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https://www.readbyqxmd.com/read/29916342/a-pilot-study-to-assess-safety-and-feasibility-of-intrathecal-immunoglobulin-for-the-treatment-of-adults-with-tetanus
#1
Huynh Thi Loan, Lam Minh Yen, Evelyne Kestelyn, Nguyen Van Hao, Nguyen Thi Hoang Mai, Duong Bich Thuy, Ha Thi Hai Duong, Nguyen Thi Phuong Dung, Nguyen Hoan Phu, Pham Thi Lieu, Tran Tan Thanh, Ronald Geskus, H Rogier van Doorn, Le Van Tan, Duncan Wyncoll, Nicholas P J Day, Tran Tinh Hien, Guy E Thwaites, Nguyen Van Vinh Chau, C Louise Thwaites
Tetanus remains a significant burden in many low- and middle-income countries. The tetanus toxin acts within the central nervous system and intrathecal antitoxin administration may be beneficial, but there are safety concerns, especially in resource-limited settings. We performed a pilot study to assess the safety and feasibility of intrathecal human tetanus immunoglobulin in five adults with tetanus before the conduct of a large randomized controlled trial. Intrathecal injection via lumbar puncture was given to all patients within a median 140 (range 100-165) minutes of intensive care unit (ICU) admission...
June 18, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29915915/post-embolization-neurological-syndrome-after-embolization-for-intracranial-and-skull-base-tumors-transient-exacerbation-of-neurological-symptoms-with-inflammatory-responses
#2
Yujiro Tanaka, Takao Hashimoto, Daisuke Watanabe, Hirofumi Okada, Daichi Kato, Shigeru Aoyagi, Jiro Akimoto, Michihiro Kohno
PURPOSE: Pre-operative embolization is an effective treatment strategy for hypervascular intracranial and skull base tumors. However, neurological complications resulting from tumor swelling, cranial nerve ischemia, or hemorrhage can occur after embolization. The purpose of this study was to examine the relationship between neurological complications following pre-operative embolization and minor adverse events including fever, headache, or increasing inflammation, which are common after embolization for abdominal tumors (i...
June 18, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29914803/totally-laparoscopic-multi-stage-restorative-proctocolectomy-for-inflammatory-bowel-diseases-a-prospective-study-on-safety-efficacy-and-long-term-results
#3
Gianluca M Sampietro, Francesco Colombo, Alice Frontali, Caterina M Baldi, Stefania Carmagnola, Andrea Cassinotti, Alessandra Dell'Era, Alessandro Massari, Paola Molteni, Dario Dilillo, Paolo Fociani, Massimo Tonolini, Giovanni Maconi, Paolo Fiorina, Fabio Corsi, Roberto Bianco, Manuela Nebuloni, Gianvincenzo Zuccotti, Sandro Ardizzone, Diego Foschi
BACKGROUND: Laparoscopic ileo-pouch-anal anastomosis (IPAA) has been reported as having low morbidity and several advantages. AIMS: To evaluate safety, efficacy and long-term results of laparoscopic IPAA, performed in elective or emergency settings, in consecutive unselected IBD patients. METHODS: All the patients received totally laparoscopic 2-stage (proctocolectomy and IPAA - stoma closure) or 3-stage (colectomy - proctectomy and IPAA - stoma closure) procedure according to their presentation...
May 21, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29914256/early-postoperative-follow-up-after-craniosynostosis-surgery
#4
Ebru Atike Ongun, Oguz Dursun, Mehmet Saim Kazan, Banu Nur, Ercan Mıhçı
Background/aim: Declined morbidity rates after craniosynostosis surgery indicate bypassing the pediatric intensive care unit (PICU) course to minimize treatment costs and bed usage. The aim of this study is to examine the incident rates of PICU admission and assess its necessity. Materials and methods: A retrospective analysis of 41 patients (operated on by open surgical techniques) between July 2011 and December 2015 was carried out. Intraoperative/postoperative vital signs, hemodynamic and metabolic parameters, estimated blood loss (EBVloss), blood transfusions, length of PICU, and hospitalizations were recorded...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29913704/cathepsin-s-is-increased-in-cerebrospinal-fluid-from-patients-with-neuropathic-pain-a-support-of-the-microglia-hypothesis-in-humans
#5
Torsten Gordh, Anne-Li Lind, Constantin Bodolea, Ellen Hewitt, Anders Larsson
Aims Cathepsin S has been reported to be a biomarker of spinal microglial activation, a process suggested to be involved in the pathophysiology of chronic neuropathic pain. So far this has been shown only in animal experiments. The aim of this study was to investigate the concentrations of cathepsin S in human cerebrospinal fluid (CSF) samples from a well-defined patient cohort suffering from neuropathic pain as compared to controls. Methods CSF samples from patients suffering from chronic neuropathic pain (n = 14) were analyzed for cathepsin S levels using commercial sandwich ELISAs (DY1183, R&D Systems, Minneapolis, MN, USA)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912821/cochlear-patency-after-translabyrinthine-vestibular-schwannoma-surgery
#6
Fiona C E Hill, Alasdair Grenness, Shannon Withers, Claire Iseli, Robert Briggs
OBJECTIVES: To determine the temporal occurrence of fluid signal changes on T2-weighted magnetic resonance imaging (T2MRI) that occur in the cochlear lumen after translabyrinthine surgery. STUDY DESIGN: Retrospective case control study. SETTING: Tertiary referral neurotology center. SUBJECTS AND METHODS: Seventy-one patients were identified who underwent translabyrinthine removal of a vestibular schwannoma between 2010 and 2014; of these 49 were included as they had postoperative T2 MRI at 6, 18, and 48 months available postsurgery...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29911754/assessment-of-the-association-between-post-tonsillectomy-hemorrhage-and-weather-conditions
#7
Rom Mendel, Maayan Yitshak-Sade, Michael Nash, Ben-Zion Joshua
BACKGROUND: The most common complication after tonsillectomy is bleeding. We investigated whether performing the procedure during the summer or the winter affects the bleeding rate. OBJECTIVES: To investigate whether there is an association between meteorological conditions and the occurrence of post-tonsillectomy hemorrhage (PTH) in the southern Israel Negev region. METHODS: All patients who underwent tonsillectomy from 2001-2013 at the Soroka Medical Center were included...
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29911581/real-time-ultrasound-guided-infraorbital-nerve-block-to-treat-trigeminal-neuralgia-using-a-high-concentration-of-tetracaine-dissolved-in-bupivacaine
#8
Kenichi Takechi, Amane Konishi, Kotaro Kikuchi, Shiho Fujioka, Tomomi Fujii, Toshihiro Yorozuya, Koh Kuzume, Takumi Nagaro
Background Trigeminal neuralgia is a neuropathic disorder characterized by episodes of intense pain in the face. Drug therapy is the first choice of treatment. However, in cases where drug therapy are contraindicated due to side effects, patients can get pain relief from lengthy neurosurgical procedures. Alternatively, a peripheral trigeminal nerve block can be easily performed in an outpatient setting. Therefore it is a useful treatment option for the acute paroxysmal period of TN in patients who cannot use drug therapy...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911132/the-clinical-outcome-of-one-stage-high-tibial-osteotomy-and-anterior-cruciate-ligament-reconstruction-a-current-concept-systematic-and-comprehensive-review
#9
REVIEW
Michael-Alexander Malahias, Omid Shahpari, Maria-Kyriaki Kaseta
Background: Patients with an anterior cruciate ligament-deficient varus-angulated knee may need not only an isolated high tibial osteotomy (HTO), but also an additional anterior cruciate ligament reconstruction (ACLR). A number of prospective clinical trials have been published considering the combination of HTO and ACL reconstruction. Our aim was to investigate whether one-stage combined HTO and ACL reconstruction is an effective, well-established technique with long-term results in the treatment of varus-angulated knees with ACL deficiency...
May 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29910673/development-of-an-anti-adhesive-membrane-for-use-in-video-assisted-thoracic-surgery
#10
Akiko Uemura, Toshiharu Fukayama, Takashi Tanaka, Yasuko Hasegawa-Baba, Makoto Shibutani, Ryou Tanaka
Background : The need to prevent postoperative adhesions after surgery has been considered a significant challenge in thoracic surgery, especially with the advent of video-assisted thoracic surgery (VATS). While preventive materials for postoperative adhesions have been studied for many years, they are all still in the development phases. Methods : In this animal study, an insoluble hyaluronic acid membrane was used in VATS for wedge resection to test its operability and to examine the body's response to the membrane...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29909190/pediatric-robotic-assisted-laparoscopic-pyeloplasty-does-age-matter
#11
T Kawal, A K Srinivasan, D Shrivastava, J Van Batavia, D Weiss, C Long, A R Shukla
BACKGROUND: Although shown to be safe in infancy, robotic-assisted laparoscopic pyeloplasty (RALP) for ureteropelvic junction obstruction (UPJO) is most commonly performed in older children and adolescents. OBJECTIVE: This study examined a contemporary RALP experience at a single tertiary pediatric center and compared outcomes in infants aged ≤1 year with an older cohort. METHODS AND DESIGN: All RALP procedures were entered into an Institutional Review Board-approved data registry from 2012 to 2016...
June 1, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29908810/effects-of-overstocking-at-the-feedbunk-on-the-growth-performance-and-sorting-characteristics-of-a-forage-based-diet-offered-for-ad-libitum-intake-to-replacement-holstein-dairy-heifers
#12
W K Coblentz, M S Akins, N M Esser, R K Ogden, S L Gelsinger
Various forms of overcrowding are common in heifer-rearing operations. Our objectives for this study were to evaluate the effects of overstocking at the feedbunk (100, 133, 160, or 200% of capacity) on the growth performance, feedbunk sorting behaviors, and hygiene of 128 gravid Holstein heifers (475 ± 55.3 kg) consuming an alfalfa haylage and corn silage diet diluted with processed wheat straw at an inclusion rate of 25.2% (DM basis). In this study, heifers were overstocked only at the feedbunk, and not with respect to available freestalls or pen area...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908524/neoadjuvant-radiotherapy-changing-the-treatment-sequence-to-allow-immediate-free-autologous-breast-reconstruction
#13
Kimberley Hughes, Derek Neoh
BACKGROUND:  Locally advanced breast cancer (LABC) is traditionally treated with a multimodal approach of chemotherapy, surgery, and postmastectomy radiotherapy (PMRT). The advantages of immediate breast reconstruction (IBR) are well described and include improved aesthetic outcomes, fewer surgical procedures, shorter treatment period, and a higher quality of life. However, this sequence makes immediate free autologous reconstruction more challenging as PMRT can have deleterious and unpredictable effects on the flap...
June 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29907987/mutational-analysis-of-the-pro-peptide-of-a-marine-intracellular-subtilisin-protease-supports-its-role-in-inhibition
#14
Gro E K Bjerga, Øivind Larsen, Hasan Arsın, Adele Williamson, Antonio García-Moyano, Ingar Leiros, Pål Puntervoll
Intracellular subtilisin proteases (ISPs) have important roles in protein processing during the stationary phase in bacteria. Their unregulated protein degrading activity may have adverse effects inside a cell, but little is known about their regulatory mechanism. Until now, ISPs have mostly been described from Bacillus species, with structural data from a single homolog. Here, we study a marine ISP originating from a phylogenetically distinct genus, Planococcus sp. The enzyme was successfully overexpressed in E...
June 16, 2018: Proteins
https://www.readbyqxmd.com/read/29907601/pragmatic-and-evidence-based-approach-to-paediatric-cerebrospinal-fluid-reference-limits-for-white-cell-count-and-concentrations-of-total-protein-and-glucose
#15
Nicky Josman, Nancy W S Tee, Matthias Maiwald, Liat Hui Loo, Clement K M Ho
BACKGROUND: It is often impractical for each laboratory to establish its own paediatric reference intervals. This is particularly true for specimen types collected using invasive procedures, for example, cerebrospinal fluid (CSF). METHODS: Published CSF reference intervals for white cell count, and concentrations of total protein and glucose were reviewed by stakeholders in a paediatric hospital. Consensus reference intervals for the three CSF parameters were then subjected to verification using guidelines from the Clinical Laboratory Standards Institute and residual CSF specimens...
June 15, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29907212/predicting-the-response-to-a-bronchodilator-in-patients-with-airflow-obstruction-and-lung-cancer
#16
Kazuhiro Ueda, Junichi Murakami, Toshiki Tanaka, Kumiko Yoshida, Taiga Kobayashi, Kimikazu Hamano
BACKGROUND: The aim of the present study was to clarify the predictors of the response of patients with resectable lung cancer and untreated airflow obstruction to tiotropium, an antimuscarinic bronchodilator. METHODS: Tiotropium was administered to 29 preoperative patients with untreated airflow obstruction. The forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1 ) were measured before and after the introduction of tiotropium. The response to tiotropium was determined based on the percentage gain in the FEV1 ...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29905603/treacher-collins-syndrome-and-tracheostomy-decannulation-using-mandibular-distraction-osteogenesis
#17
Safi Ali-Khan, Christopher Runyan, Gil Nardini, Pradip Shetye, David Staffenberg, Joseph G McCarthy, Roberto L Flores
INTRODUCTION: Treacher Collins syndrome (TC) and Pierre Robin sequence (RS) are associated with hypoplastic mandible, glossoptosis, and consequent airway obstruction. Although TC and RS are often grouped together, airway outcomes of bilateral mandibular distraction osteogenesis (MDO) have not been specifically studied in TC. The purpose of this study is to report on the clinical outcomes of MDO in the TC patient population. MATERIALS AND METHODS: A twenty-year single-institution retrospective review of all patients with TC who underwent bilateral MDO was performed...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29904479/massive-fetal-cervical-teratoma-managed-with-the-ex-utero-intrapartum-treatment-exit-procedure
#18
Emily Olivares, Justin Castellow, Jamil Khan, Susanne Grasso, Victor Fong
Teratomas are rare congenital tumors typically comprising all 3 germ cell layers. Cervical teratomas arise in the neck and represent a minority of all teratomas. These are associated with high morbidity and mortality because of their propensity to cause airway obstruction. Demonstration on prenatal magnetic resonance imaging is uncommon, especially for a tumor of this size. Fetuses diagnosed with large neck masses are managed through cesarean section with the ex utero intrapartum treatment procedure to secure the airway, such as in our case of a large cervical teratoma in the female fetus of a 30-year-old mother who went into preterm labor...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29903852/transplants-for-non-lethal-conditions-a-case-against-hand-transplantation-in-minors
#19
Charles E Hedges, Philip M Rosoff
Human allografts for life-threatening organ failure have been demonstrated to be lifesaving and are now considered to be standard of care for many conditions. Transplantation of non-vital anatomic body parts has also been accomplished. Hand transplantation after limb loss in adults has been shown to offer some promising benefits in both functional and psychological measures in preliminary studies. It has been suggested to expand eligibility criteria to include minors, with one such operation having already been performed...
June 14, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29903007/nutraceutical-potentialities-of-tunisian-argan-oil-based-on-its-physicochemical-properties-and-fatty-acid-content-as-assessed-through-bayesian-network-analyses
#20
Mohsen Hanana, Hajer Mezghenni, Rayda Ben Ayed, Ali Ben Dhiab, Slim Jarradi, Bassem Jamoussi, Lamia Hamrouni
BACKGROUND: Argan oil is traditionally produced by cold pressing in South-western Morocco where rural population uses it as edible oil as well as for its therapeutic properties which give them in counterpart valuable income. Given the economical interest of this oil, several attempts of fraudulency have been registered in the world global market leading to loss of authenticity. Our purpose is to launch a program of Tunisian Argan oil valorization since trees from this species have been introduced sixty years ago in Tunisia...
June 15, 2018: Lipids in Health and Disease
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