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https://www.readbyqxmd.com/read/29458150/pink1-protects-auditory-hair-cells-and-spiral-ganglion-neurons-from-cisplatin-induced-ototoxicity-via-inducing-autophagy-and-inhibiting-jnk-signaling-pathway
#1
Qianqian Yang, Gaoying Sun, Haiyan Yin, Hongrui Li, Zhixin Cao, Jinghan Wang, Meijuan Zhou, Haibo Wang, Jianfeng Li
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1) gene encodes a serine/threonine kinase, which acts as a molecular sensor of mitochondrial health necessary for mitochondrial quality control. The present study was designed to examine whether PINK1 expressed in C57BL/6 murine cochlea and HEI-OC1 cells and, if so, to investigate the possible mechanisms underlying the action of PINK1 in cisplatin-induced death of sensory hair cells (HCs) and spiral ganglion neurons (SGNs) in vitro. The expression pattern of PINK1, formation of parkin particles, and autophagy were determined by immunofluorescent staining...
February 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29457749/chemical-and-biological-studies-on-bridelia-ferruginea-grown-in-nigeria
#2
Michael Afolayan, Radhakrishnan Srivedavyasasri, Olayinka T Asekun, Oluwole B Familoni, Samir A Ross
Phytochemical investigation of the methanolic extract of dried leaves of Bridelia ferruginea led to the isolation and identification of fourteen compounds (1-14): compound 1 [mixture of palmitic, stearic and oleic acids], stearyl monoester of 2-O-β-ᴅ-glucosylglycerol (2), 6β-hydroxy-(20R)-24-ethylcholest-4-en-3-one (3a), 6β-hydroxy-(20R)-24-ethylcholest-4,22-dien-3-one (3b), lutein (4), vomifoliol (5), corilagin (6), kaempferide-3-O-β-ᴅ-glucoside (7), myricetin (8), isomericitrin (9), isoquercetin (10), myricitrin (11), quercitrin (12), rutin (13), and β-sitosterol glucoside (14)...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457287/zero-te-based-pseudo-ct-image-conversion-in-the-head-and-its-application-in-pet-mr-attenuation-correction-and-mr-guided-radiation-therapy-planning
#3
Florian Wiesinger, Mikael Bylund, Jaewon Yang, Sandeep Kaushik, Dattesh Shanbhag, Sangtae Ahn, Joakim H Jonsson, Josef A Lundman, Thomas Hope, Tufve Nyholm, Peder Larson, Cristina Cozzini
PURPOSE: To describe a method for converting Zero TE (ZTE) MR images into X-ray attenuation information in the form of pseudo-CT images and demonstrate its performance for (1) attenuation correction (AC) in PET/MR and (2) dose planning in MR-guided radiation therapy planning (RTP). METHODS: Proton density-weighted ZTE images were acquired as input for MR-based pseudo-CT conversion, providing (1) efficient capture of short-lived bone signals, (2) flat soft-tissue contrast, and (3) fast and robust 3D MR imaging...
February 18, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29456385/dna-damage-protecting-activity-and-antioxidant-potential-of-launaea-taraxacifolia-leaves-extract
#4
Michael Buenor Adinortey, Charles Ansah, Alexander Weremfo, Cynthia Ayefoumi Adinortey, Genevieve Etornam Adukpo, Elvis Ofori Ameyaw, Alexander Kwadwo Nyarko
Background: The leaf extract of Launaea taraxacifolia commonly known as African Lettuce is used locally to treat dyslipidemia and liver diseases, which are associated with oxidative stress. Methanol extract from L. taraxacifolia leaves was tested for its antioxidant activity and its ability to protect DNA from oxidative damage. Materials and Methods: In vitro antioxidant potential of the leaf extract was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), and hydroxyl (OH) radical scavenging assays...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456213/association-of-serum-fibroblast-growth-factor-23-with-doppler-pulse-wave-velocity-in-hemodialysis-patients
#5
Walaa H Ibrahim, Ahmad B Ahmad, Noha G Sayed
We aimed to study the association of fibroblast growth factor-23 (FGF-23) as a novel cardiovascular risk factor with Doppler pulse wave velocity (PWV) as an arterial stiffness measuring tool in hemodialysis (HD) patients. We conducted a cross-sectional study in which blood samples from 86 HD patients were obtained to estimate FGF 23 and other parameters. Flow waveforms were obtained at two locations within right common carotid artery, and right femoral artery by Doppler ultrasound with ECG recorded in addition...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29454953/non-active-site-mutation-q123a-in-new-delhi-metallo-%C3%AE-lactamase-ndm-1-enhanced-its-enzyme-activity
#6
Abid Ali, Mohd W Azam, Asad U Khan
New Delhi metallo β-lactamase-1 is one of the carbapenemases, causing hydrolysis of almost all β-lactamase antibiotics. Seventeen different NDM variants have been reported so far, they varied in their sequences either by single or multiple amino acid substitutions. Hence, it is important to understand its structural and functional relation. In the earlier studies role of active site residues has been studied but non-active site residues has not studied in detail. Therefore, we have initiated to further comprehend its structure and function relation by mutating some of its non-active site residues...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454809/the-hidden-lipoproteome-of-staphylococcus-aureus
#7
Anica Graf, Richard J Lewis, Stephan Fuchs, Martin Pagels, Susanne Engelmann, Katharina Riedel, Jan Pané-Farré
Lipoproteins are attached to the outer leaflet of the membrane by a di- or tri-acylglyceryl moiety and are thus positioned in the membrane-cell wall interface. Consequently, lipoproteins are involved in many surface associated functions, including cell wall synthesis, electron transport, uptake of nutrients, surface stress response, signal transduction, and they represent a reservoir of bacterial virulence factors. Inspection of 123 annotated Staphylococcus aureus genome sequences in the public domain revealed that this organism devotes about 2-3% of its coding capacity to lipoproteins, corresponding to about 70 lipoproteins per genome...
February 1, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29454569/risk-of-recurrence-following-mesh-associated-incisional-hernia-repair-using-the-retromuscular-technique-in-patients-with-relevant-medical-conditions
#8
Maciej Stodolski, Marios Papadakis, Hubert Zirngibl, Peter C Ambe
BACKGROUND: Incisional hernia is a common problem following open abdominal surgery. Hernia repair in patients with relevant medical conditions is a topic of controversy due to the high risk of morbidity and recurrence. We investigated the risk of recurrence in patients with relevant medical conditions managed with a prosthesis in the retromuscular position. METHODS: A retrospective review of the data of patients undergoing midline incisional hernia repair was performed...
February 14, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29454330/comparison-of-visceral-body-fat-indices-and-anthropometric-measures-in-relation-to-chronic-kidney-disease-among-chinese-adults-from-a-large-scale-cross-sectional-study
#9
Ying Dong, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Jingyu Nie, Congyi Zheng, Jiali Wang, Lan Shao, Ye Tian, Runlin Gao
BACKGROUND: The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR). METHODS: A total of 29,516 participants aged 35 years or above were selected using a stratified multistage random sampling method across China during 2012-2015...
February 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29454319/treatment-of-upper-tract-urothelial-carcinoma-with-ureteroscopy-and-thulium-laser-a-retrospective-single-center-study
#10
Jin Wen, Zhi G Ji, Han Z Li
BACKGROUND: Treatment with the combination of ureteroscopy and thulium laser ablation may provide an alternative to radical nephroureterectomy (RNU) for patients with upper tract urothelial carcinoma (UTUC). The purpose of this study was to investigate the efficacy and safety of this technique. METHODS: We performed a retrospective review of the data for patients who were treated surgically for upper tract urothelial carcinoma in a single center. It included 32 patients treated by endoscopic thulium laser resection and 107 patients treated by radical nephroureterectomy (RNU)...
February 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29454103/corrigendum-to-sparse-asynchronous-cortical-generators-can-produce-measurable-scalp-eeg-signals-neuroimage-138-2016-123-133
#11
Nicolás von Ellenrieder, Jonathan Dan, Birgit Frauscher, Jean Gotman
No abstract text is available yet for this article.
February 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29453963/significance-of-spread-through-air-spaces-in-resected-pathological-stage-i-lung-adenocarcinoma
#12
Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: Spread through air spaces (STAS) is a recently described invasive pattern of lung cancer, which spreads within air spaces beyond the edge of the main tumor. In the current study, we investigated the significance of STAS in patients with pathological stage I adenocarcinoma. METHODS: STAS was assessed in a total of 276 patients with resected pathological stage I adenocarcinoma. STAS was classified as either no STAS, low STAS (1-4 single cells or clusters of STAS), or high STAS (≥5 single cells or clusters of STAS) using a 20x objective and a 10x ocular lens...
February 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29453609/leptin-receptor-gene-a-g-polymorphism-rs1137101-and-renal-cell-carcinoma
#13
Azza M Abdu Allah, Sally M El-Hefnway, Alshimaa M Alhanafy, Ahmed M Zahran, Heba E Kasem
Leptin plays an important role in carcinogenesis as leptin/leptin receptor signaling promotes the angiogenesis, proliferation, and inhibits epithelial cell apoptosis. Variants in the leptin receptor gene have potential associations with renal cell carcinoma (RCC). We aimed to investigate association of rs1137101 (A/G) polymorphism at LEPR gene with risk of RCC and patients survival. 123 individuals were classified into group I: 73 RCC patients and group II: 50 healthy controls. Genotyping of the Gln223Arg (A/G) polymorphism rs1137101 at LEPR gene was analyzed using allelic discrimination assay by Real-Time PCR technique...
February 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29453302/characteristics-and-publication-fate-of-unregistered-and-retrospectively-registered-clinical-trials-submitted-to-the-bmj-over-4-years
#14
Elizabeth Loder, Stephen Loder, Sophie Cook
OBJECTIVES: We sought to evaluate the characteristics and publication fate of improperly registered clinical trials submitted to a medical journal ( The BMJ ) over a 4-year period to identify common types of registration issues and their relation to publication outcomes. DESIGN: Research articles submitted to The BMJ and identified as unregistered or retrospectively registered by editors were included if they reported outcomes of a clinical trial. Relevant data regarding the trials were then extracted from each paper...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29452812/randomised-trial-comparing-forced-air-warming-to-the-upper-or-lower-body-to-prevent-hypothermia-during-thoracoscopic-surgery-in-the-lateral-decubitus-position
#15
S-H Min, S Yoon, S-H Yoon, J-H Bahk, J-H Seo
BACKGROUND: In the supine position, forced-air warming is more effective on the lower body than on the upper body to prevent intraoperative hypothermia. However, it is unknown in the lateral decubitus position. We thus compared forced-air warming on the upper and lower bodies in the lateral position. METHODS: Patients (n=123) were randomised to receive forced-air warming on the upper body or lower body during thoracoscopic surgery in the lateral position. We measured the nasopharyngeal temperature at 0, 30, 60, 90, and 120 min after lateral positioning during surgery and the infrared tympanic membrane temperature at 0, 30, 60, 90, and 120 min after surgery...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452713/physiochemical-characteristics-of-aerosol-particles-collected-from-the-jokhang-temple-indoors-and-the-implication-to-human-exposure
#16
Lulu Cui, Bu Duo, Fei Zhang, Chunlin Li, Hongbo Fu, Jianmin Chen
This paper presents a detailed study on the indoor air pollution in the Jokahng Temple at Tibet Plateau, and its implication to human health. The mean concentrations of PM 1.0 and PM 2.5 were 435.0 ± 309.5 and 483.0 ± 284.9 μg/m 3 , respectively. The PM 2.5 concentration exceeded the National Ambient Air Quality Standard (75 μg/m 3 ) by 6.4 times. The size-segregated aerosols displayed a bimodal distribution. One peak was observed in the fine mode (0.4-2.1 μm) and the other peak appeared in the coarse mode (2...
February 13, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29452567/a-critical-role-for-both-cd40-and-vla5-in-angiotensin-ii-mediated-thrombosis-and-inflammation
#17
Elena Y Senchenkova, Janice Russell, Shantel A Vital, Alper Yildirim, A Wayne Orr, D Neil Granger, Felicity N E Gavins
Angiotensin II (Ang-II)-induced hypertension is associated with accelerated thrombus formation in arterioles and leukocyte recruitment in venules. The mechanisms that underlie the prothrombotic and proinflammatory responses to chronic Ang-II administration remain poorly understood. We evaluated the role of CD40/CD40 ligand (CD40L) signaling in Ang-II-mediated microvascular responses and assessed whether and how soluble CD40L (sCD40L) contributes to this response. Intravital video microscopy was performed to analyze leukocyte recruitment and dihydrorhodamine-123 oxidation in postcapillary venules...
February 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29452283/posterolateral-fusion-plf-vs-transforaminal-lumbar-interbody-fusion-tlif-for-spondylolisthesis-a-systematic-review-and-meta-analysis
#18
REVIEW
Jay M Levin, Joseph E Tanenbaum, Michael P Steinmetz, Thomas E Mroz, Samuel C Overley
BACKGROUND CONTEXT: Lumbar fusion is an effective and durable treatment for symptomatic lumbar spondylolisthesis, however the current literature provides insufficient evidence to recommend an optimal surgical fusion strategy. PURPOSE: To compare the clinical outcomes, fusion rates, blood loss, and operative times between open posterolateral lumbar fusion (PLF) alone and open transforaminal lumbar interbody fusion + posterolateral fusion (TLIF) for spondylolisthesis...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29452221/a-scoping-review-and-survey-provides-the-rationale-perceptions-and-preferences-for-the-integration-of-randomized-and-non-randomized-studies-in-evidence-syntheses-and-grade-assessments
#19
Carlos A Cuello, Rebecca L Morgan, Jan Brozek, Nancy Santesso, Jos Verbeek, Kris Thayer, Gordon Guyatt, Holger J Schünemann
OBJECTIVES: To review the literature and obtain preferences and perceptions from experts regarding the role of randomized studies (RS) and non-randomized studies (NRS) in systematic reviews of intervention effects. STUDY DESIGN AND SETTING: Scoping review and survey of experts. Using levels of certainty developed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group, experts expressed their preferences about the use of RS and NRS in health syntheses...
February 13, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29451055/early-discontinuation-of-empirical-antibacterial-therapy-in-febrile-neutropenia-the-antibiostop-study
#20
Lenaïg Le Clech, Jean-Philippe Talarmin, Marie-Anne Couturier, Jean-Christophe Ianotto, Christophe Nicol, Ronan Le Calloch, Stéphanie Dos Santos, Pascal Hutin, Didier Tandé, Virginie Cogulet, Christian Berthou, Gaëlle Guillerm
INTRODUCTION: Immediate empirical antibiotic therapy is mandatory in febrile chemotherapy-induced neutropenia, but its optimal duration is unclear, especially in patients with fever of unknown origin (FUO). OBJECTIVES: The primary objective of this 20-month prospective observational study was to evaluate the feasibility and safety of short-term antibiotic treatment in afebrile or febrile patients exhibiting FUO, irrespective of their neutrophil count. The secondary objective was to describe the epidemiology of all episodes of febrile neutropenia...
February 16, 2018: Infectious Diseases
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