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Tanacetum parthenium (feverfew)

Krisztina Végh, Eszter Riethmüller, Levente Hosszú, András Darcsi, Judit Müller, Ágnes Alberti, Anita Tóth, Szabolcs Béni, Árpád Könczöl, György Tibor Balogh, Ágnes Kéry
Feverfew (Tanacetum parthenium L.) as a perennial herb has been known for centuries due to its medicinal properties. The main sesquiterpene lactone, parthenolide is considered to be responsible for the migraine prophylactic effect, however the pharmacological benefits of the lipophilic flavonoid components can not be neglected. Supercritical fluid extraction (7% ethanol, 22MPa, 64°C) was carried out on the leaves of Tanacetum parthenium L. from which the presence of methylated flavonoids beside parthenolide and other sesquiterpene lactones were indicated by preliminary LC-MS analyses...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Angèle Guilbot, Marie Bangratz, Samira Ait Abdellah, Christian Lucas
BACKGROUND: Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in an observational study. METHODS: Adult patients suffering from migraine according to the criteria of the International Headache Society were enrolled by general practitioners (≥2 migraine attacks during previous month; exclusion of chronic migraine and medication overuse) and after a one-month baseline phase, supplemented with one tablet of 100 mg feverfew, 100 mg coenzyme Q10 and 112...
August 30, 2017: BMC Complementary and Alternative Medicine
Yu Chuan Liu, Se Lim Kim, Young Ran Park, Soo-Teik Lee, Sang Wook Kim
BACKGROUND/AIMS: Parthenolide (PT), a principle component derived from feverfew (Tanacetum parthenium), is a promising anticancer agent and has been shown to promote apoptotic cell death in various cancer cells. In this study, we focused on its functional role in apoptosis, migration, and invasion of human colorectal cancer (CRC) cells. METHODS: SW620 cells were employed as representative human CRC cells. We performed the MTT assay and cell cycle analysis to measure apoptotic cell death...
April 2017: Intestinal Research
Mostafa Hojati, Seyed Ali Mohammad Modarres-Sanavy, Sattar Tahmasebi Enferadi, Mohammad Majdi, Faezeh Ghanati, Soudeh Farzadfar, Alireza Pazoki
Morphological and biochemical responses of feverfew plants exposed to low (5 μM) and high (35 and 70 μM) levels of Cd or Cu were investigated. Increasing metal supply notably reduced the plant biomass. Elevated Cd and Cu levels also resulted in an increase in the leaf proline content. Besides, decrease in ascorbic acid (AsA) and glutathione (GSH) contents was similar in the leaves of Cd- and Cu-treated plants, indicating altered biosynthesis of AsA and GSH under metal excess. High metal doses stimulated increase in antioxidative enzyme activities that could be related to elevated hydrogen peroxide (H2O2) content and subsequent lipid peroxidation...
May 2017: Environmental Science and Pollution Research International
Jun-Feng Zhang, Li Zhang, Li-Li Shi, Zhao-Hua Zhao, Hao Xu, Fei Liang, Hong-Bo Li, Yan Zhao, Xi Xu, Ke Yang, Ying-Fang Tian
Parthenolide (PN), a sesquiterpene lactone isolated from the herbal medicine feverfew (Tanacetum parthenium), was reported to possess neuroprotective activity. However, the neuroprotective effect of PN against cerebral ischemia/reperfusion (I/R) injury remains unclear. Therefore, the aim of the present study was to explore the neuroprotective effects of PN against oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells and the underlying mechanisms. Our results demonstrated that PN ameliorated OGD/R-evoked neuronal injury and oxidative stress in PC12 cells...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Soudeh Farzadfar, Fatemeh Zarinkamar, Mostafa Hojati
The accumulation of plant defense metabolites is closely associated with the concentration of nutrient elements, yet data related to the interactive effects of two nutrients on the deployment of phenolics and terpenoids are scare. In the present study, the interaction between magnesium (Mg) and manganese (Mn) on nutrient uptake, photosynthesis, oxidative status and the accumulation of phenolics and terpenoids in the leaves of feverfew plants grown at different concentrations of Mg and Mn was investigated. Nutrient uptake and photosynthesis were associated with the amount of applied Mg but could be modified by the concentration of Mn...
March 2017: Plant Physiology and Biochemistry: PPB
Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Equar Taka, Karam F A Soliman
Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, Parkinsons or Alzheimers disease. CNS inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (GBM). With growing public interest in complementary and alternative medicines (CAMs), we conduct a high throughput (HTP) screening of >1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lipopolysaccharide (LPS)/interferon gamma (IFNγ) activated C6 glioma cells...
January 15, 2017: Journal of Neuroimmunology
Elizabeth A Mazzio, Nan Li, David Bauer, Patricia Mendonca, Equar Taka, Mohammed Darb, Leeshawn Thomas, Henry Williams, Karam F A Soliman
BACKGROUND: Acute systemic inflammatory response syndrome arising from infection can lead to multiple organ failure and death, with greater susceptibility occurring in immunocompromised individuals. Moreover, sub-acute chronic inflammation is a contributor to the pathology of diverse degenerative diseases (Parkinson's disease, Alzheimer's disease and arthritis). Given the known limitations in Western medicine to treat a broad range of inflammatory related illness as well as the emergence of antibiotic resistance, there is a renewed interest in complementary and alternative medicines (CAMs) to achieve these means...
November 15, 2016: BMC Complementary and Alternative Medicine
Z Arıkan-Ayyıldız, M Karaman, S Özbal, A Bağrıyanık, O Yilmaz, Ö Karaman, N Uzuner
BACKGROUND: Parthenolide is the active constituent of the plant 'Tanacetum parthenium' (Feverfew) which has been used for centuries as a folk remedy for inflammatory conditions. AIM OF THE STUDY: In this study we aimed to investigate the effects of parthenolide in a murine model of chronic asthma. MATERIALS AND METHODS: Thirty-five BALB/c mice were divided into five groups; I (control), II (placebo), III (dexamethasone), IV (parthenolide) and V (dexamethasone and parthenolide combination)...
January 2017: Allergologia et Immunopathologia
Brian A Kahn, Eric J Rebek, Lynn P Brandenberger, Keith Reed, Mark E Payton
BACKGROUND: The squash bug, Anasa tristis (De Geer), is a major insect pest of cucurbits. Control of squash bugs with insecticidal chemicals is difficult to achieve. We investigated the potential of companion planting with white yarrow (Achillea millefolium L.) or feverfew [Tanacetum parthenium (L.) Sch. Bip.] for squash bug management in field plantings of summer squash (Cucurbita pepo L.). RESULTS: Companion planting with white yarrow had few effects. Companion planting with feverfew tended to reduce squash bug populations, but results often were not statistically significant (P ≥ 0...
June 2017: Pest Management Science
Soudeh Farzadfar, Fatemeh Zarinkamar, Mehrdad Behmanesh, Mostafa Hojati
A balanced nutrient supply is a critical factor affecting accumulation of terpenoids in plants, yet data related to the interactive effects of two essential nutrients for the biosynthesis of sesquiterpenes are scarce. Here, the interactional effects between magnesium (Mg) and manganese (Mn) on plant growth, oxidative status, parthenolide accumulation and expression of key genes involved in parthenolide biosynthesis including 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR), 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGR), germacrene A synthase (GAS), germacrene A oxidase (GAO), costunolide synthase (COS) and parthenolide synthase (PTS) in the leaves of feverfew plants grown at different Mn and Mn levels were assessed...
September 1, 2016: Journal of Plant Physiology
Krisztina Végh, Eszter Riethmüller, Anita Tóth, Ágnes Alberti, Szabolcs Béni, József Balla, Ágnes Kéry
Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache and rheumatoid arthritis and possesses numerous pharmacological activities. An ultra-high-performance supercritical fluid chromatographic method (UHPSFC) was developed and validated in accordance with the International Conference on Harmonization guidelines in order to determine the camphor content of the volatile oil, which was accurate, precise, robust and selective...
December 2016: Biomedical Chromatography: BMC
Tien-Yao Tsai, Shyh-Liang Lou, Ka-Shun Cheng, Kar-Lok Wong, Mei-Ling Wang, Tzu-Hui Su, Paul Chan, Yuk-Man Leung
Parthenolide is a sesquiterpene lactone compound isolated from the leaves and flowerheads of the plant feverfew (Tanacetum parthenium). The anticancer effects of parthenolide have been well studied and this lactone compound is currently under clinical trials. Parthenolide is also a protective agent in cardiac reperfusion injury via its inhibition of nuclear factor-κB (NF-κB). Not much is known if this compound affects signal transduction in non-tumor cells. We investigated whether parthenolide affected Ca(2+) signaling in endothelial cells, key components in regulating the vascular tone...
December 15, 2015: European Journal of Pharmacology
Mohammad Majdi, Mohammad Reza Abdollahi, Asad Maroufi
Up-regulation of germacrene A synthase and down-regulation of parthenolide hydroxylase genes play key role in parthenolide accumulation of feverfew plants treated with methyl jasmonate and salicylic acid. Parthenolide is an important sesquiterpene lactone due to its anti-migraine and anti-cancer properties. Parthenolide amount was quantified by high-performance liquid chromatography after foliar application of methyl jasmonate (100 µM) or salicylic acid (1.0 mM) on feverfew leaves in time course experiment (3-96 h)...
November 2015: Plant Cell Reports
Lorenzo Di Cesare Mannelli, Barbara Tenci, Matteo Zanardelli, Anna Maidecchi, Andrea Lugli, Luisa Mattoli, Carla Ghelardini
BACKGROUND: Tanacetum parthenium L., commonly called Feverfew, is known for anti-inflammatory and anti-migraine properties. PURPOSE: Aimed to individuate new therapeutical strategies to control acute and persistent pain induced by different origins we tested two hydroalcoholic extracts obtained from Feverfew flowers and leaves, respectively. STUDY DESIGN: Extracts were characterized according to the European Pharmacopoeia monograph. Both the extracts were tested after acute per os administration in the dose range 30-1000 mg kg(-1)...
July 15, 2015: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Kenneth J Clemetson
Stan Heptinstall's contributions to platelet research covered organising meetings at the national and European level as well as starting and maintaining the journal "Platelets". The major part of his research addressed problems of inhibition of platelet receptors and the effects of this on patient health. In particular, the effects of P2Y12 inhibitors on patients with acute cardiovascular problems were a major focus. Other studies included the effects of feverfew (Tanacetum parthenium) extracts on platelets, of direct anti-IIb/IIIa receptor (αIIbβ3) inhibitors and of prostanoids on platelet function...
2015: Platelets
Elzbieta Studzińska-Sroka, Paulina Znajdek-Awizeń, Anna Gawron-Gzella
Feverfew was already known at the beginning of our era. In folk medicine, infusions from the leaves of Tanacetum parthenium were used in rheumatism, fever, and in migraine, menstrual pain, toothaches also digestive troubles, cough, or parasitic diseases. It has been proved that the biological activity of the plants resultsfrom the presence of the chemical compounds with different structures, including the the sesquiterpene lactones, which include partenolid, determining the antimigraine properties of plants...
2013: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Snezana Agatonovic-Kustrin, Davoud Babazadeh Ortakand, David W Morton, Ahmad P Yusof
The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical as a post-chromatographic derivatization agent to compare the free radical scavenging activities of these components in leaf and flower head extracts from feverfew, German chamomile and marigold from the Asteraceae family. Feverfew (Tanacetum parthenium) leaves have been traditionally used in the treatment of migraine with parthenolide being the main bioactive compound...
March 13, 2015: Journal of Chromatography. A
Qing Liu, David Manzano, Nikola Tanić, Milica Pesic, Jasna Bankovic, Irini Pateraki, Lea Ricard, Albert Ferrer, Ric de Vos, Sander van de Krol, Harro Bouwmeester
Parthenolide, the main bioactive compound of the medicinal plant feverfew (Tanacetum parthenium), is a promising anti-cancer drug. However, the biosynthetic pathway of parthenolide has not been elucidated yet. Here we report on the isolation and characterization of all the genes from feverfew that are required for the biosynthesis of parthenolide, using a combination of 454 sequencing of a feverfew glandular trichome cDNA library, co-expression analysis and metabolomics. When parthenolide biosynthesis was reconstituted by transient co-expression of all pathway genes in Nicotiana benthamiana, up to 1...
May 2014: Metabolic Engineering
K Linde
Complementary therapies are widely used and play an important role in the treatment of chronic pain syndromes. This review summarizes the evidences from randomized controlled trials for the effectiveness of a number of complementary therapies in migraine prophylaxis. The largest number of studies (a total of 15) is available for acupuncture. These studies are very heterogeneous in respect to interventions, methodological quality and outcome measurement, and the results are partly contradictory. The majority of trials, however, suggests that acupuncture is effective in migraine prophylaxis...
May 2002: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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