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Atypical antipsychotic* AND Child AND adverse effects

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https://www.readbyqxmd.com/read/26908483/sleep-difficulties-and-medications-in-children-with-autism-spectrum-disorders-a-registry-study
#1
Beth A Malow, Terry Katz, Ann M Reynolds, Amy Shui, Margaret Carno, Heidi V Connolly, Daniel Coury, Amanda E Bennett
OBJECTIVES: Sleep difficulties are common in children with autism spectrum disorders, with wide-ranging effects on the child's daytime behavior. We reviewed data within our Autism Speaks Autism Treatment Network Registry to determine the prevalence of sleep difficulties and patterns of medication use. METHODS: Data from 1518 children ages 4 to 10 years were analyzed to determine the number of children documented to have sleep difficulties by parent-completed questionnaires and clinician-completed forms and how these findings related to the use of sleep medications...
February 2016: Pediatrics
https://www.readbyqxmd.com/read/24944356/risperidone-in-children-and-adolescents-with-conduct-disorder-a-single-center-open-label-study
#2
Eyüp Sabri Ercan, Ayşe Kutlu, Sibel Cıkoğlu, Baybars Veznedaroğlu, Serpil Erermiş, Azmi Varan
BACKGROUND: Risperidone is one of the most commonly used atypical antipsychotic drugs in the treatment of children and adolescents. However, the data about its use in children and adolescents with conduct disorder (CD) are limited. OBJECTIVE: The aim of this study was to investigate the effectiveness and tolerability of risperidone in controlling major symptoms of CD in children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and severe CD...
January 2003: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/24816004/metabolic-effects-of-antipsychotics-in-prepubertal-children-a-retrospective-chart-review
#3
COMPARATIVE STUDY
Tanya Ebert, Yael Midbari, Ronen Shmilovitz, Ira Kosov, Moshe Kotler, Abraham Weizman, Anca Ram
OBJECTIVE: Antipsychotics, especially atypical ones, are in common use in children and adolescents with psychotic or affective spectrum disorders, as well as in various other psychopathologies. The adverse effects of atypical antipsychotics in children and adolescents are similar to those seen in adults, and include weight gain, elevated blood glucose levels, and hyperlipidemia. In this retrospective chart review, we compared these adverse events in children who were treated with typical, atypical, or no antipsychotic treatment...
May 2014: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/24614763/psychopharmacological-interventions-in-autism-spectrum-disorder
#4
REVIEW
Laura C Politte, Charles A Henry, Christopher J McDougle
After participating in this educational activity, the physician should be better able to1. Prescribe the appropriate psychotropic medication to treat symptoms of ASD.2. Identify the side effects of the psychotropic medications used to treat ASD.Autism spectrum disorders (ASDs) are characterized by core deficits in social communication and language, and restrictive and repetitive behaviors that cause significant functional impairment and distress for affected individuals and their caregivers. The increasing prevalence of ASD, most recently estimated as 1 in 88 children, presents an ever-increasing burden on families, schools, medical systems, and society at large...
March 2014: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/24580061/toxicity-and-clinical-outcomes-of-paliperidone-exposures-reported-to-u-s-poison-centers
#5
M E Tsay, W Klein-Schwartz, B Anderson
CONTEXT: Paliperidone is an atypical antipsychotic that was approved in the U.S. in 2006, and is also available in Canada, Australia, New Zealand, Europe, and Asia. Information regarding paliperidone overdoses is limited to case reports. Serious toxicity has yet to be reported. OBJECTIVE: To evaluate the toxicity of paliperidone exposures using a national poison center database. METHODS: A retrospective, observational case series of single-substance paliperidone cases reported to the National Poison Data System from 2007 to 2012 was conducted...
March 2014: Clinical Toxicology
https://www.readbyqxmd.com/read/24346956/aripiprazole-alone-or-in-combination-for-acute-mania
#6
REVIEW
Rachel Brown, Matthew J Taylor, John Geddes
BACKGROUND: Bipolar disorder is a mental disorder characterised by episodes of elevated or irritable mood (manic or hypomanic episodes) and episodes of low mood and loss of energy (depressive episodes). Drug treatment is the first-line treatment for acute mania with the initial aim of rapid control of agitation, aggression and dangerous behaviour. Aripiprazole, an atypical antipsychotic, is used in the treatment of mania both as monotherapy and combined with other medicines. The British Association of Psychopharmacology guidelines report that, in monotherapy placebo-controlled trials, the atypical antipsychotics, including aripiprazole, have been shown to be effective for acute manic or mixed episodes...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23972700/practice-parameter-for-the-assessment-and-treatment-of-children-and-adolescents-with-schizophrenia
#7
REVIEW
Jon McClellan, Saundra Stock
This Practice Parameter reviews the literature on the assessment and treatment of children and adolescents with schizophrenia. Early-onset schizophrenia is diagnosed using the same criteria as in adults and appears to be continuous with the adult form of the disorder. Clinical standards suggest that effective treatment includes antipsychotic medications combined with psychoeducational, psychotherapeutic, and educational interventions. Since this Practice Parameter was last published in 2001, several controlled trials of atypical antipsychotic agents for early-onset schizophrenia have been conducted...
September 2013: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/23782129/the-diagnosis-and-management-of-delirium-in-infancy
#8
COMPARATIVE STUDY
Susan Beckwitt Turkel, Julienne R Jacobson, C Jane Tavaré
OBJECTIVE: Atypical antipsychotics have been documented to be effective in the management of delirium in adults and older children, but despite considerable need, their use has been less studied in the very young. A retrospective chart review was undertaken to describe the use of atypical antipsychotics in controlling symptoms of delirium in infants and toddlers. METHODS: All psychiatric inpatient consultations performed during a 3 year period were reviewed to identify children <36 months old diagnosed with delirium...
June 2013: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/23588704/safety-and-pharmacokinetics-of-atypical-antipsychotics-in-children-and-adolescents
#9
REVIEW
Silvio Caccia
Pediatric behavioral and affective disorders often require antipsychotic therapy, in combination with psychotherapeutic interventions, for their treatment and stabilization. Although pharmacotherapy can include either typical or atypical antipsychotics, the latter are generally preferred because of their apparently lower risk of adverse effects. Recent controlled trials have demonstrated the efficacy of some of these agents (including aripiprazole, clozapine, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone) in adolescent schizophrenia and children or adolescent bipolar mania, or to treat severe aggression and self-injury in the context of autism in children and adolescents...
June 2013: Paediatric Drugs
https://www.readbyqxmd.com/read/23519708/weight-gain-and-other-metabolic-adverse-effects-associated-with-atypical-antipsychotic-treatment-of-children-and-adolescents-a-systematic-review-and-meta-analysis
#10
REVIEW
Noor B Almandil, Ying Liu, Macey L Murray, Frank M C Besag, Katherine J Aitchison, Ian C K Wong
OBJECTIVES: The aims of this study were to provide a systematic review and meta-analysis of the effects of atypical antipsychotics in children and adolescents on weight gain (primary objective) and other metabolic parameters (secondary objective). METHODS: A systematic literature review and meta-analysis of double-blind, randomized, controlled trials were conducted. The data sources used were as follows: EMBASE, PubMed, BIOSIS, International Pharmaceutical Abstracts, The Cochrane database (Clinical Trials), Clinical Trials Government Registry, The metaRegister of Controlled Trials, WHO (World Health Organization) Clinical Trials Registry Platform, and PsycINFO(®)...
April 2013: Paediatric Drugs
https://www.readbyqxmd.com/read/23334073/aripiprazole-induced-seizure-in-a-3-year-old-child-a-case-report-and-literature-review
#11
REVIEW
Farouq I Thabet, Rochelle T Sweis, Suja A Joseph
Aripiprazole is an atypical antipsychotic medication that is a partial dopamine D(2) and serotonin 5-hydroxytryptamine (1A) receptor agonist and 5-hydroxytryptamine (2A) receptor antagonist. It has a safer profile compared to other antipsychotic medications with regard to its effect on weight, glucose tolerance, prolactin level, and cardiac conduction. The common neurological adverse effects include headache, agitation, insomnia, sleepiness, and extrapyramidal symptoms. Seizures have not been reported in the pediatric population and only twice in adult patients...
January 2013: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/23002695/-pharmacotherapy-for-conduct-disorder-in-children-and-adolescents
#12
REVIEW
Tomer Levy, Yuval Bloch
RATIONALE: Conduct disorder (CD) is a common disorder which is typified by a variety of behavioral problems and aggression. Treating CD is a challenge in the field of child and adolescent psychiatry. The use of drugs for this indication is broad despite the lack of systematic knowledge on this subject. OBJECTIVES: This paper aims to review research data available on the efficacy of the different medication classes and agents for CD and to specify the considerations that should be taken accordingly...
July 2012: Harefuah
https://www.readbyqxmd.com/read/22972123/atypical-antipsychotics-for-disruptive-behaviour-disorders-in-children-and-youths
#13
REVIEW
Jik H Loy, Sally N Merry, Sarah E Hetrick, Karolina Stasiak
BACKGROUND: Disruptive behaviour disorders include conduct disorder, oppositional defiant disorder and disruptive behaviour not otherwise specified. Attention deficit hyperactivity disorder (ADHD) is frequently associated with disruptive behaviour disorders. The difficulties associated with disruptive behaviour disorders are demonstrated through aggression and severe behavioural problems. These often result in presentation to psychiatric services and may be treated with medications such as atypical antipsychotics...
2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22772923/systemic-review-of-aripiprazole-for-the-treatment-of-children-and-adolescents-with-tic-disorders
#14
REVIEW
Ahmad Ghanizadeh
This study aimed to systematically review the data related to the treatment of tic disorders through aripiprazole administration, an atypical antipsychotic. The databases of MEDLINE/PubMed and Google Scholar were searched using the key words: "aripiprazole," "tic," and "Tourette," and the relevant titles retrieved. Thirty-five articles met the inclusion criteria and were further scrutinized. Most of the articles were case reports, and only 2 published trials included control groups. The number of randomized double-blind controlled clinical trials was zero, therefore, no strong evidence, provided by one, or more well-designed randomized controlled clinical trials, was found...
July 2012: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/22722499/aripiprazole-for-the-treatment-of-tourette-syndrome-a-case-series-of-100-patients
#15
Claudia Wenzel, Alexandra Kleimann, Stefanie Bokemeyer, Kirsten R Müller-Vahl
OBJECTIVE: Aripiprazole is an atypical neuroleptic with agonistic and antagonistic dopaminergic and serotonergic effects. Because preliminary data obtained from uncontrolled studies suggest that aripiprazole may be effective in the treatment of tics, we performed a retrospective study with a large group of patients with Tourette syndrome. METHODS: One hundred patients (78 men and 22 women; mean ± SD age, 27.1 years (± 11.5) years) who had been treated with daily doses of 5 to 45 mg (mean, 17...
August 2012: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/22592735/aripiprazole-for-autism-spectrum-disorders-asd
#16
REVIEW
Heidi Ching, Tamara Pringsheim
BACKGROUND: Autism spectrum disorders (ASD) include Autistic Disorder, Asperger's Disorder and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). Irritability related to ASD has been treated with antipsychotics. Aripiprazole, a third generation atypical antipsychotic, is a relatively new drug that has a unique mechanism of action different from other antipsychotics. OBJECTIVES: To determine the safety and efficacy of aripiprazole for individuals with ASD...
2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22364403/atypical-antipsychotic-medications-to-control-symptoms-of-delirium-in-children-and-adolescents
#17
COMPARATIVE STUDY
Susan Beckwitt Turkel, Julienne Jacobson, Elizabeth Munzig, C Jane Tavaré
BACKGROUND: Atypical antipsychotics have been documented to be effective in the management of delirium in adults, but despite considerable need, their use has been less studied in pediatric patients. OBJECTIVE: A retrospective chart review was done to describe the use of atypical antipsychotics in controlling symptoms of delirium in children and adolescents. METHODS: Pharmacy records at Children's Hospital Los Angeles were reviewed to identify patients to whom antipsychotic agents were dispensed over a 24-month period...
April 2012: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/22111125/-the-metabolic-syndrome-and-antipsychotics-in-children-and-adolescents
#18
REVIEW
Netta Dori, Tamar Green
Significant weight gain is a well known side-effect of atypical (second generation) antipsychotics. In recent years there is a growing body of evidence that atypical antipsychotics may cause metabolic syndrome which includes: increased waist circumference, lipid and glucose metabolism changes, and in some cases - elevation of blood pressure. During the last decade there has been a substantial increase in the use of atypical antipsychotics among children and adolescents, mainly due to lower rates of extrapyramidal side-effects, but also due to increased diagnosis of schizophrenia and bipolar disorder in youth, and the widespread use of atypical antipsychotics in disruptive behavior disorders...
October 2011: Harefuah
https://www.readbyqxmd.com/read/22014832/steroid-induced-psychosis-in-a-child-treatment-with-risperidone
#19
Ozlem Bag, Ilker Erdoğan, Zuhal Sivis Onder, Serdar Altinoz, Aysel Ozturk
Steroid-induced psychosis is one of the most serious adverse effects of steroid therapy but is a little-known complication in children. There is no clear mechanism model for steroid-induced behavioral disturbance, but it may be related with dose or level of free fraction of steroids. Our case is a 12-year-old boy diagnosed with steroid-induced psychosis and treated with risperidone, an atypical antipsychotic, due to distinct psychotic symptoms. Pediatricians should be aware of this rare complication when administering corticosteroids for various medical illnesses...
January 2012: General Hospital Psychiatry
https://www.readbyqxmd.com/read/21856116/efficacy-of-atypical-antipsychotic-medication-in-the-management-of-behaviour-problems-in-children-with-intellectual-disabilities-and-borderline-intelligence-a-systematic-review
#20
REVIEW
Gemma L Unwin, Shoumitro Deb
The use of medications to manage problem behaviours is widespread. However, robust evidence to support their use seems to be lacking. The aim was to review research evidence into the efficacy of atypical antipsychotic medication in managing problem behaviour in children with intellectual disabilities and borderline intelligence. A systematic review was conducted for placebo-controlled randomised double-blind trials. The included studies (N = 6) showed that risperidone was significantly more effective than placebo in managing problem behaviours...
November 2011: Research in Developmental Disabilities
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