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https://www.readbyqxmd.com/read/28637008/cytotoxic-profiling-of-artesunic-and-betulinic-acids-and-their-synthetic-hybrid-compound-on-neurons-and-gliomas
#1
Annemarie Ackermann, Aysun Çapcı Karagöz, Ali Ghoochani, Michael Buchfelder, Ilker Eyüpoglu, Svetlana B Tsogoeva, Nicolai Savaskan
Gliomas are brain-born tumors with devastating impact on their brain microenvironment. Novel approaches employ multiple combinations of chemical compounds in synthetic hybrid molecules to target malignant tumors. Here, we report on the chemical hybridization approach exemplified by artesunic acid (ARTA) and naturally occurring triterpene betulinic acid (BETA). Artemisinin derived semisynthetic compound artesunic acid (ARTA) and naturally occurring triterpene BETA were used to synthetically couple to the hybrid compound termed 212A...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636658/efficacy-and-safety-of-ultrasound-guided-implantation-of-fiducial-markers-in-the-liver-for-stereotactic-body-radiation-therapy
#2
So Hyun Park, Hyung Jin Won, So Yeon Kim, Yong Moon Shin, Pyo Nyun Kim, Sang Min Yoon, Jin-Hong Park, Jong Hoon Kim
OBJECTIVE: Stereotactic body radiation therapy (SBRT) for the treatment of a malignancy in the liver requires the perilesional implantation of fiducial markers for lesion detection. The purpose of this study is to evaluate the efficacy and safety of ultrasound (US) -guided marker implantation for SBRT. METHODS: We retrospectively reviewed 299, US-guided, intrahepatic fiducial markers implanted in 101 patients between November 2013 and September 2014. SBRT-planning CT images were analyzed to determine the technical success of the implantation, the mean distance between the tumor margin and the marker, with the ideal location of fiducials defined as the distance between a marker and a tumor less than 3 cm and the distance between markers greater than 2 cm according to the tumor conspicuity seen on gray-scale US and the artifact obscuring tumor margins...
2017: PloS One
https://www.readbyqxmd.com/read/28633619/the-affect-misattribution-procedure
#3
Sarah Teige-Mocigemba, Manuel Becker, Jeffrey W Sherman, Regina Reichardt, Karl Christoph Klauer
The Affect Misattribution Procedure (AMP) has been forwarded as one of the most promising alternatives to the Implicit Association Test and the evaluative-priming task for measuring attitudes such as prejudice indirectly. We investigated whether the AMP is indeed able to detect an evaluative out-group bias. In contrast to recent conclusions about the robustness of AMP effects, six out of seven pilot studies indicated that participants did not show any prejudice effects in the AMP. Yet, these pilot studies were not fully conclusive with regard to our research question because they investigated different domains of prejudice, used small sample sizes, and employed a modified AMP version...
May 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28633065/differential-accumulation-of-pahs-elements-and-pb-isotopes-by-five-lichen-species-from-the-athabasca-oil-sands-region-in-alberta-canada
#4
Joseph R Graney, Matthew S Landis, Keith J Puckett, William B Studabaker, Eric S Edgerton, Allan H Legge, Kevin E Percy
A 2014 case study investigated the relative accumulation efficiency of polycyclic aromatic hydrocarbons (PAHs), total sulfur (S), total nitrogen (N), major and minor elements and Pb isotopes in five common lichen species at three boreal forest sites in the Athabasca Oil Sands Region (AOSR) in northeastern Alberta, Canada to identify the optimum lichen species for future biomonitoring. Differences in concentrations of PAHs, multiple elements, and Pb isotopes in fruticose (Bryoria furcellata, Cladina mitis, Evernia mesomorpha) and foliose (Hypogymnia physodes and Tuckermannopsis americana) lichens were found along a 100 km distance gradient from the primary oil sands operations...
June 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28632578/acute-abdominal-pain-recognition-and-management-of-constipation-in-the-emergency-department
#5
Stefania Norbedo, Giulia Bassanese, Francesca Barbieri, Egidio Barbi
OBJECTIVE: The main aim of the study was to investigate the incidence and the clinically relevant features of functional constipation in patients evaluated for acute abdominal pain in a tertiary care pediatric emergency department. METHODS: This is a retrospective study. We analyzed 4394 medical records and recorded the information (demographics, triage code, symptoms, medical history, physical evaluation, laboratory tests, radiological studies, procedures, and treatments) of all patients admitted for acute abdominal pain to the emergency department of the IRCCS Burlo Garofolo, Trieste, during 2010 to 2013...
June 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28631863/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-safe-as-it-sounds
#6
REVIEW
Preyas J Vaidya, Mohammed Munavvar, Joerg D Leuppi, Atul C Mehta, Prashant N Chhajed
Real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has earned its place as a standard of care in the evaluation of mediastinal and hilar lymphadenopathy. It is a minimally invasive and a safe procedure with high diagnostic accuracy and efficacy. The increased usage of EBUS-TBNA worldwide has thrown light on its possible complications including death. The complications range from minor to life threatening in few and may occur either early or later in the course after the procedure...
June 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28630716/femoral-neck-fractures-as-a-complication-of-hip-arthroscopy-a-systematic-review
#7
REVIEW
Nolan S Horner, Khanduja Vikas, Austin E MacDonald, Jan-Hendrik Naendrup, Nicole Simunovic, Olufemi R Ayeni
The purpose of this study was to identify the causes and risk factors for hip fractures, a rare but devastating complication, following hip arthroscopy. The electronic databases MEDLINE, EMBASE and PubMed were searched and screened in duplicate for relevant clinical and basic sciences studies and pertinent data was abstracted and analysed in Microsoft Excel. Nineteen studies (12 clinical studies and seven biomechanical studies) with a total of 31 392 patients experiencing 43 hip fractures (0.1% of patients) met the inclusion criteria for this systematic review...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28629904/perioperative-morbidity-of-same-day-and-staged-bilateral-total-hip-arthroplasty
#8
Lazaros A Poultsides, Georgios K Triantafyllopoulos, Stavros G Memtsoudis, Huong T Do, Michael M Alexiades, Thomas P Sculco
BACKGROUND: Management strategies for bilateral hip degenerative disease include same-day or staged bilateral total hip arthroplasty (THA), but information on outcomes remains sparse. We sought to describe in-hospital complications and blood transfusion rates after same-day and staged bilateral THAs at different time intervals and to assess risk factors for these events. METHODS: We retrospectively reviewed administrative data for 3785 patients treated with same-day bilateral (n = 1946; group A) and staged bilateral THA within (1) 0-3 months apart (n = 328; group B); (2) 3-6 months apart (n = 703; group C); and (3) 6-12 months apart (n = 808; group D), between 1999 and 2014...
May 23, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28629305/evaluation-of-cost-and-length-of-stay-linked-to-complications-associated-with-major-surgical-procedures
#9
M Pirson, F Dehanne, J Van den Bulcke, P Leclercq, D Martins, A De Wever
INTRODUCTION: A lot of studies have demonstrated the possibility of reducing the number of post-operative complications in the domain of major surgical procedures with the use of medical preventive techniques. However, complications following surgical procedures are unfortunately frequent and are a major problem, not only because of the impact for the patient, but also because of economic consequences that they provoke. The aim of the present study is to evaluate the extra length of stay and the extra cost, born by the hospital and the social security, linked to complications, incurring after major surgical procedures...
June 19, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28628973/a-baseline-survey-of-dissolved-methane-in-aquifers-of-great-britain
#10
R A Bell, W G Darling, R S Ward, L Basava-Reddi, L Halwa, K Manamsa, B E Ó Dochartaigh
Interest in dissolved methane (CH4) concentrations in aquifers in England, Scotland and Wales ('Great Britain' or GB) has grown concurrently with interest in the exploitation of unconventional gas sources (UGS). Experience, mainly from North America, has shown the importance of a pre-production baseline against which changes possibly due to UGS extraction can be compared. The British Geological Survey, aided by water utilities, private users and regulators, has compiled a unique dataset for CH4 in groundwaters of GB...
June 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28627398/stones-first-a-gas-pyelo-nephroscopy-strategy-for-laparoscopic-pyeloplasty-and-renal-stone-extraction
#11
C Kouriefs, F Georgiades, P Grange
OBJECTIVE: To report our experience on gas endoscopy as the first step of pelvi-ureteric junction (PUJ) obstruction repair when complicated by nephrolithiasis. MATERIALS AND METHODS: Stone formation due to urine stasis is a known complication PUJ obstruction and an indication for its surgical repair. The undisputed results of the Anderson-Hynes dismembered pyeloplasty make it a quasi-gold standard; however, the identification and extraction of calyceal stones through the laparoscopic route can be challenging...
June 13, 2017: Urology
https://www.readbyqxmd.com/read/28625512/first-experience-with-edoxaban-and-atrial-fibrillation-ablation-insights-from-the-engage-af-timi-48-trial
#12
Jan Steffel, Christian T Ruff, Rose A Hamershock, Sabina A Murphy, Roxy Senior, Denis Roy, Hans-Joachim Lanz, Michele F Mercuri, Elliott M Antman, Robert P Giugliano
BACKGROUND: Atrial fibrillation (AF) ablation procedures are increasingly being performed in patients receiving direct oral anticoagulants (DOACs). Experience regarding the safety of edoxaban in this context is limited. In an exploratory analysis we therefore investigated the outcome of patients undergoing transcatheter AF ablation in the ENGAGE AF-TIMI 48 trial. METHODS & RESULTS: During the trial, 193 transcatheter AF ablation procedures were performed in 169 patients...
June 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28625010/treatment-of-tongue-base-masses-in-children-by-transoral-robotic-surgery
#13
Fatma Tulin Kayhan, Ayse Pelin Yigider, Arzu Karaman Koc, Kamil Hakan Kaya, Ibrahim Erdim
The feasibility and effectiveness of transoral robotic surgery (TORS) in children with tongue base masses (TBMs) were evaluated. Eight pediatric patients who were treated with TORS for TBMs between January 2010 and January 2016 at a tertiary hospital included in the study. All pathologies were congenital lesions: four were lingual thyroglossal ductus cysts (LTGDCs), one was a minor salivary gland tumor, one was a vallecular cyst, one was a bronchogenic cyst, and one was an ectopic thyroid tissue. TORS was performed successfully in all cases...
June 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28624926/limited-awareness-of-animal-influenza-prevention-and-control-among-dai-lue-smallholder-farmers-in-southwest-china
#14
Xiang Zhao, Gareth Davey
Awareness of animal influenza and its prevention and control is important for ensuring livestock health, production and welfare. In China, a country stereotyped as a major source of emerging zoonotic infectious diseases, research on the public understanding of animal influenza is limited to the Han, the main ethnic group. The present qualitative study in Southwest China investigated awareness of animal influenza among the Dai, an ethnic minority. The participants (15 men and 10 women, ages 18-83) were smallholder farmers of pigs and poultry in rural areas of Jinghong, Xishuangbanna, Yunnan Province...
June 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28623988/rivaroxaban-for-thrombosis-prophylaxis-in-endovenous-laser-ablation-with-and-without-phlebectomy
#15
Heiko Uthoff, Daniel Holtz, Pavel Broz, Daniel Staub, Luca Spinedi
OBJECTIVE: Endovenous heat-induced thrombosis (EHIT) is a well-described complication of endovenous laser ablation (EVLA). We report our centers' experience on the efficacy (EHIT level ≥2 according to the Kabnick classification) and safety (observed major and minor bleeding events) of rivaroxaban for EHIT prophylaxis in EVLA with and without concomitant phlebectomy. METHODS: Demographic, procedural, and outcome data of all patients with EVLA of the great, accessory, or small saphenous vein and EHIT prophylaxis with 10 mg/d rivaroxaban between 2012 and 2014 were reviewed and analyzed in this investigator-initiated multicenter retrospective observational single-arm study...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28623412/long-term-follow-up-after-endoscopic-trans-sphenoidal-surgery-or-initial-observation-in-clivus-chordomas
#16
Jon Ramm-Pettersen, Radek Frič, Jon Berg-Johnsen
BACKGROUND: Resection of clivus chordomas through extensive skull base approaches is associated with high mortality and morbidity even in experienced hands. We report our experience with endoscopic trans-sphenoidal surgery, or a "wait-and-scan" strategy in selected patients. METHOD: Ten patients were diagnosed with clivus chordomas during an 8-year period. Six patients underwent primary treatment with endoscopic trans-sphenoidal surgery, followed by adjuvant proton-beam therapy in three of these patients...
June 16, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28622885/the-impact-of-prophylactic-external-carotid-artery-ligation-on-postoperative-bleeding-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma
#17
John Gleysteen, Scott Troob, Tyler Light, Daniel Brickman, Daniel Clayburgh, Peter Andersen, Neil Gross
BACKGROUND: Transoral robotic-assisted surgery (TORS) is increasingly utilized in the treatment of oropharyngeal squamous cell carcinoma (OPSCC). Postoperative bleeding is a significant and potentially fatal complication of TORS. Prophylactic ligation of ipsilateral external carotid artery (ECA) branches is a recognized strategy to reduce postoperative bleeding risk. We examined the incidence and sequelae of postoperative oropharyngeal bleeding with and without routine ECA ligation. METHODS: OPSCC patients treated with TORS between 2010 and 2015 with minimum 30days follow up were included...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28621591/rates-of-intraoperative-complications-and-conversion-to-laparotomy-during-laparoscopic-ovariectomy-performed-by-veterinary-students-161-cases-2010-2014
#18
Adam M Nylund, Adam Drury, Heather Weir, Eric Monnet
OBJECTIVE To assess rates of intraoperative complications and conversion to laparotomy associated with supervised veterinary students performing laparoscopic ovariectomy in dogs. DESIGN Retrospective case series. ANIMALS 161 female shelter dogs for which elective laparoscopic ovariectomy had been performed by supervised senior (fourth-year) veterinary students from 2010 through 2014. PROCEDURES Medical records of all dogs were reviewed and data collected regarding duration of surgery, surgical complications and other characteristics, and whether conversion to laparotomy was required...
July 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28621297/endoscopic-ultrasound-with-or-without-fine-needle-aspiration-has-a-meaningful-impact-on-clinical-care-in-the-pediatric-population
#19
Amit Raina, Maire A Conrad, Benjamin Sahn, Alireza Sedarat, Gregory G Ginsberg, Nuzhat A Ahmad, Vinay Chandrasekhara, Petar Mamula, Michael L Kochman
BACKGROUND AND OBJECTIVES: The safety and utility of endoscopic ultrasound (EUS) for the evaluation and management of gastrointestinal (GI) tract disorders among adults has been established. The literature on safety and efficacy in a pediatric referral population (under 21 years of age) is limited. We hypothesized that EUS is safe and useful in the pediatric population. We reviewed the pediatric EUS experience at a single tertiary-care system. We describe the indications, findings, safety, technical success rate, and impact on clinical outcomes...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28620895/the-standardized-postoperative-checklist-for-bariatric-surgery-a-tool-for-safe-early-discharge
#20
Stefanie R van Mil, Lucia E Duinhouwer, Guido H H Mannaerts, L Ulas Biter, Martin Dunkelgrun, Jan A Apers
BACKGROUND: Morbidly obese patients are at higher risk of complications after surgery. In bariatric surgery, pre- and intra-operative checklists are commonly used to identify high-risk patients preoperatively, to decrease the number of postoperative complications. This pilot study evaluates the effect of a postoperative checklist in bariatric surgery, addressing regularly measured parameters, on the occurrence and early recognition of complications. METHODS: An in-house developed postoperative checklist was used on the first postoperative day after bariatric surgery and included information on nausea, pain, temperature, heart rate, and laboratory markers...
June 15, 2017: Obesity Surgery
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