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https://www.readbyqxmd.com/read/29444283/designing-risk-prediction-models-for-ambulatory-no-shows-across-different-specialties-and-clinics
#1
Xiruo Ding, Ziad F Gellad, Chad Mather, Pamela Barth, Eric G Poon, Mark Newman, Benjamin A Goldstein
Objective: As available data increases, so does the opportunity to develop risk scores on more refined patient populations. In this paper we assessed the ability to derive a risk score for a patient no-showing to a clinic visit. Methods: Using data from 2 264 235 outpatient appointments we assessed the performance of models built across 14 different specialties and 55 clinics. We used regularized logistic regression models to fit and assess models built on the health system, specialty, and clinic levels...
February 9, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29443647/system-level-health-care-integration-and-the-costs-of-cancer-care-across-the-disease-continuum
#2
Deborah R Kaye, Hye Sung Min, Edward C Norton, Zaojun Ye, Jonathan Li, James M Dupree, Chad Ellimoottil, David C Miller, Lindsey A Herrel
PURPOSE: Policy reforms in the Affordable Care Act encourage health care integration to improve quality and lower costs. We examined the association between system-level integration and longitudinal costs of cancer care. METHODS: We used linked SEER-Medicare data to identify patients age 66 to 99 years diagnosed with prostate, bladder, esophageal, pancreatic, lung, liver, kidney, colorectal, breast, or ovarian cancer from 2007 to 2012. We attributed each patient to one or more phases of care (ie, initial, continuing, and end of life) according to time from diagnosis until death or end of study interval...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29443067/high-resolution-respirometry-to-measure-mitochondrial-function-of-intact-beta-cells-in-the-presence-of-natural-compounds
#3
Kyle B Kener, Devin J Munk, Chad R Hancock, Jeffery S Tessem
High-resolution respirometry allows for the measurement of oxygen consumption of isolated mitochondria, cells and tissues. Beta cells play a critical role in the body by controlling blood glucose levels through insulin secretion in response to elevated glucose concentrations. Insulin secretion is controlled by glucose metabolism and mitochondrial respiration. Therefore, measuring intact beta cell respiration is essential to be able to improve beta cell function as a treatment for diabetes. Using intact 832/13 INS-1 derived beta cells we can measure the effect of increasing glucose concentration on cellular respiration...
January 23, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29439727/correction-to-adolescent-coordinated-transition-act-to-improve-health-outcomes-among-young-people-living-with-hiv-in-nigeria-study-protocol-for-a-randomized-controlled-trial
#4
Nadia A Sam-Agudu, Jennifer R Pharr, Tamara Bruno, Chad L Cross, Llewellyn J Cornelius, Prosper Okonkwo, Bolanle Oyeledun, Hadiza Khamofu, Ayodotun Olutola, Salome Erekaha, William Nii Ayitey Menson, Echezona E Ezeanolue
In the original publication [1] the figure captions of Figs. 2 and 3 were reversed. The correct version can be found in this Erratum.
February 13, 2018: Trials
https://www.readbyqxmd.com/read/29432322/acute-compartment-syndrome-an-expert-survey-of-orthopedic-trauma-association-ota-members
#5
Cory Collinge, Basem Attum, Paul Tornetta, William Obremskey, Jaimo Ahn, Gudrun Mirick, Andrew Schmidt, Clay Spitler, Chad Coles, Peter Krause
OBJECTIVES: The goal of this study was to describe current opinions of orthopedic trauma experts regarding acute compartment syndrome (ACS). DESIGN: Web-based survey SETTING:: N/A PARTICIPANTS:: Active Orthopedic Trauma Association (OTA) members METHODS:: A 25 item web-based questionnaire was advertised to active members of the OTA. Using a cross-sectional survey study design, we evaluated the perceived importance of ACS, as well as preferences in diagnosis and treatment...
January 24, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29429882/mepivacaine-spinal-anesthesia-facilitates-rapid-recovery-in-total-knee-arthroplasty-compared-to-bupivacaine
#6
M Chad Mahan, Toufic R Jildeh, Troy N Tenbrunsel, Jason J Davis
BACKGROUND: Mepivacaine as a spinal anesthetic for rapid recovery in total knee arthroplasty (TKA) has not been assessed. The purpose of this study is to compare spinal mepivacaine vs bupivacaine for postoperative measures in patients undergoing primary TKA. METHODS: Retrospective review of a prospectively collected single-institution database was performed on 156 consecutive patients who underwent primary TKA. Fifty-three patients were administered mepivacaine and 103 patients were administered bupivacaine...
January 16, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29427520/comprehensive-review-of-genetic-factors-contributing-to-head-and-neck-squamous-cell-carcinoma-development-in-low-risk-nontraditional-patients
#7
Morgan A Gingerich, Joshua D Smith, Nicole L Michmerhuizen, Megan Ludwig, Samantha Devenport, Chloe Matovina, Chad Brenner, Steven B Chinn
BACKGROUND: The past 2 decades have seen an increased incidence of head and neck squamous cell carcinoma (HNSCC) in a nontraditional, low-risk patient population (ie, ≤45 years of age, no substance use history), owing to a combination of human papillomavirus (HPV) infection and individual genetic variation. METHODS: Articles positing genetic variants as contributing factors in HNSCC incidence in low-risk, nontraditional patients were identified using a PubMed search, reviewed in detail, and concisely summarized herein...
February 10, 2018: Head & Neck
https://www.readbyqxmd.com/read/29427231/acceptability-of-peer-delivered-hiv-testing-and-counselling-among-men-who-have-sex-with-men-msm-and-transgender-women-tw-in-myanmar
#8
Vanessa Veronese, Zaw Min Oo, Zaw Win Thein, Poe Poe Aung, Bridget L Draper, Chad Hughes, Claire Ryan, Alisa Pedrana, Mark Stoové
Men who have sex with men (MSM) and transgender women (TW) are a priority population for HIV prevention in Myanmar but report sub-optimal HIV testing frequency. Previous studies have shown that peer involvement in HIV testing can normalize stigmatized sexualities and reduce barriers to testing. We explored the acceptability of peer-delivered HIV testing among 425 undiagnosed MSM and TW in Yangon and Mandalay. An overwhelming majority of participants (86%) reported being 'comfortable/very comfortable' with peer-delivered HIV testing...
February 9, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29423443/demonstration-of-universal-parametric-entangling-gates-on-a-multi-qubit-lattice
#9
Matthew Reagor, Christopher B Osborn, Nikolas Tezak, Alexa Staley, Guenevere Prawiroatmodjo, Michael Scheer, Nasser Alidoust, Eyob A Sete, Nicolas Didier, Marcus P da Silva, Ezer Acala, Joel Angeles, Andrew Bestwick, Maxwell Block, Benjamin Bloom, Adam Bradley, Catvu Bui, Shane Caldwell, Lauren Capelluto, Rick Chilcott, Jeff Cordova, Genya Crossman, Michael Curtis, Saniya Deshpande, Tristan El Bouayadi, Daniel Girshovich, Sabrina Hong, Alex Hudson, Peter Karalekas, Kat Kuang, Michael Lenihan, Riccardo Manenti, Thomas Manning, Jayss Marshall, Yuvraj Mohan, William O'Brien, Johannes Otterbach, Alexander Papageorge, Jean-Philip Paquette, Michael Pelstring, Anthony Polloreno, Vijay Rawat, Colm A Ryan, Russ Renzas, Nick Rubin, Damon Russel, Michael Rust, Diego Scarabelli, Michael Selvanayagam, Rodney Sinclair, Robert Smith, Mark Suska, Ting-Wai To, Mehrnoosh Vahidpour, Nagesh Vodrahalli, Tyler Whyland, Kamal Yadav, William Zeng, Chad T Rigetti
We show that parametric coupling techniques can be used to generate selective entangling interactions for multi-qubit processors. By inducing coherent population exchange between adjacent qubits under frequency modulation, we implement a universal gate set for a linear array of four superconducting qubits. An average process fidelity of ℱ = 93% is estimated for three two-qubit gates via quantum process tomography. We establish the suitability of these techniques for computation by preparing a four-qubit maximally entangled state and comparing the estimated state fidelity with the expected performance of the individual entangling gates...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29421665/inhaled-hexadecyl-treprostinil-provides-pulmonary-vasodilator-activity-at-significantly-lower-plasma-concentrations-than-infused-treprostinil
#10
Richard W Chapman, Zhili Li, Michel R Corboz, Helena Gauani, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Charles E Laurent, Han Yin, Dany Salvail, Chad Dziak, Walter R Perkins, Vladimir Malinin
INS1009 is a long acting pulmonary vasodilator prodrug of treprostinil (TRE) that is formulated in a lipid nanoparticle for inhaled delivery by nebulization. This study examined the ability of INS1009 to inhibit vasoconstriction in the pulmonary vasculature of rats and dogs and the extent to which local activity within the lung contributes to its activity. Rats received a single dose of INS1009 by nose-only inhalation or were given a continuous intravenous (i.v.) infusion of TRE, followed by an i.v. challenge of the thromboxane mimetic pulmonary vasoconstrictor U46619 and the increase in pulmonary arterial pressure (PAP) was measured...
February 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29409745/association-of-non-immediate-drug-hypersensitivity-with-drug-exposure-a-case-control-analysis-of-spontaneous-reports-from-a-tunisian-pharmacovigilance-database
#11
Amel Chaabane, Najeh Ben Fadhel, Zohra Chadli, Haifa Ben Romdhane, Nadia Ben Fredj, Naceur A Boughattas, Karim Aouam
PURPOSE: To assess delayed-type cutaneous reactions (DTCRs) related to drugs, using a case-control approach to qualify drug risks. METHODS: The study used the Tunisian pharmacovigilance database of Monastir. The association between drugs and DTCRs was assessed using a case/non-case method. Drugs were grouped according to the ATC Classification System. Patients were defined as "cases" if they have developed DTCRs regardless of the causality assessment. All other reports were "non-cases"...
February 3, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29406465/randomized-multicenter-study-comparing-safety-and-efficacy-of-daptomycin-versus-standard-of-care-in-pediatric-patients-with-staphylococcal-bacteremia
#12
Antonio C Arrieta, John S Bradley, Myra W Popejoy, Mekki Bensaci, Anjana Grandhi, Paula Bokesch, Chad Glasser, Lihong Du, Nicholas A Kartsonis
BACKGROUND: Staphylococcus aureus, including community-associated methicillin-resistant S. aureus, is an important cause of pediatric bacteremia. Daptomycin is a well-established treatment option for gram-positive bacteremia in adults, but its safety and efficacy in children require confirmation. METHODS: This was a randomized (2:1), evaluator-blinded, multi-center, phase 4 clinical trial comparing intravenous daptomycin with standard-of-care (SOC) for treatment of S...
February 3, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29404578/quality-of-care-for-veterans-with-transient-ischemic-attack-and-minor-stroke
#13
Dawn M Bravata, Laura J Myers, Greg Arling, Edward J Miech, Teresa Damush, Jason J Sico, Michael S Phipps, Alan J Zillich, Zhangsheng Yu, Mathew Reeves, Linda S Williams, Jason Johanning, Seemant Chaturvedi, Fitsum Baye, Susan Ofner, Curt Austin, Jared Ferguson, Glenn D Graham, Rachel Rhude, Chad S Kessler, Donald S Higgins, Eric Cheng
Importance: The timely delivery of guideline-concordant care may reduce the risk of recurrent vascular events for patients with transient ischemic attack (TIA) and minor stroke. Although many health care organizations measure stroke care quality, few evaluate performance for patients with TIA or minor stroke, and most include only a limited subset of guideline-recommended processes. Objective: To assess the quality of guideline-recommended TIA and minor stroke care across the Veterans Health Administration (VHA) system nationwide...
February 5, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29402501/hoxa4-hoxb3-gene-expression-signature-as-a-biomarker-of-recurrence-in-patients-with-high-grade-serous-ovarian-cancer-following-primary-cytoreductive-surgery-and-first-line-adjuvant-chemotherapy
#14
Katherine R Miller, Jai N Patel, Qing Zhang, Eric J Norris, James Symanowski, Chad Michener, Jalid Sehouli, Ioana Braicu, Darla D Destephanis, Ashley P Sutker, Wendell Jones, Chad A Livasy, Charles Biscotti, Ram N Ganapathi, David L Tait, Mahrukh K Ganapathi
OBJECTIVES: Aberrant homeobox (HOX) gene expression is reported in high-grade serous ovarian carcinoma (HGSOC), however, its prognostic significance remains unclear. METHODS: HOX genes associated with progression-free survival (PFS) in a discovery cohort of primary HGSOC samples with RNA sequencing data, and those previously reported to be associated with clinical outcomes, were selected for qPCR testing in an independent training cohort of primary HGSOC samples (n=71)...
February 2, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29402077/trifunctional-high-throughput-screen-identifies-promising-scaffold-to-inhibit-grp94-and-treat-myocilin-associated-glaucoma
#15
Dustin Je Huard, Vincent M Crowley, Yuhong Du, Ricardo A Cordova, Zheying Sun, Moya O Tomlin, Chad A Dickey, John Koren, Laura Blair, Haian Fu, Brian S J Blagg, Raquel L Lieberman
Gain-of-function mutations within the olfactomedin (OLF) domain of myocilin result in its toxic intracellular accumulation and hastens the onset of open-angle glaucoma. The absence of myocilin does not cause disease; therefore, strategies aimed at eliminating myocilin could lead to a successful glaucoma treatment. The endoplasmic reticulum Hsp90 paralog Grp94 accelerates OLF aggregation. Knockdown or pharmacological inhibition of Grp94 in cells facilitates clearance of mutant myocilin via a non-proteasomal pathway...
February 5, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29394960/increased-eeg-theta-spectral-power-in-sleep-in-myotonic-dystrophy-type-1
#16
Joseph Cheung, Chad Ruoff, Hyatt Moore, Katharine A Hagerman, Jennifer Perez, Sarada Sakamuri, Simon C Warby, Emmanuel Mignot, John Day, Jacinda Sampson
STUDY OBJECTIVES: Myotonic dystrophy type 1 (DM1) is a multisystemic disorder that involves the central nervous system (CNS). Individuals with DM1 commonly present with sleep dysregulation, including excessive daytime sleepiness and sleep-disordered breathing. We aim to characterize electroencephalogram (EEG) power spectra from nocturnal polysomnography (PSG) in patients with DM1 compared to matched controls to better understand the potential CNS sleep dysfunction in DM1. METHODS: A retrospective, case-control (1:2) chart review of patients with DM1 (n = 18) and matched controls (n = 36) referred for clinical PSG at the Stanford Sleep Center was performed...
January 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29394102/virtual-sprouts-a-virtual-gardening-pilot-intervention-increases-self-efficacy-to-cook-and-eat-fruits-and-vegetables-in-minority-youth
#17
Brooke M Bell, Lauren Martinez, Marientina Gotsis, H Chad Lane, Jaimie N Davis, Luz Antunez-Castillo, Gisele Ragusa, Donna Spruijt-Metz
OBJECTIVE: To examine the effect of the Virtual Sprouts intervention, an interactive multiplatform mobile gardening game, on dietary intake and psychosocial determinants of dietary behavior in minority youth. MATERIALS AND METHODS: In this quasi-experimental pilot intervention, 180 third-, fourth-, and fifth-grade students in Los Angeles Unified School District participated in a 3-week program that included three Virtual Sprouts gaming sessions, three in-school lessons, and three in-home activities, using a nutrition- and gardening-focused curriculum...
February 2, 2018: Games for Health
https://www.readbyqxmd.com/read/29389444/obese-children-require-lower-doses-of-pantoprazole-than-nonobese-peers-to-achieve-equal-systemic-drug-exposures
#18
Valentina Shakhnovich, P Brian Smith, Jeffrey T Guptill, Laura P James, David N Collier, Huali Wu, Chad E Livingston, Jian Zhao, Gregory L Kearns
OBJECTIVE: To assess appropriate pantoprazole dosing for obese children, we conducted a prospective pharmacokinetics (PK) investigation of pantoprazole in obese children, a patient population that is traditionally excluded from clinical trials. STUDY DESIGN: A total of 41 obese children (6-17 years of age), genotyped for CYP2C19 variants *2, *3, *4, and *17, received a single oral dose of pantoprazole, ~1.2 mg/kg lean body weight (LBW), with LBW calculated via a validated formula...
February 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29383154/an-ultrastructural-investigation-of-tumors-undergoing-regression-mediated-by-immunotherapy
#19
Jennifer A Westwood, Sarah Ellis, Jill Danne, Chad Johnson, Viola Oorschot, Georg Ramm, David C Tscharke, Alexander J Davenport, James C Whisstock, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
While immunotherapy employing chimeric antigen receptor (CAR) T cells can be effective against a variety of tumor types, little is known about what happens within the tumor at an ultrastructural level during tumor regression. Here, we used transmission electron microscopy to investigate morphologic and cellular features of tumors responding to immunotherapy composed of adoptive transfer of dual-specific CAR T cells and a vaccine, supported by preconditioning irradiation and interleukin-2. Tumors responded rapidly, and large areas of cell death were apparent by 4 days after treatment...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29381807/the-facioscapulohumeral-muscular-dystrophy-functional-composite-outcome-measure
#20
Katy Eichinger, Chad Heatwole, Stanley Iyadurai, Wendy King, Lindsay Baker, Susanne Heininger, Amy Bartlett, Nuran Dilek, William B Martens, Michael McDermott, John T Kissel, Rabi Tawil, Jeffrey M Statland
INTRODUCTION: We developed an evaluator-administered functional composite outcome measure (FSHD-COM) comprised of patient-identified areas of functional burden for future clinical trials. METHODS: We performed a prospective observational study of 41 FSHD participants at 2 sites. The FSHD-COM includes functional assessment of the legs, shoulders and arms, trunk, hands, and balance/mobility. We determined the test-retest reliability and convergent validity as compared to established FSHD disease metrics...
January 30, 2018: Muscle & Nerve
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