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https://www.readbyqxmd.com/read/29053070/relationship-between-patient-safety-indicator-events-and-comprehensive-stroke-center-volume-status-in-the-treatment-of-unruptured-cerebral-aneurysms
#1
Chad W Washington, L Ian Taylor, Robert J Dambrino, Paul R Clark, Gregory J Zipfel
OBJECTIVE The Agency of Healthcare Research and Quality (AHRQ) has defined Patient Safety Indicators (PSIs) for assessments in quality of inpatient care. The hypothesis of this study is that, in the treatment of unruptured cerebral aneurysms (UCAs), PSI events are less likely to occur in hospitals meeting the volume thresholds defined by The Joint Commission for Comprehensive Stroke Center (CSC) certification. METHODS Using the 2002-2011 National (Nationwide) Inpatient Sample, patients treated electively for a nonruptured cerebral aneurysm were selected...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29051905/evaluation-of-the-trends-concomitant-procedures-and-complications-with-open-and-arthroscopic-rotator-cuff-repairs-in-the-medicare-population
#2
Andrew R Jensen, Peter S Cha, Sai K Devana, Chad Ishmael, Theo Di Pauli von Treuheim, Anthony D'Oro, Jeffrey C Wang, David R McAllister, Frank A Petrigliano
BACKGROUND: Medicare insures the largest population of patients at risk for rotator cuff tears in the United States. PURPOSE: To evaluate the trends in incidence, concomitant procedures, and complications with open and arthroscopic rotator cuff repairs in Medicare patients. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: All Medicare patients who had undergone open or arthroscopic rotator cuff repair from 2005 through 2011 were identified with a claims database...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29049492/association-of-hsd3b1-genotype-with-response-to-androgen-deprivation-therapy-for-biochemical-recurrence-after-radiotherapy-for-localized-prostate-cancer
#3
Jason W D Hearn, Wanling Xie, Mari Nakabayashi, Nima Almassi, Chad A Reichard, Mark Pomerantz, Philip W Kantoff, Nima Sharifi
Importance: The variant HSD3B1 (1245C) allele enhances dihydrotestosterone synthesis and predicts resistance to androgen-deprivation therapy (ADT) for biochemically recurrent prostate cancer after prostatectomy and for metastatic disease. Whether this is true after radiotherapy is unknown. Objective: To determine whether the HSD3B1 (1245C) allele predicts worse clinical outcomes from ADT for biochemical recurrence after radiotherapy. Design, Setting, and Participants: The Prostate Clinical Research Information System at Dana-Farber Cancer Institute was used to identify the study cohort, which included men treated with ADT for biochemical recurrence after primary radiotherapy between 1996 and 2013...
October 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29049452/hsd3b1-and-response-to-a-nonsteroidal-cyp17a1-inhibitor-in-castration-resistant-prostate-cancer
#4
Nima Almassi, Chad Reichard, Jianbo Li, Carly Russell, Jaselle Perry, Charles J Ryan, Terence Friedlander, Nima Sharifi
Importance: The HSD3B1 (1245C) germline variant encodes for a gain-of-function missense in 3β-hydroxysteroid dehydrogenase isoenzyme 1 (3βHSD1) that results in increased dihydrotestosterone synthesis from extragonadal precursors and is predictive of more rapid progression to castration-resistant prostate cancer (CRPC). Objective: To determine whether the HSD3B1 (1245C) genotype is predictive of clinical response to extragonadal androgen ablation with nonsteroidal 17α-hydroxylase/17,20-lyase (CYP17A1) inhibition in men with metastatic CRPC...
October 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29048474/transinnominate-approach-for-transcatheter-aortic-valve-replacement-single-centre-experience-of-minimally-invasive-alternative-access
#5
Luigi Pirelli, Jacob S Scheinerman, Derek R Brinster, Nirav C Patel, Alaeldin Eltom, Jonathan M Hemli, Chad A Kliger
OBJECTIVES: Iliofemoral arteries have been the preferred access for transcatheter aortic valve replacement (TAVR). When these arteries are too small, calcified or tortuous, an alternative access must be considered. Transinnominate (TI) access is an extrathoracic approach that does not require manipulation of major neurovascular structures or the apex. The aim of this study is to evaluate the efficacy and safety of TI TAVR as an alternative access in patients with severe aortic stenosis not amenable to a transfemoral approach...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29047304/real-world-comparison-of-all-cause-hospitalizations-hospitalizations-due-to-stroke-and-major-bleeding-and-costs-for-nonvalvular-atrial-fibrillation-patients-prescribed-oral-anticoagulants-in-a-us-health-plan
#6
Alpesh Amin, Allison Keshishian, Lien Vo, Qisu Zhang, Oluwaseyi Dina, Chad Patel, Kevin Odell, Jeffrey Trocio
AIMS: Compare the risk of all-cause hospitalization and hospitalizations due to stroke/systemic embolism (SE) and major bleeding as well as associated health care costs for nonvalvular atrial fibrillation (NVAF) patients initiating apixaban, dabigatran, rivaroxaban, or warfarin. MATERIALS AND METHODS: NVAF patients initiating apixaban, dabigatran, rivaroxaban, or warfarin were selected from the OptumInsight Research Database from 01JAN2013-30SEP2015. Propensity score matching (PSM) was performed between apixaban and each oral anticoagulant...
October 19, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/29037509/structure-determination-of-disease-associated-peak-aaa-from-l-tryptophan-implicated-in-the-eosinophilia-myalgia-syndrome
#7
Klaus Klarskov, Hugo Gagnon, Pierre-Luc Boudreault, Chad Normandin, Baptiste Plancq, Eric Marsault, Gerald J Gleich, Stephen Naylor
The eosinophilia-myalgia syndrome (EMS) outbreak of 1989 that occurred in the USA and elsewhere was caused by the ingestion of L-tryptophan (L-Trp) solely manufactured by the Japanese company Showa Denko K.K. (SD). Six compounds present in the SD L-Trp were reported to be case-associated contaminants. However, "one" of these compounds, Peak AAA has remained structurally uncharacterized, despite the fact that it was described as "the only statistically significant (p=0.0014) contaminant". Here, we employ on-line microcapillary-high performance liquid chromatography-electrospray ionization mass spectrometry (LC-MS), and tandem mass spectrometry (MS/MS) to determine that Peak AAA is in fact two structurally related isomers...
October 13, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29037481/surgical-outcomes-among-elderly-women-with-endometrial-cancer-treated-by-laparoscopic-hysterectomy-a-nrg-gynecologic-oncology-group-study
#8
Erin A Bishop, James J Java, Kathleen N Moore, Nick M Spirtos, Michael L Pearl, Oliver Zivanovic, David M Kushner, Floor Backes, Chad A Hamilton, Melissa A Geller, Jean Hurteau, Cara Mathews, Robert M Wenham, Pedro T Ramirez, Susan Zweizig, Joan L Walker
OBJECTIVE: Tolerance of and complications due to minimally invasive hysterectomy and staging in the older endometrial cancer population is largely unknown despite the fact that this is the most rapidly growing age group in the United States. The objective of this retrospective review is to compare operative morbidity by age in patients on the Gynecologic Oncology Group (GOG) LAP2 trial. METHODS: This is a retrospective analysis of patients from GOG LAP2, a trial that included clinically early stage uterine cancer patients randomized to laparotomy vs...
October 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29037332/dihydrosterculic-acid-from-cottonseed-oil-suppresses-desaturase-activity-and-improves-liver-metabolomic-profiles-of-high-fat-fed-mice
#9
Chad M Paton, Roger A Vaughan, Ebru S Selen Alpergin, Fariba Assadi-Porter, Michael K Dowd
Polyunsaturated fatty acid (PUFA)-rich diets are thought to provide beneficial effects toward metabolic health in part through their bioactive properties. We hypothesized that increasing PUFA intake in mice would increase peroxisome proliferator activated receptor delta (PPARδ) expression and activity, and we sought to examine the effect of different PUFA-enriched oils on muscle PPARδ expression. One of the oils we tested was cottonseed oil (CSO) which is primarily linoleic acid (53%) and palmitic acid (24%)...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29031848/local-national-and-regional-viral-haemorrhagic-fever-pandemic-potential-in-africa-a-multistage-analysis
#10
David M Pigott, Aniruddha Deshpande, Ian Letourneau, Chloe Morozoff, Robert C Reiner, Moritz U G Kraemer, Shannon E Brent, Isaac I Bogoch, Kamran Khan, Molly H Biehl, Roy Burstein, Lucas Earl, Nancy Fullman, Jane P Messina, Adrian Q N Mylne, Catherine L Moyes, Freya M Shearer, Samir Bhatt, Oliver J Brady, Peter W Gething, Daniel J Weiss, Andrew J Tatem, Luke Caley, Tom De Groeve, Luca Vernaccini, Nick Golding, Peter Horby, Jens H Kuhn, Sandra J Laney, Edmond Ng, Peter Piot, Osman Sankoh, Christopher J L Murray, Simon I Hay
BACKGROUND: Predicting when and where pathogens will emerge is difficult, yet, as shown by the recent Ebola and Zika epidemics, effective and timely responses are key. It is therefore crucial to transition from reactive to proactive responses for these pathogens. To better identify priorities for outbreak mitigation and prevention, we developed a cohesive framework combining disparate methods and data sources, and assessed subnational pandemic potential for four viral haemorrhagic fevers in Africa, Crimean-Congo haemorrhagic fever, Ebola virus disease, Lassa fever, and Marburg virus disease...
October 11, 2017: Lancet
https://www.readbyqxmd.com/read/29029384/p53-upregulates-plc%C3%AE%C2%B5-ip3-ca-2-pathway-and-inhibits-autophagy-through-its-target-gene-rap2b
#11
Jiehui Di, Juanjuan Tang, Heya Qian, Derek A Franklin, Chad Deisenroth, Yoko Itahana, Junnian Zheng, Yanping Zhang
The tumor suppressor p53 plays a pivotal role in numerous cellular responses as it regulates cell proliferation, metabolism, cellular growth, and autophagy. In order to identify novel p53 target genes, we utilized an unbiased microarray approach and identified Rap2B as a robust candidate, which belongs to the Ras-related GTP-binding protein superfamily and exhibits increased expression in various human cancers. We demonstrated that p53 increases the intracellular IP3 and Ca(2+) levels and decreases the LC3 protein levels through its target gene Rap2B, suggesting that p53 can inhibit the autophagic response triggered by starvation via upregulation of the Rap2B-PLCε-IP3-Ca(2+) pathway...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027857/is-there-added-value-in-obtaining-cervical-spine-mri-in-the-assessment-of-nontraumatic-angiographically-negative-subarachnoid-hemorrhage-a-retrospective-study-and-meta-analysis-of-the-literature
#12
Gelareh Sadigh, Chad A Holder, Jeffrey M Switchenko, Seena Dehkharghani, Jason W Allen
OBJECTIVE Diagnostic algorithms for nontraumatic angiographically negative subarachnoid hemorrhage (AN-SAH) vary, and the optimal method remains subject to debate. This study assessed the added value of cervical spine MRI in identifying a cause for nontraumatic AN-SAH. METHODS Consecutive patients 18 years of age or older who presented with nontraumatic SAH between February 1, 2009, and October 31, 2014, with negative cerebrovascular catheter angiography and subsequent cervical MRI were studied. Patients with intraparenchymal, subdural, or epidural hemorrhage; recent trauma; or known vascular malformations were excluded...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29026726/hand-grip-strength-and-gender-allometric-normalization-in-older-adults-and-implications-for-the-niosh-lifting-equation
#13
Trish Gail Sevene, Joseph Berning, Chad Harris, Mike Climstein, Kent Jason Adams, Mark DeBeliso
BACKGROUND: Many countries are experiencing an aging workforce with women workers making up a growing proportion. Workplaces often require employees to complete lifting tasks that require the ability of the hand to grasp an implement (coupling). The National Institute for Occupational Safety and Health (NIOSH) has developed an equation for manual lifting tasks hoping to minimize the potential for a workplace back-injury related to a lifting task. The NIOSH lifting equation relies upon stress variables including a coupling factor...
July 2017: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/29021993/multisite-concordance-of-apparent-diffusion-coefficient-measurements-across-the-nci-quantitative-imaging-network
#14
David C Newitt, Dariya Malyarenko, Thomas L Chenevert, C Chad Quarles, Laura Bell, Andriy Fedorov, Fiona Fennessy, Michael A Jacobs, Meiyappan Solaiyappan, Stefanie Hectors, Bachir Taouli, Mark Muzi, Paul E Kinahan, Kathleen M Schmainda, Melissa A Prah, Erin N Taber, Christopher Kroenke, Wei Huang, Lori R Arlinghaus, Thomas E Yankeelov, Yue Cao, Madhava Aryal, Yi-Fen Yen, Jayashree Kalpathy-Cramer, Amita Shukla-Dave, Maggie Fung, Jiachao Liang, Michael Boss, Nola Hylton
Diffusion weighted MRI has become ubiquitous in many areas of medicine, including cancer diagnosis and treatment response monitoring. Reproducibility of diffusion metrics is essential for their acceptance as quantitative biomarkers in these areas. We examined the variability in the apparent diffusion coefficient (ADC) obtained from both postprocessing software implementations utilized by the NCI Quantitative Imaging Network and online scan time-generated ADC maps. Phantom and in vivo breast studies were evaluated for two ([Formula: see text]) and four ([Formula: see text]) [Formula: see text]-value diffusion metrics...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29020744/fastbma-scalable-network-inference-and-transitive-reduction
#15
Ling-Hong Hung, Kaiyuan Shi, Migao Wu, William Chad Young, Adrian E Raftery, Ka Yee Yeung
Inferring genetic networks from genome-wide expression data is extremely demanding computationally. We have developed fastBMA, a distributed, parallel, and scalable implementation of Bayesian model averaging (BMA) for this purpose. fastBMA also includes a computationally efficient module for eliminating redundant indirect edges in the network by mapping the transitive reduction to an easily solved shortest-path problem. We evaluated the performance of fastBMA on synthetic data and experimental genome-wide time series yeast and human datasets...
October 1, 2017: GigaScience
https://www.readbyqxmd.com/read/29018584/affordability-of-comprehensive-community-health-worker-programmes-in-rural-sub-saharan-africa
#16
Celia Taylor, Frances Griffiths, Richard Lilford
INTRODUCTION: Community health worker (CHW) programmes have low costs per person served and are central to achieving universal healthcare. However, their total cost is high and the target of one million CHWs for sub-Saharan Africa by 2015 was not met. We consider the affordability of rural CHW programmes by estimating total programme costs relative to national healthcare expenditure at different CHW salaries and resources available for healthcare. METHODS: We combine an existing source of rural CHW programme costs with World Bank data to estimate relative CHW programme costs in 37 countries...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29017969/vigorous-exercise-mobilizes-cd34-hematopoietic-stem-cells-to-peripheral-blood-via-the-%C3%AE-2-adrenergic-receptor
#17
Nadia H Agha, Forrest L Baker, Hawley E Kunz, Rachel Graff, Rod Azadan, Chad Dolan, Mitzi S Laughlin, Chitra Hosing, Melissa M Markofski, Richard A Bond, Catherine M Bollard, Richard J Simpson
Acute dynamic exercise mobilizes CD34+ hematopoietic stem cells (HSCs) to the bloodstream, potentially serving as an economical adjuvant to boost the collection of HSCs from stem cell transplant donors. The mechanisms responsible for HSC mobilization with exercise are unknown but are likely due to hemodynamic perturbations, endogenous granulocyte-colony stimulating factor (G-CSF), and/or β2-adrenergic receptor (β2-AR) signaling. We characterized the temporal response of HSC mobilization and plasma G-CSF following exercise, and determined the impact of in vivo β-AR blockade on the exercise-induced mobilization of HSCs...
October 7, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28994888/treatment-of-inguinal-hernia-by-lichtenstein-technique-an-open-prospective-study
#18
Imen Samaali, Hachem Hakim Zenaidi, Wejih Dougaz, Mehdi Khalfallah, Hichem Jarraya, Ramzi Nouira, Ibtissem Bouasker, Chadli Dziri
BACKGROUND: Treatment of inguinal hernia is still a challenge for the surgeon. The multitude of surgical techniques attests of the difficulty of choosing the best procedure. In the surgical B department of the Charles Nicolle Hospital we have chosen the Lichtenstein technique since 2008. The aim of this study was to evaluate the immediate and long-term results of this technique and to identify the predictive factors of recurrence. METHODS: This open prospective study included all patients who underwent an elective inguinal hernia repair in the surgical B department of the Charles Nicolle Hospital between June 1st 2008 and December 31st 2009...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28992161/the-role-of-patient-perception-of-crowding-in-the-determination-of-real-time-patient-satisfaction-at-emergency-department
#19
Hao Wang, Jeffrey A Kline, Bradford E Jackson, Richard D Robinson, Matthew Sullivan, Marcus Holmes, Katherine A Watson, Chad D Cowden, Jessica Laureano Phillips, Chet D Schrader, JoAnna Leuck, Nestor R Zenarosa
Objective: To evaluate the associations between real-time overall patient satisfaction and Emergency Department (ED) crowding as determined by patient percepton and crowding estimation tool score in a high-volume ED. Design: A prospective observational study. Setting: A tertiary acute hospital ED and a Level 1 trauma center. Participants: ED patients. Intervention(s): Crowding status was measured by two crowding tools [National Emergency Department Overcrowding Scale (NEDOCS) and Severely overcrowded-Overcrowded-Not overcrowded Estimation Tool (SONET)] and patient perception of crowding surveys administered at discharge...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28983220/similar-cost-savings-of-bundled-payment-initiatives-applied-to-lower-extremity-total-joint-arthroplasty-can-be-achieved-applying-both-models-2-and-3
#20
Allyson Alfonso, Lorraine Hutzler, Bill Robb, Chad Beste, André Blom, Joseph Bosco
BACKGROUND: In an effort to control cost and increase value, Medicare is transitioning from fee-for-service to value-based alternative payment models (APMs). The Bundled Payments for Care Improvement (BPCI) initiative represents one such voluntary APM. BPCI offers four different bundling options: model 1 covers all Diagnosis Related Groups (DRGs) and Models 2-4 cover 48 clinical episodes, including 186 separate DRGs. QUESTIONS/PURPOSES: The purpose of this investigation is to analyze and compare the cost savings achieved by two different BPCI program participants, provider A and provider B, enrolled in different models of BPCI (Models 2 and 3) for lower extremity joint replacements (LEJRs)...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
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