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https://www.readbyqxmd.com/read/27901267/binge-alcohol-intake-after-hypergravity-stress-sustainably-decreases-ampk-and-transcription-factors-necessary-for-hepatocyte-survival
#1
Sang Gil Lee, Hong Min Wu, Chan Gyu Lee, Choong Sik Oh, So Won Chung, Sang Geon Kim
BACKGROUND: Binge alcohol consumption elicits mitochondrial dysfunction in hepatocytes. An understanding of the effect of ethanol (EtOH) exposure after hypergravity stress on liver function may assist in the implementation of pathophysiological countermeasures for aerospace missions. This study investigated whether a combination of hypergravity stress and binge alcohol intake has a detrimental effect on AMP-activated protein kinase (AMPK) and other molecules necessary for hepatocyte survival...
November 30, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27899216/poisoning-suicide-with-ingestion-of-the-pyrethroids-alpha-cypermethrin-and-deltamethrin-and-the-antidepressant-mirtazapine-a-case-report
#2
Vassiliki A Boumba, Georgios N Rallis, Theodore Vougiouklakis
This case report describes a death attributed to the intake of the pyrethroid insecticides, alpha-cypermethrin and deltamethrin, and the antidepressant mirtazapine. The autopsy findings showed absence of external traumatic injuries and internal generalized visceral congestion, edema and cyanosis. The toxicological results revealed the presence of a toxic concentration of mirtazapine (12.5mg/L and 10.7mg/L in blood and urine, respectively) and high concentrations of pyrethroids (2.46mg/L alpha-cypermethrin and 2...
November 22, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27894930/sex-dependent-influence-of-chronic-mild-stress-cms-on-voluntary-alcohol-consumption-study-of-neurobiological-consequences
#3
Eva M Marco, Javier Antonio Ballesta, Carlos Irala, María-Donina Hernández, María Elisa Serrano, Virginia Mela, Meritxell López-Gallardo, María-Paz Viveros
Alcohol use disorder and depression are highly comorbid, and both conditions exhibit important sexual dimorphisms. Here, we aimed to investigate voluntary alcohol consumption after 6weeks of chronic mild stress (CMS) in Wistar rats - employed as an animal model of depression. Male and female rats were investigated, and changes in several molecular markers were analysed in frontal cortex (FCx) and hippocampal formation (HF). CMS induced depressive-like responses in the forced swimming test - increased immobility time - in male and female animals, without affecting anhedonia (sucrose preference test) nor motor activity (holeboard); body weight gain and food intake were diminished only among CMS males...
November 25, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27889070/prenatal-ethanol-exposure-modifies-locomotor-activity-and-induces-selective-changes-in-met-enk-expression-in-adolescent-rats
#4
P Abate, A C Reyes-Guzmán, K Hernández-Fonseca, M Méndez
Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be understood. This work assessed the susceptibility of adolescent rats to prenatal and/or postnatal ethanol exposure in terms of behavioral responses, as well as alcohol effects on Met-enk expression in brain areas related to drug reinforcement...
November 22, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27888055/dietary-choline-levels-modify-the-effects-of-prenatal-alcohol-exposure-in-rats
#5
Nirelia M Idrus, Kristen R Breit, Jennifer D Thomas
Prenatal alcohol exposure can cause a range of physical and behavioral alterations; however, the outcome among children exposed to alcohol during pregnancy varies widely. Some of this variation may be due to nutritional factors. Indeed, higher rates of fetal alcohol spectrum disorders (FASD) are observed in countries where malnutrition is prevalent. Epidemiological studies have shown that many pregnant women throughout the world may not be consuming adequate levels of choline, an essential nutrient critical for brain development, and a methyl donor...
November 23, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27882208/maternal-separation-and-the-risk-of-drug-abuse-in-later-life
#6
REVIEW
Fatemeh Delavari, Vahid Sheibani, Saeed Esmaeili-Mahani, Nouzar Nakhaee
Maternal separation (MS) is defined as the termination of the continuity of mother-child relationship after the relationship is established. Although MS and maternal deprivation are different in terms of their definitions, these two terms are usually used interchangeably. This review aims to investigate the effect of MS on drug intake in adulthood. It has been proved that animal models are helpful in evaluating the effects of MS on drug intake risk in adulthood. There are relatively acceptable studies in this field on some drugs such as morphine, ethanol, and cocaine...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27859429/tigecycline-reduces-ethanol-intake-in-dependent-and-nondependent-male-and-female-c57bl-6j-mice
#7
Susan E Bergeson, Michelle A Nipper, Jeremiah Jensen, Melinda L Helms, Deborah A Finn
BACKGROUND: The chronic intermittent ethanol (CIE) paradigm is valuable for screening compounds for efficacy to reduce drinking traits related to alcohol use disorder (AUD), as it measures alcohol consumption and preference under physical dependence conditions. Air control-treated animals allow simultaneous testing of similarly treated, nondependent animals. As a consequence, we used CIE to test the hypothesis that tigecycline, a semisynthetic tetracycline similar to minocycline and doxycycline, would reduce alcohol consumption regardless of dependence status...
December 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27859416/effective-reduction-in-high-ethanol-drinking-by-semisynthetic-tetracycline-derivatives
#8
Peter J Syapin, Joseph M Martinez, David C Curtis, Patrick C Marquardt, Clayton L Allison, Jessica A Groot, Carol Baby, Yazan M Al-Hasan, Ismael Segura-Ulate, Matthew J Scheible, Katy T Nicholson, Jose Luis Redondo, David R M Trotter, David S Edwards, Susan E Bergeson
BACKGROUND: New pharmacotherapies to treat alcohol use disorders (AUD) are needed. Given the complex nature of AUD, there likely exist multiple novel drug targets. We, and others, have shown that the tetracycline drugs, minocycline and doxycycline, reduced ethanol (EtOH) drinking in mice. To test the hypothesis that suppression of high EtOH consumption is a general property of tetracyclines, we screened several derivatives for antidrinking activity using the Drinking-In-the-Dark (DID) paradigm...
December 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27827272/the-inhibitory-effect-of-meadowsweet-filipendula-ulmaria-on-radiation-induced-carcinogenesis-in-rats
#9
Vladimir G Bespalov, Valery A Alexandrov, Alexandr L Semenov, Elena G Kovan'ko, Sergey D Ivanov, Galina I Vysochina, Vera А Kostikova, Denis A Baranenko
PURPOSE: To examine the ability of the meadowsweet preparation to inhibit carcinogenesis induced by ionizing radiation in female rats. MATERIALS AND METHODS: The chemical composition of meadowsweet (Filipendula ulmaria) raw material (ethanol and aqueous extracts of meadowsweet flowers) has been studied for the presence of flavonoids, tannins and catechins. In animal experiments adult female LIO strain rats were subjected to a single whole body γ-irradiation at a dose of 4 Gy...
November 9, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27822501/inhibition-of-ikk%C3%AE-reduces-ethanol-consumption-in-c57bl-6j-mice
#10
Jay M Truitt, Yuri A Blednov, Jillian M Benavidez, Mendy Black, Olga Ponomareva, Jade Law, Morgan Merriman, Sami Horani, Kelly Jameson, Amy W Lasek, R Adron Harris, R Dayne Mayfield
Proinflammatory pathways in neuronal and non-neuronal cells are implicated in the acute and chronic effects of alcohol exposure in animal models and humans. The nuclear factor-κB (NF-κB) family of DNA transcription factors plays important roles in inflammatory diseases. The kinase IKKβ mediates the phosphorylation and subsequent proteasomal degradation of cytosolic protein inhibitors of NF-κB, leading to activation of NF-κB. The role of IKKβ as a potential regulator of excessive alcohol drinking had not previously been investigated...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27821289/evaluating-the-effects-of-refined-carbohydrate-and-fat-diets-with-acute-ethanol-consumption-using-a-mouse-model-of-alcoholic-liver-injury
#11
Juliana L Gonçalves, Norinne Lacerda-Queiroz, Josiane F L Sabino, Pedro E Marques, Izabela Galvão, Conrado O Gamba, Geovanni D Cassali, Luana M de Carvalho, Daniel Almeida da Silva E Silva, Adaliene Versiani, Mauro M Teixeira, Ana Maria Caetano de Faria, Angélica T Vieira, Ana Lúcia Brunialti-Godard
Alcoholism is a multifactorial and complex disorder responsible for 5.9% of deaths worldwide. Excessive consumption of ethanol (Et-OH) induces alcoholic liver disease (ALD), a condition comprising a spectrum of clinical signs and morphological changes, ranging from fatty liver (steatosis) to more severe forms of chronic liver injury. Secondary cofactors, such as nutritional and hepatotoxic comorbid conditions, can also contribute to liver disease development. Here we investigated the effects in the progression of ALD following short-term exposure to diet high in refined carbohydrates (HC), a high-sugar and -butter (HSB) hypercaloric diet and acute Et-OH consumption...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27816465/european-code-against-cancer-4th-edition-alcohol-drinking-and-cancer
#12
Chiara Scoccianti, Michele Cecchini, Annie S Anderson, Franco Berrino, Marie-Christine Boutron-Ruault, Carolina Espina, Timothy J Key, Michael Leitzmann, Teresa Norat, Hilary Powers, Martin Wiseman, Isabelle Romieu
Alcohol consumption is the third leading risk factor for disease and mortality in Europe. As evaluated by the International Agency for Research on Cancer (IARC) Monographs, a causal relationship is established for consumption of alcoholic beverages and cancers of the oral cavity, pharynx, larynx, oesophagus, liver, colorectum and female breast, even at low and moderate alcohol intakes. The higher the amount of alcohol consumed, the higher the risk of developing cancer. In Europe, an estimated 10% (95% CI: 7%-13%) of all cancer cases in men and 3% (95% CI: 1%-5%) of all cancer cases in women are attributable to alcohol consumption...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27815535/pattern-analysis-uncovers-a-chronic-ethanol-induced-disruption-of-the-switch-like-dynamics-of-c-ebp-%C3%AE-and-c-ebp-%C3%AE-genome-wide-binding-during-liver-regeneration
#13
Lakshmi Kuttippurathu, Biswanath Patra, Daniel Cook, Jan B Hoek, Rajanikanth Vadigepalli
Chronic ethanol intake impairs liver regeneration through a system-wide alteration in the regulatory networks driving the response to injury. Our study focused on the initial phase of response to 2/3(rd) partial hepatectomy (PHx) to investigate how adaptation to chronic ethanol intake affects the genome-wide binding profiles of the transcription factors C/EBP-β and C/EBP-α. These factors participate in complementary and often opposing functions for maintaining cellular differentiation, regulating metabolism, and governing cell growth during liver regeneration...
November 4, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27812679/acute-ethanol-intake-induces-nad-p-h-oxidase-activation-and-rhoa-translocation-in-resistance-arteries
#14
Janaina A Simplicio, Ulisses Vilela Hipólito, Gabriel Tavares do Vale, Glaucia Elena Callera, Camila André Pereira, Rhian M Touyz, Rita de Cássia Tostes, Carlos R Tirapelli
Background: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted. Objective: To investigate whether acute ethanol intake activates the vascular RhoA/Rho kinase pathway in resistance arteries and the role of NAD(P)H oxidase-derived reactive oxygen species (ROS) on such response. We also evaluated the requirement of p47phox translocation for ethanol-induced NAD(P)H oxidase activation...
October 27, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27806647/slow-release-l-cysteine-capsule-prevents-gastric-mucosa-exposure-to-carcinogenic-acetaldehyde-results-of-a-randomised-single-blinded-cross-over-study-of-helicobacter-associated-atrophic-gastritis
#15
Per M Hellström, Panu Hendolin, Pertti Kaihovaara, Leif Kronberg, Axel Meierjohann, Anders Millerhovf, Lea Paloheimo, Heidi Sundelin, Kari Syrjänen, Dominic-Luc Webb, Mikko Salaspuro
INTRODUCTION: Helicobacter-induced atrophic gastritis with a hypochlorhydric milieu is a risk factor for gastric cancer. Microbes colonising acid-free stomach oxidise ethanol to acetaldehyde, a recognised group 1 carcinogen. OBJECTIVE: To assess gastric production of acetaldehyde and its inert condensation product, non-toxic 2-methyl-1,3-thiazolidine-4-carboxylic acid (MTCA), after alcohol intake under treatment with slow-release L-cysteine or placebo. METHODS: Seven patients with biopsy-confirmed atrophic gastritis, low serum pepsinogen and high gastrin-17 were studied in a cross-over single-blinded design...
November 3, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27799068/recurrent-purpura-due-to-alcohol-related-schamberg-s-disease-and-its-association-with-serum-immunoglobulins-a-longitudinal-observation-of-a-heavy-drinker
#16
Udo Bonnet, Claudia Selle, Katrin Isbruch, Katrin Isbruch
BACKGROUND: It is unusual for purpura to emerge as a result of drinking alcohol. Such a peculiarity was observed in a 55-year-old man with a 30-year history of heavy alcohol use. CASE PRESENTATION: The Caucasian patient was studied for 11 years during several detoxification treatments. During the last 2 years of that period, purpuric rashes were newly observed. The asymptomatic purpura was limited to both lower limbs, self-limiting with abstinence, and reoccurring swiftly with alcohol relapse...
October 31, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27793734/reversal-of-ethanol-induced-hepatotoxicity-by-cinnamic-and-syringic-acids-in-mice
#17
Sheng-Lei Yan, Zhi-Hong Wang, Hsiu-Fang Yen, Yi-Ju Lee, Mei-Chin Yin
Ethanol was used to induce acute hepatotoxicity in mice. Effects of cinnamic acid (CA) and syringic acid (SA) post-intake for hepatic recovery from alcoholic injury was investigated. Ethanol treated mice were supplied by CA or SA at 40 or 80 mg/kg BW/day for 5 days. Results showed that ethanol stimulated protein expression of CYP2E1, p47(phox), gp91(phox), cyclooxygenase-2 and nuclear factor kappa B in liver. CA or SA post-intake restricted hepatic expression of these molecules. Ethanol suppressed nuclear factor erythroid 2-related factor (Nrf2) expression, and CA or SA enhanced Nrf2 expression in cytosolic and nuclear fractions...
October 25, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27793543/variable-effects-of-chronic-intermittent-ethanol-exposure-on-ethanol-drinking-in-a-genetically-diverse-mouse-cohort
#18
Marcelo F Lopez, Michael F Miles, Robert W Williams, Howard C Becker
The BXD family of mice were generated by crossing and inbreeding ethanol-preferring C57BL/6J and ethanol-avoiding DBA/2J strains that differ greatly in genome sequence and other behaviors. This study evaluated variations in the level of voluntary ethanol intake in a cohort of 42 BXD strains and both progenitor strains using a model of alcohol dependence and relapse drinking. A total of 119 BXDs (85 males, 34 females) (n ∼ 4 per genotype; 1/genotype/sex/group) were evaluated along with males from both progenitor strains (n = 14-15/genotype)...
October 13, 2016: Alcohol
https://www.readbyqxmd.com/read/27790100/post-weaning-environmental-enrichment-but-not-chronic-maternal-isolation-enhanced-ethanol-intake-during-periadolescence-and-early-adulthood
#19
Luciana R Berardo, María C Fabio, Ricardo M Pautassi
This study analyzed ethanol intake in male and female Wistar rats exposed to maternal separation (MS) during infancy (postnatal days 1-21, PD1-21) and environmental enrichment (EE) during adolescence (PD 21-42). Previous work revealed that MS enhances ethanol consumption during adulthood. It is still unknown if a similar effect is found during adolescence. Several studies, in turn, have revealed that EE reverses stress experiences, and reduces ethanol consumption and reinforcement; although others reported greater ethanol intake after EE...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27788775/alpha-ketoglutarate-reduces-ethanol-toxicity-in-drosophila-melanogaster-by-enhancing-alcohol-dehydrogenase-activity-and-antioxidant-capacity
#20
Maria M Bayliak, Halyna V Shmihel, Maria P Lylyk, Kenneth B Storey, Volodymyr I Lushchak
Ethanol at low concentrations (<4%) can serve as a food source for fruit fly Drosophila melanogaster, whereas at higher concentrations it may be toxic. In this work, protective effects of dietary alpha-ketoglutarate (AKG) against ethanol toxicity were studied. Food supplementation with 10-mM AKG alleviated toxic effects of 8% ethanol added to food, and improved fly development. Two-day-old adult flies, reared on diet containing both AKG and ethanol, possessed higher alcohol dehydrogenase (ADH) activity as compared with those reared on control diet or diet with ethanol only...
September 2016: Alcohol
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