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https://www.readbyqxmd.com/read/29232272/relative-effects-of-age-race-and-stage-on-mortality-in-gestational-choriocarcinoma
#1
Christopher M Tarney, Chunqiao Tian, Eric R Craig, Barbara A Crothers, John K Chan, Glenn D Gist, Nicholas W Bateman, Thomas P Conrads, Chad A Hamilton, George Larry Maxwell, Kathleen M Darcy
OBJECTIVE: Gestational choriocarcinoma is a malignant form of gestational trophoblastic disease that usually arises after a molar pregnancy, but may follow any antecedent pregnancy. Investigations in this rare cancer are limited. We evaluated the prognostic effects of age, race, and stage in choriocarcinomas diagnosed for 4 decades. METHODS: Patients diagnosed as having gestational choriocarcinoma between 1973 and 2014 from the Surveillance, Epidemiology, and End Results program were eligible...
December 11, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29229824/molecular-mechanism-for-the-subversion-of-the-retromer-coat-by-the-legionella-effector-ridl
#2
Miguel Romano-Moreno, Adriana L Rojas, Chad D Williamson, David C Gershlick, María Lucas, Michail N Isupov, Juan S Bonifacino, Matthias P Machner, Aitor Hierro
Microbial pathogens employ sophisticated virulence strategies to cause infections in humans. The intracellular pathogen Legionella pneumophila encodes RidL to hijack the host scaffold protein VPS29, a component of retromer and retriever complexes critical for endosomal cargo recycling. Here, we determined the crystal structure of L. pneumophila RidL in complex with the human VPS29-VPS35 retromer subcomplex. A hairpin loop protruding from RidL inserts into a conserved pocket on VPS29 that is also used by cellular ligands, such as Tre-2/Bub2/Cdc16 domain family member 5 (TBC1D5) and VPS9-ankyrin repeat protein for VPS29 binding...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29227094/synthesis-and-electronic-properties-of-fluoreno-2-1-a-fluorenedione-and-fluoreno-1-2-a-fluorenedione
#3
Allison S Hacker, Mauricio Pavano, James E Wood, Chad E Immoos, Hannah Hashimoto, Sam P Genis, Derik K Frantz
The [2,1-a]- and [1,2-a]-isomers of fluorenofluorenedione have been synthesized via intramolecular Friedel-Crafts acylations. DFT calculations indicate that the [1,2-a]-isomer adopts a twisted, helical C2-symmetric structure and that its protonated form is the thermodynamic product of the Friedel-Crafts acylation in hot sulfuric acid. Absorption spectroscopy and cyclic voltammetry measurements provide experimental estimations of frontier molecular orbital energy levels, which are reported and discussed.
December 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29225952/thirty-year-trends-in-the-prevalence-and-severity-of-female-genital-mutilation-a-comparison-of-22-countries
#4
Alissa Koski, Jody Heymann
Introduction: Female genital mutilation (FGM) harms women's health and well-being and is widely considered a violation of human rights. The United Nations has called for elimination of the practice by 2030. Methods: We used household survey data to measure trends in the prevalence of FGM in 22 countries. We also examined trends in the severity of the practice by measuring changes in the prevalence of flesh removal, infibulation and symbolic 'nicking' of the genitals...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29222816/shyness-and-trajectories-of-functional-network-connectivity-over-early-adolescence
#5
Chad M Sylvester, Diana J Whalen, Andy C Belden, Shana L Sanchez, Joan L Luby, Deanna M Barch
High shyness during early adolescence is associated with impaired peer relationships and risk for psychiatric disorders. Little is known, however, about the relation between shyness and trajectories of brain development over early adolescence. The current study longitudinally examined trajectories of resting-state functional connectivity (rs-fc) within four brain networks in 147 adolescents. Subjects underwent functional magnetic resonance imaging at three different time points, at average ages 10.5 (range = 7...
December 8, 2017: Child Development
https://www.readbyqxmd.com/read/29217374/modern-contraceptive-use-unmet-need-and-demand-satisfied-among-women-of-reproductive-age-who-are-married-or-in-a-union-in-the-focus-countries-of-the-family-planning-2020-initiative-a-systematic-analysis-using-the-family-planning-estimation-tool
#6
Niamh Cahill, Emily Sonneveldt, John Stover, Michelle Weinberger, Jessica Williamson, Chuchu Wei, Win Brown, Leontine Alkema
BACKGROUND: The London Summit on Family Planning in 2012 inspired the Family Planning 2020 (FP2020) initiative and the 120×20 goal of having an additional 120 million women and adolescent girls become users of modern contraceptives in 69 of the world's poorest countries by the year 2020. Working towards achieving 120 × 20 is crucial for ultimately achieving the Sustainable Development Goals of universal access and satisfying demand for reproductive health. Thus, a performance assessment is required to determine countries' progress...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29216028/progress-toward-global-eradication-of-dracunculiasis-january-2016-june-2017
#7
Donald R Hopkins, Ernesto Ruiz-Tiben, Mark L Eberhard, Sharon L Roy, Adam J Weiss
Dracunculiasis (Guinea worm disease) is caused by Dracunculus medinensis, a parasitic worm. Approximately 1 year after a person acquires infection from contaminated drinking water, the worm emerges through the skin, usually on a lower limb (1). Pain and secondary bacterial infection can cause temporary or permanent disability that disrupts work and schooling. The campaign to eradicate dracunculiasis worldwide began in 1980 at CDC. In 1986, the World Health Assembly called for dracunculiasis elimination,* and the global Guinea Worm Eradication Program, led by the Carter Center and supported by the World Health Organization (WHO), United Nations Children's Fund, CDC, and other partners, began assisting ministries of health in countries with endemic dracunculiasis...
December 8, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29214208/eye-movement-feedback-fails-to-improve-visual-search-performance
#8
Chad Peltier, Mark W Becker
Many real-world searches (e.g., radiology and baggage screening) have rare targets. When targets are rare, observers perform rapid, incomplete searches, leading to higher miss rates. To improve search for rare (10% prevalence) targets, we provided eye movement feedback (EMF) to observers during their searches. Although the nature of the EMF varied across experiments, each method informed observers about the regions of the display that had not yet been inspected. We hypothesized that feedback would help guide attention to unsearched areas and increase the proportion of the display searched before making a target-absent response, thereby increasing accuracy...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29209539/proposing-development-and-utility-of-a-mobility-composite-measure-in-patients-with-a-neurologic-disorder
#9
Chad Swank, Sattam Almutairi, Ann Medley
Background: Outcome measures typically assess single domains making holistic assessment difficult. Our purpose was to develop a mobility composite measure (MCM) based on four commonly used outcome measures and compare this composite score to the individual measures in patients with neurologic disorders. Methods: We retrospectively reviewed 148 medical records for inclusion of primary neurologic diagnosis and scoring for 5 times sit-to-stand test (5TSST), 10-meter walk test (10MWT), 2-minute walk test (2MWT), and activities-specific balance confidence (ABC) scale...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/29204651/whole-exome-sequencing-in-adults-with-chronic-kidney-disease-a-pilot-study
#10
Sneh Lata, Maddalena Marasa, Yifu Li, David A Fasel, Emily Groopman, Vaidehi Jobanputra, Hila Rasouly, Adele Mitrotti, Rik Westland, Miguel Verbitsky, Jordan Nestor, Lindsey M Slater, Vivette D'Agati, Marcin Zaniew, Anna Materna-Kiryluk, Francesca Lugani, Gianluca Caridi, Luca Rampoldi, Aditya Mattoo, Chad A Newton, Maya K Rao, Jai Radhakrishnan, Wooin Ahn, Pietro A Canetta, Andrew S Bomback, Gerald B Appel, Corinne Antignac, Glen S Markowitz, Christine K Garcia, Krzysztof Kiryluk, Simone Sanna-Cherchi, Ali G Gharavi
Background: The utility of whole-exome sequencing (WES) for the diagnosis and management of adult-onset constitutional disorders has not been adequately studied. Genetic diagnostics may be advantageous in adults with chronic kidney disease (CKD), in whom the cause of kidney failure often remains unknown. Objective: To study the diagnostic utility of WES in a selected referral population of adults with CKD. Design: Observational cohort. Setting: A major academic medical center...
December 5, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29203521/persistent-opioid-use-among-pediatric-patients-after-surgery
#11
Calista M Harbaugh, Jay S Lee, Hsou Mei Hu, Sean Esteban McCabe, Terri Voepel-Lewis, Michael J Englesbe, Chad M Brummett, Jennifer F Waljee
BACKGROUND: Despite efforts to reduce nonmedical opioid misuse, little is known about the development of persistent opioid use after surgery among adolescents and young adults. We hypothesized that there is an increased incidence of prolonged opioid refills among adolescents and young adults who received prescription opioids after surgery compared with nonsurgical patients. METHODS: We performed a retrospective cohort study by using commercial claims from the Truven Health Marketscan research databases from January 1, 2010, to December 31, 2014...
December 4, 2017: Pediatrics
https://www.readbyqxmd.com/read/29202264/is-augmentation-required-to-correct-malar-deficiency-with-maxillary-advancement
#12
Chad Petersen, Michael R Markiewicz, Michael Miloro
PURPOSE: Patients with maxillary hypoplasia also have malar deficiency; therefore, planning can include consideration for simultaneous malar augmentation. The purpose of this study was to compare pre- and postoperative profiles of patients who underwent Le Fort I advancement, with and without malar augmentation, to assess the subjective perception of changes in malar eminence projection. MATERIALS AND METHODS: Patients who had maxillary advancement and mandibular setback with and without malar augmentation were evaluated through a survey consisting of pre- and postoperative photographs that were assessed by professionals and laypersons, and a visual analog scale was used to assess the malar region...
November 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29198301/the-mslt-is-repeatable-in-narcolepsy-type-1-but-not-narcolepsy-type-2-a-retrospective-patient-study
#13
Chad Ruoff, Fabio Pizza, Lynn Marie Trotti, Karel Sonka, Stefano Vandi, Joseph Cheung, Swaroop Pinto, Mali Einen, Narong Simakajornboon, Fang Han, Paul Peppard, Sona Nevsimalova, Giuseppe Plazzi, David Rye, Emmanuel Mignot
STUDY OBJECTIVES: To examine repeatability of Multiple Sleep Latency Test (MSLT) results in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) according to the criteria of the International Classification of Sleep Disorders, Third Edition (ICSD-3). METHODS: Repeatability of the MSLT was retrospectively evaluated in NT1 (n = 60) and NT2 (n = 54) cases, and controls (n = 15). All subjects had documented HLA-DQB1*06:02 status and/or hypocretin-1 levels from cerebrospinal fluid...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29197811/physical-examination-of-dizziness-in-athletes-after-a-concussion-a-descriptive-study
#14
Jennifer C Reneker, Vinay K Cheruvu, Jingzhen Yang, Mark A James, Chad E Cook
BACKGROUND: Dizziness is commonly reported after concussion. With the forces experienced at the time of the injury, several anatomical locations may have been altered, causing dizziness. OBJECTIVE: Describe an objective examination and the types of impairment/dysfunction implicated by the results of clinical examination tests in subjects with dizziness after a concussion. DESIGN: Cross-Sectional. METHODS: Athletes between ages 10-23 were enrolled with a diagnosis of concussion...
November 26, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29197234/identifying-risk-factors-for-first-episode-neck-pain-a-systematic-review
#15
REVIEW
Rebecca Kim, Colin Wiest, Kelly Clark, Chad Cook, Maggie Horn
Neck pain affects 15.1% of the United States' general population every 3 months, and ranks fourth in global disability. Because of the tendency for neck pain to become a chronic issue, it is important to identify risk factors that could encourage prevention and early diagnosis. The purpose of this systematic review was to identify risk factors for a first episode of neck pain. Three databases were searched with key words such as "neck pain" and "first incidence." Risk factors from the resulting articles were reported as either a physical or psychosocial risk factor and ranked by the strength of their odds/risk/hazard ratio: <1...
November 22, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29187916/-epidemiological-clinical-and-therapeutic-aspects-of-blunt-abdominal-trauma-in-patients-undergoing-surgery-at-the-general-hospital-of-national-reference-of-n-djamena-chad-about-49-cases
#16
Ouchemi Choua, Kimassoum Rimtebaye, Ngueidjo Yamingue, Kalli Moussa, Mignagnal Kaboro
Introduction: Blunt abdominal traumas are common. Methods: We retrospectively reviewed the medical records of 49 patients with blunt abdominal trauma who underwent surgery at the General Hospital of National Reference of N'Djamena, Chad over a period of 5 years. Epidemiological, clinical and therapeutic parameters of patients were studied. Results: The study included 42 men and 7 women, mean age 21.3 years. The causes of blunt abdominal traumas were: road traffic accidents in 61...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29183160/daily-spirometry-in-an-acute-exacerbation-of-adult-cystic-fibrosis-patients
#17
Michael J Stephen, Alex Long, Chad Bonsall, Jeffrey B Hoag, Smita Shah, Dorothy Bisberg, Douglas Holsclaw, Laurie Varlotta, Stan Fiel, Doantrang Du, Robert Zanni, Denis Hadjiliadis
To help answer the question of length of intravenous antibiotics during an acute exacerbation of cystic fibrosis (CF), we had subjects to follow daily home spirometry while on intravenous antibiotics. CF patients, 18 and older, with an acute exacerbation requiring intravenous antibiotics had a daily FEV1. The average time to a 10% increase over their initial sick FEV1 was calculated, as well as the time to a new baseline. A total of 25 subjects completed the study. Ten of the 25 subjects did not have a sustainable 10% increase in FEV1...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29176816/a-large-outbreak-of-hepatitis-e-virus-genotype-1-infection-in-an-urban-setting-in-chad-likely-linked-to-household-level-transmission-factors-2016-2017
#18
Alexander Spina, Annick Lenglet, David Beversluis, Marja de Jong, Larissa Vernier, Craig Spencer, Fred Andayi, Charity Kamau, Simone Vollmer, Boris Hogema, Andrea Irwin, Roger Ngueremi Yary, Açyl Mahamat Ali, Ali Moussa, Prince Alfani, Sibylle Sang
BACKGROUND: In September 2016, three acutely jaundiced (AJS) pregnant women were admitted to Am Timan Hospital, eastern Chad. We described the outbreak and conducted a case test-negative study to identify risk factors for this genotype of HEV in an acute outbreak setting. METHODS: Active case finding using a community based surveillance network identified suspected AJS cases. Pregnant or visibly ill AJS cases presenting at hospital were tested with Assure® IgM HEV rapid diagnostic tests (RDTs) and some with Polymerase Chain Reaction (PCR) in Amsterdam; confirmed cases were RDT-positive and controls were RDT-negative...
2017: PloS One
https://www.readbyqxmd.com/read/29176408/prescription-opioid-use-among-opioid-naive-women-undergoing-immediate-breast-reconstruction
#19
Daniel P Marcusa, Rachel A Mann, David C Cron, Brooklyn R Fillinger, Alexandra K Rzepecki, Jeffrey H Kozlow, Adeyiza Momoh, Michael Englesbe, Chad Brummett, Jennifer F Waljee
BACKGROUND: Cancer patients may be particularly vulnerable to the deleterious effects of prolonged opioid use. The authors explored the factors that influence postoperative opioid prescription fills among women following postmastectomy reconstruction. METHODS: Using the Truven Health MarketScan Research Databases, the authors identified a cohort of 4113 opioid-naive patients undergoing mastectomy and immediate breast reconstruction between January of 2010 and August of 2014...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29174273/placentophagy-s-effects-on-mood-bonding-and-fatigue-a-pilot-trial-part-2
#20
Sharon M Young, Laura K Gryder, Chad Cross, David Zava, David W Kimball, Daniel C Benyshek
BACKGROUND: Human maternal placentophagy is gaining popularity among a growing number of women who believe it provides maternal benefits, including prevention of postpartum blues/depression, improved maternal bonding, and reduced fatigue. METHODS: We conducted a randomized, double-blind, placebo-controlled pilot study (N=27) in which participants consumed either their processed, encapsulated placenta (n=12), or similarly prepared placebo (n=15). Maternal mood, bonding, and fatigue were assessed via validated scales across four time points during late pregnancy and early postpartum...
November 23, 2017: Women and Birth: Journal of the Australian College of Midwives
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