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Local endometrial injury

Aleyamma Tk, Himanshu Singhal, Prasanna S Premkumar, Mousumi Acharya, Mohan S Kamath, Korula George
OBJECTIVE: To evaluate the effectiveness of local endometrial injury in women undergoing in vitro fertilization (IVF) with at least one previous unsuccessful attempt. STUDY DESIGN: Randomized controlled trial. Recruited women were randomized into two groups. In group A (pipelle group), women underwent pipelle biopsy twice in the luteal phase in the cycle prior to IVF. In group B (control), women did not undergo any intervention prior to IVF. The primary outcome was clinical pregnancy rate...
May 4, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
M Canis, N Bourdel, C Houlle, A-S Gremeau, R Botchorishvili, S Matsuzaki
OBJECTIVE: The study was performed to evaluate whether trauma is an initial event of development of endometriosis. METHOD: Using Medline database from January 1960 up to December 2014, a systematic review was made of all published studies using the keywords trauma, healing, injury, infection, hyperperistaltism, stretch and endometriosis, adenomyosis and trauma. Studies and review articles written in French and/or in English related to the topic were included and reviewed independently by two authors...
March 2017: Journal of gynecology obstetrics and human reproduction
Medhat E E Helmy, Mohammad A Maher, Nabih I Elkhouly, Mahmoud Ramzy
OBJECTIVE: To investigate the effect of endometrial injury on pregnancy outcomes among infertile women taking clomifene citrate. METHODS: A prospective randomized trial was undertaken at an Egyptian hospital between January 26, 2015, and July 17, 2016. Eligible women (≥1 year primary/secondary/unexplained infertility, aged 20-35 years, day-2 follicle-stimulating hormone <12 IU/L, normal prolactin/thyroid function/uterine cavity, ≥1 patent tube, male partner with normal semen count and motility, 3 cycles of clomifene citrate without success) were randomly allocated (1:1) using computer-generated numbers into intervention (received endometrial injury on cycle day 15-24) or control groups (sham procedure)...
April 11, 2017: International Journal of Gynaecology and Obstetrics
Milan Reljič, Jure Knez, Vilma Kovač, Borut Kovačič
PURPOSE: The purpose of this study was to find out the most important prognostic factors for achieving a pregnancy after in vitro fertilization (IVF) in women with history of repeated unsuccessful IVF attempts. METHODS: We analyzed factors affecting pregnancy rate in a retrospective study including 429 IVF/ICSI cycles performed in women younger than 40 years with at least three previous consecutive failed IVF/ICSI attempts. RESULTS: Clinical pregnancy was observed in 140/429 (32...
June 2017: Journal of Assisted Reproduction and Genetics
Aleksandra Zygula, Iwona Szymusik, Barbara Grzechocinska, Piotr Marianowski, Miroslaw Wielgos
Implantation failure is one of the major factors limiting success of in vitro fertilization (IVF) treatment. According to ESHRE 2009 data only 32% of fresh embryo transfers resulted in clinical pregnancies. There are many ideas to improve the treatment outcomes, endometrial injury being one of them. It has been suggested that local endometrial injury, performed either by pipelle biopsy or hysteroscopy, may increase clinical pregnancy rate. However, up to date literature is widely disparate on that subject. There is no conclusion with regard to optimal timing, the number and technique of the procedure...
November 2016: Neuro Endocrinology Letters
Ensieh Shahrokh-Tehraninejad, Minoo Dashti, Batool Hossein-Rashidi, Elham Azimi-Nekoo, Fedyeh Haghollahi, Vahid Kalantari
Objective: Repeated implantation failure (RIF) is a condition in which the embryos implantation decreases in the endometrium. So, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. Materials and methods: In this simple randomized clinical trial (RCT), a total of 120 patients were selected. The participants were less than 40 years old, and they are in their minimum two cycles of vitro fertilization (IVF). Patients were divided randomly into two groups of LEI (Local endometrial injury) and a control group (n = 60 in each group)...
September 2016: Journal of Family & Reproductive Health
Saghar Salehpour, Marzieh Zamaniyan, Nasrin Saharkhiz, Shahrzad Zadeh Modares, Sedighe Hosieni, Samira Seif, Narges Malih, Parinaz Rezapoor, Mohammad-Reza Sohrabi
BACKGROUND: Recurrent implantation failure is one of the most issues in IVF cycles. Some researchers found that beneficial effects of endometrial Scratching in women with recurrent implantation failure, while some authors demonstrated contrary results. OBJECTIVE: The present study aimed to investigate the effect of intrauterine. Saline infusion as a form of endometrial injury, during fresh in vitro fertilization-embryo transfer cycle, among patients with recurrent implantation failure...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
Abbas Aflatoonian, Ramesh Baradaran Bagheri, Robabe Hosseinisadat
BACKGROUND: Implantation failure is one of the most important factors limiting success in IVF treatment. The majority of trials have demonstrated favorable effect of endometrial injury on implantation success rate especially in women with recurrent implantation failure, while some studies failed to detect any benefit. OBJECTIVE: The purpose of our trial was to explore whether endometrial injury in luteal phase prior to frozen-thawed embryo transfer cycles would improve pregnancy outcomes? MATERIALS AND METHODS: We conducted a prospective controlled trial of 93 consecutive subjects at a research and clinical center for infertility...
July 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
Tarek Shokeir, Mohamed Ebrahim, Hosam El-Mogy
AIM: To evaluate the efficacy of a hysteroscopic site-specific local endometrial injury (LEI) in a group of women with unexplained infertility (UI) undergoing expectant management with no fertility treatment versus no intervention. METHODS: This open-label, randomized controlled trial (RCT) was conducted between June 2013 and July 2015. Hysteroscopic site-specific LEI was determined by patient identification number, and 120 women were included. Eligible participants were randomly assigned to receive either a single, site-specific LEI guided by hysteroscopy (study group, n = 60) or no intervention (control group, n = 60)...
November 2016: Journal of Obstetrics and Gynaecology Research
Xishi Liu, Minhong Shen, Qiuming Qi, Hongqi Zhang, Sun-Wei Guo
STUDY QUESTION: Do platelets play any role in the development of adenomyosis? SUMMARY ANSWER: As in endometriosis, adenomyotic lesions show significantly increased platelet aggregation, increased expression of transforming growth factor (TGF)-β1, phosphorylated Smad3, markers of epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transdifferentiation (FMT), and smooth muscle metaplasia (SMM), in conjunction with increased fibrosis as compared with normal endometrium...
April 2016: Human Reproduction
Kotaro Kitaya, Hidehiko Matsubayashi, Yukiko Takaya, Rie Nishiyama, Kohei Yamaguchi, Tomomoto Ishikawa
Local endometrial injury (LEI) has been performed as a promising medical intervention to improve the pregnancy outcome in infertile women suffering from repeated implantation failure (RIF) in in vitro fertilization-embryo transfer cycles. The effect of LEI, however, remains controversial. The aim of this retrospective study was to identify the subgroups of patients with RIF who benefit from LEI. We compared the clinical parameters between the patients who had had a clinical pregnancy in the subsequent embryo transfer cycle following the LEI cycle (LEI-CP group, n = 94) and those who had resulted in negative pregnancy test (LEI-NP group, n = 114)...
July 2016: Gynecological Endocrinology
Ann Liu, Eric W Sankey, C Rory Goodwin, Thomas A Kosztowski, Benjamin D Elder, Ali Bydon, Timothy F Witham, Jean-Paul Wolinsky, Ziya L Gokaslan, Daniel M Sciubba
OBJECTIVE: Spinal metastases from gynecological cancers are rare, with few cases reported in the literature. In this study, the authors examine a series of patients with spinal metastases from gynecological cancer and review the literature. METHODS: The cases of 6 consecutive patients who underwent spine surgery for metastatic gynecological cancer between 2007 and 2012 at a single institution were retrospectively reviewed. The recorded demographic, operative, and postoperative factors were reviewed, and the functional outcomes were determined by change in Karnofsky Performance Scale and the American Spine Injury Association (ASIA) score during follow-up...
January 2016: Journal of Neurosurgery. Spine
Y Tada, K Kitaya, N Amano, M Kobatake, T Hayashi, S Taguchi, M Funabiki, Y Nakamura
PURPOSE OF INVESTIGATION: To assess if a history of repeated implantation failure (RIF) or local endometrial injury (LEI) for RIF affects the pregnancy course in women who conceived in the subsequent in vitro fertilization (IVF)-embryo/blastocyst transfer (ET/BT) cycle. MATERIALS AND METHODS: Of 42 pregnant women with a history of three consecutive failed ET/BT cycles with negative pregnancy tests, 11 patients had a clinical pregnancy in the immediate subsequent ET/BT cycle following (the RIF group), whereas 31 patients had a clinical pregnancy in the subsequent ET/BT cycle following single curettage LEI in the proliferative phase of the preceding spontaneous cycle (the RIF/LEI group)...
2015: Clinical and Experimental Obstetrics & Gynecology
Philippe Laberge, Nicholas Leyland, Ally Murji, Claude Fortin, Paul Martyn, George Vilos, Nicholas Leyland, Wendy Wolfman, Catherine Allaire, Alaa Awadalla, Sheila Dunn, Mark Heywood, Madeleine Lemyre, Violaine Marcoux, Frank Potestio, David Rittenberg, Sukhbir Singh, Grace Yeung
BACKGROUND: Abnormal uterine bleeding (AUB) is the direct cause of a significant health care burden for women, their families, and society as a whole. Up to 30% of women will seek medical assistance for the problem during their reproductive years. OBJECTIVE: To provide current evidence-based guidelines on the techniques and technologies used in endometrial ablation (EA), a minimally invasive technique for the management of AUB of benign origin. METHODS: Members of the guideline committee were selected on the basis of individual expertise to represent a range of practical and academic experience in terms of both location in Canada and type of practice, as well as subspecialty expertise and general background in gynaecology...
April 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Xiao-Hui Zhang, Zhao-Zhao Liu, Mao-Xing Tang, Yong-Hong Zhang, Lian Hu, Ai-Hua Liao
OBJECTIVE: To establish a mouse model for endometrial injury and determine the underlying mechanism regarding its favorable effect on embryo implantation. STUDY DESIGN: Female Kunming mice were randomly allocated into 4 groups: group I, normal control; group II, injury procedure control; and group III and group IV, the mice being scratched with a blunt syringe on the right uterine horn or both, respectively. All the mice were mated with the males during the next estrus phase...
November 2015: Reproductive Sciences
Afsoon Zarei, Saeed Alborzi, Nasrin Dadras, Ghazal Azadi
BACKGROUND: Implantation is considered as the rate-limiting step in success of assisted reproduction techniques, and intrauterine insemination cycles. It might be affected by ovarian superovulation and endometrial local scratching. OBJECTIVE: This study aims to investigate the effect of local endometrial injury on the outcome of IUI cycles. MATERIALS AND METHODS: In this randomized clinical trial 144 women with unexplained infertility, mild male factor, and mild endometriosis randomly divided into two study groups through block randomization...
September 2014: Iranian Journal of Reproductive Medicine
Y Gnainsky, I Granot, P Aldo, A Barash, Y Or, G Mor, N Dekel
A decade ago, we first reported that endometrial biopsy significantly improves the success of pregnancy in IVF patients with recurrent implantation failure, an observation that was later confirmed by others. Recently, we have demonstrated that this treatment elevated the levels of endometrial pro-inflammatory cytokines and increased the abundance of macrophages (Mac) and dendritic cells (DCs). We therefore hypothesised that the biopsy-related successful pregnancy is secondary to an inflammatory response, and aimed at deciphering its mechanism of action...
January 2015: Reproduction: the Official Journal of the Society for the Study of Fertility
Mustafa Kara, Turgut Aydin, Nurettin Turktekin, Karacavus S
BACKGROUND: The latest studies reported that local endometrial injury is a useful method to improve the success of IVF-ICSI outcome. OBJECTIVE: To assess whether local endometrial injury occurred by Pipelle in the spontaneous cycle could improve implantation rate, cleavage rate, and pregnancy outcome in the subsequent IVF-ICSI cycle in patients who had recurrent IVF failure. MATERIALS AND METHODS: An endometrial biopsy was performed on day 21(st) in 41 patients as intervention group in this retrospective cross-sectional study...
November 2012: Iranian Journal of Reproductive Medicine
E Jouglar, I Barillot
Radiation oncology is a field in which many technologic improvements have been made over the past decades. External beam radiotherapy has evolved from treatment fields planned on X-rays to 3-dimensional planning with fusion with MRI's and PET images. Recently, intensity-modulated radiotherapy has been tested for many cancer localizations, and its role in the treatment of gynecologic cancers is still under evaluation. Potential benefits are well known: decrease of treatment toxicity, improvement of efficacy through better dose delivery...
October 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Lena Dain, Kamal Ojha, David Bider, Jacob Levron, Viktor Zinchenko, Sharon Walster, Martha Dirnfeld
OBJECTIVE: To evaluate the effect of local endometrial injury (LEI) on clinical outcomes in ovum donation recipients. DESIGN: Retrospective cohort analysis of ovum donation cycles conducted from 2005 to 2012. SETTING: Two private IVF centers. PATIENT(S): Total 737 ovum donation cycles. INTERVENTION(S): LEI by endometrial "scratch" with the use of a Pipelle catheter. MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth rates...
October 2014: Fertility and Sterility
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