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https://www.readbyqxmd.com/read/29028965/tuberculin-skin-test-conversions-and-occupational-exposure-risk-in-us-healthcare-workers
#1
Claudia C Dobler, Wigdan H Farah, Mouaz Alsawas, Khaled Mohammed, Laura E Breeher, M Hassan Murad, Robin G Molella
Background: Health care workers (HCWs) undergo occupational tuberculosis (TB) screening at regular intervals. However, the risk of contracting TB at the workplace in a setting with a low background TB incidence is unclear. We aimed to evaluate the risk of tuberculin skin test (TST) conversion and the risk of occupational TB infection among HCWs in such a setting. Methods: We conducted a retrospective cohort study of employees of a large tertiary medical center in the US Midwest who had undergone TST screening during the study period January 1, 1998 to May 31, 2014...
October 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028888/rrdb-a-comprehensive-and-nonredundant-benchmark-for-rna-rna-docking-and-scoring
#2
Yumeng Yan, Sheng-You Huang
Motivation: With the discovery of more and more noncoding RNAs and their versatile functions, RNA-RNA interactions have received increased attention. Therefore, determination of their complex structures is valuable to understand the molecular mechanism of the interactions. Given the high cost of experimental methods, computational approaches like molecular docking have played an important role in the determination of complex structures, in which a benchmark is critical for the development of docking algorithms...
September 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028851/peri-implant-crestal-bone-changes-around-zirconia-implants-in-periodontally-healthy-and-compromised-patients
#3
Kristian Kniha, Stefan Milz, Heinz Kniha, Ayoub Nassim, Frank Hölzle, Ali Modabber
PURPOSE: No consensus regarding the efficacy of zirconia implants in maintaining peri-implant hard and soft tissue health has yet been obtained. The aim of this retrospective follow-up study was to gain knowledge about peri-implant bone behavior and about implant survival and success after treatment with zirconia dental implants in patients with normal and compromised soft and hard tissue conditions. MATERIALS AND METHODS: This follow-up study involved 86 patients with 123 zirconia implants (Straumann PURE Ceramic Implant) that were radiographically investigated directly after implant placement (day 0), 3 months after placement, and 1 year after the definitive implant crown placement...
October 13, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29028281/usefulness-of-the-index-of-nash-ion-for-the-diagnosis-of-steatohepatitis-in-patients-with-non-alcoholic-fatty-liver-an-external-validation-study
#4
Ramy Younes, Chiara Rosso, Salvatore Petta, Monica Cucco, Milena Marietti, Gian Paolo Caviglia, Alessia Ciancio, Maria Lorena Abate, Carlo Cammà, Antonina Smedile, Antonio Craxì, Giorgio Maria Saracco, Elisabetta Bugianesi
BACKGROUND & AIMS: The non-invasive identification of steatohepatitis (NASH) in patients with Non-Alcoholic Fatty Liver Disease is an unmet need in clinical practice. Index of NASH (ION) is a new tool for the prediction of NASH. We aimed to externally validate ION and to compare it with CK-18. Since necroinflammation precedes fibrosis, we also tested ION in combination with non-invasive tools for fibrosis. METHODS: We analyzed data from 292 Italian patients (169 Southern cohort, and 123 Northern cohort) with an histological diagnosis of NAFLD...
October 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29027535/transplant-glomerulopathy
#5
REVIEW
Edward J Filippone, Peter A McCue, John L Farber
In the renal allograft, transplant glomerulopathy represents a morphologic lesion and not a specific diagnosis. The hallmark pathologic feature is glomerular basement membrane reduplication by light microscopy or electron microscopy in the absence of immune complex deposits. Transplant glomerulopathy results from chronic, recurring endothelial cell injury that can be mediated by HLA alloantibodies (donor-specific antibodies), various autoantibodies, cell-mediated immune injury, thrombotic microangiopathy, or chronic hepatitis C...
October 13, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29027395/prognostic-value-of-programmed-death-ligand-1-pd-l1-expression-in-ovarian-clear-cell-carcinoma
#6
Jun Zhu, Hao Wen, Rui Bi, Yong Wu, Xiaohua Wu
OBJECTIVE: Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the expression of PD-L1 and its correlation with clinicopathologic features and clinical outcomes in ovarian clear cell carcinoma (OCCC). METHODS: The PD-L1 expression was measured by tissue-microarray-based immunohistochemistry from 122 eligible patients diagnosed with OCCC...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027384/survey-for-correlation-between-biofilm-formation-and-virulence-determinants-in-a-collection-of-pathogenic-and-fecal-enterococcus-faecalis-isolates
#7
Fereshteh Saffari, Mohammad Sadegh Dalfardi, Shahla Mansouri, Roya Ahmadrajabi
BACKGROUND: Enterococcus faecalis is an opportunistic pathogen that causes most of the enterococcal infections. Among the different factors implicated in the pathogenesis of these organisms, biofilm formation and antibiotic resistance are the most important. The ability for biofilm formation has been attributed to the presence of some virulence genes. However, no definite correlation has been found. This study aimed to detect biofilm formation and antibiotic resistance patterns in E. faecalis isolates collected from clinical and fecal samples, and to investigate possible correlation between some virulence genes (esp, cyl, gelE) and biofilm formation...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29026580/-123-i-bmipp-single-photon-emission-computed-tomography-for-diagnosing-chest-pain-in-patients-with-nonobstructive-coronary-angiograms-takotsubo-or-vasospasm
#8
Yuta Seko, Kenichi Sasaki, Takao Kato, Moriaki Inoko
The decreased 123I-BMIPP uptake, while having normal perfusion, in the correspondent coronary artery territory is caused by a delayed metabolic recovery after the recovery of perfusion. This phenomenon termed ischemic memory can clearly differentiate vasospastic angina from other chest pain syndromes.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29025276/once-daily-versus-twice-daily-enoxaparin-for-the-treatment-of-acute-venous-thromboembolism-in-cancer-patients
#9
Katherine Fuller, Stephanie Malecki, Lisa Anselmo, Matthew E Borrego, Bernadette Jakeman, Allison Burnett
BACKGROUND: No randomized controlled trials have investigated enoxaparin once versus twice daily for venous thromboembolism (VTE) treatment in cancer patients. OBJECTIVE: To compare the safety and efficacy of enoxaparin 1 mg/kg twice daily versus enoxaparin 1.5 mg/kg/day for the treatment of acute VTE in cancer patients. METHODS: This was a single-center, retrospective, observational cohort study. Adults with active cancer and an acute VTE were included...
October 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29025045/clinical-features-and-outcomes-in-secondary-adult-hemophagocytic-lymphohistiocytosis
#10
Meng Zhou, Li Li, Qiaolei Zhang, Shanshan Ma, Jianai Sun, Lixia Zhu, Danlei Lu, Jingjing Zhu, De Zhou, Yanlong Zheng, Xiudi Yang, Mixue Xie, Mingyu Zhu, Xiujin Ye, Wanzhuo Xie
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by an infrequent but immune-mediated life-threatening disease, with confusing clinical manifestations, rapidly deteriorating health, high morbidity and mortality and challenging diagnosis. METHODS: To improve the recognition and understanding of this disease, we analyzed clinical and laboratory findings and prognostic factors from 205 adult patients diagnosed with HLH in a large cohort managed at a single medical center from January 2011 to December 2015...
September 15, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29024738/new-hybrid-mini-laparoendoscopic-single-site-mi-less-partial-nephrectomy-with-early-unclamped-technique-for-renal-tumors-with-intermediate-padua-score-ideal-phase-2a
#11
Christopher Springer, Felix Kawan, Roberto La Rocca, Nasreldin Mohammed, Paolo Fornara, Vincenzo Mirone, Francesco Greco
OBJECTIVE: To evaluate a new hybrid technique which we defined mini-laparoendoscopic single-site partial nephrectomy (MILESS-PN) for renal masses presenting an intermediate PADUA score. MATERIAL AND METHODS: Forty consecutive cases of MILESS-PN performed between April 2013 and November 2015 were included in this study. MILESS consisted in the simultaneous use of two 3 mm pararectal trocars and an umbilical SILS trocar; the sequence of steps of MILESS-PN was comparable to standard laparoscopic partial nephrectomy...
October 9, 2017: Urology
https://www.readbyqxmd.com/read/29024074/comparison-of-subjective-wellbeing-in-substance-users-and-the-parents-or-partners-of-substance-users
#12
Robert J Tait
INTRODUCTION AND AIMS: There is growing interest in the impact of substance use on both the individual consumer's subjective wellbeing (SWB) and the reduced SWB of those closely connected to him or her. The study aimed to compare SWB among substance users ('consumers') and the parents or partners affected by another's substance use, and to evaluate the effect of counselling on changed SWB to 6 months. DESIGN AND METHODS: The study used longitudinal data from a not-for-profit treatment service based in Perth, Australia...
October 12, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29024003/molecular-characterization-of-the-llama-fgf5-gene-and-identification-of-putative-loss-of-function-mutations
#13
M S Daverio, L Vidal-Rioja, E N Frank, F Di Rocco
Llama, the most numerous domestic camelid in Argentina, has good fiber-production ability. Although a few genes related to other productive traits have been characterized, the molecular genetic basis of fiber growth control in camelids is still poorly understood. Fibroblast growth factor 5 (FGF5) is a secreted signaling protein that controls hair growth in humans and other mammals. Mutations in the FGF5 gene have been associated with long-hair phenotypes in several species. Here, we sequenced the llama FGF5 gene, which consists of three exons encoding 813 bp...
October 11, 2017: Animal Genetics
https://www.readbyqxmd.com/read/29023524/polymorphism-il-1rn-rs419598-reduces-the-susceptibility-to-generalized-periodontitis-in-a-population-of-european-descent
#14
Francisco Mesa, Esperanza Lanza, Llenalia García, Rafael Marfil-Alvarez, Antonio Magan-Fernandez
Interleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and β and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the load of five periodontopathogenic bacteria and periodontal clinical variables. A cross-sectional analytic study was conducted in 123 patients with GCP, 60 patients with GAgP, and 20 controls...
2017: PloS One
https://www.readbyqxmd.com/read/29023064/impact-of-zeatin-and-thidiazuron-on-phenols-and-flavonoids-accumulation-in-callus-cultures-of-gardenia-gardenia-jasminoides
#15
Ahmed Mohamed Magdy Gabr, Nermeen Mohamed Arafa, Amal Abd El-Latif El-Ashry, Mohamed Kamal El-Bahr
BACKGROUND AND OBJECTIVE: Gardenia (Gardenia jasminoides) has many pharmacological actions such as anti-inflammatory, antioxidant and fibrolytic activities and cytotoxic effects, etc. This study was conducted to recognize the effect of zeatin and thidiazuron (TDZ) on callus proliferation, total phenolic content, total flavonoids and DPPH scavenging activity of gardenia callus cultures. MATERIALS AND METHODS: Calli were cultured on Murashige and Skoog (MS) medium supplement with different concentrations (2, 4 or 6 mg L-1) of zeatin or TDZ individually as well as combination of 2 mg L-1 zeatin+4 mg L-1 TDZ...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29021897/patient-outcome-of-emergency-laparotomy-improved-with-increasing-number-of-surgeons-on-call-in-a-university-hospital-audit-loop
#16
Anwar Hussain, Fahad Mahmood, Chui Teng, Sadaf Jafferbhoy, David Luke, Achilleas Tsiamis
AIM: Emergency laparotomy is a commonly performed high-mortality surgical procedure. The National Emergency Laparotomy Network (NELA) published an average mortality rate of 11.1% and a median length of stay equivalent to 16.3 days in patients undergoing emergency laparotomy. This study presents a completed audit loop after implementing the change of increasing the number of on-call surgeons in the general surgery rota of a university hospital. The aim of this study was to evaluate the outcomes of emergency laparotomy in a single UK tertiary centre after addition of one more consultant in the daily on-call rota...
November 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29021757/cerebral-small-vessel-disease-burden-is-associated-with-motor-performance-of-lower-and-upper-extremities-in-community-dwelling-populations
#17
Ning Su, Fei-Fei Zhai, Li-Xin Zhou, Jun Ni, Ming Yao, Ming-Li Li, Zheng-Yu Jin, Gao-Lang Gong, Shu-Yang Zhang, Li-Ying Cui, Feng Tian, Yi-Cheng Zhu
Objective: To investigate the correlation between cerebral small vessel disease (CSVD) burden and motor performance of lower and upper extremities in community-dwelling populations. Methods: We performed a cross-sectional analysis on 770 participants enrolled in the Shunyi study, which is a population-based cohort study. CSVD burden, including white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMBs), perivascular spaces (PVS), and brain atrophy were measured using 3T magnetic resonance imaging...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29020647/body-image-and-paranoia
#18
Felicity Waite, Daniel Freeman
Paranoia builds upon feelings of vulnerability. Our clinical experience indicates that negative body image, including concerns regarding weight, may be one source of feeling vulnerable and hence raise the risk of paranoia. There has been no empirical test of an association between body image and paranoia. Our aim was to provide the first test of this issue by examining in epidemiologically representative cohorts the cross-sectional associations between paranoia and a proxy measure of body image. This was an initial exploration of a potentially important but overlooked issue...
October 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29020373/artemether-lumefantrine-versus-chloroquine-for-the-treatment-of-uncomplicated-plasmodium-knowlesi-malaria-can-know-an-open-label-randomized-controlled-trial
#19
Matthew J Grigg, Timothy William, Bridget E Barber, Giri S Rajahram, Jayaram Menon, Emma Schimann, Christopher S Wilkes, Kaajal Patel, Arjun Chandna, Ric N Price, Tsin W Yeo, Nicholas M Anstey
Background: Plasmodium knowlesi is reported increasingly across Southeast Asia, and is the commonest cause of malaria in Malaysia. No randomized trials have assessed comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria. Methods: A randomized-controlled trial was conducted in 3 district hospitals in Sabah, Malaysia to compare the efficacy of AL against chloroquine (CQ) for uncomplicated knowlesi malaria. Participants were included if >10kg, parasitemia <20,000/μL, and had a negative Pf-HRP2 rapid-diagnostic-test...
September 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020353/differential-effects-of-pcsk9-variants-on-risk-of-coronary-disease-and-ischaemic-stroke
#20
Jemma C Hopewell, Rainer Malik, Elsa Valdés-Márquez, Bradford B Worrall, Rory Collins
Aims: PCSK9 genetic variants that have large effects on low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Methods and results: Associations of the loss-of-function PCSK9 genetic variant (rs11591147; R46L), and five additional PCSK9 variants, with IS and IS subtypes (cardioembolic, large vessel, and small vessel) were estimated in a meta-analysis involving 10 307 IS cases and 19 326 controls of European ancestry...
July 17, 2017: European Heart Journal
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