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Diabetic nephropathy differential diagnosis

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https://www.readbyqxmd.com/read/27688084/-diabetic-nephropathy-in-a-non-diabetic-patient
#1
Olga Balafa, Georgios Liapis, Paraskevi Pavlakou, Georgios Baltatzis, Rigas Kalaitzidis, Moses Elisaf
Kimmelstiel and Wilson originally described nodular glomerulosclerosis as the pathognomonic lesion of diabetic nephropathy. Nevertheless, nodular glomerulosclerosis pattern can rarely occur in non-diabetic patients. In such cases, the differential diagnosis includes membranoproliferative glomerulonephritis, light or heavy chain deposition disease, amyloidosis, fibrillary and immunotactoid glomerulonephritis and chronic hypoxic or ischemic conditions. In cases that the above entities cannot be proven, the term idiopathic nodular glomerulosclerosis is given...
December 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27457509/diabetic-nephropathy-in-type-1-diabetes-a-review-of-early-natural-history-pathogenesis-and-diagnosis
#2
Nektaria Papadopoulou-Marketou, George P Chrousos, Christina Kanaka-Gantenbein
Diabetic nephropathy constitutes a devastating complication in patients with type 1 diabetes mellitus, and its diagnosis is traditionally based on microalbuminuria. The aim of this review is to update through the medical literature the suggested early natural course of diabetic nephropathy, the theories behind the pathways of its pathogenesis, and its diagnosis. Poor glycemic control, dyslipidemia, smoking, advanced glycation end products, and environmental and genetic clues play an important role in the development of diabetic nephropathy...
July 25, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27003767/spectrum-of-biopsy-proven-renal-diseases-in-patients-with-type-2-diabetes-mellitus-a-single-center-study
#3
Malgorzata Wągrowska-Danilewicz, Marian Danilewicz
This is the first report from Poland documenting biopsy-proven renal diseases in type 2 diabetes mellitus. We analyzed the data of 76 patients with type 2 diabetes who underwent renal biopsy and were diagnosed in the Department of Nephropathology, Medical University of Lodz. The patients were divided into the following three groups according to the histological diagnosis: group I - isolated non-diabetic renal disease (NDRD); group II - NDRD superimposed on underlying diabetic nephropathy (NDRD + DN); and group III - isolated diabetic nephropathy (DN)...
December 2015: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/26904690/diabetic-retinopathy-screening-ratio-is-improved-when-using-a-digital-nonmydriatic-fundus-camera-onsite-in-a-diabetes-outpatient-clinic
#4
Pia Roser, Hannes Kalscheuer, Jan B Groener, Daniel Lehnhoff, Roman Klein, Gerd U Auffarth, Peter P Nawroth, Florian Schuett, Gottfried Rudofsky
OBJECTIVE: To evaluate the effect of onsite screening with a nonmydriatic, digital fundus camera for diabetic retinopathy (DR) at a diabetes outpatient clinic. RESEARCH DESIGN AND METHODS: This cross-sectional study included 502 patients, 112 with type 1 and 390 with type 2 diabetes. Patients attended screenings for microvascular complications, including diabetic nephropathy (DN), diabetic polyneuropathy (DP), and DR. Single-field retinal imaging with a digital, nonmydriatic fundus camera was used to assess DR...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26634140/myeloma-associated-systemic-amyloidosis-masquerading-as-nash-associated-cirrhosis-and-diabetic-microvascular-complications
#5
Partha Pal, Sayantan Ray, Sisir Kumar Patra, Anjan Kumar Das, Subhasis Dey, Rintu George
Authors describe the case of a 60-year-old diabetic man who presented with jaundice, ascites and significant weight loss over a period of 2 months. Physical examination revealed firm hepatomegaly with ascites. On evaluation, nephropathy, axonal neuropathy, carpal tunnel syndrome and decompensated cryptogenic liver disease with portal hypertension were found fitting with the diagnosis of diabetic nephropathy and neuropathy and nonalcoholic steato-hepatitis-associated cirrhosis, respectively. It was only after tissue diagnosis and serum protein electrophoresis that a definitive diagnosis of myeloma-related amyloidosis was made...
April 2015: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/26630791/-the-great-imitator-clavicular-tuberculosis-mimics-a-metastatic-neoplasm
#6
Takahiro Mikawa, Kazuyasu Miyoshi, Koji Fujita, Ryota Hase, Naoto Hosokawa
In the same manner as syphilis, tuberculosis (TB) was often called "The Great Imitator". We have to consider not only malignancies but also TB as a differential diagnosis when we find any tumorous regions. We report herein on a rare case, clavicular osteomyelitis due to TB. A 72-year-old female, with diabetic nephropathy, was on maintenance hemodialysis. She had a fall 2 months prior to admission followed by pain around her right clavicle. Ulceration occurred in that region a month prior to admission, and CT scan revealed a fracture of the right clavicle with a tumor surrounding that area...
September 2015: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
https://www.readbyqxmd.com/read/26608305/differential-urinary-glycoproteome-analysis-of-type-2-diabetic-nephropathy-using-2d-lc-ms-ms-and-itraq-quantification
#7
Zhengguang Guo, Xuejiao Liu, Menglin Li, Chen Shao, Jianling Tao, Wei Sun, Mingxi Li
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of chronic kidney failure and end-stage kidney disease. More accurate and non-invasive test for the diagnosis and monitoring the progression of DN is urgently needed for the better care of such patients. METHODS: In this study we utilized urinary glycoproteome to discover the differential proteins during the course of type 2 DN. The urinary glycoproteins from normal controls, normalbuminuira, microalbuminura, and macroalbuminuria patients were enriched by concanavalin A (ConA) and analyzed by 2DLC/MS/MS and isobaric tags for relative and absolute quantitation quantification...
2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/26568188/renal-involvement-in-primary-sj%C3%A3-gren-syndrome
#8
REVIEW
Hélène François, Xavier Mariette
Primary Sjögren syndrome (pSS) is an autoimmune disorder characterized by lymphoplasmacytic infiltration of the exocrine (salivary and lachrymal) glands that results in sicca symptoms (dryness of the eyes and mouth). Systemic complications can occur in pSS, but renal involvement is rare, affecting <10% patients. The most frequent form of nephropathy in pSS is tubulointerstitial nephritis (TIN), in which infiltration of the kidney by plasma cells is a key feature and shows similarity to the lymphoplasmacytic infiltration of the salivary glands...
February 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/26072307/kidney-tissue-proteomics-reveals-regucalcin-downregulation-in-response-to-diabetic-nephropathy-with-reflection-in-urinary-exosomes
#9
Irene Zubiri, Maria Posada-Ayala, Alberto Benito-Martin, Aroa S Maroto, Marta Martin-Lorenzo, Pablo Cannata-Ortiz, Fernando de la Cuesta, Laura Gonzalez-Calero, Maria G Barderas, Beatriz Fernandez-Fernandez, Alberto Ortiz, Fernando Vivanco, Gloria Alvarez-Llamas
Diabetic nephropathy (DN) is a major complication of diabetes mellitus and the most frequent cause of end-stage renal disease. DN progresses silently and without clinical symptoms at early stages. Current noninvasive available markers as albuminuria account with severe limitations (late response, unpredictable prognosis, and limited sensitivity). Thus, it urges the discovery of novel markers to help in diagnosis and outcome prediction. Tissue proteomics allows zooming-in where pathophysiological changes are taking place...
November 2015: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/26070216/clinical-evidence-of-diabetes-mellitus-end-organ-damage-as-risk-factor-for-falls-complicated-by-hip-fracture-a-multi-center-study-of-1225-patients
#10
MULTICENTER STUDY
Francesc Formiga, David Chivite, Domingo Ruiz, Margarita Navarro, J M Perez Castejon, Enric Duaso, Abelardo Montero, Alfonso Lopez-Soto, Xavier Corbella
AIMS: To identify the differential characteristics of patients with type 2 diabetes mellitus (T2DM) complicated by end-organ damage who experience a fall-related hip fracture. METHODS: We analyzed the socio-demographic data and index fall clinical characteristics of a group of patients with nephropathy, neuropathy or retinopathy related to T2DM consecutively admitted to six hospitals in Barcelona, Spain because of a fall-related hip fracture. RESULTS: Out of 1225 patients admitted because of a fall-related hip fracture, 107 (8...
August 2015: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/25994657/con-biomarkers-in-glomerular-diseases-putting-the-cart-before-the-wheel
#11
An S De Vriese, Fernando C Fervenza
Biomarkers have been increasingly sought to improve diagnosis as well as predict prognosis and/or response to therapy. However, they should not replace sound clinical judgment and therapeutic measures. The present article aims to highlight the issues with biomarker research in three selected entities. In focal segmental glomerulosclerosis, many studies fail to differentiate cases of primary versus secondary forms leading to conclusions that are uninterpretable. Biomarkers have also been sought to predict development of diabetic nephropathy but this research should not supersede efforts aimed to optimize treatment of diabetes...
June 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25852909/urinary-angiotensinogen-as-a-potential-biomarker-of-diabetic-nephropathy
#12
Bancha Satirapoj, Nuttawut Siritaweesuk, Ouppatham Supasyndh
BACKGROUND: Activation of the renin-angiotensin-aldosterone system (RAAS) is an important mediator of diabetic nephropathy. Urinary angiotensinogen, a novel biomarker of the intrarenal RAAS, is associated with progressive kidney injury. In this study, the authors investigated the determinants of urinary angiotensinogen and its associations with staging of diabetic nephropathy. METHODS: Random urine samples were collected from the patients with type 2 diabetes with normoalbuminuria (n = 52), microalbuminuria (n = 52) and macroalbuminuria (n = 51) for the measurement of angiotensinogen by sensitive and specific ELISAs...
August 2014: Clinical Kidney Journal
https://www.readbyqxmd.com/read/25802733/a-new-classification-of-diabetic-nephropathy-2014-a-report-from-joint-committee-on-diabetic-nephropathy
#13
Masakazu Haneda, Kazunori Utsunomiya, Daisuke Koya, Tetsuya Babazono, Tatsumi Moriya, Hirofumi Makino, Kenjiro Kimura, Yoshiki Suzuki, Takashi Wada, Susumu Ogawa, Masaaki Inaba, Yoshihiko Kanno, Takashi Shigematsu, Ikuto Masakane, Ken Tsuchiya, Keiko Honda, Kazuko Ichikawa, Kenichiro Shide
The Joint Committee on Diabetic Nephropathy has revised its Classification of Diabetic Nephropathy (Classification of Diabetic Nephropathy 2014) in line with the widespread use of key concepts, such as the estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). In revising the Classification, the Committee carefully evaluated, as relevant to current revision, the report of a study conducted by the Research Group of Diabetic Nephropathy, Ministry of Health, Labor and Welfare of Japan. Major revisions to the Classification are summarized as follows: (i) eGFR is substituted for GFR in the Classification; (ii) the subdivisions A and B in stage 3 (overt nephropathy) have been reintegrated; (iii) stage 4 (kidney failure) has been redefined as a GFR <30 mL/min/1...
March 2015: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/25527479/a-new-classification-of-diabetic-nephropathy-2014-a-report-from-joint-committee-on-diabetic-nephropathy
#14
REVIEW
Masakazu Haneda, Kazunori Utsunomiya, Daisuke Koya, Tetsuya Babazono, Tatsumi Moriya, Hirofumi Makino, Kenjiro Kimura, Yoshiki Suzuki, Takashi Wada, Susumu Ogawa, Masaaki Inaba, Yoshihiko Kanno, Takashi Shigematsu, Ikuto Masakane, Ken Tsuchiya, Keiko Honda, Kazuko Ichikawa, Kenichiro Shide
The Joint Committee on Diabetic Nephropathy has revised its Classification of Diabetic Nephropathy (Classification of Diabetic Nephropathy 2014) in line with the widespread use of key concepts such as the estimated glomerular filtration rate (eGFR) and chronic kidney disease. In revising the Classification, the Committee carefully evaluated, as relevant to current revision, the report of a study conducted by the Research Group of Diabetic Nephropathy, Ministry of Health, Labour and Welfare of Japan. Major revisions to the Classification are summarized as follows: (1) eGFR is substituted for GFR in the Classification; (2) the subdivisions A and B in stage 3 (overt nephropathy) have been reintegrated; (3) stage 4 (kidney failure) has been redefined as a GFR less than 30 mL/min/1...
February 2015: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/25472509/practice-context-affects-efforts-to-improve-diabetes-care-for-primary-care-patients-a-pragmatic-cluster-randomized-trial
#15
RANDOMIZED CONTROLLED TRIAL
L Miriam Dickinson, W Perry Dickinson, Paul A Nutting, Lawrence Fisher, Marjie Harbrecht, Benjamin F Crabtree, Russell E Glasgow, David R West
BACKGROUND: Efforts to improve primary care diabetes management have assessed strategies across heterogeneous groups of patients and practices. However, there is substantial variability in how well practices implement interventions and achieve desired outcomes. OBJECTIVE: To examine practice contextual features that moderate intervention effectiveness. DESIGN: Secondary analysis of data from a cluster randomized trial of three approaches for implementing the Chronic Care Model to improve diabetes care...
April 2015: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/25130030/-classification-of-diabetic-nephropathy-2014
#16
REVIEW
Masakazu Haneda, Kazunori Utsunomiya, Daisuke Koya, Tetsuya Babazono, Tatsumi Moriya, Hirofumi Makino, Kenjiro Kimura, Yoshiki Suzuki, Takashi Wada, Susumu Ogawa, Masaaki Inaba, Yoshihiko Kanno, Takashi Shigematsu, Ikuto Masakane, Ken Tsuchiya, Keiko Honda, Kazuko Ichikawa, Kenichiro Shide
The Committee on Diabetic Nephropathy revised the classification of diabetic nephropathy in view of the current status of eGFR and CKD in Japan. To make revisions for the classification of diabetic nephropathy 2014, the Committee carefully evaluated the report of the Research Group on Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. The major revisions made were as follows: 1. eGFR can be used for the evaluation of GFR; 2. In stage 3 (overt nephropathy), A and B were combined; 3. Stage 4 (renal failure) was defined as GFR less than 30 mL/min/1...
2014: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/24956882/-nephrotic-syndrome-in-diabetic-nephropathy-and-diabetes
#17
REVIEW
Miho Shimizu, Takashi Wada
No abstract text is available yet for this article.
2014: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/24798594/proteomic-studies-in-endemic-nephropathy
#18
REVIEW
Vladisav Stefanović, Ivana Pešić, Rade Cukuranović, Gerhard Müller, Hassan Dihazi
Endemic nephropathy (EN) is a chronic tubulointerstitial nephropathy with an early insidious and slow development into terminal renal failure. Proteomics is the systematic study of a proteome, which is the total protein content of a cell, organism or body fluids. Application of proteomic technologies in nephrology has enabled more detailed analyses of protein functions and examined their importance in various physiological and pathological states. Biomarkers with high specificity and sensitivity to early diagnosis are needed for a better understanding of the mechanisms of EN development and its consequences...
2014: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/24670455/-value-of-plasma-growth-differentiation-factor-15-in-diagnosis-and-evaluation-of-type-2-diabetic-nephropathy
#19
Hui Li, Fang Gao, Yaoming Xue, Yi Qian
OBJECTIVE: To detect the plasma level of growth differentiation factor-15 (GDF-15) in patients of type 2 diabetic nephropathy and assess its value in diagnosis and evaluation of type 2 diabetic nephropathy. METHODS: Thirty type 2 diabetic patients with normoalbuminuria, 20 with microalbuminuria, and 30 with macroalbuminuria, diagnosed according to Mogensen's criteria, were examined for plasma GDF-15 level using enzyme-linked immunosorbent assay. RESULTS: The patients with macroalbuminuria had significantly higher plasma GDF-15 level than those with microalbuminuria and normoalbuminuria [1773...
March 2014: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/24591769/urine-annexin-a1-as-an-index-for-glomerular-injury-in-patients
#20
Shuk-Man Ka, Pei-Yi Tsai, Tai-Kuang Chao, Shun-Min Yang, Yi-Jen Hung, Jin-Shuen Chen, Hao-Ai Shui, Ann Chen
BACKGROUND: We recently demonstrated high urine levels of annexin A1 (ANXA1) protein in a mouse Adriamycin-induced glomerulopathy (ADG) model. OBJECTIVE: To establish ANXA1 as a potential biomarker for glomerular injury in patients. METHODS: A time-course study in the mouse ADG model, followed by renal tissues and urine samples from patients with various types of glomerular disorders for ANXA1. RESULTS: Urinary ANXA1 protein was (1) detectable in both the ADG model and in patients except those with minimal change disease (MCD); (2) positively correlated with renal lesions in patients; and (3) early detectable in diabetes patients with normoalbuminuria...
2014: Disease Markers
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