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https://www.readbyqxmd.com/read/29330759/-autoimmune-reactions-to-immune-checkpoint-inhibitors
#1
REVIEW
W Pönisch, R Alten, C Baerwald
Immune checkpoint inhibitors (ICI) have dramatically changed the face of cancer treatment and are gaining in importance. The ICIs have now been approved for the treatment of advanced cancers, including melanoma, non-small-cell and small cell lung cancers, renal cell carcinoma, Hodgkin's lymphoma, head and neck cancers and urothelial carcinoma and further indications are to be expected. The organs most affected by an autoimmune reaction are the intestines, the musculoskeletal system, skin, endocrine organs, the liver and the lungs...
October 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29330755/-lymphoma-in-rheumatic-diseases
#2
REVIEW
A Rubbert-Roth, J T Bittenbring, G Assmann
Various systemic inflammatory diseases, such as rheumatoid arthritis (RA), Sjögren's syndrome and systemic lupus erythematosus (SLE) are associated with an increased risk for the development of lymphomas. Studies on patients with RA and Sjögren's syndrome have shown that there is a clear association of the incidence of lymphoma with the severity and activity of the disease and lymphomas in particular are diseases which preferentially occur in immunosuppressed patients; therefore, knowledge of the different lymphoma subtypes, their prognosis and treatment options are important for rheumatologists...
October 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29318948/a-comparative-clinical-study-of-temporomandibular-disorder-patients-in-the-otolaryngology-clinic-versus-a-rheumatology-clinic
#3
Kamal G Effat, Abeer Berty
Objective Temporomandibular disorders (TMD) may be associated with local or widespread symptoms, including pain. The aim of this study was to compare clinical features of TMD patients presenting to an otolaryngology clinic with TMD patients presenting to a rheumatology clinic. Methods The study included 107 patients in the otolaryngology setting and 103 patients in the rheumatology setting. A comparison between both groups was made regarding the clinical data. Results Patients in the otolaryngology setting featured more otological symptoms, compared with those in the rheumatology setting...
January 10, 2018: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/29316341/benefits-and-sustainability-of-a-learning-collaborative-for-implementation-of-treat-to-target-in-rheumatoid-arthritis-results-of-the-traction-trial-phase-ii
#4
Daniel H Solomon, Bing Lu, Zhi Yu, Cassandra Corrigan, Leslie R Harrold, Josef S Smolen, Liana Fraenkel, Jeffrey N Katz, Elena Losina
BACKGROUND: We conducted a two-phase randomized controlled trial of a Learning Collaborative (LC) to facilitate implementation of treat to target (TTT) to manage rheumatoid arthritis (RA). We found substantial improvement in implementation of TTT in Phase I. Herein, we report on a second 9 months (Phase II) where we examined maintenance of response in Phase I and predictors of greater improvement in TTT adherence. METHODS: We recruited 11 rheumatology sites and randomized them to either receive the LC during Phase I or to a wait-list control group that received the LC intervention during Phase II...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29310963/guidance-on-noncorticosteroid-systemic-immunomodulatory-therapy-in-noninfectious-uveitis-fundamentals-of-care-for-uveitis-focus-initiative
#5
REVIEW
Andrew D Dick, James T Rosenbaum, Hassan A Al-Dhibi, Rubens Belfort, Antoine P Brézin, Soon Phaik Chee, Janet L Davis, Athimalaipet V Ramanan, Koh-Hei Sonoda, Ester Carreño, Heloisa Nascimento, Sawsen Salah, Sherveen Salek, Jay Siak, Laura Steeples
TOPIC: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. CLINICAL RELEVANCE: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. METHODS: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science)...
January 6, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29303710/vaccinations-in-adults-with-rheumatoid-arthritis-in-an-era-of-new-disease-modifying-anti-rheumatic-drugs
#6
REVIEW
Pier Luigi Meroni, Daniela Zavaglia, Corrado Girmenia
Patients with rheumatoid arthritis are at greater risk of infectious morbidity and mortality due to disease-related abnormalities and use of immunosuppressive medications. Vaccinations are recommended by international guidelines among infection control strategies, but vaccination rates are reported to be still suboptimal in both America and Europe. Furthermore, with the increasing number of immunomodulatory medications used in RA patients, safety and efficacy of vaccinations in RA patients on such therapies have been questioned...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29303700/the-eumusc-net-standards-of-care-for-rheumatoid-arthritis-importance-and-current-implementation-according-to-patients-and-healthcare-providers-in-the-netherlands
#7
Monika Hifinger, Sofia Ramiro, Polina Putrik, Yvonne van Eijk-Hustings, Anthony Woolf, Josef S Smolen, Michaela Stoffer-Marx, Tillman Uhlig, Rikke Helene Moe, Merdan Saritas, Marian Janson, Annette van der Helm-van Mil, Mart van de Laar, Harald Vonkeman, Maarten de Wit, Annelies Boonen
OBJECTIVES: The eumusc.net standards of care (SOCs) for rheumatoid arthritis (RA) aimed to improve quality of care across Europe. This study investigated importance and implementation of each standard according to patients and health care professionals (HCPs) in the Netherlands and identified barriers towards implementation. METHODS: Dutch patients, rheumatologists and rheumatology nurses rated importance and implementation (0-10 numeric rating scale (NRS); 10=most important/best implemented) for each of the 20 SOCs...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29301604/bilateral-choroidal-occlusion-in-antiphospholipid-syndrome-associated-with-systemic-lupus-erythematosus
#8
Yang Zhang, Shun-Hua Zhang, Ai-Ling Bian, You-Xin Chen
This article reports a rare case of bilateral choroidal occlusion that occurred in a 24-year-old woman with antiphospholipid syndrome (APS) associated with systemic lupus erythematosus (SLE). This young lady concurred with aorta ventralis thrombosis and bilateral iliac artery occlusion when presented, and experienced a rapid deterioration of vision. She also has a history of recurrent miscarriage. Corticosteroid, immunosuppression and anticoagulation therapy were administered. Patients with APS associated with SLE are at risk for thrombotic phenomena, which may affect the ocular vessels of all sizes, including choroidal vessel...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29289700/adherence-to-synthetic-disease-modifying-antirheumatic-drugs-in-rheumatoid-arthritis-results-of-the-observar-study
#9
Antonio Juan Mas, Santos Castañeda, José I Cantero Santamaría, José L Baquero, Francisco J Del Toro Santos
BACKGROUND: Treatment compliance with disease-modifying antirheumatic drugs (DMARD) is essential to achieve the therapeutic goals in rheumatoid arthritis (RA). However, despite the need for good compliance, there is evidence that patients with RA frequently fail to use DMARD for the control of RA. Thus, the main objective of the OBSERVAR study is to evaluate the reasons for the lack of therapeutic adherence to synthetic DMARD in these patients. PATIENTS AND METHODS: A Delphi process involving 18 randomly selected Spanish rheumatologists determined the level of agreement with 66 causes of noncompliance selected from the literature in relation to synthetic DMARD in RA...
December 27, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29287308/chikungunya-virus-arthritis-implications-of-acute-and-chronic-inflammation-mechanisms-on-patient-management
#10
REVIEW
Ali Zaid, Patrick Gérardin, Adam Taylor, Helen Mostafavi, Denis Malvy, Suresh Mahalingam
In the past decade, arboviruses - arthropod-borne viruses - have been the focus of public health institutions worldwide following a spate of devastating outbreaks. Chikungunya virus (CHIKV), an arbovirus that belongs to the alphavirus genus, is a re-emerging arthritogenic virus that has caused explosive outbreaks since 2006, notably in the Reunion Island, and more recently in the Caribbean, South America, India and South-East Asia. The severity of arthritic disease caused by CHIKV has prompted public health authorities of affected countries to develop specific guidelines to tackle this pathogen...
December 29, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29282086/mental-health-care-for-youth-with-rheumatologic-diseases-bridging-the-gap
#11
REVIEW
Alaina M Davis, Tamar B Rubinstein, Martha Rodriguez, Andrea M Knight
Youth with rheumatologic diseases have a high prevalence of comorbid mental health disorders. Individuals with comorbid mental health disorders are at increased risk for adverse outcomes related to mental health as well as their underlying rheumatologic disease. Early identification and treatment of mental health disorders has been shown to improve outcomes, but current systems of care fall short in providing adequate mental health services to those in need. Pediatric rheumatologists are uniquely positioned to provide mental health screening and intervention for youth with rheumatologic diseases due to the frequency of patient encounters and ongoing therapeutic relationship with patients and families...
December 28, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29280818/attitudes-toward-and-management-of-fibromyalgia-a-national-survey-of-canadian-rheumatologists-and-critical-appraisal-of-guidelines
#12
Arnav Agarwal, Yvgeniy Oparin, Lauren Glick, Mary-Ann Fitzcharles, Jonathan D Adachi, Matthew D Cooper, Lucas Gallo, Laura Wong, Jason W Busse
BACKGROUND: Canadian rheumatologists' attitudes toward and management of fibromyalgia remain uncertain. OBJECTIVE: The aim of this study was to explore management strategies and attitudes of Canadian rheumatologists toward fibromyalgia and concordance with guideline recommendations. METHODS: We administered a 17-item cross-sectional survey to Canadian rheumatologists and explored the concordance between respondents' management practices with the 2012 Canadian Guidelines for the diagnosis and management of fibromyalgia...
December 27, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29280815/use-of-scribes-for-documentation-assistance-in-rheumatology-and-endocrinology-clinics-impact-on-clinic-workflow-and-patient-and-physician-satisfaction
#13
Maria I Danila, Joshua A Melnick, Jeffrey R Curtis, Nir Menachemi, Kenneth G Saag
BACKGROUND/OBJECTIVE: The aim of this study was to examine the impact of utilizing medical scribes on clinic workflow, physician professional satisfaction, and patient satisfaction in rheumatology and endocrinology clinics. METHODS: We conducted a within-practice pilot study of medical scribes that included a 6-week intervention phase (documentation assistance by medical scribes) followed by a control phase (usual documentation with no assistance) in outpatient rheumatology and endocrinology clinics at an academic medical center...
December 27, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29277578/perceptions-of-patients-with-rheumatic-diseases-treated-with-subcutaneous-biologicals-on-their-level-of-information-rheu-life-survey
#14
Javier de Toro, Luis Cea-Calvo, Enrique Battle, Loreto Carmona, María J Arteaga, Sabela Fernández, Carlos M González
OBJECTIVE: To investigate, in Spanish patients with rheumatic diseases treated with subcutaneous biological drugs, their sources of information, which sources they consider most relevant, and their satisfaction with the information received in the hospital. METHODS: Rheumatologists from 50 hospitals handed out an anonymous survey to 20 consecutive patients with rheumatoid arthritis, axial spondyloarthritis or psoriatic arthritis treated with subcutaneous biologicals...
December 22, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29276462/chiropractic-care-in-the-management-of-inactive-ankylosing-spondylitis-a-case-series
#15
Stacey M Cornelson, David Beavers, Allison Harvey, William Hogarth, Norman W Kettner
Objective: This report describes chiropractic management for 3 cases of inactive ankylosing spondylitis (AS). Clinical Features: A 25-year-old woman presented with chronic, mechanical neck pain and stiffness that was ultimately diagnosed as AS. A 23-year-old man presented with chronic low back and left hip pain that was diagnosed as AS. A 31-year-old man with low back pain presented with a known diagnosis of AS. Physical examination in 2 cases failed to identify systemic findings associated with AS...
December 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29276053/inter-observer-agreement-of-standard-joint-count-examination-and-disease-global-assessment-in-a-cohort-of-egyptian-rheumatoid-arthritis-patients
#16
Khaled El-Hadidi, Sherif M Gamal, Sahar Saad
OBJECTIVES: To assess the inter-observer agreement of standard joint count between experienced Rheumatology professor (Prof) and young Rheumatology fellow (candidate), and to compare disease global assessment between professor, young candidate and patients. METHODS: This study included one hundred rheumatoid arthritis patients. For all patients independent clinical evaluation was done by two rheumatologists (professor and candidate) for detection of tenderness in 28 joints and swelling in 26 joints...
December 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29248952/a-comprehensive-care-program-achieves-high-remission-rates-in-rheumatoid-arthritis-in-a-middle-income-setting-experience-of-a-center-of-excellence-in-colombia
#17
Pedro Santos-Moreno, Nelson J Alvis-Zakzuk, Laura Villarreal-Peralta, Maria Carrasquilla-Sotomayor, Angel Paternina-Caicedo, Nelson Alvis-Guzmán
Management of rheumatoid arthritis (RA) in many Latin-American countries is impaired by fragmentation and scarce healthcare provision, resulting in obstacles to access, diagnosis, and treatment, and consequently in poor health outcomes. The aim of this study is to propose a comprehensive care program as a model to provide healthcare to RA patients receiving synthetic DMARDs in a Colombian setting by describing the model and its results. Health outcomes were prospectively collected in all patients entering the program...
December 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29247348/eosinophilic-fasciitis-during-pregnancy-case-report-and-review-of-literature
#18
REVIEW
Maria Ester Simeira Fonseca, Maria Victória Quaresma, Ana Paula Luppino-Assad, Henrique Carriço da Silva, Danieli Castro O Andrade, Percival D Sampaio-Barros
The authors describe the case of a 23-year-old woman who was referred to the rheumatologist due to symmetrical and progressive stiffness, induration, and swelling of arms and thighs at the 12th week of her first gestation. The characteristic clinical aspect of 'peau d'orange', associated to the histopathologic results of the deep biopsy of the skin confirmed the diagnosis of eosinophilic fasciitis. Treatment with oral prednisone, at an initial dose of 1 mg/kg/day, was effective and rapidly tapered to 10 mg/day till the birth of a healthy newborn...
December 15, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29247150/adiposity-in-juvenile-psoriatic-arthritis
#19
Aaida Samad, Matthew L Stoll, Idit Lavi, Joyce J Hsu, Vibeke Strand, Thomas N Robinson, Elizabeth D Mellins, Devy Zisman
OBJECTIVE: Adult patients with psoriatic arthritis are at increased risk for obesity and metabolic syndrome, but data regarding adiposity in children with juvenile psoriatic arthritis (JPsA) are limited. Our study assessed adiposity in children with JPsA in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry. METHODS: Patients with JPsA in the CARRA registry were divided into nonoverweight and overweight groups using recommendations from the US Centers for Disease Control, and differences in demographic and clinical characteristics between groups at baseline and after 1-year followup were assessed using chi-square test, Fisher's exact test, T test, or Mann-Whitney U test, as appropriate...
December 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29247126/preference-phenotypes-to-facilitate-shared-decision-making-in-rheumatoid-arthritis
#20
Liana Fraenkel, W Benjamin Nowell, George Michel, Carole Wiedmeyer
OBJECTIVE: Implementing treat-to-target (TTT) strategies requires that patients with rheumatoid arthritis (RA) and their rheumatologists decide on how best to escalate care when indicated. The objective of this study was to develop preference phenotypes to facilitate shared decision-making at the point of care for patients failing methotrexate monotherapy. METHODS: We developed a conjoint analysis survey to measure the preferences of patient with RA for triple therapy, biologics and Janus kinase (JAK) inhibitors...
December 15, 2017: Annals of the Rheumatic Diseases
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