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Local endometrial injury

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https://www.readbyqxmd.com/read/27738660/does-intrauterine-saline-infusion-by-intrauterine-insemination-iui-catheter-as-endometrial-injury-during-ivf-cycles-improve-pregnancy-outcomes-among-patients-with-recurrent-implantation-failure-an-rct
#1
Saghar Salehpour, Marzieh Zamaniyan, Nasrin Saharkhiz, Shahrzad Zadeh Modares, Sedighe Hosieni, Samira Seif, Narges Malih, Parinaz Rezapoor, Mohammad-Reza Sohrabi
BACKGROUND: Recurrent implantation failure is one of the most issues in IVF cycles. Some researchers found that beneficial effects of endometrial Scratching in women with recurrent implantation failure, while some authors demonstrated contrary results. OBJECTIVE: The present study aimed to investigate the effect of intrauterine. Saline infusion as a form of endometrial injury, during fresh in vitro fertilization-embryo transfer cycle, among patients with recurrent implantation failure...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27525329/the-effect-of-endometrial-injury-on-pregnancy-rate-in-frozen-thawed-embryo-transfer-a-randomized-control-trial
#2
Abbas Aflatoonian, Ramesh Baradaran Bagheri, Robabe Hosseinisadat
BACKGROUND: Implantation failure is one of the most important factors limiting success in IVF treatment. The majority of trials have demonstrated favorable effect of endometrial injury on implantation success rate especially in women with recurrent implantation failure, while some studies failed to detect any benefit. OBJECTIVE: The purpose of our trial was to explore whether endometrial injury in luteal phase prior to frozen-thawed embryo transfer cycles would improve pregnancy outcomes? MATERIALS AND METHODS: We conducted a prospective controlled trial of 93 consecutive subjects at a research and clinical center for infertility...
July 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27363928/hysteroscopic-guided-local-endometrial-injury-does-not-improve-natural-cycle-pregnancy-rate-in-women-with-unexplained-infertility-randomized-controlled-trial
#3
Tarek Shokeir, Mohamed Ebrahim, Hosam El-Mogy
AIM: To evaluate the efficacy of a hysteroscopic site-specific local endometrial injury (LEI) in a group of women with unexplained infertility (UI) undergoing expectant management with no fertility treatment versus no intervention. METHODS: This open-label, randomized controlled trial (RCT) was conducted between June 2013 and July 2015. Hysteroscopic site-specific LEI was determined by patient identification number, and 120 women were included. Eligible participants were randomly assigned to receive either a single, site-specific LEI guided by hysteroscopy (study group, n = 60) or no intervention (control group, n = 60)...
July 1, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/26908845/corroborating-evidence-for-platelet-induced-epithelial-mesenchymal-transition-and-fibroblast-to-myofibroblast-transdifferentiation-in-the-development-of-adenomyosis
#4
Xishi Liu, Minhong Shen, Qiuming Qi, Hongqi Zhang, Sun-Wei Guo
STUDY QUESTION: Do platelets play any role in the development of adenomyosis? SUMMARY ANSWER: As in endometriosis, adenomyotic lesions show significantly increased platelet aggregation, increased expression of transforming growth factor (TGF)-β1, phosphorylated Smad3, markers of epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transdifferentiation (FMT), and smooth muscle metaplasia (SMM), in conjunction with increased fibrosis as compared with normal endometrium...
April 2016: Human Reproduction
https://www.readbyqxmd.com/read/26890618/clinical-background-affecting-pregnancy-outcome-following-local-endometrial-injury-in-infertile-patients-with-repeated-implantation-failure
#5
Kotaro Kitaya, Hidehiko Matsubayashi, Yukiko Takaya, Rie Nishiyama, Kohei Yamaguchi, Tomomoto Ishikawa
Local endometrial injury (LEI) has been performed as a promising medical intervention to improve the pregnancy outcome in infertile women suffering from repeated implantation failure (RIF) in in vitro fertilization-embryo transfer cycles. The effect of LEI, however, remains controversial. The aim of this retrospective study was to identify the subgroups of patients with RIF who benefit from LEI. We compared the clinical parameters between the patients who had had a clinical pregnancy in the subsequent embryo transfer cycle following the LEI cycle (LEI-CP group, n = 94) and those who had resulted in negative pregnancy test (LEI-NP group, n = 114)...
July 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26360144/postoperative-survival-and-functional-outcomes-for-patients-with-metastatic-gynecological-cancer-to-the-spine-case-series-and-review-of-the-literature
#6
REVIEW
Ann Liu, Eric W Sankey, C Rory Goodwin, Thomas A Kosztowski, Benjamin D Elder, Ali Bydon, Timothy F Witham, Jean-Paul Wolinsky, Ziya L Gokaslan, Daniel M Sciubba
OBJECTIVE: Spinal metastases from gynecological cancers are rare, with few cases reported in the literature. In this study, the authors examine a series of patients with spinal metastases from gynecological cancer and review the literature. METHODS: The cases of 6 consecutive patients who underwent spine surgery for metastatic gynecological cancer between 2007 and 2012 at a single institution were retrospectively reviewed. The recorded demographic, operative, and postoperative factors were reviewed, and the functional outcomes were determined by change in Karnofsky Performance Scale and the American Spine Injury Association (ASIA) score during follow-up...
January 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/26054113/a-pilot-survey-on-obstetric-complications-in-pregnant-women-with-a-history-of-repeated-embryo-implantation-failure-and-those-undergoing-single-local-endometrial-injury
#7
Y Tada, K Kitaya, N Amano, M Kobatake, T Hayashi, S Taguchi, M Funabiki, Y Nakamura
PURPOSE OF INVESTIGATION: To assess if a history of repeated implantation failure (RIF) or local endometrial injury (LEI) for RIF affects the pregnancy course in women who conceived in the subsequent in vitro fertilization (IVF)-embryo/blastocyst transfer (ET/BT) cycle. MATERIALS AND METHODS: Of 42 pregnant women with a history of three consecutive failed ET/BT cycles with negative pregnancy tests, 11 patients had a clinical pregnancy in the immediate subsequent ET/BT cycle following (the RIF group), whereas 31 patients had a clinical pregnancy in the subsequent ET/BT cycle following single curettage LEI in the proliferative phase of the preceding spontaneous cycle (the RIF/LEI group)...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26001691/endometrial-ablation-in-the-management-of-abnormal-uterine-bleeding
#8
Philippe Laberge, Nicholas Leyland, Ally Murji, Claude Fortin, Paul Martyn, George Vilos, Nicholas Leyland, Wendy Wolfman, Catherine Allaire, Alaa Awadalla, Sheila Dunn, Mark Heywood, Madeleine Lemyre, Violaine Marcoux, Frank Potestio, David Rittenberg, Sukhbir Singh, Grace Yeung
BACKGROUND: Abnormal uterine bleeding (AUB) is the direct cause of a significant health care burden for women, their families, and society as a whole. Up to 30% of women will seek medical assistance for the problem during their reproductive years. OBJECTIVE: To provide current evidence-based guidelines on the techniques and technologies used in endometrial ablation (EA), a minimally invasive technique for the management of AUB of benign origin. METHODS: Members of the guideline committee were selected on the basis of individual expertise to represent a range of practical and academic experience in terms of both location in Canada and type of practice, as well as subspecialty expertise and general background in gynaecology...
April 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/25868581/morphological-changes-and-expression-of-cytokine-after-local-endometrial-injury-in-a-mouse-model
#9
Xiao-Hui Zhang, Zhao-Zhao Liu, Mao-Xing Tang, Yong-Hong Zhang, Lian Hu, Ai-Hua Liao
OBJECTIVE: To establish a mouse model for endometrial injury and determine the underlying mechanism regarding its favorable effect on embryo implantation. STUDY DESIGN: Female Kunming mice were randomly allocated into 4 groups: group I, normal control; group II, injury procedure control; and group III and group IV, the mice being scratched with a blunt syringe on the right uterine horn or both, respectively. All the mice were mated with the males during the next estrus phase...
November 2015: Reproductive Sciences
https://www.readbyqxmd.com/read/25469138/the-effects-of-endometrial-injury-on-intrauterine-insemination-outcome-a-randomized-clinical-trial
#10
Afsoon Zarei, Saeed Alborzi, Nasrin Dadras, Ghazal Azadi
BACKGROUND: Implantation is considered as the rate-limiting step in success of assisted reproduction techniques, and intrauterine insemination cycles. It might be affected by ovarian superovulation and endometrial local scratching. OBJECTIVE: This study aims to investigate the effect of local endometrial injury on the outcome of IUI cycles. MATERIALS AND METHODS: In this randomized clinical trial 144 women with unexplained infertility, mild male factor, and mild endometriosis randomly divided into two study groups through block randomization...
September 2014: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25349438/biopsy-induced-inflammatory-conditions-improve-endometrial-receptivity-the-mechanism-of-action
#11
Y Gnainsky, I Granot, P Aldo, A Barash, Y Or, G Mor, N Dekel
A decade ago, we first reported that endometrial biopsy significantly improves the success of pregnancy in IVF patients with recurrent implantation failure, an observation that was later confirmed by others. Recently, we have demonstrated that this treatment elevated the levels of endometrial pro-inflammatory cytokines and increased the abundance of macrophages (Mac) and dendritic cells (DCs). We therefore hypothesised that the biopsy-related successful pregnancy is secondary to an inflammatory response, and aimed at deciphering its mechanism of action...
January 2015: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/25246928/efficacy-of-the-local-endometrial-injury-in-patients-who-had-previous-failed-ivf-icsi-outcome
#12
Mustafa Kara, Turgut Aydin, Nurettin Turktekin, Karacavus S
BACKGROUND: The latest studies reported that local endometrial injury is a useful method to improve the success of IVF-ICSI outcome. OBJECTIVE: To assess whether local endometrial injury occurred by Pipelle in the spontaneous cycle could improve implantation rate, cleavage rate, and pregnancy outcome in the subsequent IVF-ICSI cycle in patients who had recurrent IVF failure. MATERIALS AND METHODS: An endometrial biopsy was performed on day 21(st) in 41 patients as intervention group in this retrospective cross-sectional study...
November 2012: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25155783/-evidence-based-medicine-and-high-performance-irradiation-techniques-endometrial-cancer
#13
E Jouglar, I Barillot
Radiation oncology is a field in which many technologic improvements have been made over the past decades. External beam radiotherapy has evolved from treatment fields planned on X-rays to 3-dimensional planning with fusion with MRI's and PET images. Recently, intensity-modulated radiotherapy has been tested for many cancer localizations, and its role in the treatment of gynecologic cancers is still under evaluation. Potential benefits are well known: decrease of treatment toxicity, improvement of efficacy through better dose delivery...
October 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/25064410/effect-of-local-endometrial-injury-on-pregnancy-outcomes-in-ovum-donation-cycles
#14
Lena Dain, Kamal Ojha, David Bider, Jacob Levron, Viktor Zinchenko, Sharon Walster, Martha Dirnfeld
OBJECTIVE: To evaluate the effect of local endometrial injury (LEI) on clinical outcomes in ovum donation recipients. DESIGN: Retrospective cohort analysis of ovum donation cycles conducted from 2005 to 2012. SETTING: Two private IVF centers. PATIENT(S): Total 737 ovum donation cycles. INTERVENTION(S): LEI by endometrial "scratch" with the use of a Pipelle catheter. MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth rates...
October 2014: Fertility and Sterility
https://www.readbyqxmd.com/read/24966392/role-of-uterine-contraction-in-regeneration-of-the-murine-postpartum-endometrium
#15
Asuka Yoshii, Shuji Kitahara, Hisashi Ueta, Kenjiro Matsuno, Taichi Ezaki
The endometrium undergoes continuous repair and regeneration without scarring throughout the reproductive life of women. However, the mechanisms responsible for this complete restoration remain mostly unexplored. We hypothesized that the ischemic state and local hypoxia present after parturition may create a special microenvironment for endometrial healing, and that this ischemia might be caused by reduction in organ volume via postpartum uterine contraction. Here, we developed a mouse model using a combination of cesarean section and the administration of a beta 2 adrenergic receptor agonist (ritodrine hydrochloride) in postpartum mice that had been ovariectomized to exclude the effect of ovarian hormones...
August 2014: Biology of Reproduction
https://www.readbyqxmd.com/read/24767648/long-term-survival-outcome-of-laparoscopic-staging-surgery-for-endometrial-cancer-in-taiwanese-experience
#16
Chyi-Long Lee, Kuan-Gen Huang, Pei-Ju Wu, Pei-Shan Lee, Chih-Feng Yen
OBJECTIVE: This study aims to evaluate the long-term safety and efficacy of laparoscopic staging surgery (LSS) for endometrial cancer in Taiwanese women. MATERIALS AND METHODS: This is a longitudinal study of prospectively registered 105 patients who underwent LSS for endometrial cancer between June 1995 and June 2008. RESULTS: The mean duration of surgery was 186.8 minutes, and the mean intraoperative blood loss was 220.38 mL. The median number of retrieved pelvic lymph nodes was 18...
March 2014: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/24639710/pregnancy-rate-after-endometrial-injury-in-couples-with-unexplained-infertility-a-randomized-clinical-trial
#17
Mohammad Ebrahim Parsanezhad, Nasrin Dadras, Najmeh Maharlouei, Leila Neghahban, Peghah Keramati, Madihe Amini
BACKGROUND: Unexplained infertility is still a challenging issue as to its causes, appropriate management and treatment. Evidence implicates early embryopathy or implantation failure as likely causes. OBJECTIVE: This study aims to investigate the effect of local endometrial injury on pregnancy rate in selected unexplained infertile patients. MATERIALS AND METHODS: This was a randomized clinical trial conducted in Shiraz University Infertility Clinic of Ghadir Hospital...
November 2013: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/24604231/potential-pathophysiological-mechanisms-of-the-beneficial-role-of-endometrial-injury-in-in-vitro-fertilization-outcome
#18
Charalampos Siristatidis, Nikos Vrachnis, Paraskevi Vogiatzi, Charalampos Chrelias, Andrea Quinteiro Retamar, Stefano Bettocchi, Demián Glujovsky
Successful embryo implantation is a complex process that involves multiple biological mechanisms and reciprocal interactions between the embryo and the proliferated endometrium. In this review, we provide an informative contribution on the pathways underlying the beneficial nature of endometrial injury toward improving implantation rates of embryos conceived and through in vitro fertilization. The evidence published to date are in favor of inducing local endometrial injury in the preceding cycle of ovarian stimulation to improve pregnancy outcomes in women with unexplained and recurrent implantation failure...
August 2014: Reproductive Sciences
https://www.readbyqxmd.com/read/24499747/image-guided-percutaneous-thermal-ablation-of-metastatic-pelvic-tumor-from-gynecologic-malignancies
#19
Selim R Butros, Marcela G DelCarmen, Raul N Uppot, Ronald S Arellano
BACKGROUND: Image-guided percutaneous thermal ablation is a commonly performed therapeutic procedure for various tumors. Thermal ablation is not frequently used in the pelvis as a result of anatomic concerns and the potential risk of nontarget tissue injury. TECHNIQUE: Percutaneous thermal ablation is a minimally invasive procedure involving special probes inserted through the skin to the target lesion under imaging guidance. Various delivery methods of thermal ablation exist, including radiofrequency ablation, which burns tissue, and cryoablation, which freezes tissue with an ultimate goal to destroy the target tumor while minimizing damage to adjacent structures...
March 2014: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/24411609/dosimetric-predictors-of-duodenal-toxicity-after-intensity-modulated-radiation-therapy-for-treatment-of-the-para-aortic-nodes-in-gynecologic-cancer
#20
Jonathan Verma, Erik P Sulman, Anuja Jhingran, Susan L Tucker, Gaiane M Rauch, Patricia J Eifel, Ann H Klopp
PURPOSE: To determine the incidence of duodenal toxicity in patients receiving intensity modulated radiation therapy (IMRT) for treatment of para-aortic nodes and to identify dosimetric parameters predictive of late duodenal toxicity. METHODS AND MATERIALS: We identified 105 eligible patients with gynecologic malignancies who were treated with IMRT for gross metastatic disease in the para-aortic nodes from January 1, 2005, through December 31, 2009. Patients were treated to a nodal clinical target volume to 45 to 50...
February 1, 2014: International Journal of Radiation Oncology, Biology, Physics
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