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Ethanol intake

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https://www.readbyqxmd.com/read/29168269/adolescent-ethanol-intake-alters-cannabinoid-type-1-receptor-localization-in-astrocytes-of-the-adult-mouse-hippocampus
#1
Itziar Bonilla-Del Rίo, Nagore Puente, Sara Peñasco, Irantzu Rico, Ana Gutiérrez-Rodrίguez, Izaskun Elezgarai, Almudena Ramos, Leire Reguero, Inmaculada Gerrikagoitia, Brian R Christie, Patrick Nahirney, Pedro Grandes
Cannabinoid type-1 (CB1 ) receptors are widely distributed in the brain and play important roles in astrocyte function and the modulation of neuronal synaptic transmission and plasticity. However, it is currently unknown how CB1 receptor expression in astrocytes is affected by long-term exposure to stressors. Here we examined CB1 receptors in astrocytes of ethanol (EtOH)-exposed adolescent mice to determine its effect on CB1 receptor localization and density in adult brain. 4-8-week-old male mice were exposed to 20 percent EtOH over a period of 4 weeks, and receptor localization was examined after 4 weeks in the hippocampal CA1 stratum radiatum by pre-embedding immunoelectron microscopy...
November 23, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29168193/the-effects-of-long-term-varenicline-administration-on-ethanol-and-sucrose-seeking-and-self-administration-in-male-p-rats
#2
Cristine L Czachowski, Janice C Froehlich, Michael DeLory
BACKGROUND: Varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic cholinergic receptors, is FDA approved for treatment of smoking cessation and has been found to reduce alcohol craving in clinical populations. In rodents, varenicline decreases free-choice ethanol intake with somewhat mixed findings in operant paradigms that utilize a combined appetitive/consummatory response. METHODS: The present experiment utilized an operant paradigm that procedurally separates appetitive from consummatory responding and a "reward blocking" approach (i...
November 23, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29166141/adherence-to-the-wcrf-aicr-for-women-in-breast-cancer-adjuvant-treatment-submitted-to-educational-nutritional-intervention
#3
Sheyla de Liz, Francilene Gracieli Kunradi Vieira, Maria Alice Altenburg de Assis, Alyne Lizane Cardoso, Clarice Perucchi Lopes Pazini, Patricia Faria Di Pietro
Patients undergoing breast cancer treatment are susceptible to changes in eating behavior and nutrition status, thus making nutrition education relevant. Based on the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guide, with recommendations for cancer prevention released in 2007, the present study aimed to evaluate the effectiveness of educational nutritional intervention for women with breast cancer undergoing treatment while adhering to the 2007 WCRF/AICR guidelines. A nonrandomized clinical trial was conducted with a population composed of female patients, divided in intervention (IG, n = 18) and comparison (CG, n = 68) groups...
November 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29158111/brain-derived-neurotrophic-factor-bdnf-determines-a-sex-difference-in-cue-conditioned-alcohol-seeking-in-rats
#4
Samuel J Hogarth, Emily J Jaehne, Maarten van den Buuse, Elvan Djouma
Alcohol use disorder is a detrimental addictive disease that develops through prolonged ethanol exposure and regular intoxication. However, the changes in the underlying neurobiology leading to alcohol addiction remain unclear. Brain-Derived Neurotrophic Factor (BDNF) is implicated in substance abuse disorders including alcoholism. As the vast majority of previous animal model studies have concentrated on males only, the aim of this study was to determine whether endogenous BDNF mediates alcohol seeking in a sex-specific manner...
November 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29155439/applications-and-challenges-for-the-use-of-phosphatidylethanol-testing-in-liver-disease-patients-mini-review
#5
Van Long Nguyen, Paul S Haber, Devanshi Seth
Phosphatidylethanol (PEth) is a direct non-oxidative metabolite of ethanol that may be measured in clinical samples as a marker for monitoring alcohol consumption. It has been used in a wide variety of clinical and non-clinical settings; however, its investigation in relation to liver disease has been limited. This paper aims at providing a short review on the applications and challenges for the incorporation of PEth testing in identifying alcohol intake in this patient population. This article is protected by copyright...
November 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29135074/effects-of-alcohol-on-plasma-glucose-and-prevention-of-alcohol-induced-hypoglycemia-in-type-1-diabetes-a-systematic-review-with-grade
#6
REVIEW
R Tetzschner, K Nørgaard, A Ranjan
BACKGROUND: Since ethanol is thought to be a risk factor for severe hypoglycemia, patients with type 1 diabetes (T1D) are recommended to limit ethanol intake. However, little is known on how ethanol affects plasma glucose and how ethanol-induced hypoglycemia can be prevented. In this study, we systematically reviewed the literature for ethanol effects on plasma glucose and for prevention strategies on ethanol-induced hypoglycemia. METHODS: Electronic searches on PubMed and Google were conducted in February 2017...
November 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29127890/the-role-of-ethyl-glucuronide-in-supporting-medico-legal-investigations-analysis-of-this-biomarker-in-different-postmortem-specimens-from-21-selected-autopsy-cases
#7
Anna Laura Santunione, Patrizia Verri, Filippo Marchesi, Cecilia Rustichelli, Federica Palazzoli, Daniele Vandelli, Manuela Licata, Enrico Silingardi
Ethanol determination in postmortem blood is one of the most frequently requested analyses in legal medicine and forensic toxicology. Ethyl glucuronide is a non-oxidative ethanol metabolite. It is also a useful marker of ante-mortem alcohol ingestion when ethanol itself has been completely eliminated from the body and could be considered in autopsy cases to obtain more reliable indications. The aim of the present study was to investigate the ethyl glucuronide distribution in postmortem specimens from autopsy cases found to be positive for ethanol...
November 1, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29121805/prostate-cancer-xenograft-inhibitory-activity-and-pharmacokinetics-of-decursinol-a-metabolite-of-angelica-gigas-pyranocoumarins-in-mouse-models
#8
Wei Wu, Su-Ni Tang, Yong Zhang, Manohar Puppala, Timothy K Cooper, Chengguo Xing, Cheng Jiang, Junxuan Lü
We have previously shown that the ethanol extract of dried Angelica gigas Nakai (AGN) root exerts anticancer activity against androgen receptor (AR)-negative human DU145 and PC-3 prostate cancer xenografts and primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The major pyranocoumarin isomers decursin (D) and decursinol angelate (DA), when provided at equi-molar intake to that provided by AGN extract, accounted for the inhibitory efficacy against precancerous epithelial lesions in TRAMP mice...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29118713/corticotropin-releasing-factor-in-the-bed-nucleus-of-the-stria-terminalis-in-socially-defeated-and-non-stressed-mice-with-a-history-of-chronic-alcohol-intake
#9
Lucas Albrechet-Souza, Thiago W Viola, Rodrigo Grassi-Oliveira, Klaus A Miczek, Rosa M M de Almeida
Stress exposure has been identified as one risk factor for alcohol abuse that may facilitate the transition from social or regulated use to the development of alcohol dependence. Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption. The bed nucleus of the stria terminalis (BNST) contains CRF-producing neurons which seem to be sensitive to stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29113896/neuroinflammation-produced-by-heavy-alcohol-intake-is-due-to-loops-of-interactions-between-toll-like-4-and-tnf-receptors-peroxisome-proliferator-activated-receptors-and-the-central-melanocortin-system-a-novel-hypothesis-and-new-therapeutic-avenues
#10
Osvaldo Flores-Bastías, Eduardo Karahanian
Excessive alcohol intake induces an inflammatory response in the brain, via TNFα, TLR4 and NF-κB signaling pathways. It has been proposed that neuroinflammation would play a very important role in the development of alcohol addiction. In addition to stimulating the synthesis of inflammatory mediators such as IL-6, IL-1β and TNFα, NF-κB is capable of reducing the anti-inflammatory activity of PPARα and PPARγ. Reciprocally, PPARα, PPARγ and melanocortin 4 receptor (MC4R) can decrease the proinflammatory activity of NF-κB, establishing an interplay of inactivations between such nuclear factors and receptors...
November 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29113737/voluntary-alcohol-intake-after-noise-exposure-in-adolescent-rats-hippocampal-related-behavioral-alterations
#11
M Miceli, S J Molina, A Forcada, G B Acosta, L R Guelman
Different physical or chemical agents, such as noise or alcohol, can induce diverse behavioral and biochemical alterations. Considering the high probability of young people to undergo a successive or simultaneous exposure, the aim of the present work was to investigate in an animal model if noise exposure at early adolescence could induce hippocampal-related behavioral changes that might be modified after alcohol intake. MaleWistarrats(28-days-old)were exposed tonoise(95-97 dB, 2 h).Afterwards, animals were allowed to voluntarily drink alcohol(10% ethanol in tap water)for three consecutive days, using the two-bottle free choice paradigm...
November 4, 2017: Brain Research
https://www.readbyqxmd.com/read/29112774/neuroactive-steroid-3%C3%AE-5%C3%AE-3-hydroxypregnan-20-one-3%C3%AE-5%C3%AE-thp-and-pro-inflammatory-cytokine-mcp-1-levels-in-hippocampus-ca1-are-correlated-with-voluntary-ethanol-consumption-in-cynomolgus-monkey
#12
Matthew C Beattie, Christopher S Reguyal, Patrizia Porcu, James B Daunais, Kathleen A Grant, A Leslie Morrow
BACKGROUND: Neuroactive steroids such as (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone) are potent neuromodulators that enhance GABAergic neurotransmission and produce inhibitory neurobehavioral and anti-inflammatory effects. Chronic ethanol consumption reduces 3α,5α-THP levels in human plasma, but has brain-region and species-specific effects on CNS levels of 3α,5α-THP. We explored the relationship between 3α,5α-THP levels in the hippocampus and voluntary ethanol consumption in the cynomolgus monkey following daily self-administration of ethanol for 12 months and further examined the relationship to HPA axis function prior to ethanol exposure...
November 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29111360/voluntary-binge-like-ethanol-consumption-site-specifically-increases-c-fos-immunoexpression-in-male-c57bl6-j-mice
#13
Nathan W Burnham, Todd E Thiele
The assessment of binge ethanol-induced neuronal activation, using c-Fos immunoreactivity (IR) as a marker of neuronal activity, is typically accomplished via forced ethanol exposure, such as intraperitoneal injection or gavage. Neuronal activity using a voluntary binge-like drinking model, such as "drinking-in-the-dark" (DID), has not been thoroughly explored. Additionally, studies assessing ethanol-elicited neuronal activation may or may not involve stereotaxic surgery, which could impact c-Fos IR. The experiments detailed herein aimed to assess the effects of voluntary binge-like ethanol consumption on c-Fos IR in brain regions implicated in ethanol intake in animals with and without surgery experience...
October 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/29101021/microglial-specific-transcriptome-changes-following-chronic-alcohol-consumption
#14
Gizelle M McCarthy, Sean P Farris, Yuri A Blednov, R Adron Harris, R Dayne Mayfield
Microglia are fundamentally important immune cells within the central nervous system (CNS) that respond to environmental challenges to maintain normal physiological processes. Alterations in steady-state cellular function and over-activation of microglia can facilitate the initiation and progression of neuropathological conditions such as Alzheimer's disease, Multiple Sclerosis, and Major Depressive Disorder. Alcohol consumption disrupts signaling pathways including both innate and adaptive immune responses that are necessary for CNS homeostasis...
October 31, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29097069/dose-related-ethanol-intake-cx43-and-nav1-5-remodeling-exploring-insights-of-altered-ventricular-conduction-and-qrs-fragmentation-in-excessive-alcohol-users
#15
Chung-Lieh Hung, Yu-Jun Lai, Po-Ching Chi, Liang-Chia Chen, Ya-Ming Tseng, Jen-Yuan Kuo, Cheng-I Lin, Yao-Chang Chen, Shing-Jong Lin, Hung-I Yeh
BACKGROUND: Chronic, excessive ethanol intake has been linked with various electrical instabilities, conduction disturbances, and even sudden cardiac death, but the underlying cause for the latter is insufficiently delineated. METHODS: We studied surface electrocardiography (ECG) in a community-dwelling cohort with moderate-to-heavy daily alcohol intake (grouped as >90g/day, ≤90g/day, and nonintake). RESULTS: Compared with nonintake, heavier alcohol users showed markedly widened QRS duration and higher prevalence of QRS fragmentation (64...
October 30, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29089335/the-effects-of-periconceptional-maternal-alcohol-intake-and-a-postnatal-high-fat-diet-on-obesity-and-liver-disease-in-male-and-female-rat-offspring
#16
Emelie M Gardebjer, James S M Cuffe, Leigh C Ward, Sarah Steane, Stephen T Anderson, Emily S Dorey, Jacinta I Kalisch-Smith, Marie Pantaleon, Suyinn Chong, Lisa Yamada, Mary E Wlodek, Helle Bielefeldt-Ohmann, Karen M Moritz
The effects of maternal alcohol consumption around the time of conception on offspring are largely unknown and difficult to determine in a human population. This study utilized a rodent model to examine if periconceptional alcohol (PC:EtOH), alone or in combination with a postnatal high-fat diet (HFD) resulted in obesity and liver dysfunction. Sprague-Dawley rats were fed a control or ethanol-containing liquid diet (12.5% EtOH v/v) from 4 days prior to mating until 4 days of gestation (n=12/group). A subset of offspring was fed a HFD between 3-8 months of age...
October 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29082267/intermittent-access-to-ethanol-induces-escalated-alcohol-consumption-in-primates
#17
S G Lindell, M L Schwandt, S J Suomi, K C Rice, M Heilig, C S Barr
BACKGROUND: Escalation of voluntary alcohol drinking is characteristic of alcohol addiction and can be induced in rodents using intermittent access to alcohol. This model has been used to evaluate candidate therapeutics, but key systems involved in the transition into alcohol addiction, such as CRF, differ in their organization between rodents and primates. We examined the ability of an intermittent access schedule to induce escalation of voluntary alcohol drinking in non-human primates and used this model to assess the role of corticotropin releasing hormone (CRF) signaling in this process...
April 2017: Journal of Addictive Behaviors, Therapy & Rehabilitation
https://www.readbyqxmd.com/read/29072170/caffeine-intake-and-abstract-reasoning-among-1374-unselected-men-and-women-from-general-population-role-of-the-163c-a-polymorphism-of-cyp1a2-gene
#18
Edoardo Casiglia, Valérie Tikhonoff, Federica Albertini, Jacopo Favaro, Martina Montagnana, Elisa Danese, Francesco Finatti, Marco Benati, Alberto Mazza, Lucia Dal Maso, Paolo Spinella, Paolo Palatini
BACKGROUND AND AIMS: The possible effect of caffeine as an enhancer of cognitive performance, particularly that on abstract reasoning, has never been studied in an epidemiological setting, especially in relation to -163C>A polymorphism of CYP1A2 gene, largely controlling caffeine metabolism. Aim of this study was to ascertain whether in general population free chronic caffeine intake modifies abstract reasoning, and if this effect is influenced by the above mentioned genotype, by age, schooling, ethanol intake and smoking habits...
August 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29066961/different-molecular-behavioral-endophenotypes-in-c57bl-6j-mice-predict-the-impact-of-ox1-receptor-blockade-on-binge-like-ethanol-intake
#19
Manuel Alcaraz-Iborra, Francisco Navarrete, Elisa Rodríguez-Ortega, Leticia de la Fuente, Jorge Manzanares, Inmaculada Cubero
Ethanol (EtOH) research has focused on stages of dependence. It is of paramount importance to more deeply understand the neurobehavioral factors promoting increased risk for EtOH binge drinking during the early stages of the addiction cycle. The first objective of this study was to evaluate whether C57BL/6J mice showing high drinking in the dark (DID) exhibit neurobehavioral traits known to contribute to EtOH binge-drinking disorders. Comparing high vs. low drinkers (HD/LD), we evaluated different types of basal anxiety-like responses, EtOH preference and sensitivity to the reinforcing properties of EtOH, and basal mRNA expression of the OX1/OX2 receptors (OX1r/OX2r) within the prefrontal cortex (PFC) and the nucleus accumbens (NAcc)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29063269/slow-metabolizing-adh1b-and-inactive-heterozygous-aldh2-increase-vulnerability-to-fatty-liver-in-japanese-men-with-alcohol-dependence
#20
Akira Yokoyama, Nobuhito Taniki, Sachiko Hara, Emiko Haysashi, Nobuhiro Nakamoto, Takeshi Mizukami, Katsuya Maruyama, Tetsuji Yokoyama
BACKGROUND: Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver. METHODS: We evaluated associations between the presence of fatty liver and ADH1B and ALDH2 genotypes and other factors in 1604 Japanese men who had been admitted for treatment of alcohol dependence...
October 23, 2017: Journal of Gastroenterology
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