keyword
MENU ▼
Read by QxMD icon Read
search

Minerva

keyword
https://www.readbyqxmd.com/read/29053055/successful-surgical-repair-and-recovery-in-a-2-week-old-infant-after-birth-related-cervical-fracture-dislocation
#1
Sara Saleh, Kyle I Swanson, Taryn Bragg
Cervical spine injuries are the most common spine injuries in the pediatric population. The authors present the youngest known patient who underwent cervical spine fusion to repair birth trauma-induced cervical fracture dislocation, resulting in spondyloptosis and spinal cord injury. A 2-week-old boy was found to have spondyloptosis and spinal cord injury after concerns arose from reduced movement of the extremities. The patient's birth was complicated by undiagnosed abdominal dystocia, which led to cervical distraction injury...
October 20, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29032366/from-assistive-to-enhancing-technology-should-the-treatment-enhancement-distinction-apply-to-future-assistive-and-augmenting-technologies
#2
Francesca Minerva, Alberto Giubilini
The treatment-enhancement distinction is often used to delineate acceptable and unacceptable medical interventions. It is likely that future assistive and augmenting technologies will also soon develop to a level that they might be considered to provide users, in particular those with disabilities, with abilities that go beyond natural human limits, and become in effect an enhancing technology. In this paper, we describe how this process might take place, and discuss the moral implications of such developments...
October 14, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28980212/injectable-facial-fillers-imaging-features-complications-and-diagnostic-pitfalls-at-mri-and-pet-ct
#3
REVIEW
Pravin Mundada, Romain Kohler, Sana Boudabbous, Laurence Toutous Trellu, Alexandra Platon, Minerva Becker
Injectable fillers are widely used for facial rejuvenation, correction of disabling volumetric fat loss in HIV-associated facial lipoatrophy, Romberg disease, and post-traumatic facial disfiguring. The purpose of this article is to acquaint the reader with the anatomy of facial fat compartments, as well as with the properties and key imaging features of commonly used facial fillers, filler-related complications, interpretation pitfalls, and dermatologic conditions mimicking filler-related complications. The distribution of facial fillers is characteristic and depends on the anatomy of the superficial fat compartments...
October 4, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28972100/actinomycetoma-a-therapeutic-challenge
#4
Sylvia Aide Martínez-Cabriales, Jorge Ocampo-Candiani, Esperanza Welsh, Ana Sofía Ayala-Cortés, Minerva Gómez-Flores, Oliverio Welsh
No abstract text is available yet for this article.
September 29, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28968937/lipid-metabolism-and-pro-oxidant-antioxidant-balance-of-halamphora-oceanica-from-the-gulf-of-mexico-exposed-to-water-accommodated-fraction-of-maya-crude-oil
#5
Hugo F Olivares-Rubio, Lucía Salazar-Coria, Minerva Nájera-Martínez, José Luis Godínez-Ortega, Armando Vega-López
Diatoms play key roles in primary production and carbon fixation at a global scale and in some cases these species live on marine ecosystems impacted by crude oil (CO) spills. Halamphora oceanica, a new diatom species from the Southwest of the Gulf of Mexico was isolated and cultured in the laboratory and was exposed to water accommodated fraction (WAF) of different Maya CO loads at 0.01, 0.1, 1 and 10g/L by 96h. A battery of biomarkers involved in oxidative stress (O2•, H2O2, TBARS, ROOH, RC=O, SOD, CAT, GPx), biotransformation and conjugation (total CYP450 activity and GST) moreover fatty acid (FA) metabolism (FA levels, fatty-acid synthase and acyl-CoA oxidase) were measured...
September 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28952766/direct-measurement-of-nuclear-dependence-of-charged-current-quasielasticlike-neutrino-interactions-using-minerva
#6
M Betancourt, A Ghosh, T Walton, O Altinok, L Bellantoni, A Bercellie, A Bodek, A Bravar, T Cai, D A Martinez Caicedo, M F Carneiro, S A Dytman, G A Díaz, J Felix, L Fields, R Fine, R Galindo, H Gallagher, A Ghosh, T Golan, R Gran, D A Harris, A Higuera, K Hurtado, M Kiveni, J Kleykamp, T Le, E Maher, S Manly, W A Mann, C M Marshall, K S McFarland, C L McGivern, A M McGowan, B Messerly, J Miller, A Mislivec, J G Morfín, J Mousseau, D Naples, J K Nelson, A Norrick, Nuruzzaman, C E Patrick, G N Perdue, M A Ramírez, L Ren, D Rimal, P A Rodrigues, D Ruterbories, H Schellman, J T Sobczyk, C J Solano Salinas, S Sánchez Falero, E Valencia, J Wolcott, M Wospakrik, B Yaeggy
Charged-current ν_{μ} interactions on carbon, iron, and lead with a final state hadronic system of one or more protons with zero mesons are used to investigate the influence of the nuclear environment on quasielasticlike interactions. The transferred four-momentum squared to the target nucleus, Q^{2}, is reconstructed based on the kinematics of the leading proton, and differential cross sections versus Q^{2} and the cross-section ratios of iron, lead, and carbon to scintillator are measured for the first time in a single experiment...
August 25, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28952381/discovery-methods-of-coagulation-inhibiting-drugs
#7
Antonio Gómez-Outes, Minerva García-Fuentes, Mª Luisa Suárez-Gea
In the last decade, several direct oral anticoagulants (DOAC) targeting thrombin (dabigatran) or activated factor X (FXa) (rivaroxaban, apixaban and edoxaban) have been marketed for a number of indications related to prophylaxis and treatment of thrombotic diseases. All these drugs are effective in preventing thrombosis, but are associated with an increased bleeding risk. Areas covered: This review includes a summary of new targets for anticoagulation (e.g.: FXIa, FXIIa, protein disulfide isomerase, polyphosphates, etc...
September 27, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28919999/first-report-of-clinical-responses-to-immunotherapy-in-3-relapsing-cases-of-chordoma-after-failure-of-standard-therapies
#8
Denis Migliorini, Nicolas Mach, Diego Aguiar, Rémi Vernet, Basile Nicolas Landis, Minerva Becker, Thomas McKee, Valérie Dutoit, Pierre-Yves Dietrich
Chordoma is a rare tumor of notochordal origin, currently principally treated by surgery and/or irradiation. Here, we describe the clinical outcome of 3 consecutive patients with metastatic and locally advanced chordoma, treated with different immunotherapeutic approaches. All patients presented fast growing tumors and failure of standard therapies. One was treated with a tumor-based vaccine, the 2 others with anti-PD1 antibodies, all with impressive clinical and radiological responses. We therefore propose that chordoma is an immunogenic tumor and thus that translational and clinical research is necessary to develop rationally designed immunotherapy approaches...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28911035/evaluation-of-pe_pgrs33-as-a-potential-surface-target-for-humoral-responses-against-mycobacterium-tuberculosis
#9
Mariachiara Minerva, Flavio De Maio, Serena Camassa, Basem Battah, Palucci Ivana, Riccardo Manganelli, Maurizio Sanguinetti, Michela Sali, Giovanni Delogu
Mycobacterium tuberculosis (Mtb) PE_PGRS33 is a surface-exposed protein that was shown to interact with Toll-like receptor 2 on host macrophages to induce inflammatory signals and promote entry in macrophages. In this study, we investigated PE_PGRS33 as a potential target of a humoral response aimed at hampering key processes in tuberculosis pathogenesis. PE_PGRS33 protein was successfully expressed and purified under native condition in Escherichia coli. The purified protein retained its native functional and biological properties, showing the ability to elicit proinflammatory signals in murine and human macrophages...
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28892582/study-on-the-tumor-induced-angiogenesis-using-mathematical-models
#10
REVIEW
Takashi Suzuki, Dhisa Minerva, Koichi Nishiyama, Naohiko Koshikawa, Mark Andrew Joseph Chaplain
We study angiogenesis using mathematical models describing the dynamics of tip cells. We review the basic ideas of angiogenesis models and its numerical simulation technique to produce realistic computer graphics images of sprouting angiogenesis. We examine the classical model of Anderson-Chaplain using fundamental concepts of mass transport and chemical reaction with ECM degradation included. Then we construct two kind of numerical schemes, model-faithful and model-driven ones, where new techniques of numerical simulation are introduced, such as the transient probability, particle velocity, and Boolean variables...
September 11, 2017: Cancer Science
https://www.readbyqxmd.com/read/28870866/evaluation-of-the-effect-of-an-environmental-management-program-on-exposure-to-manganese-in-a-mining-zone-in-mexico
#11
Marlene Cortez-Lugo, Hortensia Moreno Macías, Sergio Montes, Yaneth Rodríguez Agudelo, David Hernández Bonilla, Minerva Catalán-Vázquez, Raúl Díaz Godoy, Sandra Leticia Rodríguez Dozal
BACKGROUND: In the state of Hidalgo, Mexico, is found the largest second deposit of Manganese (Mn) in Latin America. Various studies on the sources of emission, exposure, and the effects on the health of children and adults have been conducted utilizing an ecosystem approach. Given the findings of Mn levels in air and the neurocognitive effects, an Environmental Management Program (EMP) was designed and implemented with the purpose of reducing exposure to Mn of the population, including various actions for reducing Mn emissions into the atmosphere...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28870247/seropositivity-for-trypanosoma-cruzi-in-domestic-dogs-from-sonora-mexico
#12
Minerva Arce-Fonseca, Silvia C Carrillo-Sánchez, Ramón M Molina-Barrios, Mariana Martínez-Cruz, Jesús R Cedillo-Cobián, Yuly A Henao-Díaz, Olivia Rodríguez-Morales
BACKGROUND: Chagas disease is an important health problem in Latin America due to its incapacitating effects and associated mortality. Studies on seropositivity for Trypanosoma cruzi in Mexican dogs have demonstrated a direct correlation between seropositivity in humans and dogs, which can act as sentinels for the disease in this region. The objective of this study was to determine the seropositivity for T.cruzi infection in dogs from Sonora, a northern borderstate of Mexico. METHODS: Responsible pet owners were selected at random from an urban area of Empalme municipality, Sonora, Mexico, and from there, 180 dog samples were collected...
September 5, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28853561/simultaneous-electrochemical-speciation-of-oxidized-and-reduced-glutathione-redox-profiling-of-oxidative-stress-in-biological-fluids-with-a-modified-carbon-electrode
#13
Patricia M Olmos Moya, Minerva Martínez Alfaro, Rezvan Kazemi, Mario A Alpuche-Avilés, Sophie Griveau, Fethi Bedioui, Silvia Gutiérrez Granados
The simultaneous electrochemical quantification of oxidized (GSSG) and reduced glutathione (GSH), biomarkers of oxidative stress, is demonstrated in biological fluids. The detection was accomplished by the development of a modified carbon electrode and was applied to the analysis of biological fluids of model organisms under oxidative stress caused by lead intoxication. Nanocomposite molecular material based on cobalt phthalocyanine (CoPc) and multiwalled carbon nanotubes functionalized with carboxyl groups (MWCNTf) was developed to modify glassy carbon electrodes (GCE) for the detection of reduced and oxidized glutathione...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28840128/calcium-phosphate-product-is-associated-with-subclinical-carotid-atherosclerosis-in-type-2-diabetes
#14
Anna Ramírez-Morros, Minerva Granado-Casas, Nuria Alcubierre, Montserrat Martinez-Alonso, Jordi Real, Esmeralda Castelblanco, Aureli Esquerda, Gonzalo Cao, Esther Rubinat, Marta Hernández, Núria Alonso, Elvira Fernández, Didac Mauricio
AIMS: To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease. METHODS: We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28812148/local-recurrence-of-squamous-cell-carcinoma-of-the-head-and-neck-after-radio-chemo-therapy-diagnostic-performance-of-fdg-pet-mri-with-diffusion-weighted-sequences
#15
Minerva Becker, Arthur D Varoquaux, Christophe Combescure, Olivier Rager, Marc Pusztaszeri, Karim Burkhardt, Bénédicte M A Delattre, Pavel Dulguerov, Nicolas Dulguerov, Eirini Katirtzidou, Francesca Caparrotti, Osman Ratib, Habib Zaidi, Christoph D Becker
PURPOSE: To determine the diagnostic performance of FDG-PET/MRI with diffusion-weighted imaging (FDG-PET/DWIMRI) for detection and local staging of head and neck squamous cell carcinoma (HNSCC) after radio(chemo)therapy. MATERIALS AND METHODS: This was a prospective study that included 74 consecutive patients with previous radio(chemo)therapy for HNSCC and in whom tumour recurrence or radiation-induced complications were suspected clinically. The patients underwent hybrid PET/MRI examinations with morphological MRI, DWI and FDG-PET...
August 15, 2017: European Radiology
https://www.readbyqxmd.com/read/28750634/preclinical-carotid-atherosclerosis-in-patients-with-latent-autoimmune-diabetes-in-adults-lada-type-2-diabetes-and-classical-type-1-diabetes
#16
Marta Hernández, Carolina López, Jordi Real, Joan Valls, Emilio Ortega-Martinez de Victoria, Federico Vázquez, Esther Rubinat, Minerva Granado-Casas, Nuria Alonso, Teresa Molí, Angels Betriu, Albert Lecube, Elvira Fernández, Richard David Leslie, Dídac Mauricio
BACKGROUND: LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. METHODS: Patients with LADA were matched for age and gender in different proportions to patients with type 2 diabetes, and classic type 1 diabetes...
July 28, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28735381/characterization-of-the-sensorimotor-rhythm-in-4-month-old-infants-born-at-term-and-premature
#17
Milene Roca-Stappung, Minerva Moguel-González, Thalía Fernández, Thalía Harmony, Omar Mendoza-Montoya, José Luis Marroquín, Salvador Ruiz-Correa, Lourdes Díaz-Comas, Gloria Otero-Ojeda
The sensorimotor rhythm (SMR) is an electroencephalographic rhythm associated with motor and cognitive development observed in the central brain regions during wakefulness in the absence of movement, and it reacts contralaterally to generalized and hemibody movements. The purpose of this work was to characterize the SMR of 4-month-old infants, born either healthy at term or prematurely with periventricular leukomalacia (PVL). Two groups of infants were formed: healthy and premature with PVL. Their electroencephalograms (EEGs) were recorded in four conditions: rest, free movement, right-hand grasping and left-hand grasping, in order to explore general reactivity to free movement and contralateral reactivity in hand-grasping conditions...
July 22, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28732550/epidemiology-of-taeniosis-cysticercosis-in-europe-a-systematic-review-western-europe
#18
REVIEW
Minerva Laranjo-González, Brecht Devleesschauwer, Chiara Trevisan, Alberto Allepuz, Smaragda Sotiraki, Annette Abraham, Mariana Boaventura Afonso, Joachim Blocher, Luís Cardoso, José Manuel Correia da Costa, Pierre Dorny, Sarah Gabriël, Jacinto Gomes, María Ángeles Gómez-Morales, Pikka Jokelainen, Miriam Kaminski, Brane Krt, Pascal Magnussen, Lucy J Robertson, Veronika Schmidt, Erich Schmutzhard, G Suzanne A Smit, Barbara Šoba, Christen Rune Stensvold, Jože Starič, Karin Troell, Aleksandra Vergles Rataj, Madalena Vieira-Pinto, Manuela Vilhena, Nicola Ann Wardrop, Andrea S Winkler, Veronique Dermauw
BACKGROUND: Taenia solium and Taenia saginata are zoonotic parasites of public health importance. Data on their occurrence in humans and animals in western Europe are incomplete and fragmented. In this study, we aimed to update the current knowledge on the epidemiology of these parasites in this region. METHODS: We conducted a systematic review of scientific and grey literature published from 1990 to 2015 on the epidemiology of T. saginata and T. solium in humans and animals...
July 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28731762/measurement-of-neutral-current-k-production-by-neutrinos-using-minerva
#19
C M Marshall, L Aliaga, O Altinok, L Bellantoni, A Bercellie, M Betancourt, A Bodek, A Bravar, T Cai, M F Carneiro, H da Motta, S A Dytman, G A Díaz, M Dunkman, B Eberly, E Endress, J Felix, L Fields, R Fine, A M Gago, R Galindo, H Gallagher, A Ghosh, T Golan, R Gran, D A Harris, A Higuera, K Hurtado, J Kleykamp, M Kordosky, T Le, E Maher, S Manly, W A Mann, D A Martinez Caicedo, K S McFarland, C L McGivern, A M McGowan, B Messerly, J Miller, A Mislivec, J G Morfín, J Mousseau, D Naples, J K Nelson, A Norrick, Nuruzzaman, V Paolone, C E Patrick, G N Perdue, M A Ramírez, R D Ransome, H Ray, L Ren, D Rimal, P A Rodrigues, D Ruterbories, D W Schmitz, C J Solano Salinas, M Sultana, S Sánchez Falero, E Valencia, T Walton, J Wolcott, M Wospakrik, B Yaeggy, D Zhang
Neutral-current production of K^{+} by atmospheric neutrinos is a background in searches for the proton decay p→K^{+}ν[over ¯]. Reactions such as νp→νK^{+}Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K^{+} are identified in MINERvA by reconstructing the timing signature of a K^{+} decay at rest. A sample of 201 neutrino-induced neutral-current K^{+} events is used to measure differential cross sections with respect to the K^{+} kinetic energy, and the non-K^{+} hadronic visible energy...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28714976/rare-coding-variants-in-plcg2-abi3-and-trem2-implicate-microglial-mediated-innate-immunity-in-alzheimer-s-disease
#20
Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis, Eden R Martin, Benjamin Grenier-Boley, Stefanie Heilmann-Heimbach, Vincent Chouraki, Amanda B Kuzma, Kristel Sleegers, Maria Vronskaya, Agustin Ruiz, Robert R Graham, Robert Olaso, Per Hoffmann, Megan L Grove, Badri N Vardarajan, Mikko Hiltunen, Markus M Nöthen, Charles C White, Kara L Hamilton-Nelson, Jacques Epelbaum, Wolfgang Maier, Seung-Hoan Choi, Gary W Beecham, Cécile Dulary, Stefan Herms, Albert V Smith, Cory C Funk, Céline Derbois, Andreas J Forstner, Shahzad Ahmad, Hongdong Li, Delphine Bacq, Denise Harold, Claudia L Satizabal, Otto Valladares, Alessio Squassina, Rhodri Thomas, Jennifer A Brody, Liming Qu, Pascual Sánchez-Juan, Taniesha Morgan, Frank J Wolters, Yi Zhao, Florentino Sanchez Garcia, Nicola Denning, Myriam Fornage, John Malamon, Maria Candida Deniz Naranjo, Elisa Majounie, Thomas H Mosley, Beth Dombroski, David Wallon, Michelle K Lupton, Josée Dupuis, Patrice Whitehead, Laura Fratiglioni, Christopher Medway, Xueqiu Jian, Shubhabrata Mukherjee, Lina Keller, Kristelle Brown, Honghuang Lin, Laura B Cantwell, Francesco Panza, Bernadette McGuinness, Sonia Moreno-Grau, Jeremy D Burgess, Vincenzo Solfrizzi, Petra Proitsi, Hieab H Adams, Mariet Allen, Davide Seripa, Pau Pastor, L Adrienne Cupples, Nathan D Price, Didier Hannequin, Ana Frank-García, Daniel Levy, Paramita Chakrabarty, Paolo Caffarra, Ina Giegling, Alexa S Beiser, Vilmantas Giedraitis, Harald Hampel, Melissa E Garcia, Xue Wang, Lars Lannfelt, Patrizia Mecocci, Gudny Eiriksdottir, Paul K Crane, Florence Pasquier, Virginia Boccardi, Isabel Henández, Robert C Barber, Martin Scherer, Lluis Tarraga, Perrie M Adams, Markus Leber, Yuning Chen, Marilyn S Albert, Steffi Riedel-Heller, Valur Emilsson, Duane Beekly, Anne Braae, Reinhold Schmidt, Deborah Blacker, Carlo Masullo, Helena Schmidt, Rachelle S Doody, Gianfranco Spalletta, W T Longstreth Jr, Thomas J Fairchild, Paola Bossù, Oscar L Lopez, Matthew P Frosch, Eleonora Sacchinelli, Bernardino Ghetti, Qiong Yang, Ryan M Huebinger, Frank Jessen, Shuo Li, M Ilyas Kamboh, John Morris, Oscar Sotolongo-Grau, Mindy J Katz, Chris Corcoran, Melanie Dunstan, Amy Braddel, Charlene Thomas, Alun Meggy, Rachel Marshall, Amy Gerrish, Jade Chapman, Miquel Aguilar, Sarah Taylor, Matt Hill, Mònica Díez Fairén, Angela Hodges, Bruno Vellas, Hilkka Soininen, Iwona Kloszewska, Makrina Daniilidou, James Uphill, Yogen Patel, Joseph T Hughes, Jenny Lord, James Turton, Annette M Hartmann, Roberta Cecchetti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Carlo Caltagirone, Maria Donata Orfei, Antonio Ciaramella, Sabrina Pichler, Manuel Mayhaus, Wei Gu, Alberto Lleó, Juan Fortea, Rafael Blesa, Imelda S Barber, Keeley Brookes, Chiara Cupidi, Raffaele Giovanni Maletta, David Carrell, Sandro Sorbi, Susanne Moebus, Maria Urbano, Alberto Pilotto, Johannes Kornhuber, Paolo Bosco, Stephen Todd, David Craig, Janet Johnston, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Nick C Fox, John Hardy, Roger L Albin, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Clinton T Baldwin, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Eileen H Bigio, Thomas D Bird, Bradley F Boeve, James D Bowen, Adam Boxer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Chuanhai Cao, Chris S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Carolina Ceballos Diaz, Helena C Chui, David G Clark, David H Cribbs, Elizabeth A Crocco, Charles DeCarli, Malcolm Dick, Ranjan Duara, Denis A Evans, Kelley M Faber, Kenneth B Fallon, David W Fardo, Martin R Farlow, Steven Ferris, Tatiana M Foroud, Douglas R Galasko, Marla Gearing, Daniel H Geschwind, John R Gilbert, Neill R Graff-Radford, Robert C Green, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Lawrence S Honig, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Gail P Jarvik, Erin Abner, Lee-Way Jin, Gyungah Jun, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Neil W Kowall, Joel H Kramer, Frank M LaFerla, James J Lah, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Kathryn L Lunetta, Constantine G Lyketsos, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, John C Morris, Jill R Murrell, Amanda J Myers, Sid O'Bryant, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Henry L Paulson, William Perry, Elaine Peskind, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, Christiane Reitz, John M Ringman, Erik D Roberson, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Mark A Sager, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Rudolph E Tanzi, Tricia A Thornton-Wells, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Fabienne Garzia, Feroze Golamaully, Gislain Septier, Sebastien Engelborghs, Rik Vandenberghe, Peter P De Deyn, Carmen Muñoz Fernadez, Yoland Aladro Benito, Hakan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult-Stählbom, Lena Kilander, RoseMarie Brundin, Letizia Concari, Seppo Helisalmi, Anne Maria Koivisto, Annakaisa Haapasalo, Vincent Dermecourt, Nathalie Fievet, Olivier Hanon, Carole Dufouil, Alexis Brice, Karen Ritchie, Bruno Dubois, Jayanadra J Himali, C Dirk Keene, JoAnn Tschanz, Annette L Fitzpatrick, Walter A Kukull, Maria Norton, Thor Aspelund, Eric B Larson, Ron Munger, Jerome I Rotter, Richard B Lipton, María J Bullido, Albert Hofman, Thomas J Montine, Eliecer Coto, Eric Boerwinkle, Ronald C Petersen, Victoria Alvarez, Fernando Rivadeneira, Eric M Reiman, Maura Gallo, Christopher J O'Donnell, Joan S Reisch, Amalia Cecilia Bruni, Donald R Royall, Martin Dichgans, Mary Sano, Daniela Galimberti, Peter St George-Hyslop, Elio Scarpini, Debby W Tsuang, Michelangelo Mancuso, Ubaldo Bonuccelli, Ashley R Winslow, Antonio Daniele, Chuang-Kuo Wu, Oliver Peters, Benedetta Nacmias, Matthias Riemenschneider, Reinhard Heun, Carol Brayne, David C Rubinsztein, Jose Bras, Rita Guerreiro, Ammar Al-Chalabi, Christopher E Shaw, John Collinge, David Mann, Magda Tsolaki, Jordi Clarimón, Rebecca Sussams, Simon Lovestone, Michael C O'Donovan, Michael J Owen, Timothy W Behrens, Simon Mead, Alison M Goate, Andre G Uitterlinden, Clive Holmes, Carlos Cruchaga, Martin Ingelsson, David A Bennett, John Powell, Todd E Golde, Caroline Graff, Philip L De Jager, Kevin Morgan, Nilufer Ertekin-Taner, Onofre Combarros, Bruce M Psaty, Peter Passmore, Steven G Younkin, Claudine Berr, Vilmundur Gudnason, Dan Rujescu, Dennis W Dickson, Jean-François Dartigues, Anita L DeStefano, Sara Ortega-Cubero, Hakon Hakonarson, Dominique Campion, Merce Boada, John Keoni Kauwe, Lindsay A Farrer, Christine Van Broeckhoven, M Arfan Ikram, Lesley Jones, Jonathan L Haines, Christophe Tzourio, Lenore J Launer, Valentina Escott-Price, Richard Mayeux, Jean-François Deleuze, Najaf Amin, Peter A Holmans, Margaret A Pericak-Vance, Philippe Amouyel, Cornelia M van Duijn, Alfredo Ramirez, Li-San Wang, Jean-Charles Lambert, Sudha Seshadri, Julie Williams, Gerard D Schellenberg
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10(-4)) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10(-8)) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p...
September 2017: Nature Genetics
keyword
keyword
59372
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"