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Jianguo Wei, Aijing Sun, Jian Tao, Cheng Wang, Fang Liu
Primary adrenal leiomyosarcoma is a very rare tumor with an unusual location; the diagnosis is based entirely on histological and immunohistochemical evaluations. We report a primary adrenal leiomyosarcoma in a 57-year-old woman who was incidentally found to have an adrenal-occupying lesion during a routine medical examination. Computed tomography revealed a 64 mm × 77 mm soft tissue mass in the left adrenal gland. The patient underwent left radical nephroadrenalectomy. Histological examination of the tumor showed malignant spindle cells in interlacing fasicles and whorls...
December 2014: International Journal of Surgical Pathology
Eijiro Maeda, Shangjun Ye, Wen Wang, Dan L Bader, Martin M Knight, David A Lee
Gap junction communication is an essential component in the mechanosensitive response of tenocytes. However, little is known about direct mechanoregulation of gap junction turnover and permeability. The present study tests the hypothesis that mechanical loading alters gap junction communication between tenocyte within tendon fascicles. Viable tenocytes within rat tail tendon fasicles were labelled with calcein-AM and subjected to a fluorescent loss induced by photobleaching (FLIP) protocol. A designated target cell within a row of tenocytes was continuously photobleached at 100% laser power whilst recording the fluorescent intensity of neighbouring cells...
March 2012: Biomechanics and Modeling in Mechanobiology
Helle Rasmussen, Alastair Hansen, Frank Smedts, Jüri J Rumessen, Thomas Horn
Interstitial cells of Cajal (ICC) are well described in the bowel wall. They are c-kit positive and play a role as pacemaker cells. Similar c-kit-positive cells have recently been described in the human bladder. The aim of this study was to characterize interstitial cells of the bladder detrusor using a panel of antibodies directed against CD117/c-kit, CD34, CD31, S100, tryptase, neurofilament, NSE, Factor-VIII and GFAP. A striking finding was an interstitial type of cell which is CD34 immunoreactive (CD34-ir) but CD117/c-kit negative...
November 2007: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Joanne Garvin, Jie Qi, Melissa Maloney, Albert J Banes
Cells cultured in three-dimensional collagen gels express a more native state phenotype because they form a syncytial network that can be mechanically loaded. Moreover, cells remodel their matrix by eliminating water, and by reorganizing and aligning the collagen fibrils. Last, the ability to subject cells to mechanical loading in a native matrix is desirable because cells, in tissues as well as the matrix, bear strains and alter their expression profile consistent with either immobilization, moderate activity, or repetitive loading...
October 2003: Tissue Engineering
Francie E Coblentz, Monte J Radeke, Geoffrey P Lewis, Steven K Fisher
Growth associated protein 43 (GAP 43) is involved in synapse formation and it is expressed in the retina in a very specific pattern. Although GAP 43 is downregulated at the time of synapse formation, it can be re-expressed following injury such as axotomy or ischemia. Because of this we sought to characterize the expression of GAP 43 after retinal detachment (RD). Immunoblot, immunocytochemical and quantitative polymerase chain reaction (QPCR) techniques were used to assess the level of GAP 43 expression after experimental RD...
March 2003: Experimental Eye Research
Yingyong Hou, Jian Wang, Xiongzeng Zhu, Xiang Du, Menghong Sun, Aihua Zheng
OBJECTIVE: To study the morphologic and immunohistochemical features of gastrointestinal stromal tumors (GISTs) and to explore the reference parameters for malignancy. METHODS: Seventy six (76) cases of primary GISTs were distinguished from a group of gastrointestinal mesenchymal tumors by use of a panel of antibodies such as CD117, CD34 by immunohistochemical EnVision method, their biologic behaviors were analyzed by including their follow-up data. RESULTS: All patients were adults, age range 32 to 81 years (mean 54 year), male 39 cases and female 37 cases; the tumors were situated in stomach (36 cases), in small intestine (23 cases), colon (2 cases) and rectum (15 cases)...
February 2002: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
N A Ebraheim, J Lu, H Yang, M Huntoon, R A Yeasting
Two hundred and forty histological paraffin sections were obtained from the midportion of the spinal nerve roots of 20 lumbosacral plexus (from L4 to S3) bilaterally. All microscopic images were digitized using the NIH image software with a Nikon microscope and Sony videocamera. The total, fascicular as well as epineurial cross-sectional areas of the nerve roots in the lumbosacral plexus were determined. The total cross-sectional area of the lumbosacral trunk (LST) was the largest (28.56 +/- 12.28 mm2) followed by the S1 (21...
1997: Acta Anatomica
J M Spencer, R A Amonette
BACKGROUND: In the classification of tumors of soft tissue, modern schemes describe tumors by the normal adult tissue type the tumor resembles. Thus, tumors are described as smooth muscle tumors if the cells are differentiating towards smooth muscle. We may infer that in fact the tumor arose from smooth muscle, but this is only an inference. Tumors showing differentiation towards smooth muscle include hamartomas, benign tumors, and malignant tumors. OBJECTIVE: This review article describes the clinical presentation and course, histology, and treatment recommendations for benign and malignant smooth muscle tumors...
September 1996: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
R N Ranson, P J Butler, E W Taylor
The location of vagal preganglionic neurones (VPN) has been determined in nine ferrets (Mustela putorius furo) and seven mink (M. vison) using neuronal tract-tracing techniques employing horseradish peroxidase (HRP) and wheat-germ agglutinin conjugated HRP (WGA-HRP) mixtures injected into the nodose ganglion of the vagus nerve. Labelled VPN were located ipsilaterally in the dorsal motor nucleus of the vagus (DmnX), nucleus ambiguus (nA), and reticular formation (rf) of the medulla oblongata. In four of the ferrets, labelled VPN were also identified in the nucleus dorsomedialis (ndm) and the nucleus of the spinal accessory nerve (nspa)...
May 1993: Journal of the Autonomic Nervous System
B G Wallin, L Stjernberg
Microelectrode recordings were made in peroneal skin nerve fasicles in 8 patients with functionally complete spinal cord lesions mainly at cervical levels. Spontaneous neural activity was sparse but deep breaths, abdominal pressure over the bladder and mechanical and electrical skin stimuli applied caudal to the spinal transection induced bursts of neural impulses after a latency of 0.5 to 1 s. The efferent discharges were conducted with a velocity of 0.75 m/s and were followed by cutaneous vasoconstruction and/or reduction of skin resistance...
March 1984: Brain: a Journal of Neurology
M R Bennett, T Florin, R Woog
1. A histological and electrophysiological study has been made of the formation of synapses in soleus and extensor digitorum longus muscles of adult rats regenerating from minced muscle fragments.2. In the first 8 days of regeneration, myoblast and myotubes formed within the basement membranes of degenerating myofibres.3. Eleven- to fourteen-day regenerates contained fasicles of myotubes and myofibres and both nerves and spontaneous miniature end-plate potentials (m.e.p.p.s) were observed for the first time, although very few synapses show evoked end-plate potentials (e...
April 1974: Journal of Physiology
L S Green, R L Lux, C W Haws, R R Williams, S C Hunt, M J Burgess
Body surface potential maps provide more detailed regional cardiac electrophysiologic information than the standard electrocardiogram. We performed a large-scale study of a normal population to form a comparison base for evaluation of the clinical utility of this technique. We analyzed body surface maps from 1113 normal subjects from 10 to 80 years old to detail map features as a function of age, sex, and body habitus. Maps were analyzed by visual inspection and by a spatial and temporal data reduction technique that allows statistical comparison of map features...
February 1985: Circulation
M McEntee, B A Summers, A de Lahunta, J Cummings
A 3-year-old horse presented with intermittent generalized seizures of 2-month duration. During interictal periods, the horse appeared normal and a cause for the seizures could not be identified. Necropsy revealed opacity of the leptomeninges, covering most of one cerebral hemisphere along with thinning and collapse of the cortex in the ipsilateral pyriform lobe. Histopathology demonstrated leptomeningeal vascular proliferation and meningothelial hyperplasia. Prominent tortuous vessels of the gyri and sulci extended into some regions of the subjacent cortex, where there was neuronal loss, ectopia, and disorganization...
1987: Acta Neuropathologica
L L Tres, A L Kierszenbaum
The nuclear organization of a particular step of cricket late spermiogenesis was examined by an electron microscope study of spermatids dispersed by air-liquid surface tension. Cell spreading techniques facilitate a display of condensing spermatid nuclei sufficient to allow interpretation of chromatin packaging processes. Results indicate that nuclei of late developing cricket spermatids are integrated by multiple packaging units as the result of an orderly aggregation of individual chromatin fibers. Each packaging unit consists of a thick fasicle, formed by the alignment of smooth chromatin fibers, which frays out into tassels of looped fibers...
September 1976: American Journal of Anatomy
A W English
Dissections, manipulation of ligamentary preparations, analysis of limb proportions, and quantitative aspects of forelimb myology are used to correlate forelimb morphology in fur seals and sea lions (sub-family Otariinae) with previously published data as to their locomotor function (English, '76a). Comparisons to structure and function in generalized fissiped carnivores are then used to elucidate locomotor adaptations in fur seals and sea lions. Unique features of forelimb function during swimming in these pinnipeds include the amounts of abduction-adduction and rotary movements used...
March 1977: Journal of Morphology
G von Bernuth, D Lang, R Hofstetter
The His bundle electrography has confirmed many earlier hypotheses about the localization of atrioventricular block and the mechanism of tachyarrythmias; beyond this, it has added new information. In this paper, normal values and results of the method during childhood are reviewed. The indication for His bundle electrography as an invasive method is limited in children. An important indication consists of clarification of unclear partial atrioventricular block and of the state of the remaining third fasicle in postoperative bifascicular block...
April 1978: Herz
S Johnson, M Rundell, W Platt
A case of leiomyosarcoma of the scrotum is presented. The tumor measured 3 X 2.5 X 2 cm and had been present as a slowly enlarging mass in the right scrotum for three months prior to excision. Light microscopy demonstrated the typical interlacing fasicles of neoplastic cells with eccentric cigar-shaped nuclei and electron microscopy confirmed the neoplastic cells to be of smooth muscle origin. A review of the world's literature revealed this to be the fifth reported case of leimyosarcoma confined to the scrotal wall...
May 1978: Cancer
E López
Denervated frog's semitendinosus muscles were studied. Fibrillation potentials generate propagated spikes which are conducted at a rate similar to that calculated for innervated muscles. The twitch tension per unit area was similar in denervated and innervated single fibres; the average value corresponded with values reported in the literature for fibres stimulated at 125/sec. Manganese ions (1-3 mM), selectively inhibit fibrillation potentials and have no appreciable effect upon evoked spikes. Mn2+ also inhibits (40-50%) the twitch responses and abolishes the resting tension of muscle fibres...
1979: Japanese Journal of Physiology
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