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https://www.readbyqxmd.com/read/29667157/devices-and-endoscopic-bariatric-therapies-for-obesity
#1
REVIEW
Katherine H Saunders, Leon I Igel, Monica Saumoy, Reem Z Sharaiha, Louis J Aronne
PURPOSE OF REVIEW: In this review, we describe the FDA-approved and investigational devices and endoscopic bariatric therapies for the treatment of obesity. We focus on literature published in the past few years and present mechanisms of action as well as efficacy and safety data. RECENT FINDINGS: Devices and endoscopic procedures are emerging options to fill the significant treatment gap in the management of obesity. Not only are these devices and procedures minimally invasive and reversible, but they are potentially more effective than antiobesity medications, often safer for poor surgical candidates and possibly less expensive than bariatric surgery...
April 17, 2018: Current Obesity Reports
https://www.readbyqxmd.com/read/29450849/impaired-arterial-responsiveness-in-untreated-gout-patients-compared-with-healthy-non-gout-controls-association-with-serum-urate-and-c-reactive-protein
#2
Svetlana Krasnokutsky, Aaron Garza Romero, Daisy Bang, Virginia C Pike, Binita Shah, Talia F Igel, Irina Dektiarev, Yu Guo, Judy Zhong, Stuart D Katz, Michael H Pillinger
To determine whether arterial responsiveness is impaired among patients with gout, and whether arterial responsiveness inversely correlates with serum urate and inflammatory measures. This is a cross-sectional study of untreated gout subjects (n = 34) and non-gout healthy controls (n = 64). High-resolution dynamic ultrasound-measured flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) assessed endothelium-dependent and endothelium-independent arterial responsiveness respectively. Serum urate (sUA) and high-sensitivity C-reactive protein (hsCRP) were measured in the gout group, and correlated with FMD and NMD responses...
February 15, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29405206/the-potential-of-3d-printing-in-urological-research-and-patient-care
#3
REVIEW
Marc Colaco, Daniel A Igel, Anthony Atala
3D printing is an evolving technology that enables the creation of unique organic and inorganic structures with high precision. In urology, the technology has demonstrated potential uses in both patient and clinician education as well as in clinical practice. The four major techniques used for 3D printing are inkjet printing, extrusion printing, laser sintering, and stereolithography. Each of these techniques can be applied to the production of models for education and surgical planning, prosthetic construction, and tissue bioengineering...
February 6, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29301257/prion-strains-and-transmission-barrier-phenomena
#4
REVIEW
Angélique Igel-Egalon, Vincent Béringue, Human Rezaei, Pierre Sibille
Several experimental evidences show that prions are non-conventional pathogens, which physical support consists only in proteins. This finding raised questions regarding the observed prion strain-to-strain variations and the species barrier that happened to be crossed with dramatic consequences on human health and veterinary policies during the last 3 decades. This review presents a focus on a few advances in the field of prion structure and prion strains characterization: from the historical approaches that allowed the concept of prion strains to emerge, to the last results demonstrating that a prion strain may in fact be a combination of a few quasi species with subtle biophysical specificities...
January 1, 2018: Pathogens
https://www.readbyqxmd.com/read/29156182/obesity-pharmacotherapy
#5
REVIEW
Katherine H Saunders, Devika Umashanker, Leon I Igel, Rekha B Kumar, Louis J Aronne
Although diet, physical activity, and behavioral modifications are the cornerstones of weight management, weight loss achieved by lifestyle modifications alone is often limited and difficult to maintain. Pharmacotherapy for obesity can be considered if patients have a body mass index (BMI) of 30 kg/m2 or greater or BMI of 27 kg/m2 or greater with weight-related comorbidities. The 6 most commonly used antiobesity medications are phentermine, orlistat, phentermine/topiramate extended release, lorcaserin, naltrexone sustained release (SR)/bupropion SR, and liraglutide 3...
January 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29127458/safety-pharmacokinetics-and-pharmacodynamics-of-single-rising-doses-of-bi-655064-an-antagonistic-anti-cd40-antibody-in-healthy-subjects-a-potential-novel-treatment-for-autoimmune-diseases
#6
Fredrik N Albach, Frank Wagner, Andreas Hüser, Julia Igel, David Joseph, James Hilbert, Corinna Schoelch, Steven J Padula, Jürgen Steffgen
PURPOSE: The CD40-CD40L pathway is a promising treatment target for autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and lupus nephritis. The safety, pharmacokinetics and pharmacodynamics of BI 655064, a novel humanised antagonistic anti-CD40 monoclonal antibody, were investigated in this first-in-human trial. METHODS: Healthy male subjects (n = 72) were randomised 3:1, within each BI 655064 dose group, to single intravenous (IV; 0...
February 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29080509/natural-cellulose-ionogels-for-soft-artificial-muscles
#7
Daria Nevstrueva, Kirill Murashko, Veiko Vunder, Alvo Aabloo, Arto Pihlajamäki, Mika Mänttäri, Juha Pyrhönen, Tuomas Koiranen, Janno Torop
Rapid development of soft micromanipulation techniques for human friendly electronics has raised the demand for the devices to be able to carry out mechanical work on a micro- and macroscale. The natural cellulose-based ionogels (CEL-iGEL) hold a great potential for soft artificial muscle application, due to its flexibility, low driving voltage and biocompatibility. The CEL-iGEL composites undergo reversible bending already at ±500mV step-voltage values. A fast response to the voltage applied and high ionic conductivity of membranous actuator is achieved by a complete dissolution of cellulose in 1-ethyl-3-methylimidazolium acetate [EMIm][OAc]...
October 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28991935/obesity-when-to-consider-medication
#8
REVIEW
Katherine H Saunders, Alpana P Shukla, Leon I Igel, Louis J Aronne
These 4 cases illustrate how weight loss drugs--including the 4 newest--can be integrated into a treatment plan that includes diet, exercise, and behavior modification.
October 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28973359/challenges-in-doing-multi-disciplinary-health-promotion-research-in-germany
#9
Ulrike Igel, Ruth Gausche, Martina Lück, Tobias Lipek, Ulrike Spielau, Maria Garz, Wieland Kiess, Gesine Grande
Health problems such as obesity are increasingly addressed by complex intervention programmes which operate at multiple levels of influence (e.g. families, schools, neighbourhoods) involving partners from various academic, professional and cultural backgrounds. Following a complex participatory health promotion approach is challenging, because conflicting interests as well as contextual constraints may occur which are rarely discussed empirically. Process evaluations of some programmes investigate factors influencing the implementation process...
August 23, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28947009/a-multi-variate-blind-source-separation-algorithm
#10
M Goldhacker, P Keck, A Igel, E W Lang, A M Tomé
BACKGROUND AND OBJECTIVE: The study follows the proposal of decomposing a given data matrix into a product of independent spatial and temporal component matrices. A multi-variate decomposition approach is presented, based on an approximate diagonalization of a set of matrices computed using a latent space representation. METHODS: The proposed methodology follows an algebraic approach, which is common to space, temporal or spatiotemporal blind source separation algorithms...
November 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28880932/reversible-unfolding-of-infectious-prion-assemblies-reveals-the-existence-of-an-oligomeric-elementary-brick
#11
Angélique Igel-Egalon, Mohammed Moudjou, Davy Martin, Alexandra Busley, Tina Knäpple, Laetitia Herzog, Fabienne Reine, Nad'a Lepejova, Charles-Adrien Richard, Vincent Béringue, Human Rezaei
Mammalian prions, the pathogens that cause transmissible spongiform encephalopathies, propagate by self-perpetuating the structural information stored in the abnormally folded, aggregated conformer (PrPSc) of the host-encoded prion protein (PrPC). To date, no structural model related to prion assembly organization satisfactorily describes how strain-specified structural information is encoded and by which mechanism this information is transferred to PrPC. To achieve progress on this issue, we correlated the PrPSc quaternary structural transition from three distinct prion strains during unfolding and refolding with their templating activity...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28649438/translational-learning-from-clinical-studies-predicts-drug-pharmacokinetics-across-patient-populations
#12
Markus Krauss, Ute Hofmann, Clemens Schafmayer, Svitlana Igel, Jan Schlender, Christian Mueller, Mario Brosch, Witigo von Schoenfels, Wiebke Erhart, Andreas Schuppert, Michael Block, Elke Schaeffeler, Gabriele Boehmer, Linus Goerlitz, Jan Hoecker, Joerg Lippert, Reinhold Kerb, Jochen Hampe, Lars Kuepfer, Matthias Schwab
Early indication of late-stage failure of novel candidate drugs could be facilitated by continuous integration, assessment, and transfer of knowledge acquired along pharmaceutical development programs. We here present a translational systems pharmacology workflow that combines drug cocktail probing in a specifically designed clinical study, physiologically based pharmacokinetic modeling, and Bayesian statistics to identify and transfer (patho-)physiological and drug-specific knowledge across distinct patient populations...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28646934/timing-interval-from-peri-prostatic-block-to-biopsy-impacts-procedural-pain
#13
Ram A Pathak, David D Thiel, Alexander Parker, Michael G Heckman, Julia E Crook, Nancy N Diehl, Andrea Tavlarides, Scott W Alford, Todd C Igel
INTRODUCTION: To compare visual analog scale (VAS) pain scores between patients with a 2-minute versus 10-minute delay of peri-prostatic lidocaine injection prior to transrectal ultrasound-guided prostate biopsies (TRUS-bx). MATERIALS AND METHODS: Eighty patients who underwent standard 12-core TRUS-bx by a single surgeon were prospectively randomized into four different treatment arms: bibasilar injection with a 2-minute delay, bibasilar injection plus a single apical injection with a 2-minute delay, bibasilar injection with a 10-minute delay, and bibasilar injection plus a single apical injection with a 10-minute delay...
June 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28486361/universal-cervical-length-screening-and-antenatal-corticosteroid-timing
#14
Nicole Sahasrabudhe, Catherine Igel, Ghislaine C Echevarria, Peʼer Dar, Diana Wolfe, Peter S Bernstein, Robert Angert, Ashlesha Dayal, Patience Gallagher, Mara Rosner
OBJECTIVE: To evaluate the relationship between universal transvaginal screening for short cervical length in the second trimester and the timing of antenatal corticosteroids. METHODS: We performed a retrospective cohort study of patients with nonanomalous singleton gestations and spontaneous preterm birth between 24 and 34 weeks of gestation after the initiation of a universal transvaginal cervical length screening program between October 2012 and August 2015. Our primary outcome was antenatal corticosteroid administration to a delivery interval of fewer than 7 days...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28419888/zika-sexual-transmission-and-prudent-public-health-policy
#15
K M Folkers, A L Caplan, L H Igel
No abstract text is available yet for this article.
July 2017: Public Health
https://www.readbyqxmd.com/read/28371396/use-of-lorcaserin-for-glycemic-control-in-patients-with-type-2-diabetes-mellitus
#16
Leon I Igel, Louis J Aronne
No abstract text is available yet for this article.
May 2017: Obesity
https://www.readbyqxmd.com/read/28357052/recent-advances-in-understanding-and-managing-gout
#17
REVIEW
Talia F Igel, Svetlana Krasnokutsky, Michael H Pillinger
Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Unfortunately, gout remains under-diagnosed and under-treated in the general community. Despite major advances in treatment strategies, as many as 90% of patients with gout are poorly controlled or improperly managed and their hyperuricemia and recurrent flares continue...
2017: F1000Research
https://www.readbyqxmd.com/read/28292399/current-and-future-medical-treatment-of-obesity
#18
REVIEW
Devika Umashanker, Leon I Igel, Rekha B Kumar, Louis J Aronne
Obesity is a major health crisis resulting in comorbidities such as hypertension, type 2 diabetes, and obstructive sleep apnea. The need for safe and efficacious drugs to help assist with weight loss and reduce cardiometabolic risk factors is great. With several FDA-approved drugs on the market, there is still a great need to develop long-term obesity treatments or noninvasive oral agents to help assist individuals with obesity when used in conjunction with lifestyle modifications.
April 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28281924/a-stretch-of-residues-within-the-protease-resistant-core-is-not-necessary-for-prion-structure-and-infectivity
#19
Carola Munoz-Montesino, Christina Sizun, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Angelique Igel-Egalon, Clément Barbereau, Jérôme Chapuis, Danica Ciric, Hubert Laude, Vincent Béringue, Human Rezaei, Michel Dron
Mapping out regions of PrP influencing prion conversion remains a challenging issue complicated by the lack of prion structure. The portion of PrP associated with infectivity contains the α-helical domain of the correctly folded protein and turns into a β-sheet-rich insoluble core in prions. Deletions performed so far inside this segment essentially prevented the conversion. Recently we found that deletion of the last C-terminal residues of the helix H2 was fully compatible with prion conversion in the RK13-ovPrP cell culture model, using 3 different infecting strains...
January 2, 2017: Prion
https://www.readbyqxmd.com/read/28192104/practical-use-of-pharmacotherapy-for-obesity
#20
REVIEW
Leon I Igel, Rekha B Kumar, Katherine H Saunders, Louis J Aronne
Obesity management requires a multidisciplinary approach, as there are many factors that contribute to the development of obesity, as well as the preservation of excess weight once it has been gained. Diet, exercise, and behavior modification are key components of treatment. In addition to lifestyle changes, weight gain secondary to medications is an important modifiable risk factor. Even after appropriate lifestyle modification, and medication adjustments (where possible) to avoid agents that can contribute to weight gain, many patients are still unable to achieve clinically meaningful weight loss...
May 2017: Gastroenterology
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