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https://www.readbyqxmd.com/read/28929342/perception-of-originator-biologics-and-biosimilars-a-survey-among-belgian-rheumatoid-arthritis-patients-and-rheumatologists
#1
Eline van Overbeeke, Birgit De Beleyr, Jan de Hoon, Rene Westhovens, Isabelle Huys
BACKGROUND: Among patients and rheumatologists, current knowledge and perception of biosimilars in comparison with originator biologics is unknown. OBJECTIVES: The aim of this study was to investigate this knowledge and perception in Belgian rheumatologists and rheumatoid arthritis (RA) patients. METHODS: Anonymous web surveys were conducted in Belgian RA patients (n = 121) and rheumatologists (n = 41) during the period January-March 2016...
September 19, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28929232/-prevalence-comorbidity-and-interdisciplinary-treatment-of-rheumatoid-arthritis-insurance-data-on-outpatient-and-inpatient-care-in-baden-w%C3%A3-rttemberg
#2
A Strahl, O Schneider, J Frankenhauser-Mannuß, S Knapstein, C Hermann, B Lembeck, H-M Lorenz, W Rüther, J Flechtenmacher
BACKGROUND: Rheumatoid arthritis (RA) has an increased number of comorbidities compared with the general population. OBJECTIVE: Study aim was to collect epidemiological data on prevalence, incidence and comorbidities of RA as well as utilization of outpatient and inpatient care services. MATERIAL AND METHODS: In an age and gender-adjusted case control study, a total of 3.4 million patients insured by the AOK Baden-Württemberg were analysed with respect to visits to physicians, prevalence, incidence and comorbidities of RA...
September 19, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28928270/the-evolving-role-of-the-rheumatologist-in-the-management-of-immune-related-adverse-events-iraes-caused-by-cancer-immunotherapy
#3
EDITORIAL
Leonard Calabrese, Xavier Mariette
The rapid introduction of immunotherapies for cancer-targeting immunological checkpoints has led to a new class of toxicities that appear to be of autoimmune and or autoinflammatory origin. These disorders are now referred to as immune-related adverse events (irAEs) and pose considerable challenges to patient care in terms of how to optimally manage these formidable toxicities while allowing effective antitumoural therapy to continue. While rheumatologists will naturally be called on to manage those irAEs of rheumatic origin, we believe there is a need and an opportunity for rheumatologists to participate as central figures in this evolving field, in large part because of our familiarity with multiorgan autoimmune disease and our expertise in crafting and utilising both traditional and biological immune-based therapies...
September 19, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28926466/barriers-impeding-the-use-of-non-pharmacological-non-surgical-care-in-hip-and-knee-osteoarthritis-the-views-of-general-practitioners-physical-therapists-and-medical-specialists
#4
Ellen M H Selten, Johanna E Vriezekolk, Marc W Nijhof, Henk J Schers, Roelien G van der Meulen-Dilling, Willemijn H van der Laan, Rinie Geenen, Cornelia H M van den Ende
BACKGROUND: Non-pharmacological, non-surgical treatment modalities are underused in the management of knee and hip osteoarthritis (OA). One possible explanation for this could be healthcare providers' opinions about these treatment modalities. The objective of this qualitative study was to identify healthcare providers' views on non-pharmacological, non-surgical care for OA. METHODS: Semi-structured in-depth interviews with 24 healthcare providers (rheumatologists, orthopedic surgeons, physical therapists and general practitioners) were held...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28919914/agreement-of-clinical-examination-and-ultrasound-methods-for-detection-of-joints-involvements-in-rheumatoid-arthritis
#5
Hadi Karimzadeh, Ramin Rafiei, Zahra Sayedbonakdar, Mehdi Karami
BACKGROUND: Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial tissue inflammation and destruction of articular components which if not controlled properly, can cause disability in patients. For this reason, evaluation of disease activity and its control is very important. In recent years using sonography is promising for the evaluation of disease activity. This study aimed to compare "clinical examination" and "ultrasonography" methods in the detection of disease activity in patients with rheumatoid arthritis...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28917712/toward-classification-criteria-for-early-osteoarthritis-of-the-knee
#6
F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander
OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document...
August 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28917218/erythema-elevatum-diutinum-in-crohn-s-disease-associated-spondyloarthritis-a-rare-vasculitis-an-unusual-association
#7
Maria João Gonçalves, Vasco C Romão, Luís Soares-de-Almeida, Helena Canhão, José Carlos Romeu, Heinz Kutzner, José Alberto Pereira-da-Silva
Erythema elevatum diutinum is a rare neutrophilic dermatoses with vasculitis, which presents as persistent, symmetrical, purple or brownish papules and nodules, mainly in the extensor surface of the limbs. We describe a case of erythema elevatum diutinum and polyarthritis as initial manifestations of Crohn's disease associated spondyloarthritis. A 51-year-old man, from São Tomé e Príncipe, with previous history of treated tuberculosis and chronic hepatitis B infection, was admitted due to 4 months history of polyarthritis, hyperpigmented papules on the extensor surfaces, occasional episodes of bloody mucous diarrhea and significant weight loss...
September 14, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28916546/approach-to-membranous-lupus-nephritis-a-survey-of-pediatric-nephrologists-and-pediatric-rheumatologists
#8
Alexis Boneparth, Suhas M Radhakrishna, Larry A Greenbaum, Eric Yen, Daryl M Okamura, Jennifer C Cooper, Sherene Mason, Deborah M Levy, Sangeeta D Sule, Paul T Jensen, Cagri Yildirim-Toruner, Stacy P Ardoin, Scott E Wenderfer
OBJECTIVE: To describe treatment practices for childhood pure membranous lupus nephritis (MLN). METHODS: Survey study of Childhood Arthritis and Rheumatology Research Alliance and American Society of Pediatric Nephrology members. RESULTS: There were 117 respondents who completed the survey (60 pediatric nephrologists, 57 pediatric rheumatologists). Steroids and nonsteroid immunosuppression (NSI) were routinely used by the majority for MLN...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28916114/-scleritis-and-episcleritis
#9
REVIEW
E Héron, T Bourcier
Episcleritis is generally a benign disease with a self-limited course, while scleritis is a severe ocular condition due to a risk of impaired vision in one-fifth of patients and its association with systemic diseases in one third of them. Infectious scleritis, representing 8 % of the etiologies, is mainly of herpetic origin (varicella zoster and herpes simplex viruses). A systemic autoimmune disease is observed in roughly 30 % of scleritis patients: inflammatory rheumatisms (15 %), firstly rheumatoid polyarthritis, systemic vasculitides (8 %), mainly granulomatosis with polyangiitis (Wegener's) and polychondritis, and less often inflammatory bowel disease and systemic lupus erythematosus...
September 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28912960/influence-of-disease-activity-on-ra-treatment-choices-in-countries-with-restricted-access-to-expensive-innovative-drugs-a-discrete-choice-experiment-among-rheumatologists
#10
Monika Hifinger, Mickael Hiligsmann, Sofia Ramiro, Verity Watson, Florian Berghea, Márta Péntek, Andrew Keat, Johan L Severens, Bruno Fautrel, Annelies Boonen
OBJECTIVE: To assess the influence of disease activity of patients with rheumatoid arthritis on treatment choices of rheumatologists in countries with restricted access to expensive, innovative drugs. METHODS: Rheumatologists from Hungary, Romania and UK were invited to complete two consecutive discrete choice experiments with hypothetical drug treatments for two different patient profiles: high and moderate disease activity. Rheumatologists were asked to choose repeatedly between two unlabelled treatment options that differed in five attributes: efficacy (expected improvement and achieved disease activity state), safety (probability of serious adverse events), patient's preference (level of agreement), total medication costs and cost-effectiveness...
2017: RMD Open
https://www.readbyqxmd.com/read/28911936/exercise-training-in-patients-with-pulmonary-and-systemic-hypertension-a-unique-therapy-for-two-different-diseases
#11
REVIEW
Massimo Leggio, Augusto Fusco, Giorgio Limongelli, Luca Sgorbini
Pulmonary hypertension is a potentially life-threatening condition. Given its evolving definition, the incidence and prevalence of the disease is difficult to define, but registries suggest an increased global awareness. The management of patients with pulmonary arterial hypertension is highly specialised and requires multi-disciplinary input from a range of healthcare professionals, including cardiologists, respiratory physicians, rheumatologists, rehabilitation physicians and cardio-pulmonary physiotherapists...
September 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28904038/facilitated-access-to-an-integrated-model-of-care-for-arthritis-in-an-urban-aboriginal-population
#12
Cheryl Barnabe, Stacy Lockerbie, Elizabeth Erasmus, Lynden Crowshoe
OBJECTIVE: To evaluate a model of care to improve arthritis detection and treatment in an urban Aboriginal population. DESIGN: Cohort study. SETTING: The Elbow River Healing Lodge in Calgary, Alta. PARTICIPANTS: A total of 26 participants with noninflammatory arthritis and 12 with inflammatory arthritis. INTERVENTION: A monthly rheumatology clinic was embedded in the primary health care service and received referrals from primary care providers and allied health care professionals, or self-referrals...
September 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28903545/the-road-from-development-to-approval-evaluating-the-body-of-evidence-to-confirm-biosimilarity
#13
Paul Declerck, Mourad Farouk Rezk
Biosimilars are products that contain a similar version of the active substance of an already authorized original biologic medicinal product (reference medicinal product). Their development requires special consideration, as similarity to the reference agent needs to be established through a comprehensive comparability exercise. Given the complex nature of these agents, minor structural differences may emerge, but the process of biosimilarity determination is designed to ascertain that the nature and impact of these differences are not clinically significant...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28894946/an-international-survey-on-non-invasive-techniques-to-assess-the-microcirculation-in-patients-with-raynaud-s-phenomenon-sunshine-survey
#14
Francesca Ingegnoli, Nicola Ughi, Graham Dinsdale, Annalisa Orenti, Patrizia Boracchi, Yannick Allanore, Ivan Foeldvari, Alberto Sulli, Maurizio Cutolo, Vanessa Smith, Ariane L Herrick
To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud's phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapillaroscopy (NVC), dermoscopy, stereomicroscopy, digital USB microscopy], four laser Doppler methods (laser Doppler flowmetry, imaging, anemometry/velocimetry, laser speckle contrast analysis), thermographic imaging, and upper limb arterial Doppler ultrasound. Emails with a link to the survey were sent to physicians from the European Scleroderma Trials and Research group (EUSTAR), the EULAR Study Group on Microcirculation in Rheumatic Diseases (SG_MC/RD) and members of the pediatric rheumatology Email board...
September 11, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28894080/the-portuguese-society-of-rheumatology-position-paper-on-the-use-of-biosimilars-2017-update
#15
Filipe C Araújo, Alexandre Sepriano, Filipa Teixeira, Diogo Jesus, Teresa Martins Rocha, Patrícia Martins, Catarina Tenazinha, Ana Cordeiro, Ana Filipa Mourão, Cândida Silva, Carlos Vaz, Cátia Duarte, Cristina Ponte, Fernando Pimentel Dos Santos, Helena Canhão, Helena Santos, José Bravo Pimentão, José Canas da Silva, Joaquim Pereira, José António Pereira da Silva, Luís Cunha Miranda, Margarida Oliveira, Maria João Saavedra, Pedro Gonçalves, Sandra Falcão, Susana Capela, João Eurico Fonseca
Biosimilars are new and more affordable similar versions of previously approved reference biological drugs. Following the approval of the first monoclonal antibody biosimilar in 2013, the Portuguese Society of Rheumatology issued a position paper on the use of biosimilars in rheumatic conditions covering efficacy, safety, extrapolation, interchangeability, substitution and pharmacovigilance. However, as this is a rapidly evolving field, it was felt that the knowledge and evidence gathered since then justified an update of these statements...
July 21, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28894079/portuguese-recommendations-for-the-use-of-biological-therapies-in-patients-with-axial-spondyloarthritis-2016-update
#16
Pedro Machado, Marcos Cerqueira, Pedro Ávila-Ribeiro, Renata Aguiar, Alexandra Bernardo, Alexandre Sepriano, Ana Águeda, Ana Cordeiro, Ana Raposo, Ana M Rodrigues, Anabela Barcelos, Armando Malcata, Carina Lopes, Cláudia Vaz, Dolores Nour, Fátima Godinho, Fernando Alvarenga, Fernando Pimentel-Santos, Helena Canhão, Helena Santos, Inês Cunha, Joana Sousa Neves, João Eurico Fonseca, João Lagoas Gomes, José Tavares-Costa, Lúcia Costa, Luís Cunha-Miranda, Luís Maurício, Margarida Cruz, Maria Carmo Afonso, Maria José Santos, Miguel Bernardes, Paula Valente, Ricardo Figueira, Sofia Pimenta, Sofia Ramiro, Teresa Pedrosa, Tiago Afonso Costa, Elsa Vieira-Sousa
OBJECTIVE: To update the recommendations for the treatment of axial spondyloarthritis (axSpA) with biological therapies, endorsed by the Portuguese Society of Rheumatology. METHODS: These treatment recommendations were formulated by Portuguese rheumatologists based on literature evidence and consensus opinion. At a national meeting, the 7 recommendations included in this document were discussed and updated. A draft of the full text of the recommendations was then circulated and suggestions were incorporated...
June 25, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28893220/the-added-value-of-musculoskeletal-ultrasound-to-clinical-evaluation-in-the-treatment-decision-of-rheumatoid-arthritis-outpatients-physician-experience-matters
#17
C Sifuentes-Cantú, I Contreras-Yáñez, L Saldarriaga, A C Lozada, M Gutiérrez, V Pascual-Ramos
BACKGROUND: Musculoskeletal ultrasound improves the accuracy of detecting the level of disease activity (DA) in RA patients, although its impact on the final treatment decision in a real clinical setting is uncertain. The objectives were to define the percentage of clinical scenarios from an ongoing cohort of RA outpatients in which the German Ultrasound Score on 7 joints (GUS-7) impacted the treatment and to explore if the impact differed between a senior rheumatologist (SR) vs. a trainee (TR)...
September 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28891252/the-incidence-and-prevalence-of-systemic-lupus-erythematosus-in-new-york-county-manhattan-new-york-the-manhattan-lupus-surveillance-program
#18
Peter M Izmirly, Isabella Wan, Sara Sahl, Jill P Buyon, H Michael Belmont, Jane E Salmon, Anca Askanase, Joan M Bathon, Laura Geraldino-Pardilla, Yousaf Ali, Ellen M Ginzler, Chaim Putterman, Caroline Gordon, Charles G Helmick, Hilary Parton
OBJECTIVE: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of systemic lupus erythematosus (SLE) in 2007 and the incidence from 2007 to 2009 among residents of New York County (Manhattan), New York, and to characterize cases by race/ethnicity, including Asians and Hispanics, for whom data are lacking. METHODS: We identified possible SLE cases from hospital records, rheumatologist records, and administrative databases...
September 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28891237/the-incidence-and-prevalence-of-systemic-lupus-erythematosus-in-san-francisco-county-california-the-california-lupus-surveillance-project
#19
Maria Dall'Era, Miriam G Cisternas, Kurt Snipes, Lisa J Herrinton, Caroline Gordon, Charles G Helmick
OBJECTIVE: Estimates of the incidence and prevalence of systemic lupus erythematosus (SLE) in the US have varied widely. The purpose of this study was to conduct the California Lupus Surveillance Project (CLSP) to determine credible estimates of SLE incidence and prevalence, with a special focus on Hispanics and Asians. METHODS: The CLSP, which is funded by the Centers for Disease Control and Prevention, is a population-based registry of individuals with SLE residing in San Francisco County, CA, from January 1, 2007 through December 31, 2009...
September 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28882616/screening-of-inflammatory-bowel-disease-and-spondyloarthritis-for-referring-patients-between-rheumatology-and-gastroenterology
#20
Jesús Sanz Sanz, Xavier Juanola Roura, Daniel Seoane-Mato, Miguel Montoro, Fernando Gomollón
OBJECTIVE: To define clinical screening criteria for spondyloarthritis (SpA) in patients with inflammatory bowel disease (IBD) and vice versa, which can be used as a reference for referring them to the rheumatology or gastroenterology service. METHOD: Systematic literature review and a two-round Delphi method. The scientific committee and the expert panel were comprised of 2 rheumatologists and 2 gastroenterologists, and 7 rheumatologists and 7 gastroenterologists, respectively...
September 4, 2017: Gastroenterología y Hepatología
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