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Yuko M Komesu, Holly E Richter, Benjamin Carper, Darrell L Dinwiddie, Emily S Lukacz, Nazema Y Siddiqui, Vivian W Sung, Halina M Zyczynski, Beri Ridgeway, Rebecca G Rogers, Lily A Arya, Donna Mazloomdoost, Marie G Gantz
INTRODUCTION & HYPOTHESIS: Previous studies have suggested that women with urinary incontinence have an altered urinary microbiome. We hypothesized that the microbiome in women with mixed urinary incontinence (MUI) differed from controls and tested this hypothesis using bacterial gene sequencing techniques. METHODS: This multicenter study compared the urinary microbiome in women with MUI and similarly aged controls. Catheterized urine samples were obtained; v4-6 regions of the 16S rRNA gene were sequenced to identify bacteria...
June 16, 2018: International Urogynecology Journal
Akira Toriihara, Hiromitsu Daisaki, Akihiro Yamaguchi, Makoto Kobayashi, Shogo Furukawa, Katsuya Yoshida, Jun Isogai, Ukihide Tateishi
PURPOSE: To evaluate potential of a semiquantitative method using standardized uptake value (SUV) in 123 I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123 I-FP-CIT) single photon emission computed tomography/computed tomography (SPECT/CT) compared with specific binding ratio (SBR). MATERIALS AND METHODS: First, we performed a phantom study to validate the accuracy of measuring SUV. 52 patients (25 male, 27 female; mean age of 75.1-year-old; 40 and 12 patients with neurodegenerative diseases with or without presynaptic dopaminergic deficits, respectively) were enrolled in a retrospective study...
June 14, 2018: Clinical Imaging
T S Moores, S A Khan, B D Chatterton, G Harvey, S C Lewthwaite
BACKGROUND: Infection occurs in 2-4% of arthroplasty cases, identifying potential sources of infection can help to reduce infection rates. The aim of this study was to identify the impact and potential for contamination of our hands and gowns whilst scrubbing using sterile surgical helmet systems (SSHS). METHOD: A colony-forming unit (CFU) is a pathogenic particle of 0.5 to 5 micrometres. A standard arthroplasty hood and a SSHS with and without the fan on for a 3-minute exposure to represent scrubbing time, were tested on 3 subjects and a mannequin with concurrent particle counts and culture plates...
June 13, 2018: Journal of Hospital Infection
Stephen Corson, Chris Robertson, Arlene Reynolds, Jim McMenamin
BACKGROUND: For the last 17 years, the UK has employed a routine influenza vaccination programme with the aim of reducing the spread of seasonal influenza. In mid-2000, the programme moved from a purely risk-based approach to a risk and age group targeted approach with all those aged 65+ years being included. To date, there has been no assessment of the population effectiveness of this age targeted policy in Scotland. OBJECTIVES: Statistical modelling techniques were used to determine what impact the routine vaccination of those aged 65+ years has had on influenza related morbidity and mortality in Scotland...
June 16, 2018: Influenza and Other Respiratory Viruses
Emily D Geyer, Candice Burrier, Dmitry Tumin, Don Hayes, Sylvester M Black, W Kenneth Washburn, Joseph D Tobias
INTRODUCTION: Domino liver transplantation (DLT) utilizes the explanted liver of one liver transplant recipient as a donor graft in another patient. While there may be unique risks associated with DLT, it is unclear if DLT has less favorable long term outcomes than deceased donor liver transplantation (DDLT). We used a propensity score matching approach to compare the outcomes of DLT recipients to DDLT recipients in a large national registry. METHODS: The United Network for Organ Sharing registry was queried for patients undergoing DLT or DDLT in 2002-2016...
June 15, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Cristina Tassorelli, Licia Grazzi, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Stefanie Dorlas, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti
OBJECTIVE: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled trial. METHODS: A total of 248 participants with episodic migraine with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants were to repeat treatment if pain had not improved in 15 minutes...
June 15, 2018: Neurology
Sven Kohler, Stefan Kaspers, Afshin Salsali, Cordula Zeller, Hans J Woerle
OBJECTIVE: To assess the effect of empagliflozin on bone fractures and bone mineral density in patients with type 2 diabetes in pooled placebo-controlled trial data and a head-to-head study versus glimepiride. RESEARCH DESIGN AND METHODS: Pooled data were analyzed from patients who were randomized 1:1:1 to empagliflozin 10 mg, empagliflozin 25 mg, or placebo in phase I-III clinical trials. Data were also analyzed from the EMPA-REG H2H-SU trial in which patients received empagliflozin 25 mg or glimepiride as an add-on to metformin for 104 weeks with a 104-week extension...
June 15, 2018: Diabetes Care
Manuela Matesan, Santhosh Gaddikeri, Katelan Longfellow, Robert Miyaoka, Saeed Elojeimy, Shana Elman, Shu-Ching Hu, Satoshi Minoshima, David Lewis
BACKGROUND AND PURPOSE: Computer-based analysis of Dopamine transporter imaging (DaTscan) can aid in image interpretation. In this study, we examined the distribution of putamen-to-caudate ratios (PCRs) obtained by using a clinically available semiquantification method. METHODS: Medical records of 32 patients (M:16) with a diagnosis of Parkinson's disease (PD) (n = 22) or Parkinson's plus syndromes (PPS) (n = 10) based on clinical follow-up, were retrospectively reviewed...
June 14, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Cristina E Tognon, Bo Rafn, Naniye Malli Cetinbas, Takumi Kamura, Genny Trigo, Barak Rotblat, Fumihiko Okumura, Masaki Matsumoto, Christine Chow, Monika Davare, Michael Pollak, Thibault Mayor, Poul H Sorensen
Many oncogenes, including chimeric oncoproteins, require insulin-like growth factor 1 receptor (IGF1R) for promoting cell transformation. The ETS variant 6 (ETV6)-neurotrophic receptor tyrosine kinase 3 (NTRK3) (EN) chimeric tyrosine kinase is expressed in mesenchymal, epithelial, and hematopoietic cancers and requires the IGF1R axis for transformation. However, current models of IGF1R-mediated EN activation are lacking mechanistic detail. We demonstrate here that IGF-mediated IGF1R stimulation enhances EN tyrosine phosphorylation and that blocking IGF1R activity or decreasing protein levels of the adaptor protein insulin receptor substrate 1/2 (IRS1/2) results in rapid EN degradation...
June 14, 2018: Journal of Biological Chemistry
Ummu K Jamaludin, Fatanah M Suhaimi, Normy Norfiza Abdul Razak, Azrina Md Ralib, Mohd Basri Mat Nor, Christopher G Pretty, Luqman Humaidi
BACKGROUND AND OBJECTIVE: Blood glucose variability is common in healthcare and it is not related or influenced by diabetes mellitus. To minimise the risk of high blood glucose in critically ill patients, Stochastic Targeted Blood Glucose Control Protocol is used in intensive care unit at hospitals worldwide. Thus, this study focuses on the performance of stochastic modelling protocol in comparison to the current blood glucose management protocols in the Malaysian intensive care unit...
August 2018: Computer Methods and Programs in Biomedicine
Eleni Papakrivou, Demosthenes Makris, Efstratios Manoulakas, Marios Karvouniaris, Epaminondas Zakynthinos
BACKGROUND: Ventilator-associated pneumonia (VAP) might be increased in cases with intra-abdominal hypertension (IAH). However, despite animal experimentation and physiological studies on humans in favor of this hypothesis, there is no definitive clinical data that IAH is associated with VAP. We therefore aimed to study whether IAH is a risk factor for increased incidence of VAP in critical care patients. This 1-center prospective observational cohort study was conducted in the intensive care unit of the University Hospital of Larissa, Greece, during 2013 to 2015...
January 1, 2018: Journal of Intensive Care Medicine
Antonio Méndez-Durán, Manuel Humberto Ignorosa-Luna, Gilberto Pérez-Aguilar, Francisco Jesús Rivera-Rodríguez, Luis Rafael López-Ocaña
Background: The Instituto Mexicano del Seguro Social (IMSS) is the institution with the greatest health coverage in Mexico. In adherence to existing and committed to provide specialized services to specific populations (vulnerable age groups, such as children and young people in primary, secondary and higher education, productive and without social security educational training), this gives the renal replacement therapy -peritoneal dialysis and hemodialysis- at no cost to students. Methods: Cross-sectional and retrospective study conducted from 1 to 30 September 2016; Census Patients with Chronical Renal Failure, sociodemographic and type of therapy are identified; direct costs are estimated...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
Cong-Cong Guo, Chun-Hong Jiao, Zhen-Mei Gao
OBJECTIVE: To explore the effects of long non-coding RNA (lncRNA) brain-derived neurotrophic factor anti-sense (BDNF-AS) on the Aβ25-35 -induced neurotoxicity in PC12 cells. METHODS: PC12 cells were induced by Aβ25-35 to construct cell injury models of Alzheimer's disease (AD), and then transfected with siRNA-BDNF-AS. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect the expressions of BDNF-AS and BDNF. Besides, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Hoechst33342 staining were utilized to analyze the cell viability and apoptosis, respectively, Western blotting to evaluate the protein expressions, immunofluorescence to assess the Cytochrome C (Cyt C) release, and Rhodamine 123 (Rh123) to measure the mitochondrial membrane potential (MMP)...
June 14, 2018: Neurological Research
Murat Bilgel, Yang An, Jessica Helphrey, Wendy Elkins, Gabriela Gomez, Dean F Wong, Christos Davatzikos, Luigi Ferrucci, Susan M Resnick
Understanding short-term cognitive decline in relation to Alzheimer's neuroimaging biomarkers in early stages of the development of neuropathology and neurodegeneration will inform participant recruitment and monitoring strategies in clinical trials aimed at prevention of cognitive impairment and dementia. We assessed associations among neuroimaging measures of cerebral amyloid pathology, a hallmark Alzheimer's neuropathology, hippocampal atrophy, and prospective cognition among 171 cognitively normal Baltimore Longitudinal Study of Aging participants (baseline age 56-95 years, 48% female, 562 cognitive assessments, 3...
June 12, 2018: Brain: a Journal of Neurology
Lishen Shan, Xinyuan Kang, Fen Liu, Xuxu Cai, Xiaohua Han, Yunxiao Shang
Vitamin D receptors (VDRs) are associated with the occurrence and development of asthma. The aim of the present study was to analyze the secondary structure and B‑cell and T‑cell epitopes of VDR using online prediction software and aid in the future development of a highly efficient epitope‑based vaccine against asthma. Blood samples were collected from peripheral blood of asthmatic children. Reverse transcription quantitative‑polymerase chain reaction (RT‑qPCR) was performed to detect the expression of VDR in the peripheral blood...
June 13, 2018: Molecular Medicine Reports
Leyla Bashirova, Evgenia Dorokhova, Vadim Sivkov, Ekaterina Novichkova
Data file presents information on the variation in sea surface temperatures (SST), as well as geochemical (e.g. stable isotope, calcium carbonate), micropaleontological and grain size data from the Gloria Drift (Northwest Atlantic). The data are obtained from the three marine sediment gravity core sections (AMK-4493, AI-3646 and AI-3415) which were formed during Quaternary period. Dataset contains SST values (winter and summer: 0-50 water layer) and ice-rafted debris (IRD) counts, each in 308 samples; stable isotope data (δ18 O and δ13 C) from 235 samples; calcium carbonate content from 351 samples; relative abundance of polar species of planktonic foraminifera Neogloboquadrina pachyderma (sinistral) (Ehrenberg) in 51 samples, data of grain size analysis in bulk sediments (123 samples) and carbonate-free sediments (664)...
August 2018: Data in Brief
Nisha Stephan, Anna Halama, Sweety Mathew, Shahina Hayat, Aditya Bhagwat, Lisa Sara Mathew, Ilham Diboun, Joel Malek, Karsten Suhre
This article provides detailed information on the phenotypes and the metabolic profiles of 196 date fruits from 123 unique date fruit varieties. These date fruits are extensively diverse in their country of origin, variety and post harvesting conditions. We used a non-targeted mass-spectrometry based metabolomics approach to metabolically characterize date fruits, and measured 427 metabolites from a wide range of metabolic pathways. The metabolomics data for all the date fruit samples are available at the NIH Common Fund's Data Repository and Coordinating Center (supported by NIH grant, U01-DK097430) website, http://www...
June 2018: Data in Brief
Sarat A Badmus, Ayotunde I Ajaiyeoba, Bernice O Adegbehingbe, Oluwatoyin H Onakpoya, Adenike O Adeoye, Sanyaolu A Ameye
PURPOSE: The study aimed at determining the relationship between refraction and anthropometric measurements and the relationship between the level of education and refractive status in a Nigerian young adult population. MATERIALS AND METHODS: Healthy volunteers from the students and staff of a teaching hospital in South-Western Nigeria were studied. Demographic profiles including participants' highest educational status, parental educational level, and the age at first formal school enrollment were documented...
January 2018: Middle East African Journal of Ophthalmology
H M M T B Herath, B S D P Keragala, W A E Udeshika, S S M Samarawickrama, S P Pahalagamage, Aruna Kulatunga, Chaturaka Rodrigo
OBJECTIVES: This study aimed to assess the knowledge, attitudes and skills of non-specialist doctors on timely referral of suspicious lesions for melanoma diagnosis. RESULTS: One hundred and twenty-three doctors (mean age; 30.4 years, SD ± 8.015) were enrolled. Very few (3.3%) correctly stated all four types of melanoma. Only 8.1% of the total sample had been trained to perform a total body examination for skin cancer detection and a majority (110/123) had never performed one...
June 14, 2018: BMC Research Notes
Søren Kristiansen, Lennart Friis-Hansen, Claus Antonio Juel Jensen, Steen Ingemann Hansen
We verified the lactate dehydrogenase (LDH) reference interval (RI) provided by the Nordic Reference Interval Project (NORIP). The serum LDH concentration was analysed on the Dimension Vista 1500 system with an IFCC method with a bias of +2.1 % and +2.7 % against NFKK Reference Serum X and ERM-AD453/IFCC, respectively, showing verification of transference of the NORIP RI. Selective data mining in clinical laboratory information systems for retrospective serum LDH test results was used to calculate an indirect RI...
June 13, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
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