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Periprosthetic infection

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https://www.readbyqxmd.com/read/29778657/efficacy-of-antifungal-impregnated-cement-spacer-against-chronic-fungal-periprosthetic-joint-infections-after-total-knee-arthroplasty
#1
Jong-Keun Kim, Do-Yoon Lee, Dong-Wan Kang, Du-Hyun Ro, Myung Chul Lee, Hyuk-Soo Han
BACKGROUND: Although two-stage exchange arthroplasty is considered a treatment of choice for chronic features of fungal PJI (periprosthetic joint infection), there is no consensus for local use of antifungal agent. The purpose of this study was to evaluate the efficacy of antifungal-impregnated cement spacer (AICS). METHODS: Nine patients who were diagnosed and treated for chronic fungal PJI after TKA in a single center from January 2001 to December 2016 were enrolled...
May 16, 2018: Knee
https://www.readbyqxmd.com/read/29776853/outcomes-of-a-fixed-bearing-medial-cemented-unicondylar-knee-arthroplasty-design-survival-analysis-and-functional-score-of-460-cases
#2
Philip Winnock de Grave, Justine Barbier, Thomas Luyckx, Alexander Ryckaert, Paul Gunst, Luc Van den Daelen
BACKGROUND: Unicompartmental knee arthroplasty (UKA) is an alternative to total knee arthroplasty in isolated medial osteoarthritis (OA). However, despite satisfactory reports on the clinical performance, UKA revision rates are still concerning. This retrospective study reports on the long-term survivorship, functional outcomes, and reasons for revision in fixed-bearing UKA implant. METHODS: Between 2005 and 2013, 460 consecutive patients were treated with medial UKA in one center using a fixed-bearing UKA system...
April 24, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29775976/-are-there-any-differences-in-quality-or-complication-rate-in-total-knee-arthroplasty-after-establishing-a-centre-for-endoprosthesis
#3
Muzaffer Düzgünoglu, Wolfgang Hönle, Alexander Scheller, Alexander Schuh
BACKGROUND: The aim of the study is to show whether there are any changes in quality or incidence of complications in total knee arthroplasty (TKA) after establishing a centre for endoprothesis (EPZ). MATERIAL AND METHODS: We conducted a retrospective study comparing 100 TKAs one year before establishing an EPZ (Group I) with 100 TKAs one year after establishing an EPZ (group II). Data were collected by analysing our electronic documentation system, and the report of the rehabilitation hospital...
May 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29759856/malnutrition-and-the-development-of-periprosthetic-joint-infection-in-patients-undergoing-primary-elective-total-joint-arthroplasty
#4
Kier Blevins, Arash Aalirezaie, Noam Shohat, Javad Parvizi
BACKGROUND: Although an abundance of literature exists linking malnutrition with infectious complications in surgical patients, there is little specifically examining the link between malnutrition and periprosthetic joint infection (PJI). This study evaluated the relationship between abnormal nutritional parameters and development of PJI in patients undergoing primary total joint arthroplasty (TJA). METHODS: We retrospectively reviewed TJA patients from 2000 to 2016 with preoperative nutritional screening at a single institution...
April 23, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29756496/bilateral-total-hip-arthroplasty-one-stage-versus-two-stage-procedure
#5
Afshin Taheriazam, Gholamreza Mohseni, Ali A Esmailiejah, Farshad Safdari, Hashem Abrishamkarzadeh
BACKGROUND: Despite several studies, controversy has prevailed over the rate of complications following 1-stage and 2-stage bilateral total hip arthroplasty (THA). In the current study, we compare the complications and functional outcomes of 1-stage and 2-stage procedures. METHODS: One hundred and eighty patients (ASA class I or II) with bilateral hip osteoarthritis were assigned randomly to two equal groups. The two groups were matched in terms of age and sex. All of the surgeries were performed via the Hardinge approach using uncemented implants...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29752591/econazole-releasing-porous-space-maintainers-for-fungal-periprosthetic-joint-infection
#6
Alexander M Tatara, Allison J Rozich, Panayiotis D Kontoyiannis, Emma Watson, Nathaniel D Albert, George N Bennett, Antonios G Mikos
While antibiotic-eluting polymethylmethacrylate space maintainers have shown efficacy in the treatment of bacterial periprosthetic joint infection and osteomyelitis, antifungal-eluting space maintainers are associated with greater limitations for treatment of fungal musculoskeletal infections including limited elution concentration and duration. In this study, we have designed a porous econazole-eluting space maintainer capable of greater inhibition of fungal growth than traditional solid space maintainers...
May 11, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29752029/centrifugation-may-change-the-results-of-leukocyte-esterase-strip-testing-in-the-diagnosis-of-periprosthetic-joint-infection
#7
Rui Li, Qiang Lu, Yong-Gang Zhou, Wei Chai, Shi-Bi Lu, Ji-Ying Chen
BACKGROUND: Centrifugation is used to remove the color interference by erythrocytes in blood-synovial fluid samples before leukocyte esterase (LE) strip testing. However, the impact of centrifugation requires further study. METHODS: From April 2016 to October 2017, 133 (53 infected and 80 noninfected) patients were included in this study. One drop of synovial fluid was applied to LE strips before and after centrifugation in 110 cases. The other 23 cases could not be read without centrifugation due to the color disturbance caused by blood contamination...
April 19, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29746950/candida-periprosthetic-joint-infection-a-rare-and-difficult-to-treat-infection
#8
Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Jaime Lora-Tamayo, Laura Morata, Oscar Murillo, Helem Vilchez, Luisa Sorli, Laura Guío Carrión, José Mª Barbero, Julián Palomino-Nicás, Alberto Bahamonde, Alfredo Jover-Sáenz, Natividad Benito, Rosa Escudero, Marta Fernandez- Sampedro, Rafael Pérez Vidal, Lucía Gómez, Pablo S Corona, Benito Almirante, Javier Ariza, Carles Pigrau
BACKGROUND: Candida periprosthetic joint infection (CPJI) is a rare, difficult-to-treat disease. The purpose of this study was to evaluate the clinical characteristics and outcomes of CPJI treated with various surgical and antifungal strategies. METHODS: We conducted a multicenter retrospective study of all CPJI diagnosed between 2003 and 2015 in 16 Spanish hospitals. RESULTS: Forty-three patients included: median age, 75 years, and median Charlson Comorbidity Index score, 4...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746626/cutibacterium-avidum-colonization-in-the-groin-is-associated-with-obesity-a-potential-risk-factor-for-hip-periprosthetic-joint-infection-pji
#9
Laura Böni, Stefan P Kuster, Bianka Bartik, Reinhard Zbinden, Patrick O Zingg, Yvonne Achermann
Background: An increase in the incidence of hip periprosthetic joint infections (PJIs) caused by Cutibacterium avidum has recently been detected after implantation of hip arthroplasties with an anterior surgical approach. We raised the question of whether skin colonization with C. avidum differs between the anterior and the lateral thigh as areas of surgical incision fields. Methods: Between February and June 2017, we analyzed skin scrapings from the groin and the anterior and lateral thigh in all patients undergoing a primary hip arthroplasty...
May 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29745132/monitoring-metabolic-reactions-in-staphylococcus-epidermidis-exposed-to-silicon-nitride-using-in-situ-time-lapse-raman-spectroscopy
#10
Francesco Boschetto, Tetsuya Adachi, Satoshi Horiguchi, Danny Fainozzi, Fulvio Parmigiani, Elia Marin, Wenliang Zhu, Bryan McEntire, Toshiro Yamamoto, Narisato Kanamura, Osam Mazda, Eriko Ohgitani, Giuseppe Pezzotti
Staphylococcus epidermidis (S. epidermidis) is one of the leading nosocomial pathogens, particularly associated with periprosthetic infections of biomedical implants. Silicon nitride (Si3N4), a nonoxide biomaterial widely used in spinal implants, has shown bacteriostatic effects against both gram-positive and gram-negative bacteria; however, the physicochemical interactions between Si3N4 and bacteria yet remain conspicuously unexplored. In situ time-lapse Raman spectroscopic experiments were conducted by exposing S...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29739248/cable-plating-with-a-single-strut-allograft-in-the-treatment-of-periprosthetic-fractures-of-the-femur-cable-plating-and-single-strut-allograft-in-periprosthetic-femur-fractures
#11
Jonathan R Manara, John A Mathews, Harvey S Sandhu
BACKGROUND: Hip arthroplasties are increasing worldwide resulting in an increasing number of periprosthetic fractures. These fractures are difficult to treat with various the different fixation or revision options described, many of which have high complication rates. PURPOSE: To investigate whether our described method of treating periprosthetic fractures is an effective, safe and reproducible method of treating patients. METHODS: We describe the largest series of a cable plate fixation system combined with a single cortical strut allograft to treat patients with periprosthetic fractures of the hip (Unified Classification System B1 and selected B2, C and D)...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29729819/one-year-after-proximal-or-distal-periprosthetic-fracture-of-the-femur-two-conditions-with-divergent-outcomes
#12
D Eschbach, B Buecking, H Kivioja, M Fischer, T Wiesmann, R Zettl, L Oberkircher, J Barthel, R Aigner, S Ruchholtz, C Bliemel
INTRODUCTION: Arthroplasty of the hip and knee is 1 of the 20 most frequent operations in Germany. Periprosthetic fracture is one of the most feared complications following primary or revision arthroplasty. Present publication aims to analyse differences between patients with periprosthetic fracture around total knee arthroplasty (PFTKA) and patients with periprosthetic fracture around total hip arthroplasty (PFTHA) concerning demographics, clinical course, complications and return to pre-fracture mobility...
April 24, 2018: Injury
https://www.readbyqxmd.com/read/29715226/development-and-evaluation-of-a-preoperative-risk-calculator-for-periprosthetic-joint-infection-following-total-joint-arthroplasty
#13
Timothy L Tan, Mitchell G Maltenfort, Antonia F Chen, AliSina Shahi, Carlos A Higuera, Marcelo Siqueira, Javad Parvizi
BACKGROUND: Preoperative identification of patients at risk for periprosthetic joint infection (PJI) following total hip arthroplasty (THA) or total knee arthroplasty (TKA) is important for patient optimization and targeted prevention. The purpose of this study was to create a preoperative PJI risk calculator for assessing a patient's individual risk of developing (1) any PJI, (2) PJI caused by Staphylococcus aureus, and (3) PJI caused by antibiotic-resistant organisms. METHODS: A retrospective review was performed of 27,717 patients (12,086 TKAs and 31,167 THAs), including 1,035 with confirmed PJI, who were treated at a single institution from 2000 to 2014...
May 2, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29715222/alpha-defensin-lateral-flow-test-for-diagnosis-of-periprosthetic-joint-infection-not-a-screening-but-a-confirmatory-test
#14
Nora Renz, Katsiaryna Yermak, Carsten Perka, Andrej Trampuz
BACKGROUND: Determination of alpha defensin in synovial fluid has shown promising results for diagnosing periprosthetic joint infection (PJI). The purposes of our study were to assess the performance of alpha defensin lateral flow (ADLF) test for the diagnosis of acute and chronic PJI using 3 classification systems and to compare its performance with the synovial fluid leukocyte count. METHODS: Patients in whom aspiration of a prosthetic hip or knee joint was performed before revision arthroplasty were prospectively included...
May 2, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29713837/current-options-and-emerging-biomaterials-for-periprosthetic-joint-infection
#15
REVIEW
Ashley E Levack, Erika L Cyphert, Mathias P Bostrom, Christopher J Hernandez, Horst A von Recum, Alberto V Carli
PURPOSE OF REVIEW: Infection in the setting of total joint arthroplasty, referred to as periprosthetic joint infection (PJI), is a devastating complication requiring prolonged and costly treatment. The unique environment around an artificial joint and ability of surrounding tissues to sequester bacteria collectively make prevention, diagnosis, and treatment of this condition challenging. In light of the unique pathogenesis of PJI, this review explores the limitations of contemporary treatments and discusses novel treatment options...
April 30, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29706257/primary-total-knee-arthroplasty-in-patients-with-neuropathic-charcot-arthropathy-contemporary-results
#16
Meagan E Tibbo, Brian P Chalmers, Daniel J Berry, Mark W Pagnano, David G Lewallen, Matthew P Abdel
BACKGROUND: Total knee arthroplasty (TKA) for neuropathic (Charcot) arthropathy is technically challenging with higher complication rates than primary TKA for osteoarthritis. There is a paucity of data regarding outcomes of TKA in contemporary cohorts with modern implants, techniques, and indications. Our study aimed to determine the (1) survivorship of implants, (2) rates and types of complications, (3) clinical outcomes, and (4) radiographic outcomes in patients treated with primary TKA for Charcot arthropathy...
April 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29702663/meta-analysis-of-sonication-prosthetic-fluid-pcr-for-diagnosing-periprosthetic-joint-infection
#17
Kan Liu, Jun Fu, Baozhan Yu, Wei Sun, Jiying Chen, Libo Hao
Periprosthetic joint infection (PJI) is a catastrophic complication following total joint arthroplasty. Until now, the diagnosis of PJI is still confronted with difficulties, which is characterized by technical limitations. The question of whether sonication fluid PCR can provide high value in the diagnosis of PJI remains unanswered. This meta-analysis included 9 studies that evaluated PCR assays of sonication fluid for the diagnosis of PJI. The pooled sensitivity, specificity, Positive likelihood ratio (PLR), Negative likelihood ratio (NLR) and Diagnostic odds ratio (DOR) were 0...
2018: PloS One
https://www.readbyqxmd.com/read/29695923/antibiotic-sensitivities-of-coagulase-negative-staphylococci-and-staphylococcus-aureus-in-hip-and-knee-periprosthetic-joint-infections-does-this-differ-if-patients-meet-the-international-consensus-meeting-criteria
#18
Elena De Vecchi, David A George, Carlo L Romanò, Fabrizio E Pregliasco, Roberto Mattina, Lorenzo Drago
Introduction: Coagulase-negative staphylococci (CoNS) are the main pathogens responsible for prosthetic joint infections (PJIs). As normal inhabitants of human skin, it is often difficult to define if they are contaminants, or if they have an active role in initiating infection. This study aims to evaluate differences in CoNS organisms ( Staphylococcus hominis, Staphylococcus capitis , Staphylococcus haemolyticus , Staphylococcus warneri) and Staphylococcus aureus in terms of isolation rate and antimicrobial susceptibility from patients who met the International Consensus Meeting (ICM) criteria for PJIs and those who did not...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29691603/-periprosthetic-hip-tep-infections-after-dental-procedures-maybe-an-indication-for-antibiotic-treatment-after-all
#19
Andreas Thiery, Konstantinos Anagnostakos
Periprosthetic infections are hazardous complications. After dental procedures, an antibiotic prophylaxis or treatment is actually not recommended according to the current guidelines. In the present work, a case of a hematogenous late infection after primary total hip arthroplasty due to a prior dental procedure is presented. Hereby, the question evolves as to whether in selected cases an antibiotic prophylaxis or treatment might be indicated at the site of dental procedures.
April 24, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29691335/novel-insights-into-staphylococcus-aureus-deep-bone-infections-the-involvement-of-osteocytes
#20
Dongqing Yang, Asiri R Wijenayaka, Lucian B Solomon, Stephen M Pederson, David M Findlay, Stephen P Kidd, Gerald J Atkins
Periprosthetic joint infection (PJI) is a potentially devastating complication of orthopedic joint replacement surgery. PJI with associated osteomyelitis is particularly problematic and difficult to cure. Whether viable osteocytes, the predominant cell type in mineralized bone tissue, have a role in these infections is not clear, although their involvement might contribute to the difficulty in detecting and clearing PJI. Here, using Staphylococcus aureus , the most common pathogen in PJI, we demonstrate intracellular infection of human-osteocyte-like cells in vitro and S...
April 24, 2018: MBio
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