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https://www.readbyqxmd.com/read/28821573/dynamic-risk-stratification-in-the-follow-up-of-thyroid-cancer
#1
Jolanta Krajewska, Ewa Chmielik, Barbara Jarzab
The adequate risk stratification in thyroid carcinoma, is crucial to avoid on one hand the overtreatment of low-risk and on the other hand the undertreatment of high-risk patients. The question how to properly assess the risk of relapse has been discussed during recent years and resulted in a substantial change in our approach to risk stratification in differentiated thyroid cancer, proposed by the newest ATA guidelines. First initial risk stratification, based on histopathological data is carried out just after primary surgery...
August 18, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28814219/coeliac-disease-review-of-diagnosis-and-management
#2
Marjorie M Walker, Jonas F Ludvigsson, David S Sanders
Coeliac disease is an immune-mediated systemic disease triggered by exposure to gluten, and manifested by small intestinal enteropathy and gastrointestinal and extra-intestinal symptoms. Recent guidelines recommend a concerted use of clear definitions of the disease. In Australia, the most recent estimated prevalence is 1.2% in adult men (1:86) and 1.9% in adult women (1:52). Active case finding is appropriate to diagnose coeliac disease in high risk groups. Diagnosis of coeliac disease is important to prevent nutritional deficiency and long term risk of gastrointestinal malignancy...
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28795453/validation-of-the-modified-4-tiered-categorization-system-through-comparison-with-the-5-tiered-categorization-system-of-the-2015-american-thyroid-association-guidelines-for-classifying-small-thyroid-nodules-on-ultrasound
#3
Ji Hye Lee, Kyunghwa Han, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y Park, Jin Young Kwak
BACKGROUND: The purpose of this study was to validate the modified 4-tiered categorization system and to compare stratification of malignancy risk in small thyroid nodules with the 2015 American Thyroid Association (ATA) management guidelines. METHODS: From January 2015 to December 2015, 737 thyroid nodules measured ≥ 1 cm and <2 cm were included in this study. Each nodule was assigned a category with the ultrasonographic patterns described by the 2015 ATA guidelines...
August 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28782127/crucial-parameters-in-thyroid-carcinoma-reporting-challenges-controversies-and-clinical-implications
#4
Bin Xu, Ronald Ghossein
In the modern era, a pathology report of thyroid carcinoma requires the inclusion of numerous prognostically relevant histopathologic features, e.g. the presence and extent of vascular and capsular invasion, extrathyroidal extension, the surgical margin status, and the characteristics of nodal metastasis. These pathologic features are crucial components of the initial risk stratification to determine the need for completion thyroidectomy and/or post-operative radioactive iodine ablation therapy. The current review aims to summarize the diagnostic criteria, the controversies, the prognostic impacts, and the challenges of these pathologic characteristics, focusing specifically on the parameters that are incorporated into the American Joint Committee on Cancer (AJCC) staging system, College of American Pathologists (CAP) reporting template, American Thyroid Association (ATA), and National Comprehensive Cancer Network (NCCN) guidelines...
August 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28748505/comparison-of-consecutive-results-from-fine-needle-aspiration-and-core-needle-biopsy-in-thyroid-nodules
#5
Soon-Hyun Ahn, So-Yeon Park, Sang Il Choi
There are papers suggesting the complementary role of core needle biopsy (CNB) in the diagnosis of thyroid nodules. By comparing the result of CNB and fine needle aspiration (FNA) cytology performed in consecutive cases of thyroid nodules, the role of CNB was evaluated. Retrospective reviews of 2131 FNA and 275 CNB which were performed as first-line biopsy for 2406 thyroid nodules in 2187 patients were performed. The ultrasound (US) feature of thyroid nodule was classified following the risk of malignancy suggested by American Thyroid Association (ATA) guideline...
July 26, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28746798/thyroid-disease-symptoms-during-early-pregnancy-do-not-identify-women-with-thyroid-hypofunction-that-should-be-treated
#6
V J Pop, M A Broeren, W M Wiersinga, A Stagnaro-Green
OBJECTIVE: to evaluate whether women during early pregnancy with ''hypothyroidism'' symptoms are at risk for biochemical defined hypothyroidism. The 2017 guidelines of the American Thyroid Association (ATA) recommend case finding on the basis of symptoms to identify these women during pregnancy, while evidence is lacking. DESIGN: Construct validation of a thyroid hypofunction symptom checklist during first trimester of pregnancy comparing high scores with biochemical defined hypothyroidism...
July 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28729773/is-new-american-thyroid-association-risk-classification-for-hereditary-medullary-thyroid-carcinoma-applicable-to-chinese-patients-a-single-center-study
#7
Xiwei Zhang, Dangui Yan, Junyi Wang, Hanfeng Wan, Yongxia Zhang, Yabing Zhang, Yuqin He, Wensheng Liu, Bin Zhang
OBJECTIVE: The American Thyroid Association (ATA) proposed a new risk classification for hereditary medullary thyroid carcinoma (MTC) in 2015. This study aimed to assess whether the new guidelines are suitable for the Chinese population, and reported our experience on prophylactic thyroidectomy. METHODS: A total of 73 patients from 22 families were screened as rearranged during transfection (RET) mutation carriers from 2010 to 2016 in Cancer Hospital, Chinese Academy of Medical Science; the medical history for each patient was collected...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28723762/recombinant-human-tsh-stimulated-thyroglobulin-levels-at-remnant-ablation-predict-structural-incomplete-response-to-treatment-in-patients-with-differentiated-thyroid-cancer
#8
Jeonghoon Ha, Min Hee Kim, Kwanhoon Jo, Yejee Lim, Ja Seong Bae, Sohee Lee, Moo Il Kang, Bong Yun Cha, Dong Jun Lim
In patients with differentiated thyroid cancer, stimulated thyroglobulin (sTg) levels after thyroid hormone withdrawal (THW) at remnant ablation (RA) and at 6 to 12 months are known to have good prognostic value. This study aimed to evaluate the prognostic impacts and best cutoff values of sTg levels under recombinant human thyroid stimulating hormone (rhTSH) treatment at RA and at follow-up. A total of 151 patients were enrolled, of whom 77 were followed up with rhTSH-stimulated Tg (rhTSH-sTg) and 74 with THW-stimulated Tg (THW-sTg) at 6 to 12 months after rhTSH-aided RA...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28719972/risk-stratification-of-thyroid-nodules-with-atypia-of-undetermined-significance-follicular-lesion-of-undetermined-significance-aus-flus-cytology-using-ultrasonography-patterns-defined-by-the-2015-ata-guidelines
#9
Ji Hye Lee, Kyunghwa Han, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y Park, Jin Young Kwak
PURPOSE: The purpose of this study was to evaluate the predictive value of ultrasonography (US) patterns based on the 2015 American Thyroid Association (ATA) guidelines for malignancy in atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) nodules. METHODS: From January 2014 to August 2015, 133 thyroid nodules that were initially diagnosed as AUS/FLUS on fine needle aspiration (FNA) were included in this study. Each nodule was assigned a category with US patterns defined by the ATA guidelines...
September 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28699414/role-of-ultrasound-in-predicting-tumor-invasiveness-in-follicular-variant-of-papillary-thyroid-carcinoma
#10
Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Tae Hyuk Kim, Yaeji Lim, Ji Soo Choi
BACKGROUND: Follicular variant of papillary thyroid carcinoma (FVPTC) is traditionally divided into infiltrative and encapsulated types. Adding to this classification, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a reclassification of a subset of cases (encapsulated tumors without lymphovascular or capsular invasion). The purpose of this study was to assess the role of ultrasound (US) in predicting tumor invasiveness in FVPTC. METHODS: From January 2014 to May 2016, preoperative US examinations were performed on 151 patients with 152 FVPTCs who underwent surgery...
August 7, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28690859/case-report-of-a-lupus-patient-with-a-severe-flare-and-miliary-tuberculosis-need-for-proper-guidelines-for-management
#11
Masooma Hashmat, Ramsa Suhail Rana, Tafazzul-E-Haque Mahmud, Aflak Rasheed, Ata Ur Rehman, Syed Ali Rukh Pirzada, Muhammad Ammad Asghar, Sadia Asif, Amjad Ali
Systemic lupus erythematosus (SLE) is an autoimmune disease that is frequently treated with high doses of corticosteroids and other immunosuppressive drugs. Thus patients with SLE are at increased risk for infections with several pathogens including Mycobacterium tuberculosis. There are no established guidelines available for treatment of tuberculosis in SLE patients with high disease activity due to lack of relevant studies and management based more on physician expertise. We report a case of a young SLE patient with high disease activity index (SLEDAI19) as evidenced by the presence of a vasculitic rash, non-healing ulcer on forearm and proteinuria of >1 g/d along with miliary tuberculosis...
July 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28689321/underestimated-risk-of-cancer-in-solitary-thyroid-nodules-%C3%A2-3%C3%A2-cm-reported-as-benign
#12
Sohail Bakkar, Anello Marcello Poma, Caterina Corsini, Mario Miccoli, Carlo Enrico Ambrosini, Paolo Miccoli
BACKGROUND: The study aims to assess the risk of cancer in solitary thyroid nodules ≥30 mm in size reported as Bethesda II, and its implications. METHOD: The clinical records of 202 patients, who underwent thyroid lobectomy for solitary nodules measuring ≥30 mm, reported as Bethesda II on preoperative FNAC between Jan 2015 and Apr 2016 were reviewed. Data collected included nodule size and consistency, and final histopathology results. The risk of cancer and the recommended management according to ATA guidelines were the outcomes of interest...
July 8, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28609830/medullary-thyroid-carcinoma-in-men2a-ata-moderate-or-high-risk-ret-mutations-do-not-predict-disease-aggressiveness
#13
Rachel K Voss, Lei Feng, Jeffrey E Lee, Nancy D Perrier, Paul H Graham, Samuel M Hyde, Frances Nieves-Munoz, Maria E Cabanillas, Steven G Waguespack, Gilbert J Cote, Robert F Gagel, Elizabeth G Grubbs
Context: High-risk RET mutations (codon 634) are associated with earlier development of medullary thyroid carcinoma (MTC) and presumed increased aggressiveness compared with moderate-risk RET mutations. Objective: To determine whether high-risk RET mutations are more aggressive. Design: Retrospective cohort study using institutional multiple endocrine neoplasia type 2 registry. Setting: Tertiary cancer care center. Patients: Patients with MTC and moderate- or high-risk germline RET mutation...
August 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28593402/clinical-presentation-and-prognostic-indicators-in-100-adults-and-children-with-neurofibromatosis-1-associated-non-optic-pathway-brain-gliomas
#14
Susan Byrne, Steve Connor, Karine Lascelles, Ata Siddiqui, Darren Hargrave, Rosalie E Ferner
Type 1 Neurofibromatosis (NF1) is a common autosomal dominant condition, with a major impact on the nervous system, eye, bone, and skin, and a predisposition to malignancy. At present it is not possible to predict clinically or on imaging, whether a brain tumour will remain indolent or undergo high-grade change. There are no consensus guidelines on the follow-up of non-optic pathway glioma (non-OPG) tumours in NF1. One hundred patients from the National NF1 Service with generalised NF1 and a diagnosis of non-OPG glioma were followed up for a median time of 63 months after glioma detection...
July 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28572820/tsh-variability-of-patients-affected-by-differentiated-thyroid-cancer-treated-with-levothyroxine-liquid-solution-or-tablet-form
#15
Carlo Cappelli, Ilenia Pirola, Elena Gandossi, Claudio Casella, Davide Lombardi, Barbara Agosti, Fiorella Marini, Andrea Delbarba, Maurizio Castellano
BACKGROUND: Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L. The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with liquid L-T4 formulation or in tablet form. PATIENTS AND METHODS: Patients were eligible if (a) they were submitted to a total thyroidectomy and (131)I remnant ablation for DTC in our institution and (b) they were classified low-risk patients according to ATA guidelines 2009...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28567504/a%C3%A2-clinical-example-of-extreme-dose-exposure-for-an-implanted-cardioverter-defibrillator-beyond-the-degro-guidelines
#16
Yoana Hristova, Janett Köhn, Stefanie Preuß, Claus Rödel, Panagiotis Balermpas
INTRODUCTION: Considering that the number of malignant diseases in patients over 65 years of age is increasing, it often occurs that patients who carry a cardiac implanted electronic device must undergo radiotherapy. Ionizing radiation can disturb the function of the implantable cardioverter-defibrillator (ICD). As a result of this, an update of the DEGRO/DKG guidelines for radiotherapy of this patient group has been published. METHODS: We report the case of a patient with an ICD and T‑lymphoblastic lymphoma with cardiac involvement, who received i...
May 31, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28560738/evaluation-of-ultrasound-reporting-for-thyroid-cancer-diagnosis-and-surveillance
#17
Meghan E Rowe, Marcela Osorio, Ilya Likhterov, Mark L Urken
BACKGROUND: Despite the importance of ultrasound imaging in thyroid disease care, ultrasound reports vary greatly in the features described. It is essential that ultrasound reports contain and present all components necessary for a clinical decision in a reader-friendly format. METHODS: One hundred ninety thyroid and neck ultrasound reports were scored using the universal ultrasound report template developed by Su et al, along with the American Thyroid Association (ATA) and the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi/European Thyroid Association (AACE/AME/ETA) guidelines...
May 31, 2017: Head & Neck
https://www.readbyqxmd.com/read/28554990/the-role-of-scube1-in-the-pathogenesis-of-no-reflow-phenomenon-presenting-with-st-segment-elevation-myocardial-infarction
#18
Hasan Ata Bolayır, Hakan Güneş, Tarık Kıvrak, Ömer Şahin, Dursun Akaslan, Recep Kurt, Aslı Bolayır, Oya İmadoğlu
OBJECTIVE: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] might function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Acute myocardial infarction is one of the most common causes of death in modern society. The concept of "no reflow" (NR) refers to a state of myocardial tissue hypoperfusion in the presence of a patent epicardial coronary artery. The main mechanisms of this phenomenon are thought to be high platelet activity and much thrombus burden...
May 24, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28545338/radiofrequency-ablation-of-small-follicular-neoplasms-initial-clinical-outcomes
#19
Su Min Ha, Jin Yong Sung, Jung Hwan Baek, Dong Gyu Na, Ji-Hoon Kim, Hyunju Yoo, Ducky Lee, Dong Whan Choi
BACKGROUND: In thyroid gland, radiofrequency ablation (RFA) has been applied to both recurrent cancers and benign nodules, although, according to the American Thyroid Association (ATA) and the Korean Society of Thyroid Radiology (KSThR) guidelines, surgery is the first-line treatment for follicular neoplasm. However, it has been argued that follicular neoplasm with lower risk of malignancy can be managed by close follow-up. In this study, we evaluated the effectiveness of RFA of small follicular neoplasms, examining reductions in volume and related clinical problems, and making observations over long-term follow-up...
May 25, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28506409/the-surgical-approach-to-nodule-thyr-3-4-after-the-2-2014-nccn-and-2015-ata-guidelines
#20
Paolo Del Rio, Paola Pisani, Chiara Montana Montana, Simona Cataldo, Michela Marina, Graziano Ceresini
BACKGROUND: The incidence of palpables thyroid nodules in general population is 5% and the prevalence of non -palpable nodules is higher (35-60%) in the endemic goiter area. In the last years the new guidelines and new classification related to thyroid nodule have changed the indication to treat it. MATERIAL AND METHOD: We analyzed the patients treated from January 2013 to June 2016 for Thyr 3 and Thyr 4 thyroid nodule sec. Bethesda system. We have divided in I and II period related to the 2...
May 2017: International Journal of Surgery
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