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Ethanol intake

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https://www.readbyqxmd.com/read/28432009/the-lateral-hypothalamus-to-lateral-habenula-projection-but-not-the-ventral-pallidum-to-lateral-habenula-projection-regulates-voluntary-ethanol-consumption
#1
Chandni Sheth, Teri M Furlong, Kristen A Keefe, Sharif A Taha
The lateral habenula (LHb) is an epithalamic brain region implicated in aversive processing via negative modulation of midbrain dopamine (DA) and serotonin (5-HT) systems. Given the role of the LHb in inhibiting DA and 5-HT systems, it is thought to be involved in various psychiatric pathologies, including drug addiction. In support, it has been shown that LHb plays a critical role in cocaine- and ethanol-related behaviors, most likely by mediating drug-induced aversive conditioning. In our previous work, we showed that LHb lesions increased voluntary ethanol consumption and operant ethanol self-administration and blocked yohimbine-induced reinstatement of ethanol self-administration...
April 18, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28426670/mice-expressing-a-hyper-sensitive-form-of-the-cb1-cannabinoid-receptor-cb1-show-modestly-enhanced-alcohol-preference-and-consumption
#2
David J Marcus, Angela N Henderson-Redmond, Maciej Gonek, Michael L Zee, Jill C Farnsworth, Randa A Amin, Mary-Jeanette Andrews, Brian J Davis, Ken Mackie, Daniel J Morgan
We recently characterized S426A/S430A mutant mice expressing a desensitization-resistant form of the CB1 receptor. These mice display an enhanced response to endocannabinoids and ∆9-THC. In this study, S426A/S430A mutants were used as a novel model to test whether ethanol consumption, morphine dependence, and reward for these drugs are potentiated in mice with a "hyper-sensitive" form of CB1. Using an unlimited-access, two-bottle choice, voluntary drinking paradigm, S426A/S430A mutants exhibit modestly increased intake and preference for low (6%) but not higher concentrations of ethanol...
2017: PloS One
https://www.readbyqxmd.com/read/28421656/oral-intake-of-boesenbergia-pandurata-extract-improves-skin-hydration-gloss-and-wrinkling-a-randomized-double-blind-and-placebo-controlled-study
#3
Do Un Kim, Hee Chul Chung, Changhee Kim, Jae-Kwan Hwang
BACKGROUND: Photoaging is a severe skin damage that occurs as a result of exposure to external elements, primarily ultraviolet (UV) irradiation. Chronically, UV-irradiated skin exhibits the signs of sunburn and hyperpigmentation with the destruction of connective tissues. Previously, Boesenbergia pandurata (B. pandurata) and its active compound panduratin A showed antiphotoaging activities in vitro and in vivo. OBJECTIVE: The aim of this study was to investigate the clinical efficacy of B...
April 18, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28420969/acquisition-maintenance-and-relapse-like-alcohol-drinking-lessons-from-the-uchb-rat-line
#4
REVIEW
Yedy Israel, Eduardo Karahanian, Fernando Ezquer, Paola Morales, Marcelo Ezquer, Mario Rivera-Meza, Mario Herrera-Marschitz, María E Quintanilla
This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like drinking behavior in animals bred for their high-ethanol intake. Data from several rat strains/lines strongly suggest that catalase-mediated brain oxidation of ethanol into acetaldehyde is an absolute requirement (up 80%-95%) for rats to display ethanol's reinforcing effects and to initiate chronic ethanol intake. Acetaldehyde binds non-enzymatically to dopamine forming salsolinol, a compound that is self-administered...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28417982/total-and-beverage-specific-alcohol-intake-and-the-risk-of-aggressive-prostate-cancer-a-case-control-study
#5
N P Papa, R J MacInnis, H Jayasekara, D R English, D Bolton, I D Davis, N Lawrentschuk, J L Millar, J Pedersen, G Severi, M C Southey, J L Hopper, G G Giles
BACKGROUND: Ethanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent. METHODS: Using a case-control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28408342/chronic-ethanol-intake-induces-partial-microglial-activation-that-is-not-reversed-by-long-term-ethanol-withdrawal-in-the-rat-hippocampal-formation
#6
Catarina Cruz, Manuela Meireles, Susana M Silva
Neuroinflammation has been implicated in the pathogenesis of several disorders. Activation of microglia leads to the release of pro-inflammatory mediators and microglial-mediated neuroinflammation has been proposed as one of the alcohol-induced neuropathological mechanisms. The present study aimed to examine the effect of chronic ethanol exposure and long-term withdrawal on microglial activation and neuroinflammation in the hippocampal formation. Male rats were submitted to 6 months of ethanol treatment followed by a 2-month withdrawal period...
April 10, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28407090/foods-and-beverages-and-colorectal-cancer-risk-a-systematic-review-and-meta-analysis-of-cohort-studies-an-update-of-the-evidence-of-the-wcrf-aicr-continuous-update-project
#7
A R Vieira, L Abar, Dsm Chan, S Vingeliene, E Polemiti, C Stevens, D Greenwood, T Norat
Objective: As part of the World Cancer Research Fund International Continuous Update Project, we updated the systematic review and meta-analysis of prospective studies to quantify the dose-response between foods and beverages intake and colorectal cancer risk. Data Sources: PubMed and several databases up to May 31 st 2015. Study selection: Prospective studies reporting adjusted relative risk estimates for the association of specific food groups and beverages and risk of colorectal, colon and rectal cancer...
April 12, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28403148/human-neutrophil-peptide-1-promotes-alcohol-induced-hepatic-fibrosis-and-hepatocyte-apoptosis
#8
Rie Ibusuki, Hirofumi Uto, Kohei Oda, Akihiko Ohshige, Kazuaki Tabu, Seiichi Mawatari, Kotaro Kumagai, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirohito Tsubouchi, Akio Ido
BACKGROUND AND AIMS: Neutrophil infiltration of the liver is a typical feature of alcoholic liver injury. Human neutrophil peptide (HNP)-1 is an antimicrobial peptide secreted by neutrophils. The aim of this study was to determine if HNP-1 affects ethanol-induced liver injury and to examine the mechanism of liver injury induced by HNP-1. METHODS: Transgenic (TG) mice expressing HNP-1 under the control of a β-actin-based promoter were established. Ethanol was orally administered to HNP-1 TG or wild-type C57BL/6N (WT) mice...
2017: PloS One
https://www.readbyqxmd.com/read/28401284/targeting-the-subthalamic-nucleus-in-a-preclinical-model-of-alcohol-use-disorder
#9
Yann Pelloux, Christelle Baunez
BACKGROUND: The subthalamic nucleus (STN) has only recently been considered to have a role in reward processing. In rats, inactivation of the STN by lesion or high-frequency stimulation (HFS) decreases motivation for cocaine but increases motivation for sucrose. For ethanol, the effect of STN lesion depends on the individual's baseline intake; decreasing motivation for ethanol in rats with lower ethanol intake, while increasing motivation for ethanol in rats with higher-but still limited-ethanol intake...
April 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28398226/melatonin-reduces-angiogenesis-in-serous-papillary-ovarian-carcinoma-of-ethanol-preferring-rats
#10
Yohan Ricci Zonta, Marcelo Martinez, Isabel Cristina C Camargo, Raquel F Domeniconi, Luiz Antonio Lupi Júnior, Patricia Fernanda F Pinheiro, Russel J Reiter, Francisco Eduardo Martinez, Luiz Gustavo A Chuffa
Angiogenesis is a hallmark of ovarian cancer (OC); the ingrowth of blood vessels promotes rapid cell growth and the associated metastasis. Melatonin is a well-characterized indoleamine that possesses important anti-angiogenic properties in a set of aggressive solid tumors. Herein, we evaluated the role of melatonin therapy on the angiogenic signaling pathway in OC of an ethanol-preferring rat model that mimics the same pathophysiological conditions occurring in women. OC was chemically induced with a single injection of 7,12-dimethylbenz(a)anthracene (DMBA) under the ovarian bursa...
April 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28398003/midkine-in-the-mouse-ventral-tegmental-area-limits-ethanol-intake-and-ccl2-gene-expression
#11
Hu Chen, Donghong He, Amy W Lasek
Midkine (MDK) is a cytokine and neurotrophic factor that is more highly expressed in the brains of human alcoholics and in mice predisposed to drink large amounts of ethanol, suggesting that MDK may regulate ethanol consumption. Here we measured ethanol consumption in male and female Mdk knockout (-/-) mice using the two-bottle choice and the drinking in the dark (DID) tests. We found that Mdk -/- mice consumed significantly more ethanol than wild type controls in both tests. To determine if MDK acts in the ventral tegmental area (VTA) to regulate ethanol consumption, we delivered lentivirus expressing a Mdk shRNA into the VTA of male C57BL/6J mice to locally knockdown Mdk and performed the DID test...
April 11, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28390969/environmental-enrichment-reduces-chronic-psychosocial-stress-induced-anxiety-and-ethanol-related-behaviors-in-mice
#12
Amine Bahi
Previous research from our laboratory has shown that exposure to chronic psychosocial stress increased voluntary ethanol consumption and preference as well as acquisition of ethanol-induced conditioned place preference (CPP) in mice. This study was done to determine whether an enriched environment could have "curative" effects on chronic psychosocial stress-induced ethanol intake and CPP. For this purpose, experimental mice "intruders" were exposed to the chronic subordinate colony (CSC) housing for 19 consecutive days in the presence of an aggressive "resident" mouse...
April 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28382659/increased-firing-of-lateral-habenula-neurons-mediates-ethanol-aversion-potential-implications-for-substance-use-disorders
#13
Gabor Egervari, Tanni Rahman
Alcohol use disorder (AUD) is characterized by craving, loss of control over intake and continued use despite negative consequences. This article is protected by copyright. All rights reserved.
April 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28381286/no-evidence-of-a-role-of-the-%C3%AE-4-subunit-of-the-nicotinic-acetylcholine-receptor-in-alcohol-related-behaviors
#14
Helen M Kamens, Constanza Silva, Riley McCarthy, Ryan J Cox, Marissa A Ehringer
BACKGROUND: Nicotinic acetylcholine receptors have gained attention in the last several years as mediators of alcohol-related behaviors. The genes that code for the α5, α3, and β4 subunits (Chrna5, Chrna3, and Chrnb4, respectively) map adjacent to each other on human chromosome 15/mouse chromosome 9. Genetic variants in this region have been associated with alcohol phenotypes and mice that overexpress these three subunits have reduced ethanol intake. In the present experiments, we examined the role of the Chrnb4 gene in three ethanol behaviors: consumption, ataxia, and sedation...
April 5, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28355092/acute-toxicity-and-cytotoxicity-of-pereskia-aculeata-a-highly-nutritious-cactaceae-plant
#15
Debora O Silva, Mauricio Seifert, Fabiana R Nora, Vera L Bobrowski, Rogerio A Freitag, Heidi R Kucera, Leonardo Nora, Nilesh W Gaikwad
Pereskia aculeata is a Cactaceae plant with valuable nutritional properties, including terrific amounts of protein, minerals, vitamins, and fiber. However, P. aculeata is reported to contain antinutrients and alkaloids in its leaves. In addition, in a study on growth and development, Wistar rats fed with P. aculeata and casein as protein source grew less than the control group (fed with casein only). Therefore, in this study, we evaluated, for the first time, the oral acute toxicity of P. aculeata in rats and also the cytotoxicity behavior of the plant on lettuce seeds...
April 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28344411/effect-of-ethanolic-extract-of-propolis-as-an-alternative-to-antibiotics-as-a-growth-promoter-on-broiler-performance-serum-biochemistry-and-immune-responses
#16
Abbasali Gheisari, Shekofa Shahrvand, Nasir Landy
AIM: An in vivo experiment was conducted to investigate the effect of different levels of ethanolic extract of propolis, on growth performance, carcass traits, serum biochemistry, and humoral immune responses of chickens, as compared with the antibiotic flavophospholipol. MATERIALS AND METHODS: 312 1-day-old as-hatched broiler chicks (Ross 308) were randomly allotted to 6 treatments with 4 replicate pens per treatment. The 6 dietary treatments fed for 42 days consisted of a corn-soybean meal basal diet (control); control plus 4...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28344087/subacute-alcohol-and-or-disulfiram-intake-affects-bioelements-and-redox-status-in-rat-testes
#17
Ana Djuric, Aida Begic, Borko Gobeljic, Ana Pantelic, Goran Zebic, Ivana Stevanovic, Dragan Djurdjevic, Milica Ninkovic, Vera Prokic, Ivan Stanojevic, Danilo Vojvodic, Mirjana Djukic
The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C21/C42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A1-21 groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A21+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol)...
March 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28336571/regulation-of-alcohol-extinction-and-cue-induced-reinstatement-by-specific-projections-between-medial-prefrontal-cortex-nucleus-accumbens-and-basolateral-amygdala
#18
Colby R Keistler, Emma Hammarlund, Jacqueline M Barker, Colin W Bond, Ralph J DiLeone, Christopher Pittenger, Jane R Taylor
The ability to inhibit drinking is a significant challenge for recovering alcoholics, especially in the presence of alcohol-associated cues. Previous studies have demonstrated that the regulation of cue-guided alcohol seeking is mediated by the basolateral amygdala (BLA), nucleus accumbens (NAc), and medial prefrontal cortex (mPFC). However, given the high interconnectivity between these structures, it is unclear how mPFC projections to each subcortical structure, as well as projections between BLA and NAc, mediate alcohol-seeking behaviors...
March 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28326002/anti-obesity-effect-of-solidago-virgaurea-var-gigantea-extract-through-regulation-of-adipogenesis-and-lipogenesis-pathways-in-high-fat-diet-induced-obese-mice-c57bl-6n
#19
Zhiqiang Wang, Ju Hee Kim, Young Soo Jang, Chea Ha Kim, Jae-Yong Lee, Soon Sung Lim
Background: Obesity is associated with an increase in adipogenesis and is becoming a serious health problem in modern society. Objective: The effects of various Solidago virgaurea var. gigantean (SV) ethanolic aqueous extracts on anti-adipogenesis in 3T3-L1 cells were investigated. In addition, the effect of SV 10% ethanolic extract (SV10E) on preventing obesity was studied in high-fat diet-induced obese mice (C57BL/6 N). Design: The effect of SV10E on preventing obesity was studied in mice (n = 6): normal-fat diet, high-fat diet (HFD), HFD supplemented with 1% (10 g/kg) Garcinia cambogia extract of 60% (-)-hydroxycitric acid (positive control), HFD supplemented with 0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28324816/sex-differences-and-hormonal-modulation-of-ethanol-enhanced-risk-taking-in-rats
#20
Kathryn G Wallin-Miller, Jordyn Chesley, Juliana Castrillon, Ruth I Wood
BACKGROUND: Ethanol (EtOH) intake correlates with increased risk-taking, and sex differences exist in both EtOH use and risk-taking in humans and rats. However, the interaction of sex and gonadal hormones to affect risk-taking under the influence of EtOH has not been determined. This was the focus of the current study. METHODS: Adult Long-Evans rats (n=18 males and females) were gonadectomized and received hormone replacement at physiologic levels or blank implants (n=7-9/group)...
May 1, 2017: Drug and Alcohol Dependence
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