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Copper deficiency

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https://www.readbyqxmd.com/read/28926949/influence-of-freeze-drying-and-oven-drying-post-blanching-on-the-nutrient-composition-of-the-edible-insect-ruspolia-differens
#1
Forkwa Tengweh Fombong, Mik Van Der Borght, Jozef Vanden Broeck
The longhorn grasshopper, Ruspolia differens (Serville), plays an important role as a food source across Sub-Saharan Africa, where it is consumed as a delicacy in both rural and urban areas. The effect of two drying methods (freeze-drying and oven-drying), employed after blanching, on the proximate, fatty acid and mineral composition of the two most common morphs was determined. Ruspolia differens grasshoppers were harvested in Uganda and Kenya from wild swarms during the rainy periods of November-December 2016...
September 16, 2017: Insects
https://www.readbyqxmd.com/read/28901753/synthesis-of-a-cu-filled-rh17s15-framework-microwave-polyol-process-versus-high-temperature-route
#2
Maria Roslova, Pavlo Golub, Lars Opherden, Alexander Ovchinnikov, Marc Uhlarz, Alexey I Baranov, Yurii Prots, Anna Isaeva, Mauro Coduri, Thomas Herrmannsdörfer, Joachim Wosnitza, Thomas Doert, Michael Ruck
Metal-rich, mixed copper-rhodium sulfide Cu3-δRh34S30 that represents a new Cu-filled variant of the Rh17S15 structure has been synthesized and structurally characterized. Copper content in the [CuRh8] cubic cluster was found to vary notably dependent on the chosen synthetic route. Full site occupancy was achieved only in nanoscaled Cu3Rh34S30 obtained by a rapid, microwave-assisted reaction of CuCl, Rh2(CH3CO2)4 and thiosemicarbazide at 300 °C in just 30 min; whereas merely Cu-deficient Cu3-δRh34S30 (2...
September 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28889277/neurodegeneration-induced-by-metals-in-caenorhabditis-elegans
#3
Felix Antunes Soares, Daiandra Almeida Fagundez, Daiana Silva Avila
Metals are a component of a variety of ecosystems and organisms. They can generally be divided into essential and nonessential metals. The essential metals are involved in physiological processes once the deficiency of these metals has been associated with diseases. Although iron, manganese, copper, and zinc are important for life, it has been evidenced that they are also involved in neuronal damage in many neurodegenerative disorders. Nonessential metals, which are metals without physiological functions, are present in trace or higher levels in living organisms...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28889275/neurotoxicity-of-copper
#4
Felix Bulcke, Ralf Dringen, Ivo Florin Scheiber
Copper is an essential trace metal that is required for several important biological processes, however, an excess of copper can be toxic to cells. Therefore, systemic and cellular copper homeostasis is tightly regulated, but dysregulation of copper homeostasis may occur in disease states, resulting either in copper deficiency or copper overload and toxicity. This chapter will give an overview on the biological roles of copper and of the mechanisms involved in copper uptake, storage, and distribution. In addition, we will describe potential mechanisms of the cellular toxicity of copper and copper oxide nanoparticles...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28889269/copper-and-alzheimer-s-disease
#5
Zoe K Mathys, Anthony R White
Alzheimer's disease (AD) is the most common form of adult neurode-generation and is characterised by progressive loss of cognitive function leading to death. The neuropathological hallmarks include extracellular amyloid plaque accumulation in affected regions of the brain, formation of intraneuronal neurofibrillary tangles, chronic neuroinflammation, oxidative stress, and abnormal biometal homeostasis. Of the latter, major changes in copper (Cu) levels and localisation have been identified in AD brain, with accumulation of Cu in amyloid deposits, together with deficiency of Cu in some brain regions...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28883881/zinc-and-copper-metabolism-and-risk-of-autism-a-reply-to-sayehmiri-et-al
#6
Keith Fluegge Ba
OBJECTIVE: Sayehmiri et al. recently conducted a meta-analysis to explore the relationship between zinc and copper metabolism and autism spectrum disorders (ASD). Recent reports have elucidated a full behavioral profile of mice exposed to prenatal zinc deficiency and documented a phenotype similar to that found in autism spectrum disorders (ASD). These studies suggest that significant alterations in Zn metabolism may be an important nutritional component in the development of ASD. MATERIALS & METHODS: The idea that prenatal zinc deficiency may be to blame is cursorily challenged...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28881637/cd147-functions-as-the-signaling-receptor-for-extracellular-divalent-copper-in-hepatocellular-carcinoma-cells
#7
Pengfei Ding, Xin Zhang, Shujuan Jin, Bo Duan, Pengxiang Chu, Yufei Zhang, Zhi-Nan Chen, Bin Xia, Fei Song
Elevated copper levels in tumor microenvironment are directly correlated to cancer progression in a variety of malignancies. Copper is required in angiogenesis, and promotes the proliferation and metastasis of cancer cells. However, the molecular mechanism of copper in promoting cancer progression remains elusive. Here we report that CD147 serves as a signaling receptor for extracellular Cu(2+) in hepatocellular carcinoma (HCC) cells. Cu(2+) binds to the extracellular membrane-proximal domain of CD147 and mediates its self-association...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877212/selenium-deficiency-induced-alterations-in-ion-profiles-in-chicken-muscle
#8
Haidong Yao, Xia Zhao, Ruifeng Fan, Hamid Sattar, Jinxin Zhao, Wenchao Zhao, Ziwei Zhang, Yufeng Li, Shiwen Xu
Ion homeostasis plays important roles in development of metabolic diseases. In the present study, we examined the contents and distributions of 25 ions in chicken muscles following treatment with selenium (Se) deficiency for 25 days. The results revealed that in chicken muscles, the top ranked microelements were silicon (Si), iron (Fe), zinc (Zn), aluminum (Al), copper (Cu) and boron (B), showing low contents that varied from 292.89 ppb to 100.27 ppm. After Se deficiency treatment, essential microelements [Cu, chromium (Cr), vanadium (V) and manganese (Mn)], and toxic microelements [cadmium (Cd) and mercury (Hg)] became more concentrated (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28862695/quantifying-the-performance-of-p-type-transparent-conducting-oxides-by-experimental-methods
#9
Karsten Fleischer, Emma Norton, Daragh Mullarkey, David Caffrey, Igor V Shvets
Screening for potential new materials with experimental and theoretical methods has led to the discovery of many promising candidate materials for p-type transparent conducting oxides. It is difficult to reliably assess a good p-type transparent conducting oxide (TCO) from limited information available at an early experimental stage. In this paper we discuss the influence of sample thickness on simple transmission measurements and how the sample thickness can skew the commonly used figure of merit of TCOs and their estimated band gap...
September 1, 2017: Materials
https://www.readbyqxmd.com/read/28856635/umbilical-serum-copper-status-and-neonatal-birth-outcomes-a-prospective-cohort-study
#10
Zhijuan Li, Chunmei Liang, Kun Huang, Shuangqin Yan, Ruiwen Tao, Jie Sheng, Weijun Pan, Xun Xia, Yiran Tao, Haiyun Xiang, Jiahu Hao, Beibei Zhu, Qunan Wang, Peng Zhu, Shilu Tong, Fangbiao Tao
Our study aimed to assess the distribution of copper (Cu) in umbilical cord serum and estimated the association between umbilical serum Cu status and neonatal birth outcomes in a Chinese population. Through the Ma'anShan Birth Cohort Study, 2689 maternal-singleton pairs with detailed birth records and available serum samples were identified. The tertile levels of ln-transformed Cu were used to define low, medium, and high levels for serum Cu. The median for umbilical cord serum Cu was 298.2 μg/L with a range of 123...
August 31, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28852304/wilson-s-disease-prospective-developments-towards-new-therapies
#11
EDITORIAL
Giusy Ranucci, Roman Polishchuck, Raffaele Iorio
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism, caused by mutations in the ATP7B gene. A clear demand for novel WD treatment strategies has emerged. Although therapies using zinc salts and copper chelators can effectively cure WD, these drugs exhibit limitations in a substantial pool of WD patients who develop intolerance and/or severe side effects. Several lines of research have indicated intriguing potential for novel strategies and targets for development of new therapies. Here, we review these new approaches, which comprise correction of ATP7B mutants and discovery of new compounds that circumvent ATP7B-deficiency, as well as cell and gene therapies...
August 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28846434/highly-regioselective-carbamoylation-of-electron-deficient-nitrogen-heteroarenes-with-hydrazinecarboxamides
#12
Zeng-Yang He, Chao-Fan Huang, Shi-Kai Tian
The use of hydrazinecarboxamides as a new class of carbamoylating agents has been established through the dehydrazinative Minisci reaction of electron-deficient nitrogen heteroarenes. A wide range of electron-deficient nitrogen heteroarenes, including isoquinoline, quinoline, pyridine, phenanthridine, quinoxaline, and phthalazine, underwent copper/acid-catalyzed oxidative carbamoylation with hydrazinecarboxamide hydrochlorides to afford structurally diverse nitrogen-heteroaryl carboxamides as single regioisomers in moderate to excellent yields...
August 28, 2017: Organic Letters
https://www.readbyqxmd.com/read/28844937/dimercapto-1-propanesulfonic-acid-dmps-induces-metaphase-ii-mouse-oocyte-deterioration
#13
Sarah R Aldhaheri, Roohi Jeelani, Hamid-Reza Kohan-Ghadr, Sana N Khan, Sasha Mikhael, Christina Washington, Robert T Morris, Husam M Abu-Soud
In light of the recent lead contamination of the water in Flint, Michigan and its potential adverse outcomes, much research and media attention has turned towards the safety profile of commonly used chelators. Dimercapto-1-propanesulfonic acid (DMPS) typically used in the treatment of lead, mercury and arsenic poisoning also displays a high affinity towards transition metals such as zinc and copper, essential for biological functioning. It is given in series of dosages (0.2-0.4g/day) over a long period, and has the ability to enter cells...
August 24, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28841516/from-which-soil-metal-fractions-fe-mn-zn-and-cu-are-taken-up-by-olive-trees-olea-europaea-l-cv-chondrolia-chalkidikis-in-organic-groves
#14
T Chatzistathis, A Papaioannou, D Gasparatos, A Molassiotis
Organic farming has been proposed as an alternative agricultural system to help solve environmental problems, like the sustainable management of soil micronutrients, without inputs of chemical fertilizers. The purposes of this study were: i) to assess Fe, Mn, Zn and Cu bioavailability through the determination of sequentially extracted chemical forms (fractions) and their correlation with foliar micronutrient concentrations in mature organic olive (cv. 'Chondrolia Chalkidikis') groves; ii) to determine the soil depth and the available forms (fractions) by which the 4 metals are taken up by olive trees...
August 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28815023/antibiotic-resistance-ability-to-form-biofilm-and-susceptibility-to-copper-alloys-of-selected-staphylococcal-strains-isolated-from-touch-surfaces-in-polish-hospital-wards
#15
Anna Różańska, Agnieszka Chmielarczyk, Dorota Romaniszyn, Małgorzata Bulanda, Monika Walkowicz, Piotr Osuch, Tadeusz Knych
BACKGROUND: Despite the employment of sanitary regimes, contact transmission of the aetiological agents of hospital infections is still exceedingly common. The issue of microbe transmission becomes particularly important when facing multidrug-resistant microorganisms such as methicillin-resistant staphylococci. In the case of deficiencies in cleaning and disinfection procedures, hospital equipment made of copper alloys can play an important role, complementing traditional hospital hygiene procedures...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28811809/peppered-and-rare-gastric-and-duodenal-pseudomelanosis-a-case-series
#16
Sami Samiullah, Hadi Bhurgri, Arooj Babar, Fatima Samad, Moaz M Choudhary, Michael Demyen
Upper Gastrointestinal (GI) pseudomelanosis is an uncommon entity characterized by endoscopic visualization of speckled dark mucosal pigmentation. While described in the rectum and colon, 'melanosis' or more aptly 'pseudomelanosis' is rare in the duodenum and exceedingly rare in the stomach. Five cases of pseudomelanosis were encountered at our department. Four females and one male were diagnosed, with a mean age of 70 years. All patients exhibited duodenal pseudomelanosis, with one demonstrating gastric antral pseudomelanosis as well...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811697/role-of-iron-and-copper-in-the-pathogenesis-of-parkinson-s-disease
#17
Mohit Kumar Gangania, Jyoti Batra, Suman Kushwaha, Rachna Agarwal
Parkinson's disease (PD) is an old age disorder of basal ganglia which involves oligomerization of α-synuclein protein and formation of intercellular inclusions known as "Lewy bodies" in substantia nigra and caudate nuclei in brain which is progressive in nature. It is second most prevalent neurodegenerative disorder characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes in posture (instability). Both excess and deficiency in levels of transition metals (especially iron, copper) can be detrimental to the central nervous system...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28801722/effect-of-disturbances-of-zinc-and-copper-on-the-physical-and-mental-health-status-of-patients-with-alcohol-dependence
#18
M Ordak, E Bulska, K Jablonka-Salach, A Luciuk, M Maj-Żurawska, H Matsumoto, T Nasierowski, M Wojnar, J Matras, E Muszynska, M Bujalska-Zadrozny
The concentrations of copper and zinc in the tissues of alcohol-addicted people can significantly correlate with the variables describing their mental state. Studies on the homeostasis of zinc in alcohol-dependent patients have often been characterized by low hypozincemia detection. This may be caused by a low content of zinc in blood serum (1%) compared to the average zinc level in the body. Unfortunately, most authors have identified extracellular zinc in their studies. In the available literature, data on the level of copper in patients suffering from alcohol dependence are inconsistent...
August 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28799141/trace-element-and-vitamin-concentrations-in-paediatric-dialysis-patients
#19
Triona Joyce, Frances Court Brown, Dean Wallace, Christopher J D Reid, Manish D Sinha
BACKGROUND: There are few recent data regarding blood micronutrient concentrations and supplementation in children on maintenance dialysis. We investigated micronutrient concentrations following dialysis commencement. METHODS: Retrospective review, including all children on maintenance dialysis (peritoneal dialysis, PD; intermittent haemodialysis, IHD), for nutritional blood concentrations measured over the first 12 months. Patients received pyridoxine and Dialyvit® daily with planned 3-monthly micronutrient concentration monitoring including selenium, manganese, copper, zinc, folate and vitamins A, D, B12 and E...
August 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28797164/universal-surface-engineering-of-transition-metals-for-superior-electrocatalytic-hydrogen-evolution-in-neutral-water
#20
Bo You, Xuan Liu, Guoxiang Hu, Sheraz Gul, Junko Yano, De-En Jiang, Yujie Sun
The development of low-cost hybrid water splitting-biosynthetic systems that mimic natural photosynthesis to achieve solar-to-chemical conversion is of great promise for future energy demands, but often limited by the kinetically sluggish hydrogen evolution reaction (HER) on the surface of nonprecious transition metal catalysts in neutral media. It is thus highly desirable to rationally tailor the reaction interface to boost the neutral HER catalytic kinetics. Herein, we report a general surface nitrogen modification of diverse transition metals (e...
August 22, 2017: Journal of the American Chemical Society
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