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Copper deficiency

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https://www.readbyqxmd.com/read/28815023/antibiotic-resistance-ability-to-form-biofilm-and-susceptibility-to-copper-alloys-of-selected-staphylococcal-strains-isolated-from-touch-surfaces-in-polish-hospital-wards
#1
Anna Różańska, Agnieszka Chmielarczyk, Dorota Romaniszyn, Małgorzata Bulanda, Monika Walkowicz, Piotr Osuch, Tadeusz Knych
BACKGROUND: Despite the employment of sanitary regimes, contact transmission of the aetiological agents of hospital infections is still exceedingly common. The issue of microbe transmission becomes particularly important when facing multidrug-resistant microorganisms such as methicillin-resistant staphylococci. In the case of deficiencies in cleaning and disinfection procedures, hospital equipment made of copper alloys can play an important role, complementing traditional hospital hygiene procedures...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28811809/peppered-and-rare-gastric-and-duodenal-pseudomelanosis-a-case-series
#2
Sami Samiullah, Hadi Bhurgri, Arooj Babar, Fatima Samad, Moaz M Choudhary, Michael Demyen
Upper Gastrointestinal (GI) pseudomelanosis is an uncommon entity characterized by endoscopic visualization of speckled dark mucosal pigmentation. While described in the rectum and colon, 'melanosis' or more aptly 'pseudomelanosis' is rare in the duodenum and exceedingly rare in the stomach. Five cases of pseudomelanosis were encountered at our department. Four females and one male were diagnosed, with a mean age of 70 years. All patients exhibited duodenal pseudomelanosis, with one demonstrating gastric antral pseudomelanosis as well...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811697/role-of-iron-and-copper-in-the-pathogenesis-of-parkinson-s-disease
#3
Mohit Kumar Gangania, Jyoti Batra, Suman Kushwaha, Rachna Agarwal
Parkinson's disease (PD) is an old age disorder of basal ganglia which involves oligomerization of α-synuclein protein and formation of intercellular inclusions known as "Lewy bodies" in substantia nigra and caudate nuclei in brain which is progressive in nature. It is second most prevalent neurodegenerative disorder characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes in posture (instability). Both excess and deficiency in levels of transition metals (especially iron, copper) can be detrimental to the central nervous system...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28801722/effect-of-disturbances-of-zinc-and-copper-on-the-physical-and-mental-health-status-of-patients-with-alcohol-dependence
#4
M Ordak, E Bulska, K Jablonka-Salach, A Luciuk, M Maj-Żurawska, H Matsumoto, T Nasierowski, M Wojnar, J Matras, E Muszynska, M Bujalska-Zadrozny
The concentrations of copper and zinc in the tissues of alcohol-addicted people can significantly correlate with the variables describing their mental state. Studies on the homeostasis of zinc in alcohol-dependent patients have often been characterized by low hypozincemia detection. This may be caused by a low content of zinc in blood serum (1%) compared to the average zinc level in the body. Unfortunately, most authors have identified extracellular zinc in their studies. In the available literature, data on the level of copper in patients suffering from alcohol dependence are inconsistent...
August 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28799141/trace-element-and-vitamin-concentrations-in-paediatric-dialysis-patients
#5
Triona Joyce, Frances Court Brown, Dean Wallace, Christopher J D Reid, Manish D Sinha
BACKGROUND: There are few recent data regarding blood micronutrient concentrations and supplementation in children on maintenance dialysis. We investigated micronutrient concentrations following dialysis commencement. METHODS: Retrospective review, including all children on maintenance dialysis (peritoneal dialysis, PD; intermittent haemodialysis, IHD), for nutritional blood concentrations measured over the first 12 months. Patients received pyridoxine and Dialyvit® daily with planned 3-monthly micronutrient concentration monitoring including selenium, manganese, copper, zinc, folate and vitamins A, D, B12 and E...
August 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28797164/universal-surface-engineering-of-transition-metals-for-superior-electrocatalytic-hydrogen-evolution-in-neutral-water
#6
Bo You, Xuan Liu, Guoxiang Hu, Sheraz Gul, Junko Yano, De-En Jiang, Yujie Sun
The development of low-cost hybrid water splitting-biosynthetic systems that mimic natural photosynthesis to achieve solar-to-chemical conversion is of great promise for future energy demands, but often limited by the kinetically sluggish H2 evolu-tion reaction (HER) on the surface of nonprecious transition metal catalysts in neutral media. It is thus highly desirable to rationally tailor the reaction interface to boost the neutral HER catalytic kinetics. Herein, we report a general surface nitro-gen modification of diverse transition metals (e...
August 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28790120/zinc-containing-dental-fixative-causing-copper-deficiency-myelopathy
#7
Liam Stuart Carroll, Azmil H Abdul-Rahim, Rosanne Murray
A 62-year-old male, previously well, was referred to neurology clinic following 6 months history of worsening lower limbs instability, paraesthesia, pain and weakness rendering him housebound. Examination revealed upper motor neuron pattern of weakness of the lower limbs and loss of proprioception. Serum analysis revealed reduced caeruloplasmin and copper levels with raised zinc. Spinal imaging revealed subtle dorsal column intensity changes in C2-C7, confirmed with 3T MRI. A copper deficiency myeloneuropathy was diagnosed secondary to chronic use of a zinc-containing dental fixative paste...
August 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28780535/clinical-physiological-and-pathological-characterisation-of-the-sensory-predominant-peripheral-neuropathy-in-copper-deficiency
#8
Sean W Taylor, Ruple S Laughlin, Neeraj Kumar, Brent Goodman, Christopher J Klein, Peter J Dyck, P James B Dyck
INTRODUCTION: Myelopathy is considered the most common neurological complication of copper deficiency. Concurrent peripheral neuropathy has been recognised in association with copper deficiency but has not been well characterised. OBJECTIVES: To characterise the clinical, physiological and pathological features of copper-deficient peripheral neuropathy. METHODS: Patients with simultaneous copper deficiency (<0.78 μg/mL) and peripheral neuropathy seen at the Mayo Clinic from 1985 to 2005 were identified...
August 5, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28759019/copper-import-in-escherichia-coli-by-the-yersiniabactin-metallophore-system
#9
Eun-Ik Koh, Anne E Robinson, Nilantha Bandara, Buck E Rogers, Jeffrey P Henderson
Copper plays a dual role as a nutrient and a toxin during bacterial infections. While uropathogenic Escherichia coli (UPEC) strains can use the copper-binding metallophore yersiniabactin (Ybt) to resist copper toxicity, Ybt also converts bioavailable copper to Cu(II)-Ybt in low-copper conditions. Although E. coli have long been considered to lack a copper import pathway, we observed Ybt-mediated copper import in UPEC using canonical Fe(III)-Ybt transport proteins. UPEC removed copper from Cu(II)-Ybt with subsequent re-export of metal-free Ybt to the extracellular space...
September 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28756600/trace-metals-in-the-urine-and-hair-of-a-population-in-an-endemic-arsenism-area
#10
Binggan Wei, Jiangping Yu, Jing Wang, Hairong Li, Linsheng Yang, Chang Kong
There have been few investigations of trace elements in the urine and hair of populations exposed to high levels of arsenic (As) in drinking water. Therefore, concentrations of selected metals in urine and hair samples from a population in a study area where arsenism was endemic and a control area were determined. It was found that the median concentrations of barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), zinc (Zn), and As in the urine samples from the population in the study area were 3...
July 29, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28754902/effect-of-sodium-treatment-on-the-performance-of-electrostatic-spray-assisted-vapour-deposited-copper-poor-cu-in-ga-s-se-2-solar-cells
#11
Mingqing Wang, Md Anower Hossain, Kwang-Leong Choy
In our work, eco-friendly, non-vacuum and low cost Electrostatic Spray Assisted Vapour Deposition (ESAVD) method has been used to produce Cu(In,Ga)(S,Se)2 (CIGS) solar cells. Copper (Cu) deficient (Cu/In + Ga = 0.76) CIGS films were designed to avoid the rather dangerous KCN treatment step for the removal of conductive minor phases of Cu2S/Cu2Se. A simple sodium (Na) treatment method was used to modify the morphology and electronic properties of the absorber and it clearly improved the solar cell performance...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727945/micronutrient-alterations-during-continuous-renal-replacement-therapy-in-critically-ill-adults-a-retrospective-study
#12
Amir Y Kamel, Nisha J Dave, Vivian M Zhao, Daniel P Griffith, Michael J Connor, Thomas R Ziegler
BACKGROUND: Continuous renal replacement therapy (CRRT) is commonly used to provide renal replacement therapy in the intensive care unit. Limited published data suggest that CRRT may lead to depletion of water-soluble vitamins and trace elements. The goal of this study was to identify the incidence of trace element and vitamin deficiencies in critically ill patients during CRRT. MATERIALS AND METHODS: This study is based on a retrospective chart review of patients who were referred to Emory University Hospital's nutrition support services and had at least 1 serum micronutrient level measured during CRRT (thiamin, pyridoxine, ascorbic acid, folate, zinc, and copper) between April 1, 2009, and June 1, 2012...
July 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28718091/nutritional-and-micronutrient-care-of-bariatric-surgery-patients-current-evidence-update
#13
REVIEW
Michael A Via, Jeffrey I Mechanick
PURPOSE OF REVIEW: The continued success of bariatric surgery to treat obesity and obesity-associated metabolic conditions creates a need for a strong understanding of clinical nutrition both before and after these procedures. RECENT FINDINGS: Surgically induced alteration of gastrointestinal physiology can affect the nutrition of individuals, especially among those who have undergone malabsorptive procedures. While uncommon, a subset of patients may develop protein-calorie malnutrition...
July 17, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28710591/effect-of-dietary-phytase-supplementation-on-bone-and-hyaline-cartilage-development-of-broilers-fed-with-organically-complexed-copper-in-a-cu-deficient-diet
#14
Siemowit Muszyński, Ewa Tomaszewska, Małgorzata Kwiecień, Piotr Dobrowolski, Agnieszka Tomczyk
Tibial mechanical, chemical, and histomorphometrical traits were investigated for growing male Ross 308 broiler chickens fed diets that had copper (Cu) from organic source at a lowered level of 25% of the daily requirement (4 mg kg(-1) of a premix) with or without phytase. Dietary treatments were control non-copper, non-phytase group (0 Suppl); 4 mg kg(-1) Cu non-phytase group (25%Cu); and 4 mg kg(-1) Cu + 500 FTU kg(-1) phytase group (25%Cu + phyt). The results show that birds fed with the addition of phytase exhibited improved weight gain and final body weight and had increased serum IGF-1 and osteocalcin concentrations...
July 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28693861/supplementation-with-zinc-in-rats-enhances-memory-and-reverses-an-age-dependent-increase-in-plasma-copper
#15
Leslie A Sandusky-Beltran, Bryce L Manchester, Ewan C McNay
Zinc and copper are essential trace elements. Dyshomeostasis in these two metals has been observed in Alzheimer's disease, which causes profound cognitive impairment. Insulin therapy has been shown to enhance cognitive performance; however, recent data suggest that this effect may be at least in part due to the inclusion of zinc in the insulin formulation used. Zinc plays a key role in regulation of neuronal glutamate signaling, suggesting a possible link between zinc and memory processes. Consistent with this, zinc deficiency causes cognitive impairments in children...
July 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28684721/drosophila-melanogaster-models-of-metal-related-human-diseases-and-metal-toxicity
#16
REVIEW
Pablo Calap-Quintana, Javier González-Fernández, Noelia Sebastiá-Ortega, José Vicente Llorens, María Dolores Moltó
Iron, copper and zinc are transition metals essential for life because they are required in a multitude of biological processes. Organisms have evolved to acquire metals from nutrition and to maintain adequate levels of each metal to avoid damaging effects associated with its deficiency, excess or misplacement. Interestingly, the main components of metal homeostatic pathways are conserved, with many orthologues of the human metal-related genes having been identified and characterized in Drosophila melanogaster...
July 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28681556/the-influence-of-light-on-copper-limited-growth-of-an-oceanic-diatom-thalassiosira-oceanica-coscinodiscophyceae
#17
Jun-Woo Kim, Neil M Price
Thalassiosira oceanica (CCMP 1005) was grown over a range of copper concentrations at saturating and sub-saturating irradiance to test the hypothesis that Cu and light were interacting essential resources. Growth was a hyperbolic function of irradiance in Cu-replete medium (263 fmol Cu' · L(-1) ) with maximum rates achieved at 200 μmol photons · m(-2) · s(-1) . Lowering the Cu concentration at this irradiance to 30.8 fmol Cu' · L(-1) decreased cellular Cu quota by 7-fold and reduced growth rate by 50%...
July 6, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28659010/copper-deficiency-myelopathy-after-upper-gastrointestinal-surgery
#18
Dominic King, Keith Siau, Latha Senthil, Katherine F Kane, Sheldon C Cooper
A well-functioning alimentary canal is required for adequate nutrient absorption. Disruption to the upper gastrointestinal tract through surgery can lead to micronutrient malnourishment. Copper deficiency has been noted in up to 10% of those undergoing Roux-en-Y gastric bypass surgery, but sequalae are not frequently reported. The resultant deficiency states can have profound and long-term consequences if not realized early and managed appropriately. Here we present a case of copper deficiency myelopathy, a condition indistinguishable from subacute combined degeneration of the spinal cord, following upper gastrointestinal bypass surgery for gastric ulceration, further complicated by inadequate nutrition...
June 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28655353/xc_0531-encodes-a-c-type-cytochrome-biogenesis-protein-and-is-required-for-pathogenesis-in-xanthomonas-campestris-pv-campestris
#19
Lei Chen, Mingpeng Wang, Li Huang, Zhaojie Zhang, Fanghua Liu, Guangtao Lu
BACKGROUND: The phytopathogenic Xanthomonas campestris pv.campestris is a gram-negative bacterium and the causal agent of black-rot disease of cruciferous crops. Many gram-negative bacteria possess a family of proteins, called Dsbs, which are involved in disulfide bond formation in certain periplasmic proteins. In our preliminary screening of the virulence to the plants we identified that gene XC_0531 which annotated gene dsbD of Xanthomonas campestris pv. campestris (Xcc) is related to the virulence to the host plants...
June 27, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28654115/evidence-for-widespread-severe-brain-copper-deficiency-in-alzheimer-s-dementia
#20
Jingshu Xu, Stephanie J Church, Stefano Patassini, Paul Begley, Henry J Waldvogel, Maurice A Curtis, Richard L M Faull, Richard D Unwin, Garth J S Cooper
Datasets comprising simultaneous measurements of many essential metals in Alzheimer's disease (AD) brain are sparse, and available studies are not entirely in agreement. To further elucidate this matter, we employed inductively-coupled-plasma mass spectrometry to measure post-mortem levels of 8 essential metals and selenium, in 7 brain regions from 9 cases with AD (neuropathological severity Braak IV-VI), and 13 controls who had normal ante-mortem mental function and no evidence of brain disease. Of the regions studied, three undergo severe neuronal damage in AD (hippocampus, entorhinal cortex and middle-temporal gyrus); three are less-severely affected (sensory cortex, motor cortex and cingulate gyrus); and one (cerebellum) is relatively spared...
August 16, 2017: Metallomics: Integrated Biometal Science
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