, we found that males from larger broods imitated tutor song less accurately...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29605049/exploring-the-impact-of-income-and-race-on-survival-for-women-with-advanced-ovarian-cancer-undergoing-primary-debulking-surgery-at-a-high-volume-center
#7
Renee A Cowan, Jill Tseng, Narisha Ali, Helen Dearie, Vijayashree Murthy, Renee L Gennarelli, Alexia Iasonos, Nadeem R Abu-Rustum, Dennis S Chi, Kara C Long Roche, Carol L Brown
OBJECTIVE: To evaluate patients with advanced ovarian cancer (OC) undergoing primary debulking surgery (PDS) at a high-volume center (HVC), to determine whether socio-demographic disparities in PDS outcome and overall survival (OS) were present. METHODS: All patients with stages IIIB-IV high-grade OC undergoing PDS at our institution from 1/2001-12/2013 were identified. Patients self-identified race/ethnicity as non-Hispanic White (NHW), non-Hispanic Black (NHB), Asian (A), or Hispanic (H)...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29577283/morphological-characterization-of-hvc-projection-neurons-in-the-zebra-finch-taeniopygia-guttata
#8
Sam E Benezra, Rajeevan T Narayanan, Robert Egger, Marcel Oberlaender, Michael A Long
Singing behavior in the adult male zebra finch is dependent upon the activity of a cortical region known as HVC (proper name). The vast majority of HVC projection neurons send primary axons to either the downstream premotor nucleus RA (primary motor cortex) or Area X (basal ganglia), which play important roles in song production or song learning, respectively. In addition to these long-range outputs, HVC neurons also send local axon collaterals throughout that nucleus. Despite their implications for a range of circuit models, these local processes have never been completely reconstructed...
March 25, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29569407/neurotensin-and-neurotensin-receptor-1-mrna-expression-in-song-control-regions-changes-during-development-in-male-zebra-finches
#9
Devin P Merullo, Chinweike N Asogwa, Miguel Sanchez-Valpuesta, Shin Hayase, Bikash R Pattnaik, Kazuhiro Wada, Lauren V Riters
Learned vocalizations are important for communication in some vertebrate taxa. The neural circuitry for the learning and production of vocalizations is well-known in songbirds, many of which learn songs initially during a critical period early in life. Dopamine is essential for motor learning, including song learning, and dopamine-related measures change throughout development in song-control regions such as HVC, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), Area X, and the robust nucleus of the arcopallium (RA)...
March 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29561435/comparison-of-high-and-low-viscosity-cement-in-the-treatment-of-vertebral-compression-fractures-a-systematic-review-and-meta-analysis
#10
Zhao-Fei Zhang, He Huang, Shuai Chen, Dong-Hua Liu, Yong-Hui Feng, Chun-Liang Xie, Feng Jiao
BACKGROUND: High-viscosity cement (HVC) has been gradually applied in percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). Although HVC has been reported to reduce cement leakage, different opinions exist. To assess the complications of HVC in cement leakage in the treatment of vertebral compression fractures and to evaluate the clinical effect of HVC compared with low-viscosity cement (LVC). METHODS: EMBASE, PubMed, Science Direct, Google Scholar and Cochrane Library databases were comprehensively searched from their inception to August 2017...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29530259/modification-of-hostile-interpretation-bias-in-depression-a-randomized-controlled-trial
#11
Hillary L Smith, Kirsten H Dillon, Jesse R Cougle
Interpretation Bias Modification (IBM) is gaining attention in the literature as an intervention that alters cognitive biases and reduces associated symptoms. Forty, primarily college-aged, non-treatment-seeking adults with major depressive disorder (MDD) were randomly assigned to receive either IBM targeting hostile interpretation bias (IBM-H) or a healthy video control (HVC) condition. Compared to those in HVC, participants in IBM-H reported more benign interpretations and fewer hostile interpretations at posttreatment...
March 2018: Behavior Therapy
https://www.readbyqxmd.com/read/29517522/current-and-optimal-training-in-high-value-care-in-the-internal-medicine-clerkship-a-national-curricular-needs-assessment
#12
Danelle Cayea, Kim Tartaglia, Amit Pahwa, Heather Harrell, Amy Shaheen, Valerie J Lang
PURPOSE: The clinical skills needed to practice high-value care (HVC) are core to all medical disciplines. Medical students form practice habits early and HVC instruction is essential to this formation. The purpose of this study was to describe the state of HVC instruction and assessment in internal medicine clerkships and identify needs for additional curricula. METHOD: In 2014, the Clerkship Directors in Internal Medicine conducted its annual survey of 121 U.S...
March 6, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29496057/effect-of-adjuvant-radiotherapy-treatment-center-volume-on-overall-survival
#13
Ramez Philips, Daniel Martin, Antoine Eskander, Jeffrey Schord, Nicole Brown, Songzhu Zhao, Guy Brock, Bhavna Kumar, Ricardo Carrau, Enver Ozer, Amit Agrawal, Stephen Y Kang, James W Rocco, David Schuller, Syed Ali, Dukagjin Blakaj, Aashish Bhatt, John Grecula, Theodoros Teknos, Virginia Diavolitsis, Matthew Old
OBJECTIVES: to examine the impact of radiotherapy center volume on overall survival in patients with oral cavity and oropharyngeal squamous cell carcinoma getting adjuvant radiation therapy after receiving surgery at a high-volume center. MATERIALS AND METHODS: a retrospective study was conducted on patients with oral cavity squamous cell carcinoma or oropharyngeal squamous cell carcinoma treated surgically at a tertiary institution from 2000 to 2012 who received adjuvant radiotherapy...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29459805/-hepatitis-b-and-c-prevalence-in-a-blood-bank-at-general-hospital-in-callao-peru
#14
Liliana Alvarez, Paul Jesús Tejada-Llacsa, Giannina Melgarejo-García, Gabriel Berto, Pedro Montes Teves, Eduardo Monge
OBJECTIVE: The aim of the present study was to determine the prevalence of sero positivity for HBsAg, Anti-HBcAg and AntiHVC in the blood bank of Hospital Daniel Carrion during the period 2010 - 2012. MATERIALS AND METHODS: Retrospective cross-sectional study. Potential donors who met the inclusion criteria were included. Sociodemographic factors, risk behaviors were gathered. A descriptive analysis was performed with STATA 14. RESULTS: 13,887 potential blood donors of the HNDAC between January 2010 and December 2012 were identified...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29437836/prospective-observational-study-on-high-value-care-topics-discussed-on-multidisciplinary-rounds
#15
Jimmy B Beck, Corrie E McDaniel, Miranda C Bradford, Doug Brock, Carolyn D Sy, Tiffany Chen, Jeffrey Foti, Andrew A White
OBJECTIVES: Establishing a high-value care (HVC) culture within an institution requires a multidisciplinary commitment and participation. Bedside rounds provide an ideal environment for role modeling and learning behaviors that promote an HVC culture. However, little is understood regarding the types of HVC discussions that take place at the bedside and who participates in those discussions. METHODS: A prospective observational study at a tertiary-care, university-affiliated, free-standing children's hospital...
March 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29234861/neural-coding-of-sound-envelope-structure-in-songbirds
#16
Santiago Boari, Ana Amador
Songbirds are a well-established animal model to study the neural basis of learning, perception and production of complex vocalizations. In this system, telencephalic neurons in HVC present a state-dependent, highly selective response to auditory presentations of the bird's own song (BOS). This property provides an opportunity to study the neural code behind a complex motor behavior. In this work, we explore whether changes in the temporal structure of the sound envelope can drive changes in the neural responses of highly selective HVC units...
March 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29229942/a-neuronal-signature-of-accurate-imitative-learning-in-wild-caught-songbirds-swamp-sparrows-melospiza-georgiana
#17
Dana L Moseley, Narendra R Joshi, Jonathan F Prather, Jeffrey Podos, Luke Remage-Healey
In humans and other animals, behavioural variation in learning has been associated with variation in neural features like morphology and myelination. By contrast, it is essentially unknown whether cognitive performance scales with electrophysiological properties of individual neurons. Birdsong learning offers a rich system to investigate this topic as song acquisition is similar to human language learning. Here, we address the interface between behavioural learning and neurophysiology in a cohort of wild-caught, hand-reared songbirds (swamp sparrows, Melospiza georgiana)...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29218745/expression-of-the-potassium-chloride-co-transporter-kcc2-within-the-avian-song-system
#18
Christopher E Vaaga, Kimberly E Miller, Ágnes L Bodor, David J Perkel
Songbirds learn to produce vocalizations early in life by listening to, then copying the songs of conspecific males. The anterior forebrain pathway, homologous to a basal ganglia-forebrain circuit, is essential for song learning. The projection between the striato-pallidal structure, Area X, and the medial portion of the dorsolateral thalamic nucleus (DLM) is strongly hyperpolarizing in adults, due to a very negative chloride reversal potential (Person & Perkel, Neuron 46:129-140, 2005). The chloride reversal potential is determined, in part, by the expression level of a neuron-specific potassium-chloride cotransporter, KCC2, which is developmentally upregulated in mammals...
April 15, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29209770/androgen-and-estrogen-sensitivity-of-bird-song-a-comparative-view-on-gene-regulatory-levels
#19
REVIEW
Carolina Frankl-Vilches, Manfred Gahr
Singing of songbirds is sensitive to testosterone and its androgenic and estrogenic metabolites in a species-specific way. The hormonal effects on song pattern are likely mediated by androgen receptors (AR) and estrogen receptor alpha (ERα), ligand activated transcription factors that are expressed in neurons of various areas of the songbirds' vocal control circuit. The distribution of AR in this circuit is rather similar between species while that of ERα is species variant and concerns a key vocal control area, the HVC (proper name)...
January 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29178838/hepatitis-c-virus-eradication-improves-immediate-and-delayed-episodic-memory-in-patients-treated-with-interferon-and-ribavirin
#20
Mary Ellen Dias Barbosa, Ana Luiza Zaninotto, Daniel Ferraz de Campos Mazo, Mario Guimarães Pessoa, Cláudia Pinto Marques Souza de Oliveira, Flair José Carrilho, Alberto Queiroz Farias
BACKGROUND: Chronic hepatitis C virus (HCV) infection is associated with impairment of cognitive function and mood disorders. Our aim was to evaluate the impact of sustained virological response (SVR) on cognitive function and mood disorders. METHOD: A prospective exploratory one arm study was conducted. Adult clinically compensated HVC patients were consecutively recruited before treatment with interferon and ribavirin for 24 to 48 weeks, according to HCV genotype...
November 25, 2017: BMC Gastroenterology
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