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Breast reduction tranexamic acid

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https://www.readbyqxmd.com/read/26967076/the-efficacy-and-safety-of-tranexamic-acid-in-cranio-maxillofacial-and-plastic-surgery
#1
George Richard Francis Murphy, Graeme Ewan Glass, Abhilash Jain
The antifibrinolytic drug tranexamic acid (TXA) is effective in reducing blood loss and transfusion requirements in other fields of elective surgery and its use is emerging in a number of plastic surgical subspecialties. This systematic review and meta-analysis evaluates the current evidence for the efficacy and safety of TXA in craniomaxillofacial, head and neck, breast, aesthetic, burns, and reconstructive microsurgery. We searched PubMed, EMBASE, Medline, The Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials for randomized controlled trials of TXA in plastic surgery...
March 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/21701432/pharmacological-therapy-for-abnormal-uterine-bleeding
#2
REVIEW
JoAnn V Pinkerton
Pharmacological therapies for the treatment of abnormal uterine bleeding are effective and generally well tolerated. This review presents an evidence-based approach to medical therapy. Selection depends on the etiology and amount of bleeding, need for contraception or preservation of fertility, perimenopause status, and medication efficacy and adverse effects.Available nonhormonal agents include nonsteroidal anti-inflammatory agents, which reduce bleeding by 25% to 35% and improve dysmenorrhea through reduced prostaglandin levels; tranexamic acid, which inhibits plasminogen activator with a 40% to 60% reduction in menstrual blood loss; and intranasal desmopressin, which is an antifibrinolytic for women with an underlying bleeding disorder (eg, von Willebrand disease)...
April 2011: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/20398351/the-woman-trial-world-maternal-antifibrinolytic-trial-tranexamic-acid-for-the-treatment-of-postpartum-haemorrhage-an-international-randomised-double-blind-placebo-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Haleema Shakur, Diana Elbourne, Metin G├╝lmezoglu, Zarko Alfirevic, Carine Ronsmans, Elizabeth Allen, Ian Roberts
BACKGROUND: Each year, worldwide about 530,000 women die from causes related to pregnancy and childbirth. Of the deaths 99% are in low and middle income countries. Obstetric haemorrhage is the leading cause of maternal mortality, most occurring in the postpartum period. Systemic antifibrinolytic agents are widely used in surgery to prevent clot breakdown (fibrinolysis) in order to reduce surgical blood loss. At present there is little reliable evidence from randomised trials on the effectiveness of tranexamic acid in the treatment of postpartum haemorrhage...
2010: Trials
https://www.readbyqxmd.com/read/18253983/cyclical-progestogens-for-heavy-menstrual-bleeding
#4
REVIEW
A Lethaby, G Irvine, I Cameron
BACKGROUND: Excessively heavy menstrual bleeding (HMB) or menorrhagia is an important cause of ill health in women. Eighty per cent of women treated for HMB have no anatomical pathology, which makes medical therapy, with the avoidance of possibly unnecessary surgery, an attractive alternative. Of the wide variety of medications used to reduce heavy menstrual bleeding, oral progestogens are the most commonly prescribed. This review assesses the effectiveness of two different regimens of oral progestogens in reducing ovulatory HMB...
2008: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/10796587/cyclical-progestogens-for-heavy-menstrual-bleeding
#5
REVIEW
A Lethaby, G Irvine, I Cameron
BACKGROUND: Excessively heavy menstrual bleeding (HMB) or menorrhagia is an important cause of ill health in women. Eighty per cent of women treated for HMB have no anatomical pathology and so medical therapy, with the avoidance of possibly unnecessary surgery, is an attractive alternative. Of the wide variety of medications used to reduce heavy menstrual bleeding, oral progestogens are the most commonly prescribed in many western countries, although there is little objective evidence to support their use, especially in women with ovulatory menstruation...
2000: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/9083329/proteinase-inhibitors-reduce-basement-membrane-degradation-by-human-breast-cancer-cell-lines
#6
P S Stonelake, C E Jones, J P Neoptolemos, P R Baker
The relative importance of different proteinases, and their inhibition, in the breakdown of human endothelial basement membrane (BM) by MDA-MB-231 and MCF7ADR human breast cancer cell lines has been studied using 35S-labelled BM-coated 96-well culture plates. Basement membrane degradation (BMD) was independent of cell proliferation above the seeding density. Inhibitors of aspartic (pepstatin and PD 134678-0073) and cysteine proteinases (E64) had little effect on BMD under normal culture conditions, suggesting that cathepsins D, B and L have only a minor role...
1997: British Journal of Cancer
https://www.readbyqxmd.com/read/8044602/perioperative-and-postoperative-tranexamic-acid-reduces-the-local-wound-complication-rate-after-surgery-for-breast-cancer
#7
RANDOMIZED CONTROLLED TRIAL
D Oertli, U Laffer, F Haberthuer, U Kreuter, F Harder
A randomized double-blind trial has shown that, in 160 women with breast cancer undergoing lumpectomy or mastectomy with axillary clearance, perioperative and postoperative administration of tranexamic acid 1 g three times daily resulted in a significant reduction in the mean postoperative drainage volume compared with patients given placebo (283 versus 432 ml, P < 0.001). The frequency of postoperative seroma formation was also decreased by tranexamic acid administration (27 versus 37 per cent, P = 0.2)...
June 1994: British Journal of Surgery
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