Younes Medkour, Karamat Mohammad, Anthony Arlia-Ciommo, Veronika Svistkova, Pamela Dakik, Darya Mitrofanova, Monica Enith Lozano Rodriguez, Jennifer Anne Baratang Junio, Tarek Taifour, Paola Escudero, Fani-Fay Goltsios, Sahar Soodbakhsh, Hana Maalaoui, Éric Simard, Vladimir I Titorenko
We have recently found that PE21, an extract from the white willow Salix alba , slows chronological aging and prolongs longevity of the yeast Saccharomyces cerevisiae more efficiently than any of the previously known pharmacological interventions. Here, we investigated mechanisms through which PE21 delays yeast chronological aging and extends yeast longevity. We show that PE21 causes a remodeling of lipid metabolism in chronologically aging yeast, thereby instigating changes in the concentrations of several lipid classes...
October 8, 2019: Oncotarget