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Gender differences and relationships

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https://www.readbyqxmd.com/read/29332331/egfr-mutations-and-tumor-metastases-in-patients-with-nonsmall-cell-lung-cancer-in-the-south-of-russia
#1
Oleg I Kit, Dmitry I Vodolazhsky, Natalia N Timoshkina, Lubov' Yu Vladimirova, Igor N Turkin, Ksenia A Kutsyn, Yaroslav S Enin, Svetlana B Panina, Vladimir Jurisic
PURPOSE: To assess the frequencies of somatic EGFR mutations in the tumor tissues of patients with non-small cell lung cancer (NSCLC) residing in the South of Russia (SR), and to define the relationship between genetic subtypes of NSCLC and the emergence of different types of metastases. METHODS: DNA was extracted from formalin-fixed parrafin embedded (FFPE) samples of 721 patients. A total of 29 somatic EGFR mutations were detected using commercial Therascreen EGFR RGQ PCR Kit...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331875/the-association-between-vitamin-d-receptor-polymorphisms-and-multiple-sclerosis-in-a-turkish-population
#2
Ozden Kamisli, Ceren Acar, Mert Sozen, Mehmet Tecellioglu, Fatma Ebru Yücel, Dilara Vaizoglu, Cemal Özcan
BACKGROUND: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. METHODS: 167 MS patients and 146 healthy control subjects were included in the present study...
January 9, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29330930/gender-specific-risk-factors-for-androgenetic-alopecia-in-the-korean-general-population-associations-with-medical-comorbidities-and-general-health-behaviors
#3
Bo-Kyung Kim, Sung Jay Choe, Hee-Chul Chung, Sung-Soo Oh, Won-Soo Lee
BACKGROUND: The relationships between androgenetic alopecia (AGA) and various factors related to metabolic syndrome have been demonstrated in previous studies. However, it remains unclear because of inconsistent results. We investigated the associations between AGA and various risk factors related to metabolic syndrome according to gender. METHODS: We conducted a population-based cross-sectional survey of 2028 Koreans (1050 men, 978 women). The basic and specific (BASP) classification was used for diagnosis of AGA...
February 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29330633/a-seven-center-examination-of-the-relationship-between-monthly-volume-and-mortality-in-trauma-a-hypothesis-generating-study
#4
Stanislaw P Stawicki, Keith Habeeb, Niels D Martin, M Shay O'Mara, James Cipolla, David C Evans, Creagh Boulger, Babak Sarani, Charles H Cook, Alok Gupta, William S Hoff, Peter G Thomas, Jeffrey M Jordan, Weidun Alan Guo, Mark J Seamon
INTRODUCTION: The relationship between trauma volumes and patient outcomes continues to be controversial, with limited data available regarding the effect of month-to-month trauma volume variability on clinical results. This study examines the relationship between monthly trauma volume variations and patient mortality at seven Level I Trauma Centers located in the Eastern United States. We hypothesized that higher monthly trauma volumes may be associated with lower corresponding mortality...
January 12, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29330577/asymptomatic-population-reference-values-for-three-knee-patient-reported-outcomes-measures-evaluation-of-an-electronic-data-collection-system-and-implications-for-future-international-multi-centre-cohort-studies
#5
James M McLean, Oscar Brumby-Rendell, Ryan Lisle, Jacob Brazier, Kieran Dunn, Tiffany Gill, Catherine L Hill, Daniel Mandziak, Jordan Leith
OBJECTIVES: The aim was to assess whether the Knee Society Score, Oxford Knee Score (OKS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) were comparable in asymptomatic, healthy, individuals of different age, gender and ethnicity, across two remote continents. The purpose of this study was to establish normal population values for these scores using an electronic data collection system. HYPOTHESIS: There is no difference in clinical knee scores in an asymptomatic population when comparing age, gender and ethnicity, across two remote continents...
January 12, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29329793/drug-use-family-support-and-related-factors-in-university-students-a-cross-sectional-study-based-on-the-unihcos-project-data
#6
Jorge Arias-De la Torre, Tania Fernández-Villa, Antonio José Molina, Carmen Amezcua-Prieto, Ramona Mateos, José María Cancela, Miguel Delgado-Rodríguez, Rocío Ortíz-Moncada, Juan Alguacil, Ana Almaraz, Inés Gómez-Acebo, María Morales Suárez-Varela, Gemma Blázquez-Abellán, Eladio Jiménez-Mejías, Luis Félix Valero, Carlos Ayán, Laura Vilorio-Marqués, Rocío Olmedo-Requena, Vicente Martín
OBJECTIVE: To assess the prevalence of illegal drug use in college students on any previous occasion, during the previous year and the previous month, and to analyze the relationship between illegal drug use and family support and other factors. METHODS: A cross-sectional study using data from students participating in the uniHcos project (n = 3767) was conducted. The prevalence and age of onset of consumption of cannabis, non-prescription sedatives, stimulants and depressants was evaluated...
January 9, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29327230/alcohol-alcoholic-beverages-and-melanoma-risk-a-systematic-literature-review-and-dose-response-meta-analysis
#7
REVIEW
Sara Gandini, Giovanna Masala, Domenico Palli, Benedetta Cavicchi, Calogero Saieva, Ilaria Ermini, Federica Baldini, Patrizia Gnagnarella, Saverio Caini
PURPOSE: Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose-response meta-analysis of studies published until June 30th, 2017, that examined the association between alcohol intake (overall and by beverage type) and melanoma risk. METHODS: We used random effect models with maximum likelihood estimation to calculate summary relative risk (SRR) and 95% confidence intervals (95%CI)...
January 11, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29326500/a-comparative-evaluation-between-cheiloscopic-patterns-and-terminal-planes-in-primary-dentition
#8
R Vignesh, C Vishnu Rekha, Sankar Annamalai, Parisa Norouzi, Ditto Sharmin
Objective: To assess the correlation between different cheiloscopic patterns with the terminal planes in deciduous dentition. Materials and Methods: Three hundred children who are 3-6 years old with complete primary dentition were recruited, and the pattern of molar terminal plane was recorded in the pro forma. Lip prints of these children were recorded with lipstick-cellophane method, and the middle 10 mm of lower lip was analyzed for the lip print pattern as suggested by Sivapathasundharam et al...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326420/fasting-and-glucose-induced-thermogenesis-in-response-to-three-ambient-temperatures-a-randomized-crossover-trial-in-the-metabolic-syndrome
#9
K Pathak, R J Woodman, A P James, M J Soares
BACKGROUND/OBJECTIVES: Cold exposure increases thermogenesis and could improve insulin sensitivity. We hypothesized a blunted response in the metabolic syndrome (MetS). SUBJECTS/METHODS: Twenty older adults 59 ± 10.4 years (with MetS, MetS+, n = 9; without MetS, MetS-, n = 11) completed a randomized crossover design of 3.5 h exposures to 20, 25 and 27 °C on three visits. After an hour's rest at the desired temperature, resting metabolic rate (RMR), respiratory quotient (RQ), forearm to fingertip gradients (FFG), and in the ear temperature (IET) were measured over 30 min...
January 11, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29326069/positive-correlation-between-rat-brain-glutamate-concentrations-and-mitochondrial-2-oxoglutarate-dehydrogenase-activity
#10
Garik V Mkrtchyan, Anastasia Graf, Lidia Trofimova, Alexander Ksenofontov, Ludmila Baratova, Victoria Bunik
Glutamate is a key metabolite and major excitatory neurotransmitter, degraded through transformation to 2-oxoglutarate which is further catabolized by 2-oxoglutarate dehydrogenase complex (OGDHC). Both the glutamate excitotoxicity and impaired OGDHC activity are hallmarks of neurodegeneration. This work quantifies a relationship between the brain OGDHC activity and glutamate levels, assessing its diagnostic value to characterize (patho)physiology. A moderate to strong positive correlation of the two parameters determined under varied physiological settings (brain regions, seasons, gender, pregnancy, rat line), is revealed...
January 8, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29325836/interleukin-6-and-leptin-levels-are-associated-with-preoperative-pain-severity-in-patients-with-osteoarthritis-but-not-with-acute-pain-after-total-knee-arthroplasty
#11
Syed Azim, James Nicholson, Mario J Rebecchi, William Galbavy, Tian Feng, Sabeen Rizwan, Ruth A Reinsel, Martin Kaczocha, Helene Benveniste
BACKGROUND: Identifying drivers of pain that can serve as novel drug targets is important for improving perioperative analgesia. Total knee arthroplasty (TKA) is associated with significant postoperative pain. Cytokines contribute to the pathophysiology of osteoarthritis (OA) and associated pain. However, the influence of perioperative cytokine levels after TKA surgery upon postoperative pain remains unexplored. METHODS: We designed a prospective observational study to profile three proinflammatory cytokines, interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and leptin in serum, synovial, and cerebrospinal fluid of TKA patients perioperatively to determine associations between cytokine levels and pain...
January 8, 2018: Knee
https://www.readbyqxmd.com/read/29325247/-impact-of-prdm1-gene-inactivation-on-c-myc-regulation-in-diffuse-large-b-cell-lymphoma
#12
X Y Zhang, Z P Ma, W L Cui, X L Pang, R Chen, L Wang, W Zhang, X X Li
Objective: To investigate the role of PRDM1 gene inactivaion in the regulation of C-MYC in diffuse large B-cell lymphoma (DLBCL), and to explore the correlation of its immunophenotype and prognosis. Methods: 100 cases paraffin-embedded DLBCL tissues were collected from January 2009 to December 2015 at the First Affiliated Hospital of Xinjiang Medical University along with 20 cases of reactive proliferative lymph nodes as control. Immunohistochemical methods were used to detect the expression of CD20, CD10, MUM1, Ki-67, bcl-6, PRDM1/Blimp1, C-MYC and PAX5 protein...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29325105/predictors-of-secondary-role-strains-among-spousal-caregivers-of-older-adults-with-functional-disability
#13
Courtney A Polenick, Nicole DePasquale
Background and Objectives: Aging spouses commonly care for a partner with functional disability, but little is known about how spousal caregiving may impact different life domains. This study evaluated how caregiving characteristics are associated with secondary role strains among spousal caregivers. Research Design and Methods: This cross-sectional study examined 367 spousal caregivers and their partners from the 2011 National Health and Aging Trends Study and National Study of Caregiving...
January 8, 2018: Gerontologist
https://www.readbyqxmd.com/read/29324177/tobacco-use-among-adults-by-sexual-orientation-findings-from-the-population-assessment-of-tobacco-and-health-study
#14
Christopher W Wheldon, Annette R Kaufman, Karin A Kasza, Richard P Moser
PURPOSE: The aim of this study was to characterize lifetime tobacco use across two measures of sexual orientation and six types of tobacco products. METHODS: We conducted a cross-sectional analysis of the Population Assessment of Tobacco and Health (Wave 1, 2013-2014, USA) to estimate the prevalence of tobacco use (cigarettes, e-cigarettes, cigars, pipes, hookah, and smokeless) stratified by gender (men/women), age (< 25/≥ 25 years old), and sexual orientation...
January 2018: LGBT Health
https://www.readbyqxmd.com/read/29324175/radiation-and-age-associated-changes-in-peripheral-blood-dendritic-cell-populations-among-aging-atomic-bomb-survivors-in-japan
#15
Junko Kajimura, Heather E Lynch, Susan Geyer, Benjamin French, Mika Yamaoka, Ivo D Shterev, Gregory D Sempowski, Seishi Kyoizumi, Kengo Yoshida, Munechika Misumi, Waka Ohishi, Tomonori Hayashi, Kei Nakachi, Yoichiro Kusunoki
Previous immunological studies in atomic bomb survivors have suggested that radiation exposure leads to long-lasting changes, similar to immunological aging observed in T-cell-adaptive immunity. However, to our knowledge, late effects of radiation on dendritic cells (DCs), the key coordinators for activation and differentiation of T cells, have not yet been investigated in humans. In the current study, we hypothesized that numerical and functional decreases would be observed in relationship to radiation dose in circulating conventional DCs (cDCs) and plasmacytoid DCs (pDCs) among 229 Japanese A-bomb survivors...
January 2018: Radiation Research
https://www.readbyqxmd.com/read/29323228/relationships-between-type-of-pain-and-work-participation-in-people-with-long-standing-spinal-cord-injury-results-from-a-cross-sectional-study
#16
Ellen H Roels, Michiel F Reneman, Janneke Stolwijk-Swuste, Charlotte C van Laake-Geelen, Sonja de Groot, Jacinthe J E Adriaansen, Marcel W M Post
STUDY DESIGN: Multicentre, cross-sectional study. OBJECTIVES: To describe the relationships between the presence of (different types of) pain and participation in paid work in people with long-standing spinal cord injury (SCI). Furthermore, the associations of pain-related work limitations, age, gender, relationship, education, lesion level, and time since injury (TSI) with work participation (WP) were investigated. SETTING: The Netherlands...
January 11, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29320970/modelling-endurance-and-resumption-times-for-repetitive-one-hand-pushing
#17
Linda M Rose, Catherine A A Beauchemin, W Patrick Neumann
This study's objective was to develop models of endurance time (ET), as a function of load level (LL), and of resumption time (RT) after loading as a function of both LL and loading time (LT) for repeated loadings. Ten male participants with experience in construction work each performed fifteen different one-handed repetaed pushing tasks at shoulder height with varied exerted force and duration. This data was used to create regression models predicting ET and RT. It is concluded that power law relationships are most appropriate to use when modelling ET and RT...
January 11, 2018: Ergonomics
https://www.readbyqxmd.com/read/29319844/gender-differences-in-intimate-conflict-initiation-and-escalation-tendencies
#18
Zeev Winstok, Ronit Smadar-Dror, Michael Weinberg
According to gender motivation theory, men are driven by a desire to enhance their status; whereas, women are motivated by a desire to reduce risk, and the behavioral expressions of those motivations are context-dependent. In order to test this theory in the context of intimate relationships, this study compared men's and women's escalatory tendencies in the initial development of intimate conflict. These tendencies were conceptualized in terms of four attributes: two attributes that represent response intention (decision and style) and two others that represent motivations for that intention (putting one's partner in his or her place and avoiding conflict)...
January 10, 2018: Aggressive Behavior
https://www.readbyqxmd.com/read/29317657/blood-plasma-igg-n-glycome-biosignatures-associated-with-major-depressive-disorder-symptom-severity-and-the-antidepressant-response
#19
Dong Ik Park, Jerko Štambuk, Genadij Razdorov, Maja Pučić-Baković, Daniel Martins-de-Souza, Gordan Lauc, Christoph W Turck
While N-linked glycosylation has been extensively studied in the context of inflammatory and metabolic disorders, its relationship with major depressive disorder (MDD) and antidepressant treatment response has not been investigated. In our exploratory study, we analysed N-glycan profiles in blood plasma samples collected from MDD patients (n = 18) and found gender-dependent correlations with severity of depressive symptoms prior to initiating antidepressant treatment. In addition, several N-glycosylation traits showed gender-dependent associations with clinical antidepressant response...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316618/trajectories-of-emotional-symptoms-and-peer-relationship-problems-in-children-after-nuclear-disaster-evidence-from-the-fukushima-health-management-survey
#20
Misari Oe, Masaharu Maeda, Tetsuya Ohira, Shuntaro Itagaki, Mayumi Harigane, Yuriko Suzuki, Hirooki Yabe, Seiji Yasumura, Kenji Kamiya, Hitoshi Ohto
The Fukushima Daiichi Nuclear Power Plant accident, which occurred in March 2011, is having long-term effects on children. We planned this study to describe the trajectories of emotional symptoms and peer relationship problems in children and to examine potential risks and protective factors over the 35 months following the accident. The sample was 11,791 children in the first to sixth elementary grades. We identified four patterns for emotional symptoms and three patterns for peer relationship problems, using group-based trajectory modelling...
January 6, 2018: International Journal of Environmental Research and Public Health
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