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Copper deficiency

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https://www.readbyqxmd.com/read/27895622/serum-zn-cu-ratio-is-associated-with-renal-function-glycemic-control-and-metabolic-parameters-in-japanese-patients-with-and-without-type-2-diabetes-a-cross-sectional-study
#1
Hidetaka Hamasaki, Yu Kawashima, Hidekatsu Yanai
BACKGROUND: Zinc (Zn) and copper (Cu) may play a pivotal role in the pathogenesis of diabetes and diabetic complications by mediating oxidative stress. Both Zn deficiency and excess of Cu are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to investigate the relationships between serum Zn/Cu ratio and glycemic status, renal function, and metabolic parameters in patients with and without type 2 diabetes. METHODS: We conducted a cross-sectional study on 355 subjects (149 type 2 diabetic and 206 non-diabetic) in whom serum Zn and Cu levels were measured at the same time...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27889885/investigating-factors-involved-in-post-laparoscopic-sleeve-gastrectomy-lsg-neuropathy
#2
Almaha Alsabah, Salman Al Sabah, Suleiman Al-Sabah, Ahmad Al-Serri, Eliana Al Haddad, Waleed M Renno
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity as the leading bariatric procedure for the treatment of morbid obesity. Due to the rising numbers of bariatric surgeries, neurologic complications have become increasingly recognized. Our aim was to examine biochemical and hormonal factors that are associated with neuropathy post-LSG. METHODS: Thirty-two patients were included: 16 patients with neuropathy in the neuropathic group (NG) and 16 patients without neuropathy in the control group (CG)...
November 26, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27881675/the-intestinal-copper-exporter-cua-1-is-required-for-systemic-copper-homeostasis-in-caenorhabditis-elegans
#3
Haarin Chun, Anuj Kumar Sharma, Jaekwon Lee, Jefferson Chan, Shang Jia, Byung-Eun Kim
Copper (Cu) plays key catalytic and regulatory roles in biochemical processes essential for normal growth, development, and health. Defects in Cu metabolism cause Menkes and Wilson's disease, myeloneuropathy, and cardiovascular disease and are associated with other pathophysiological states. Consequently, it is critical to understand the mechanisms by which organisms control the acquisition, distribution, and utilization of Cu. The intestinal enterocyte is a key regulatory point for Cu absorption into the body, however the mechanisms by which intestinal cells transport Cu to maintain organismal Cu homeostasis are poorly understood...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27853789/chemical-and-functional-properties-of-metal-chelators-that-mobilize-copper-to-elicit-fungal-killing-of-cryptococcus-neoformans
#4
Marian E Helsel, Elizabeth J White, Sayyeda Zeenat A Razvi, Bruno Alies, Katherine J Franz
A panel of iron (Fe) and copper (Cu) chelators was screened for growth inhibitory activity against the fungal pathogen Cryptococcus neoformans. Select bidentate metal-binding ligands containing mixed O,S or O,N donor atoms were identified as agents that induce cell killing in a Cu-dependent manner. Conversely, structurally similar ligands with O,O donor atoms did not inhibit C. neoformans growth regardless of Cu status. Studies of Cu(ii) and Cu(i) binding affinity, lipophilicity, and growth recovery assays of Cu-import deficient cells identified lipophilicity of thermodynamically stable Cu(II)L2 complexes as the best predictor of antifungal activity...
November 17, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27830552/demonstrating-potential-of-cell-therapy-for-wilson-s-disease-with-the-long-evans-cinnamon-rat-model
#5
Fadi Luc Jaber, Yogeshwar Sharma, Sanjeev Gupta
Wilson's disease (WD) is characterized by the inability to excrete copper (Cu) from the body with progressive tissue injury, especially in liver and brain. The molecular defect in WD concerns mutations in ATP7B gene leading to loss of Cu transport from the hepatocyte to the bile canaliculus. While drugs, e.g., Cu chelators, have been available for several decades, these must be taken lifelong, which can be difficult due to issues of compliance or side effects. Many individuals may require liver transplantation, which can also be difficult due to donor organ shortages...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27817091/is-aceruloplasminemia-treatable-combining-iron-chelation-and-fresh-frozen-plasma-treatment
#6
L Poli, A Alberici, P Buzzi, E Marchina, A Lanari, C Arosio, A Ciccone, F Semeraro, R Gasparotti, A Padovani, Barbara Borroni
We report the case of a patient with hereditary ceruloplasmin deficiency due to a novel gene mutation in ceruloplasmin gene (CP), treated with fresh frozen plasma (FFP) and iron chelation therapy. A 59-year-old man with a past history of diabetes was admitted to our department due to progressive gait difficulties and cognitive impairment. Neurological examination revealed a moderate cognitive decline, with mild extrapyramidal symptoms, ataxia, and myoclonus. Brain T2-weighted MR imaging showed bilateral basal ganglia hypointensity with diffuse iron deposition...
November 5, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27799013/ecotoxicological-assessment-of-dewatered-drinking-water-treatment-residue-for-environmental-recycling
#7
Nannan Yuan, Changhui Wang, Laura A Wendling, Yuansheng Pei
Drinking water treatment residue (DWTR) is commonly regarded as a waste product of drinking water treatment plant, which is disposed to sewer or to landfill, with associated financial and environmental costs. Fortunately, the beneficial recycle of DWTR in environmental remediation has been demonstrated in many reports. However, the lack of information concerning the potential toxicity of dewatered DWTR hinders its widespread use in environmental applications. The present study examined the ecotoxicity of dewatered aluminum (Al) and iron (Fe) DWTR leachates to a green alga, Chlorella vulgaris, systematically...
October 31, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27788057/low-copper-levels-associated-with-low-carcass-weight-in-wild-red-deer-cervus-elaphus-in-norway
#8
Kjell Handeland, Hildegunn Viljugrein, Syverin Lierhagen, Marthe Opland, Attila Tarpai, Turid Vikøren
Copper (Cu) deficiency is associated with several disease syndromes, including poor growth, in farmed red deer ( Cervus elaphus ), but little is known of the consequences of low Cu levels in free-ranging populations. Low hepatic Cu levels have been documented in several wild red deer populations along the west coast of Norway, with the lowest values found on the island of Hitra. We studied the relationship between liver Cu concentration and slaughter weight in 63 red deer calves and 69 yearlings shot on Hitra during the autumn hunting season of 2009...
October 27, 2016: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27773706/synthesis-biological-characterization-and-evaluation-of-molecular-mechanisms-of-novel-copper-complexes-as-anticancer-agents
#9
Ceyda Acilan, Zelal Adiguzel, Buse Cevatemre, Didem Karakas, Engin Ulukaya, Nádia Ribeiro, Isabel Correia, João Costa Pessoa
BACKGROUND: To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based compounds. Here, three Cu(II)-complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)(pheamine), Cu(Sal-Gly)(phepoxy) are characterized for their interaction with DNA, cytotoxicity and mechanism of action. METHODS: The binding ability of the complexes to Calf-Thymus DNA was evaluated by competition fluorescence studies with thiazole-orange, UV-Vis and circular-dichroism spectroscopic titrations...
October 20, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27767213/the-copper-micrornas
#10
Marinus Pilon
I. II. III. IV. V. VI. VII. VIII. References SUMMARY: Copper (Cu) microRNAs are upregulated by Cu deficiency and mediate the post-transcriptional downregulation of transcripts that encode Cu proteins, suggesting a role directly related to Cu. However, expression and phenotypic analyses of copper microRNA mutants and over-expressors have suggested roles mainly in tolerance to abiotic stresses. To reconcile available data, a model is proposed which emphasizes the mobile nature of copper microRNA molecules in the regulation of Cu homeostasis...
October 21, 2016: New Phytologist
https://www.readbyqxmd.com/read/27748300/homocysteine-its-metabolite-homocysteine-thiolactone-deficiency-of-copper-in-patients-with-age-related-macular-degeneration-a-pilot-study
#11
Muthuvel Bharathselvi, Sayantan Biswas, Rajiv Raman, Radhakrishnan Selvi, Karunakaran Coral, Angayarkanni Narayanansamy, Sivaramakrishnan Ramakrishnan, Konerirajapuram N Sulochana
BACKGROUND & OBJECTIVES: Age related macular degeneration (ARMD) is a leading cause of blindness, particularly in persons above 60 yr of age. Homocysteine is implicated in many ocular diseases including ARMD. This study was undertaken to assess the status and relationship between plasma homocysteine, homocysteine - thiolactone, homocysteinylated protein and copper levels in patients with ARMD. METHODS: A total of 16 patients with ARMD and 16 age-matched controls were recruited for the study...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27733860/association-of-increased-grain-iron-and-zinc-concentrations-with-agro-morphological-traits-of-biofortified-rice
#12
Laura T Moreno-Moyano, Julien P Bonneau, José T Sánchez-Palacios, Joseph Tohme, Alexander A T Johnson
Biofortification of rice (Oryza sativa L.) with micronutrients is widely recognized as a sustainable strategy to alleviate human iron (Fe) and zinc (Zn) deficiencies in developing countries where rice is the staple food. Constitutive overexpression of the rice nicotianamine synthase (OsNAS) genes has been successfully implemented to increase Fe and Zn concentrations in unpolished and polished rice grain. Intensive research is now needed to couple this high-micronutrient trait with high grain yields. We investigated associations of increased grain Fe and Zn concentrations with agro-morphological traits of backcross twice second filial (BC2F2) transgenic progeny carrying OsNAS1 or OsNAS2 overexpression constructs under indica/japonica and japonica/japonica genetic backgrounds...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27718581/copper-mediated-radiofluorination-of-arylstannanes-with-18-f-kf
#13
Katarina J Makaravage, Allen F Brooks, Andrew V Mossine, Melanie S Sanford, Peter J H Scott
A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [(18)F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers including protected [(18)F]F-phenylalanine and [(18)F]F-DOPA. In addition, an automated synthesis of [(18)F]MPPF is demonstrated that delivers a clinically validated dose of 200 ± 20 mCi with a high specific activity of 2400 ± 900 Ci/mmol...
October 10, 2016: Organic Letters
https://www.readbyqxmd.com/read/27682263/bioavailable-trace-metals-in-neurological-diseases
#14
REVIEW
Aurélia Poujois, Jean-Christophe Devedjian, Caroline Moreau, David Devos, Pascal Chaine, France Woimant, James A Duce
Medical treatment in Wilson's disease includes chelators (D-penicillamine and trientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorised into two phases; the first being a de-coppering phase and the second a maintenance one. The best therapeutic approach remains controversial, as only a few non-controlled trials have compared these treatments. During the initial phase, progressive increase of chelators' doses adjusted to exchangeable copper and urinary copper might help to avoid neurological deterioration...
October 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27672992/poster-234-cocaine-induced-spinal-cord-infarct-in-a-patient-with-copper-and-zinc-deficiencies-a-case-report
#15
Mark Bauernfeind, Kristen M Brusky, Jean L Nickels
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27648664/enantioselective-cyclopropanation-of-a-wide-variety-of-olefins-catalyzed-by-ru-ii-pheox-complexes
#16
Soda Chanthamath, Seiji Iwasa
The transition-metal-catalyzed asymmetric cyclopropanation of olefins with diazoacetates has become one of the most important methods for the synthesis of optically active cyclopropane derivatives, which are key pharmaceutical building blocks and present in a large number of natural products. To date, significant progress has been made in this area of research, and efficient stereocontrolled synthetic approaches to cyclopropane derivatives have been developed using rhodium, ruthenium, copper, and cobalt catalysts...
October 18, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27645757/copper-deficiency-myelopathy-probably-caused-by-long-lasting-daily-excessive-intake-of-zink
#17
Rieko Motooka, Shinji Yamamoto
We report a 39-year-old woman with slowly progressive spastic gait and paresthesia in the lower extremities. Cervical spinal MRI revealed high intensity in the dorsal column from vertebrae C2 to C7. Laboratory findings showed normal vitamin B12 and low serum copper level. By lifestyle history taking, we noticed her extreme unbalanced diet of having 15-20 oysters everyday over 5 years. Then we considered that zinc excess caused copper deficiency myelopathy. We needed to pay attention to copper and zinc level if the patient has a symptom resembling subacute combined degeneration of spinal cord with normal serum vitamin B12...
September 16, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27640333/dietary-vitamin-c-deficiency-depressed-the-gill-physical-barriers-and-immune-barriers-referring-to-nrf2-apoptosis-mlck-nf-%C3%AE%C2%BAb-and-tor-signaling-in-grass-carp-ctenopharyngodon-idella-under-infection-of-flavobacterium-columnare
#18
Hui-Jun Xu, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study explored the effects of vitamin C on the physical barriers and immune barriers, and relative mRNA levels of signaling molecules in the gill of grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare. The results indicated that compared with optimal vitamin C supplementation, vitamin C deficiency (2.9 mg/kg diet) (1) increased reactive oxygen species, malondialdehyde and protein carbonyl (PC) contents (P < 0.05), decreased the copper/zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and mRNA levels (P < 0...
September 15, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27635061/copper-deficiency-as-a-cause-of-neutropenia-in-a-case-of-coeliac-disease
#19
Daisy Khera, Baldev Sharma, Kuldeep Singh
We report a 17 year-old male patient, who presented with chronic diarrhoea, progressive pallor, short stature, anaemia (haemoglobin of 4.9 g/dL) and neutropenia and was diagnosed as coeliac disease. His neutropenia did not respond to 8 months of gluten-free diet, iron, folic acid and vitamin B12 therapy. So we suspected copper deficiency and his serum copper levels were tested, which was low. His neutrophil counts normalised after 2 months of copper supplementation. Hence we concluded that the cause of neutropenia in our case was copper deficiency...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27631241/recurrent-spontaneous-subserosal-hematoma-of-ileum-causing-intestinal-obstruction-in-a-patient-with-menkes-disease-a-case-report
#20
Shu-Chao Weng, Chyong-Hsin Hsu, Nien-Lu Wang, Shuan-Pei Lin, Chuen-Bin Jiang
BACKGROUND: Menkes disease (MD) is a disorder of copper metabolism due to ATP7A gene mutation that leads to severe copper deficiency. Deformed blood vessels can be found in many parts of the body, and intracranial hematoma is generally reported. METHODS: We report a Taiwanese boy with MD who had recurrent spontaneous subserosal hematoma of ileum presenting as intestinal obstruction, with the 2 episodes 23 months apart. The patient returned to the usual physical status after surgical removal of the hematoma...
September 2016: Medicine (Baltimore)
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