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https://www.readbyqxmd.com/read/29243298/local-anesthesia-in-pediatric-dermatologic-surgery-evaluation-of-a-patient-centered-approach
#1
May El Hachem, Claudia Carnevale, Andrea Diociaiuti, Cristiana De Ranieri, Simona Giancristoforo, Giovanna Zambruno, Marta L Ciofi Degli Atti
BACKGROUND/OBJECTIVES: A few studies have documented the effect of local anesthesia for minor dermatologic surgical procedures on children and their parents. Our objective was to evaluate the psychological effect and global satisfaction of a patient-centered approach to dermatologic surgery under local anesthesia. METHODS: Two self-administered questionnaires were used to evaluate the distress and global satisfaction of 388 children who underwent dermatologic surgery under local anesthesia, accompanied by oral and written therapeutic education measures (structured information and a cartoon brochure illustrating the procedure) addressed to children and parents...
December 15, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29243176/understanding-and-reducing-complex-systems-pharmacology-models-based-on-a-novel-input-response-index
#2
Jane Knöchel, Charlotte Kloft, Wilhelm Huisinga
A growing understanding of complex processes in biology has led to large-scale mechanistic models of pharmacologically relevant processes. These models are increasingly used to study the response of the system to a given input or stimulus, e.g., after drug administration. Understanding the input-response relationship, however, is often a challenging task due to the complexity of the interactions between its constituents as well as the size of the models. An approach that quantifies the importance of the different constituents for a given input-output relationship and allows to reduce the dynamics to its essential features is therefore highly desirable...
December 14, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29242796/bilateral-femoral-neck-fractures-in-cerebrotendinous-xanthomatosis-treated-by-hip-arthroplasties-the-first-case-report-and-literature-review
#3
Witchuree Wejjakul, Swist Chatmaitri, Thongek Wattanarojanaporn, Anuwat Pongkunakorn, Chupong Ittiwut, Vorasuk Shotelersuk
Introduction: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disease caused by mutations of the CYP27A1 gene and deficiency of the sterol-27-hydroxylase enzyme in bile acid biosynthesis. It is characterized by the accumulation of cholestanol and bile alcohols in plasma, the formation of xanthomatous lesions in various tissues, and organ degeneration. This disorder is also associated with osteoporosis and increased risk of fracture. To date, only two CTX patients with femoral neck fractures have been reported...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242096/risk-factors-for-short-term-complications-after-rotator-cuff-repair-in-the-united-states
#4
William W Schairer, Benedict U Nwachukwu, Michael C Fu, Russell F Warren
PURPOSE: To use a population-level dataset to evaluate the rate of 30-day complications after rotator cuff repair, and to evaluate the risk factors for complication and unplanned hospital readmission. METHODS: We used the American College of Surgeons National Surgical Quality Improvement Program from 2011 to 2015 to identify patients who underwent rotator cuff repair and concomitant procedures using Current Procedural Terminology codes. Postoperative complications and unplanned hospital readmissions were identified...
December 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29241841/dorsal-wrist-plication-for-midcarpal-instability
#5
Herbert P von Schroeder
PURPOSE: Midcarpal instability (MCI) is a cause of chronic wrist pain for which treatment remains controversial. This study's purpose was to determine the outcome of a treatment algorithm for MCI that included immobilization and surgical interventions. METHODS: We prospectively enrolled 23 consecutive patients (12 males, average age 27 years) with 27 symptomatic wrists. All had generalized wrist pain with an average duration of 22 months. All had MCI and a catch-up clunk that reproduced the symptoms...
December 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29239902/oath-taking-at-u-s-and-canadian-medical-school-ceremonies-historical-perspectives-current-practices-and-future-considerations
#6
Steven J Scheinman, Patrick Fleming, Kellyann Niotis
The widespread use of oaths at medical commencements is a recent phenomenon of the late 20th century. While many are referred to as "Hippocratic," surveys have found that most oaths are modern, and the use of unique oaths has been rising. Oaths taken upon entry to medical school are even more recent, and their content has not been reported. The authors surveyed all Association of American Medical Colleges member schools in the United States and Canada in 2015 and analyzed oath texts. Of 111 (70.2%) responses, full texts were submitted for 80 commencement and 72 white coat oaths...
December 12, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29239476/complications-associated-with-surgical-dehorning-in-goats-a-retrospective-study-of-239-cases
#7
Amanda K Hartnack, Molly E Jordan, Allen J Roussel
OBJECTIVE: This article describes complications following surgical dehorning of goats. STUDY DESIGN: Retrospective. Medical records of goats that underwent surgical dehorning were reviewed. ANIMALS: Two hundred thirty-nine goats. METHODS: The medical records of 239 goats, not previously dehorned by other methods, that were cosmetically dehorned between January 2006 and April 2016, were reviewed. Data retrieved from the medical records included breed, weight, the surgeon performing the procedure, intraoperative complications, and the occurrence of return visits to the teaching hospital because of complications related to the dehorning procedure...
December 14, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29238363/bleeding-outcomes-after-non-emergency-percutaneous-coronary-intervention-in-the-very-elderly
#8
Vimalraj Bogana Shanmugam, Dennis T Wong, Hashrul Rashid, James D Cameron, Yuvaraj Malaiapan, Peter J Psaltis
Background: Octogenarians constitute an increasing proportion of patients presenting for non-emergency percutaneous coronary intervention (PCI). Methods: This study evaluated the in-hospital procedural characteristics and outcomes, including the bleeding events of 293 octogenarians presenting between January 2010 and December 2012 for non-emergency PCI to a single large volume tertiary care Australian center. Comparisons were made with 293 consecutive patients aged less than or equal to 60 years, whose lesions were matched with the octogenarians...
October 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29237688/heritability-of-atrial-fibrillation
#9
Lu-Chen Weng, Seung Hoan Choi, Derek Klarin, J Gustav Smith, Po-Ru Loh, Mark Chaffin, Carolina Roselli, Olivia L Hulme, Kathryn L Lunetta, Josée Dupuis, Emelia J Benjamin, Christopher Newton-Cheh, Sekar Kathiresan, Patrick T Ellinor, Steven A Lubitz
BACKGROUND: Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. METHODS AND RESULTS: We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2g ) using data from 120 286 unrelated individuals of European ancestry (2987 with AF) in the population-based UK Biobank...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29237427/clinical-applications-and-effectiveness-of-guided-implant-surgery-a-critical-review-based-on-randomized-controlled-trials
#10
Marco Colombo, Carlo Mangano, Eitan Mijiritsky, Mischa Krebs, Uli Hauschild, Thomas Fortin
BACKGROUND: Nowadays implant placement protocols are widespread among clinicians all over the world. However, available literature, only partially analyses what can be potential benefits for the clinicians and patients, often focusing just on specific aspects, such as accuracy. The purpose of this review is to compare computer guided implant placement with conventional treatment protocols. METHODS: A search strategy according to the P-I-C-O format was developed and executed using an electronic MEDLINE plus manual search from 2000 up to December 2016...
December 13, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29237411/periprocedural-heparin-bridging-in-patients-receiving-oral-anticoagulation-a-systematic-review-and-meta-analysis
#11
Jing Wen Yong, Li Xia Yang, Bright Eric Ohene, Yu Jie Zhou, Zhi Jian Wang
BACKGROUND: Periprocedural heparin bridging therapy aims to reduce the risk of thromboembolic events in patients requiring an interruption in their anticoagulation therapy for the purpose of an elective procedure. The efficacy and safety of heparin bridging therapy has not been well established. OBJECTIVES: To compare through meta-analysis the effects of heparin bridging therapy on the risk of major bleeding and thromboembolic events of clinical significance among patients taking oral anticoagulants...
December 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29237360/endovascular-treatment-of-thromboangiitis-obliterans-buerger-s-disease
#12
Mohammad-Hadi S Modaghegh, Shahab Hafezi
PURPOSE: When critical limb ischemia (CLI) occurs in patients with thromboangiitis obliterans (TAO) or Buerger's disease, smoking cessation alone may be insufficient to relieve rest pain and promote wound healing. Accordingly, adjunctive measures are warranted to restore adequate blood flow required for limb salvage. This study aimed to evaluate the feasibility and efficacy of percutaneous transluminal angioplasty (PTA) for the treatment of patients with TAO and CLI. In addition, a review of the literature on endovascular management of TAO is included...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29237147/treatment-of-early-stage-extracranial-arteriovenous-malformations-with-intralesional-interstitial-bleomycin-injection-a-pilot-study
#13
Yunbo Jin, Yun Zou, Chen Hua, Hui Chen, Xi Yang, Gang Ma, Lei Chang, Yajing Qiu, Dongze Lyu, Tianyou Wang, Shih-Jen Chang, Congzhen Qiao, Chunfen Luo, Mathias Tremp, Xiaoxi Lin
Purpose To assess the efficacy and safety of intralesional interstitial bleomycin injection in the treatment of early-stage (Schobinger stage I or II) extracranial arteriovenous malformations (AVMs). Materials and Methods This prospective study involved 34 patients with early-stage AVMs, as defined by the Schobinger staging system. The patients received intralesional interstitial bleomycin injected at a maximum dose of 15 000 IU or 1000 IU per kilogram of body weight for children who weighed less than 15 kg per procedure for a total of 6 months (once every month)...
December 13, 2017: Radiology
https://www.readbyqxmd.com/read/29235350/spatial-confinement-of-the-optical-sensitizer-to-realize-thin-film-organic-photodetector-with-high-detectivity-and-thermal-stability
#14
Min Su Jang, Seongwon Yoon, Kyu Min Sim, Jangwhan Cho, Dae Sung Chung
A thin film planar heterojunction organic photodetector (PHJ-OPD) is demonstrated. Different from a conventional sensitizer-doped photodetector, the limited spatial distribution of sensitizer in a PHJ-OPD enables significantly reduced thickness of the active layer without allowing the formation of unnecessary trap sites and electron percolation pathways. As a result, peak external quantum efficiency (EQE) of 120,700% and detectivity over 1013 Jones are demonstrated with thin active layer thickness of 150 nm, which can be a significant benefit for high resolution image sensor application...
December 13, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29235093/role-of-clinical-and-laboratory-parameters-for-treatment-choice-in-patients-with-inherited-fvii-deficiency-undergoing-surgical-procedures-evidence-from-the-ster-registry
#15
Matteo N D Di Minno, Mariasanta Napolitano, Alberto Dolce, Guglielmo Mariani
Perioperative bleeding is a major concern in patients with factor VII (FVII) deficiency. Evaluating data of 95 FVII-deficient patients undergoing 110 surgical procedures (61 major, 49 minor), we assessed the impact of type of surgery, bleeding phenotype and FVII coagulant activity (FVII:C) levels on perioperative replacement therapy (RT). Compared to those with higher FVII:C levels, patients with <3% FVII:C received a higher number of RT doses (8 vs. 2, P = 0·003) for a longer RT duration (3 days vs...
December 12, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29234971/elective-ambulatory-surgical-care-in-ireland-why-it-needs-to-be-better-coded-classified-and-managed
#16
Frank Keane, Laura Hammond, Gerry Kelliher, Ken Mealy
BACKGROUND: In the year to July 2017, surgical disciplines accounted for 73% of the total national inpatient and day case waiting list and, of these, day cases accounted for 72%. Their proper classification is therefore important so that patients can be managed and treated in the most suitable and efficient setting. AIMS: We set out to sub-classify the different elective surgical day cases treated in Irish public hospitals in order to assess their need to be managed as day cases and the consistency of practice between hospitals...
December 12, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29234925/modelling-the-effects-of-psii-inhibitor-pulse-exposure-on-two-algae-in-co-culture
#17
Pierre-Jean Copin, Nathalie Chèvre
A weakness of standard testing procedures is that they do not consider interactions between organisms, and they focus only on single species. Furthermore, these procedures do not take into account pulse exposure. However, pulse exposure is of particular importance because in streams, after crop application and during and after precipitation, herbicide concentrations fluctuate widely and can exceed the Annual Average Environmental Quality Standards (AA-EQS), which aim to protect the aquatic environment. The sensitivity of the algae Scenedesmus vacuolatus and Pseudokirchneriella subcapitata in a co-culture exposed to pulses is thus analysed in this study...
December 12, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/29234836/trans-urethral-ureteral-stent-replacement-technique-trust-10-year-experience-in-1168-patients
#18
Gianpaolo Carrafiello, Andrea Coppola, Giuseppe De Marchi, Federico Fontana, Filippo Piacentino, Mario Petrillo, Alessandro Taborelli, Salvatore Alessio Angileri, Genti Xhepa, Nicola Macchione, Alessandro Bacuzzi, Alberto Marconi, Anna Maria Ierardi
OBJECTIVES: To affirm technical success, clinical success and safety of fluoroscopically guided transurethral replacement of double-J (DJ) ureteral stents. METHODS: From January 2005 to December 2015, in a follow-up period ranging from 9 to 73 months, we replaced 6167 DJ ureteral stents in 3221 procedures in 1168 patients. All the procedures were performed in the angiography suite under fluoroscopic control. RESULTS: Technical success was achieved in 97...
December 12, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29234193/results-of-portosystemic-shunt-embolization-in-selected-patients-with-cirrhosis-and-recurrent-hepatic-encephalopathy
#19
Narendra S Choudhary, Sanjay Saran Baijal, Sanjiv Saigal, Amit Agarwal, Neeraj Saraf, Rohit Khandelwal, Vaibhav Jain, Anubhav Harish Khandelwal, Abhay Kapoor, Deepak Jain, Smurti R Misra, Rajesh Puri, Randhir Sud, Arvinder S Soin
Background: Large portosystemic shunts (PSSs) may lead to recurrent encephalopathy in patients with cirrhosis and embolization of these shunts may improve encephalopathy. Material and methods: Five patients underwent balloon-occluded retrograde transvenous obliteration (BRTO) or plug-assisted retrograde transvenous obliteration (PARTO) of a large PSS at our center in last 2 years for recurrent hepatic encephalopathy (HE) at a tertiary care center at north India...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234133/multi-channel-microfluidic-chip-coupling-with-mass-spectrometry-for-simultaneous-electro-sprays-and-extraction
#20
Cilong Yu, Fei Tang, Xiang Qian, Yan Chen, Quan Yu, Kai Ni, Xiaohao Wang
Considering the advantages and research status of microfluidic chip coupling with mass spectrometry (MS), a microfluidic chip-based multi-channel ionization (MCMCI) for the extraction of untreated compounds in complex matrices without sample pretreatments was developed. Quantitative analysis of human urine spiked with various rhodamine B concentrations was also performed, and good linearity was obtained. Comparing to the macro ionization device, MCMCI significantly improved the integration of ionization source, simplified the operation of such a device, and greatly increased the signal intensity with much lower gas pressure...
December 12, 2017: Scientific Reports
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