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Ivayla Apostolova, Catharina Lange, Anna Roberts, Hans Joachim Igel, Anja Mäurer, Stephanie Liese, Melanie Estrella, Vikas Prasad, Elisabeth Stechl, Gernot Lämmler, Elisabeth Steinhagen-Thiessen, Ralph Buchert
BACKGROUND: Neuroimaging-based biomarkers have the potential to improve etiological diagnosis of cognitive impairment in elderly inpatients. However, there is a relative lack of studies on neuroimaging-based biomarkers in hospitalized geriatric patients, as the vast majority of neuroimaging studies in dementia have focused on memory clinic outpatients. An important aspect of study planning is a priori estimation of the rate of screen failures. OBJECTIVE: To report on the rate and causes of screen failures in a prospective study on the utility of neuroimaging (PET, MRI) for the etiological diagnosis of newly manifested cognitive impairment in acutely hospitalized geriatric patients...
November 28, 2016: Journal of Alzheimer's Disease: JAD
Arthur L Caplan, Brendan Parent, Lee H Igel
Years ago, one of us had the opportunity to talk with a starting guard in the National Basketball Association about his health care. The player, then a rookie, did not have his own personal doctor. Instead, he received his health care from the team doctor. This athlete was very well paid and could have received care anywhere he wished in the area. But he came from a very poor neighborhood. Growing up, he said, he had no health care other than hearing and eye tests done at his school and maybe (he was not sure) vaccinations given by the school nurse...
November 2016: Hastings Center Report
Ram A Pathak, Gregory A Broderick, Todd C Igel, Steven P Petrou, Paul R Young, Michael J Wehle, Michael G Heckman, Nancy N Diehl, Emily R Vargas, Kandarp Shah, David D Thiel
OBJECTIVE: To compare the frequency of postoperative encounters in the 30-day and 90-day postoperative periods for various bladder outlet obstruction surgical therapies. METHODS: All patients who underwent transurethral resection of the prostate (TURP), GreenLight laser photovaporization of the prostate (GL-PVP) (American Medical Systems Inc.), and holmium laser enucleation of the prostate (HoLEP) from January 1(st), 2012 through December 31(st), 2014 were followed for 6 months postoperatively...
October 19, 2016: Urology
Katherine H Saunders, Leon I Igel, Louis J Aronne
As the prevalence of obesity continues to increase, the need for effective long-term treatment strategies for the overweight and the obese is critical. Pharmacology fills a large treatment gap between behavioral therapy, which is insufficient for the majority of patients, and devices and surgery, which are available to only a subset of patients. Naltrexone HCl and bupropion HCl Extended-Release (naltrexone XR/bupropion XR) was approved by the Food and Drug Administration for chronic weight management in 2014...
October 4, 2016: Expert Opinion on Pharmacotherapy
Michael Schmucker, Kemal Yildirim, Christoph Igel, Martin Haag
Smart wearables are capable of supporting physicians during various processes in medical emergencies. Nevertheless, it is almost impossible to operate several computers without neglecting a patient's treatment. Thus, it is necessary to set up a distributed network consisting of two or more computers to exchange data or initiate remote procedure calls (RPC). If it is not possible to create flawless connections between those devices, it is not possible to transfer medically relevant data to the most suitable device, as well as to control a device with another one...
2016: Studies in Health Technology and Informatics
Quentin Bourgeois, Annica M L Ekman, Matthew R Igel, Radovan Krejci
Clouds are crucial for Earth's climate and radiation budget. Great attention has been paid to low, high and vertically thick tropospheric clouds such as stratus, cirrus and deep convective clouds. However, much less is known about tropospheric mid-level clouds as these clouds are challenging to observe in situ and difficult to detect by remote sensing techniques. Here we use Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) satellite observations to show that thin mid-level clouds (TMLCs) are ubiquitous in the tropics...
2016: Nature Communications
Katherine H Saunders, Alpana P Shukla, Leon I Igel, Rekha B Kumar, Louis J Aronne
Successful treatment of obesity requires a multidisciplinary approach including diet, exercise and behavioral modification. As lifestyle changes are not sufficient for some patients, pharmacologic therapies should be considered as adjuncts to lifestyle interventions. In this article, we review clinical indications, mechanisms of action, dosing/administration, side effects, drug interactions and contraindications for the six most widely prescribed obesity medications. We also summarize the efficacy data from phase 3 trials which led to drug approval...
September 2016: Endocrinology and Metabolism Clinics of North America
U Igel, M Romppel, J Baar, E Brähler, G Grande
No abstract text is available yet for this article.
July 13, 2016: Public Health
Carola Munoz-Montesino, Christina Sizun, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Jérôme Chapuis, Danica Ciric, Angelique Igel-Egalon, Hubert Laude, Vincent Béringue, Human Rezaei, Michel Dron
UNLABELLED: Mammalian prions are PrP proteins with altered structures causing transmissible fatal neurodegenerative diseases. They are self-perpetuating through formation of beta-sheet-rich assemblies that seed conformational change of cellular PrP. Pathological PrP usually forms an insoluble protease-resistant core exhibiting beta-sheet structures but no more alpha-helical content, loosing the three alpha-helices contained in the correctly folded PrP. The lack of a high-resolution prion structure makes it difficult to understand the dynamics of conversion and to identify elements of the protein involved in this process...
August 1, 2016: Journal of Virology
Katherine H Saunders, Rekha B Kumar, Leon I Igel, Louis J Aronne
Obesity is a growing epidemic in the USA with over one third of adults presently classified as obese. Obesity-related comorbidities include many leading causes of preventable death such as heart disease, stroke, type 2 diabetes, and certain types of cancer. Modest weight loss of 5-10 % of body weight is sufficient to produce clinically relevant improvements in cardiovascular disease risk factors among patients with overweight and obesity. Until recently, there were limited pharmacologic options approved by the Food and Drug Administration to treat obesity...
July 2016: Current Atherosclerosis Reports
Johanna Baar, Matthias Romppel, Ulrike Igel, Elmar Brähler, Gesine Grande
BACKGROUND: A growing body of research has identified an association between health and physical residential environmental characteristics. However, the direction of effects remains unclear, and further research is needed to determine whether the residential environment influences health. OBJECTIVES: To specify the direction of the association between environmental disadvantage and self-reported health. METHODS: Longitudinal data were obtained from the German Socioeconomic Panel and were examined at two points in time...
January 2016: International Journal of Occupational and Environmental Health
Michiel Kallenberg, Kersten Petersen, Mads Nielsen, Andrew Ng, Pengfei Diao, Christian Igel, Celine Vachon, Katharina Holland, Nico Karssemeijer, Martin Lillholm
Mammographic risk scoring has commonly been automated by extracting a set of handcrafted features from mammograms, and relating the responses directly or indirectly to breast cancer risk. We present a method that learns a feature hierarchy from unlabeled data. When the learned features are used as the input to a simple classifier, two different tasks can be addressed: i) breast density segmentation, and ii) scoring of mammographic texture. The proposed model learns features at multiple scales. To control the models capacity a novel sparsity regularizer is introduced that incorporates both lifetime and population sparsity...
February 18, 2016: IEEE Transactions on Medical Imaging
L I Igel, A Sinha, K H Saunders, C M Apovian, D Vojta, L J Aronne
Metformin is not currently used for weight loss or diabetes prevention because it lacks an FDA indication for obesity and/or pre-diabetes treatment. Based on the evidence, metformin has been shown to decrease the incidence of type 2 diabetes, and compares favorably to other weight-loss medications in terms of efficacy as well as safety. Thus, metformin should be considered for a treatment indication in patients with these conditions.
April 2016: Current Atherosclerosis Reports
Lee H Igel, Barron H Lerner
No abstract text is available yet for this article.
January 2016: AMA Journal of Ethics
Lauge Sørensen, Christian Igel, Naja Liv Hansen, Merete Osler, Martin Lauritzen, Egill Rostrup, Mads Nielsen
Cognitive impairment in patients with Alzheimer's disease (AD) is associated with reduction in hippocampal volume in magnetic resonance imaging (MRI). However, it is unknown whether hippocampal texture changes in persons with mild cognitive impairment (MCI) that does not have a change in hippocampal volume. We tested the hypothesis that hippocampal texture has association to early cognitive loss beyond that of volumetric changes. The texture marker was trained and evaluated using T1-weighted MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, and subsequently applied to score independent data sets from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) and the Metropolit 1953 Danish Male Birth Cohort (Metropolit)...
March 2016: Human Brain Mapping
Joan Torrent, Reinhard Lange, Angelique Igel-Egalon, Vincent Béringue, Human Rezaei
The phenomenon of protein superstructural polymorphism has become the subject of increased research activity. Besides the relevance to explain the existence of multiple prion strains, such activity is partly driven by the recent finding that in many age-related neurodegenerative diseases highly ordered self-associated forms of peptides and proteins might be the structural basis of prion-like processes and strains giving rise to different disease phenotypes. Biophysical studies of prion strains have been hindered by a lack of tools to characterize inherently noncrystalline, heterogeneous and insoluble proteins...
2016: Prion
Jeffrey Rogers, Ravi Katari, Sheyna Gifford, Riccardo Tamburrini, Lauren Edgar, Marcia R Voigt, Sean V Murphy, Daniel Igel, Sara Mancone, Tyler Callese, Nicola Colucci, Majid Mirzazadeh, Andrea Peloso, Joao Paulo Zambon, Alan C Farney, Robert J Stratta, Giuseppe Orlando
Kidney transplantation (KT), as a modality of renal replacement therapy (RRT), has been shown to be both economically and functionally superior to dialysis for the treatment of end-stage renal disease (ESRD). Progress in KT is limited by two major barriers: a) a chronic and burgeoning shortage of transplantable organs and b) the need for chronic immunosuppression following transplantation. Although ground-breaking advances in transplant immunology have improved patient survival and graft durability, a new pathway of innovation is needed in order to overcome current obstacles...
February 2016: Expert Review of Clinical Immunology
Ram A Pathak, Abby S Taylor, Scott Alford, Gregory A Broderick, Todd C Igel, Steven P Petrou, Michael J Wehle, Paul R Young, David D Thiel
PURPOSE: A prophylactic ureteral localization stent (PULSe) placed by urologists aids in intraoperative localization and detection of suspected ureteral injury during complex colorectal surgery (CRS) cases. We evaluated the incidence and management of urologic-induced complications secondary to PULSe placement during CRS cases at a single center. MATERIALS AND METHODS: We performed a retrospective review of all patients who underwent cystoscopy and PULSe placement at the time of CRS over a 12-month period...
December 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Cezary Kułak, Marcin Cierniak, Tomasz Gaszyński
UNLABELLED: An effective and dexterously established airway management of patients in life-threatening conditions is one of the basic procedures. Endotracheal intubation is considered to be the best method, however when, difficulties occur, it is indispensable to use of alternative methods with expertise. AIM: The aim of the research is to compare the effectiveness of endotracheal intubation management while using 5 different supragrottic airway devices with and without a flexible tracheal tube introducer...
September 2015: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
M Eikermann
General health checks are intended to identify risk factors or detect early signs of disease and to reduce mortality and morbidity from the disease by early interventions. Screening tests are not always beneficial; therefore, they have to be critically assessed with respect to the benefits and harms. Especially for general health checks there seems to be less awareness for potential harms than for other screening procedures because the diagnostic interventions are mostly less invasive and have low-risks of direct harms, such as ultrasonography or electrocardiography (ECG)...
October 2015: Der Internist
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