Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Tanner Smida, James Menegazzi, Remle Crowe, James Scheidler, David Salcido, James Bardes
INTRODUCTION: While various supraglottic airway devices are available for use during out-of-hospital cardiac arrest (OHCA) resuscitation, comparisons of patient outcomes by device are limited. In this study, we aimed to compare outcomes of OHCA patients who had airway management by emergency medical services (EMS) with the iGel or King-LT. METHODS: We used the 2018-2021 ESO Data Collaborative public use research datasets for this retrospective study. All patients with non-traumatic OHCA who had iGels or King-LTs inserted by EMS were included...
February 13, 2023: Prehospital Emergency Care
#22
JOURNAL ARTICLE
Christina Kovar, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E Mürdter, Matthias Schwab, Thorsten Lehr
Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. However, since ( E )-clomiphene (( E )-Clom) and its metabolites are eliminated primarily via Cytochrome P450 (CYP) 2D6 and CYP3A4, exposure can be affected by CYP2D6 polymorphisms and concomitant use with CYP inhibitors. Thus, clomiphene therapy may be susceptible to drug-gene interactions (DGIs), drug-drug interactions (DDIs) and drug-drug-gene interactions (DDGIs). Physiologically based pharmacokinetic (PBPK) modeling is a tool to quantify such DGI and DD(G)I scenarios...
November 25, 2022: Pharmaceutics
#23
JOURNAL ARTICLE
Patrick Bilic, Patrick Christ, Hongwei Bran Li, Eugene Vorontsov, Avi Ben-Cohen, Georgios Kaissis, Adi Szeskin, Colin Jacobs, Gabriel Efrain Humpire Mamani, Gabriel Chartrand, Fabian Lohöfer, Julian Walter Holch, Wieland Sommer, Felix Hofmann, Alexandre Hostettler, Naama Lev-Cohain, Michal Drozdzal, Michal Marianne Amitai, Refael Vivanti, Jacob Sosna, Ivan Ezhov, Anjany Sekuboyina, Fernando Navarro, Florian Kofler, Johannes C Paetzold, Suprosanna Shit, Xiaobin Hu, Jana Lipková, Markus Rempfler, Marie Piraud, Jan Kirschke, Benedikt Wiestler, Zhiheng Zhang, Christian Hülsemeyer, Marcel Beetz, Florian Ettlinger, Michela Antonelli, Woong Bae, Míriam Bellver, Lei Bi, Hao Chen, Grzegorz Chlebus, Erik B Dam, Qi Dou, Chi-Wing Fu, Bogdan Georgescu, Xavier Giró-I-Nieto, Felix Gruen, Xu Han, Pheng-Ann Heng, Jürgen Hesser, Jan Hendrik Moltz, Christian Igel, Fabian Isensee, Paul Jäger, Fucang Jia, Krishna Chaitanya Kaluva, Mahendra Khened, Ildoo Kim, Jae-Hun Kim, Sungwoong Kim, Simon Kohl, Tomasz Konopczynski, Avinash Kori, Ganapathy Krishnamurthi, Fan Li, Hongchao Li, Junbo Li, Xiaomeng Li, John Lowengrub, Jun Ma, Klaus Maier-Hein, Kevis-Kokitsi Maninis, Hans Meine, Dorit Merhof, Akshay Pai, Mathias Perslev, Jens Petersen, Jordi Pont-Tuset, Jin Qi, Xiaojuan Qi, Oliver Rippel, Karsten Roth, Ignacio Sarasua, Andrea Schenk, Zengming Shen, Jordi Torres, Christian Wachinger, Chunliang Wang, Leon Weninger, Jianrong Wu, Daguang Xu, Xiaoping Yang, Simon Chun-Ho Yu, Yading Yuan, Miao Yue, Liping Zhang, Jorge Cardoso, Spyridon Bakas, Rickmer Braren, Volker Heinemann, Christopher Pal, An Tang, Samuel Kadoury, Luc Soler, Bram van Ginneken, Hayit Greenspan, Leo Joskowicz, Bjoern Menze
In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions...
February 2023: Medical Image Analysis
#24
JOURNAL ARTICLE
Willian E Ito, Daniel A Igel, Bristol B Whiles, Mihaela Sardiu, Donald A Neff, David A Duchene, Wilson R Molina
OBJECTIVE: To compare the maintenance costs of digital flexible ureteroscopes (DFU) versus fiberoptic flexible ureteroscopes (FFU) to understand the long-term financial impact associated with breakage in a flexible ureteroscopy (f-URS) program. METHODS: Data for breakage of FFU and DFU at an academic institution from 2019 to 2021 were obtained from our vendor (Karl Storz®) and analyzed by month. Correlation test was used to evaluate significant differences in number of procedures, number of breakage events, breakage rates, and repair cost per month...
November 15, 2022: Urology
#25
REVIEW
Angélique Igel, Basile Fornara, Human Rezaei, Vincent Béringue
Prions are proteinaceous pathogens responsible for a wide range of neurodegenerative diseases in animal and human. Prions are formed from misfolded, ß-sheet rich, and aggregated conformers (PrPSc ) of the host-encoded prion protein (PrPC ). Prion replication stems from the capacity of PrPSc to self-replicate by templating PrPC conversion and polymerization. The question then arises about the molecular mechanisms of prion replication, host invasion, and capacity to contaminate other species. Studying these mechanisms has gained in recent years further complexity with evidence that PrPSc is a pleiomorphic protein...
November 18, 2022: Cell and Tissue Research
#26
JOURNAL ARTICLE
Paula Liang, Katrin Wacker, Günther Schlunck, Hansjürgen Agostini, Bernd Raffelhüschen, Thomas Reinhard, Felicitas Bucher
BACKGROUND: Individual health services (IGeL) enable patients to receive medical services not covered by social health care; however, there is no central data collection on IGeL in Germany. OBJECTIVE: This study illustrates the spectrum of IGeL provided in the field of ophthalmology as an example of the importance of IGeL in Germany based on survey results. MATERIAL AND METHODS: Nationwide, 10% of ophthalmologists in private practice were randomly selected in this anonymous survey in 2010 and 2020 while in 2020 in addition to the randomized 10% of ophthalmologists the same ophthalmologists from 2010 were contacted...
November 4, 2022: Ophthalmologie
#27
JOURNAL ARTICLE
Aaron Shield, Megan Igel, Richard P Meier
Acquisition of pronominal forms by children with autism spectrum disorder (ASD) continues to garner significant attention due to the unusual ways that such children produce and comprehend them. In particular, pronoun reversal errors (e.g., using the 2nd-person pronoun "you" to refer to oneself) have been noted in the speech of children with ASD since the very first report of the disorder. In more recent years, investigations of the signing of deaf children with ASD have documented a different phenomenon: palm orientation reversals, such that signs typically produced with an outward-facing palm are produced with the palm towards the signer, or vice versa...
2022: Frontiers in Psychology
#28
JOURNAL ARTICLE
Babak J Orandi, Chandler McLeod, Rhiannon D Reed, Vineeta Kumar, Leon I Igel, Louis J Aronne, Robert M Cannon, Cora E Lewis, Jayme E Locke
OBJECTIVE: Recent changes to the Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate (eGFR) formula (2021 CKD-EPI) removed race from the 2009 formula, increasing the number of Black people classified as having CKD, but these changes may impact eligibility and/or dosing for antiobesity medications. This study estimated the number of people with obesity nationwide who might have pharmacotherapy options impacted by the new formula. METHODS: Using National Health and Nutrition Examination Survey (NHANES) cohort study data, the number of people eligible for antiobesity medication was estimated, and the number who would require a dosage reduction or would no longer be eligible for specific medications based on the new eGFR formula was also estimated...
September 25, 2022: Obesity
#29
JOURNAL ARTICLE
Simeon Rüdesheim, Dominik Selzer, Thomas Mürdter, Svitlana Igel, Reinhold Kerb, Matthias Schwab, Thorsten Lehr
The cytochrome P450 2D6 ( CYP2D6 ) genotype is the single most important determinant of CYP2D6 activity as well as interindividual and interpopulation variability in CYP2D6 activity. Here, the CYP2D6 activity score provides an established tool to categorize the large number of CYP2D6 alleles by activity and facilitates the process of genotype-to-phenotype translation. Compared to the broad traditional phenotype categories, the CYP2D6 activity score additionally serves as a superior scale of CYP2D6 activity due to its finer graduation...
August 18, 2022: Pharmaceutics
#30
JOURNAL ARTICLE
Judith Rademacher, Hanna Müllner, Torsten Diekhoff, Hildrun Haibel, Sabrina Igel, Dominika Pohlmann, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Uwe Pleyer, Denis Poddubnyy
OBJECTIVE: To analyse the prevalence of spondyloarthritis (SpA) in patients with acute anterior uveitis (AAU), to identify parameters associated with SpA presence, and to evaluate referral algorithms. METHODS: Prospectively recruited consecutive patients with non-infectious AAU underwent structured rheumatologic assessment including magnetic resonance imaging of sacroiliac joints allowing a definitive diagnosis/exclusion of concomitant SpA. Fisher's exact test and Mann-Whitney U test were used to compare AAU patients with and without SpA...
July 29, 2022: Arthritis & Rheumatology
#31
JOURNAL ARTICLE
Bobby Lo, ZhuoYuan Liu, Flemming Bendtsen, Christian Igel, Ida Vind, Johan Burisch
INTRODUCTION: The evaluation of endoscopic disease severity is a crucial component in managing patients with ulcerative colitis (UC). However, endoscopic assessment suffers from substantial intraobserver and interobserver variations, limiting the reliability of individual assessments. Therefore, we aimed to develop a deep learning model capable of distinguishing active from healed mucosa and differentiating between different endoscopic disease severity degrees. METHODS: One thousand four hundred eighty-four unique endoscopic images from 467 patients were extracted for classification...
October 1, 2022: American Journal of Gastroenterology
#32
JOURNAL ARTICLE
Fabio S T Sweet, Thomas Rödl, Wolfgang W Weisser
The COVID-19 pandemic has led to temporary changes in human-animal interactions due to changes in human activities. Here, we report on a surge in hedgehog observations during the first COVID-19 lockdown in Germany in 2020, on the citizen science Web portal "Igel in Bayern" (Hedgehogs in Bavaria) in Germany. This increase in comparison with previous years was attributed to an increase in the number of people reporting hedgehog observations, rather than an increase in the number of hedgehog observations made by each observer...
July 2022: Ecology and Evolution
#33
EDITORIAL
Daniel A Igel, Avi Baskin
No abstract text is available yet for this article.
June 6, 2022: Journal of Urology
#34
JOURNAL ARTICLE
H M Kamrul Hassan, Barbara Igel, Mohammad Shamsuddoha
Social entrepreneurship has received considerable recognition from universities in recent years. This study aimed to examine the mediating effect of the entrepreneurial social network on entrepreneurship education and social entrepreneurial intention (SEI) of students at the university level. This study adopted a cross-sectional quantitative approach. A convenience sampling method was utilized to choose 392 students studying at the public and private universities in Chattogram, Bangladesh, who then completed a self-administered survey...
2022: Frontiers in Psychology
#35
JOURNAL ARTICLE
Helmut Walbert
No abstract text is available yet for this article.
June 2022: MMW Fortschritte der Medizin
#36
REVIEW
Ulrike Igel, Ruth Gausche, Martina Lück, Gesine Grande, Wieland Kiess
Besides individual determinants, obesity is also caused by obesogenic environmental conditions. Thus, prevention of obesity in children should aim at creating health-promoting environments. This is especially important for children of socially disadvantaged families and communities who are hardly reached and often profit less by behavior-oriented interventions. The main question is which environmental conditions should be changed and how in order to be accepted and sustainable? According to our experiences from the project "Grünau moves" ( Grünau bewegt sich ), the consideration of environmental and social conditions in the intervention field as well as the inclusion of the professional expertise of local agents and the lifeworld perspective (subjective meanings and realities) of families and children are crucial...
2022: Monatsschrift Kinderheilkunde: Organ der Deutschen Gesellschaft Für Kinderheilkunde
#37
JOURNAL ARTICLE
Andrew D Bailey, Jason Talkish, Hongxu Ding, Haller A Igel, Alejandra Duran, Shreya Mantripragada, Benedict Paten, Manuel Ares
Nucleotides in RNA and DNA are chemically modified by numerous enzymes that alter their function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations, particularly at highly conserved and functionally important nucleotides. During ribosome biogenesis, modifications are added at various stages of assembly. The existence of differently modified classes of ribosomes in normal cells is unknown because no method exists to simultaneously evaluate the modification status at all sites within a single rRNA molecule...
April 6, 2022: ELife
#38
JOURNAL ARTICLE
Stefano Parmigiani, Giulio Bevilacqua
Non-invasive pulmonary surfactant (SF) administration for neonatal respiratory distress syndrome (NRDS) is a development of administration of SF. Administration of SF via a supraglottic device (SGD) has been shown to be effective. Here the results of administration of SF in NRDS in infants requiring oxygen and nasal-CPAP (n-CPAP) via two types of SGDs, LMA® vs iGel®, in a second level Neonatal Unit are reported in a retrospective study. Results - Fourteen infants in the LMA®Group were matched with 21 comparable infants in the iGel® Group (g...
March 14, 2022: Acta Bio-medica: Atenei Parmensis
#39
RANDOMIZED CONTROLLED TRIAL
D E Ari, S Abitagaoglu, C Koksal, A YildirimAr, D Emrem, M Ustun
AIMS: Comparison of the use of I-gel and Laringeal Mask Airway (LMA) Protector in laparoscopic cholecystectomy regarding the time and ease of insertion for supraglottic airway devices (SAD) and gastric tube (GT), airway sealing capacity, and postoperative complications. PATIENTS AND METHODS: Sixty-four American Society of Anaesthesiologists (ASA) I-III patients undergoing laparoscopic cholecystectomy were randomly allocated into two groups. After anesthesia induction, LMA Protector was inserted in Group LPRO (LMA Protector) (n = 33) and I-gel was inserted in Group IGEL (I-gel) (n = 31) patients...
January 2022: Nigerian Journal of Clinical Practice
#40
JOURNAL ARTICLE
Georgios Doulaveris, Catherine M Igel, Fatima Estrada Trejo, Desiree Fiorentino, Sara Rabin-Havt, Susan Klugman, Pe'er Dar
OBJECTIVE: First-trimester ultrasound is an important component of prenatal care. We investigated the impact of introducing cell-free DNA (cfDNA) aneuploidy screening into routine care, on performance of first-trimester ultrasound. METHODS: Retrospective study of patients who had prenatal care at a tertiary referral center. We compared the performance of any first-trimester ultrasound between three different aneuploidy screening protocols, used consecutively during the study period: (1) combined first-trimester screening (FTS); (2) FTS and cfDNA offered together; (3) patients requested to choose between FTS and cfDNA...
February 2022: Prenatal Diagnosis
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
