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parkinson desease

Béla Faludi, József Janszky, Sámuel Komoly, Norbert Kovács
INTRODUCTION: Parkinson's disease is a well known representent of the movement disorder group of neurological disorders. The diagnosis of Parkinson's disease is based on specific symptoms and signs of movement abnormalities. In addition to classic motor symptoms, Parkinson's disease has characteristic non-motor features, and some of these emerges the classic signs. AIM: The authors discuss characteristics and therapeutic interventions in Parkinson's disease related sleep disturbances...
July 5, 2015: Orvosi Hetilap
N Callizot, J L Guénet, C Baillet, J M Warter, P Poindron
The frissonnant (fri) mutation is an autosomic recessive mutation which spontaneously appeared in the stock of C3H mice. fri mutant mice have locomotor instability and rapid tremor. Since tremor ceases when mutant mice have sleep or are anaesthetized, and because of their obvious stereotyped motor behavior, these mice could represent an inherited Parkinsonian syndrome. We show here that the fri/fri mouse fulfills two out of the three criteria required to validate an experimental model of human disease, that is isomorphism, homology and predictivity...
June 2001: Neurobiology of Disease
K Ito, P K Morrish, J S Rakshi, T Uema, J Ashburner, D L Bailey, K J Friston, D J Brooks
OBJECTIVE: To apply statistical parametric mapping to 18F-dopa PET data sets, to examine the regional distribution of changes in dopaminergic metabolism in early asymmetric Parkinson's disease. METHODS: Thirteen normal volunteers (age 57.7 (SD 16.5) years; four women, nine men ) and six patients (age 50.3 (SD 13.5) years; three women, three men) with asymmetric (right sided) Parkinson's disease were studied. Images from each dynamic dopa PET dataset were aligned and parametric images of 18F-dopa influx (Ki) were created for each subject...
June 1999: Journal of Neurology, Neurosurgery, and Psychiatry
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