keyword
MENU ▼
Read by QxMD icon Read
search

Copper deficiency

keyword
https://www.readbyqxmd.com/read/29351582/sco2-mutations-cause-early-onset-axonal-charcot-marie-tooth-disease-associated-with-cellular-copper-deficiency
#1
Adriana P Rebelo, Dimah Saade, Claudia P Pereira, Amjad Farooq, Tyler C Huff, Lisa Abreu, Carlos T Moraes, Diana Mnatsakanova, Kathy Mathews, Hua Yang, Eric A Schon, Stephan Zuchner, Michael E Shy
Recessive mutations in the mitochondrial copper-binding protein SCO2, cytochrome c oxidase (COX) assembly protein, have been reported in several cases with fatal infantile cardioencephalomyopathy with COX deficiency. Significantly expanding the known phenotypic spectrum, we identified compound heterozygous variants in SCO2 in two unrelated patients with axonal polyneuropathy, also known as Charcot-Marie-Tooth disease type 4. Different from previously described cases, our patients developed predominantly motor neuropathy, they survived infancy, and they have not yet developed the cardiomyopathy that causes death in early infancy in reported patients...
January 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29339045/deficiency-of-dietary-pyridoxine-disturbed-the-intestinal-physical-barrier-function-of-young-grass-carp-ctenopharyngodon-idella
#2
Pei Wu, Xin Zheng, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Yong-An Zhang, Lin Feng
The aim of this study was to assess the effects of dietary pyridoxine (PN) deficiency on intestinal antioxidant capacity, cell apoptosis and intercellular tight junction in young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp (231.85 ± 0.63 g) were fed six diets containing graded levels of PN (0.12-7.48 mg/kg diet) for 10 weeks. At the end of the feeding trial, the fish were challenged with Aeromonas hydrophila for 2 weeks. The results showed that compared with the optimal PN level, PN deficiency (1) increased the contents of reactive oxygen species (ROS), malondialdehyde (MDA) and protein carbonyl (PC), decreased the activities and mRNA levels of antioxidant enzymes such as copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) (P < ...
January 12, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29328033/-elemental-status-of-patients-with-various-forms-of-vitiligo
#3
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, I Charischarishvili
Vitiligo is a multifactorial disease in which, in each specific case of its manifestation, different mechanisms of its pathogenesis and different levels of melanin formation in the skin can be involved. Skin is one of the most metabolically active organs. Carrying out a number of vital functions (barrier, protective, respiratory, excretory, metabolic, immune, etc.), it needs microelementss. Of the 92 naturally occurring chemical elements, 81 are found in the human body. Lack of the vital elements, leads to the emergence of diseases, which are based on deficiency, excess or imbalance of micro- and macroelements in the body...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29325617/wilson-disease-and-related-copper-disorders
#4
Matthew T Lorincz
Copper is a required cofactor for enzymes in critical metabolic pathways. Mutations in copper metabolism genes or abnormalities in copper metabolism result in disease from copper excess or deficiency. Wilson disease (WD) is an autosomal-recessive disease caused by mutations in the ATP7B gene which encodes a copper-transporting ATPase. Over 500 different WD mutations throughout the ATP7B gene have been described, most of which are missense mutations. Mutations in both ATP7B alleles result in abnormal copper metabolism and subsequent toxic accumulation of copper...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29313750/serum-retinol-folic-acid-and-copper-are-associated-with-sperm-abnormalities-in-men-with-obesity
#5
Berniza Calderón, Vital Hevia, Belén Vega-Piñero, Antonia Martín-Hidalgo, Helena Mendez-Del Sol, Héctor F Escobar-Morreale, José I Botella-Carretero
BACKGROUND AND OBJECTIVES: Micronutrients may influence the development and differentiation of sperm cells. The aim of this study was to assess the possible association of deficiencies in several vitamins and trace elements with sperm abnormalities in men with obesity. PARTICIPANTS AND METHODS: Thirty male patients with moderate to severe obesity and ten lean controls who gave written informed consent were included. Anthropometric parameters were recorded. Hormonal and lipid profiles were analyzed, as well as serum concentrations of zinc, copper, retinol, α-tocopherol, 25-hydroxyvitamin D, cobalamin, and folic acid...
January 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29301787/akt2-stabilizes-atp7a-a-copper-transporter-for-sod3-extracellular-superoxide-dismutase-in-vascular-smooth-muscles-novel-mechanism-to-limit-endothelial-dysfunction-in-type-2-diabetes-mellitus
#6
Varadarajan Sudhahar, Mustafa Nazir Okur, Zsolt Bagi, John P O'Bryan, Nissim Hay, Ayako Makino, Vijay S Patel, Shane A Phillips, David Stepp, Masuko Ushio-Fukai, Tohru Fukai
OBJECTIVE: Copper transporter ATP7A (copper-transporting/exporting ATPase) is required for full activation of SOD3 (extracellular superoxide dismutase), which is secreted from vascular smooth muscle cells (VSMCs) and anchors to endothelial cell surface to preserve endothelial function by scavenging extracellular superoxide. We reported that ATP7A protein expression and SOD3 activity are decreased in insulin-deficient type 1 diabetes mellitus vessels, thereby, inducing superoxide-mediated endothelial dysfunction, which are rescued by insulin treatment...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29295524/dietary-copper-reduces-the-hepatotoxicity-of-epigallocatechin-3-gallate-in-mice
#7
Najeeb Ahmed Kaleri, Kang Sun, Le Wang, Jin Li, Wenzheng Zhang, Xuan Chen, Xinghui Li
We developed Cu-deficient, -sufficient and -super nutrition mice models by feeding them with diet containing 1.68, 11.72 or 51.69 mg of Cu/kg for 28 days, respectively. Then, the mice were treated to (-)-epigallocatechin-3-gallate (EGCG, 750 mg/kg BW) by oral in order to assess the acute toxicity of the drug. Following EGCG treatment, the survival rates were 12.5%, 50% and 100% in the Cu-deficient, -sufficient and Cu-super nutrition groups of mice, respectively. Cu level and ceruloplasmin activity in serum were significantly increased with the increase of dietary Cu...
December 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29245216/magnetic-resonance-imaging-of-the-spinal-cord-in-the-evaluation-of-3-patients-with-sensory-neuronopathies-diagnostic-assessment-indications-of-treatment-response-and-impact-of-autoimmunity-a-case-report
#8
Julius Birnbaum, Aliya Lalji, Ezequiel A Piccione, Izlem Izbudak
RATIONALE: Sensory neuronopathy can be a devastating peripheral nervous system disorder. Profound loss in joint position is associated with sensory ataxia, and reflects degeneration of large-sized dorsal root ganglia. Prompt recognition of sensory neuronopathies may constitute a therapeutic window to intervene before there are irreversible deficits. However, nerve-conduction studies may be unrevealing early in the disease course. In such cases, the appearance of dorsal column lesions on spinal-cord MRI can help in the diagnosis...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29237729/the-mammalian-phosphate-carrier-slc25a3-is-a-mitochondrial-copper-transporter-required-for-cytochrome-c-oxidase-biogenesis
#9
Aren Boulet, Katherine E Vest, Margaret K Maynard, Micah G Gammon, Antoinette C Russell, Alexander T Mathews, Shelbie E Cole, Xinyu Zhu, Casey B Phillips, Jennifer Q Kwong, Sheel C Dodani, Scot C Leary, Paul A Cobine
Copper is required for the activity of cytochrome c oxidase (COX), the terminal electron-accepting complex of the mitochondrial respiratory chain. The likely source of copper used for COX biogenesis is a labile pool found in the mitochondrial matrix. In mammals, the proteins that transport copper across the inner mitochondrial membrane remain unknown. We previously reported that the mitochondrial carrier family protein Pic2 in budding yeast is a copper importer. The closest Pic2 orthologue in mammalian cells is the mitochondrial phosphate carrier SLC25A3...
December 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29236516/trace-minerals-intake-risks-and-benefits-for-cardiovascular-health
#10
Noushin Mohammadifard, Karin H Humphries, Carolyn Gotay, Guillermo Mena-Sánchez, Jordi Salas-Salvadó, Ahmad Esmaillzadeh, Andrew Ignaszewski, Nizal Sarrafzadegan
Minerals play a major role in regulating cardiovascular function. Imbalances in electrolyte minerals are frequent and potentially hazardous occurrences that may lead to the development of cardiovascular diseases (CVDs). Transition metals, such as iron, zinc, copper and selenium, play a major role in cell metabolism. However, there is controversy over the effects of dietary and supplemental intake of these metals on cardiovascular risk factors and events. Since their pro-oxidant or antioxidant functions can have different effects on cardiovascular health...
December 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29235214/the-effect-of-administration-of-copper-nanoparticles-to-chickens-in-their-drinking-water-on-the-immune-and-antioxidant-status-of-the-blood
#11
Katarzyna Ognik, Iwona Sembratowicz, Ewelina Cholewińska, Jan Jankowski, Krzysztof Kozłowski, Jerzy Juśkiewicz, Zenon Zduńczyk
The aim of this experiment was to determine what dosage of copper (Cu) nanoparticles, added to a standard dietary supplementation with copper sulfate, would improve antioxidant and immune defense in chickens. The experiment was conducted with 126 broiler chickens assigned to seven treatments with three pens per treatment and six broiler chickens per pen. The basal-diet treatment did not receive Cu nanoparticles (nano-Cu) and as shown by analyses it was Cu-deficient (-29% vs. National Research Council (NRC) recommendations; 5...
December 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29228768/recovery-of-mrs3%C3%AE-mrs4%C3%AE-saccharomyces-cerevisiae-cells-under-iron-sufficient-conditions-and-the-role-of-fe580
#12
Michael J Moore, Joshua Wofford, Andrew Dancis, Paul Alan Lindahl
Mrs3 and Mrs4 are mitochondrial inner membrane proteins that deliver an unidentified cytosolic iron species into the matrix for use in iron-sulfur-cluster (ISC) and heme biosynthesis. The Mrs3/4 double-deletion strain (ΔΔ) grew slowly in iron-deficient glycerol/ethanol medium but recovered to WT rates in iron-sufficient medium. ΔΔ cells grown under both iron-deficient and iron-sufficient respiring conditions accumulated large amounts of iron relative to WT cells, indicating iron homeostatic dysregulation regardless of nutrient iron status...
December 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/29223451/mineralization-in-newborn-calves-contributes-to-health-improve-the-antioxidant-system-and-reduces-bacterial-infections
#13
Patrícia Glombowsky, Aleksandro S da Silva, Natan M Soldá, Gabriela M Galli, Angelisa H Biazus, Gabriela Campigotto, Nathieli B Bottari, Rejane S Sousa, Maiara C Brisola, Lenita M Stefani, Matheus D Baldissera, Marta L R Leal, Vera M Morsch, Maria Rosa C Schetinger, Gustavo Machado
The first phase of life of dairy calves has elevated mortality indices linked with low immunity and sanitary challenges, mainly bacterial infections are involved in the pathogenesis of diarrhea, the leading cause of death. Also, other important problem is the nutritional deficiencies, such as the mineral deficiency. Thus, the aim of this study was to evaluate whether an intramuscular mineral supplementation based on selenium, copper, potassium, magnesium and phosphorus possess beneficial effects on health of dairy calves...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29220735/regulation-of-sulfur-deprivation-induced-expression-of-the-ferredoxin-encoding-fdx5-gene-chlamydomonas-reinhardtii-in-aerobic-conditions
#14
Zhanneta Zalutskaya, Ekaterina Minaeva, Valentina Filina, Mariya Ostroukhova, Elena Ermilova
The unicellular green alga Chlamydomonas reinhardtii reacts to sulfur (S) starvation with the increased expression of numerous genes. One gene which is induced in illuminated anaerobic S-deprived cells is the ferredoxin-5 gene (FDX5). To test FDX5 transcriptional regulation in aerobic cultures, we used a real-time PCR analysis and an artificial microRNA approach. We demonstrated that FDX5 gene is controlled by S deprivation independently of anoxia-treatment. The Ser/Thr kinase SNRK2.1 is necessary for expression of FDX5 during deprivation to S...
December 2, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29217129/long-alimentary-limb-duodenal-switch-lads-a-short-term-prospective-randomized-trial
#15
Anabelle Cloutier, Stéfane Lebel, Frédéric Hould, François Julien, Simon Marceau, Léonie Bouvet, Serge Simard, Laurent Biertho
BACKGROUND: Biliopancreatic diversion with duodenal switch (BPD-DS) is one of the most effective bariatric surgeries, in terms of weight loss and remission of co-morbidities. It is however associated with a significant risk of protein and nutritional deficiency, as well as gastrointestinal side effects. OBJECTIVES: To assess the effect of increasing the strict alimentary limb on weight loss, nutritional deficiency and quality of life, compared with standard BPD-DS...
November 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29210524/tsc1-enables-plastid-development-under-dark-conditions-contributing-to-rice-adaptation-to-transplantation-shock
#16
Xiaoliang Shi, Sunlu Chen, Yu Peng, Yufeng Wang, Jiugeng Chen, Zhanghua Hu, Baohe Wang, Aihong Li, Daiyin Chao, Yuhong Li, Sheng Teng
Since its domestication from wild rice thousands of years ago, rice has been cultivated largely through transplantation. During transplantation from the nursery to the paddy field, rice seedlings experience transplantation shock which affects their physiology and production. However, the mechanisms underlying transplantation shock and rice adaptation to this shock are largely unknown. Here, we isolated a transplant-sensitive chloroplast-deficient (tsc1) rice mutant that produces albino leaves after transplantation...
December 6, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29207755/correlation-of-trace-elements-in-patients-of-chronic-liver-disease-with-respect-to-child-turcotte-pugh-scoring-system
#17
Amit Agarwal, Shilpa Avarebeel, Narendra S Choudhary, Mohan Goudar, C J Tejaswini
Introduction: Zinc, copper, manganese and magnesium are essential trace elements whose role in chronic liver disease and its complications is not clear. Aim: To study the concentration of these elements in patients with Chronic Liver Disease (CLD) with respect to Child-Torcotte-Pugh (CTP) scoring. Materials and Methods: This was an observational study carried out in the Department of Medicine, JSS Hospital, Mysore, India, between October 2013 and October 2015...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29203265/a-low-blood-copper-concentration-is-a-co-morbidity-burden-factor-in-parkinson-s-disease-development
#18
Ekaterina Y Ilyechova, Iren V Miliukhina, Iurii A Orlov, Zamira M Muruzheva, Ludmila V Puchkova, Marina N Karpenko
Parkinson's disease (PD) patients are often characterized by copper dyshomeostasis, which is responsible for ROS formation and fibrillogenesis. However, the relationships between copper metabolism and PD development are unclear. In this study in 50 patients with PD (pPD) and 50 age-matched healthy individuals, the serum total copper concentration, oxidase activity, ceruloplasmin and SOD3 protein concentrations were measured; and amount of copper atoms per ceruloplasmin molecule was calculated. These parameters were lower in pPD relatively to healthy volunteers...
December 1, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29200268/design-of-a-photoredox-catalyst-that-enables-the-direct-synthesis-of-carbamate-protected-primary-amines-via-photoinduced-copper-catalyzed-n-alkylation-reactions-of-unactivated-secondary-halides
#19
Jun Myun Ahn, Jonas C Peters, Gregory C Fu
Despite the long history of SN2 reactions between nitrogen nucleophiles and alkyl electrophiles, many such substitution reactions remain out of reach. In recent years, efforts to develop transition-metal catalysts to address this deficiency have begun to emerge. In this report, we address the challenge of coupling a carbamate nucleophile with an unactivated secondary alkyl electrophile to generate a substituted carbamate, a process that has not been achieved effectively in the absence of a catalyst; the product carbamates can serve as useful intermediates in organic synthesis as well as bioactive compounds in their own right...
December 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29194641/chemometric-analysis-of-minerals-in-gluten-free-products
#20
Anna Gliszczyńska-Świgło, Inga Klimczak, Iga Rybicka
BACKGROUND: Numerous studies indicate mineral deficiencies in people on a gluten-free (GF) diet. These deficiencies may indicate that GF products are less valuable source of minerals than gluten-containing products. In the study, the nutritional quality of fifty GF products is discussed taking into account the nutritional requirements for minerals expressed as % Recommended Daily Allowance (%RDA) or % Adequate Intake (%AI) for a model celiac patient. Analysed elements were: calcium, potassium, magnesium, sodium, copper, iron, manganese, and zinc...
November 30, 2017: Journal of the Science of Food and Agriculture
keyword
keyword
59374
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"