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craniofacial cleft

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https://www.readbyqxmd.com/read/29142654/correlation-between-nasoalveolar-molding-and-surgical-aesthetic-functional-and-socioeconomic-outcomes-following-primary-repair-surgery-a-systematic-review
#1
REVIEW
Sophie Maillard, Jean-Marc Retrouvey, Mairaj K Ahmed, Peter J Taub
Objectives: The authors performed a systematic review to evaluate the potential beneficial effects of the nasoalveolar molding appliance on nonsyndromic unilateral clefts of the lip and/or palate prior to primary lip repair. Material and Methods: A literature search was performed using three electronic databases (PubMed, Embase, Web of Science) and three journals ("Cleft Palate-Craniofacial Journal", "Plastic and Reconstructive Surgery Journal" and "American Journal of Orthodontics and Dentofacial Orthopaedic") from January 1980 to April 2017...
July 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/29135729/strengthening-evidence-in-cleft-and-craniofacial-surgery
#2
Jordan W Swanson, Marco A Swanson
No abstract text is available yet for this article.
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29109837/comparing-plastic-surgery-and-otolaryngology-management-in-cleft-care-an-analysis-of-4-999-cases
#3
Kevin T Jubbal, Dmitry Zavlin, Shola Olorunnipa, Anthony Echo, Edward P Buchanan, Larry H Hollier
Care for patients with cleft lip and palate is best managed by a craniofacial team consisting of a variety of specialists, including surgeons, who are generally plastic surgeons or otolaryngologists trained in the United States. The goal of this study was to compare the surgical approaches and management algorithms of cleft lip, cleft palate, and nasal reconstruction between plastic surgeons and otolaryngologists. We performed a retrospective analysis of the American College of Surgeons' National Surgical Quality Improvement Program Pediatric database between 2012 and 2014 to identify patients undergoing primary repair of cleft lip, cleft palate, and associated rhinoplasty...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29104030/orthognathic-surgical-outcomes-in-patients-with-and-without-craniofacial-anomalies
#4
Zohra Metalwala, Christopher Okunseri, Steven Fletcher, Veerasathpurush Allareddy
PURPOSE: The objective of this study is to examine hospitalization outcomes after orthognathic surgery. This study tests the hypothesis that patients with craniofacial anomalies have higher billed hospital charges, longer lengths of stay, and increased odds of development of infectious complications when compared with patients without craniofacial anomalies. MATERIALS AND METHODS: The Nationwide Inpatient Sample for the years 2012 and 2013 was used. All patients who underwent an orthognathic surgical procedure were selected...
October 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29084117/a-review-of-randomized-controlled-trials-in-cleft-and-craniofacial-surgery
#5
Jonathan M Bekisz, Elise Fryml, Roberto L Flores
This study presents a systematic review of randomized controlled trials (RCTs) in cleft and craniofacial surgery. All studies reporting on RCTs in cleft and craniofacial surgery were identified on PubMed using the search terms "cleft," "velopharyngeal insufficiency," "velopharyngeal dysfunction," "nasoalveolar molding," "gingivoperiosteoplasty," "Pierre Robin sequence," "craniofacial," "craniosynostosis," "craniofacial microsomia," "hemifacial microsomia," "hypertelorism," "Le Fort," "monobloc," "distraction osteogenesis," "Treacher Collins," and "Goldenhar...
October 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29077685/oxygen-left-right-asymmetry-and-cleft-lip-and-palate
#6
Alexandre R Vieira, Sheila Dattilo
Cleft lip and palate is the most common craniofacial birth defect, and its etiology has been the focus of many reports in the literature. It is well accepted that both genetics and environment play a role in the condition; however, the authors still have not been able to translate what have been learned into clinical applications. This paper provides an interpretation of 2 possible mechanisms leading to cleft lip and palate in humans. First, the authors reflect on the known association between maternal cigarette smoking and risk for cleft lip and palate and the proposed hypoxic mechanism put forward to explain this association...
October 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29065370/interferon-regulatory-factor-6-variants-affect-nasolabial-morphology-in-east-asian-populations
#7
Daisuke Tomita, Tetsutaro Yamaguchi, Takatoshi Nakawaki, Yu Hikita, Mohamed Adel, Yong-Il Kim, Shugo Haga, Masahiro Takahashi, Akira Kawaguchi, Mutsumi Isa, Soo-Byung Park, Hajime Ishida, Koutaro Maki, Ryosuke Kimura
OBJECTIVE: The interferon regulatory factor 6 gene (IRF6) is one of the most conspicuous genes among a large number of candidate risk genes for non-syndromic cleft lip with or without cleft palate, which is considered to be a multifactorial defect. Variants of IRF6 are also suggested to affect normal craniofacial variations, especially in the area of the nose and the upper lip. In the present study, we used lateral cephalograms to establish the relationship between IRF6 and sagittal nasolabial morphology in healthy East Asian subjects...
October 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29042924/inhibition-of-periderm-removal-in-all-trans-retinoic-acid-induced-cleft-palate-in-mice
#8
Ya-Dong Zhang, Shi-Yi Dong, Hong-Zhang Huang
Cleft palate is a common craniofacial birth defect. The aim of the present study was to investigate the effect of excess all-trans retinoic acid (atRA) on periderm removal and the disappearance of basal medial edge epithelial (MEE) cells during palatogenesis, particularly during the stage prior to contact. atRA (200 mg/kg) was administered to C57BL/6N mice at embryonic day (E) 12.0 by gavage. Fetal palates were processed and analyzed by histology and electron microscopy. Single palate shelf peridermal cells were removed and cultured in the presence of atRA (3 µM) only or in the presence of or the caspase inhibitor, Z-VAD (100 µM) only, for 48 h...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29023340/associations-between-disinfection-by-product-exposures-and-craniofacial-birth-defects
#9
John A Kaufman, J Michael Wright, Amanda Evans, Zorimar Rivera-Núñez, Amy Meyer, Michael G Narotsky
OBJECTIVE: Examine associations between craniofacial birth defects (CFDs) and disinfection by-product (DBP) exposures, including the sum of four trihalomethanes (THM4) and five haloacetic acids (HAA5) (i.e., DBP9). METHODS: We calculated first trimester adjusted odds ratios (aORs) for different DBPs in a matched case-control study of 366 CFD cases in Massachusetts towns with complete 1999-2004 THM and HAA data. RESULTS: We detected elevated aORs for cleft palate with DBP9 (highest quintile aOR = 3...
October 11, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28980856/cryogel-scaffolds-from-patient-specific-3d-printed-molds-for-personalized-tissue-engineered-bone-regeneration-in-pediatric-cleft-craniofacial-defects
#10
Katherine R Hixon, Alexa M Melvin, Alexander Y Lin, Andrew F Hall, Scott A Sell
Bone defects are extremely common in children with cleft-craniofacial conditions, especially those with alveolar cleft defects and cranial defects. This study used patient-specific 3D-printed molds derived from computed tomography and cryogel scaffold fabrication as a proof of concept for the creation of site-specific implants for bone reconstruction. Cryogel scaffolds are unique tissue-engineered constructs formed at sub-zero temperatures. When thawed, the resulting structure is macroporous, sponge-like, and mechanically durable...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28957438/e-cigarette-aerosol-exposure-can-cause-craniofacial-defects-in-xenopus-laevis-embryos-and-mammalian-neural-crest-cells
#11
Allyson E Kennedy, Suraj Kandalam, Rene Olivares-Navarrete, Amanda J G Dickinson
Since electronic cigarette (ECIG) introduction to American markets in 2007, vaping has surged in popularity. Many, including women of reproductive age, also believe that ECIG use is safer than traditional tobacco cigarettes and is not hazardous when pregnant. However, there are few studies investigating the effects of ECIG exposure on the developing embryo and nothing is known about potential effects on craniofacial development. Therefore, we have tested the effects of several aerosolized e-cigarette liquids (e-cigAM) in an in vivo craniofacial model, Xenopus laevis, as well as a mammalian neural crest cell line...
2017: PloS One
https://www.readbyqxmd.com/read/28954202/ciliopathy-protein-tmem107-plays-multiple-roles-in-craniofacial-development
#12
P Cela, M Hampl, N A Shylo, K J Christopher, M Kavkova, M Landova, T Zikmund, S D Weatherbee, J Kaiser, M Buchtova
A broad spectrum of human diseases called ciliopathies is caused by defective primary cilia morphology or signal transduction. The primary cilium is a solitary organelle that responds to mechanical and chemical stimuli from extracellular and intracellular environments. Transmembrane protein 107 (TMEM107) is localized in the primary cilium and is enriched at the transition zone where it acts to regulate protein content of the cilium. Mutations in TMEM107 were previously connected with oral-facial-digital syndrome, Meckel-Gruber syndrome, and Joubert syndrome exhibiting a range of ciliopathic defects...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28953731/impact-of-a-cleft-and-craniofacial-center-on-an-academic-health-system
#13
Navid Pourtaheri, Aaron Kearney, Derrick C Wan, Gregory Lakin
BACKGROUND: The contributions of all physician specialties and ancillary services involved in cleft and craniofacial center care must be evaluated to fairly assess the financial impact of a cleft and craniofacial center. The authors hypothesized that the cleft and craniofacial center generates profitable downstream productivity for the academic health system. METHODS: This was a retrospective cohort study of all patients who presented to a cleft and craniofacial center in the first quarter of 2011...
October 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28949457/cranflow-an-application-for-record-taking-and-management-through-the-brazilian-database-on-craniofacial-anomalies
#14
Roberta M Volpe-Aquino, Isabella L Monlleó, Elaine Lustosa-Mendes, Amanda F Mora, Agnes C Fett-Conte, Têmis M Félix, Ana C Xavier, Rita Tonocchi, Erlane M Ribeiro, Rui Pereira, Raquel T Boy da Silva, Adriana A de Rezende, Denise P Cavalcanti, Vera L Gil-da-Silva-Lopes
BACKGROUND: The World Health Organization has recognized the relevance of databases on craniofacial anomalies since . To date, there is no universal standard instrument/database focused on risk factors, clinical and genetic data collection, and follow-up that enables comparison between different populations and genotype-phenotype correlation. Although studies have shown that specific genes would impact outcomes, knowledge is not sufficient to subsidize cost-effectiveness strategies for diagnosis, surgical decision, and a multi-professional approach toward personalized medicine...
September 26, 2017: Birth defects research
https://www.readbyqxmd.com/read/28947808/airway-changes-after-cleft-orthognathic-surgery-evaluated-by-three-dimensional-computed-tomography-and-overnight-polysomnographic-study
#15
Chun-Shin Chang, Christopher Glenn Wallace, Yen-Chang Hsiao, Yuh-Jia Hsieh, Yi-Chin Wang, Ning-Hung Chen, Yu-Fang Liao, Eric Jen-Wein Liou, Philip Kuo-Ting Chen, Jyh-Ping Chen, Yu-Ray Chen
Cleft lip and palate is the most common congenital craniofacial anomaly. Up to 60% of these patients will benefit from cleft orthognathic surgery, which consists primarily of maxillary advancement and mandibular setback to address midface retrusion and relative mandibular protrusion, respectively. It is believed that maxillary advancement can enlarge the airway whilst mandibular setback can reduce the airway, but this has not previously been quantified for cleft patients undergoing orthognathic surgery. This unique longitudinal prospective study of 18 patients was conducted between April 2013 and July 2016...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28944239/analysis-of-sequence-data-to-identify-potential-risk-variants-for-oral-clefts-in-multiplex-families
#16
Emily R Holzinger, Qing Li, Margaret M Parker, Jacqueline B Hetmanski, Mary L Marazita, Elisabeth Mangold, Kerstin U Ludwig, Margaret A Taub, Ferdouse Begum, Jeffrey C Murray, Hasan Albacha-Hejazi, Khalid Alqosayer, Giath Al-Souki, Abdullatiff Albasha Hejazi, Alan F Scott, Terri H Beaty, Joan E Bailey-Wilson
BACKGROUND: Nonsyndromic oral clefts are craniofacial malformations, which include cleft lip with or without cleft palate. The etiology for oral clefts is complex with both genetic and environmental factors contributing to risk. Previous genome-wide association (GWAS) studies have identified multiple loci with small effects; however, many causal variants remain elusive. METHODS: In this study, we address this by specifically looking for rare, potentially damaging variants in family-based data...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28927774/chronic-intestinal-pseudo-obstruction-in-a-child-with-treacher-collins-syndrome
#17
E Giabicani, J Lemale, L Dainese, S Boudjemaa, A Coulomb, P Tounian, B Dubern
BACKGROUND: Treacher Collins syndrome (TCS) mainly presents with severe craniofacial developmental abnormalities characterized by a combination of bilateral downward-slanting palpebral fissures, colobomas of the lower eyelids, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. It is due to mutations in Treacher Collins syndrome 1 (TCOF1) (5q32-q33.1) and Polymerase RNA 1 polypeptides D and C (POLR1D [13q12...
September 15, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28926086/common-variants-in-dlg1-locus-are-associated-with-non-syndromic-cleft-lip-with-or-without-cleft-palate
#18
Adrianna Mostowska, Agnieszka Gaczkowska, Kacper Żukowski, Kerstin U Ludwig, Kamil K Hozyasz, Piotr Wójcicki, Elizabeth Mangold, Anne C Böhmer, Stefanie Heilmann-Heimbach, Michael Knapp, Małgorzata Zadurska, Barbara Biedziak, Margareta Budner, Agnieszka Lasota, Agata Daktera-Micker, Paweł P Jagodziński
Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common craniofacial anomaly with a complex and heterogeneous etiology. Knowledge regarding specific genetic factors underlying this birth defect is still not well understood. Therefore, we conducted an independent replication analysis for the top-associated variants located within the DLG1 locus at chromosome 3q29, which was identified as a novel cleft-susceptibility locus in our genome-wide association study (GWAS). Mega-analysis of the pooled individual data from the GWAS and replication study confirmed that common DLG1 variants are associated with the risk of nsCL/P...
September 19, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28913309/2017-spring-update-a-letter-from-the-president-of-the-korean-cleft-palate-craniofacial-association
#19
Chullhoon Chung
No abstract text is available yet for this article.
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28906329/cleft-lip-and-palate-repair-our-experience
#20
Gian Luca Gatti, Nicola Freda, Alessandro Giacomina, Marina Montemagni, Andrea Sisti
INTRODUCTION: Cleft lip and palate is the most frequent congenital craniofacial deformity. In this article, the authors describe their experience with cleft lip and palate repair. METHODS: Data regarding patients presenting with primary diagnosis of cleft lip and/or palate, between 2009 and 2015, were reviewed. Details including demographics, type of cleft, presence of known risk factors, surgical details, and follow-up visits were collected. Documented complications were reported...
September 12, 2017: Journal of Craniofacial Surgery
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