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https://www.readbyqxmd.com/read/27857867/dna-methylation-signature-of-post-injury-neointimal-cells-during-vascular-remodeling-in-the-rat-balloon-injury-model
#1
Jendai Richards, Henry Ato Ogoe, Wenzhi Li, Oguljahan Babayewa, Wei Xu, Tameka Bythwood, Minerva Garcia-Barrios, Li Ma, Qing Song
Vascular smooth muscle cell (VSMC) accumulation in the neointimal is a common feature in vascular diseases such as atherosclerosis, transplant arteriosclerosis and restenosis. In this study, we isolated the neointimal cells and uninjured residential vascular smooth muscle cells by laser micro dissection and carried out single-cell whole-genome methylation sequencing. We also sequenced the bisulfite converted genome of circulating bone-marrow-derived cells such as peripheral blood mononuclear cells (PBMC) and bone marrow mononuclear cells (BMMC)...
July 2016: Molecular Biology (Los Angeles, Calif.)
https://www.readbyqxmd.com/read/27792697/-cutaneous-manifestations-in-inflammatory-bowel-disease
#2
Sonia Chavez-Álvarez, Minerva Gómez-Flores, Jorge Ocampo-Candiani
Inflammatory bowel disease (IBD), mainly chronic unspecific ulcerative colitis and Crohn's disease have increased in incidence in the last decades. These have multiple extraintestinal manifestations, with those of the skin appearing after the intestinal clinical presentation. These are classified as: granulomatous dermatosis, reactive dermatosis, and those secondary to treatment of IBD, and other dermatosis. This article presents the pathogenesis, clinical approach, treatment and expected evolution of these manifestations...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27760390/ms-imaging-and-mass-spectrometric-synaptosome-profiling-identify-pep-19-pcp4-as-a-synaptic-molecule-involved-in-spatial-learning-in-mice
#3
Jeroen Aerts, Annelies Laeremans, Laurens Minerva, Kurt Boonen, Budamgunta Harshavardhan, Rudi D'hooge, Dirk Valkenborg, Geert Baggerman, Lutgarde Arckens
The Morris water maze (MWM) spatial learning task has been demonstrated to involve a cognitive switch of action control to serve the transition from an early towards a late learning phase. However, the molecular mechanisms governing this switch are largely unknown. We employed MALDI MS imaging (MSI) to screen for changes in expression of small proteins in brain structures implicated in the different learning phases. We compared mice trained for 3days and 30days in the MWM, reflecting an early and a late learning phase in relation to the acquisition of a spatial learning task...
October 17, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27727239/human-whole-genome-genotype-and-transcriptome-data-for-alzheimer-s-and-other-neurodegenerative-diseases
#4
Mariet Allen, Minerva M Carrasquillo, Cory Funk, Benjamin D Heavner, Fanggeng Zou, Curtis S Younkin, Jeremy D Burgess, High-Seng Chai, Julia Crook, James A Eddy, Hongdong Li, Ben Logsdon, Mette A Peters, Kristen K Dang, Xue Wang, Daniel Serie, Chen Wang, Thuy Nguyen, Sarah Lincoln, Kimberly Malphrus, Gina Bisceglio, Ma Li, Todd E Golde, Lara M Mangravite, Yan Asmann, Nathan D Price, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner
Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human disease variants are enriched for polymorphisms that affect gene expression, including some that are known to associate with expression changes in the brain. Postulating that many variants confer risk to neurodegenerative disease via transcriptional regulatory mechanisms, we have analyzed gene expression levels in the brain tissue of subjects with AD and related diseases...
October 11, 2016: Scientific Data
https://www.readbyqxmd.com/read/27717058/pro-life-arguments-against-infanticide-and-why-they-are-not-convincing
#5
Joona Räsänen
Alberto Giubilini and Francesca Minerva's controversial article 'After-Birth Abortion: Why Should the Baby Live?' has received a lot of criticism since its publishing. Part of the recent criticism has been made by pro-life philosopher Christopher Kaczor, who argues against infanticide in his updated book 'Ethics of Abortion'. Kaczor makes four arguments to show where Giubilini and Minerva's argument for permitting infanticide goes wrong. In this article I argue that Kaczor's arguments, and some similar arguments presented by other philosophers, are mistaken and cannot show Giubilini and Minerva's view to be flawed...
November 2016: Bioethics
https://www.readbyqxmd.com/read/27708749/permanent-draft-genome-of-thermithiobaclillus-tepidarius-dsm-3134-t-a-moderately-thermophilic-obligately-chemolithoautotrophic-member-of-the-acidithiobacillia
#6
Rich Boden, Lee P Hutt, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, Tatiparthi Reddy, Chew Yee Ngan, Chris Daum, Nicole Shapiro, Victor Markowitz, Natalia Ivanova, Tanja Woyke, Nikos Kyrpides
Thermithiobacillus tepidarius DSM 3134(T) was originally isolated (1983) from the waters of a sulfidic spring entering the Roman Baths (Temple of Sulis-Minerva) at Bath, United Kingdom and is an obligate chemolithoautotroph growing at the expense of reduced sulfur species. This strain has a genome size of 2,958,498 bp. Here we report the genome sequence, annotation and characteristics. The genome comprises 2,902 protein coding and 66 RNA coding genes. Genes responsible for the transaldolase variant of the Calvin-Benson-Bassham cycle were identified along with a biosynthetic horseshoe in lieu of Krebs' cycle sensu stricto...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27703782/ketamine-stimulating-antidepressant-treatment
#7
Gin S Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A Frye, Michael Gitlin, Sidney H Kennedy, Terence A Ketter, Raymond W Lam, Rupert McShane, Alex J Mitchell, Michael J Ostacher, Sakina J Rizvi, Michael E Thase, Mauricio Tohen
SUMMARY: The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27696716/in-vitro-evaluation-of-apoptotic-effect-of-bis-acetylacetonato-k-2-o-o-1-10-phenanthroline-k-2-n-n-zn-ii-complex
#8
Cristina Trejo-Solis, Mayra A Alvarez-Lemus, Dolores Jiménez-Farfán, Isabel Anaya-Rubio, Rosendo López-González, Guadalupe Palencia, Dora M Frías-Márquez, Gerardo González-García, Carmen Rubio-Osornio, Minerva Calvillo-Velasco, Guadalupe Márquez-Chablé
Phenanthroline derivatives have been reported as potential bioactive compounds because of their ability to interact with DNA. In order to evaluate the antiproliferative effect of bis(acetylacetonate-k(2) O,O)(1,10-phenanthroline-k(2) N,N)Zn(II) or Zn(acac)2 (phen) complex, the compound was obtained in a simple manner and further characterized to determine crystal structure, thermal behavior, morphology and spectroscopic properties. The structure of the complex was confirmed by X-Ray single structure as well as by solution solid-state (13) C CP/MAS NMR...
October 2, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27693824/advanced-vessel-sealing-devices-in-total-thyroidectomy-for-substernal-goitre-a-retrospective-cohort-study
#9
Mario Testini, Alessandro Pasculli, Giovanna Di Meo, Valentina Ferraro, Francesco Logoluso, Francesco Minerva, Angela Pezzolla, Angela Gurrado
INTRODUCTION: When total thyroidectomy is performed for substernal goitre, a high risk of morbidity is reported. Advanced vessel sealing devices provide an alternative to the conventional clamp and tie technique. The aim of this study is to compare the outcome of patients who underwent total thyroidectomy for substernal goitre using Ligasure Small Jaw, Harmonic Focus, or conventional technique. METHODS: Between 2011 and 2014, from a population of 393 patients undergoing surgery for thyroid disease, 75 (49 females, 26 males, mean age: 57...
September 28, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27687851/a-randomized-controlled-multi-center-fda-trial-of-the-safety-and-efficacy-of-the-minerva-endometrial-ablation-system-one-year-follow-up-results
#10
Philippe Laberge, Jose Garza-Leal, Claude Fortin, David Grainger, Delbert Alan Johns, Royce T Adkins, James Presthus, Cindy Basinski, Monte Swarup, Richard Gimpelson, Nicholas Leyland, John Thiel, Micah Harris, Pamela E Burnett, Gene F Ray
STUDY OBJECTIVE: To assess the safety and effectiveness of the Minerva Endometrial Ablation System for the treatment of heavy menstrual bleeding in pre-menopausal women. DESIGN: Multi-center, randomized, controlled, international study. Canadian Task Force Classification I. SETTING: 13 academic and private medical centers. PATIENTS: 153 pre-menopausal women suffering from Heavy Menstrual Bleeding (PALM-COEIN: E,O). INTERVENTION: Patients were treated using the Minerva Endometrial Ablation System or rollerball ablation...
September 26, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27683101/an-amphotericin-b-derivative-equally-potent-to-amphotericin-b-and-with-increased-safety
#11
Armando Antillón, Alexander H de Vries, Marcel Espinosa-Caballero, José Marcos Falcón-González, David Flores Romero, Javier González-Damián, Fabiola Eloísa Jiménez-Montejo, Angel León-Buitimea, Manuel López-Ortiz, Ricardo Magaña, Siewert J Marrink, Rosmarbel Morales-Nava, Xavier Periole, Jorge Reyes-Esparza, Josué Rodríguez Lozada, Tania Minerva Santiago-Angelino, María Cristina Vargas González, Ignacio Regla, Mauricio Carrillo-Tripp, Mario Fernández-Zertuche, Lourdes Rodríguez-Fragoso, Iván Ortega-Blake
Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely studied for this purpose and understanding it would contribute to the development of safe derivatives. Our study examined polyene action, including chemical synthesis, electrophysiology, pharmacology, toxicology and molecular dynamics...
2016: PloS One
https://www.readbyqxmd.com/read/27668901/hepatitis-c-and-immigration-a-multicentre-study
#12
Gaetano Scotto, Orlando Armignacco, Giulio Starnini, Ruggiero Francavilla, Giuseppe Foti, Vincenzo Portelli, Maurizio Mazzeo, Nicola Minerva, Vito Carretta, Lorenzo Lo Muzio, Vincenzina Fazio
This retrospective multicentre study aims to evaluate the clinical and epidemiological features of HCV infection in a cohort of immigrants in Italy. Tests were carried out on 194 HCV positive subjects, who represented 5.7% of the participants at baseline screening: the virological (viral load, genotype) and biochemical appearance of their infection was determined, and the disease was staged by histological examination in the patients who had indicated their willingness. Standard therapy (peg-interferon + ribavirin) was implemented in patients who agreed to undergo treatment...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27661679/evidence-for-neutral-current-diffractive-%C3%AF-0-production-from-hydrogen-in-neutrino-interactions-on-hydrocarbon
#13
J Wolcott, L Aliaga, O Altinok, A Bercellie, M Betancourt, A Bodek, A Bravar, H Budd, T Cai, M F Carneiro, J Chvojka, H da Motta, J Devan, S A Dytman, G A Díaz, B Eberly, E Endress, J Felix, L Fields, R Fine, R Galindo, H Gallagher, T Golan, R Gran, D A Harris, A Higuera, K Hurtado, M Kiveni, J Kleykamp, M Kordosky, T Le, E Maher, S Manly, W A Mann, C M Marshall, D A Martinez Caicedo, K S McFarland, C L McGivern, A M McGowan, B Messerly, J Miller, A Mislivec, J G Morfín, J Mousseau, D Naples, J K Nelson, A Norrick, Nuruzzaman, J Osta, V Paolone, J Park, C E Patrick, G N Perdue, L Rakotondravohitra, M A Ramirez, H Ray, L Ren, D Rimal, P A Rodrigues, D Ruterbories, H Schellman, D W Schmitz, C J Solano Salinas, S Sánchez Falero, N Tagg, B G Tice, E Valencia, T Walton, M Wospakrik, D Zhang
The MINERvA experiment observes an excess of events containing electromagnetic showers relative to the expectation from Monte Carlo simulations in neutral-current neutrino interactions with mean beam energy of 4.5 GeV on a hydrocarbon target. The excess is characterized and found to be consistent with neutral-current π^{0} production with a broad energy distribution peaking at 7 GeV and a total cross section of 0.26±0.02(stat.)±0.08(sys.)×10^{-39}  cm^{2}. The angular distribution, electromagnetic shower energy, and spatial distribution of the energy depositions of the excess are consistent with expectations from neutrino neutral-current diffractive π^{0} production from hydrogen in the hydrocarbon target...
September 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27620329/recombinant-trichomonas-vaginalis-eif-5a-protein-expressed-from-a-eukaryotic-system-binds-specifically-to-mammalian-and-putative-trichomonal-eif-5a-response-elements-eres
#14
Bertha Isabel Carvajal-Gamez, Laura Vázquez Carrillo, Julio César Torres-Romero, Minerva Camacho-Nuez, María Dolores Ponce-Regalado, César López Camarillo, María Elizbeth Alvarez-Sánchez
Trichomonas vaginalis eIF-5A-like protein (TveIF-5A) belongs to the highly conserved eIF-5A family of proteins that contains a unique polyamine-derived amino acid, hypusine. Recently, we determined that the polyamine putrescine is required for tveif-5a mRNA stability, and it is necessary for stability and maturation of the TveIF-5A protein. Eukaryotic eIF-5A is known to be involved in mRNA turnover and is capable of sequence-specific RNA binding to eIF-5A response elements (EREs). These ERE sequences are present in diverse mammalian mRNAs, including human cyclooxygenase-2 (cox-2)...
December 2016: Parasitology International
https://www.readbyqxmd.com/read/27541459/evidence-of-coherent-k-meson-production-in-neutrino-nucleus-scattering
#15
Z Wang, C M Marshall, L Aliaga, O Altinok, L Bellantoni, A Bercellie, M Betancourt, A Bodek, A Bravar, H Budd, T Cai, M F Carneiro, H da Motta, S A Dytman, G A Díaz, B Eberly, E Endress, J Felix, L Fields, R Fine, R Galindo, H Gallagher, A Ghosh, T Golan, R Gran, D A Harris, A Higuera, K Hurtado, M Kiveni, J Kleykamp, M Kordosky, T Le, E Maher, S Manly, W A Mann, D A Martinez Caicedo, K S McFarland, C L McGivern, A M McGowan, B Messerly, J Miller, A Mislivec, J G Morfín, J Mousseau, D Naples, J K Nelson, A Norrick, Nuruzzaman, V Paolone, J Park, C E Patrick, G N Perdue, L Rakotondravohitra, M A Ramirez, R D Ransome, H Ray, L Ren, D Rimal, P A Rodrigues, D Ruterbories, H Schellman, D W Schmitz, C Simon, C J Solano Salinas, B G Tice, E Valencia, T Walton, J Wolcott, M Wospakrik, G Zavala, D Zhang
Neutrino-induced charged-current coherent kaon production ν_{μ}A→μ^{-}K^{+}A is a rare, inelastic electroweak process that brings a K^{+} on shell and leaves the target nucleus intact in its ground state. This process is significantly lower in rate than the neutrino-induced charged-current coherent pion production because of Cabibbo suppression and a kinematic suppression due to the larger kaon mass. We search for such events in the scintillator tracker of MINERvA by observing the final state K^{+}, μ^{-}, and no other detector activity, and by using the kinematics of the final state particles to reconstruct the small momentum transfer to the nucleus, which is a model-independent characteristic of coherent scattering...
August 5, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27540174/design-synthesis-and-testing-toward-a-57-codon-genome
#16
Nili Ostrov, Matthieu Landon, Marc Guell, Gleb Kuznetsov, Jun Teramoto, Natalie Cervantes, Minerva Zhou, Kerry Singh, Michael G Napolitano, Mark Moosburner, Ellen Shrock, Benjamin W Pruitt, Nicholas Conway, Daniel B Goodman, Cameron L Gardner, Gary Tyree, Alexandra Gonzales, Barry L Wanner, Julie E Norville, Marc J Lajoie, George M Church
Recoding--the repurposing of genetic codons--is a powerful strategy for enhancing genomes with functions not commonly found in nature. Here, we report computational design, synthesis, and progress toward assembly of a 3.97-megabase, 57-codon Escherichia coli genome in which all 62,214 instances of seven codons were replaced with synonymous alternatives across all protein-coding genes. We have validated 63% of recoded genes by individually testing 55 segments of 50 kilobases each. We observed that 91% of tested essential genes retained functionality with limited fitness effect...
August 19, 2016: Science
https://www.readbyqxmd.com/read/27538543/skull-traction-for-cervical-spinal-injury-in-enugu-a-5-year-retrospective-multicenter-analysis-of-the-clinical-outcomes-of-patients-treated-with-two-common-devices
#17
E O Uche, O E Nwankwo, E Okorie, A Muobike
BACKGROUND: Treatment of cervical spine injury is the most challenging of all the injuries of the spine, and there is yet no agreement on the best method of care. OBJECTIVE: We studied the complications and outcome of two skull traction devices used to treat cases of cervical spine injury in three centers in Enugu, South East Nigeria. PATIENTS AND METHODS: A retrospective analysis of patients with cervical spine injury managed with skull traction as the definitive treatment using either Crutchfield or Gardner-Wells tongs over a 5-year period (April 2008-March 2013)...
September 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27493663/does-frailty-predict-health-care-utilization-in-community-living-older-romanians
#18
Marinela Olaroiu, Minerva Ghinescu, Viorica Naumov, Ileana Brinza, Wim van den Heuvel
Background. The predictive value of frailty assessment is still debated. We analyzed the predictive value of frailty of independent living elderly. The outcomes variables were visits to the general practitioner, hospital admission, and occurrence of new health problems. Methods. A one-year follow-up study was executed among 215 community-living old Romanians. General practitioners reported the outcome variables of patients, whose frailty was assessed one year before, using the Groningen Frailty Indicator. The predictive validity is analyzed by descriptive and regression analysis...
2016: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/27441714/integration-and-visualization-of-translational-medicine-data-for-better-understanding-of-human-diseases
#19
Venkata Satagopam, Wei Gu, Serge Eifes, Piotr Gawron, Marek Ostaszewski, Stephan Gebel, Adriano Barbosa-Silva, Rudi Balling, Reinhard Schneider
Translational medicine is a domain turning results of basic life science research into new tools and methods in a clinical environment, for example, as new diagnostics or therapies. Nowadays, the process of translation is supported by large amounts of heterogeneous data ranging from medical data to a whole range of -omics data. It is not only a great opportunity but also a great challenge, as translational medicine big data is difficult to integrate and analyze, and requires the involvement of biomedical experts for the data processing...
June 2016: Big Data
https://www.readbyqxmd.com/read/27434767/corrigendum-a-phgdh-inhibitor-reveals-coordination-of-serine-synthesis-and-one-carbon-unit-fate
#20
Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, Jason M Rohde, Caroline A Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W Chen, Lucas B Sullivan, Brian P Fiske, Steve Cho, Elizaveta Freinkman, Kıvanç Birsoy, Monther-Remaileh Abu, Yoav D Shaul, Chieh Min Liu, Minerva Zhou, Min Jung Koh, Haeyoon Chung, Shawn M Davidson, Alba Luengo, Amy Q Wang, Xin Xu, Adam Yasgar, Li Liu, Ganesha Rai, Kenneth D Westover, Matthew G Vander Heiden, Min Shen, Nathanael S Gray, Matthew B Boxer, David M Sabatini
No abstract text is available yet for this article.
July 19, 2016: Nature Chemical Biology
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