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JOURNAL ARTICLE
Iwona Scheliga, Dunja M Baston-Buest, Gereon Poschmann, Kai Stuehler, Jan-Steffen Kruessel, Alexandra P Bielfeld
Endometrial scratching (ES) has been widely used in assisted reproductive technology to possibly improve pregnancy rates, but its exact mechanism is still not understood or investigated, and its benefits are controversially discussed. Hypothetically, ES may trigger a local immune response, leading to an improved endometrial receptivity. So far, it has been shown that ES affects the gene expression of cytokines, growth factors, and adhesive proteins, potentially modulating inflammatory pathways and adhesion molecule expression...
September 1, 2023: International Journal of Molecular Sciences
#22
Xi Yang, Ke Ma, Rui Chen, Yi-Ting Meng, Jia Wen, Qiong-Qiong Zhang, Jie Zhu, Jing-Kun Yang, Xiu-Lian Zhao, Xin Huang, Lei Zhang, Tao Lv, Qinping Liao
OBJECTIVE: To evaluate the combination of transvaginal ultrasonography (TVS) and endometrial cytology test (ECT) as a potential diagnostic strategy for endometrial cancer and endometrial precancerous lesions in postmenopausal patients. METHODS: 570 postmenopausal patients admitted in our hospital due to abnormal bleeding or other symptoms and/or with endometrium thickness over 5 mm on ultrasound. The endometrial thickness was evaluated by TVS. Following obtainment with written consent, all patients underwent ECT, hysteroscopy and then dilatation and curettage (D&C)...
August 7, 2023: Journal of Gynecology Obstetrics and Human Reproduction
#23
JOURNAL ARTICLE
Faezeh Davoodi Asl, Seyedeh Saeideh Sahraei, Naser Kalhor, Hoda Fazaeli, Mohsen Sheykhhasan, Sanaz Soleimani Moud, Leila Naserpour, Azar Sheikholeslami
Endometriosis as a non-malignant gynecological disease leads to dysregulation of numerous cellular functions including apoptosis, angiogenesis, migration, proliferation, and inflammation. Accumulating evidence has shed light on the importance of endometrial stem cells within the menstrual blood which are involved in the establishment and progression of endometriotic lesions in a retrograde manner. According to the fact that the therapeutic benefits of mesenchymal stem cells are provided through paracrine functions, we used exosomes from menstrual blood-derived stem cells (MenSCs) for treating endometriotic stem cells to inhibit their lesion formation tendency...
September 2023: Reproductive Biology
#24
JOURNAL ARTICLE
Stefano Palomba, Domenico Carone, Amerigo Vitagliano, Flavia Costanzi, Alice Fracassi, Tiziana Russo, Serena Del Negro, Altiero Biello, Aldo Di Filippo, Antonio Mangiacasale, Antonio Monaco, Antonio Ranieri, Beatrice Ermini, Bruno Francesco Barba, Claudio Castello, Federica Di Guardo, Francesco Pastorella, Elena Bernasconi, Ezio Michele Tricarico, Francesca Filippi, Francesco Polsinelli, Giuseppe Lo Monte, Loredana M Sosa Fernandez, Marco Galletta, Paolo Giardina, Pasquale Totaro, Roberto Laganara, Roberto Liguori, Matteo Buccheri, Mario Montanino Oliva, Rosita Piscopo, Assunta Iuliano, Nicola Innantuoni, Irene Romanello, Francesco Sinatra, Annalisa Liprino, Roberto Thiella, Alessandra Tiezzi, Tiziana Bartolotti, Alessandra Tomasi, Valeria Finocchiaro, Mario Thiella, Giuseppa Fuggetta, Sebastiano Messineo, Francesco Isabella, Marcello Tripodi, Stefania Iaccarino, Giovanni Battista La Sala, Enrico Papaleo, Donatella Caserta, Roberto Marci, Edgardo Somigliana, Antonino Guglielmino
BACKGROUND: Endometrial scratching (ES) or injury is intentional damage to the endometrium performed to improve reproductive outcomes for infertile women desiring pregnancy. Moreover, recent systematic reviews with meta-analyses and randomized controlled trials demonstrated that ES is not effective, data on the safety are limited, and it should not be recommended in clinical practice. The aim of the current study was to assess the view and behavior towards ES among fertility specialists throughout infertility centers in Italy, and the relationship between these views and the attitudes towards the use of ES as an add-on in their commercial setting...
July 29, 2023: BMC Women's Health
#25
JOURNAL ARTICLE
Ahmed M Maged, Akmal El-Mazny, Yossra Lasheen, Noura El-Nassery
OBJECTIVE: This study aimed to evaluate the effect of endometrial scratch injury (ESI) in infertile women undergoing in vitro fertilization (IVF). METHODS: We screened MEDLINE, CENTRAL, EMBASE, Web of Science, and the Cochrane Central Register from inception to April 2023 using keywords related to endometrial scratch, implantation, infertility, and IVF. We included 41 randomized, controlled trials of ESI in IVF cycles (9084 women). The primary outcomes were the clinical pregnancy, ongoing pregnancy, and live birth rates...
July 2023: Journal of International Medical Research
#26
JOURNAL ARTICLE
Yan Pan, Jin Xi, Jing-Yu Liu, Jie Shen, Jie Cheng, You-Bing Xia
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the degree of endometrial fibrosis and inflammatory response in the rat model of intrauterine adhesion (IUA), so as to explore the possible mechanism of EA underlying improving IUA and promoting endometrium regeneration. METHODS: Forty-five female SD rats were randomly divided into blank, model and EA groups, with 15 rats in each group. The IUA model was established by mechanical scratching combined with lipopolysaccharide infection...
June 25, 2023: Zhen Ci Yan Jiu, Acupuncture Research
#27
JOURNAL ARTICLE
Nienke E van Hoogenhuijze, Gemma Lahoz Casarramona, Sarah Lensen, Cindy Farquhar, Mohan S Kamath, Aleyamma T Kunjummen, Nick Raine-Fenning, Sine Berntsen, Anja Pinborg, Shari Mackens, Zeynep Ozturk Inal, Ernest H Y Ng, Jennifer S M Mak, Sachin A Narvekar, Wellington P Martins, Mia Steengaard Olesen, Helen L Torrance, Ben W Mol, Marinus J C Eijkemans, Rui Wang, Frank J M Broekmans
BACKGROUND: In IVF/ICSI treatment, the process of embryo implantation is the success rate-limiting step. Endometrial scratching has been suggested to improve this process, but it is unclear if this procedure increases the chance of implantation and live birth (LB) and, if so, for whom, and how the scratch should be performed. OBJECTIVE AND RATIONALE: This individual participant data meta-analysis (IPD-MA) aims to answer the question of whether endometrial scratching in women undergoing IVF/ICSI influences the chance of a LB, and whether this effect is different in specific subgroups of women...
November 2, 2023: Human Reproduction Update
#28
JOURNAL ARTICLE
Xiangxiu Fan, Qi Zhao, Yuan Li, Ziyi Chen, Jingnan Liao, Huijun Chen, Fei Meng, Guang-Xiu Lu, Ge Lin, Fei Gong
BACKGROUND: Detailed knowledge of the changes in endometrial immune cells during the window of implantation in unexplained recurrent implantation failure (RIF) patients, the functions performed by immune cells, and the interactions between them is largely lacking. This study aimed to classify RIF patients and explore the mechanism through endometrial immune profiling and RNA-seq analysis. METHODS: This study enrolled a total of 172 patients, comprising 144 women with unexplained RIF and 28 fertile women...
June 17, 2023: International Immunopharmacology
#29
JOURNAL ARTICLE
L B P M Stevens Brentjens, D Obukhova, J E den Hartog, B Delvoux, J Koskivuori, S Auriola, M R Häkkinen, B Bui, N E van Hoogenhuijze, S Mackens, F Mol, J P de Bruin, D Besselink, G Teklenburg, V Kukushkina, A Salumets, F J M Broekmans, R J T van Golde, M Zamani Esteki, A Romano
OBJECTIVE: To study the relation between the steroid concentration in endometrium, in serum and the gene expression level of steroid metabolizing enzymes in the context of endometrial receptivity in IVF patients. DESIGN: Case-control study of 40 IVF patients recruited in the SCRaTCH study (NTR5342), a randomized controlled trial investigating pregnancy outcome after 'endometrial scratching'. Endometrial biopsies and serum were obtained from patients with a first failed IVF cycle randomized to the endometrial scratch in the mid-luteal phase of the natural cycle prior to the next fresh embryo transfer during the second IVF cycle...
May 2, 2023: F&S science
#30
JOURNAL ARTICLE
Stevan Cirkovic, Jack Wilkinson, Sarah Lensen, Emily Jackson, Joyce Harper, Katy Lindemann, Joan Costa-Font
There are conflicting narratives over what drives demand for add-ons. We undertook an online survey of IVF patients to determine whether patients perceive that use of IVF add-ons is driven by patients or practitioners. People who underwent IVF in the UK in the previous five years were recruited via social media Survey questions focussed on the roles of clinician offer and patient request, including who first suggested use of add-ons in IVF consultations, where patients first heard about them, and which information sources they trusted...
April 16, 2023: Human Fertility: Journal of the British Fertility Society
#31
JOURNAL ARTICLE
Yichao Tian, Jin Huang, Chi-Chiu Wang, Huizhen Lin, Xiaona Huang, Yue Zhao, Liu Liu, Songying Zhang
The value of endometrial scratch in women with recurrent embryo transfer has been controversial. Endometrial scratch is often performed in the mid-luteal phase of the cycle preceding embryo transfer but there is little scientific evidence if it affects the whole genome transcriptomic profile of peri-implantation endometrium in the following cycle. A prospective longitudinal cohort study was conducted in a university assisted reproductive unit. A total of eight women with recurrent implantation failure (RIF) were included...
April 8, 2023: Human Fertility: Journal of the British Fertility Society
#32
REVIEW
Awoniyi O Awonuga, Olivia G Camp, Husam M Abu-Soud, Daniel A Rappolee, Elizabeth E Puscheck, Michael P Diamond
Both uterine endometrium and embryo contribute to implantation success. However, their relative role in the implantation success is still a matter for debate, as are the roles of endometrial receptivity analysis (ERA), endometrial scratch (ES), endometrial microbiome, and intrauterine or intravenous measures that are currently advocated to improve the implantation success. There is insufficient evidence to suggest that the endometrium is more important than the embryo in determining the implantation success and the utility of these measures, especially when euploid embryos are transferred is limited...
March 29, 2023: Reproductive Sciences
#33
JOURNAL ARTICLE
Guan-Yu Ruan, Li-Xiang Ye, Jian-Song Lin, Hong-Yu Lin, Li-Rui Yu, Cheng-Yan Wang, Xiao-Dan Mao, Shui-Hua Zhang, Peng-Ming Sun
BACKGROUND: Endometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs against EC remains a key issue. Phytoestrogen kaempferol exhibits anti-cancer effects, but the action mechanisms are still unclear. METHOD: MTT assays, colony-forming assays, flow cytometry, scratch healing, and transwell assays were used to evaluate the proliferation, apoptosis, cell cycle, migration, and invasion of both ER-subtype EC cells...
March 17, 2023: Journal of Translational Medicine
#34
JOURNAL ARTICLE
Onder Celik, Arzu Yurci, Aynur Ersahin, Nur D Gungor, Nilufer Celik, Mustafa D Ozcil, Serdar Dogan, Semih Dalkilic, Lutfiye Dalkilic, Ulun Ulug, Sudenaz Celik, Andrea Tinelli
BACKGROUND: Homeobox genes A10 (HOXA10) and A11 (HOXA11), members of the abdominal B gene family, are responsible for embryonic survival and implantation. This study was planned to investigate whether endometrial injury alters the expression of both transcripts in women with implantation failure. METHODS: A total of 54 women with implantation failure were divided into two equal groups as experimental (scratching) and sham (no scratching). Participants in the scratching group were exposed to endometrial injury in the mid-luteal phase, and those in the sham group were exposed to endometrial flushing...
February 23, 2023: International Journal of Environmental Research and Public Health
#35
JOURNAL ARTICLE
Jie Li, Xueyao Li, Jinli Ding, Jing Zhao, Jiao Chen, Feng Guan, Haiyu Deng, Mengqi Zhou, Yiling Han, Zhuoni Xiao, Jing Yang
Chronic endometritis (CE) has been considered to reduce uterine receptivity and negatively affect reproductive outcomes for in vitro fertilization-embryo transfer (IVF-ET) patients, especially for people undergoing recurrent implantation failure (RIF). To investigate the effects of antibiotic and platelet-rich plasma (PRP) therapy on pregnancy outcomes following frozen-thawed embryo transfer (FET) in RIF patients with CE, endometrial specimens of 327 patients with RIF obtained by endometrial scratching during mid-luteal phase were immunostained by multiple myeloma oncogene-1 (Mum-1)/syndecan-1 (CD138)...
2023: Frontiers in Cell and Developmental Biology
#36
JOURNAL ARTICLE
Joji Ueno, Renato De Mayrinck Salgado, Dani Ejzenberg, Filomena Marília Henriques Carvalho, Eduardo Carvalho de Arruda Veiga, José Maria Soares Júnior, Edmund Chada Baracat
OBJECTIVE: This study sought to evaluate the influence of time (early <90 days and late >90 days) and endometrial injury on pregnancy success. METHODS: This is a retrospective study in which all infertile women who underwent at least one in vitro fertilization cycle at Clinica Gera between 2010 and 2015 were considered for inclusion. We included patients with a normal ovarian reserve and regular menses at intervals of up to 30 days. A total of 315 patient files were reviewed, and the study group was composed of patients who faced fertility issues and had male-caused infertility or idiopathic infertility...
2023: Revista da Associação Médica Brasileira
#37
Emilio Blum-Panchana, Nicolas Gallardo-Molina, Bernardo Blum-Pinto, Medardo Blum-Narváez, Xavier Blum-Rojas, Tatiana Puga-Torres
Hormonal treatment as endometrial preparation for frozen-thawed embryo transfer (FET) is routinely carried out with oral, transdermal or combined estradiol supplementation; however, in some cases, there is no optimal endometrial development with this type of stimulation. In this case report, our patient failed to respond to conventional endometrial preparation techniques. For this reason, two unconventional techniques were combined to improve endometrial receptivity; endometrial injury, followed by rFSH administration...
September 12, 2023: JBRA Assisted Reproduction
#38
RANDOMIZED CONTROLLED TRIAL
Mohammad M A Ahmed, Asmaa Nafady, Sayed A M Taha, Ahmed M G El-Din, Abd El-Naser Abd El-Gaber Ali
BACKGROUND: Uterine receptivity and implantation are complex processes requiring coordinated expression of molecules by zygote and uterus. Leukemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Our objectives were to measure the leukemia inhibitory factor (LIF) concentration in serum with or without endometrial scratch-ing in women with unexplained infertility...
December 1, 2022: Clinical Laboratory
#39
JOURNAL ARTICLE
Xiao-Li Li, Xiu-Xiu Zhang, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Carlos L Cespedes-Acuña, Jian-Guo Zhang, Zhao-Jun Wei
ETHNOPHARMACOLOGICAL RELEVANCE: Polygonatum sibiricum Redouté (PS, also called Huangjing in traditional Chinese medicine), is a perennial herb as homology of medicine and food. According to the traditional Chinese medicine theory "Special Records of Famous Doctors", its functions include invigorating qi and nourishing yin, tonifying spleen and kidney. Traditionally, qi and blood therapy has been believed as most applicable to the treatment of uterine disease. The current research has focused on the effect and mechanism of dioscin, the main active component of PS, on Endometrial carcinoma (EC)...
December 8, 2022: Journal of Ethnopharmacology
#40
REVIEW
Stefano Palomba, Amerigo Vitagliano, Roberto Marci, Donatella Caserta
Endometrial scratching is intentional injury of the endometrium intended to improve the reproductive outcomes of infertile women who seek pregnancy. In recent years, several randomized controlled trials, systematic reviews, and meta-analyses of trials have been published, reporting controversial results. Some authors have recommended against endometrial scratching in clinical practice, while others have recommended its application to specific categories of patients. This article aimed to provide a critical analysis of the old and new available evidence, to assist physicians interpreting the published data, and to generate insights for future research on the topic...
June 2023: Reproductive Sciences
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