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https://www.readbyqxmd.com/read/29162694/an-endogenous-retroviral-envelope-syncytin-and-its-cognate-receptor-identified-in-the-viviparous-placental-mabuya-lizard
#1
Guillaume Cornelis, Mathis Funk, Cécile Vernochet, Francisca Leal, Oscar Alejandro Tarazona, Guillaume Meurice, Odile Heidmann, Anne Dupressoir, Aurélien Miralles, Martha Patricia Ramirez-Pinilla, Thierry Heidmann
Syncytins are envelope genes from endogenous retroviruses that have been captured during evolution for a function in placentation. They have been found in all placental mammals in which they have been searched, including marsupials. Placental structures are not restricted to mammals but also emerged in some other vertebrates, most frequently in lizards, such as the viviparous Mabuya Scincidae. Here, we performed high-throughput RNA sequencing of a Mabuya placenta transcriptome and screened for the presence of retroviral env genes with a full-length ORF...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29149581/family-matters-measuring-impact-through-one-s-academic-descendants
#2
Elizabeth J Marsh
Scientific contributions take many forms, not all of which result in fame or are captured in traditional metrics of success (e.g., h factor). My focus is on one of the most lasting and important contributions a scientist can make: training scientists who go on to train scientists, who in turn train more scientists, etc. Academic genealogies provide many examples of scientists whose names might not be recognizable today but who trained psychologists that went on to publish very influential work. Of course success results from a combination of many factors (including but not limited to the student's abilities and motivation, luck, institutional resources, mentoring, etc...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149165/-reflections-on-the-death-of-my-father
#3
Domenico Ribatti
This short essay aims to provide the reader with some general considerations from a private matter, namely the death of the author's father after a long and disabling neurodegenerative disease. The author's reflection revolves around the meaning of death, the relationship between children and parents, the importance of individual and collective memory, and the role that physicians should have in dealing with relatives of subjects suffering from this type of disease.
November 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29118960/from-the-padua-muscle-days-the-basic-and-applied-myology-and-the-european-journal-of-translational-myology-to-the-a-cm-carraro-foundation-for-translational-myology
#4
Ugo Carraro
As a young researched I had the option to work on skeletal muscle at the University of Padova, Italy. Introduced to the study of muscle denervation/reinnervation, I started a project on long term denervated muscle that still is my primary interest and took me from rodents' models of chronic muscle denervation to human spinal cord injury-related muscle denervation and its managements. On the way, I organized a series of conferences in Euganei Hills, Padua, Italy and an international journal, the Basic and Applied Myology...
June 27, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29111537/synthesis-structure-and-in-vitro-cytotoxicity-of-platinum-ii-complexes-containing-eugenol-and-a-quinolin-8-ol-derived-chelator
#5
Chi Nguyen Thi Thanh, Mai Truong Thi Cam, Thong Pham Van, Long Nguyen, My Nguyen Ha, Luc Van Meervelt
The synthesis of potassium (η(2)-4-allyl-2-methoxyphenol)trichloridoplatinate(II), K[PtCl3(C10H12O2)], (1), starting from Zeise's salt and Ocimum sanctum L. oil has been optimized. Starting from (1), three new platinum(II) complexes, namely (η(2)-4-allyl-2-methoxyphenol)chlorido(2-methylquinolin-8-olato-κ(2)N,O)platinum(II), (2), (η(2)-4-allyl-2-methoxyphenol)chlorido(5-nitroquinolin-8-olato-κ(2)N,O)platinum(II), (3), and (η(2)-4-allyl-2-methoxyphenol)chlorido(5,7-dichloroquinolin-8-olato-κ(2)N,O)platinum(II), [Pt(C9H4Cl2NO)Cl(C10H12O2)], (4), containing eugenol and a quinolin-8-ol derivative (R-OQ), have been synthesized and characterized by elemental analyses, MS, IR, (1)H NMR and NOESY spectra...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29043045/radseq-dataset-with-90-missing-data-fully-resolves-recent-radiation-of-petalidium-acanthaceae-in-the-ultra-arid-deserts-of-namibia
#6
Erin A Tripp, Yi-Hsin Erica Tsai, Yongbin Zhuang, Kyle G Dexter
Deserts, even those at tropical latitudes, often have strikingly low levels of plant diversity, particularly within genera. One remarkable exception to this pattern is the genus Petalidium (Acanthaceae), in which 37 of 40 named species occupy one of the driest environments on Earth, the Namib Desert of Namibia and neighboring Angola. To contribute to understanding this enigmatic diversity, we generated RADseq data for 47 accessions of Petalidium representing 22 species. We explored the impacts of 18 different combinations of assembly parameters in de novo assembly of the data across nine levels of missing data plus a best practice assembly using a reference Acanthaceae genome for a total of 171 sequence datasets assembled...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29021836/specific-protein-biomarker-patterns-for-alzheimer-s-disease-improved-diagnostics-in-progress
#7
REVIEW
Illana Gozes
This short review looks at Alzheimer's disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer's diagnosis. In one paper, we took an approach of selecting a specific target, namely, activity-dependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expression of the regulator of G-protein signaling 2 (RGS2) as a potential AD predictor...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/28981967/lessons-from-a-lost-world-messages-from-the-mental-hospital-era
#8
EDITORIAL
Niall McCrae
Pertinent questions, you might think. Yet in my experience, as a nurse educator and extracurricular historian of mental health nursing, they are not readily answerable by qualified or budding practitioners. The first would expose a remarkable lack of celebrated figures in our field. General nursing has its heroine in Florence Nightingale, but asking students to name pioneers of psychiatric nursing draws a blank stare. The second question relates to the transformation from institutional to community-based care...
October 5, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28981697/multiple-modes-of-positive-selection-shaping-the-patterns-of-incomplete-selective-sweeps-over-african-populations-of-drosophila-melanogaster
#9
Ha My T Vy, Yong-Jin Won, Yuseob Kim
It remains a challenge in evolutionary genetics to elucidate how beneficial mutations arise and propagate in a population and how selective pressures on mutant alleles are structured over space and time. By identifying "sweeping haplotypes (SHs)" that putatively carry beneficial alleles and are increasing (or have increased) rapidly in frequency, and surveying the geographic distribution of SH frequencies, we can indirectly infer how selective sweeps unfold in time and thus which modes of positive selection underlie those sweeps...
November 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28948041/characterization-of-posa-and-posa-like-virus-genomes-in-fecal-samples-from-humans-pigs-rats-and-bats-collected-from-a-single-location-in-vietnam
#10
Bas B Oude Munnink, My V T Phan, Peter Simmonds, Marion P G Koopmans, Paul Kellam, Lia van der Hoek, Matthew Cotten
Porcine stool-associated RNA virus (posavirus), and Human stool-associated RNA virus (husavirus) are viruses in the order Picornavirales recently described in porcine and human fecal samples. The tentative group (Posa and Posa-like viruses: PPLVs) also includes fish stool-associated RNA virus (fisavirus) as well as members detected in insects (Drosophila subobscura and Anopheles sinensis) and parasites (Ascaris suum). As part of an agnostic deep sequencing survey of animal and human viruses in Vietnam, we detected three husaviruses in human fecal samples, two of which share 97-98% amino acid identity to Dutch husavirus strains and one highly divergent husavirus with only 25% amino acid identity to known husaviruses...
July 2017: Virus Evolution
https://www.readbyqxmd.com/read/28891342/towards-a-critical-health-equity-research-stance-why-epistemology-and-methodology-matter-more-than-qualitative-methods
#11
Lisa Bowleg
Qualitative methods are not intrinsically progressive. Methods are simply tools to conduct research. Epistemology, the justification of knowledge, shapes methodology and methods, and thus is a vital starting point for a critical health equity research stance, regardless of whether the methods are qualitative, quantitative, or mixed. In line with this premise, I address four themes in this commentary. First, I criticize the ubiquitous and uncritical use of the term health disparities in U.S. public health. Next, I advocate for the increased use of qualitative methodologies-namely, photovoice and critical ethnography-that, pursuant to critical approaches, prioritize dismantling social-structural inequities as a prerequisite to health equity...
September 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28886750/evidence-based-gene-models-for-structural-and-functional-annotations-of-the-oil-palm-genome
#12
Kuang-Lim Chan, Tatiana V Tatarinova, Rozana Rosli, Nadzirah Amiruddin, Norazah Azizi, Mohd Amin Ab Halim, Nik Shazana Nik Mohd Sanusi, Nagappan Jayanthi, Petr Ponomarenko, Martin Triska, Victor Solovyev, Mohd Firdaus-Raih, Ravigadevi Sambanthamurthi, Denis Murphy, Eng-Ti Leslie Low
BACKGROUND: Oil palm is an important source of edible oil. The importance of the crop, as well as its long breeding cycle (10-12 years) has led to the sequencing of its genome in 2013 to pave the way for genomics-guided breeding. Nevertheless, the first set of gene predictions, although useful, had many fragmented genes. Classification and characterization of genes associated with traits of interest, such as those for fatty acid biosynthesis and disease resistance, were also limited...
September 8, 2017: Biology Direct
https://www.readbyqxmd.com/read/28862142/cancer-screening-for-older-people-to-screen-or-not-to-screen
#13
REVIEW
C Ky Lai, A Igarashi, N My Lau, C Tk Yu
In this scoping review, the evidence of the benefits of screening older people for the five most common types of cancer in Hong Kong, namely colorectal, lung, breast, liver, and prostate cancers, is discussed. Although cancer treatments can be extensive and a good prognosis is less likely if cancer is diagnosed at a late stage, screening programmes for older people in primary care remain a matter of contention. The general recommendation for the screening of older people is to adopt an individualised approach that takes account of not only age but also co-morbidity, life expectancy, harms and benefits, and patient's preference...
October 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28839923/why-developmental-niche-construction-is-not-selective-niche-construction-and-why-it-matters
#14
Karola Stotz
In the last decade, niche construction has been heralded as the neglected process in evolution. But niche construction is just one way in which the organism's interaction with and construction of the environment can have potential evolutionary significance. The constructed environment does not just select for, it also produces new variation. Nearly 3 decades ago, and in parallel with Odling-Smee's article 'Niche-constructing phenotypes', West and King introduced the 'ontogenetic niche' to give the phenomena of exogenetic inheritance a formal name...
October 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28776482/procrastination-as-a-self-regulation-failure-the-role-of-impulsivity-and-intrusive-thoughts
#15
Marie My Lien Rebetez, Lucien Rochat, Catherine Barsics, Martial Van der Linden
Procrastination has been described as the quintessence of self-regulatory failure. This study examines the relationships between this self-regulatory failure and other manifestations of self-regulation problems, namely impulsivity and intrusive thoughts. One hundred and forty-one participants completed questionnaires assessing procrastination, impulsivity (in particular, the urgency and lack of perseverance dimensions), and intrusive thoughts (i.e., rumination and daydreaming). Main results show that urgency mediated the association between rumination and procrastination, whereas rumination did not mediate the relation between urgency and procrastination...
January 1, 2017: Psychological Reports
https://www.readbyqxmd.com/read/28766419/mental-health-nurse-helps-me-feel-empowered-and-independent
#16
(no author information available yet)
Nadine and I met during my first admission to the psychiatric ward at Dr Gray's Hospital, Elgin, Moray, in 2003. She was my named nurse at the time, and has been my community mental health nurse for the past three years.
August 2, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28736014/efficacy-and-safety-of-generic-mycophenolate-mofetil-my-rept-500-milligram-tablets-in-primary-liver-transplant-recipients
#17
S K Hong, K-W Lee, K C Yoon, H-S Kim, H Kim, N-J Yi, K-S Suh
BACKGROUND: Generic immunosuppressants may be cost-effective if clinical outcomes are equivalent to the brand-name medications. Mycophenolate mofetil in the form of My-rept may be cost-effective being a generic immunosuppressant, which is available as a 500-mg tablet as well as a 250-mg capsule (Chong Kun Dang Pharmaceutical Corporation, Seoul, Korea). OBJECTIVE: This study aimed to evaluate the efficacy, safety, cost-effectiveness, and convenience of My-rept 500-mg tablets in liver transplant recipients...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28609963/validation-of-the-replacement-name-i-eusceliotes-i-stebbing-1888-for-the-pelagic-hyperiidean-amphipod-genus-i-euscelus-i-claus-1879-crustacea-amphipoda-hyperiidea-parascelidae-preoccupied-by-i-euscelus-i-schoenherr-1833-insecta-coleoptera-attelabidae
#18
Wolfgang Zeidler
The generic name Euscelus was originally proposed by Schoenherr (1833: 205) for a genus of Leaf Rolling weevils (Insecta: Coleoptera: Attelabidae). It is a valid name, in current use, for a relatively large genus of weevils, widespread in northern South America and central America, including the West Indies and the Caribbean (e.g. Hamilton 2007; Legalov 2007). Euscelus Claus, 1879 was established as a monotypic genus of pelagic amphipod (Crustacea: Amphipoda: Hyperiidea: Parascelidae). It is a very rare genus, still monotypic, with the only species, E...
April 18, 2017: Zootaxa
https://www.readbyqxmd.com/read/28566662/practical-management-of-deep-cutaneous-fungal-infections
#19
REVIEW
Tomotaka Sato
Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28543653/ripples-what-to-expect-when-you-serve-on-a-bioethics-commission
#20
Thomas H Murray
Cloning was the issue that put the National Bioethics Advisory Commission on the map, but the first clue that NBAC would address cloning was a terse fax from the White House to each of us who served on the Commission. The fax noted that with the birth of the sheep named Dolly, mammalian cloning was now a reality, and it tasked NBAC with providing advice on the ethics of human cloning and how the nation should respond to it. We were given ninety days to report our findings. That's a very tight deadline for a report written by a committee, but we met it, and along the way, I learned important lessons...
May 2017: Hastings Center Report
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