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https://www.readbyqxmd.com/read/29457761/degradation-of-anti-inflammatory-drugs-in-municipal-wastewater-by-heterogeneous-photocatalysis-and-electro-fenton-process
#1
Minerva Villanueva-Rodríguez, Ricardo Bello-Mendoza, Aracely Hernández-Ramírez, Edgar J Ruiz-Ruiz
Non-steroidal anti-inflammatory drugs (NSAID) are compounds frequently found in municipal wastewater and their degradation by conventional wastewater treatment plants (WWTP) is generally incomplete. This study compared the efficiency of two advanced oxidation processes, namely heterogeneous photocatalysis (HP) and electro-Fenton (EF), in the degradation of a mixture of common NSAID (diclofenac, ibuprofen and naproxen) dissolved in either deionized water or effluent from a WWTP. Both processes were effective in degrading the NSAID mixture and the trend of degradation was as follows, diclofenac>naproxen>ibuprofen...
February 19, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29454273/mechanosensitive-adhesion-complexes-in-epithelial-architecture-and-cancer-onset
#2
REVIEW
Minerva Bosch-Fortea, Fernando Martín-Belmonte
Mechanical signals from the extracellular space are paramount to coordinate tissue morphogenesis and homeostasis. Although there is a wide variety of cellular mechanisms involved in transducing extracellular forces, recent literature emphasizes the central role of two main adhesion complexes in epithelial mechanosensitive processes: focal adhesions and adherens junctions. These biomechanical sensors can decode physical signals such as matrix stiffness or intercellular tension into a wide range of coordinated cellular responses, which can impact cell differentiation, migration, and proliferation...
February 14, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29439412/congenital-vomer-agenesis-a-rare-and-poorly-understood-condition-revealed-by-cone-beam-ct
#3
David Jun Yan, Vincent Lenoir, Sibylle Chatelain, Salvatore Stefanelli, Minerva Becker
Isolated congenital vomer agenesis is a very rare and poorly understood condition. In the context of dental work-up by cone-beam computed tomography (CBCT), the explored volume of the facial bones occasionally reveals incidental abnormalities. We report the case of a 13-year old Caucasian female who underwent CBCT for the pre-treatment evaluation of primary failure of tooth eruption affecting the permanent right upper and inferior molars. CBCT depicted a large defect of the postero-inferior part of the nasal septum without associated soft tissue abnormality and without cranio-facial malformation or cleft palate...
February 10, 2018: Diagnostics
https://www.readbyqxmd.com/read/29427212/recontacting-patients-with-updated-genetic-testing-recommendations-for-medullary-thyroid-carcinoma-and-pheochromocytoma-or-paraganglioma
#4
Minerva A Romero Arenas, Thereasa A Rich, Samuel M Hyde, Naifa L Busaidy, Gilbert J Cote, Mimi I Hu, Robert F Gagel, Paul W Gidley, Camilo Jimenez, Michael E Kupferman, Susan K Peterson, Steven I Sherman, Anita Ying, Roland L Bassett, Steven G Waguespack, Nancy D Perrier, Elizabeth G Grubbs
BACKGROUND: No guidelines exist regarding physicians' duty to inform former patients about novel genetic tests that may be medically beneficial. Research on the feasibility and efficacy of disseminating information and patient opinions on this topic is limited. METHODS: Adult patients treated at our institution from 1950 to 2010 for medullary thyroid cancer, pheochromocytoma, or paraganglioma were included if their history suggested being at-risk for a hereditary syndrome but genetic risk assessment would be incomplete by current standards...
February 9, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29426583/-use-of-new-technologies-by-adolescents-in-the-search-for-health-information
#5
Minerva Blázquez Barba, Dolores Gómez Romero, Isidora Frontaura Fernández, Abdón Camacho Ojeda, Francisco M Rodríguez Salas, Higinio Toriz Cano
OBJECTIVE: To describe Internet sources used by adolescents to consult health information and their sociodemographic characteristics, as well as to identify the variables that influence the choice of Internet site. DESIGN: Cross-sectional descriptive study. Survey adapted from the questionnaire validated by Rideout. PARTICIPANTS AND LOCATION: Adolescents aged 12-18 from 4schools in rural municipalities. RESULTS: The study included a total of 405 adolescents, of whom 51...
February 6, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29403285/progranulin-modulates-cholangiocarcinoma-cell-proliferation-apoptosis-and-motility-via-the-pi3k-pakt-pathway
#6
Minerva Daya, Watcharin Loilome, Anchalee Techasen, Malinee Thanee, Prakasit Sa-Ngiamwibool, Attapol Titapun, Puangrat Yongvanit, Nisana Namwat
Progranulin (PGRN) is a growth factor normally expressed in rapidly cycling epithelial cells for growth, differentiation, and motility. Several studies have shown the association of PGRN overexpression with the progression of numerous malignancies, including cholangiocarcinoma (CCA). However, the underlying mechanisms on how PGRN modulates CCA cell proliferation and motility is not clear. In this study, we investigated the prognostic significance of PGRN expression in human CCA tissue and the mechanisms of PGRN modulation of CCA cell proliferation and motility...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29387774/dermoscopy-of-eccrine-angiomatous-hamartoma-the-popcorn-pattern
#7
Sandra Cecilia García-García, Marcela Saeb-Lima, Alejandra Villarreal-Martínez, Osvaldo Tomás Vázquez-Martínez, Yuri Igor López-Carrera, Jorge Ocampo-Candiani, Minerva Gómez-Flores
No abstract text is available yet for this article.
March 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29382629/examining-influences-of-parenting-styles-and-practices-on-physical-activity-and-sedentary-behaviors-in-latino-children-in-the-united-states-integrative-review
#8
REVIEW
Ana Cristina Lindsay, Minerva Wasserman, Mario A Muñoz, Sherrie F Wallington, Mary L Greaney
BACKGROUND: Research indicates that parents influence their children's physical activity (PA) and sedentary behaviors (SB) through their parenting styles and practices. OBJECTIVE: The objectives of this paper were to evaluate existing research examining the associations between parenting styles, parenting practices, and PA and SB among Latino children aged between 2 and 12 years, highlight limitations of the existing research, and generate suggestions for future research...
January 30, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29371216/bmal1-in-perivascular-adipose-tissue-regulates-resting-phase-blood-pressure-through-transcriptional-regulation-of-angiotensinogen
#9
Lin Chang, Wenhao Xiong, Xiangjie Zhao, Yanbo Fan, Yanhong Guo, Minerva Garcia-Barrio, Jifeng Zhang, Zhisheng Jiang, Jiandie D Lin, Y Eugene Chen
Background -The perivascular adipose tissue (PVAT), surrounding vessels, constitutes a distinct functional integral layer of the vasculature required to preserve vascular tone under physiological conditions. However, there is little information regarding the relationship between PVAT and blood pressure regulation, including its potential contributions to circadian blood pressure variation. Methods -Using unique brown adipocyte-specific aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) and angiotensinogen (Agt) knock out mice we determined the vasoactivity of homogenized PVAT in aortic rings and how brown-adipocyte peripheral expression of Bmal1 and Agt in PVAT regulate the amplitude of diurnal change in blood pressure in mice...
January 25, 2018: Circulation
https://www.readbyqxmd.com/read/29369381/why-arguments-against-infanticide-remain-convincing-a-reply-to-r%C3%A3-s%C3%A3-nen
#10
Daniel Rodger, Bruce P Blackshaw, Clinton Wilcox
In 'Pro-life arguments against infanticide and why they are not convincing' Joona Räsänen argues that Christopher Kaczor's objections to Giubilini and Minerva's position on infanticide are not persuasive. We argue that Räsänen's criticism is largely misplaced, and that he has not engaged with Kaczor's strongest arguments against infanticide. We reply to each of Räsänen's criticisms, drawing on the full range of Kaczor's arguments, as well as adding some of our own.
January 25, 2018: Bioethics
https://www.readbyqxmd.com/read/29361501/synthetic-high-density-lipoprotein-mediated-targeted-delivery-of-liver-x-receptors-agonist-promotes-atherosclerosis-regression
#11
Yanhong Guo, Wenmin Yuan, Bilian Yu, Rui Kuai, Wenting Hu, Emily E Morin, Minerva T Garcia-Barrio, Jifeng Zhang, James J Moon, Anna Schwendeman, Y Eugene Chen
Targeting at enhancing reverse cholesterol transport (RCT) is apromising strategy for treating atherosclerosis via infusion of reconstitute high density lipoprotein (HDL) as cholesterol acceptors or increase of cholesterol efflux by activation of macrophage liver X receptors (LXRs). However, systemic activation of LXRs triggers excessive lipogenesis in the liver and infusion of HDL downregulates cholesterol efflux from macrophages. Here we describe an enlightened strategy using phospholipid reconstituted apoA-I peptide (22A)-derived synthetic HDL (sHDL) to deliver LXR agonists to the atheroma and examine their effect on atherosclerosis regression in vivo...
December 20, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29344291/-in-vivo-double-targeting-of-c26-colon-carcinoma-cells-and-microenvironmental-protumor-processes-using-liposomal-simvastatin
#12
Lavinia Luput, Emilia Licarete, Denise Minerva Drotar, Andras-Laszlo Nagy, Alina Sesarman, Laura Patras, Valentin Florian Rauca, Alina Porfire, Dana Muntean, Marcela Achim, Ioan Tomuta, Laurian Vlase, Cornel Catoi, Nicolae Dragos, Manuela Banciu
Purpose: Besides cholesterol lowering effects, simvastatin (SIM) at very high doses possesses antitumor actions. Moreover our previous studies demonstrated that tumor-targeted delivery of SIM by using long-circulating liposomes (LCL) improved the therapeutic index of this drug in murine melanoma-bearing mice. To evaluate whether this finding can be exploited for future therapy of colorectal cancer the antitumor activity and the underlying mechanisms of long-circulating liposomal simvastatin (LCL-SIM) efficacy for inhibition of C26 murine colon carcinoma growth in vivo were investigated...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29334784/unilateral-lag-screw-fixation-of-isolated-non-union-atlas-lateral-mass-fracture-a-new-technical-note
#13
Majid Reza Farrokhi, Arash Kiani, Hamid Rezaei
We describe a novel and new technique of posterior unilateral lag screw fixation of non-union atlas lateral mass fracture. A 46-year-old man presented with cervical pain and tenderness after a vehicle turn over accident and he was diagnosed to have left atlas lateral mass fracture. He was initially treated by immobilization using Minerva orthosis. About 2 months later, he developed severe neck pain and limitation of motion and thus he was scheduled for operation due to non-union atlas lateral mass fracture...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29334428/development-of-potent-inhibitors-of-the-mycobacterium-tuberculosis-virulence-factor-zmp1-and-evaluation-of-their-effect-on-mycobacterial-survival-inside-macrophages
#14
Marco Paolino, Margherita Brindisi, Alessandra Vallone, Stefania Butini, Giusepp Campiani, Chiara Nannicini, Germano Giuliani, Maurizio Anzini, Stefania Lamponi, Gianluca Giorgi, Diego Sbardella, Davide M Ferraris, Stefano Marini, Massimo Coletta, Ivana Palucci, Mariachiara Minerva, Giovanni Delogu, Ilaria Pepponi, Delia Goletti, Andrea Cappelli, Sandra Gemma, Simone Brogi
The enzyme Zmp1 is a zinc-peptidase having a critical role in M. tuberculosis pathogenicity. Here we describe the identification of a small set of Zmp1 inhibitors based on a novel 8-hydroxyquinoline-2-hydroxamate scaffold. Among the synthesized compounds, 1c was the most potent Zmp1 inhibitor known to date, and its binding mode was analysed both through kinetic studies and molecular modelling, identifying critical interactions of 1c with the zinc-ion and residues in the active site. Effect of 1c on intracellular Mycobacterium survival was assayed in J774 murine macrophages infected with M...
January 15, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29334215/a-year-in-review-in-minerva-anestesiologica-2017-critical-care-experimental-and-clinical-studies
#15
Franco Cavaliere, Gianni Biancofiore, Elena Bignami, Edoardo DE Robertis, Alberto Giannini, Salvatore Grasso, Marco Piastra, Sabino Scolletta, Fabio S Taccone, Pierpaolo Terragni
No abstract text is available yet for this article.
January 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29325603/culture-conditions-affect-ca2-release-in-artificially-activated-mouse-and-human-oocytes
#16
Yuechao Lu, Davina Bonte, Minerva Ferrer-Buitrago, Mina Popovic, Jitesh Neupane, Margot Van der Jeught, Luc Leybaert, Petra De Sutter, Björn Heindryckx
Inconsistent fertilisation and pregnancy rates have been reported by different laboratories after application of ionomycin as a clinical method of assisted oocyte activation (AOA) to overcome fertilisation failure. Using both mouse and human oocytes, in the present study we investigated the effects of ionomycin and Ca2+ concentrations on the pattern of Ca2+ release and embryonic developmental potential. In the mouse, application of 5μM ionomycin in potassium simplex optimisation medium (KSOM) or 10µM ionomycin in Ca2+-free KSOM significantly reduced the Ca2+ flux and resulted in failure of blastocyst formation compared with 10μM ionomycin in KSOM...
January 12, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29306965/differential-activation-of-arginine-vasopressin-receptor-subtypes-in-the-amygdaloid-modulation-of-anxiety-in-the-rat-by-arginine-vasopressin
#17
Oscar René Hernández-Pérez, Minerva Crespo-Ramírez, Yordanka Cuza-Ferrer, José Anias-Calderón, Limei Zhang, Gabriel Roldan-Roldan, Raúl Aguilar-Roblero, Dasiel O Borroto-Escuela, Kjell Fuxe, Miguel Perez de la Mora
RATIONALE: The amygdala plays a paramount role in the modulation of anxiety and numerous studies have shown that arginine vasopressin (AVP) elicits anxiogenic effects following either its systemic or septal administration. OBJECTIVES: The aim of this paper was to study the involvement of vasopressinergic neurotransmission in the amygdaloid modulation of unconditioned anxiety and to ascertain whether or not AVP receptor subtypes may have a differential role in this modulation...
January 7, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29276420/effects-of-minerva-orthosis-on-larynx-height-in-young-healthy-volunteers
#18
Pegah Saddat Hosseini, Mohammad Taghi Karimi, Saeideh Moayedfar, Marzieh Golabbakhsh, Fatemeh Abnavi
Background: During speech, larynx is higher in the neck for high-pitched sounds and lower for low-pitched sounds. Patients with different problems in cervical and cervicothoracic spine use cervical orthosis to limit cervical motion. This study aimed to evaluate the effects of Minerva orthosis on larynx height in young, healthy volunteers. Subjects and methods: This study included 18 subjects. Acoustic measurement of frequency variability has been assessed in 3 brace conditions: (1) without brace, (2) with brace, and (3) 30 minutes after wearing the brace...
2017: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29246501/multiethnic-study-of-breast-arterial-calcium-gradation-and-cardiovascular-disease-cohort-recruitment-and-baseline-characteristics
#19
Carlos Iribarren, Gabriela Sanchez, Gail Husson, Tory Levine-Hall, Charles Quesenberry, Danny L Sam, Joetta Maier, Rakesh S Chaudhary, Minal Patel, Bahman Sadeghi, Hanna Javan, Hyo-Min Cho, Huanjun Ding, Sabee Molloi
PURPOSE: MultIethNic Study of BrEast ARterial Calcium Gradation and CardioVAscular Disease (MINERVA) was designed to answer the question of whether a novel continuous breast arterial calcification (BAC) mass score improves cardiovascular risk stratification among asymptomatic postmenopausal women. This article describes recruitment and baseline characteristics. METHODS: MINERVA is a multiethnic longitudinal cohort study. The phenotype data include BAC mass by densitometry applied to digital mammograms, sociodemographic factors, self-reported medical history, medications, parental history, reproductive history, smoking, alcohol consumption, physical activity, anthropometry, ankle-brachial index, blood pressure, laboratory panel, breast volumes, cognitive function, bioelectrical impedance, habitual diet, dietary supplements, sleep, psychosocial factors, and sun exposure...
December 5, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29218429/protein-expression-of-pttg1-as-a-diagnostic-biomarker-in-adrenocortical-carcinoma
#20
Minerva Angélica Romero Arenas, Timothy G Whitsett, Anna Aronova, Samuel A Henderson, Janine LoBello, Mouhammed Amir Habra, Elizabeth G Grubbs, Jeffrey E Lee, Kanishka Sircar, Rasa Zarnegar, Theresa Scognamiglio, Thomas J Fahey, Nancy D Perrier, Michael J Demeure
BACKGROUND: Adrenocortical carcinoma (ACC) has a poor prognosis and there is an unmet clinical need for biomarkers to improve both diagnostic and prognostic assessment. Pituitary-tumor transforming gene (PTTG1) has been shown to modulate cancer invasiveness and response to therapy. The potential role of PTTG1 protein levels in ACC has not been previously addressed. We assessed whether increased nuclear protein expression of PTTG1 distinguished ACCs from adrenocortical adenomas (ACAs)...
December 7, 2017: Annals of Surgical Oncology
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