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https://www.readbyqxmd.com/read/29161786/oral-submucous-fibrosis-an-etiological-dilemma
#1
Aanchal Sharma, Rajesh Kumar, Navdeep Johar, Husain Sabir
Oral Submucous Fibrosis (OSF), is a well-recognized, oral potentially malignant disorder predominantly affecting the South- Asian countries. OSF causes unique generalized fibrosis of the submucosal oral soft tissues, resulting in marked rigidity of the oral mucosa leading to progressive inability to open the mouth, rigidity of lips and difficulty in protruding the tongue. In this review we have discussed the multifactorial etiology of this potentially malignant disorder, including Chillies, Nutritional Deficiencies, Inducible nitric oxide synthsis (iNOS), genetic and immunological predisposition; and most importantly the role of areca nut and the effect of copper content in it...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29154507/relationship-between-selected-micronutrient-deficiencies-and-oxidative-stress-biomarkers-in-diabetes-mellitus-patients-with-foot-ulcers-in-ibadan-nigeria
#2
Elizabeth Bosede Bolajoko, Olubayo Michael Akınosun, John Anetor, Kensese Sontin Mossanda
Background/aim: Micronutrients are indispensable in the prevention of diseases and maintenance of good health. Their deficiencies have been implicated in several diseases associated with oxidative stress (OS). This study aimed at investigating the levels of some vitamins and minerals in association with OS markers in diabetic foot ulcer (DFU) patients in Ibadan, Oyo State, Nigeria. Materials and methods: Seventy DFU patients and 50 apparently healthy volunteers (controls) were recruited for the study. Blood samples of 10 mL were collected after a 10-h overnight fast from each participant after obtaining their consent...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29147017/oxidation-behavior-of-graphene-coated-copper-at-intrinsic-graphene-defects-of-different-origins
#3
Jinsung Kwak, Yongsu Jo, Soon-Dong Park, Na Yeon Kim, Se-Yang Kim, Hyung-Joon Shin, Zonghoon Lee, Sung Youb Kim, Soon-Yong Kwon
The development of ultrathin barrier films is vital to the advanced semiconductor industry. Graphene appears to hold promise as a protective coating; however, the polycrystalline and defective nature of engineered graphene hinders its practical applications. Here, we investigate the oxidation behavior of graphene-coated Cu foils at intrinsic graphene defects of different origins. Macro-scale information regarding the spatial distribution and oxidation resistance of various graphene defects is readily obtained using optical and electron microscopies after the hot-plate annealing...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29140714/copper-catalyzed-dehydrogenative-formal-4-2-and-3-2-cycloadditions-of-methylnaphthalenes-and-electron-deficient-alkenes
#4
Guiping Qin, Yong Wang, Hanmin Huang
Higher π-extended naphthalene, contained in methylnaphthalenes, which could capture alkyl radicals via SOMO-LUMO interactions, enabled the development of Cu-catalyzed formal [4 + 2] and [3 + 2] cycloadditions between methylnaphthalenes and electron-deficient alkenes. Under copper catalysis, a series of electron-deficient alkenes and methylnaphthalenes with different substituents were successfully incorporated with di-tert-butyl peroxide (TBP) as an oxidant and radical initiator, providing a wide range of cycloadducts...
November 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/29128810/effect-of-dietary-copper-nanoparticles-versus-one-copper-ii-salt-analysis-of-vasoreactivity-in-a-rat-model
#5
Michal Majewski, Katarzyna Ognik, Przemyslaw Zdunczyk, Jerzy Juskiewicz
BACKGROUND: Vascular defects in the mechanical properties of aorta and muscular arteries have been previously reported in animals with copper-deficient feed. However, the interaction between copper nanoparticles (CuNPs) and mechanical properties of arteries has not been reported. Hence, the present study was aimed to evaluate the effect of copper nanoparticles on the vasoreactivity of rat isolated thoracic arteries. METHODS: In this study, 5 week old male Wistar rats were fed a copper-adequate diet (CuA, 6...
June 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29114147/malaria-induced-anaemia-and-serum-micronutrients-in-asymptomatic-plasmodium-falciparum-infected-patients
#6
Babamale O Abdulkareem, Abdulkareem O Adam, Akande O Ahmed, Afolayan A Mariam, Ugbomoiko U Samuel
Interaction between malaria, anaemia and malnutrition is poorly understood in asymptomatic malaria patients. This information is important in the management of malaria infection in many endemic regions in sub-Saharan Africa. Malaria parasitaemia, full blood counts and serum levels of essential micronutrients particularly iron (Fe), zinc (Zn) and copper (Cu) of the patients attending Health Centres in Ilorin, Kwara state were investigated using microscope, auto-haemanalyzer and atomic absorption spectrophotometer respectively...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29114014/arabidopsis-pollen-fertility-requires-the-transcription-factors-citf1-and-spl7-that-regulate-copper-delivery-to-anthers-and-jasmonic-acid-synthesis
#7
Jiapei Yan, Ju-Chen Chia, Huajin Sheng, Ha-Il Jung, Tetiana-Olena Zavodna, Zhang Lu, Rong Huang, Chen Jiao, Eric Craft, Zhangjun Fei, Leon Vincent Kochian, Olena K Vatamaniuk
A deficiency of the micronutrient copper (Cu) leads to infertility and grain/seed yield reduction in plants. How Cu affects fertility, which reproductive structures require Cu, and which transcriptional networks coordinate Cu delivery to reproductive organs is poorly understood. Using RNA-seq analysis, we showed that the expression of a gene encoding a novel transcription factor, CITF1 (Cu-deficiency Induced Transcription Factor 1), was strongly upregulated in Arabidopsis thaliana flowers subjected to Cu deficiency...
November 7, 2017: Plant Cell
https://www.readbyqxmd.com/read/29112279/nutrients-intake-and-serum-calcium-and-phosphorus-levels-an%C3%A2-evidence-based-study
#8
Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A Ferns, Majid Ghayour Mobarhan
INTRODUCTION: Dietary calcium and phosphorus appear to be important determinants of dyslipidemia and hypertension. We have investigated (1) the prevalence of hypocalcemia and hypophosphatemia in an Iranian population, and (2) the association between nutrient's intake and serum levels of calcium and phosphorus. METHODS: A total of 908 individuals were enrolled using a stratified-cluster sampling method from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) study...
November 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29112116/application-of-chitosan-chitooligosaccharide-and-their-derivatives-in-the-treatment-of-alzheimer-s-disease
#9
REVIEW
Qian-Qian Ouyang, Shannon Zhao, Si-Dong Li, Cai Song
Classic hypotheses of Alzheimer's disease (AD) include cholinergic neuron death, acetylcholine (ACh) deficiency, metal ion dynamic equilibrium disorder, and deposition of amyloid and tau. Increased evidence suggests neuroinflammation and oxidative stress may cause AD. However, none of these factors induces AD independently, but they are all associated with the formation of Aβ and tau proteins. Current clinical treatments based on ACh deficiency can only temporarily relieve symptoms, accompanied with many side-effects...
November 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29091723/biomarker-profiling-in-reef-corals-of-tonga-s-ha-apai-and-vava-u-archipelagos
#10
Anderson B Mayfield, Chii-Shiarng Chen, Alexandra C Dempsey
Given the significant threats towards Earth's coral reefs, there is an urgent need to document the current physiological condition of the resident organisms, particularly the reef-building scleractinians themselves. Unfortunately, most of the planet's reefs are understudied, and some have yet to be seen. For instance, the Kingdom of Tonga possesses an extensive reef system, with thousands of hectares of unobserved reefs; little is known about their ecology, nor is there any information on the health of the resident corals...
2017: PloS One
https://www.readbyqxmd.com/read/29083098/click-chemistry-derived-pyridazines-electron-deficient-building-blocks-with-defined-conformation-and-packing-structure
#11
Irén Birkenfelder, Johannes Gurke, Lutz Grubert, Stefan Hecht, Bernd M Schmidt
A series of 3,6-bis(4-triazolyl)pyridazines equipped with terminal phenyl substituents with varying degree of fluorination were synthesized by the facile copper-catalyzed azide-alkyne cycloaddition and their structures were thoroughly investigated in the gas phase, in solution, and in the solid state by employing DFT calculations, NMR spectroscopy, and single-crystal X-ray diffraction, respectively. On the molecular level, their structure is governed by the strong preference of the triazole-pyridazine linkages for the anti-conformation...
October 30, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29073182/blood-parameters-as-biomarkers-in-a-salmonella-spp-disease-model-of-weaning-piglets
#12
Emili Barba-Vidal, Victor Fernando Buttow Roll, Edgar Garcia Manzanilla, Carlos Torrente, José Antonio Moreno Muñoz, José Francisco Pérez, Susana María Martín-Orúe
BACKGROUND: The weaning pig is used as an experimental model to assess the impact of diet on intestinal health. Blood parameters (BP) are considered a useful tool in humans, but there is very scarce information of such indicators in the weaning pig. The objective of the present study is to evaluate the use of different BP as indicators in an experimental model of salmonellosis. METHODOLOGY: Seventy-two 28-day-old piglets were divided into four groups in a 2x2 factorial arrangement, with animals receiving or not a probiotic combination based on B...
2017: PloS One
https://www.readbyqxmd.com/read/29070544/excess-iron-intake-as-a-factor-in-growth-infections-and-development-of-infants-and-young-children
#13
REVIEW
Bo Lönnerdal
The provision of iron via supplementation or the fortification of foods has been shown to be effective in preventing and treating iron deficiency and iron deficiency anemia in infants and young children. However, iron is a pro-oxidative element and can have negative effects on biological systems even at moderate amounts. An increasing number of studies have reported adverse effects of iron that was given to infants and young-children populations who initially were iron replete. These effects include decreased growth (both linear growth and weight), increased illness (usually diarrhea), interactions with other trace elements such as copper and zinc, altered gut microbiota to more pathogenic bacteria, increased inflammatory markers, and impaired cognitive and motor development...
October 25, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29057438/selected-trace-elements-concentrations-in-pregnancy-and-their-possible-role-literature-review
#14
Iwona Lewicka, Rafał Kocyłowski, Mariusz Grzesiak, Zuzanna Gaj, Przemysław Oszukowski, Joanna Suliburska
The aim of this study was to review the role of selected trace elements in pregnancy and fetal development. Citations related to the role of iron (Fe), zinc (Zn), manganese (Mn), copper (Cu) and selenium (Se) during pregnancy were searched in PubMed, Medline, Web of Science, using keywords and MeSH terms. Inadequate supply of trace elements can cause abnormalities of fetal development and predispose a child to disorders later on in life. Trace elements are the key elements of complex enzymes responsible for the modulation of the antioxidant defense system of the organism...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29046759/copper-deficiency-a-new-triad-anemia-leucopenia-and-myeloneuropathy
#15
Shoaib M Wazir, Ibrahim Ghobrial
Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate referral for bone marrow transplantation. Other conditions with similar presentations include infections, drug toxicity, autoimmunity, B12 deficiency, folate deficiency, myelodysplastic syndrome, aplastic anemia, and lymphoma with bone marrow involvement...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29043332/enhanced-thermoelectric-performance-in-ternary-spinel-cu4mn2te4via-the-synergistic-effect-of-tellurium-deficiency-and-chlorine-doping
#16
Hong Chen, Hua Lin, Yi Liu, Xin-Tao Wu, Li-Ming Wu
The chemistry of copper-based chalcogenides has received considerable attention due to their diverse structures and potential applications in the area of thermoelectric (TE) materials. In this communication, a series of spinel-type Cu4Mn2Te4-based samples have been successfully prepared and their high TE performances are attributed to the enhanced power factor and low thermal conductivity via the synergistic effect of Te deficiency and Cl doping. Consequently, a maximum TE figure of merit (ZT) of ∼0.4 was achieved for the Cu4Mn2Te3...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29034989/neurological-presentations-revealing-acquired-copper-deficiency-diagnosis-features-etiologies-and-evolution-in-seven-patients
#17
Aurélia Poujois, Nouzha Djebrani-Oussedik, Fabienne Ory-Magne, France Woimant
BACKGROUND: acquired copper deficiency (ACD) is a rare condition usually diagnosed from haematological changes. AIMS: characterize the diagnosis features and the evolution of patients with ACD revealed by neurological symptoms. METHODS: clinical, biological and MRI data were prospectively analysed at diagnosis and during follow-up under copper supplementation. RESULTS: seven patients were studied over a 5-year period...
October 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28977770/corynebacterium-pseudotuberculosis-and-copper-deficiency-in-a-male-rocky-mountain-bighorn-sheep-ovis-canadensis-canadensis-in-utah-usa
#18
E Jane Kelly, Annette Roug, Covy Jones, Josee Seamons, Jeffery O Hall
In 2015, an emaciated Rocky Mountain bighorn (Ovis canadensis) ram was submitted to the Utah Veterinary Diagnostic Laboratory for necropsy. There were numerous thick-walled abscesses subcutaneously and internally, and Corynebacterium pseudotuberculosis was isolated in pure culture. In addition, the ram was severely copper deficient, with a liver copper concentration of 1.6 mg/kg.
October 4, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28973536/the-mitochondrial-metallochaperone-sco1-maintains-ctr1-at-the-plasma-membrane-to-preserve-copper-homeostasis-in-the-murine-heart
#19
Zakery N Baker, Kimberly Jett, Aren Boulet, Amzad Hossain, Paul A Cobine, Byung-Eun Kim, Amr M El Zawily, Ling Lee, Glen F Tibbits, Michael J Petris, Scot C Leary
SCO1 is a ubiquitously expressed, mitochondrial protein with essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper homeostasis. SCO1 patients present with severe forms of early onset disease, and ultimately succumb from liver, heart or brain failure. However, the inherent susceptibility of these tissues to SCO1 mutations and the clinical heterogeneity observed across SCO1 pedigrees remain poorly understood phenomena. To further address this issue, we generated Sco1hrt/hrt and Sco1stm/stm mice in which Sco1 was specifically deleted in heart and striated muscle, respectively...
September 4, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28966241/effect-of-minerals-on-intestinal-iga-production-using-deep-sea-water-drinks
#20
Hisashi Shiraishi, Maho Fujino, Naoki Shirakawa, Nanao Ishida, Hiroki Funato, Ayumu Hirata, Noriaki Abe, Michiro Iizuka, Kohei Jobu, Junko Yokota, Mitsuhiko Miyamura
Minerals are essential for life, as they are a vital part of protein constituents, enzyme cofactors, and other components in living organisms. Deep sea water is characterized by its cleanliness and stable low temperature, and its possible health- and medical benefits are being studied. However, no study has yet evaluated the physical properties of the numerous commercially available deep sea water products, which have varying water sources and production methods. We analyzed these products' mineral content and investigated their effect on living organism, focusing on immune functions, and investigated the relation between physiological immunoactivities and mineral intake...
2017: Biological & Pharmaceutical Bulletin
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