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Case report diabetic nephropathy

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https://www.readbyqxmd.com/read/27872861/danish-nationwide-data-reveal-a-link-between-diabetes-mellitus-diabetic-retinopathy-and-glaucoma
#1
Anna Horwitz, Beáta Éva Petrovski, Christian Torp-Pedersen, Miriam Kolko
Aims. To determine the association between treatment against diabetes mellitus (DM) and treatment with antiglaucomatous drugs in the entire Danish population and to investigate the comorbidity between DM and its complications with antiglaucomatous treatment. Methods. Retrospective nationwide cohort study with data over a 16-year follow-up period. The National Danish Registry of Medicinal Products Statistics was used to identify all claimed prescriptions for antiglaucomatous medication and DM drugs. ICD-10 classifications were furthermore used to identify comorbidities between antiglaucomatous medication and the DM complications, diabetic retinopathy (DR), and nephropathy...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27833523/role-of-cytogenetic-biomarkers-in-management-of-chronic-kidney-disease-patients-a-review
#2
REVIEW
Zeba Khan, Manoj Pandey, Ravindra M Samartha
Chronic kidney disease (CKD) is much more common than people recognize, and habitually goes undetected and undiagnosed until the disease is well advanced or when their kidney functions is down to 25% of normal function. Genetic and non-genetic factors contribute to cause CKD. Non-genetic factors include hypertension, High level of DNA damage due to the production of reactive oxygen species and nucleic acid oxidation has been reported in CKD patients. Main genetic factor which causes CKD is diabetic nephropathy...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27777805/two-cases-of-human-t-lymphotropic-virus-type-i-associated-myelopathy-tropical-spastic-paraparesis-caused-by-living-donor-renal-transplantation
#3
Yasutaka Tajima, Mariko Matsumura, Hiroaki Yaguchi, Yasunori Mito
In rare instances, recipients of organ transplants from human T-lymphotropic virus type I- (HTLV-I-) positive donors reportedly developed neurologic symptoms due to HTLV-I-associated myelopathy (HAM). We present herein two cases of HAM associated with renal transplantation from HTLV-I seropositive living-donors. The first patient was a 42-year-old woman with chronic renal failure for twelve years and seronegative for HTLV-I. She underwent renal transplantation with her HTLV-I seropositive mother as the donor, and she developed HAM three years after the transplantation...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27747728/colchicine-induced-acute-neuromyopathy-in-a-patient-using-concomitant-fluconazole-case-report-and-literature-review
#4
Yi-Chia Su, Chih-Chien Wu
A 54-year-old woman presented at the emergency department after experiencing lower limb weakness and bilateral ankle pain for 2 days. She had a history of type 2 diabetes mellitus, diabetes mellitus nephropathy with chronic kidney disease, and chronic gouty arthritis. She had received 0.6 mg colchicine orally once or twice daily for 8 months. Four days prior to her emergency department visit, she was discharged from our nephrology ward, where she had been admitted because of a urinary tract infection. During hospitalization, she was treated with intravenous cefazolin for 7 days...
December 2015: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27721548/prescribing-patterns-of-medicines-in-chronic-kidney-disease-patients-on-maintenance-hemodialysis
#5
Sourav Chakraborty, Saugata Ghosh, Avishek Banerjea, Radha Raman De, Avijit Hazra, Swapan Kumar Mandal
OBJECTIVES: To study medicine prescribing pattern for chronic kidney disease (CKD) patients on maintenance hemodialysis. MATERIALS AND METHODS: This prospective observational study was conducted in hemodialysis unit of a teaching hospital with adult CKD patients on maintenance hemodialysis. Patients' clinical profile, drug-use pattern, and medication-related problem data were captured in a structured case report form and the data were analyzed descriptively. Adherence level was assessed by Morisky Medication-Taking Adherence Scale 4-item...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27688084/-diabetic-nephropathy-in-a-non-diabetic-patient
#6
Olga Balafa, Georgios Liapis, Paraskevi Pavlakou, Georgios Baltatzis, Rigas Kalaitzidis, Moses Elisaf
Kimmelstiel and Wilson originally described nodular glomerulosclerosis as the pathognomonic lesion of diabetic nephropathy. Nevertheless, nodular glomerulosclerosis pattern can rarely occur in non-diabetic patients. In such cases, the differential diagnosis includes membranoproliferative glomerulonephritis, light or heavy chain deposition disease, amyloidosis, fibrillary and immunotactoid glomerulonephritis and chronic hypoxic or ischemic conditions. In cases that the above entities cannot be proven, the term idiopathic nodular glomerulosclerosis is given...
December 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27633502/the-angiotensin-i-converting-enzyme-gene-i-d-variation-contributes-to-end-stage-renal-disease-risk-in-chinese-patients-with-type-2-diabetes-receiving-hemodialysis
#7
Ming Lu, Jianzhong Zhang, Ming Li, Xiaoxu Ge, Xu Dai, Jiao Zhao, Mingzhou Fu, Tao Wang, Xiyao Fang, Can Li, Rong Zhang, Weijing Zhao, Taishan Zheng, Feng Wang, Ming Yu, Tao Lei, Niansong Wang, Yuqian Bao, Limei Liu, Yanjun Liu, Weiping Jia
Whether the DD genotype of the angiotensin-I converting enzyme (ACE) I/D variation contributes to end-stage renal disease (ESRD) risk in type 2 diabetes mellitus (T2DM) remains controversial. Differences in study design, case and control definition, sample size and ethnicity may contribute to the discrepancies reported in association studies. We performed a case-control study to evaluate the association of the ACE I/D variation with ESRD risk in Chinese patients with T2DM receiving hemodialysis and analyzed the genotype-phenotype interaction...
November 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27509590/peritoneal-dialysis-treatment-of-metformin-associated-lactic-acidosis-in-a-diabetic-nephropathy-patient%C3%A2
#8
Jianjun Gao, Zhaoyan Gu, Yongxing Xu, Yu Na
We report a case of metformin-associated lactic acidosis (MALA) in a 66-year-old man with end-stage renal disease on peritoneal dialysis (PD). The patient presented with severe lactic acidosis and was treated successfully with automated peritoneal dialysis (APD). During the treatment, PD solution was prepared from hemofiltration substitute fluid. The prescription was 8 cycles of 2,000 mL over 24 hours with the prepared solution, and venoclysis with sodium bicarbonate to improve the acidosis. After 3 days of treatment, his lactic acidosis was corrected...
November 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27489763/nodular-glomerulosclerosis-in-a-patient-with-cystic-fibrosis-but-not-diabetes-mellitus-a-paediatric-case
#9
A D Lalayiannis, C Thompson, R Malcomson, D V Milford
BACKGROUND: Nodular glomerulosclerosis is seen in insulin dependent diabetic patients with nephropathy. Kimmelstiel-Wilson nodules on biopsy are considered pathognomonic. Diabetic nephropathy is a spectrum of glomerular and tubular disease which correlates with the duration of the diabetes and the extent of glycaemic control. CASE REPORT: An eleven year old girl with cystic fibrosis was referred with persistent heavy proteinuria. She underwent a renal biopsy which revealed nodular glomerulosclerosis with Kimmelstiel-Wilson-like nodules...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27472705/acute-thrombosis-of-a-transplanted-renal-artery-after-gastric-ulcer-bleeding-in-a-patient-with-a-long-term-well-functioning-renal-allograft-a-case-report-and-literature-review
#10
Chung-Kuan Wu, Jyh-Gang Leu, Cheng-Chun Wei, Shih-Chung Hsieh
BACKGROUND: Acute thrombosis of a transplanted renal artery is a serious vascular complication following renal allograft transplantation, which usually occurs within the first month after transplantation and often results in graft loss. It rarely occurs beyond the first month, except in a rejected kidney or in a kidney with high-grade transplant renal artery stenosis. RESULT: A 65-year-old male with a history of type 2 diabetes mellitus, hypertension, pulmonary tuberculosis, and end-stage renal disease was previously treated with hemodialysis (HD)...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27469157/hiv-associated-renal-disease-an-overview
#11
Nicola Wearne, Ikechi G Okpechi
The cause of the human immunodeficiency virus (HIV) epidemic in South Africa (SA) was worsened by the denial by key political players that HIV causes acquired immunodeficiency syndrome (AIDS). South Africa continues to have the highest rate of HIV world-wide, which has had a huge impact on the development of both chronic kidney disease and acute kidney injury. Fortunately, there is now an effective antiretroviral therapy (ART) roll-out program. SA is also dealing with a collision of epidemics of HIV, tuberculosis, and non-communicable disease, particularly hypertension and diabetes...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27449153/assessment-of-the-prevalence-and-risk-factors-of-ophthalmoplegia-among-diabetic-patients-in-a-large-national-diabetes-registry-cohort
#12
Eman S Al Kahtani, Rajiv Khandekar, Khalid Al-Rubeaan, Amira M Youssef, Heba M Ibrahim, Ahmed H Al-Sharqawi
BACKGROUND: There are limited data on the epidemiology and risk factors of ophthalmoplegia among diabetic patients. This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among diabetic patients. METHODS: This is an observational registry-based study using the Saudi National Diabetes Registry (SNDR) database to select diabetic patients regardless of their diabetes type. A total of 64,351 Saudi diabetic patients aged more than 18 years and registered in SNDR between January 2000 and December 2010 were analyzed to identify ophthalmoplegic cases...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27436034/rare-allergic-reaction-of-the-kidney-sitagliptin-induced-acute-tubulointerstitial-nephritis
#13
Ali A Alsaad, Sarah M Dhannoon, Sally-Ann L Pantin, Ivan E Porter
A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27432098/fluctuation-in-serum-sodium-levels-related-to-ipragliflozin-administration-in-a-patient-with-diabetic-nephropathy-and-sequela-of-traumatic-brain-injury
#14
Hideo Okonogi, Mikio Harada, Hironobu Sato, Kazuhiko Tokoro, Issei Nakayama, Nobuo Tsuboi, Yoichi Miyazaki, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo
A 46-year-old diabetic man underwent the removal of a hematoma caused by traumatic brain injury. After surgery, severe hyponatremia occurred. The subsequent administration of NaCl and fludrocortisone improved his laboratory findings. The patient was transferred to our hospital, and his insulin therapy was replaced by teneligliptin. One week later, ipragliflozin treatment was initiated and induced an immediate increase in the serum sodium levels. NaCl and fludrocortisone were therefore discontinued. However, hyponatremia recurred after ipragliflozin withdrawal due to a urinary tract infection...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27389722/efficacy-of-extracorporeal-albumin-dialysis-for-acute-kidney-injury-due-to-cholestatic-jaundice-nephrotoxicity
#15
Florence Sens, Justine Bacchetta, Maud Rabeyrin, Laurent Juillard
We report a case of a 37-year-old man with Maturity Onset Diabetes of the Youth (MODY) type 5, admitted for an episode of cholestasis and a simultaneous acute kidney injury (AKI). Chronic liver disease was due to a mutation in the transcription factor 2 (TCF2) gene, thus highlighting the need for a close liver follow-up in these patients. AKI was attributed to a cholemic nephropathy based on the following rationale: (1) alternative diagnoses were actively ruled out; (2) the onset of AKI coincided with the onset of severe hyperbilirubinaemia; (3) renal pathology showed large bile tubular casts and a marked tubular necrosis and (4) creatinine serum dramatically decreased when bilirubin levels improved after the first sessions of extracorporeal albumin dialysis (ECAD), thus suggesting its role in renal recovery...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27209436/incidence-mortality-and-prevalence-of-end-stage-chronic-renal-disease-in-the-bajo-lempa-region-of-el-salvador-a-ten-year-community-registry
#16
Ramón García-Trabanino, Carolina Hernández, Adrián Rosa, Jesús Domínguez Alonso
: The Bajo Lempa is an impoverished rural coastal region of El Salvador affected by the chronic kidney disease (CKD) epidemic known as Mesoamerican nephropathy. The local community organisation Fondo Social de Emergencia para la Salud (FSES) (Emergency social fund for health) is helping to fight the epidemic in 42 communities of the region (19,223 inhabitants; average age 26.7 years; 48.5% male; 40.2% <18 years). OBJECTIVES: To report annual rates of end-stage renal disease (ESRD) incidence and patient mortality in these communities during a 10-year period (2004-2013), and the prevalence of patients receiving renal replacement therapy (RRT) as of 31 December 2013...
May 18, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27165826/an-autopsy-study-suggests-that-diabetic-nephropathy-is-underdiagnosed
#17
Celine Q F Klessens, Tess D Woutman, Kimberley A M Veraar, Malu Zandbergen, Elisabeth J J Valk, Joris I Rotmans, Ron Wolterbeek, Jan A Bruijn, Ingeborg M Bajema
The reported prevalence of diabetic nephropathy (DN) among patients with diabetes varies widely. Most studies use the presence of microalbuminuria for clinical onset of DN in the absence of a histopathologic evaluation. In this autopsy study, we collected and analyzed data from a cohort of patients with type 1 or 2 diabetes and determined the prevalence of histologically proven DN in patients with or without clinical manifestations of renal disease. We also examined the distribution among histopathologic classes with respect to clinical parameters...
July 2016: Kidney International
https://www.readbyqxmd.com/read/27069968/iga-dominant-post-infectious-glomerulonephritis-making-another-case-in-support-of-renal-biopsy-in-type-2-diabetic-nephropathy
#18
Ali Nayer, Gargi Davda, Rima Pai, Luis M Ortega
BACKGROUND: Approximately one-third of individuals with type 2 diabetes mellitus will eventually develop diabetic nephropathy (DN). Impaired renal function in type 2 diabetics may also be secondary to non-diabetic renal disease (NDRD). NDRD in type 2 diabetics may occur alone in the absence of DN or may be superimposed on DN. Renal biopsy maybe indicated to establish the correct diagnosis and to ascertain the severity of glomerular and tubulointerstitial pathology. CASE: We report a patient with type 2 diabetes mellitus and chronic renal insufficiency who developed worsening of renal function in the setting of staphylococcal infection and antibiotic use...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27051142/idiopathic-nodular-glomerulosclerosis-report-of-two-cases-and-review-of-literature
#19
S Chandragiri, S Raju, K K Mukku, S Babu, M S Uppin
Nodular glomerulosclerosis, a pathological finding characterized by areas of marked mesangial expansion with accentuated glomerular nodularity can be seen in a number of conditions including diabetic nephropathy, amyloidosis, light chain deposition disease, fibrillary and immunotactoid glomerulopathy, collagen type III disease, nodular membranoproliferative glomerulonephritis, and Takayasu's arteritis. Idiopathic nodular glomerulosclerosis is a diagnosis of exclusion and is reported in patients with hypertension, smoking, chronic obstructive pulmonary disease, obesity, metabolic syndrome, etc...
March 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27051140/collapsing-glomerulopathy-in-a-case-of-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#20
N Singh, M Rathi, R Nada, A Sharma, A Goyal, R Ramachandran, V Kumar, H S Kohli, K L Gupta
Collapsing glomerulopathy (CG) is a pathological entity characterized by collapse and wrinkling of glomerular tuft, podocyte dedifferentiation and hyperplasia. CG may be idiopathic or secondary to other diseases. CG has been described with IgA nephropathy, membranous glomerulopathy, diabetic nephropathy, and lupus nephritis. However, till date there is no report of CG in association with the anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Here, we present a case of CG that developed during follow-up in a case of AAV with biopsy proven pauci-immune glomerulonephritis...
March 2016: Indian Journal of Nephrology
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