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https://www.readbyqxmd.com/read/28344411/effect-of-ethanolic-extract-of-propolis-as-an-alternative-to-antibiotics-as-a-growth-promoter-on-broiler-performance-serum-biochemistry-and-immune-responses
#1
Abbasali Gheisari, Shekofa Shahrvand, Nasir Landy
AIM: An in vivo experiment was conducted to investigate the effect of different levels of ethanolic extract of propolis, on growth performance, carcass traits, serum biochemistry, and humoral immune responses of chickens, as compared with the antibiotic flavophospholipol. MATERIALS AND METHODS: 312 1-day-old as-hatched broiler chicks (Ross 308) were randomly allotted to 6 treatments with 4 replicate pens per treatment. The 6 dietary treatments fed for 42 days consisted of a corn-soybean meal basal diet (control); control plus 4...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28344087/subacute-alcohol-and-or-disulfiram-intake-affects-bioelements-and-redox-status-in-rat-testes
#2
Ana Djuric, Aida Begic, Borko Gobeljic, Ana Pantelic, Goran Zebic, Ivana Stevanovic, Dragan Djurdjevic, Milica Ninkovic, Vera Prokic, Ivan Stanojevic, Danilo Vojvodic, Mirjana Djukic
The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatment (21 and/or 42 days): C21/C42 groups (controls); OL21/OL42 groups (0.5 mL olive oil intake); A1-21 groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day); and A21+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol)...
March 23, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28336571/regulation-of-alcohol-extinction-and-cue-induced-reinstatement-by-specific-projections-between-medial-prefrontal-cortex-nucleus-accumbens-and-basolateral-amygdala
#3
Colby R Keistler, Emma Hammarlund, Jacqueline M Barker, Colin W Bond, Ralph J DiLeone, Christopher Pittenger, Jane R Taylor
The ability to inhibit drinking is a significant challenge for recovering alcoholics, especially in the presence of alcohol-associated cues. Previous studies have demonstrated that the regulation of cue-guided alcohol seeking is mediated by the basolateral amygdala (BLA), nucleus accumbens (NAc), and medial prefrontal cortex (mPFC). However, given the high interconnectivity between these structures, it is unclear how mPFC projections to each subcortical structure, as well as projections between BLA and NAc, mediate alcohol-seeking behaviors...
March 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28326002/anti-obesity-effect-of-solidago-virgaurea-var-gigantea-extract-through-regulation-of-adipogenesis-and-lipogenesis-pathways-in-high-fat-diet-induced-obese-mice-c57bl-6n
#4
Zhiqiang Wang, Ju Hee Kim, Young Soo Jang, Chea Ha Kim, Jae-Yong Lee, Soon Sung Lim
Background: Obesity is associated with an increase in adipogenesis and is becoming a serious health problem in modern society. Objective: The effects of various Solidago virgaurea var. gigantean (SV) ethanolic aqueous extracts on anti-adipogenesis in 3T3-L1 cells were investigated. In addition, the effect of SV 10% ethanolic extract (SV10E) on preventing obesity was studied in high-fat diet-induced obese mice (C57BL/6 N). Design: The effect of SV10E on preventing obesity was studied in mice (n = 6): normal-fat diet, high-fat diet (HFD), HFD supplemented with 1% (10 g/kg) Garcinia cambogia extract of 60% (-)-hydroxycitric acid (positive control), HFD supplemented with 0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28324816/sex-differences-and-hormonal-modulation-of-ethanol-enhanced-risk-taking-in-rats
#5
Kathryn G Wallin-Miller, Jordyn Chesley, Juliana Castrillon, Ruth I Wood
BACKGROUND: Ethanol (EtOH) intake correlates with increased risk-taking, and sex differences exist in both EtOH use and risk-taking in humans and rats. However, the interaction of sex and gonadal hormones to affect risk-taking under the influence of EtOH has not been determined. This was the focus of the current study. METHODS: Adult Long-Evans rats (n=18 males and females) were gonadectomized and received hormone replacement at physiologic levels or blank implants (n=7-9/group)...
March 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28322978/delta-opioid-receptor-antagonism-leads-to-excessive-ethanol-consumption-in-mice-with-enhanced-activity-of-the-endogenous-opioid-system
#6
Piotr Poznanski, Anna Lesniak, Michal Korostynski, Klaudia Szklarczyk, Marzena Lazarczyk, Piotr Religa, Magdalena Bujalska-Zadrozny, Bogdan Sadowski, Mariusz Sacharczuk
The opioid system modulates the central reinforcing effects of ethanol and participates in the etiology of addiction. However, the pharmacotherapy of ethanol dependence targeted on the opioid system is little effective and varies due to individual patients' sensitivity. In the present study, we used two mouse lines with high (HA) and low (LA) activity of the endogenous opioid system to analyze the effect of opioid receptor blockade on ethanol drinking behavior. We found that LA and HA lines characterized by divergent magnitudes of swim stress-induced analgesia also differ in ethanol intake and preference...
March 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28322866/decreased-anxiety-voluntary-ethanol-intake-and-ethanol-induced-cpp-acquisition-following-activation-of-the-metabotropic-glutamate-receptor-8-mglur8
#7
Amine Bahi
Metabotropic glutamate receptors (mGluRs) are important modulators of excitatory neurotransmission, and have been implicated in addiction to alcohol and anxiety-related behaviors. However, the behavioral consequence and contribution of individual subtypes are not known yet. This study determined the effects of mGluR8 activation on anxiety-like behavior, voluntary ethanol intake and ethanol-induced conditioned reward. To this aim, anxiety and spontaneous behavior were measured in C57BL/6J mice using the elevated plus maze (EPM), open field (OF) and light-dark box (LDB) tests after systemic injection of the selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine ((S)-3,4-DCPG)...
March 17, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28322841/electrophysiological-properties-and-augmented-catecholamine-release-from-chromaffin-cells-of-wky-and-shr-rats-contributing-to-the-hypertension-development-elicited-by-chronic-etoh-consumption
#8
Guilherme Henrique Souza Bomfim, Iago Méndez-López, José Carlos Fernández-Morales, Juan Fernando Padín, Aron Jurkiewicz, Neide Hyppolito Jurkiewicz, Antonio García García
It is known that chronic ethanol (EtOH) consumption leads to hypertension development and has been associated with deleterious effects on the cardiovascular system. Whether this condition alters calcium (Ca(2+)) signaling and exocytosis in adrenal chromaffin cells (CCs) as the case is for genetic hypertension, is unknown. We explored this question in four randomized experimental groups, male Wistar Kyoto (WKY/EtOH) and Spontaneously Hypertensive (SHR/EtOH) rats were subjected to the intake of increasing EtOH concentrations (5-20%, for 30 days) and their respective controls (WKY/Control and SHR/Control) received water...
March 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28303373/viral-mediated-overexpression-of-the-myelin-transcription-factor-1-myt1-in-the-dentate-gyrus-attenuates-anxiety-and-ethanol-related-behaviors-in-rats
#9
Amine Bahi, Jean-Luc Dreyer
RATIONALE: Myelin Transcription Factor 1 (MyT1), a member of the Zinc Finger gene family, plays a fundamental role in the nervous system. Recent research has suggested that this transcription factor is associated with the pathophysiology of psychiatric disorders including addiction, schizophrenia, and depression. However, the role of MyT1 in anxiety- and ethanol-related behaviors is still unknown. OBJECTIVES: We evaluated the effects of lentiviral-mediated overexpression of MyT1 in the dentate gyrus (DG) on anxiety- and ethanol-related behaviors in rats...
March 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28295675/improved-detection-of-alcohol-consumption-using-the-novel-marker-phosphatidylethanol-in-the-transplant-setting-results-of-a-prospective-study
#10
Hilke Andresen-Streichert, Yannick Beres, Wolfgang Weinmann, Alexandra Schröck, Alexander Müller, Gisela Skopp, Sven Pischke, Eik Vettorazzi, Ansgar Lohse, Björn Nashan, Martina Sterneck
MAIN PROBLEM: Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. METHODS: In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate deficient transferrin (CDT), ethylglucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. RESULTS: 28 (25%) patients tested positive for at least one alcohol marker...
March 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28293172/ethanol-modulates-the-spontaneous-complex-spike-waveform-of-cerebellar-purkinje-cells-recorded-in-vivo-in-mice
#11
Guang-Jian Zhang, Mao-Cheng Wu, Jin-Di Shi, Yin-Hua Xu, Chun-Ping Chu, Song-Biao Cui, De-Lai Qiu
Cerebellar Purkinje cells (PCs) are sensitive to ethanol, but the effect of ethanol on spontaneous complex spike (CS) activity in these cells in vivo is currently unknown. Here, we investigated the effect of ethanol on spontaneous CS activity in PCs in urethane-anesthetized mice using in vivo patch-clamp recordings and pharmacological manipulation. Ethanol (300 mM) induced a decrease in the CS-evoked pause in simple spike (SS) firing and in the amplitude of the afterhyperpolarization (AHP) under current clamp conditions...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28291298/-neurobiology-of-alcohol-dependence-and-implications-on-treatment
#12
Ertuğrul Eşel, Köksal Dinç
The process of alcohol dependence has been conceptualized as a progress from controlled alcohol intake to compulsive alcohol consumption or a shift from alcohol intake for pleasure to compulsory alcohol seeking behavior. Hereditary and physical factors and the interaction of individuals with their environment, as well as permanent changes in the neurotransmitter and neurohormonal systems in the brain due to alcohol use, play the most important role in the etiology of alcohol dependence. The effects of ethanol on the neurotransmitter, neuropeptide and neuroendocrine systems not only account for its acute physiological and euphoric/reinforcing effects but also seem to be responsible for the development of dependence...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28288338/ghb-involved-crimes-among-intoxicated-patients
#13
Máté Kapitány-Fövény, Gábor Zacher, János Posta, Zsolt Demetrovics
INTRODUCTION: In recent years, the involvement of GHB in drug facilitated sexual assaults has been one of the most frequently studied aspects of GHB in both clinical and non-clinical settings. GHB-involved acquisitory crimes, however, can be mentioned as understudied research topics, as well as the poisoning severity properties of GHB. MEASURES: The medical reports of Péterfy Sándor Street Hospital Clinic and Casualty Centre's 408 GHB-intoxication cases (352 patients) were reviewed and registered...
March 10, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28284858/inhibition-of-potassium-currents-is-involved-in-antiarrhythmic-effect-of-moderate-ethanol-on-atrial-fibrillation
#14
Baode Yang, Chenxing Li, Junyi Sun, Xinghui Wang, Xinling Liu, Chun Yang, Lina Chen, Jun Zhou, Hao Hu
Excessive consumption of alcohol is a well-established risk factor of atrial fibrillation (AF). However, the effects of moderate alcohol drinking remain to be elucidated. This study was designed to determine the effects of moderate ethanol ingestion on atrial fibrillation and the electrophysiological mechanisms. In acetylcholine-induced canine and mouse AF models, the moderate ethanol prevented the generation and persistence of AF through prolonging the latent period of AF and shortening the duration of AF...
March 9, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28276137/binge-drinking-and-the-risk-of-liver-events-a-population-based-cohort-study
#15
Fredrik Åberg, Jaana Helenius-Hietala, Pauli Puukka, Antti Jula
BACKGROUND & AIMS: Binge drinking or heavy episodic drinking is increasingly prevalent, but the health effects are incompletely understood. We investigated whether binge drinking increases the risk for liver disease above the risk due to average alcohol consumption. METHODS: 6366 subjects without baseline liver disease who participated in the Finnish population-based Health 2000 Study (2000-2001), a nationally representative cohort. Follow-up data from national registers until 2013 were analysed for liver-related admissions, mortality, and liver cancer...
March 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28275340/a-rat-drinking-in-the-dark-model-for-studying-ethanol-and-sucrose-consumption
#16
Joan Y Holgate, Masroor Shariff, Erica W H Mu, Selena Bartlett
Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is suitable for rats or if one rat model is more advantageous than another for studying binge-like consumption. Methods: Male Wistar rats consumed 20% ethanol or 5% sucrose using IA2BC or DID for 12 weeks...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28275339/nicotine-increases-alcohol-intake-in-adolescent-male-rats
#17
Armando Lárraga, James D Belluzzi, Frances M Leslie
Background: Use of alcohol and tobacco, the two most concurrently abused drugs, typically first occurs during adolescence. Yet, there have been no systematic analyses of ethanol (EtOH) and nicotine (Nic) interactions during adolescence. Recent animal studies report that kappa-opioid (KOR) receptor activation mediates age differences in drug reinforcement. Our hypothesis is that concurrent self-administration of EtOH and Nic will be greater in adolescent rats because of age differences in KOR function. Furthermore, exposure to alcohol and nicotine during adolescence has been reported to increase EtOH intake in adulthood...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28274821/the-galanin-3-receptor-antagonist-snap-37889-suppresses-alcohol-drinking-and-morphine-self-administration-in-mice
#18
Karlene J Scheller, Spencer J Williams, Andrew J Lawrence, Elvan Djouma
The neuropeptide, galanin, is widely expressed in the central and peripheral nervous systems and is involved in a range of different functions including nociception, neurogenesis, hormone release, reproduction, cognitive function and appetite. Given the overlap between galanin expression and reward circuitry in the brain, galanin has been targeted for alcohol use disorder (AUD) and opioid dependency. Furthermore, the galanin-3 receptor (GAL3) specifically regulates emotional states and plays a role in motivation, reward and drug-seeking behaviour...
March 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28260515/toxicological-evaluation-in-silico-and-in-vivo-of-secondary-metabolites-of-cissampelos-sympodialis-in-rattus-norvegicus
#19
Luciana Scotti
Cissampelos sympodialis is a plant to northeastern Brazil region used by populace for treating diseases respiratory. Several studies have shown that the ethanol extract of the leaves have immunomodulatory and anti-inflammatory activities. The infusion is an ancient popular technique widely used in traditional medicine using as extracting means just hot water. This study aims to investigate the acute toxicological potential administering a dose of 2000mg/kg in Rattus norvegicus combined with in silico study of 117 alkaloids present in Cissampelos genre...
March 1, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28259708/oral-aversion-to-dietary-sugar-ethanol-and-glycerol-correlates-with-alterations-in-specific-hepatic-metabolites-in-a-mouse-model-of-human-citrin-deficiency
#20
Takeyori Saheki, Kanako Inoue, Hiromi Ono, Yuki Fujimoto, Sumie Furuie, Ken-Ichi Yamamura, Eishi Kuroda, Miharu Ushikai, Akihiro Asakawa, Akio Inui, Kazuhiro Eto, Takashi Kadowaki, Mitsuaki Moriyama, David S Sinasac, Takashi Yamamoto, Tatsuhiko Furukawa, Keiko Kobayashi
Mice carrying simultaneous homozygous mutations in the genes encoding citrin, the mitochondrial aspartate-glutamate carrier 2 (AGC2) protein, and mitochondrial glycerol-3-phosphate dehydrogenase (mGPD), are a phenotypically representative model of human citrin (a.k.a., AGC2) deficiency. In this study, we investigated the voluntary oral intake and preference for sucrose, glycerol or ethanol solutions by wild-type, citrin (Ctrn)-knockout (KO), mGPD-KO, and Ctrn/mGPD double-KO mice; all substances that are known or suspected precipitating factors in the pathogenesis of human citrin deficiency...
February 14, 2017: Molecular Genetics and Metabolism
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