keyword
https://read.qxmd.com/read/38507087/-outcome-of-abo-incompatible-living-donor-kidney-transplants-a%C3%A2-plea-for-crossover-living-donor-kidney-transplantation
#1
REVIEW
L Liefeldt, P Glander, F Friedersdorff
BACKGROUND: The lack of postmortem donated organs is the background to varyingly high rates of living-donor kidney transplants worldwide. ABO blood group-incompatible living-donor kidney transplants have also been established for at least 20 years. The equivalence of the results of ABO-incompatible and ABO-compatible transplants has recently been questioned. OBJECTIVE: In the sense of a critical reflection of our own kidney transplant program, we were interested in comparing ABO-incompatible with ABO-compatible living-donor kidney transplants...
March 20, 2024: Urologie
https://read.qxmd.com/read/38476806/novel-two-infusion-pump-technique-for-exchange-transfusion-in-a-hyperbilirubinemic-neonate
#2
Naramreddy Sudheesh Reddy, Aditi Rawat, Sagar Karotkar, Ashish Varma, Amar Taksande, Revat J Meshram, Chaitanya Kumar Javvaji, SreeHarsha Damam
Neonatal hyperbilirubinemia is a common concern in newborns, with ABO blood group incompatibility serving as a significant risk factor for severe jaundice. This case report outlines the successful management of a 2.5 kg female infant born to a primigravida mother with ABO incompatibility-induced hyperbilirubinemia. The neonate, born at 38.4 weeks via lower segment cesarean section, exhibited signs of jaundice at 91 hours of life, prompting screening and subsequent confirmation of serum bilirubin levels 26...
February 2024: Curēus
https://read.qxmd.com/read/38458763/neonatal-herpes-simplex-virus-encephalitis-with-intracranial-bleeding-in-a-newborn-baby-with-concurrent-rhesus-incompatibility
#3
JOURNAL ARTICLE
Pascal Clemence, Haika Mariki, Martha Mkony, Karim Premji Manji
We report a baby with neonatal herpes simplex virus (HSV) encephalitis concurrent with Rrhesus (Rh) incompatibility. He was delivered by a Ggravida 2 mother with a history of miscarriage in her previous pregnancy at a gestation age of 4 months. She had Bblood group 0 and Rrhesus negative. The baby was noticed to have jaundice on day one1 of life accompanied by generalised petechiae on the face and upper chest. A full blood picture revealed severe anaemia and severe thrombocytopaenia and HSV 1/2 IgM was positive...
March 8, 2024: BMJ Case Reports
https://read.qxmd.com/read/38453497/nondomestic-felid-abc-blood-phenotyping-genotyping-and-crossmatching
#4
JOURNAL ARTICLE
Lily Parkinson, Henrike Kuder, Alexandra Kehl, Amie Koenig, Jennifer Good, Jennifer Hausmann, Urs Giger
Based upon previous clinical experience with domestic cats ( Felis catus ), the ability to assess ABC blood types and blood (in-)compatibilities of nondomestic felids, and adequately consider and plan for blood transfusions, may be important. Although nondomestic felids appear to have an ABC blood group system similar to domestic cats, typing with point-of-care kits and by CMAH genotyping for domestic cats have not been reported. In this study, 162 blood samples from 18 different nondomestic felid species (cheetah [ Acinonyx jubatus , n = 42], lion [ Panthera leo , n = 33], tiger [ Panthera tigris , n = 23], Canada lynx [ Lynx canadensis , n = 11], snow leopard [ Uncia uncia , n = 10], puma [ Puma concolor , n = 7], clouded leopard [ Neofelis nebulosa , n = 6], serval [ Leptailurus serval , n = 5], jaguar [ Panthera onca , n = 5], fishing cat [ Prionailurus viverrinus , n = 4], Pallas cat [ Felis manul , n = 3], bobcat [ Lynx rufus , n = 3], ocelot [ Leopardus pardalis , n = 3], black footed cat [ Felis nigripes , n = 2], leopard [ Panthera pardus , n = 2], African wildcat [ Felis lybica , n = 1], caracal [ Caracal caracal , n = 1], and sand cat [ Felis margarita , n = 1]) were ABC blood typed by laboratory and point-of-care tests, genotyped for four known CMAH variants for type B and type C ( AB ) phenotypes, and crossmatched with one another and domestic type A cats...
March 2024: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://read.qxmd.com/read/38453222/passenger-lymphocyte-syndrome-following-minor-abo-mismatched-liver-transplantation
#5
JOURNAL ARTICLE
Akash Mathavan, Urszula Krekora, Andrew Chase Kleehammer, Akshay Mathavan
Passenger lymphocyte syndrome is an immunologic disorder observed in solid organ and haematopoietic stem cell transplantation in which B lymphocytes within a donor graft are transferred to the recipient and subsequently produce circulating antibodies against host red blood cell antigens. The syndrome is most likely to occur in minor ABO blood group mismatched or Rh incompatible transplantation. Although generally mild and self-limited, the resulting haemolytic burden has the potential to increase the risk of infection, graft failure and death...
March 7, 2024: BMJ Case Reports
https://read.qxmd.com/read/38425018/rhd-mismatch-does-not-affect-haematopoietic-recovery-graft-versus-host-disease-and-survival-in-allogeneic-haematopoietic-cell-transplantation-a-japanese-registry-based-study
#6
JOURNAL ARTICLE
Takaaki Konuma, Naoyuki Uchida, Wataru Takeda, Noriko Doki, Satoshi Yoshihara, Tetsuya Nishida, Takuro Kuriyama, Masatsugu Tanaka, Hiroyuki Ohigashi, Hirohisa Nakamae, Yuta Katayama, Shuichi Ota, Yoshiko Hashii, Fumihiko Ishimaru, Takahiro Fukuda, Marie Ohbiki, Yoshiko Atsuta
BACKGROUND AND OBJECTIVES: ABO blood group mismatch between the donor and the recipient can affect the success of the transplant as well as problems with the red blood cells during allogeneic haematopoietic cell transplantation (HCT). However, the impact of the Rhesus (Rh) D mismatch on transplant outcomes in allogeneic HCT has been poorly elucidated. MATERIALS AND METHODS: We retrospectively evaluated the impact of the RhD mismatch on post-transplant outcomes in 64,923 patients who underwent allogeneic HCT between 2000 and 2021 using a Japanese registry database...
February 29, 2024: Vox Sanguinis
https://read.qxmd.com/read/38402345/rituximab-added-to-conditioning-regimen-significantly-improves-erythroid-engraftment-in-major-incompatible-abo-group-hematopoietic-stem-cell-transplantation
#7
JOURNAL ARTICLE
Maria Chiara Finazzi, Alessandra Weber, Chiara Pavoni, Anna Grassi, Maria Caterina Micò, Alessandra Algarotti, Federico Lussana, Alessandro Rambaldi
ABO-group major incompatibility hematopoietic stem cell transplantation (HSCT) increases the risk of delayed red cell engraftment and other immunological complications. In this study, we evaluated the efficacy of pre-transplant infusion of rituximab in patients with ABO-incompatibility in improving red blood cell engraftment after HSCT, measured by time to reach transfusion independence. We performed a retrospective, single-center study including 131 consecutive patients transplanted with major or bidirectional ABO-incompatible grafts between 1st January 2013 and 31st December 2019...
February 24, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38402098/the-increasing-need-for-abo-blood-group-genotyping-and-quality-assurance-implications-for-laboratory-implementation
#8
REVIEW
Amena Usmani, Gerald P Morris, Cathi Murphey
ABO blood group antigens are critical determinants of immunologic self and non-self and are ubiquitously expressed on all cellular tissues. Antibodies against non-self ABO antigens are naturally present and can mediate pathologic reactions against incompatible transfused blood cells and transplanted tissues. Laboratory testing for ABO antigens and isoagglutinins is essential for safe and effective transfusion and transplantation. Testing for ABO antigens has traditionally depended on serologic testing. However, there is increasing need for evaluation of genetic analysis of ABO antigens, to enable evaluation of ABO blood group in cases where serologic testing may be ambiguous or impossible to accurately perform...
February 23, 2024: Human Immunology
https://read.qxmd.com/read/38398058/characterization-of-novel-rhd-allele-variants-and-their-implications-for-routine-blood-group-diagnostics
#9
JOURNAL ARTICLE
Eva M Matzhold, Maria Bemelmans, Helene Polin, Günther F Körmöczi, Marlies Schönbacher, Thomas Wagner
The Rh system, including the highly immunogenic D antigen, is one of the clinically most important blood group systems in transfusion medicine. Numerous alleles of the RHD gene are associated with variant RhD phenotypes. In case of Rh incompatibility, some of them can induce hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. Thus, accurate blood group diagnostics are critical for safe transfusion therapy. We characterized phenotypes of four individuals revealing weakened D expression during routine pre-transfusion testing...
February 18, 2024: Biomedicines
https://read.qxmd.com/read/38361942/pre-transplant-donor-specific-antibodies-in-abo-incompatible-kidney-transplantation-data-from-the-swiss-transplant-cohort-study
#10
JOURNAL ARTICLE
Yun Deng, Lukas Frischnknecht, Caroline Wehmeier, Olivier de Rougemont, Jean Villard, Sylvie Ferrari-Lacraz, Déla Golshayan, Monique Gannagé, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson
BACKGROUND: Living donor (LD) kidney transplantation in the setting of ABO blood group incompatibility (ABOi) has been previously reported to be associated with increased risk for antibody-mediated rejection (ABMR). It is however unclear if the presence of pre-transplant donor specific antibodies (DSA) works as an additive risk factor in the setting of ABOi and if DSA positive ABOi transplants have a significantly worse long-term outcome as compared with ABO compatible (ABOc) DSA positive transplants...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38355207/rare-cause-of-jaundice-in-a-term-newborn
#11
JOURNAL ARTICLE
Inês Silva Costa, Beatriz Vala, Sofia Costa, Raquel Henriques
Neonatal jaundice is a frequently observed occurrence in full-term newborns and typically manifests between 48 and 96 hours following birth. Early-onset jaundice is primarily induced by pathological factors, namely sepsis, hemolysis and an excessive accumulation of bilirubin resulting from the breakdown of red blood cells.We present a case involving a full-term newborn with an uneventful perinatal history, who exhibited jaundice within the initial day of life and was subsequently admitted to the neonatal intensive care unit to commence intensive phototherapy...
February 14, 2024: BMJ Case Reports
https://read.qxmd.com/read/38351735/successful-treatment-pure-red-cell-aplasia-after-abo-major-mismatched-allogeneic-hematopoietic-stem-cell-transplantation-with-avatrombopag-and-low-dose-rituximab
#12
JOURNAL ARTICLE
Junjie Cao, Shaoyan Lu, Danjie Luo, Renzhi Pei, Ying Lu, Dong Chen, Xiaohong Du, Shuangyue Li
BACKGROUND: Pure red cell aplasia (PRCA) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with ABO major incompatibility is characterized by transfusion dependent anemia. No standard treatment existed for PRCA following allo-HSCT yet. STUDY DESIGN AND METHODS: We conducted a retrospective study, and reported our experience with the use of avatrombopag and lower dose rituximab to treat five patients with PRCA subsequent to major ABO-incompatible allo-HSCT...
February 13, 2024: Transfusion
https://read.qxmd.com/read/38334336/blood-type-abo-and-the-cytokine-profile-of-follicular-fluid-in-women-undergoing-ivf-et
#13
JOURNAL ARTICLE
Rafal Adamczak, Natalia Ewa Ukleja-Sokołowska, Kinga Lis, Valentyna Chopyak, Anna Havrylyuk, Dagmara Adamczak, Wojciech Cnota, Zbigniew Bartuzi, Mariusz Dubiel
OBJECTIVES: ABO blood type was hypothesised to be related to a number of infertility processes. There is still an open debate on ABO blood group's incompatibility and infertility. It was associated with ovarian reserve in women with subfertility. There is still not enough information on the influence of blood type and the immunology of follicular fluid (FF). MATERIAL AND METHODS: 78 patients were selected, who underwent in vitro fertilization (IVF) between April 2021 and January 2022...
February 9, 2024: Ginekologia Polska
https://read.qxmd.com/read/38286423/a-description-of-ivig-use-in-term-neonates-with-ab0-incompatibility
#14
JOURNAL ARTICLE
Michael Daunov, Andrea Schlosser, Sindhoosha Malay, Jaclyn Adams, Rachael Clark, Lauren Ferrerosa, Irina Pateva
Objective To determine if treatment with IVIG of neonates with ABO incompatibility (without Rh incompatibility) results in decreased number of packed red blood cell (pRBC) transfusions and phototherapy use. Study Design An IRB-approved, single-institution retrospective study was conducted. Neonates ≥38 weeks gestational age born between 01/01/2007 and 12/31/2016 with ABO incompatibility were included. The comparison among groups was performed using Chi square and Fisher exact test for categorical variables; continuous variables were assessed by Kruskal-Wallis test...
January 29, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38285369/cell-free-dna-and-next-generation-sequencing-for-prenatal-diagnosis
#15
JOURNAL ARTICLE
Klaus Rieneck
Deep sequencing by NGS of targeted amplicons can identify rare genetic variants in a pool of DNA where the vast majority of genomic DNA does not contain the variant. This approach can be used to detect a previously described paternally inherited, fetal variant in cell-free DNA (cfDNA) in maternal plasma. This is useful in cases where risk for the fetus is contingent upon inheritance of a paternal variant that the woman does not have. Both pathogenic and non-pathogenic variants that the woman does not have can be detected...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38274919/intentional-lung-transplantation-due-to-abo-incompatibility-a-case-report
#16
Fabio Varón-Vega, Adriana Rincón, Leidy Prada, Eduardo Tuta-Quintero, Luis J Téllez
We present a case of a 16-year-old adolescent female with blood group O+ who was diagnosed with cystic fibrosis (CF). The patient had to be hospitalized due to septic shock and respiratory failure, and extracorporeal membrane oxygenation and mechanical ventilation were applied. Faced with high urgency, she was promptly enlisted for a lung transplant, ultimately receiving a blood group A1 deceased donor lung through rescue allocation. Bilateral incompatible lung transplantation, with parental consent, was successfully performed...
December 2023: Curēus
https://read.qxmd.com/read/38245405/treatment-with-plasma-exchange-of-a-pregnant-woman-with-anti-pp1pk-alloimmunization-a-case-report
#17
JOURNAL ARTICLE
O Pignalosa, E Vigorita, M Capuano, S Caruso, A Mastroianni, S De Martino, G Vaccaro, D Meomartini, C Nocera
The histo-blood group antigens P, P1 and Pk are a closely related set of glycosphingolipid structures expressed by red blood cells and other tissues. None of these three characters is expressed on p cells, a null phenotype that arises in the context of homozygous mutation of the A4GALT gene. Subjects with p phenotype spontaneously develop a natural alloantibody named anti-PP1Pk, which is a mixture of IgG and IgM against P1, P and Pk. While anti-P1 is a weak cold antibody with poor clinical significance, anti-P and anti-Pk antibodies are potent haemolysins responsible for severe hemolytic transfusion reactions...
January 10, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38237929/comparative-analysis-of-ab-vs-abo-specific-plasma-for-desensitization-in-blood-group-o-recipients-an-in-vitro-study
#18
JOURNAL ARTICLE
Young Ae Lim
Neutralizing capacity measurement (NCM) of soluble ABH substances (SAS) in plasma was assessed to guide the selection of the appropriate ABO group of fresh-frozen plasma (FFP) for plasma exchange (PE) in blood group O recipients with ABO-incompatible transplantations. Neutralizing capacity was assessed by measuring anti-A and/or anti-B titers in samples comprising one unit of O FFP and 10 O EDTA plasma samples and subtracting the binary logarithm of the titer in each group with a saline dilution. Ten EDTA plasma samples with Lewis b (Leb ) antigen positivity and 10 sets of pooled FFP from each blood group were used as diluents...
January 19, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38189423/-rare-red-blood-group-discovered-by-a-blood-group-discrepancy-a-case-report
#19
JOURNAL ARTICLE
Wafa Aissa, Sonia Chouaieb, Nawell Bellil, Houda Kaabi, Slama Hmida
ABO typing is essential for preventing ABO incompatibility transfusion reactions. Discrepancy exists when reactions in forward grouping do not match with reverse grouping. Any discrepancies reported should be investigated so that correct blood group is reported minimizing the chances of transfusion reaction. The most common causes of ABO discrepancy are cold autoantibodies and missing serum reactivity. We report a rare alloantibody anti-PP1Pk discovered during the resolution of a grouping difficulty with a positive control...
January 1, 2024: Annales de Biologie Clinique
https://read.qxmd.com/read/38153256/accidental-abo-incompatible-pediatric-liver-transplantation-with-blood-group-antigen-immune-and-operational-tolerance-a-case-report-with-21-years-of-follow-up
#20
Hyo-Sin Kim, Soo Jin Na Choi, Ho Kyun Lee, Sola Lee
Liver transplantation is a critical procedure for patients with end-stage liver disease, but it is often hindered by ABO-incompatibility between the donor and recipient, which can lead to immediate humoral rejection. We present a unique case involving a 10-month-old patient who, by accident, received an ABO-incompatible partial liver transplant from a type A mother without undergoing desensitization. Remarkably, during a 21-year follow-up period, the patient exhibited no signs of humoral or graft rejection, despite nonadherence to medication...
December 31, 2023: Korean journal of transplantation
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