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Local endometrial injury

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https://www.readbyqxmd.com/read/28964963/comparison-of-pregnancy-rates-between-patients-with-and-without-local-endometrial-scratching-before-intrauterine-insemination
#1
G C Senocak, O E Yapca, B Borekcl
OBJECTIVES: To determine the implantation success of local endometrial injury in patients undergoing intrauterine insemination following ovulation induction with gonadotropins as an infertility treatment. MATERIAL AND METHODS: In this prospective randomized controlled trial, ovulation induction was performed with gonadotropins in 80 patients following intrauterine insemination. In 40 patients, local endometrial injury (scratch) was performed in the midluteal phase of the cycle preceding ovarian stimulation with a Novak curette to the posterior side of the endometrial cavity...
September 28, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/28938896/effect-of-local-endometrial-injury-in-proliferative-vs-luteal-phase-on-ivf-outcomes-in-unselected-subfertile-women-undergoing-in-vitro-fertilization
#2
Wenjie Liu, Reshef Tal, He Chao, Minghui Liu, Ying Liu
BACKGROUND: Mechanical endometrial injury prior to IVF has been suggested as a means to increase implantation rates by improving endometrial receptivity. However, the effects of endometrial injury in proliferative vs. luteal phase have not been studied before. This study aimed to explore whether endometrial injury in the proliferative phase of the preceding cycle before in vitro fertilization/embryo transfer (IVF-ET) improves the clinical outcomes in unselected subfertile women compared with injury in luteal phase...
September 22, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28782281/systemic-administration-of-bone-marrow-derived-cells-leads-to-better-uterine-engraftment-than-use-of-uterine-derived-cells-or-local-injection
#3
Ying Liu, Reshef Tal, Nicola Pluchino, Ramanaiah Mamillapalli, Hugh S Taylor
Stem cells are recruited to the uterus where they differentiate into endometrial cells and have been suggested as potential therapy for uterine injury such as Asherman's syndrome. However, it is unknown whether local intrauterine injection may result in better stem cell engraftment of the uterus compared with systemic administration, and whether uterine-derived cells (UDCs) may confer an advantage over BM-derived cells (BMDCs). Mice underwent local injury to a single uterine horn. Green fluorescent protein (GFP)-expressing BMDCs, UDCs or saline (control) were injected either intravenously or locally (uterine lumen) into wild-type recipients...
August 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28752711/-establishment-of-mouse-endometrial-injury-model-by-curettage-or-coagulation
#4
Wang Yanpeng, Huang Qiongxiao, X U Sheng, Shu Jing
Objective: To establish mouse endometrial injury model by curettage or coagulation. Methods: Female ICR mice were randomly allocated into 2 groups: in curettage group, a blunt 20G needle was inserted in one uterine horn with 0.05 megapascals negative pressure; in coagulation group, one uterine horn was coagulated using a monopolar electric needle with 0.5 watts power. In both groups the contra-lateral uterine horn was used as control. The morphological changes and thickness of endometrium were evaluated 1 week after operation...
March 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28511086/local-endometrial-injury-in-women-with-failed-ivf-undergoing-a-repeat-cycle-a-randomized-controlled-trial
#5
Aleyamma Tk, Himanshu Singhal, Prasanna S Premkumar, Mousumi Acharya, Mohan S Kamath, Korula George
OBJECTIVE: To evaluate the effectiveness of local endometrial injury in women undergoing in vitro fertilization (IVF) with at least one previous unsuccessful attempt. STUDY DESIGN: Randomized controlled trial. Recruited women were randomized into two groups. In group A (pipelle group), women underwent pipelle biopsy twice in the luteal phase in the cycle prior to IVF. In group B (control), women did not undergo any intervention prior to IVF. The primary outcome was clinical pregnancy rate...
July 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28403918/trauma-and-endometriosis-a-review-may-we-explain-surgical-phenotypes-and-natural-history-of-the-disease
#6
M Canis, N Bourdel, C Houlle, A-S Gremeau, R Botchorishvili, S Matsuzaki
OBJECTIVE: The study was performed to evaluate whether trauma is an initial event of development of endometriosis. METHOD: Using Medline database from January 1960 up to December 2014, a systematic review was made of all published studies using the keywords trauma, healing, injury, infection, hyperperistaltism, stretch and endometriosis, adenomyosis and trauma. Studies and review articles written in French and/or in English related to the topic were included and reviewed independently by two authors...
March 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/28397981/a-randomized-trial-of-local-endometrial-injury-during-ovulation-induction-cycles
#7
RANDOMIZED CONTROLLED TRIAL
Medhat E E Helmy, Mohammad A Maher, Nabih I Elkhouly, Mahmoud Ramzy
OBJECTIVE: To investigate the effect of endometrial injury on pregnancy outcomes among infertile women taking clomifene citrate. METHODS: A prospective randomized trial was undertaken at an Egyptian hospital between January 26, 2015, and July 17, 2016. Eligible women (≥1 year primary/secondary/unexplained infertility, aged 20-35 years, day-2 follicle-stimulating hormone <12 IU/L, normal prolactin/thyroid function/uterine cavity, ≥1 patent tube, male partner with normal semen count and motility, 3 cycles of clomifene citrate without success) were randomly allocated (1:1) using computer-generated numbers into intervention (received endometrial injury on cycle day 15-24) or control groups (sham procedure)...
July 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28386815/endometrial-injury-the-quality-of-embryos-and-blastocyst-transfer-are-the-most-important-prognostic-factors-for-in-vitro-fertilization-success-after-previous-repeated-unsuccessful-attempts
#8
Milan Reljič, Jure Knez, Vilma Kovač, Borut Kovačič
PURPOSE: The purpose of this study was to find out the most important prognostic factors for achieving a pregnancy after in vitro fertilization (IVF) in women with history of repeated unsuccessful IVF attempts. METHODS: We analyzed factors affecting pregnancy rate in a retrospective study including 429 IVF/ICSI cycles performed in women younger than 40 years with at least three previous consecutive failed IVF/ICSI attempts. RESULTS: Clinical pregnancy was observed in 140/429 (32...
June 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28315625/endometrial-injury-for-women-with-previous-in-vitro-fertilization-failure-does-it-improve-pregnancy-rate
#9
REVIEW
Aleksandra Zygula, Iwona Szymusik, Barbara Grzechocinska, Piotr Marianowski, Miroslaw Wielgos
Implantation failure is one of the major factors limiting success of in vitro fertilization (IVF) treatment. According to ESHRE 2009 data only 32% of fresh embryo transfers resulted in clinical pregnancies. There are many ideas to improve the treatment outcomes, endometrial injury being one of them. It has been suggested that local endometrial injury, performed either by pipelle biopsy or hysteroscopy, may increase clinical pregnancy rate. However, up to date literature is widely disparate on that subject. There is no conclusion with regard to optimal timing, the number and technique of the procedure...
November 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28101111/a-randomized-trial-to-evaluate-the-effect-of-local-endometrial-injury-on-the-clinical-pregnancy-rate-of-frozen-embryo-transfer-cycles-in-patients-with-repeated-implantation-failure
#10
Ensieh Shahrokh-Tehraninejad, Minoo Dashti, Batool Hossein-Rashidi, Elham Azimi-Nekoo, Fedyeh Haghollahi, Vahid Kalantari
Objective: Repeated implantation failure (RIF) is a condition in which the embryos implantation decreases in the endometrium. So, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. Materials and methods: In this simple randomized clinical trial (RCT), a total of 120 patients were selected. The participants were less than 40 years old, and they are in their minimum two cycles of vitro fertilization (IVF). Patients were divided randomly into two groups of LEI (Local endometrial injury) and a control group (n = 60 in each group)...
September 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/27738660/does-intrauterine-saline-infusion-by-intrauterine-insemination-iui-catheter-as-endometrial-injury-during-ivf-cycles-improve-pregnancy-outcomes-among-patients-with-recurrent-implantation-failure-an-rct
#11
Saghar Salehpour, Marzieh Zamaniyan, Nasrin Saharkhiz, Shahrzad Zadeh Modares, Sedighe Hosieni, Samira Seif, Narges Malih, Parinaz Rezapoor, Mohammad-Reza Sohrabi
BACKGROUND: Recurrent implantation failure is one of the most issues in IVF cycles. Some researchers found that beneficial effects of endometrial Scratching in women with recurrent implantation failure, while some authors demonstrated contrary results. OBJECTIVE: The present study aimed to investigate the effect of intrauterine. Saline infusion as a form of endometrial injury, during fresh in vitro fertilization-embryo transfer cycle, among patients with recurrent implantation failure...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27525329/the-effect-of-endometrial-injury-on-pregnancy-rate-in-frozen-thawed-embryo-transfer-a-randomized-control-trial
#12
Abbas Aflatoonian, Ramesh Baradaran Bagheri, Robabe Hosseinisadat
BACKGROUND: Implantation failure is one of the most important factors limiting success in IVF treatment. The majority of trials have demonstrated favorable effect of endometrial injury on implantation success rate especially in women with recurrent implantation failure, while some studies failed to detect any benefit. OBJECTIVE: The purpose of our trial was to explore whether endometrial injury in luteal phase prior to frozen-thawed embryo transfer cycles would improve pregnancy outcomes? MATERIALS AND METHODS: We conducted a prospective controlled trial of 93 consecutive subjects at a research and clinical center for infertility...
July 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27363928/hysteroscopic-guided-local-endometrial-injury-does-not-improve-natural-cycle-pregnancy-rate-in-women-with-unexplained-infertility-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Tarek Shokeir, Mohamed Ebrahim, Hosam El-Mogy
AIM: To evaluate the efficacy of a hysteroscopic site-specific local endometrial injury (LEI) in a group of women with unexplained infertility (UI) undergoing expectant management with no fertility treatment versus no intervention. METHODS: This open-label, randomized controlled trial (RCT) was conducted between June 2013 and July 2015. Hysteroscopic site-specific LEI was determined by patient identification number, and 120 women were included. Eligible participants were randomly assigned to receive either a single, site-specific LEI guided by hysteroscopy (study group, n = 60) or no intervention (control group, n = 60)...
November 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/26908845/corroborating-evidence-for-platelet-induced-epithelial-mesenchymal-transition-and-fibroblast-to-myofibroblast-transdifferentiation-in-the-development-of-adenomyosis
#14
Xishi Liu, Minhong Shen, Qiuming Qi, Hongqi Zhang, Sun-Wei Guo
STUDY QUESTION: Do platelets play any role in the development of adenomyosis? SUMMARY ANSWER: As in endometriosis, adenomyotic lesions show significantly increased platelet aggregation, increased expression of transforming growth factor (TGF)-β1, phosphorylated Smad3, markers of epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transdifferentiation (FMT), and smooth muscle metaplasia (SMM), in conjunction with increased fibrosis as compared with normal endometrium...
April 2016: Human Reproduction
https://www.readbyqxmd.com/read/26890618/clinical-background-affecting-pregnancy-outcome-following-local-endometrial-injury-in-infertile-patients-with-repeated-implantation-failure
#15
Kotaro Kitaya, Hidehiko Matsubayashi, Yukiko Takaya, Rie Nishiyama, Kohei Yamaguchi, Tomomoto Ishikawa
Local endometrial injury (LEI) has been performed as a promising medical intervention to improve the pregnancy outcome in infertile women suffering from repeated implantation failure (RIF) in in vitro fertilization-embryo transfer cycles. The effect of LEI, however, remains controversial. The aim of this retrospective study was to identify the subgroups of patients with RIF who benefit from LEI. We compared the clinical parameters between the patients who had had a clinical pregnancy in the subsequent embryo transfer cycle following the LEI cycle (LEI-CP group, n = 94) and those who had resulted in negative pregnancy test (LEI-NP group, n = 114)...
July 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26360144/postoperative-survival-and-functional-outcomes-for-patients-with-metastatic-gynecological-cancer-to-the-spine-case-series-and-review-of-the-literature
#16
REVIEW
Ann Liu, Eric W Sankey, C Rory Goodwin, Thomas A Kosztowski, Benjamin D Elder, Ali Bydon, Timothy F Witham, Jean-Paul Wolinsky, Ziya L Gokaslan, Daniel M Sciubba
OBJECTIVE: Spinal metastases from gynecological cancers are rare, with few cases reported in the literature. In this study, the authors examine a series of patients with spinal metastases from gynecological cancer and review the literature. METHODS: The cases of 6 consecutive patients who underwent spine surgery for metastatic gynecological cancer between 2007 and 2012 at a single institution were retrospectively reviewed. The recorded demographic, operative, and postoperative factors were reviewed, and the functional outcomes were determined by change in Karnofsky Performance Scale and the American Spine Injury Association (ASIA) score during follow-up...
January 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/26054113/a-pilot-survey-on-obstetric-complications-in-pregnant-women-with-a-history-of-repeated-embryo-implantation-failure-and-those-undergoing-single-local-endometrial-injury
#17
Y Tada, K Kitaya, N Amano, M Kobatake, T Hayashi, S Taguchi, M Funabiki, Y Nakamura
PURPOSE OF INVESTIGATION: To assess if a history of repeated implantation failure (RIF) or local endometrial injury (LEI) for RIF affects the pregnancy course in women who conceived in the subsequent in vitro fertilization (IVF)-embryo/blastocyst transfer (ET/BT) cycle. MATERIALS AND METHODS: Of 42 pregnant women with a history of three consecutive failed ET/BT cycles with negative pregnancy tests, 11 patients had a clinical pregnancy in the immediate subsequent ET/BT cycle following (the RIF group), whereas 31 patients had a clinical pregnancy in the subsequent ET/BT cycle following single curettage LEI in the proliferative phase of the preceding spontaneous cycle (the RIF/LEI group)...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26001691/endometrial-ablation-in-the-management-of-abnormal-uterine-bleeding
#18
Philippe Laberge, Nicholas Leyland, Ally Murji, Claude Fortin, Paul Martyn, George Vilos, Nicholas Leyland, Wendy Wolfman, Catherine Allaire, Alaa Awadalla, Sheila Dunn, Mark Heywood, Madeleine Lemyre, Violaine Marcoux, Frank Potestio, David Rittenberg, Sukhbir Singh, Grace Yeung
BACKGROUND: Abnormal uterine bleeding (AUB) is the direct cause of a significant health care burden for women, their families, and society as a whole. Up to 30% of women will seek medical assistance for the problem during their reproductive years. OBJECTIVE: To provide current evidence-based guidelines on the techniques and technologies used in endometrial ablation (EA), a minimally invasive technique for the management of AUB of benign origin. METHODS: Members of the guideline committee were selected on the basis of individual expertise to represent a range of practical and academic experience in terms of both location in Canada and type of practice, as well as subspecialty expertise and general background in gynaecology...
April 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/25868581/morphological-changes-and-expression-of-cytokine-after-local-endometrial-injury-in-a-mouse-model
#19
Xiao-Hui Zhang, Zhao-Zhao Liu, Mao-Xing Tang, Yong-Hong Zhang, Lian Hu, Ai-Hua Liao
OBJECTIVE: To establish a mouse model for endometrial injury and determine the underlying mechanism regarding its favorable effect on embryo implantation. STUDY DESIGN: Female Kunming mice were randomly allocated into 4 groups: group I, normal control; group II, injury procedure control; and group III and group IV, the mice being scratched with a blunt syringe on the right uterine horn or both, respectively. All the mice were mated with the males during the next estrus phase...
November 2015: Reproductive Sciences
https://www.readbyqxmd.com/read/25469138/the-effects-of-endometrial-injury-on-intrauterine-insemination-outcome-a-randomized-clinical-trial
#20
Afsoon Zarei, Saeed Alborzi, Nasrin Dadras, Ghazal Azadi
BACKGROUND: Implantation is considered as the rate-limiting step in success of assisted reproduction techniques, and intrauterine insemination cycles. It might be affected by ovarian superovulation and endometrial local scratching. OBJECTIVE: This study aims to investigate the effect of local endometrial injury on the outcome of IUI cycles. MATERIALS AND METHODS: In this randomized clinical trial 144 women with unexplained infertility, mild male factor, and mild endometriosis randomly divided into two study groups through block randomization...
September 2014: Iranian Journal of Reproductive Medicine
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