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Ethanol intake

Jimena Laura Frontera, Victoria María Gonzalez Pini, Fernando Luis Messore, Alicia Brusco
The endocannabinoid (eCB) system is involved in the modulation of the reward system and participates in the reinforcing effects of different drugs of abuse, including alcohol. The most abundant receptor of the eCB system in the central nervous system is the CB1 receptor (CB1R), which is predominantly expressed in areas involved in drug addiction, such as the nucleus accumbens, the ventral tegmental area, the substantia nigra and the raphe nucleus. CB1R is expressed in early stages during development, and reaches maximum levels during early adolescence...
May 16, 2018: Neuropharmacology
Phillip R Zoladz, Eric D Eisenmann, Robert M Rose, Brooke A Kohls, Brandon L Johnson, Kiera L Robinson, Megan E Heikkila, Kasey E Mucher, Madelaine R Huntley
Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder typified by diagnostic symptom clusters including hyperarousal, avoidance, negative cognitions and mood, and intrusive re-experiencing of the traumatic event. Patients with PTSD have been reported to self-medicate with alcohol to ameliorate hyperarousal symptoms associated with the disorder. Research utilizing rodent models of PTSD to emulate this behavioral phenomenon has thus far yielded inconsistent results. In the present study, we examined the effects of a predator-based psychosocial stress model of PTSD on voluntary ethanol consumption...
January 8, 2018: Alcohol
Chikako Shimizu, Yutaka Mitani, Youichi Tsuchiya, Toshitaka Nabeshima
Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with alcohol. Therefore, we investigated the association among oral Ca ingestion, EtOH-induced locomotor sensitization, and plasma Ca levels on how to consume Ca for moderate drinking. We used DBA/2 CrSlc mice, and CaCl2 as water-soluble Ca salts...
May 16, 2018: Biological & Pharmaceutical Bulletin
Reese D Kennedy, Adriana Cheavegatti-Gianotto, Wladecir S de Oliveira, Ronald P Lirette, Jerry J Hjelle
Insect-protected sugarcane that expresses Cry1Ab has been developed in Brazil. Analysis of trade information has shown that effectively all the sugarcane-derived Brazilian exports are raw or refined sugar and ethanol. The fact that raw and refined sugar are highly purified food ingredients, with no detectable transgenic protein, provides an interesting case study of a generalized safety assessment approach. In this study, both the theoretical protein intakes and safety assessments of Cry1Ab, Cry1Ac, NPTII, and Bar proteins used in insect-protected biotechnology crops were examined...
2018: Frontiers in Bioengineering and Biotechnology
Luanna M P Fernandes, Sabrina C Cartágenes, Mayara A Barros, Taiana C V S Carvalheiro, Nair Correia de Freitas Castro, Marissa G Schamne, Rafael R Lima, Rui D Prediger, Marta C Monteiro, A F Enéas, Rodrigo A Cunha, Cristiane S F Maia
Binge-like ethanol intake (BEI) is a socioeconomical problem among adolescents and increasingly affects women. BEI can leave a long-term imprint in the brain, but it is unknown if its effect on cognition and anxiety is cumulative on repeated binge-ethanol episodes. We now submitted female Wistar rats to repeated cycles of binge-like ethanol treatment by intragastrically administering ethanol (3.0 g/kg/day, 20% w/v ethanol; 3 days on/4 days off) starting at postnatal day 35 (PND35). To investigate the short-term effects of BEI during adolescence, rats underwent 1 or 4 cycles of BEI, being evaluated at PND37 and PND58, respectively: both groups displayed anxiety-like behavior in the open field and elevated plus-maze tests, as well as short-term memory deficits in the object recognition task; this was associated with transient decreases of BDNF levels and increases of GFAP levels in the hippocampus...
May 9, 2018: Behavioural Brain Research
M L Jolly-Breithaupt, B L Nuttelman, C J Schneider, D B Burken, J L Gramkow, A L Shreck, J C MacDonald, T J Klopfenstein, G E Erickson
Three experiments evaluated the effects of corn oil removal using centrifugation in ethanol plants, on animal performance and digestion characteristics by finishing cattle fed by-products. In Exp. 1, 225 crossbred steers (300 ± 9.1 kg) were utilized in a randomized block design with a 2 × 2 + 1 factorial arrangement of treatments. Factors consisted of oil concentration [de-oiled (DO) or full fat (FF)] and by-product type [condensed distillers solubles (CDS) or modified distillers grains plus solubles (MDGS)] compared to a corn-based control...
May 4, 2018: Journal of Animal Science
Guerzoni Simona, Pellesi Lanfranco, Pini Luigi Alberto, Caputo Fabio
Drug interactions are one of the most common causes of side effects in polypharmacy. Alcoholics are a category of patients at high risk of pharmacological interactions, due to the presence of comorbidities, the concomitant intake of several medications and the pharmacokinetic and pharmacodynamic interferences of ethanol. However, the data available on this issue are limited. These reasons often frighten clinicians when prescribing appropriate pharmacological therapies for alcohol use disorder (AUD), where less than 15% of patients receive an appropriate treatment in the most severe forms...
April 29, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Jérôme Jeanblanc, Erika Bourguet, Diana Sketriené, Céline Gonzalez, Gautier Moroy, Rémi Legastelois, Mathieu Létévé, Aurélie Trussardi-Régnier, Mickaël Naassila
RATIONALE: Recent preclinical research suggested that histone deacetylase inhibitors (HDACIs) and specifically class I HDAC selective inhibitors might be useful to treat alcohol use disorders (AUDs). OBJECTIVE: The objective of this study was to find a new inhibitor of the HDAC-1 isoenzyme and to test its efficacy in an animal model of AUDs. METHODS: In the present study, we prepared new derivatives bearing sulfonylhydrazide-type zinc-binding group (ZBG) and evaluated these compounds in vitro on HDAC-1 isoenzyme...
April 30, 2018: Psychopharmacology
Nnamdi G Nelson, Faten A Suhaidi, Wen Xuan Law, Nu-Chu Liang
Because the consumption of alcoholic beverages prevails in society, its effects on diabetes risk is a subject of interest. Extant literature on this issue often disagrees. Here, we probed the effects of chronic moderate ethanol consumption on glucose metabolism in rats. The effect of chronic moderate alcohol drinking on depression- and anxiety-like behaviors and memory was also explored. Adolescent male and female Long-Evans rats consumed saccharin-sweetened 5% (1 week) and 10% ethanol (7 weeks) under a 7.5-h/day (Monday-Friday) access schedule...
December 16, 2017: Alcohol
Colin T Shearn, Casey F Pulliam, Kim Pedersen, Kyle Meredith, Kelly E Mercer, Laura M Saba, David J Orlicky, Martin J Ronis, Dennis R Petersen
BACKGROUND: Glutathione-S-transferase A4-4 (GSTA4) is a key enzyme for removal of toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE). In the current study, we examined the potential role of GSTA4 on protein carbonylation and progression of alcoholic liver disease (ALD) by examining the development of liver injury in male wild type SV/J mice (WT) and SV/J mice lacking functional GSTA4 (GSTA4-/- mice). METHODS: Adult male WT and GSTA4-/- mice were fed chow (N = 10-12) or high fat Lieber-DeCarli liquid diets containing up to 28% calories as ethanol (EtOH) (N = 18-20) for 116 days...
April 30, 2018: Alcoholism, Clinical and Experimental Research
Rashidi M Pakri Mohamed, Mohd H Mokhtar, Ernie Yap, Athirah Hanim, Norhazlina Abdul Wahab, Farah H F Jaffar, Jaya Kumar
The long-term binge intake of ethanol causes neuroadaptive changes that lead to drinkers requiring higher amounts of ethanol to experience its effects. This neuroadaptation can be partly attributed to the modulation of numerous neurotransmitter receptors by the various protein kinases C (PKCs). PKCs are enzymes that control cellular activities by regulating other proteins via phosphorylation. Among the various isoforms of PKC, PKCε is the most implicated in ethanol-induced biochemical and behavioral changes...
2018: Frontiers in Neuroscience
Yu Zhang, Quan Jin, Xia Li, Jiang Min, Ben-Wen Cui, Kai-Li Xia, Yan-Ling Wu, Li-Hua Lian, Ji-Xing Nan
Dihydroquercetin (TAX) is the most abundant dihydroflavone found in onions, milk thistle and Douglas fir bark. We investigated whether TAX could inhibit the lipid accumulation in alcoholic liver steatosis in vivo and in vitro. An in vivo model was established by intragastrically treating mice with ethanol, and an in vitro model was created by treating HepG2 cells with ethanol. TAX regulated SREBP1 and ACC expression via elevating LKB1/AMPK phosphorylation. Also, TAX upregulated SIRT1 expression, which suppressed by ethanal intake...
April 28, 2018: Journal of Agricultural and Food Chemistry
Yonglin Chen, Xinshou Ouyang, Rafaz Hoque, Irma Garcia-Martinez, Muhammad Nadeem Yousaf, Sarah Tonack, Stefan Offermanns, Laurent Dubuquoy, Alexandre Louvet, Philippe Mathurin, Veronica Massey, Bernd Schnabl, Ramon A Bataller, Wajahat Zafar Mehal
BACKGROUND & AIMS: Sterile inflammation resulting in alcohol hepatitis (AH) occurs unpredictably after many years of excess alcohol intake. The factors responsible for the development of AH are not known but mitochondrial damage with loss of mitochondrial function are common features. Hcar2 is a G-protein coupled receptor which is activated by β-hydroxybutyrate (BHB), and the relevance of the BHB-Hcar2 pathway in alcoholic liver disease is not known. METHODS: We tested if loss of BHB production can result in increased liver inflammation...
April 26, 2018: Journal of Hepatology
Gabriel Quiroz, Nicolás Guerra-Díaz, Patricio Iturriaga-Vásquez, Mario Rivera-Meza, María Elena Quintanilla, Ramón Sotomayor-Zárate
Alcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol dependence. In this work, we assess the effectiveness of four doses of erysodine (1.5, 2.0, 4.0 or 8.0 mg/kg/day, i.p.), a competitive antagonist of nAChRs, on voluntary ethanol consumption behavior in alcohol-preferring UChB rats, administered during three consecutive days. Results show that erysodine administration produces a dose-dependent reduction in ethanol consumption respect to saline injection (control group)...
April 25, 2018: Behavioural Brain Research
Rutuja Yawalkar, Harish Changotra, Girdhari Lal Gupta
Evidences have indicated a high degree of comorbidity of alcoholism and depression. N-acetylcysteine (NAC) has shown its clinical efficiency in the treatment of several psychiatric disorders and is identified as a multi-target acting drug. The ability of NAC to prevent alcohol abstinence-induced depression-like effects and underlying mechanism(s) have not been adequately addressed. This study was aimed to investigate the beneficial effects of NAC in the alcohol abstinence-induced depression developed following long-term voluntary alcohol intake...
April 25, 2018: Neurochemistry International
Brandilyn A Peters, Marjorie L McCullough, Mark P Purdue, Neal D Freedman, Caroline Y Um, Susan M Gapstur, Richard B Hayes, Jiyoung Ahn
BACKGROUND: The oral microbiota play a central role in oral health, and possibly in carcinogenesis. Research suggests coffee and tea consumption may have beneficial health effects. We examined the associations of these common beverages with the oral ecosystem in a large cross-sectional study. METHODS: We assessed oral microbiota in mouthwash samples from 938 participants in two U.S. cohorts using 16S rRNA gene sequencing. Coffee and tea intake were assessed from food frequency questionnaires...
April 27, 2018: Cancer Epidemiology, Biomarkers & Prevention
Mario Lorenz, Jennifer Brade, Lisa Diamond, Daniel Sjölie, Marc Busch, Manfred Tscheligi, Philipp Klimant, Christoph-E Heyde, Niels Hammer
Virtual Reality (VR) is used for a variety of applications ranging from entertainment to psychological medicine. VR has been demonstrated to influence higher order cognitive functions and cortical plasticity, with implications on phobia and stroke treatment. An integral part for successful VR is a high sense of presence - a feeling of 'being there' in the virtual scenario. The underlying cognitive and perceptive functions causing presence in VR scenarios are however not completely known. It is evident that the brain function is influenced by drugs, such as ethanol, potentially confounding cortical plasticity, also in VR...
April 23, 2018: Scientific Reports
Paul Ruiz, Aldo Calliari, Ricardo Marcos Pautassi
Depression usually emerges during adolescence, is significantly more frequent in women, and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies assessing the link between depression and ethanol intake, however, have employed only males or relied on stress-induced depression, or induced the experimentally-induced, depressive-like phenotype, during adolescence yet measured ethanol intake at adulthood. This study assessed, in Wistar male and female adolescent rats, the effects of inducing experimental depression (via administration of 1...
April 20, 2018: Behavioural Brain Research
Hideki Okata, Waku Hatta, Katsunori Iijima, Kiyotaka Asanuma, Atsuki Tsuruya, Naoki Asano, Tomoyuki Koike, Shin Hamada, Toru Nakayama, Atsushi Masamune, Tooru Shimosegawa
Ethanol is oxidized by alcohol dehydrogenase to acetaldehyde, a recognized carcinogen for the esophagus. However, no previous study has measured the acetaldehyde levels in the esophageal tissue. L-cysteine has been shown to reduce the acetaldehyde levels in the saliva; however, it is unknown whether L-cysteine intake affects the acetaldehyde concentration in the esophageal tissue. The aim of this study was to measure the acetaldehyde concentration in the esophageal tissue after ethanol drinking and evaluate the effect of L-cysteine intake on the acetaldehyde levels in the esophagus...
2018: Tohoku Journal of Experimental Medicine
Maytiya Konkit, Kiyoung Kim, Jong-Hwa Kim, Wonyong Kim
In this study, we investigated the beneficial effects of Lactococcus chungangensis CAU 28, a bacterial strain of nondairy origin, on alcohol metabolism in rats treated with ethanol, focusing on alcohol elimination and prevention of damage and comparing the effects with those observed for Lactococcus lactis ssp. lactis ATCC 19435. Male Sprague-Dawley rats were orally administered 20% ethanol and 3 substrates (freeze-dried cells, cream cheese, and yogurt) containing Lc. chungangensis CAU 28 or Lc. lactis ssp...
April 19, 2018: Journal of Dairy Science
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