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Nerve graft

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https://www.readbyqxmd.com/read/29353106/perineurium-like-sheath-derived-from-long-term-surviving-mesenchymal-stem-cells-confers-nerve-protection-to-the-injured-spinal-cord
#1
Yuan-Huan Ma, Xiang Zeng, Xue-Cheng Qiu, Qing-Shuai Wei, Ming-Tian Che, Ying Ding, Zhou Liu, Guo-Hui Wu, Jia-Hui Sun, Mao Pang, Li-Min Rong, Bin Liu, Zaid Aljuboori, Inbo Han, Eng-Ang Ling, Yuan-Shan Zeng
The functional multipotency enables mesenchymal stem cells (MSCs) promising translational potentials in treating spinal cord injury (SCI). Yet the fate of MSCs grafted into the injured spinal cord has not been fully elucidated even in preclinical studies, rendering concerns of their safety and genuine efficacy. Here we used a rat spinal cord transection model to evaluate the cell fate of allograft bone marrow derived MSCs. With the application of immunosuppressant, donor cells, delivered by biocompatible scaffold, survived up to 8 weeks post-grafting...
January 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29343900/direct-electrical-injury-to-brachial-plexus
#2
Maksud Mubarak Devale, Gaurav Jatin Kadakia, Vicky Ghewarchand Jain, Rohit Prakash Munot
Electrical current can cause neurological damage directly or by conversion to thermal energy. However, electrical injury causing isolated brachial plexus injury without cutaneous burns is extremely rare. We present a case of a 17-year-old boy who sustained accidental electrical injury to left upper extremity with no associated entry or exit wounds. Complete motor and sensory loss in upper limb were noted immediately after injury. Subsequently, the patient showed partial recovery in muscles around the shoulder and in ulnar nerve distribution at 6 months...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29339841/role-of-autologous-non-vascularised-intramedullary-fibular-strut-graft-in-humeral-shaft-nonunions-following-failed-plating
#3
Sreekanth Kashayi-Chowdojirao, Aashish Vallurupalli, Vijay Krishna Chilakamarri, Chandrasekhar Patnala, Lalith Mohan Chodavarapu, Nageswara Rao Kancherla, Asif Hussain Khazi Syed
Background: Non-union humeral shaft fractures are seen frequently in clinical practice at about 2-10% in conservative management and 30% in surgically operated patients. Osteosynthesis using dynamic compression plate (DCP), intramedullary nailing, locking compression plate (LCP), Ilizarov technique along with bone grafting have been reported previously. In cases of prior failed plate-screw osteosynthesis the resultant osteopenia, cortical defect, bone loss, scalloping around screws and metallosis, make the management of non-union more complicated...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29336177/in-vivo-assessment-of-a-nanofibrous-silk-tube-as-nerve-guide-for-sciatic-nerve-regeneration
#4
Maryam Ebrahimi, Jafar Ai, Esmaeil Biazar, Somayeh Ebrahimi-Barough, Arash Khojasteh, Meysam Yazdankhah, Siavash Sharifi, Arman Ai, Saeed Heidari-Keshel
A nanofibrous silk nerve conduit has been evaluated for its efficiency based on the promotion of peripheral nerve regeneration in rats. The designed tubes with or without Schwann cells were implanted into a 10 mm gap in the sciatic nerves of the rats. Four months after the surgery, the regenerated nerves were monitored and evaluated by macroscopic assessments and histology. The results demonstrated that the nanofibrous grafts, especially in the presence of Schwann cells, enabled reconstruction of the rat sciatic nerve trunk with a restoration of nerve continuity and formation of nerve fibres with myelination...
January 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29332226/monocortical-fixation-of-the-coracoid-in-the-latarjet-procedure-is-significantly-weaker-than-bicortical-fixation
#5
Uli Schmiddem, Nael Hawi, Emmanouil Liodakis, Antonios Dratzidis, Manuel Kraemer, Christof Hurschler, Richard Page, Rupert Meller
PURPOSE: A crucial step of the Latarjet procedure is the fixation of the coracoid process onto the glenoid. Multiple problems associated with the fixation have been described, including lesions of the suprascapular nerve due to prominence of the screw or bicortical drilling. The purpose of the present study was to evaluate whether monocortical fixation, without perforating the posterior glenoid cortex, would provide sufficient graft stability. METHODS: Coracoid transfer was performed in 14 scapula models (Sawbones®, Composite Scapula, 4th generation)...
January 13, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29330037/sustained-delivery-of-glial-cell-derived-neurotrophic-factors-in-collagen-conduits-for-facial-nerve-regeneration
#6
Fukai Ma, Feng Xu, Ronggang Li, Yongtao Zheng, Fan Wang, Naili Wei, Junjie Zhong, Qisheng Tang, Tongming Zhu, Zhifu Wang, Jianhong Zhu
Facial nerve injury caused by traffic accidents or operations may reduce the quality of life in patients, and recovery following the injury presents unique clinical challenges. Glial cell-derived neurotrophic factor (GDNF) is important in nerve regeneration; however, soluble GDNF rapidly diffuses into body fluids, making it difficult to achieve therapeutic efficacy. In this work, we developed a rat tail derived collagen conduit to connect nerve defects in a simple and safe manner. GDNF was immobilized in the collagen conduits via chemical conjugation to enable controlled release of GDNF...
January 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29327452/regenerative-effects-of-human-embryonic-stem-cell-derived-neural-crest-cells-for-treatment-of-peripheral-nerve-injury
#7
Iwan Jones, Liudmila N Novikova, Lev N Novikov, Monika Renardy, Andreas Ullrich, Mikael Wiberg, Leif Carlsson, Paul J Kingham
Surgical intervention is the current gold standard treatment following peripheral nerve injury. However, this approach has limitations and full recovery of both motor and sensory modalities often remains incomplete. The development of artificial nerve grafts that either complement or replace current surgical procedures is therefore of paramount importance. An essential component of artificial grafts are biodegradable conduits and transplanted cells that provide trophic support during the regenerative process...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29323049/autologous-transplantation-with-fewer-fibers-repairs-large-peripheral-nerve-defects
#8
Jiu-Xu Deng, Dian-Yin Zhang, Ming Li, Jian Weng, Yu-Hui Kou, Pei-Xun Zhang, Na Han, Bo Chen, Xiao-Feng Yin, Bao-Guo Jiang
Peripheral nerve injury is a serious disease and its repair is challenging. A cable-style autologous graft is the gold standard for repairing long peripheral nerve defects; however, ensuring that the minimum number of transplanted nerve attains maximum therapeutic effect remains poorly understood. In this study, a rat model of common peroneal nerve defect was established by resecting a 10-mm long right common peroneal nerve. Rats receiving transplantation of the common peroneal nerve in situ were designated as the in situ graft group...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29315828/a-collagen-coated-pga-conduit-for-interpositional-jump-graft-with-end-to-side-neurorrhaphy-for-treating-facial-nerve-paralysis-in-rat
#9
Yosuke Niimi, Hajime Matsumine, Yuichi Takeuchi, Hironobu Osaki, Satoshi Tsunoda, Mariko Miyata, Masayuki Yamato, Hiroyuki Sakurai
PURPOSE: This study investigated the potential of collagen-coated polyglycolic acid (PGA) tube with interpositional jump graft (IPJG) in rat. MATERIALS AND METHODS: A total of 16 Lewis rats were used in this study. Facial nerve paralysis was created by ligating facial nerve trunk with a ligature clip. The rats were divided into 3 groups. Nerve conduit group (n = 6) were treated by IPJG with collagen-coated PGA tubes between the facial nerve trunks and the hypoglossal nerves...
January 8, 2018: Microsurgery
https://www.readbyqxmd.com/read/29311017/reanimation-of-the-paralyzed-lids-by-cross-face-nerve-graft-and-platysma-transfer
#10
Federico Biglioli, Matteo Zago, Fabiana Allevi, Daniela Ciprandi, Giovanni Dell'Aversana Orabona, Valentina Pucciarelli, Dimitri Rabbiosi, Ilaria Pacifici, Filippo Tarabbia, Chiarella Sforza
Alterations of facial muscles may critically humper patients' quality of life. One of the worst conditions is the reduction or abolition of eye blinking. To prevent these adverse effects, surgical rehabilitation of eyelid function is the current treatment choice. In the present paper, we present a modification of the technique devised by Nassif to recover lids from long-standing paralysis. In our modification, the upper lid is rehabilitated by a platisma graft innervated by the contralateral facial nerve branches using a cross-face sural nerve graft...
December 27, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29305252/the-anatomy-of-the-sacral-promontory-how-to-avoid-complications-of-the-sacrocolpopexy-procedure
#11
Géraldine Giraudet, Aurore Protat, Michel Cosson
Because of problems with vaginal meshes and high rate recurrences of native tissue repair, more and more surgeons treat pelvic organ prolapse performing laparoscopic sacrocolpopexy. This surgery requires skilled surgeons. The first step of sacrocolpopexy is the dissection of tissues in front of the sacral promontory to reach the anterior longitudinal ligament. Some complications can occur during this dissection and the attachment of the mesh. This place is dangerous for surgeons because of the proximity of vessels, nerves and ureters...
January 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29302142/simplified-cable-nerve-grafting-with-nerve-cutting-guides-and-fibrin-glue
#12
Reid W Draeger, Donald K Bynum, J Megan M Patterson
Cable nerve grafting is the recommended surgical treatment for large peripheral nerve defects. Traditionally, this is performed by bridging a gap in the nerve with multiple autologous nerve cables, repairing the epineurium of each cable to the perineurium of a fascicle of the injured nerve that is similar in size to the graft. The authors present a new technique in which they used nerve-cutting guides to aid in the placement of fibrin glue to secure the sides of the cabled nerve graft together to facilitate handling of the cabled nerve graft and to expedite repair...
December 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29295654/integration-of-transplanted-neural-precursors-with-the-injured-spinal-cord
#13
Victoria Marie Spruance, Lyandysha Viktorovna Zholudeva, Kristiina M Hormigo, Margo L Randelman, Tatiana Bezdudnaya, Vitaliy Marchenko, Michael A Lane
Cervical spinal cord injuries (SCI) result in devastating functional consequences, including respiratory dysfunction. This is largely due to the disruption of phrenic pathways, which control the diaphragm. Recent work has identified spinal interneurons as possible contributors to respiratory neuroplasticity. The present work investigated whether transplantation of developing spinal cord tissue, inherently rich in interneuronal progenitors, could provide a population of new neurons and growth permissive substrate to facilitate plasticity and formation of novel relay circuits to restore input to the partially denervated phrenic motor circuit...
January 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29291297/surgical-repair-of-sciatic-nerve-traumatic-rupture-technical-considerations-and-approaches
#14
Hussam Abou-Al-Shaar, Nam Yoon, Mark A Mahan
Traumatic proximal sciatic nerve rupture poses surgical repair dilemmas. Disruption often causes a large nerve gap after proximal neuroma and distal scar removal. Also, autologous graft material to bridge the segmental defect may be insufficient, given the sciatic nerve diameter. The authors utilized knee flexion to allow single neurorrhaphy repair of a large sciatic nerve defect, bringing healthy proximal stump to healthy distal segment. To avoid aberrant regeneration, the authors split the sciatic nerve into common peroneal and tibial divisions...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29291295/radial-to-axillary-nerve-transfer
#15
Vicente Vanaclocha, Juan Manuel Herrera, Marlon Rivera-Paz, Deborah Martínez-Gómez, Leyre Vanaclocha
Axillary nerve injury is common after brachial plexus injuries, particularly with shoulder luxation. Nerve grafting is the traditional procedure for postganglionic injuries. Nerve transfer is emerging as a viable option particularly in late referrals. At the proximal arm the radial and axillary nerves lie close by. Sacrificing one of the triceps muscle nerve branches induces little negative consequences. Transferring the long head of the triceps nerve branch is a good option to recover axillary nerve function...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29290136/a-novel-noninstrumented-surgical-approach-for-foramen-reconstruction-for-isthmic-spondylolisthesis-in-patients-with-radiculopathy-preliminary-clinical-and-radiographic-outcomes
#16
Jochem K H Spoor, Alof H G Dallenga, Pravesh S Gadjradj, Luuk de Klerk, Frans C van Biezen, Henk W C Bijvoet, Biswadjiet S Harhangi
OBJECTIVE The health care costs for instrumented spine surgery have increased dramatically in the last few decades. The authors present a novel noninstrumented surgical approach for patients with isthmic spondylolisthesis, with clinical and radiographic results. METHODS Charts of patients who underwent this technique were reviewed. The procedure consisted of nerve root decompression by reconstruction of the intervertebral foramen. This was achieved by removal of the pedicle followed by noninstrumented posterolateral fusion in which autologous bone graft from the right iliac crest was used...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29288689/skin-derived-precursor-schwann-cell-generated-acellular-matrix-modified-chitosan-silk-scaffolds-for-bridging-rat-sciatic-nerve-gap
#17
Changlai Zhu, Jing Huang, Chengbin Xue, Yaxian Wang, Shengran Wang, Shuangxi Bao, Ruyue Chen, Yuan Li, Yun Gu
Extracellular/acellular matrix has been attracted much research interests for its unique biological characteristics, and ACM modified neural scaffolds shows the remarkable role of promoting peripheral nerve regeneration. In this study, skin-derived precursors pre-differentiated into Schwann cells (SKP-SCs) were used as parent cells to generate acellular(ACM) for constructing a ACM-modified neural scaffold. SKP-SCs were co-cultured with chitosan nerve guidance conduits (NGC) and silk fibroin filamentous fillers, followed by decellularization to stimulate ACM deposition...
December 27, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29286436/stromal-vascular-fraction-enriched-fat-grafting-for-the-treatment-of-symptomatic-end-neuromata
#18
Simon Zimmermann, Richard M Fakin, Thomas Giesen, Pietro Giovanoli, Maurizio Calcagni
The purpose of this study was to methodically illustrate and highlight the crucial steps of stromal vascular fraction (SVF)-enriched fat grafting as a novel treatment of symptomatic end-neuromata of peripheral sensory nerves, and in this study, specifically of the superficial branch of the radial nerve (SBRN). Despite a multitude of existing treatments, persistent postoperative pain and common pain relapse are still very common, independent of the procedure assessed. The neuroma is microsurgically excised accordingly to standardized protocol...
November 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29283938/immediate-hypoglossal-facial-anastomosis-in-patients-with-facial-interruption
#19
Sertac Yetiser
Hypoglossal-facial anastomosis provides excellent motor supply to the mimetic muscles of the face when there is no chance of recovery of the damaged facial nerve. However, to achieve optimal results, the timing of facial nerve surgery based on electrophysiological testing and clinical evaluation requires close follow-up of the patient. Functional results after delayed surgery are not predictable and depend on the number of surviving fibers, type of injury, severity of damage, degree of infiltration of inflammatory cells, and local fibrosis...
December 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29282488/outcome-of-surgery-for-nerve-injury-following-total-hip-arthroplasty
#20
James W Pritchett
PURPOSE: During hip replacement, nerves in the operative field can be injured accidently. Additional surgical procedures can help restore function and reduce pain if there has been no recovery. METHODS: One-hundred sixty-two patients presented with nerve injuries, and 113 were candidates for surgical treatment. The author performed 91 procedures on the injured limb (80 patients; 11 had 2 procedures) consisting of shortening, sympathectomy, tendon transfer, neurolysis or nerve repair/graft and 30 spinal and three fibular-neck decompressions...
December 28, 2017: International Orthopaedics
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