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Copper deficiency

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https://www.readbyqxmd.com/read/29784876/chca-1-is-a-copper-regulated-ctr1-homolog-required-for-normal-development-copper-accumulation-and-copper-sensing-behavior-in-caenorhabditis-elegans
#1
Sai Yuan, Anuj Kumar Sharma, Alexandria Richart, Jaekwon Lee, Byung-Eun Kim
Copper (Cu) plays key roles in catalytic and regulatory biochemical reactions essential for normal growth, development, and health. Dietary Cu deficiencies or mutations in Cu homeostasis genes can lead to abnormal musculoskeletal development, cognitive disorders, and poor growth. In yeast and mammals, Cu is acquired through the activities of the Ctr1 family of high-affinity Cu transporters. However, the mechanisms of systemic responses to dietary or tissue-specific Cu deficiency remain unclear. Here, taking advantage of the animal model Caenorhabditis elegans for studying whole-body Cu homeostasis, we investigated the role of a C...
May 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29773169/comparison-of-the-effect-of-dietary-copper-nanoparticles-and-one-copper-ii-salt-on-the-metabolic-and-immune-status-in-a-rat-model
#2
Ewelina Cholewińska, Jerzy Juśkiewicz, Katarzyna Ognik
The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two different chemical forms (carbonate and nanoparticles) on metabolic, immune and antioxidant status in a rat model. Five experimental treatments (8 rats in each) were used to test different dosages of Cu added to the diet (standard -6.5 mg/kg, half the standard dosage -3.25 mg/kg, and no added Cu as a negative control) and two sources of added copper (standard -CuCO3 and copper nanoparticles -CuNPs). Blood and urine samples were collected from all the animals after four weeks of treatment...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29767800/copper-requirements-of-broiler-breeder-hens
#3
E Berwanger, S L Vieira, C R Angel, L Kindlein, A N Mayer, M A Ebbing, M Lopes
One-hundred-twenty Cobb 500 hens, 20 wk of age, were randomly allocated into individual cages with the objective of estimating Cu requirements. After being fed a Cu deficient diet for 4 wk, hens were fed diets with graded increments of supplemental Cu (0.0; 3.5; 7.0; 10.5; 14; and 17.5 ppm) from Cu sulfate (CuSO4 5H2O), totaling 2.67; 5.82; 9.38; 12.92; 16.83; and 20.19 ppm analyzed Cu in feeds for 20 weeks. Estimations of Cu requirements were done using exponential asymptotic (EA), broken line quadratic (BLQ), and quadratic polynomial (QP) models...
May 15, 2018: Poultry Science
https://www.readbyqxmd.com/read/29759248/qualitative-and-quantitative-analysis-of-human-nails-to-find-correlation-between-nutrients-and-vitamin-d-deficiency-using-libs-and-icp-aes
#4
M A Almessiere, R Altuwiriqi, M A Gondal, R K AlDakheel, H F Alotaibi
In this work, we analysed human fingernails of people who suffer from vitamin D deficiency using the laser-induced breakdown spectroscopy(LIBS) and inductively coupled plasma atomic emission spectroscopy (ICP-AES)techniques. The measurements have been conducted on 71 nail samples collected randomly from volunteers of different genders and ages ranged between 20 and 50 years. The main aim of this study is to find the correlation between vitamin D deficiency and the intensity of some dominated lines in the LIBS spectra...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29757950/changes-in-arsenic-copper-iron-manganese-and-zinc-levels-resulting-from-the-application-of-poultry-litter-to-agricultural-soils
#5
Richard D Foust, Michael Phillips, Killian Hull, Dariia Yehorova
Twelve applications of poultry litter were made to a 2.1-ha field located in the Shenandoah Valley of Virginia, United States (USA), between March 1999 and August 2014. The field was planted with bermudagrass ( Cynodon dactylon ) and used as a pasture on an active farm. Copper, iron, manganese, zinc, and arsenic concentrations in the poultry litter were measured, and the application rates of these metals were calculated. The median application rates were: Cu, 1.32 kg/ha, Fe, 5.57 kg/ha, Mn, 1.80 kg/ha, Zn, 1...
May 14, 2018: Toxics
https://www.readbyqxmd.com/read/29745398/copper-catalyzed-cross-coupling-of-aryl-primary-alkyl-and-secondary-alkylboranes-with-heteroaryl-bromides
#6
Allison M Bergmann, Adam M Oldham, Wei You, M Kevin Brown
A method for the Cu-catalyzed cross-coupling of both aryl and alkylboranes with aryl bromides is described. The method employs an inexpensive Cu-catalyst and functions for a variety of heterocyclic as well as electron deficient aryl bromides. In addition, aryl iodides of varying substitution patterns and electronic properties work well.
May 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29743987/critical-role-of-zinc-as-either-an-antioxidant-or-a-prooxidant-in-cellular-systems
#7
REVIEW
Sung Ryul Lee
Zinc is recognized as an essential trace metal required for human health; its deficiency is strongly associated with neuronal and immune system defects. Although zinc is a redox-inert metal, it functions as an antioxidant through the catalytic action of copper/zinc-superoxide dismutase, stabilization of membrane structure, protection of the protein sulfhydryl groups, and upregulation of the expression of metallothionein, which possesses a metal-binding capacity and also exhibits antioxidant functions. In addition, zinc suppresses anti-inflammatory responses that would otherwise augment oxidative stress...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29741537/copper-deficiency-and-myelopathy-after-bariatric-surgery-authors-reply
#8
J Oben, P Cordero
No abstract text is available yet for this article.
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29741536/copper-deficiency-and-myelopathy-after-bariatric-surgery
#9
O M Jolobe
No abstract text is available yet for this article.
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29738306/the-biofilm-matrix-polysaccharides-cellulose-and-alginate-both-protect-pseudomonas-putida-mt-2-against-reactive-oxygen-species-generated-under-matric-stress-and-copper-exposure
#10
Nanna B Svenningsen, Esteban Martínez-García, Mette H Nicolaisen, Victor de Lorenzo, Ole Nybroe
In natural environments most bacteria live in biofilms embedded in complex matrices of extracellular polymeric substances (EPS). This lifestyle is known to increase protection against environmental stress. Pseudomonas putida mt-2 harbours genes for the production of at least four different EPS polysaccharides, including alginate and cellulose. Little is known about the functional properties of cellulose, while alginate attenuates the accumulation of reactive oxygen species (ROS) caused by matric stress. By using mutants that are deficient in either alginate or cellulose production we show that even cellulose attenuates the accumulation of matric stress-induced ROS for cells in biofilms...
May 8, 2018: Microbiology
https://www.readbyqxmd.com/read/29737252/does-ceruloplasmin-defend-against-neurodegenerative-diseases
#11
Bo Wang, Xiao-Ping Wang
Ceruloplasmin (CP) is the major copper transport protein in plasma, mainly produced by the liver. Glycosylphosphatidylinositol-linked CP (GPI-CP) is the predominant form expressed in astrocytes of the brain. A growing body of evidence has demonstrated that CP is an essential protein in body with multiple functions such as regulating the homeostasis of copper and iron ions, ferroxidase activity, oxidizing organic amines, and preventing the formation of free radicals. In addition, as an acute-phase protein, CP is induced during inflammation and infection...
May 7, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29730411/evaluation-of-the-safe-application-of-copper-nonylphenolsulfonate-and-hexaconazole-in-wax-gourd-under-field-conditions
#12
Duoduo Jiang, Lifang Duan, Runan Li, Xinglu Pan, Yan Tao, Xiaohu Wu, Jun Xu, Xingang Liu, Fengshou Dong, Yongquan Zheng
Wax gourd is a popular vegetable and the new organic copper pesticide product of copper nonylphenolsulfonate and hexaconazole was firstly recommended to control the serious disease powdery mildew frequently occurred in wax gourd. However, it is still a concern for data deficiency of residue amounts of these two pesticides in edible portion of wax gourd and the persistence in environment. In this study, the dissipation and residue of copper nonylphenolsulfonate and hexaconazole in wax gourd and soil were investigated...
May 3, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29716882/vacuolization-in-myeloid-and-erythroid-precursors-in-a-child-with-menkes-disease
#13
Seçil Sayın, Şule Ünal, Mualla Cetin, Fatma Gumruk
A five year-old boy, who was under follow-up with a clinical and biochemical diagnosis of Menkes Disease (MD) since ten months of age, was admitted with diarrhea. On examination he had a characteristic cherubic face hypopigmented, sparse hair, hepatosplenomegaly, hypotonia with brisk deep tendon reflexes. Hemogram revealed: Hb:5.5g/dL, Hct:16.2%, RBC:1.69x1012/L, MCV:95.8fL, MCH:32.3pg, RDW:19.2%, WBC:2.2x109/L and platelet count;157x109/L. Serum vitamin B12 level was 575pg/mL. Serum copper level was 81μg/dL and serum zinc level was 152μg/dL...
April 30, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29697861/microglial-mhc-class-ii-is-dispensable-for-experimental-autoimmune-encephalomyelitis-and-cuprizone-induced-demyelination
#14
Yochai Wolf, Anat Shemer, Liron Levy-Efrati, Mor Gross, Jung-Seok Kim, Adrien Engel, Eyal David, Louise Chappell-Maor, Jonathan Grozovski, Ron Rotkopf, Inbal Biton, Raya Eilam-Altstadter, Steffen Jung
Microglia are resident immune cells in the central nervous system (CNS), strategically positioned to clear dead cells and debris, and orchestrate CNS inflammation and immune defense. In steady state, these macrophages lack major histocompatibility complex class II (MHCII) expression, but microglia activation can be associated with MHCII induction. Whether microglial MHCII serves antigen presentation for critical local T cell re-stimulation in CNS auto-immune disorders or modulates microglial signaling output remains under debate...
April 26, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29695584/copper-deficiency-anemia-and-neutropenia-due-to-ketogenic-diet
#15
Alan Chin
Copper deficiency is an uncommon cause of hematologic abnormalities in children that is often overlooked or misdiagnosed. Although cases have been reported because of malabsorption syndromes or after gastrointestinal surgeries, we report a case of copper deficiency-associated anemia and neutropenia in a child because of dietary restrictions, specifically, transitioning from a formula-based ketogenic diet to a pureed food-based ketogenic diet. On copper supplementation, the patient's anemia and neutropenia resolved...
April 25, 2018: Pediatrics
https://www.readbyqxmd.com/read/29659961/multi-copper-ferroxidase-deficient-mice-have-increased-brain-iron-concentrations-and-learning-and-memory-deficits
#16
Jiashuo Zheng, Ruiwei Jiang, Min Chen, Zaitunamu Maimaitiming, Junzhuo Wang, Gregory J Anderson, Chris D Vulpe, Joshua L Dunaief, Huijun Chen
Background: The accumulation of iron occurs in the central nervous system (CNS) in several neurodegenerative diseases. Although multi-copper ferroxidases (MCFs) play an important role in cellular iron metabolism and homeostasis, the mechanism of MCFs in the CNS remains unclear. Objective: The aim was to study the role of MCFs in CNS iron metabolism and homeostasis by using hephaestin/ceruloplasmin (Heph/Cp) double knockout (KO) mice. Methods: Heph/Cp double KO male mice were generated by crossing both single KO mice...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29629291/zinc-copper-cd4-t-cell-count-and-some-hematological-parameters-of-hiv-infected-subjects-in-southern-nigeria
#17
Enosakhare A Asemota, Ifeyinwa M Okafor, Henshaw U Okoroiwu, Ewaro R Ekong, Stanley Obialor Anyanwu, Esienanwan Esien Efiong, Francis Udomah
Background: Low concentration of trace elements has been associated with poor prognosis and mortality in HIV infection. Methods: A cross sectional study was conducted among 100 HIV-infected subjects (70 were on ART treatment, while 30 were ART naïve). Fifty (50) apparently healthy controls were enrolled. Concentration of serum levels of zinc and copper was done using atomic absorption spectrometric method, while complete blood count was determined using automated blood analyzer...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29626757/nmta-a-novel-metallothionein-of-anabaena-sp-strain-pcc-7120-imparts-protection-against-cadmium-stress-but-not-oxidative-stress
#18
Divya T V, Pallavi Chandwadkar, Celin Acharya
Metallothioneins (MTs) are low molecular weight, sulfhydryl-containing, cysteine-rich, metal-binding proteins. Eukaryotes have multiple metallothionein genes; however, there is dearth of reports on prokaryotic metallothioneins. Bacterial MTs with SmtA from Synechococcus PCC 7942 as prototype have been studied in the context of cadmium detoxification. In this study, a smtA related ORF, namely nmtA, was identified in the heterocystous, nitrogen-fixing cyanobacterium, Anabaena PCC 7120. A recombinant N-terminal histidine-tagged Anabaena NmtA protein was overexpressed in Escherichia coli and purified...
March 30, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29616070/the-rice-rolled-fine-striped-rfs-chd3-mi-2-chromatin-remodeling-factor-epigenetically-regulates-genes-involved-in-oxidative-stress-responses-during-leaf-development
#19
Sung-Hwan Cho, Chung-Hee Lee, Eunji Gi, Yehyun Yim, Hee-Jong Koh, Kiyoon Kang, Nam-Chon Paek
In rice ( Oryza sativa ), moderate leaf rolling increases photosynthetic competence and raises grain yield; therefore, this important agronomic trait has attracted much attention from plant biologists and breeders. However, the relevant molecular mechanism remains unclear. Here, we isolated and characterized Rolled Fine Striped ( RFS ), a key gene affecting rice leaf rolling, chloroplast development, and reactive oxygen species (ROS) scavenging. The rfs-1 gamma-ray allele and the rfs-2 T-DNA insertion allele of RFS failed to complement each other and their mutants had similar phenotypes, producing extremely incurved leaves due to defective development of vascular cells on the adaxial side...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29615045/a-common-mechanism-explains-the-induction-of-aerobic-fermentation-and-adaptive-antioxidant-response-in-phaffia-rhodozyma
#20
Anahí Martínez-Cárdenas, Cipriano Chávez-Cabrera, Jazmín M Vasquez-Bahena, Luis B Flores-Cotera
BACKGROUND: Growth conditions that bring about stress on Phaffia rhodozyma cells encourage the synthesis of astaxanthin, an antioxidant carotenoid, which protects cells against oxidative damage. Using P. rhodozyma cultures performed with and without copper limitation, we examined the kinetics of astaxanthin synthesis along with the expression of asy, the key astaxanthin synthesis gene, as well as aox, which encodes an alternative oxidase protein. RESULTS: Copper deficiency had a detrimental effect on the rates of oxygen consumption and ethanol reassimilation at the diauxic shift...
April 3, 2018: Microbial Cell Factories
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