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Ethanol intake

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https://www.readbyqxmd.com/read/28715389/extraction-and-purification-of-polyphenols-from-freeze-dried-berry-powder-for-the-treatment-of-vascular-smooth-muscle-cells-in-vitro
#1
Rafaela G Feresin, Shirin Pourafshar, Jingwen Huang, Yitong Zhao, Bahram H Arjmandi, Gloria Salazar
Epidemiological studies indicate that increased flavonoid intake correlates with decreased mortality due to cardiovascular diseases (CVD) in the United States (US) and Europe. Berries are widely consumed in the US and have a high polyphenolic content. Polyphenols have been shown to interact with many molecular targets and to exert numerous positive biological functions, including antioxidant, anti-inflammatory, and cardioprotective effects. Polyphenols isolated from blackberry (BL), raspberry (RB), and black raspberry (BRB) reduce oxidative stress and cellular senescence in response to angiotensin II (Ang II)...
July 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714806/loss-of-control-over-the-ethanol-consumption-differential-transcriptional-regulation-in-prefrontal-cortex
#2
Carolina de Paiva Lima, Daniel Almeida da Silva E Silva, Samara Damasceno, Andrea Frozino Ribeiro, Cristiane S Rocha, Alexandre H Berenguer de Matos, Diego Correia, Roseli Boerngen-Lacerda, Ana Lúcia Brunialti Godard
Alcohol use disorder (AUD) is a complex multifactorial disease with heritability of ∼50% and corresponds to the state in which the body triggers a reinforcement or reward compulsive behavior due to ethanol consumption, even when faced with negative consequences. Although several studies have shown the impact of high ethanol intake on the prefrontal cortex (PFC) gene expression, few have addressed the relationship between the patterns of gene expression underlying the compulsive behaviour associated with relapsing...
July 17, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28708332/oxidative-stress-and-cellular-and-tissue-damage-in-organogenic-outbred-mouse-embryos-after-moderate-perigestational-alcohol-intake
#3
Tamara A Coll, Gabriela Chaufan, Leticia Pérez-Tito, Martín R Ventureira, Cristian M A Sobarzo, María Del Carmen Ríos de Molina, Elisa Cebral
Perigestational alcohol consumption by CF-1 mouse, from before mating up to the period of embryo organogenesis, leads to retarded early embryo development and neural tube defects. Here, we addressed if perigestational alcohol ingestion up to Day 10 of pregnancy induces oxidative stress and changes in macromolecules and organ tissues of early organogenic embryos. Adult CF-1 female mice were administered 10% ethanol in their drinking water for 17 days prior to mating and until Day 10 of gestation, whereas control females were administered ethanol-free water...
July 14, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28705945/alcohol-consumption-as-a-risk-factor-for-tuberculosis-meta-analyses-and-burden-of-disease
#4
Sameer Imtiaz, Kevin D Shield, Michael Roerecke, Andriy V Samokhvalov, Knut Lönnroth, Jürgen Rehm
Meta-analyses of alcohol use, alcohol dosage and alcohol-related problems as risk factors for tuberculosis incidence were undertaken. The global alcohol-attributable tuberculosis burden of disease was also re-estimated.Systematic searches were conducted, reference lists were reviewed and expert consultations were held to identify studies. Cohort and case-control studies were included if there were no temporal violations of exposure and outcome. Risk relations (RRs) were pooled by using categorical and dose-response meta-analyses...
July 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28693325/transparent-silk-fibroin-microspheres-from-controlled-droplet-dissolution-in-a-binary-solution
#5
Fernando Javita, Xuehua Zhang
Silk is a natural polymer with a broad range of potential applications in textile, advanced materials, biomedical devices and drug delivery. The ability to control the morphology and assembly of silk fibroin is essential for fabrication of silk-based structured materials. Here we report an effective and simple approach based on droplet dissolution for weaving silk fibroin into spheres of several hundred micrometers in diameter. The spheres possess regular wrinkled microstructures on the surface and switchable transparency for visible light...
July 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28679148/intermittent-access-to-ethanol-drinking-facilitates-the-transition-to-excessive-drinking-after-chronic-intermittent-ethanol-vapor-exposure
#6
Adam Kimbrough, Sarah Kim, Maury Cole, Molly Brennan, Olivier George
BACKGROUND: Alcohol binge drinking in humans is thought to increase the risk for alcohol use disorder (AUD). Unclear is whether drinking patterns (e.g., bingelike or stable drinking) differentially affect the transition to compulsive-like drinking in dependent individuals. We examined whether chronic bingelike drinking facilitates the transition to compulsive-like drinking in rats. METHODS: Male Wistar rats were given 5 months of intermittent access to ethanol (EtOH) (IAE) or continuous access to EtOH (CAE) in a 2-bottle choice paradigm...
July 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28675777/effects-of-myricetin-containing-ethanol-solution-on-high-fat-diet-induced-obese-rats
#7
Hsueh-Chin Chao, Pei-Feng Tsai, Sheng-Chi Lee, Yeong-Shenn Lin, Ming-Chang Wu
Myricetin is a natural flavonol widely occurring in wines. Many beneficial effects of myricetin in alcoholic beverages have been reported before, but never including anti-obesity. In the present study, we fed obese male Sprague-Dawley rats with ethanol solutions containing various concentrations of myricetin and found that myricetin may maintain the food intake while reduce the weight-gain, feed efficiency, level of blood lipids, adipocyte size, and weight and size of the perirenal and epididymal adipose tissues (P < 0...
July 4, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28674997/adolescent-binge-alcohol-exposure-affects-the-brain-function-through-mitochondrial-impairment
#8
Cheril Tapia-Rojas, Francisco J Carvajal, Rodrigo G Mira, Camila Arce, José Manuel Lerma-Cabrera, Juan A Orellana, Waldo Cerpa, Rodrigo A Quintanilla
In the young population, binge drinking is a pattern of problematic alcohol consumption, characterized by a short period of heavy drinking followed by abstinence which is frequently repeated over time. This drinking pattern is associated with mental problems, use of other drugs, and an increased risk of excessive alcohol intake during adulthood. However, little is known about the effects of binge drinking on brain function in adolescents and its neurobiological impact during the adulthood. In the present study, we evaluated the effects of alcohol on hippocampal memory, synaptic plasticity, and mitochondrial function in adolescent rats after a binge drinking episode in vivo...
June 1, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28663116/short-term-selection-for-high-and-low-ethanol-intake-yields-differential-sensitivity-to-ethanol-s-motivational-effects-and-anxiety-like-responses-in-adolescent-wistar-rats
#9
Macarena Soledad Fernández, Bárbara Báez, Ana Bordón, Laura Espinosa, Eliana Martínez, Ricardo Marcos Pautassi
Alcohol use disorders are modulated by genetic factors, but the identification of specific genes and their concomitant biological changes that are associated with a higher risk for these disorders has proven difficult. Alterations in the sensitivity to the motivational effects of ethanol may be one way by which genes modulate the initiation and escalation of ethanol intake. Rats and mice have been selectively bred for high and low ethanol consumption during adulthood. However, selective breeding programs for ethanol intake have not focused on adolescence...
June 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28656742/long-term-subregion-specific-encoding-of-enhanced-ethanol-intake-by-d1dr-medium-spiny-neurons-of-the-nucleus-accumbens
#10
Rafael Renteria, Tavanna R Buske, Richard A Morrisett
The nucleus accumbens (NAc) is a critical component of the mesocorticolimbic system and is involved in mediating the motivational and reinforcing aspects of ethanol consumption. Chronic intermittent ethanol (CIE) exposure is a reliable model to induce ethanol dependence and increase volitional ethanol consumption in mice. Following a CIE-induced escalation of ethanol consumption, NMDAR (N-methyl-D-aspartate receptor)-dependent long-term depression in D1 dopamine receptor expressing medium spiny neurons of the NAc shell was markedly altered with no changes in plasticity in D1 dopamine receptor medium spiny neurons from the NAc core...
June 28, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28649077/hepatoprotective-evaluation-of-aqueous-ethanolic-extract-of-capparis-decidua-stems-in-paracetamol-induced-hepatotoxicity-in-experimental-rabbits
#11
Jalilur Rehman, Naveed Akhtar, Hafiz Muhammad Asif, Sabira Sultana, Mukhtiar Ahmad
Liver diseases are the most common ailment all over the world mostly caused by viruses, toxic chemicals, excessive intake of alcohol, high doses of paracetamol, carbon tetrachloride, chemotherapeutic agents and peroxides oil, etc. There is a great need to assess the scientific basis for the medicinal plants that are claimed to have hepatoprotective activity. We investigate the hepatoprotective effects of aqueous-ethanolic extract of Capparis decidua (Stems) against paracetamol induced liver injury in experimental animals...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28638432/mechanical-stimulation-of-the-ht7-acupuncture-point-to-reduce-ethanol-self-administration-in-rats
#12
Suk-Yun Kang, O Sang Kwon, Ji-Young Moon, Seong Jin Cho, Kwang-Ho Choi, Junbeom Kim, Seong-Hun Ahn, Yeonhee Ryu
BACKGROUND: Alcoholism, which is a disabling addiction disorder, is a major public health problem worldwide. The present study was designed to determine whether the application of acupuncture at the Shenmen (HT7) point suppresses voluntary alcohol consumption in addicted rats and whether this suppressive effect is potentiated by the administration of naltrexone. METHODS: Rats were initially trained to self-administer a sucrose solution by operating a lever. A mechanical acupuncture instrument (MAI) for objective mechanical stimulation was used on rats whose baseline response had been determined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28623169/mutation-of-the-inhibitory-ethanol-site-in-gabaa-%C3%AF-1-receptors-promotes-tolerance-to-ethanol-induced-motor-incoordination
#13
Yuri A Blednov, Cecilia M Borghese, Carlos I Ruiz, Madeline A Cullins, Adriana Da Costa, Elizabeth A Osterndorff-Kahanek, Gregg E Homanics, R Adron Harris
Genes encoding the ρ1/2 subunits of GABAA receptors have been associated with alcohol (ethanol) dependence in humans, and ρ1 was also shown to regulate some of the behavioral effects of ethanol in animal models. Ethanol inhibits GABA-mediated responses in wild-type (WT) ρ1, but not ρ1(T6'Y) mutant receptors expressed in Xenopus laevis oocytes, indicating the presence of an inhibitory site for ethanol in the second transmembrane helix. In this study, we found that ρ1(T6'Y) receptors expressed in oocytes display overall normal responses to GABA, the endogenous GABA modulator (zinc), and partial agonists (β-alanine and taurine)...
June 13, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28603116/anti-diabetic-and-hypolipidemic-effects-of-extract-from-the-seed-of-gossypium-herbaceum-l-in-alloxan-induced-diabetic-rabbits
#14
Rifat Uzzaman, Maida Ghaffar
Anti-diabetic and hypolipidemic effects of seed of Gossypium herbaceum L (GH) and its aqueous and ethanol extracts were investigated in alloxan-induced diabetic rabbits. Normal, Alloxan-induced diabetic and treated groups of rabbit were examined for their serum glucose, triglyceride, cholesterol, creatinine and urea levels. Water/food intake and toxic effect of test substances were also observed in treated rabbits. Effect of test agents on architecture of pancreatic β-cells was evaluated histopathologically in rabbits...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28599714/effects-of-moderate-alcohol-consumption-on-gene-expression-related-to-colonic-inflammation-and-antioxidant-enzymes-in-rats
#15
DawnKylee S Klarich, Jerrold Penprase, Patricia Cintora, Octavio Medrano, Danielle Erwin, Susan M Brasser, Mee Young Hong
Excessive alcohol consumption is a risk factor associated with colorectal cancer; however, some studies have reported that moderate alcohol consumption may not contribute additional risk for developing colorectal cancer while others suggest that moderate alcohol consumption provides a protective effect that reduces colorectal cancer risk. The purpose of this study was to determine the effects of moderate voluntary alcohol (20% ethanol) intake on alternate days for 3 months in outbred Wistar rats on risk factors associated with colorectal cancer development...
June 2017: Alcohol
https://www.readbyqxmd.com/read/28591773/ethyl-glucuronide-elimination-kinetics-in-fingernails-and-comparison-to-levels-in-hair
#16
Jan Toralf Fosen, Luca Morini, Cristina Sempio, Nefele Giarratana, Asle Enger, Jørg Mørland, Gudrun Høiseth
Aims: Measurement of ethyl glucuronide (EtG) in nail, as a biomarker for alcohol intake, has recently been suggested as alternative to measurement in hair. The aim of this study was to compare levels of EtG in nail and hair, and to investigate the elimination kinetics of EtG in fingernails during an alcohol abstinent period. Methods: Overall, 40 subjects (median estimated daily intake of ethanol (EDI) 92.5 g/day) were recruited from an alcohol rehabilitation clinic...
June 7, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28589264/habitual-nicotine-seeking-in-rats-following-limited-training
#17
A Loughlin, D Funk, K Coen, A D Lê
RATIONALE AND OBJECTIVES: A potential reason that cigarette smoking can persist despite multiple quit attempts is that repeated voluntary nicotine intake may facilitate a transition from goal-directed to habitual behavioral control. Although accelerated habit formation for self-administered ethanol or cocaine has been previously demonstrated, this phenomenon has not been extensively studied with nicotine. We therefore examined the liability of nicotine self-administration to become habitual, while also examining that of orally consumed saccharin as an experimental control...
June 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28588461/modulation-of-ethanol-metabolizing-enzymes-by-developmental-lead-exposure-effects-in-voluntary-ethanol-consumption
#18
Miriam B Virgolini, Mara S Mattalloni, Paula A Albrecht, Romina Deza-Ponzio, Liliana M Cancela
This review article provides evidence of the impact of the environmental contaminant lead (Pb) on the pattern of the motivational effects of ethanol (EtOH). To find a mechanism that explains this interaction, the focus of this review article is on central EtOH metabolism and the participating enzymes, as key factors in the modulation of brain acetaldehyde (ACD) accumulation and resulting effect on EtOH intake. Catalase (CAT) seems a good candidate for the shared mechanism between Pb and EtOH due to both its antioxidant and its brain EtOH-metabolizing properties...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28578603/aav-gene-therapy-for-alcoholism-inhibition-of-mitochondrial-aldehyde-dehydrogenase-enzyme-expression-in-hepatoma-cells
#19
Anamaria C Sanchez, Chengwen Li, Barbara Andrews, Juan A Asenjo, R Jude Samulski
Most ethanol is broken down in the liver in two steps by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) enzymes, which metabolize down ethanol into acetaldehyde and then acetate. Some individuals from the Asian population who carry a mutation in the aldehyde dehydrogenase gene (ALDH2*2) cannot metabolize acetaldehyde as efficiently, producing strong effects, including facial flushing, dizziness, hypotension, and palpitations. This results in an aversion to alcohol intake and protection against alcoholism...
June 2, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28572922/migration-of-nonylphenol-and-plasticizers-from-polyvinyl-chloride-stretch-film-into-food-simulants-rapeseed-oil-and-foods
#20
Yoko Kawamura, Yuko Ogawa, Motoh Mutsuga
Nonylphenol (NP) has been suspected as an endocrine-disrupting chemical. Japanese polyvinyl chloride (PVC) stretch films contained 0.5-3.3 mg/g of NP and 100-400 mg/g of plasticizers such as diisononyl adipate (DINA), di-n-alkyl adipate (DAA), and diacetyllauroyl glycerol (DALG). Migration of NP and plasticizers from PVC stretch films into food simulants (water; 4% acetic acid; 20%, 50%, and 95% ethanol; and heptane), rapeseed oil, and foods was investigated. Plasticizers migrated only in small amounts into aqueous simulants and foods, although they migrated at much higher levels into 50% and 95% ethanol, heptane, rapeseed oil, and fatty foods, whereas NP more easily migrated into aqueous simulants and foods...
May 2017: Food Science & Nutrition
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