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Blood group incompatibility

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https://www.readbyqxmd.com/read/27904614/the-predictive-value-of-blood-neutrophil-lymphocyte-ratio-in-patients-with-end-stage-liver-cirrhosis-following-abo-incompatible-liver-transplantation
#1
Bingyi Lin, Lei Geng, Zhiyun Zheng, Junjun Jia, Tian Shen, Jing Zhang, Lin Zhou, Shusen Zheng
BACKGROUND: The study was designed to assess the role of preoperative neutrophil, lymphocyte, and neutrophil-lymphocyte ratio (NLR) in predicting survival outcomes of ABO-incompatible liver transplantation (LT). MATERIALS AND METHODS: We retrospectively collected the demographic and clinical characteristics of 71 patients with end-stage liver cirrhosis following ABO-incompatible LT in this study. Kaplan-Meier survival analysis and Cox multiple factors regression analysis were performed to determine the independent risk factors from preoperative blood parameters for poor prognosis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27894887/ultrasound-tissue-pulsatility-imaging-suggests-impairment-in-global-brain-pulsatility-and-small-vessels-in-elderly-patients-with-orthostatic-hypotension
#2
Julie Biogeau, Thomas Desmidt, Paul-Armand Dujardin, Redouane Ternifi, Charlotte Eudo, Emilie Vierron, Jean-Pierre Remenieras, Frédéric Patat, Vincent Camus, Thierry Constans
BACKGROUND: Orthostatic hypotension (OH) is highly prevalent in the elderly, and this population can be exposed to serious complications, including falls and cognitive disorders, as well as overall mortality. However, the pathophysiology of OH is still poorly understood, and innovative methods of cerebral blood flow (CBF) assessment have been required to accurately investigate cerebrovascular reactivity in OH. OBJECTIVES: We want to compare brain tissue pulsatility (BTP) changes during an orthostatic challenge in elderly patients over 80 with and without OH...
November 25, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27860206/effect-of-abo-incompatibility-on-t-cell-flow-cytometry-crossmatch-results-prior-to-living-donor-kidney-transplantation
#3
M Lindemann, V Lenz, B Nyadu, F M Heinemann, A Heinold, H Guberina, U Eisenberger, N Lachmann, C Schönemann, A Kribben, A Paul, P A Horn, O Witzke
BACKGROUND: Due to its high sensitivity, the flow cytometry crossmatch (FCXM) has been described as valuable tool for identifying an optimal donor. We here focused on the impact of ABO incompatibility on FCXM results. METHODS: We analyzed 29 ABO incompatible and 89 ABO compatible donor-recipient pairs (73 and 175 data sets, respectively) prior to living donor kidney transplantation. In all patients, lymphocytotoxic crossmatches for B and T cells were negative. RESULTS: Recipients with blood group O (A to O and B to O) displayed significantly (P < 0...
November 18, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27857529/severe-hemolytic-disease-of-the-premature-newborn-due-to-rh1-incompatibility-a-case-report
#4
Jean Uwingabiye, Hafid Zahid, Fayçal Labrini, Abdelhak El Khazraji, Anass Yahyaoui, Rachid Hadef, Nezha Messaoudi
We report a case of dramatic outcome of severe hemolytic disease in a newborn due to RH1 incompatibility. A newborn with A RH1 blood group was admitted in the Mohammed V Military Teaching Hospital for the problem of hydrops fetalis associated with RH1 incompatibility. The blood group of his mother, aged 31, was AB RH1-negative and that of his 37 year old father was A RH1. The mother had a history of 4 term deliveries, 3 abortions, and 1 living child. There was no prevention by anti-D immunoglobulin postpartum...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27848264/underlying-mechanism-and-specific-prevention-of-hemolysis-induced-platelet-activation
#5
Thomas Gremmel, Simone Fedrizzi, Günter Weigel, Beate Eichelberger, Simon Panzer
Thromboembolic complications significantly impair the outcome of hemolytic disorders. We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be prevented by inhibition of the ADP P2Y12 receptor. In the current study, we therefore sought to investigate the mechanism and inhibition of hemolysis-induced platelet activation. The expression of activated integrin αIIbß3 was determined by flow cytometry, and platelet aggregation was assessed by multiple electrode platelet aggregometry...
November 16, 2016: Platelets
https://www.readbyqxmd.com/read/27842454/the-role-of-ugt1a1-promoter-polymorphism-and-exon-1-mutations-in-neonatal-jaundice
#6
Hülya Halis, Hacer Ergin, Aylin Köseler, Erol Ömer Atalay
OBJECTIVE: In the present study we investigated the effects of promoter polymorphism and an exon-1 mutation (G71R) in the UGT1A1 gene in neonates with unexplained hyperbilirubinemia and direct coombs-negative [DC(-)] ABO incompatibility. METHODS: Two hundred term neonates in their first week of life and without additional icterogenic factors were included in the study. Neonates with a serum total bilirubin (STB) level≥17 mg/dL constituted the hyperbilirubinemia group (n = 100) while the control group comprised healthy neonates with a STB level < 12...
November 14, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27812254/evaluation-of-magnetized-erythrocyte-group-antigens-to-detect-abo-antibodies
#7
O Nathalang, K Intharanut, P Sriwanitchrak, M Setthakarn, S Duan, H Wang, S Ding, Y Li
Screening for IgM titers of anti-A and anti-B is recommended when providing ABO incompatible platelet transfusion. The life-time of reagent cells depends upon the preservative diluents. We aimed to evaluate the IgM titers of anti-A and anti-B testing with magnetized-erythrocyte group antigens (MEGA) and fresh RBCs and study the relationship of ABO antibody titers between both techniques. Altogether, 100 serum samples from group O donors at the National Blood Centre, Thai Red Cross Society, Bangkok, Thailand were included...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27796108/a-study-on-the-prevalence-of-dog-erythrocyte-antigen-1-1-and-detection-of-canine-babesia-by-polymerase-chain-reaction-from-apparently-healthy-dogs-in-a-selected-rural-community-in-zimbabwe
#8
Solomon Dhliwayo, Tariro A Makonese, Belinda Whittall, Silvester M Chikerema, Davies M Pfukenyi, Musavenga T Tivapasi
A study was carried out to determine the prevalence of blood group antigen dog erythrocyte antigen (DEA) 1.1 in mixed breed dogs in rural Chinamhora, Zimbabwe. DEA 1.1 is clinically the most important canine blood group as it is the most antigenic blood type; hence, DEA 1.1 antibodies are capable of causing acute haemolytic, potentially life-threatening transfusion reactions. In this study, blood samples were collected from 100 dogs in Chinamhora, and blood typing was carried out using standardised DEA 1.1 typing strips with monoclonal anti-DEA 1...
October 26, 2016: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/27788792/outcome-of-abo-incompatible-living-donor-renal-transplantations-a-single-center-experience-from-eastern-india
#9
D S Ray, S Thukral
BACKGROUND: With the incessantly increasing number of patients on the waiting list for renal transplants, crossing the blood group barrier can substantially increase the donor pool. We started ABO-incompatible (ABOi) renal transplantation in 2013 with a relatively low-cost preconditioning protocol (additional cost, ∼$1200). This study reports the short-term outcome of ABOi renal transplantations performed at our institution. METHODS: A total of 45 adult ABOi kidney transplant recipients (KTRs) were included in the study...
October 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27768816/growth-phase-dependent-control-of-r27-conjugation-is-mediated-by-the-interplay-between-the-plasmid-encoded-regulatory-circuit-trhr-trhy-htda-and-the-camp-regulon
#10
Marta Gibert, Sonia Paytubi, Sergi Beltrán, Antonio Juárez, Carlos Balsalobre, Cristina Madrid
Plasmids of the incompatibility group HI1 (IncHI1) have been isolated from several Gram-negative pathogens and are associated with the spread of multidrug resistance. Their conjugation is tightly regulated and it is inhibited at temperatures higher than 30°C, indicating that conjugation occurs outside warm-blooded hosts. Using R27, the prototype of IncHI1 plasmids, we report that plasmid transfer efficiency in E. coli strongly depends on the physiological state of the donor cells. Conjugation frequency is high when cells are actively growing, dropping sharply when cells enter the stationary phase of growth...
October 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27736265/changes-in-t-cells-after-abo-incompatible-liver-transplantation
#11
Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh, Gyu-Seong Choi, Jae Berm Park, Eun-Suk Kang, Sung Joo Kim, Suk-Koo Lee
PURPOSE: T lymphocytes are an essential component of allograft rejection and tolerance. The aims of the present study are to analyze the characteristics of T-cell subsets between ABO-incompatible living donor liver transplantation (ABO-I LDLT) and ABO-compatible LDLT (ABO-C LDLT). MATERIALS AND METHODS: Between April 2013 and June 2014, 61 patients underwent adult LDLT. ABO-I LDLT patients received rituximab and all patients received basiliximab as induction therapy and tacrolimus as maintenance therapy...
October 13, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27732768/assessing-cannabis-consumption-frequency-is-the-combined-use-of-free-and-glucuronidated-thccooh-blood-levels-of-diagnostic-utility
#12
Marianne Hädener, Marie Martin Fabritius, Stefan König, Christian Giroud, Wolfgang Weinmann
Heavy cannabis consumption is considered incompatible with safe driving. In Swiss traffic policy, drivers suspected of regular cannabis use are therefore required to undergo medical assessment of their long-term fitness to drive. A whole blood concentration of the cannabis metabolite 11-nor-9-carboxy-Δ(9) -tetrahydrocannabinol (THCCOOH) of 40 µg/L is currently used by Swiss forensic experts as decision limit for regular cannabis consumption. The present study aimed to investigate the suitability of THCCOOH-glucuronide blood levels as an additional and/or better marker for the frequency of cannabis use...
October 12, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27730689/measurement-of-haemolysis-markers-following-transfusion-of-uncrossmatched-low-titer-group-o-whole-blood-in-civilian-trauma-patients-initial-experience-at-a-level-1-trauma-centre
#13
J N Seheult, D J Triulzi, L H Alarcon, J L Sperry, A Murdock, M H Yazer
BACKGROUND/OBJECTIVES: The safety of administering uncrossmatched, group O, cold-stored, whole blood (cWB) during civilian trauma resuscitation was evaluated. METHODS/MATERIALS: Male trauma patients with haemorrhage-induced hypotension who received leuko-reduced uncrossmatched group O+, low titer (<50) anti-A and -B, platelet-replete cWB during initial resuscitation were included. The biochemical markers of haemolysis (lactate dehydrogenase, total bilirubin, haptoglobin, creatinine, serum potassium) were measured on the day of cWB receipt (day 0), and over the next 2 days, reports of transfusion reactions and total blood product administration in first 24 h of admission were recorded...
October 12, 2016: Transfusion Medicine
https://www.readbyqxmd.com/read/27683633/current-techniques-for-ab0-incompatible-living-donor-liver-transplantation
#14
REVIEW
Silke Rummler, Astrid Bauschke, Erik Bärthel, Heike Jütte, Katrin Maier, Patrice Ziehm, Christina Malessa, Utz Settmacher
For a long time, it was considered medical malpractice to neglect the blood group system during transplantation. Because there are far more patients waiting for organs than organs available, a variety of attempts have been made to transplant AB0-incompatible (AB0i) grafts. Improvements in AB0i graft survival rates have been achieved with immunosuppression regimens and plasma treatment procedures. Nevertheless, some grafts are rejected early after AB0i living donor liver transplantation (LDLT) due to antibody mediated rejection or later biliary complications that affect the quality of life...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27663090/abo-incompatible-renal-transplantation-following-lung-transplantation
#15
G I Snell, A K Davis, S Menahem, S Kotecha, H M Whitford, B J Levvey, M Paraskeva, A Webb, G W Westall, R G Walker
We present management strategies utilised for the first case of an urgent live-donor ABO incompatible B blood group renal transplant, in a patient with a prior A blood group lung transplant for cystic fibrosis. Three years on, renal function is excellent and stable, whilst lung function has improved.
November 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27630853/effectiveness-of-pooled-platelet-transfusion-in-concordant-and-discordant-groups-among-dengue-patients
#16
Amoolya Bhat, Vijaya Chowdappa, Smita Surendra Masamatti
INTRODUCTION: Dengue affects more than 50 million people per year and is one of the most common causes of severe thrombocytopaenia. Thrombocytopaenia is a common complication of dengue and other viral fevers apart from malaria, typhoid, leptospirosis, leukaemia and megaloblastic anaemia. A platelet count of <20,000/μl is characteristically seen in dengue haemorrhagic fever and dengue fever. It results from immune complex mediated platelet destruction or bone marrow suppression. Severe thrombocytopaenia <10,000/μl is one of the indications for prophylactic platelet transfusion therapy to prevent haemorrhage...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27618621/abo-blood-group-antigen-mismatch-has-an-impact-on-outcome-after-allogeneic-peripheral-blood-stem-cell-transplantation
#17
Matthias Grube, Daniel Wolff, Norbert Ahrens, Philipp Y Herzberg, Wolfgang Herr, Ernst Holler
ABO blood group antigen incompatibility (ABO mismatch) is not an obstacle to allogeneic stem cell transplantation (allo-SCT). However, the impact on clinical outcome after allo-SCT remains controversial. We analyzed 512 patients after allogeneic peripheral blood SCT (allo-PBSCT) for an association of ABO mismatch with transfusion requirements, myeloid and platelet engraftment, the incidence of GvHD, relapse, transplant-related mortality (TRM), and overall survival (OS). A total of 260 patients underwent ABO-mismatched transplantation and the control group consisted of 252 patients with ABO-matched allo-PBSCT...
September 12, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27611703/blood-group-a-mothers-are-more-likely-to-develop-anemia-during-antenatal-intravenous-immunoglobulin-treatment-of-fetal-and-neonatal-alloimmune-thrombocytopenia
#18
Madhavi Lakkaraja, Jenny C Jin, Karen C Manotas, Cheryl A Vinograd, Polina Ferd, Julia Gabor, Megan Wissert, Richard L Berkowitz, Janice G McFarland, James B Bussel
BACKGROUND: Incompatibility between parental platelet (PLT) antigens may lead to sensitization of mother and development of fetal and neonatal alloimmune thrombocytopenia (FNAIT) resulting in fetal thrombocytopenia. Intravenous immunoglobulin (IVIG) with or without prednisone is the most effective, evidence-based antenatal treatment for subsequent FNAIT-affected pregnancies. IVIG infusion causes hemolysis in other settings, the degree depending upon patient blood groups (BGs). STUDY DESIGN AND METHODS: In ClinicalTrials...
October 2016: Transfusion
https://www.readbyqxmd.com/read/27605855/anti-ih-an-antibody-worth-mention
#19
Nithya Mohanan, Nittin Henry, Aboobacker Mohamed Rafi, Susheela J Innah
A 72-year-old female with co-morbidities posted for surgical correction of fracture neck of femur without any history of transfusions was noted to have a hemoglobin level of 7 g/dl and packed red blood cells transfusion was ordered. Pretransfusion tests demonstrated A1B group with D positive on forward grouping. Reverse grouping showed a varying grade of agglutination with A, B, and O cells. Agglutination being stronger at 4°C. Antibody screening showed pan-agglutination, direct Coomb's test and auto control were negative...
July 2016: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/27587287/the-impact-of-psychosocial-stress-on-conceptual-knowledge-retrieval
#20
Christian J Merz, Florian Dietsch, Michael Schneider
The acquisition of conceptual knowledge in scientific domains is among the central aims of school instruction because this semantic declarative knowledge helps individuals make interferences and explain complex phenomena. Recent research shows that naïve concepts acquired during childhood persist in long-term memory long after learning the scientifically correct concepts in school. In this study, we investigated the effects of stress on the retrieval of these conceptual representations. To this end, 40 healthy men were randomly assigned to either psychosocial stress or a control condition and evaluated, as quickly and accurately as possible, statements that were compatible with scientific concepts or incompatible with those concepts...
October 2016: Neurobiology of Learning and Memory
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