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https://www.readbyqxmd.com/read/28073868/delayed-diagnosis-of-fractured-anterior-arch-of-the-atlas-in-a-young-child
#1
Sergio B Sesia, Friederike Prüfer, Michael Walther, Daniel Studer
A 2-year-old girl fell off a bunk bed onto a parquet floor. She immediately reported neck pain and presented with muscle spasm and limited motion of the cervical spine (C-spine). Plain X-rays of the C-spine showed no osseous lesion. Owing to persisting pain and limited motion in the neck, MRI of the C-spine was obtained which revealed intact ligaments and cervical spinal cord, as well as soft tissue swelling in front of the anterior arch of the atlas. Subsequent CT of the C-spine confirmed a complete, undisplaced fracture of the anterior arch of the atlas (Gehweiler type I fracture)...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28053907/prevalence-of-osteonecrosis-of-the-jaw-and-oral-characteristics-of-oncologic-patients-treated-with-bisphosphonates-at-the-general-hospital-of-mexico
#2
María Verónica Cuevas-González, Celia Minerva Díaz-Aguirre, Enrique Echevarría-Y-Pérez, Juan Carlos Cuevas-González
OBJECTIVES: To determine the prevalence and oral characteristics of cancer patients treated with bisphosphonates in the oncology and maxillofacial prosthesis departments of the General Hospital of Mexico between 2011 and 2013. MATERIALS AND METHODS: This cross-sectional study included patients who received prior treatment with bisphosphonates; an intraoral examination was performed by 2 standardized examiners. RESULTS: The prevalence of bisphosphonate-related necrosis in 75 patients was 2...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28012078/odontoid-osteomyelitis-with-atlantoaxial-subluxation-in-an-infant
#3
Hoon Park, Hyung Kwon Byeon, Hak-Sun Kim, Jung Jun Hong, Kyung-Soo Suk
PURPOSE: To report a rare case of odontoid osteomyelitis with atlantoaxial subluxation in a 6-month-old infant. BACKGROUND: Odontoid osteomyelitis with atlantoaxial subluxation is extremely rare in children. Although several cases have been reported, there have been no studies concerning proper surgical drainage and immobilization in this disease. METHODS: A 6-month-old infant with odontoid osteomyelitis with atlantoaxial subluxation was surgically treated...
December 23, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28008639/the-invisible-discrimination-before-our-eyes-a-bioethical-analysis
#4
Francesca Minerva
The goal of this article is to introduce a philosophical analysis of a widely neglected condition which affects between 3% and 18% of the population. People affected by this condition (which will be revealed later in the article) experience a lower level of wellbeing than the average population and are discriminated against in both their professional and their personal life. I will argue that this form of discrimination should be taken more seriously in philosophical debate and that social, legal and medical measures ought to be taken in order to improve the quality of life of people affected by this condition...
December 23, 2016: Bioethics
https://www.readbyqxmd.com/read/27939925/a-candidate-regulatory-variant-at-the-trem-gene-cluster-associates-with-decreased-alzheimer-s-disease-risk-and-increased-treml1-and-trem2-brain-gene-expression
#5
Minerva M Carrasquillo, Mariet Allen, Jeremy D Burgess, Xue Wang, Samantha L Strickland, Shivani Aryal, Joanna Siuda, Michaela L Kachadoorian, Christopher Medway, Curtis S Younkin, Asha Nair, Chen Wang, Pritha Chanana, Daniel Serie, Thuy Nguyen, Sarah Lincoln, Kimberly G Malphrus, Kevin Morgan, Todd E Golde, Nathan D Price, Charles C White, Philip L De Jager, David A Bennett, Yan W Asmann, Julia E Crook, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner
INTRODUCTION: We hypothesized that common Alzheimer's disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression. METHODS: Expression microarrays on temporal cortex and cerebellum from ∼400 neuropathologically diagnosed subjects and two independent RNAseq replication cohorts were used for expression quantitative trait locus analysis. RESULTS: A variant within a DNase hypersensitive site 5' of TREM2, rs9357347-C, associates with reduced AD risk and increased TREML1 and TREM2 levels (uncorrected P = 6...
December 8, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27934572/conscientious-objection-complicity-in-wrongdoing-and-a-not-so-moderate-approach
#6
Francesca Minerva
This article analyzes the problem of complicity in wrongdoing in the case of healthcare practitioners (and in particular Roman Catholic ones) who refuse to perform abortions, but who are nonetheless required to facilitate abortions by informing their patients about this option and by referring them to a willing colleague. Although this solution is widely supported in the literature and is also widely represented in much legislation, the argument here is that it fails to both (1) safeguard the well-being of the patients, and (2) protect the moral integrity of healthcare practitioners...
January 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/27921251/skin-manifestations-of-insulin-resistance-from-a-biochemical-stance-to-a-clinical-diagnosis-and-management
#7
REVIEW
Gloria González-Saldivar, René Rodríguez-Gutiérrez, Jorge Ocampo-Candiani, José Gerardo González-González, Minerva Gómez-Flores
Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40-50% of the global population is labeled at "high risk" (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted...
December 5, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27857867/dna-methylation-signature-of-post-injury-neointimal-cells-during-vascular-remodeling-in-the-rat-balloon-injury-model
#8
Jendai Richards, Henry Ato Ogoe, Wenzhi Li, Oguljahan Babayewa, Wei Xu, Tameka Bythwood, Minerva Garcia-Barrios, Li Ma, Qing Song
Vascular smooth muscle cell (VSMC) accumulation in the neointimal is a common feature in vascular diseases such as atherosclerosis, transplant arteriosclerosis and restenosis. In this study, we isolated the neointimal cells and uninjured residential vascular smooth muscle cells by laser micro dissection and carried out single-cell whole-genome methylation sequencing. We also sequenced the bisulfite converted genome of circulating bone-marrow-derived cells such as peripheral blood mononuclear cells (PBMC) and bone marrow mononuclear cells (BMMC)...
July 2016: Molecular Biology (Los Angeles, Calif.)
https://www.readbyqxmd.com/read/27792697/-cutaneous-manifestations-in-inflammatory-bowel-disease
#9
Sonia Chavez-Álvarez, Minerva Gómez-Flores, Jorge Ocampo-Candiani
Inflammatory bowel disease (IBD), mainly chronic unspecific ulcerative colitis and Crohn's disease have increased in incidence in the last decades. These have multiple extraintestinal manifestations, with those of the skin appearing after the intestinal clinical presentation. These are classified as: granulomatous dermatosis, reactive dermatosis, and those secondary to treatment of IBD, and other dermatosis. This article presents the pathogenesis, clinical approach, treatment and expected evolution of these manifestations...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27760390/ms-imaging-and-mass-spectrometric-synaptosome-profiling-identify-pep-19-pcp4-as-a-synaptic-molecule-involved-in-spatial-learning-in-mice
#10
Jeroen Aerts, Annelies Laeremans, Laurens Minerva, Kurt Boonen, Budamgunta Harshavardhan, Rudi D'hooge, Dirk Valkenborg, Geert Baggerman, Lutgarde Arckens
The Morris water maze (MWM) spatial learning task has been demonstrated to involve a cognitive switch of action control to serve the transition from an early towards a late learning phase. However, the molecular mechanisms governing this switch are largely unknown. We employed MALDI MS imaging (MSI) to screen for changes in expression of small proteins in brain structures implicated in the different learning phases. We compared mice trained for 3days and 30days in the MWM, reflecting an early and a late learning phase in relation to the acquisition of a spatial learning task...
October 17, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27727239/human-whole-genome-genotype-and-transcriptome-data-for-alzheimer-s-and-other-neurodegenerative-diseases
#11
Mariet Allen, Minerva M Carrasquillo, Cory Funk, Benjamin D Heavner, Fanggeng Zou, Curtis S Younkin, Jeremy D Burgess, High-Seng Chai, Julia Crook, James A Eddy, Hongdong Li, Ben Logsdon, Mette A Peters, Kristen K Dang, Xue Wang, Daniel Serie, Chen Wang, Thuy Nguyen, Sarah Lincoln, Kimberly Malphrus, Gina Bisceglio, Ma Li, Todd E Golde, Lara M Mangravite, Yan Asmann, Nathan D Price, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner
Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human disease variants are enriched for polymorphisms that affect gene expression, including some that are known to associate with expression changes in the brain. Postulating that many variants confer risk to neurodegenerative disease via transcriptional regulatory mechanisms, we have analyzed gene expression levels in the brain tissue of subjects with AD and related diseases...
October 11, 2016: Scientific Data
https://www.readbyqxmd.com/read/27717058/pro-life-arguments-against-infanticide-and-why-they-are-not-convincing
#12
Joona Räsänen
Alberto Giubilini and Francesca Minerva's controversial article 'After-Birth Abortion: Why Should the Baby Live?' has received a lot of criticism since its publishing. Part of the recent criticism has been made by pro-life philosopher Christopher Kaczor, who argues against infanticide in his updated book 'Ethics of Abortion'. Kaczor makes four arguments to show where Giubilini and Minerva's argument for permitting infanticide goes wrong. In this article I argue that Kaczor's arguments, and some similar arguments presented by other philosophers, are mistaken and cannot show Giubilini and Minerva's view to be flawed...
November 2016: Bioethics
https://www.readbyqxmd.com/read/27708749/permanent-draft-genome-of-thermithiobaclillus-tepidarius-dsm-3134-t-a-moderately-thermophilic-obligately-chemolithoautotrophic-member-of-the-acidithiobacillia
#13
Rich Boden, Lee P Hutt, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, Tatiparthi Reddy, Chew Yee Ngan, Chris Daum, Nicole Shapiro, Victor Markowitz, Natalia Ivanova, Tanja Woyke, Nikos Kyrpides
Thermithiobacillus tepidarius DSM 3134(T) was originally isolated (1983) from the waters of a sulfidic spring entering the Roman Baths (Temple of Sulis-Minerva) at Bath, United Kingdom and is an obligate chemolithoautotroph growing at the expense of reduced sulfur species. This strain has a genome size of 2,958,498 bp. Here we report the genome sequence, annotation and characteristics. The genome comprises 2,902 protein coding and 66 RNA coding genes. Genes responsible for the transaldolase variant of the Calvin-Benson-Bassham cycle were identified along with a biosynthetic horseshoe in lieu of Krebs' cycle sensu stricto...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27703782/ketamine-stimulating-antidepressant-treatment
#14
Gin S Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A Frye, Michael Gitlin, Sidney H Kennedy, Terence A Ketter, Raymond W Lam, Rupert McShane, Alex J Mitchell, Michael J Ostacher, Sakina J Rizvi, Michael E Thase, Mauricio Tohen
SUMMARY: The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27696716/in-vitro-evaluation-of-apoptotic-effect-of-bis-acetylacetonato-k-2-o-o-1-10-phenanthroline-k-2-n-n-zn-ii-complex
#15
Cristina Trejo-Solis, Mayra A Alvarez-Lemus, Dolores Jiménez-Farfán, Isabel Anaya-Rubio, Rosendo López-González, Guadalupe Palencia, Dora M Frías-Márquez, Gerardo González-García, Carmen Rubio-Osornio, Minerva Calvillo-Velasco, Guadalupe Márquez-Chablé
Phenanthroline derivatives have been reported as potential bioactive compounds because of their ability to interact with DNA. In order to evaluate the antiproliferative effect of bis(acetylacetonate-k(2) O,O)(1,10-phenanthroline-k(2) N,N)Zn(II) or Zn(acac)2 (phen) complex, the compound was obtained in a simple manner and further characterized to determine crystal structure, thermal behavior, morphology and spectroscopic properties. The structure of the complex was confirmed by X-Ray single structure as well as by solution solid-state (13) C CP/MAS NMR...
October 2, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27693824/advanced-vessel-sealing-devices-in-total-thyroidectomy-for-substernal-goitre-a-retrospective-cohort-study
#16
Mario Testini, Alessandro Pasculli, Giovanna Di Meo, Valentina Ferraro, Francesco Logoluso, Francesco Minerva, Angela Pezzolla, Angela Gurrado
INTRODUCTION: When total thyroidectomy is performed for substernal goitre, a high risk of morbidity is reported. Advanced vessel sealing devices provide an alternative to the conventional clamp and tie technique. The aim of this study is to compare the outcome of patients who underwent total thyroidectomy for substernal goitre using Ligasure Small Jaw, Harmonic Focus, or conventional technique. METHODS: Between 2011 and 2014, from a population of 393 patients undergoing surgery for thyroid disease, 75 (49 females, 26 males, mean age: 57...
November 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27687851/a-randomized-controlled-multicenter-us-food-and-drug-administration-trial-of-the-safety-and-efficacy-of-the-minerva-endometrial-ablation-system-one-year-follow-up-results
#17
Philippe Laberge, Jose Garza-Leal, Claude Fortin, David Grainger, Delbert Alan Johns, Royce T Adkins, James Presthus, Cindy Basinski, Monte Swarup, Richard Gimpelson, Nicholas Leyland, John Thiel, Micah Harris, Pamela E Burnett, Gene F Ray
STUDY OBJECTIVE: To assess the safety and effectiveness of the Minerva Endometrial Ablation System for the treatment of heavy menstrual bleeding in premenopausal women. DESIGN: Multicenter, randomized, controlled, international study (Canadian Task Force classification I). SETTING: Thirteen academic and private medical centers. PATIENTS: Premenopausal women (n = 153) suffering from heavy menstrual bleeding (PALM-COEIN: E, O)...
January 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27683101/an-amphotericin-b-derivative-equally-potent-to-amphotericin-b-and-with-increased-safety
#18
Armando Antillón, Alexander H de Vries, Marcel Espinosa-Caballero, José Marcos Falcón-González, David Flores Romero, Javier González-Damián, Fabiola Eloísa Jiménez-Montejo, Angel León-Buitimea, Manuel López-Ortiz, Ricardo Magaña, Siewert J Marrink, Rosmarbel Morales-Nava, Xavier Periole, Jorge Reyes-Esparza, Josué Rodríguez Lozada, Tania Minerva Santiago-Angelino, María Cristina Vargas González, Ignacio Regla, Mauricio Carrillo-Tripp, Mario Fernández-Zertuche, Lourdes Rodríguez-Fragoso, Iván Ortega-Blake
Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely studied for this purpose and understanding it would contribute to the development of safe derivatives. Our study examined polyene action, including chemical synthesis, electrophysiology, pharmacology, toxicology and molecular dynamics...
2016: PloS One
https://www.readbyqxmd.com/read/27668901/hepatitis-c-and-immigration-a-multicentre-study
#19
Gaetano Scotto, Orlando Armignacco, Giulio Starnini, Ruggiero Francavilla, Giuseppe Foti, Vincenzo Portelli, Maurizio Mazzeo, Nicola Minerva, Vito Carretta, Lorenzo Lo Muzio, Vincenzina Fazio
This retrospective multicentre study aims to evaluate the clinical and epidemiological features of HCV infection in a cohort of immigrants in Italy. Tests were carried out on 194 HCV positive subjects, who represented 5.7% of the participants at baseline screening: the virological (viral load, genotype) and biochemical appearance of their infection was determined, and the disease was staged by histological examination in the patients who had indicated their willingness. Standard therapy (peg-interferon + ribavirin) was implemented in patients who agreed to undergo treatment...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27661679/evidence-for-neutral-current-diffractive-%C3%AF-0-production-from-hydrogen-in-neutrino-interactions-on-hydrocarbon
#20
J Wolcott, L Aliaga, O Altinok, A Bercellie, M Betancourt, A Bodek, A Bravar, H Budd, T Cai, M F Carneiro, J Chvojka, H da Motta, J Devan, S A Dytman, G A Díaz, B Eberly, E Endress, J Felix, L Fields, R Fine, R Galindo, H Gallagher, T Golan, R Gran, D A Harris, A Higuera, K Hurtado, M Kiveni, J Kleykamp, M Kordosky, T Le, E Maher, S Manly, W A Mann, C M Marshall, D A Martinez Caicedo, K S McFarland, C L McGivern, A M McGowan, B Messerly, J Miller, A Mislivec, J G Morfín, J Mousseau, D Naples, J K Nelson, A Norrick, Nuruzzaman, J Osta, V Paolone, J Park, C E Patrick, G N Perdue, L Rakotondravohitra, M A Ramirez, H Ray, L Ren, D Rimal, P A Rodrigues, D Ruterbories, H Schellman, D W Schmitz, C J Solano Salinas, S Sánchez Falero, N Tagg, B G Tice, E Valencia, T Walton, M Wospakrik, D Zhang
The MINERvA experiment observes an excess of events containing electromagnetic showers relative to the expectation from Monte Carlo simulations in neutral-current neutrino interactions with mean beam energy of 4.5 GeV on a hydrocarbon target. The excess is characterized and found to be consistent with neutral-current π^{0} production with a broad energy distribution peaking at 7 GeV and a total cross section of 0.26±0.02(stat.)±0.08(sys.)×10^{-39}  cm^{2}. The angular distribution, electromagnetic shower energy, and spatial distribution of the energy depositions of the excess are consistent with expectations from neutrino neutral-current diffractive π^{0} production from hydrogen in the hydrocarbon target...
September 9, 2016: Physical Review Letters
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