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https://www.readbyqxmd.com/read/29332246/an-historical-perspective-of-the-discovery-of-titin-filaments-part-2
#1
REVIEW
Cristobal G Dos Remedios
In 2017, a Special Issue of Biophysical Reviews was devoted to "Titin and Its Binding Partners. The issue contained a review: "An historical perspective of the discovery of titin filaments" by dos Remedios and Gilmour that was intended to be a history of the discovery of the giant protein titin, previously named connectin. The review took readers back to the earliest discovery of the so-called third filament component of skeletal and cardiac muscle sarcomeres and ended in 1969. Recently, my colleague Shin'ichi Ishiwata gently reminded me of two papers published in 1990 and 1993 that were unwittingly omitted from the original historical perspective...
January 13, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29280271/paper-1-nursing-as-concrete-philosophy-part-i-risjord-on-nursing-knowledge
#2
Kyriakos Theodoridis
This essay addresses the problem of the essentiality of nursing knowledge and what kind of theory, if any, is essential to nursing practice. The overarching aim of the essay was to argue for the thesis that nursing may be described as a kind of philosophical activity, and, consequently, that philosophy is the kind of "theory" that is essential to nursing practice and to the nursing discipline at large. The essay consists of two papers. The present paper, Part I, is a critical examination of Mark Risjord's discussion of the problem of the theory-practice gap in his Nursing Knowledge: Practice, Science, Philosophy, from 2010...
December 26, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/29258480/end-of-life-care-preferences-among-people-of-advanced-age-lilacs-nz
#3
Merryn Gott, Rosemary Frey, Janine Wiles, Anna Rolleston, Ruth Teh, Tess Moeke-Maxwell, Ngaire Kerse
BACKGROUND: Understanding end of life preferences amongst the oldest old is crucial to informing appropriate palliative and end of life care internationally. However, little has been reported in the academic literature about the end of life preferences of people in advanced age, particularly the preferences of indigenous older people, including New Zealand Māori. METHODS: Data on end of life preferences were gathered from 147 Māori (aged >80 years) and 291 non- Māori aged (>85 years), during three waves of Te Puawaitangi O Nga Tapuwae Kia Ora Tonu, Life and Living in Advanced Age (LiLACs NZ)...
December 19, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29191224/i-knew-how-it-feels-but-couldn-t-save-my-daughter-testimony-of-an-ethiopian-mother-on-female-genital-mutilation-cutting
#4
Yohannes Mehretie Adinew, Beza Tamirat Mekete
BACKGROUND: World Health Organization defines female genital mutilation/cutting as all procedures that involve partial or total removal of the external female genitalia, or other injury to the female genital organs for non-medical reasons. The practice is common in Ethiopia, especially among Somali (99%) ethnic groups. Even though FGM/C is labeled illegal practice according to the revised 2005 Penal Code of the country, the practice is still responsible for misery of many girls in Ethiopia...
December 1, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29162694/an-endogenous-retroviral-envelope-syncytin-and-its-cognate-receptor-identified-in-the-viviparous-placental-mabuya-lizard
#5
Guillaume Cornelis, Mathis Funk, Cécile Vernochet, Francisca Leal, Oscar Alejandro Tarazona, Guillaume Meurice, Odile Heidmann, Anne Dupressoir, Aurélien Miralles, Martha Patricia Ramirez-Pinilla, Thierry Heidmann
Syncytins are envelope genes from endogenous retroviruses that have been captured during evolution for a function in placentation. They have been found in all placental mammals in which they have been searched, including marsupials. Placental structures are not restricted to mammals but also emerged in some other vertebrates, most frequently in lizards, such as the viviparous Mabuya Scincidae. Here, we performed high-throughput RNA sequencing of a Mabuya placenta transcriptome and screened for the presence of retroviral env genes with a full-length ORF...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29149581/family-matters-measuring-impact-through-one-s-academic-descendants
#6
Elizabeth J Marsh
Scientific contributions take many forms, not all of which result in fame or are captured in traditional metrics of success (e.g., h factor). My focus is on one of the most lasting and important contributions a scientist can make: training scientists who go on to train scientists, who in turn train more scientists, etc. Academic genealogies provide many examples of scientists whose names might not be recognizable today but who trained psychologists that went on to publish very influential work. Of course success results from a combination of many factors (including but not limited to the student's abilities and motivation, luck, institutional resources, mentoring, etc...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149165/-reflections-on-the-death-of-my-father
#7
Domenico Ribatti
This short essay aims to provide the reader with some general considerations from a private matter, namely the death of the author's father after a long and disabling neurodegenerative disease. The author's reflection revolves around the meaning of death, the relationship between children and parents, the importance of individual and collective memory, and the role that physicians should have in dealing with relatives of subjects suffering from this type of disease.
November 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29118960/from-the-padua-muscle-days-the-basic-and-applied-myology-and-the-european-journal-of-translational-myology-to-the-a-cm-carraro-foundation-for-translational-myology
#8
Ugo Carraro
As a young researched I had the option to work on skeletal muscle at the University of Padova, Italy. Introduced to the study of muscle denervation/reinnervation, I started a project on long term denervated muscle that still is my primary interest and took me from rodents' models of chronic muscle denervation to human spinal cord injury-related muscle denervation and its managements. On the way, I organized a series of conferences in Euganei Hills, Padua, Italy and an international journal, the Basic and Applied Myology...
June 27, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29111537/synthesis-structure-and-in-vitro-cytotoxicity-of-platinum-ii-complexes-containing-eugenol-and-a-quinolin-8-ol-derived-chelator
#9
Chi Nguyen Thi Thanh, Mai Truong Thi Cam, Thong Pham Van, Long Nguyen, My Nguyen Ha, Luc Van Meervelt
The synthesis of potassium (η(2)-4-allyl-2-methoxyphenol)trichloridoplatinate(II), K[PtCl3(C10H12O2)], (1), starting from Zeise's salt and Ocimum sanctum L. oil has been optimized. Starting from (1), three new platinum(II) complexes, namely (η(2)-4-allyl-2-methoxyphenol)chlorido(2-methylquinolin-8-olato-κ(2)N,O)platinum(II), (2), (η(2)-4-allyl-2-methoxyphenol)chlorido(5-nitroquinolin-8-olato-κ(2)N,O)platinum(II), (3), and (η(2)-4-allyl-2-methoxyphenol)chlorido(5,7-dichloroquinolin-8-olato-κ(2)N,O)platinum(II), [Pt(C9H4Cl2NO)Cl(C10H12O2)], (4), containing eugenol and a quinolin-8-ol derivative (R-OQ), have been synthesized and characterized by elemental analyses, MS, IR, (1)H NMR and NOESY spectra...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29043045/radseq-dataset-with-90-missing-data-fully-resolves-recent-radiation-of-petalidium-acanthaceae-in-the-ultra-arid-deserts-of-namibia
#10
Erin A Tripp, Yi-Hsin Erica Tsai, Yongbin Zhuang, Kyle G Dexter
Deserts, even those at tropical latitudes, often have strikingly low levels of plant diversity, particularly within genera. One remarkable exception to this pattern is the genus Petalidium (Acanthaceae), in which 37 of 40 named species occupy one of the driest environments on Earth, the Namib Desert of Namibia and neighboring Angola. To contribute to understanding this enigmatic diversity, we generated RADseq data for 47 accessions of Petalidium representing 22 species. We explored the impacts of 18 different combinations of assembly parameters in de novo assembly of the data across nine levels of missing data plus a best practice assembly using a reference Acanthaceae genome for a total of 171 sequence datasets assembled...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29021836/specific-protein-biomarker-patterns-for-alzheimer-s-disease-improved-diagnostics-in-progress
#11
REVIEW
Illana Gozes
This short review looks at Alzheimer's disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer's diagnosis. In one paper, we took an approach of selecting a specific target, namely, activity-dependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expression of the regulator of G-protein signaling 2 (RGS2) as a potential AD predictor...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/28981967/lessons-from-a-lost-world-messages-from-the-mental-hospital-era
#12
EDITORIAL
Niall McCrae
No abstract text is available yet for this article.
October 5, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28981697/multiple-modes-of-positive-selection-shaping-the-patterns-of-incomplete-selective-sweeps-over-african-populations-of-drosophila-melanogaster
#13
Ha My T Vy, Yong-Jin Won, Yuseob Kim
It remains a challenge in evolutionary genetics to elucidate how beneficial mutations arise and propagate in a population and how selective pressures on mutant alleles are structured over space and time. By identifying "sweeping haplotypes (SHs)" that putatively carry beneficial alleles and are increasing (or have increased) rapidly in frequency, and surveying the geographic distribution of SH frequencies, we can indirectly infer how selective sweeps unfold in time and thus which modes of positive selection underlie those sweeps...
November 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28948041/characterization-of-posa-and-posa-like-virus-genomes-in-fecal-samples-from-humans-pigs-rats-and-bats-collected-from-a-single-location-in-vietnam
#14
Bas B Oude Munnink, My V T Phan, Peter Simmonds, Marion P G Koopmans, Paul Kellam, Lia van der Hoek, Matthew Cotten
Porcine stool-associated RNA virus (posavirus), and Human stool-associated RNA virus (husavirus) are viruses in the order Picornavirales recently described in porcine and human fecal samples. The tentative group (Posa and Posa-like viruses: PPLVs) also includes fish stool-associated RNA virus (fisavirus) as well as members detected in insects (Drosophila subobscura and Anopheles sinensis) and parasites (Ascaris suum). As part of an agnostic deep sequencing survey of animal and human viruses in Vietnam, we detected three husaviruses in human fecal samples, two of which share 97-98% amino acid identity to Dutch husavirus strains and one highly divergent husavirus with only 25% amino acid identity to known husaviruses...
July 2017: Virus Evolution
https://www.readbyqxmd.com/read/28891342/towards-a-critical-health-equity-research-stance-why-epistemology-and-methodology-matter-more-than-qualitative-methods
#15
Lisa Bowleg
Qualitative methods are not intrinsically progressive. Methods are simply tools to conduct research. Epistemology, the justification of knowledge, shapes methodology and methods, and thus is a vital starting point for a critical health equity research stance, regardless of whether the methods are qualitative, quantitative, or mixed. In line with this premise, I address four themes in this commentary. First, I criticize the ubiquitous and uncritical use of the term health disparities in U.S. public health. Next, I advocate for the increased use of qualitative methodologies-namely, photovoice and critical ethnography-that, pursuant to critical approaches, prioritize dismantling social-structural inequities as a prerequisite to health equity...
September 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28886750/evidence-based-gene-models-for-structural-and-functional-annotations-of-the-oil-palm-genome
#16
Kuang-Lim Chan, Tatiana V Tatarinova, Rozana Rosli, Nadzirah Amiruddin, Norazah Azizi, Mohd Amin Ab Halim, Nik Shazana Nik Mohd Sanusi, Nagappan Jayanthi, Petr Ponomarenko, Martin Triska, Victor Solovyev, Mohd Firdaus-Raih, Ravigadevi Sambanthamurthi, Denis Murphy, Eng-Ti Leslie Low
BACKGROUND: Oil palm is an important source of edible oil. The importance of the crop, as well as its long breeding cycle (10-12 years) has led to the sequencing of its genome in 2013 to pave the way for genomics-guided breeding. Nevertheless, the first set of gene predictions, although useful, had many fragmented genes. Classification and characterization of genes associated with traits of interest, such as those for fatty acid biosynthesis and disease resistance, were also limited...
September 8, 2017: Biology Direct
https://www.readbyqxmd.com/read/28862142/cancer-screening-for-older-people-to-screen-or-not-to-screen
#17
REVIEW
C Ky Lai, A Igarashi, N My Lau, C Tk Yu
In this scoping review, the evidence of the benefits of screening older people for the five most common types of cancer in Hong Kong, namely colorectal, lung, breast, liver, and prostate cancers, is discussed. Although cancer treatments can be extensive and a good prognosis is less likely if cancer is diagnosed at a late stage, screening programmes for older people in primary care remain a matter of contention. The general recommendation for the screening of older people is to adopt an individualised approach that takes account of not only age but also co-morbidity, life expectancy, harms and benefits, and patient's preference...
October 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28839923/why-developmental-niche-construction-is-not-selective-niche-construction-and-why-it-matters
#18
Karola Stotz
In the last decade, niche construction has been heralded as the neglected process in evolution. But niche construction is just one way in which the organism's interaction with and construction of the environment can have potential evolutionary significance. The constructed environment does not just select for, it also produces new variation. Nearly 3 decades ago, and in parallel with Odling-Smee's article 'Niche-constructing phenotypes', West and King introduced the 'ontogenetic niche' to give the phenomena of exogenetic inheritance a formal name...
October 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28776482/procrastination-as-a-self-regulation-failure-the-role-of-impulsivity-and-intrusive-thoughts
#19
Marie My Lien Rebetez, Lucien Rochat, Catherine Barsics, Martial Van der Linden
Procrastination has been described as the quintessence of self-regulatory failure. This study examines the relationships between this self-regulatory failure and other manifestations of self-regulation problems, namely impulsivity and intrusive thoughts. One hundred and forty-one participants completed questionnaires assessing procrastination, impulsivity (in particular, the urgency and lack of perseverance dimensions), and intrusive thoughts (i.e., rumination and daydreaming). Main results show that urgency mediated the association between rumination and procrastination, whereas rumination did not mediate the relation between urgency and procrastination...
January 1, 2017: Psychological Reports
https://www.readbyqxmd.com/read/28766419/mental-health-nurse-helps-me-feel-empowered-and-independent
#20
(no author information available yet)
Nadine and I met during my first admission to the psychiatric ward at Dr Gray's Hospital, Elgin, Moray, in 2003. She was my named nurse at the time, and has been my community mental health nurse for the past three years.
August 2, 2017: Nursing Standard
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