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Cu Zn superoxide dismutase

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https://www.readbyqxmd.com/read/28205575/cu-ii-atsm-improves-the-neurological-phenotype-and-survival-of-sod1-g93a-mice-and-selectively-increases-enzymatically-active-sod1-in-the-spinal-cord
#1
James B Hilton, Stephen W Mercer, Nastasia K H Lim, Noel G Faux, Gojko Buncic, Joseph S Beckman, Blaine R Roberts, Paul S Donnelly, Anthony R White, Peter J Crouch
Ubiquitous expression of mutant Cu/Zn-superoxide dismutase (SOD1) selectively affects motor neurons in the central nervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS). The CNS-specific impact of ubiquitous mutant SOD1 expression is recapitulated in transgenic mouse models of the disease. Here we present outcomes for the metallo-complex Cu(II)(atsm) tested for therapeutic efficacy in mice expressing SOD1(G93A) on a mixed genetic background. Oral administration of Cu(II)(atsm) delayed the onset of neurological symptoms, improved locomotive capacity and extended overall survival...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202006/differences-in-serum-oxidative-status-between-glaucomatous-and-nonglaucomatous-cataract-patients
#2
Wojciech Rokicki, Jolanta Zalejska-Fiolka, Dorota Pojda-Wilczek, Alicja Hampel, Wojciech Majewski, Serap Ogultekin, Ewa Mrukwa-Kominek
BACKGROUND: Oxidative stress contributes to both intraocular pressure regulation and glaucomatous neuropathy. The systemic redox status (solitary determination) was examined in primary open-angle glaucoma (POAG) patients with cataract and nonglaucomatous cataract patients. Cataract-matched group comparisons appear more precise in the context of oxidative stress evaluation. The aim of this study was to establish if systemic oxidative status in POAG patients was elevated compared with the cataract only subjects...
February 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28193461/gill-structural-integrity-changes-in-fish-deficient-or-excessive-in-dietary-isoleucine-towards-the-modulation-of-tight-junction-protein-inflammation-apoptosis-and-antioxidant-defense-via-nf-%C3%AE%C2%BAb-tor-and-nrf2-signaling-pathways
#3
Lin Feng, Lu Gan, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Ling Tang, Sheng-Yao Kuang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study firstly aimed to test the impact of dietary isoleucine (Ile) on tight junction protein, inflammation, apoptosis, antioxidant defense and related signaling molecule gene expression in the gill of fish. Young grass carp (Ctenopharyngodon idella) (weighing 256.8 ± 3.5 g) were fed six diets containing graded levels of Ile, namely, 3.8, 6.6, 9.3, 12.5, 15.2 and 18.5 g/kg diet for 8 weeks. The results firstly revealed that Ile deficiency down-regulated the mRNA expressions of claudin-3, claudin-b, claudin-c, occludin and zonula occludens-1 (ZO-1) and up-regulated the mRNA expression of claudin-12, which led to the intercellular structure damage of fish gill...
February 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28192979/structural-characterization-of-native-proteins-and-protein-complexes-by-electron-ionization-dissociation-mass-spectrometry
#4
Huilin Li, Yuewei Sheng, William M McGee, Michael Cammarata, Dustin D Holden, Joseph A Loo
Mass spectrometry (MS) has played an increasingly important role in the identification and structural and functional characterization of proteins. In particular, the use of tandem mass spectrometry has afforded one of the most versatile methods to acquire structural information for proteins and protein complexes. The unique nature of electron capture dissociation (ECD) for cleaving protein backbone bonds while preserving non-covalent interactions has made it especially suitable for the study of native protein structures...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28185390/oxidative-stress-as-a-damage-mechanism-in-porcine-cumulus-oocyte-complexes-exposed-to-malathion-during-in-vitro-maturation
#5
Diana Flores, Verónica Souza, Miguel Betancourt, Mario Teteltitla, Humberto González-Márquez, Eduardo Casas, Edmundo Bonilla, Patricia Ramírez-Noguera, María Concepción Gutiérrez-Ruíz, Yvonne Ducolomb
Malathion is one of the most commonly used insecticides. Recent findings have demonstrated that it induces oxidative stress in somatic cells, but there are not enough studies that have demonstrated this effect in germ cells. Malathion impairs porcine oocyte viability and maturation, but studies have not shown how oxidative stress damages maturation and which biochemical mechanisms are affected in this process in cumulus-oocyte complexes (COCs). The aims of the present study were to determine the amount of oxidative stress produced by malathion in porcine COCs matured in vitro, to define how biochemical mechanisms affect this process, and determine whether trolox can attenuate oxidative damage...
February 10, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28185046/complete-amino-acid-sequence-of-a-copper-zinc-superoxide-dismutase-from-ginger-rhizome
#6
Yuki Nishiyama, Tamo Fukamizo, Kazunari Yoneda, Tomohiro Araki
Superoxide dismutase (SOD) is an antioxidant enzyme protecting cells from oxidative stress. Ginger (Zingiber officinale) is known for its antioxidant properties, however, there are no data on SODs from ginger rhizomes. In this study, we purified SOD from the rhizome of Z. officinale (Zo-SOD) and determined its complete amino acid sequence using N terminal sequencing, amino acid analysis, and de novo sequencing by tandem mass spectrometry. Zo-SOD consists of 151 amino acids with two signature Cu/Zn-SOD motifs and has high similarity to other plant Cu/Zn-SODs...
February 9, 2017: Protein Journal
https://www.readbyqxmd.com/read/28168414/the-anti-aging-effect-of-erythropoietin-via-the-erk-nrf2-are-pathway-in-aging-rats
#7
Haiqin Wu, Jiaxin Zhao, Mengyi Chen, Huqing Wang, Qingling Yao, Jiaxin Fan, Meng Zhang
Erythropoietin (EPO) has a neuroprotective effect and can resist aging, which most likely occur through EPO increasing the activity of antioxidant enzymes and scavenging free radicals. In this study, we verified the anti-aging function of EPO and discussed the mechanism occurring through the extracellular signal-regulated kinase (ERK)/NF-E2-related factor 2 (Nrf2)-ARE pathway. A rat model of aging was induced by the continuous subcutaneous injection of 5 % D-galactose for 6 weeks. At the beginning of the sixth week, physiological saline or EPO was administered twice per day through a lateral ventricle system for a total of 7 days...
February 6, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28167950/small-one-helix-proteins-are-essential-for-photosynthesis-in-arabidopsis
#8
Jochen Beck, Jens N Lohscheider, Susanne Albert, Ulrica Andersson, Kurt W Mendgen, Marc C Rojas-Stütz, Iwona Adamska, Dietmar Funck
The extended superfamily of chlorophyll a/b binding proteins comprises the Light-Harvesting Complex Proteins (LHCs), the Early Light-Induced Proteins (ELIPs) and the Photosystem II Subunit S (PSBS). The proteins of the ELIP family were proposed to function in photoprotection or assembly of thylakoid pigment-protein complexes and are further divided into subgroups with one to three transmembrane helices. Two small One-Helix Proteins (OHPs) are expressed constitutively in green plant tissues and their levels increase in response to light stress...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28163077/regulation-of-trace-elements-and-redox-status-in-striatum-of-adult-rats-by-long-term-aerobic-exercise-depends-on-iron-uptakes
#9
Hua-Bo Wu, De-Sheng Xiao
We investigated the effects of aerobic exercise (AE) on trace element contents and redox status in the striatum of rats with different diet iron. Weaned female rats were randomly fed with iron-adequate diet (IAD), iron-deficient diet (IDD), and iron-overloaded diet (IOD). After feeding their respective diet for 1 month, the rats fed with same diet were divided into swimming and maintaining sedentary (S) group. After 3 months, the non-heme iron (NHI), Mn, Cu, and Zn in the striatum were measured. Meanwhile, malonaldehyde acid (MDA), total superoxide dismutase activity, hydroxyl radical scavenging activity, and total antioxidant capacity were also analyzed...
February 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28155600/green-tea-camellia-sinensis-protects-against-arsenic-neurotoxicity-via-antioxidative-mechanism-and-activation-of-superoxide-dismutase-activity
#10
Smarajit Maiti, Nirmallya Acharyya, Tamal K Ghosh, Sk Sajed Ali, Emili Manna, Aarifa Nazmeen, Nirmalya K Sinha
BACKGROUND: Chronic arsenic-exposure even at a low-dose results in the neural impairment and motor/cognitive dysfunction. However, several preventive approaches are made mainly against hepatic/gastrointestinal damages. Only a few investigations postulate therapeutic strategies for neural anomalies. Here, the protective role of Green tea (Camellia sinensis or CS; 10mg/ml aqueous) has been evaluated against arsenic-induced (0.6ppm/100g bw/28 days) cerebral/cerebellar tissue degeneration, oxidative-threats and neurotransmitter deregulation in female rats...
February 1, 2017: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28133519/chronopharmacological-effects-of-growth-hormone-on-the-executive-function-and-oxidative-stress-response-in-rats
#11
Carlos K B Ferrari, Eduardo L França, Luciane A Monteiro, Bruno L Santos, Alfredo Pereira-Junior, Adenilda C Honorio-França
OBJECTIVES: To investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. MATERIALS AND METHODS: Fifty male Wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn superoxide dismutase (Cu, Zn-SOD), and superoxide release by spleen macrophages were evaluated...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28124772/expression-and-distribution-of-arylsulfatase-b-are-closely-associated-with-neuron-death-in-sod1-g93a-transgenic-mice
#12
Jie Zhang, Huiting Liang, Lei Zhu, Weiming Gan, Chunyan Tang, Jiao Li, Renshi Xu
The known proteins only explained the partial pathogenesis of amyotrophic lateral sclerosis (ALS). Therefore, this study aimed to search the novel proteins possibly involved in ALS. In this study, we analyzed the expression and distribution of the candidate protein arylsulfatase B (ARSB) in the different segments, anatomic regions, and neural cells of spinal cord at the different stages of the wild-type and [Cu/Zn] superoxide dismutase 1 (SOD1) G93A transgenic mice using the fluorescent immunohistochemistry and the western blot...
January 26, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28120938/s-acylation-of-sod1-ccs-and-a-stable-sod1-ccs-heterodimer-in-human-spinal-cords-from-als-and-non-als-subjects
#13
Sarah E Antinone, Ghanashyam D Ghadge, Lyle W Ostrow, Raymond P Roos, William N Green
Previously, we found that human Cu, Zn-superoxide dismutase (SOD1) is S-acylated (palmitoylated) in vitro and in amyotrophic lateral sclerosis (ALS) mouse models, and that S-acylation increased for ALS-causing SOD1 mutants relative to wild type. Here, we use the acyl resin-assisted capture (acyl-RAC) assay to demonstrate S-acylation of SOD1 in human post-mortem spinal cord homogenates from ALS and non-ALS subjects. Acyl-RAC further revealed that endogenous copper chaperone for SOD1 (CCS) is S-acylated in both human and mouse spinal cords, and in vitro in HEK293 cells...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28119399/an-als-associated-mutant-sod1-rapidly-suppresses-kcnt1-slack-na-activated-k-channels-in-aplysia-neurons
#14
Yalan Zhang, Weiming Ni, Arthur L Horwich, Leonard K Kaczmarek
: Mutations that alter levels of Slack (KCNT1) Na(+)-activated K(+) current produce devastating effects on neuronal development and neuronal function. We now find that Slack currents are rapidly suppressed by oligomers of mutant human Cu/Zn superoxide dismutase 1 (SOD1), which are associated with motor neuron toxicity in an inherited form of amyotrophic lateral sclerosis (ALS). We recorded from bag cell neurons of Aplysia Californica, a model system to study neuronal excitability. We found that injection of fluorescent wild-type SOD1 (wt SOD1YFP) or monomeric mutant G85R SOD1YFP had no effect on net ionic currents measured under voltage clamp...
January 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28118364/physical-and-flavor-characteristics-fatty-acid-profile-antioxidant-status-and-nrf2-dependent-antioxidant-enzyme-gene-expression-changes-in-young-grass-carp-ctenopharyngodon-idella-fillets-fed-dietary-valine
#15
Jian-Bo Luo, Lin Feng, Wei-Dan Jiang, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study was conducted to examine the effects of dietary valine on the physical and flavor characteristics, fatty acid (FA) profile, antioxidant status and Nrf2-dependent antioxidant enzyme gene expression in the muscle of young grass carp (Ctenopharyngodon idella) fed increasing levels of valine (4.3, 8.0, 10.6, 13.1, 16.9 and 19.1 g/kg) for 8 weeks. Compared with the control group, the group fed valine showed improved physical characteristics of fish fillets (increased relative shear force, hydroxyproline, protein and lipid levels and decreased cathepsin B and L activities, as well as cooking loss, were observed)...
2017: PloS One
https://www.readbyqxmd.com/read/28116642/evaluation-of-oxidative-stress-biomarkers-in-aiolopus-thalassinus-orthoptera-acrididae-collected-from-areas-polluted-by-the-fertilizer-industry
#16
Hesham A Yousef, Eman A Abdelfattah, Maria Augustyniak
The waste products of the fertilizer industry such as heavy metals, but especially phosphates and sulphates, are a serious problem that influences the structure and functioning of ecosystems. The levels of Cd, Pb, Zn, Cu, sulphates and phosphates were measured in soil samples from four sites: a control and sites that were 1, 3 and 6 km (sites A-C) away from the Abu-Zaabal Fertilizer Company. Oxidative stress markers (protein carbonyls, lipid peroxides), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), polyphenoloxidase (PPO) and ascorbate peroxidase (APOX)) were evaluated in the tissues of Aiolopus thalassinus, collected from the corresponding sites...
January 23, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28116602/variation-in-oxidative-stress-indices-of-two-green-seaweeds-growing-under-different-heavy-metal-stresses
#17
Gehan A Ismail, Mona M Ismail
Concentrations of nine heavy metals (Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn) were determined in the green seaweed species Cladophora glomerata and Ulva compressa collected from El-Mex and Sidi Kirayr locations. The heavy metal concentrations in algal tissues were in direct correlation with their soluble concentrations in seawater with the descending order: Fe<Mn<Zn<Cu<Cr<Pb<Ni<Cd<Co. The bioaccumulation factor of iron and copper was higher in both tested species collected from El-Mex, while it was maximum for cadmium in Sidi Kirayr location...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28113116/metabolic-interference-of-sod-gene-mutations-on-catalase-activity-in-escherichia-coli-exposed-to-gramoxone%C3%A2-paraquat-herbicide
#18
Fernanda Gravina, Tatiane Dobrzanski, Luiz R Olchanheski, Carolina W Galvão, Péricles M Reche, Sonia A Pileggi, Ricardo A Azevedo, Michael J Sadowsky, Marcos Pileggi
Herbicides are continuously used to minimize the loss of crop productivity in agricultural environments. They can, however, cause damage by inhibiting the growth of microbiota via oxidative stress, due to the increased production of reactive oxygen species (ROS). Cellular responses to ROS involve the action of enzymes, including superoxide dismutase (SOD) and catalase (CAT). The objective of this study was to evaluate adaptive responses in Escherichia coli K-12 to paraquat, the active ingredient in the herbicide Gramoxone®...
January 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28111444/effects-of-zinc-bearing-palygorskite-supplementation-on-the-growth-performance-hepatic-mineral-content-and-antioxidant-status-of-broilers-at-early-age
#19
Weili Yang, Yueping Chen, Yefei Cheng, Chao Wen, Yanmin Zhou
Objective: This study was conducted to investigate effects of zinc (Zn) bearing palygorskite (ZnPal) supplementation on growth performance, hepatic mineral content, and antioxidant status of broilers at early age. Methods: 240 1-day-old Arbor Acres broiler chicks were allocated into 5 treatments with 6 replicates of 8 chicks each. Birds in 5 treatments were fed a basal diet supplemented with 0 (Control group), 20, 40, 60, and 80 mg/kg Zn as ZnPal for 21 days, respectively...
January 2, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28108862/effects-of-chromium-methionine-supplementation-with-different-sources-of-zinc-on-growth-performance-carcass-traits-meat-quality-serum-metabolites-endocrine-parameters-and-the-antioxidant-status-in-growing-finishing-pigs
#20
Xiao Xu, Li Liu, Shen-Fei Long, Xiang-Shu Piao, Terry L Ward, Fei Ji
This experiment was conducted to evaluate the effects of chromium methionine with/without zinc sulfate or zinc amino acid complex on the growth performance, carcass traits, meat quality, serum parameters, endocrine parameters, and antioxidant status of growing-finishing pigs. A total of 180 (32.0 ± 1.7 kg body weight, BW) crossbred pigs (Duroc × Landrace × Yorkshire) were used in a completely randomized design with three dietary treatments and 10 replicates per treatment (five pens of barrows and five pens of gilts with six pigs per replicate)...
January 21, 2017: Biological Trace Element Research
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