keyword
MENU ▼
Read by QxMD icon Read
search

miRNA expression profiling

keyword
https://www.readbyqxmd.com/read/29036922/microrna-and-mrna-dysregulation-in-astrocytes-infected-with-zika-virus
#1
Robert A Kozak, Anna Majer, Mia J Biondi, Sarah J Medina, Lee W Goneau, Babu V Sajesh, Jessy A Slota, Vanessa Zubach, Alberto Severini, David Safronetz, Shannon L Hiebert, Daniel R Beniac, Timothy F Booth, Stephanie A Booth, Gary P Kobinger
The Zika virus (ZIKV) epidemic is an ongoing public health concern. ZIKV is a flavivirus reported to be associated with microcephaly, and recent work in animal models demonstrates the ability of the virus to cross the placenta and affect fetal brain development. Recent findings suggest that the virus preferentially infects neural stem cells and thereby deregulates gene expression, cell cycle progression, and increases cell death. However, neuronal stem cells are not the only brain cells that are susceptible to ZIKV and infection of other brain cells may contribute to disease progression...
October 14, 2017: Viruses
https://www.readbyqxmd.com/read/29036818/a-9-microrna-signature-in-serum-serves-as-a-noninvasive-biomarker-in-early-diagnosis-of-alzheimer-s-disease
#2
Rui Guo, Gang Fan, Jian Zhang, Chunxiao Wu, Yifeng Du, Hui Ye, Zhang Li, Lili Wang, Zhihui Zhang, Lu Zhang, Yueran Zhao, Zhiming Lu
Alzheimer's disease (AD) is the most common type of age-related neurodegenerative disorder; nevertheless, nowadays there are no reliable biomarkers or non-invasive techniques available for its early detection. Recent studies have indicated that the circulating level profiles of microRNAs (miRNAs) have the potential to be used as valuable biomarkers for diagnosis, staging, and progress monitoring of various diseases. Here we report a novel 9-miRNA signature (hsa-miR-26a-5p, hsa-miR-181c-3p, hsa-miR-126-5p, hsa-miR-22-3p, hsa-miR-148b-5p, hsa-miR-106b-3p, hsa-miR-6119-5p, hsa-miR-1246, and hsa-miR-660-5p) that can be utilized as biomarker for detecting AD...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29034845/predicting-mirna-association-with-corresponding-target-genes-and-single-nucleotide-polymorphisms-in-altered-renal-pathophysiology
#3
Pradeep Jaswani, Swayam Prakash, Narayan Prasad, Suraksha Agrawal, Raj Kumar Sharma
BACKGROUND: Translational research on miRNAs develops reliable biomarkers for diagnosis and prognosis of renal diseases. Bioinformatic analyses and systems biology could drive the research for knowing new informative miRNA targets. OBJECTIVES: This study proposes an approach to identify miRNA specific significant target genes, and single nucleotide polymorphisms (SNPs) associated with renal pathophysiology. METHODS: miRNAs were selected after removing duplicity, on the basis of techniques used, and disease spectrum width score...
October 16, 2017: MicroRNA
https://www.readbyqxmd.com/read/29034844/microrna-cancer-and-diet-facts-and-new-exciting-perspectives
#4
Maria Letizia Motti, Stefania D'Angelo, Rosaria Meccariello
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs able to regulate gene expression at multiple levels. They are detected in tissues, blood, and other body fluids with high stability and have a recognized role in the maintaining of tissue homeostasis. Aberrant expression profile of miRNAs has been observed in several diseases, primarily cancer. As a consequence, the analysis of miRNA signature has recognized diagnostic and prognostic role in human diseases, and the development of miRNA-based therapies is currently under investigation...
October 13, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29032608/microrna-profiling-reveals-dysregulated-micrornas-and-their-target-gene-regulatory-networks-in-cemento-ossifying-fibroma
#5
Thaís Dos Santos Fontes Pereira, João Artur Ricieri Brito, André Luiz Sena Guimarães, Carolina Cavaliéri Gomes, Júlio Cesar Tanos de Lacerda, Wagner Henriques de Castro, Roney Santos Coimbra, Marina Gonçalves Diniz, Ricardo Santiago Gomez
BACKGROUND: Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis and its treatment results morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis...
October 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29031772/identification-and-comparative-profiling-of-ovarian-and-testicular-micrornas-in-the-swimming-crab-portunus-trituberculatus
#6
Xianliang Meng, Xiaohui Zhang, Jian Li, Ping Liu
MicroRNAs (miRNAs) are a class of endogenous non-coding small RNA, known as key post-transcriptional regulators for development and function of reproductive organ in animals. However, limited information is currently available on the regulatory roles of miRNAs in crustacean reproduction. In the present study, we performed small RNA deep sequencing in ovary and testis tissues of the swimming crab Portunus trituberculatus, which is a commercially important species in East Asian countries, to identify and characterize the miRNAs in gonads...
October 11, 2017: Gene
https://www.readbyqxmd.com/read/29029543/the-mir-200-family-in-ovarian-cancer
#7
REVIEW
Maria Koutsaki, Massimo Libra, Demetrios A Spandidos, Apostolos Zaravinos
Ovarian cancer (OC) is the most lethal gynecological malignancy. Its insidious nature, manifesting with little to no symptoms until the disease progresses to metastasis, along with a wide diversity of histological subtypes and corresponding clinical behavior, poses significant therapeutic challenges. The genetic profiling of this aggressive tumor and its subtypes has led to the identification of various molecular markers of prognosis. Among these, the miR-200 family of miRNAs appears to play an important role...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028927/tumor-origin-detection-with-tissue-specific-mirna-and-dna-methylation-markers
#8
Wei Tang, Shixiang Wan, Zhen Yang, Andrew E Teschendorff, Quan Zou
Motivation: A clear identification of the primary site of tumor is of great importance to the next targeted site-specific treatments and could efficiently improve patient's overall survival. Even though many classifiers based on gene expression had been proposed to predict the tumor primary, only a few studies focus on using DNA methylation profiles to develop classifiers, and none of them compares the performance of classifiers based on different profiles. Results: We introduced novel selection strategies to identify highly tissue-specific CpG sites and then used the random forest approach to construct the classifiers to predict the origin of tumors...
September 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29027986/effects-of-conjugated-linoleic-acid-supplementation-on-the-expression-profile-of-mirnas-in-porcine-adipose-tissue
#9
Qi Wang, Renli Qi, Hong Liu, Jing Wang, Wenming Huang, Feiyun Yang, Jinxiu Huang
Conjugated linoleic acids (CLAs) play a major role in adipocyte differentiation and lipid metabolism in animals. MicroRNAs (miRNAs) appear to be involved in many biological processes in adipose tissue. However, the specific influence on miRNAs by CLA supplementation in porcine adipose tissue remains unclear. Thus, we continuously added 1.5% CLA to the pig diet from the embryo stage to the finishing period and conducted a high-throughput sequencing approach to analyse the changes in adipose tissue miRNAs. We identified 283 known porcine miRNAs, and 14 miRNAs were differentially expressed in response to CLA treatment...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29026152/genetic-and-epigenetic-profiling-reveals-ezh2-mediated-down-regulation-of-oct-4-involves-nr2f2-during-cardiac-differentiation-of-human-embryonic-stem-cells
#10
Varsha Pursani, Prasad Pethe, Mohsin Bashir, Prabha Sampath, Vivek Tanavde, Deepa Bhartiya
Human embryonic (hES) stem cells are widely used as an in vitro model to understand global genetic and epigenetic changes that occur during early embryonic development. In-house derived hES cells (KIND1) were subjected to directed differentiation into cardiovascular progenitors (D12) and beating cardiomyocytes (D20). Transcriptome profiling of undifferentiated (D0) and differentiated (D12 and 20) cells was undertaken by microarray analysis. ChIP and sequential ChIP were employed to study role of transcription factor NR2F2 during hES cells differentiation...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025589/potential-circulating-mirna-signature-for-early-detection-of-nsclc
#11
Ayda Arab, Morteza Karimipoor, Shiva Irani, Arda Kiani, Sirous Zeinali, Elham Tafsiri, Kambiz Sheikhy
Circulating microRNAs (c-miRNAs) are promising biomarkers for screening, early detection and prognosis of cancer. The purpose of this investigation was to identify a panel of c-miRNAs in plasma that could contribute to early detection of non-small cell lung cancer (NSCLC). We profiled the expression of 44 unique plasma miRNAs in training set of 34 NSCLC patients and 20 matched healthy individuals by miRCURY LNA™ Universal RT microRNA PCR Panel and calculated dysregulation fold changes using the 2-ΔΔCt equation...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29024341/modulation-of-human-subcutaneous-adipose-tissue-microrna-profile-associated-with-changes-in-adiposity-related-parameters
#12
Simona Giardina, Pablo Hernández-Alonso, Jordi Salas-Salvadó, Antoni Rabassa-Soler, Mònica Bulló
SCOPE: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) miRNA profile. METHODS AND RESULTS: 6-month, parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in 8 randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects...
October 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29023006/expression-profile-of-stress-responsive-arabidopsis-thaliana-mirnas-and-their-target-genes-in-response-to-inoculation-with-pectobacterium-carotovorum-subsp-carotovorum
#13
A T Djami-Tchatchou, K Ntushelo
BACKGROUND: Pectobacterium carotovorum subsp. carotovorum (Pcc) is a soft rot bacterium which upon entry into the plant macerates plant tissues by producing plant cell wall degrading enzymes. It has a wide host range which includes carrot, potato, tomato, leafy greens, squash and other cucurbits, onion, green peppers and cassava. During plant-microbe interactions, one of the ways of plant response to pathogen infection is through the small RNA silencing mechanism. Under pathogen attack the plant utilizes microRNAs to regulate gene expression by means of mediating gene silencing at transcriptional and post-transcriptional level...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022896/microrna-378-protects-against-intestinal-ischemia-reperfusion-injury-via-a-mechanism-involving-the-inhibition-of-intestinal-mucosal-cell-apoptosis
#14
Yunsheng Li, Shihong Wen, Xi Yao, Weifeng Liu, Jiantong Shen, Wentao Deng, Jing Tang, Cai Li, Kexuan Liu
Intestinal ischemia/reperfusion (I/R) injury remains a major clinical event and contributes to high morbidity and mortality rates, but the underlying mechanisms remain elusive. Recent studies have demonstrated that microRNAs (miRNAs) have important roles in organ I/R injury, but the changes and potential roles of miRNAs in intestinal I/R-induced intestinal injury are unclear. This study was designed to analyze the miRNA expression profiles in intestinal mucosa after I/R injury and to explore the role of target miRNA during this process...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29022289/cloning-of-autophagy-related-micrornas
#15
Deniz Gulfem Ozturk, Muhammed Kocak, Devrim Gozuacik
Autophagy is a cellular survival pathway that is necessary for the degradation of cellular constituents such as long-lived proteins and damaged organelles. Conditions resulting in cellular stress such as starvation or hypoxia might activate autophagy. Being at the crossroads of various cellular response pathways, dysregulation of autophagy might result in pathological states including cancer and neurodegenerative diseases. Autophagy has also been shown to participate in stemness. MicroRNAs were introduced as novel regulators of autophagy, and accumulating results underlined the fact that they constituted an important layer of biological control mechanism on the autophagic activity...
October 12, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29021694/korean-red-ginseng-extract-induces-angiogenesis-through-activation-of-glucocorticoid-receptor
#16
Wai-Nam Sung, Hoi-Hin Kwok, Man-Hee Rhee, Patrick Ying-Kit Yue, Ricky Ngok-Shun Wong
BACKGROUND: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021386/suppression-of-microrna-activity-in-kidney-collecting-ducts-induces-partial-loss-of-epithelial-phenotype-and-renal-fibrosis
#17
Sachin Hajarnis, Matanel Yheskel, Darren Williams, Thomas Brefort, Bob Glaudemans, Huguette Debaix, Michel Baum, Olivier Devuyst, Vishal Patel
microRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. The physiologic function of these noncoding RNAs in postnatal renal tubules still remains unclear. Surprisingly, they appear to be dispensable for mammalian proximal tubule (PT) function. Here, we examined the effects of miRNA suppression in collecting ducts (CDs). To conclusively evaluate the role of miRNAs, we generated three mouse models with CD-specific inactivation of key miRNA pathway genes Dicer, Dgcr8, and the entire Argonaute gene family (Ago1, 2, 3, and 4)...
October 11, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29018616/integration-of-lncrna-mirna-mrna-reveals-novel-insights-into-oviposition-regulation-in-honey-bees
#18
Xiao Chen, Ce Ma, Chao Chen, Qian Lu, Wei Shi, Zhiguang Liu, Huihua Wang, Haikun Guo
BACKGROUND: The honey bee (Apis mellifera) is a highly diverse species commonly used for honey production and pollination services. The oviposition of the honey bee queen affects the development and overall performance of the colony. To investigate the ovary activation and oviposition processes on a molecular level, a genome-wide analysis of lncRNAs, miRNAs and mRNA expression in the ovaries of the queens was performed to screen for differentially expressed coding and noncoding RNAs. Further analysis identified relevant candidate genes or RNAs...
2017: PeerJ
https://www.readbyqxmd.com/read/29016307/the-differential-expression-and-possible-function-of-long-noncoding-rnas-in-liver-cells-infected-by-dengue-virus
#19
Xiao-Jun Wang, Shi-Chen Jiang, Hai-Xia Wei, Sheng-Qun Deng, Cheng He, Hong-Juan Peng
The function of long noncoding RNAs (lncRNAs) in liver injury resulted by dengue virus (DENV) infection have not yet been explored. The differential expression profiles of lncRNAs coupled with mRNAs in L-02 liver cells in the DENV1 infected, DENV2 infected, and untreated control group were analyzed after high throughput RNA sequencing, the significantly upregulated and downregulated lncRNAs or mRNAs comparing with the control group were identified with a cutoff value at log2 (ratio) ≥ 1.5 and log2 (ratio) ≤ -1...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993685/microrna-profiling-in-lung-tissue-and-bronchoalveolar-lavage-of-cigarette-smoke-exposed-mice-and-in-copd-patients-a-translational-approach
#20
Griet Conickx, Francisco Avila Cobos, Maarten van den Berge, Alen Faiz, Wim Timens, Pieter S Hiemstra, Guy F Joos, Guy G Brusselle, Pieter Mestdagh, Ken R Bracke
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive airflow limitation and is associated with a chronic inflammatory response in both airways and lungs. microRNAs (miRNAs) are often highly conserved between species and have an intricate role within homeostatic conditions and immune responses. Also, miRNAs are dysregulated in smoking-associated diseases. We investigated the miRNA profile of 523 miRNAs by stem-loop RT-qPCR in lung tissue and cell-free bronchoalveolar lavage (BAL) supernatant of mice exposed to air or cigarette smoke (CS) for 4 or 24 weeks...
October 9, 2017: Scientific Reports
keyword
keyword
59367
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"