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Cu Zn superoxide dismutase

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https://www.readbyqxmd.com/read/29154829/a-role-for-candida-albicans-superoxide-dismutase-enzymes-in-glucose-signaling
#1
Chynna N Broxton, Bixi He, Vincent M Bruno, Valeria C Culotta
The Saccharomyces cerevisiae and Candida albicans yeasts have evolved to differentially use glucose for fermentation versus respiration. S. cerevisiae is Crabtree positive, where glucose represses respiration and promotes fermentation, while the opportunistic fungal pathogen C. albicans is Crabtree negative and does not repress respiration with glucose. We have previously shown that glucose control in S. cerevisiae involves the antioxidant enzyme Cu/Zn superoxide dismutase (SOD1), where H2O2 generated by SOD1 stabilizes the casein kinase YCK1 for glucose sensing...
November 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29144200/mechanisms-underlying-melatonin-mediated-prevention-of-fenvalerate-induced-behavioral-and-oxidative-toxicity-in-zebrafish
#2
Jingjing Han, Cheng Ji, Yichen Guo, Rui Yan, Ting Hong, Yuanyan Dou, Yan An, Shasha Tao, Fenju Qin, Jihua Nie, Chen Ji, Han Wang, Jian Tong, Wei Xiao, Jie Zhang
The neurotoxic effects attributed to the pesticide fenvalerate (FEN) are well-established. The aim of this study was to determine whether melatonin (MLT) was able to protect against FEN-induced behavior, oxidative stress, apoptosis, and neurogenesis using zebrafish (Danio rerio) model. Zebrafish exposed to 100 μg/L FEN for 120 h exhibited decreased swimming activity accompanied by downregulated expression of neurogenesis-related genes (Dlx2, Shha, Ngn1, Elavl3, and Gfap), suggesting that neurogenesis were impaired...
November 16, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29143931/antioxidant-enzyme-activities-of-folsomia-candida-and-avoidance-of-soil-metal-contamination
#3
Wencai Dai, Xin Ke, Zhu Li, Ming Gao, Longhua Wu, Peter Chiristie, Yongming Luo
Induction of the antioxidant enzymes catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) and the avoidance of potentially toxic metals in soil by Folsomia candida were investigated. Both laboratory-spiked and field-polluted agricultural soils were used. Cadmium (Cd) concentrations in body tissues, animal avoidance behaviour and physico-chemical properties of the field soils were also determined. In laboratory Cd-spiked soils, the CAT and SOD activities in the Cd treatments were 71.1-94.7 and 1.31-4...
November 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29142618/melatonin-supplementation-lowers-oxidative-stress-and-regulates-adipokines-in-obese-patients-on-a-calorie-restricted-diet
#4
Karolina Szewczyk-Golec, Paweł Rajewski, Marcin Gackowski, Celestyna Mila-Kierzenkowska, Roland Wesołowski, Paweł Sutkowy, Marta Pawłowska, Alina Woźniak
Obesity is one of the major global health problems. Melatonin deficiency has been demonstrated to correlate with obesity. The aim of the study was to estimate the effect of melatonin on oxidative stress and adipokine levels in obese patients on a calorie-restricted diet. Thirty obese patients were supplemented with a daily dose of 10 mg of melatonin (n = 15) or placebo (n = 15) for 30 days with a calorie-restricted diet. Serum levels of melatonin, 4-hydroxynonenal (HNE), adiponectin, omentin-1, leptin, and resistin, as well as erythrocytic malondialdehyde (MDA) concentration and Zn/Cu-superoxide dismutase, catalase, and glutathione peroxidase (GPx) activities, were measured at baseline and after supplementation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29135932/extracts-of-crataegus-oxyacantha-and-rosmarinus-officinalis-attenuate-ischemic-myocardial-damage-by-decreasing-oxidative-stress-and-regulating-the-production-of-cardiac-vasoactive-agents
#5
Raúl Enrique Cuevas-Durán, Juan Carlos Medrano-Rodríguez, María Sánchez-Aguilar, Elizabeth Soria-Castro, María Esther Rubio-Ruíz, Leonardo Del Valle-Mondragón, Alicia Sánchez-Mendoza, Juan Carlos Torres-Narvaéz, Gustavo Pastelín-Hernández, Luz Ibarra-Lara
Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction. Crataegus oxyacantha (Co) and Rosmarinus officinalis (Ro) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from Co and Ro on the myocardial damage associated with the oxidative status and to the production of different vasoactive agents. Rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); (c) Ro extract-treated myocardial infarction (MI-Ro); (d) Co extract-treated myocardial infarction (MI-Co); or (e) Ro+Co-treated myocardial infarction (MI-Ro+Co)...
November 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29133823/identification-of-mirna-mediated-drought-responsive-multi-tiered-regulatory-network-in-drought-tolerant-rice-nagina-22
#6
Sonia Balyan, Mukesh Kumar, Roseeta Devi Mutum, Utkarsh Raghuvanshi, Priyanka Agarwal, Saloni Mathur, Saurabh Raghuvanshi
Comparative characterization of microRNA-mediated stress regulatory networks in contrasting rice cultivars is critical to decipher plant stress response. Consequently, a multi-level comparative analysis, using sRNA sequencing, degradome analysis, enzymatic and metabolite assays and metal ion analysis, in drought tolerant and sensitive rice cultivars was conducted. The study identified a group of miRNAs "Cultivar-specific drought responsive" (CSDR)-miRNAs (osa-miR159f, osa-miR1871, osa-miR398b, osa-miR408-3p, osa-miR2878-5p, osa-miR528-5p and osa-miR397a) that were up-regulated in the flag-leaves of tolerant cultivar, Nagina 22 (N22) and Vandana, but down-regulated in the sensitive cultivar, Pusa Basmati 1 (PB1) and IR64, during drought...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133349/the-role-of-calprotectin-in-withholding-zinc-and-copper-from-candida-albicans
#7
Angelique N Besold, Benjamin A Gilston, Jana N Radin, Christian Ramsoomair, Edward M Culbertson, Cissy X Li, Brendan P Cormack, Walter J Chazin, Thomas E Kehl-Fie, Valeria C Culotta
The opportunistic fungal pathogen Candida albicans acquires essential metals from the host, yet the host can sequester these micronutrients through a process known as nutritional immunity. How the host withholds metals from C. albicans was poorly understood and here we examine the role of calprotectin (CP), a transition metal binding protein. When CP depletes bioavailable Zn from the extracellular environment, C. albicans strongly upregulates ZRT1 and PRA1 for Zn import and maintains constant intracellular Zn through numerous cell divisions...
November 13, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29113862/comparative-expression-analysis-of-immune-related-factors-in-the-sea-cucumber-apostichopus-japonicus
#8
Jingwei Jiang, Zunchun Zhou, Ying Dong, Zelong Zhao, Hongjuan Sun, Bai Wang, Bei Jiang, Zhong Chen, Shan Gao
In order to preliminarily explore the joint involvement of different immune-related factors during the same immune process in Apostichopus japonicus, the transcriptional expression of Cu/Zn superoxide dismutase (Cu/Zn-SOD), catalase (CAT), c-type lysozyme (c-LYZ), i-type lysozyme (i-LYZ), cathepsin D, melanotransferrin (MTF), Toll, c-type lectin (c-LCT) and complement 3 (C3) during the development from fertilized eggs to juveniles and after challenging the juveniles with Vibrio splendidus, Pseudoalteromonas nigrifaciens, Shewanella baltica and Bacillus cereus, respectively, was measured using the method of quantitative real-time PCR (qRT-PCR), and then the correlations among different immune-related factors were analyzed...
November 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29104236/the-emerging-role-of-the-major-histocompatibility-complex-class-i-in-amyotrophic-lateral-sclerosis
#9
REVIEW
Gabriela Bortolança Chiarotto, Giovanni Nardo, Maria Chiara Trolese, Marcondes Cavalcante França, Caterina Bendotti, Alexandre Leite Rodrigues de Oliveira
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motoneurons (MNs). The etiology of the disease is still unknown for most patients with sporadic ALS, while in 5-10% of the familial cases, several gene mutations have been linked to the disease. Mutations in the gene encoding Cu, Zn superoxide dismutase (SOD1), reproducing in animal models a pathological scenario similar to that found in ALS patients, have allowed for the identification of mechanisms relevant to the ALS pathogenesis...
November 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29096261/neonicotinoid-insecticides-imidacloprid-guadipyr-and-cycloxaprid-induce-acute-oxidative-stress-in-daphnia-magna
#10
Suzhen Qi, Donghui Wang, Lizhen Zhu, Miaomiao Teng, Chengju Wang, Xiaofeng Xue, Liming Wu
Cycloxaprid (CYC) and guadipyr (GUA) are two new and promising neonicotinoid insecticides whose effects on Daphnia magna are as yet unknown. In this study, the acute toxicities of CYC and GUA to D. magna, including immobilization and embryo-hatching inhibition, and their effects on antioxidant enzymes and related gene expression were determined after a 48-h exposure. Imidacloprid (IMI) was evaluated at the same time as a reference agent. The 48-h EC50 values of IMI, GUA, and CYC for neonate immobilization were 13...
October 30, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29093992/inorganic-organic-and-encapsulated-minerals-in-vegetable-meal-based-diets-for-sparus-aurata-linnaeus-1758
#11
David Domínguez, Simona Rimoldi, Lidia E Robaina, Silvia Torrecillas, Genciana Terova, María J Zamorano, Vasileios Karalazos, Kristin Hamre, Marisol Izquierdo
Substituting fishmeal (FM) with vegetable meal (VM) can markedly affect the mineral composition of feeds, and may require additional mineral supplementation. Their bioavailability and optimal supplementation levels depend also on the form of delivery of minerals. The aim of the study was to determine the effect of different delivery forms of three major trace elements (Zn, Mn and Se) in a marine teleost. Gilthead sea bream juveniles of 22.5 g were fed a VM-based diet for 12 weeks that was either not supplemented with these minerals or supplemented with inorganic, organic, or encapsulated inorganic forms of minerals in triplicate and compared to a FM-based diet...
2017: PeerJ
https://www.readbyqxmd.com/read/29089887/cilostazol-suppresses-a%C3%AE-induced-neurotoxicity-in-sh-sy5y-cells-through-inhibition-of-oxidative-stress-and-mapk-signaling-pathway
#12
Tatsunori Oguchi, Ran Ono, Mayumi Tsuji, Hidenobu Shozawa, Masayuki Somei, Manami Inagaki, Yukiko Mori, Taro Yasumoto, Kenjiro Ono, Yuji Kiuchi
Alzheimer's disease (AD) is a slowly progressive form of dementia, characterized by memory impairment and cognitive dysfunction. AD is mainly characterized by the deposition of amyloid β (Aβ) plaques and intracellular neurofibrillary tangles in the brain, along with neuronal degeneration and high levels of oxidative stress. Cilostazol (CSZ) was recently found to suppress the progression of cognitive decline in patients with stable AD receiving acetylcholinesterase inhibitors. This present study aimed to clarify the mechanism by which CSZ protects neurons from degeneration associated with Aβ(1-42)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29073523/molecular-oxidative-stress-markers-in-olive-ridley-turtles-lepidochelys-olivacea-and-their-relation-to-metal-concentrations-in-wild-populations
#13
Adriana A Cortés-Gómez, Patricia Morcillo, Francisco A Guardiola, Cristobal Espinosa, María A Esteban, Alberto Cuesta, Marc Girondot, Diego Romero
Due to their longevity and extensive migration areas, marine turtles are able to accumulate diverse contaminants over many years and as a consequence they represent an interesting bioindicator species for marine ecosystem pollution. Metals provoke toxicological effects in many aquatic animal species, but marine turtles have been under-investigated in this area. Thus, we have determined the presence of certain inorganic elements (As, Cd, Cu, Ni, Pb, Se and Zn) in olive ridley turtles (Lepidochelys olivacea) and related them to metallothionein (MT), superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) transcription and/or enzymatic activities...
October 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29068537/anti-fibrotic-function-of-cu-bearing-stainless-steel-for-reducing-recurrence-of-urethral-stricture-after-stent-implantation
#14
Jing Zhao, Ling Ren, Meixia Liu, Tong Xi, Bingchun Zhang, Ke Yang
Recurrent stenosis is the main reason inducing the failure of urethral stricture treatment. Our previous study has found that the 316L type Cu bearing stainless steel (316L-Cu SS) showed antimicrobial activity and anti-encrustation performance when it was used for relieving urethral obstructer. However, whether it can reduce the occurrence of fibrosis or not, we need further investigation to compare the cellular and molecular responses of human urethral scar fibroblast cells (USFCs) on 316L-Cu SS and medical grade 316L stainless (316L SS, as a control)...
October 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29065820/recent-advances-in-antabuse-disulfiram-the-importance-of-its-metal-binding-ability-to-its-anticancer-activity
#15
Maricela Viola-Rhenals, Kush Rohit Patel, Laura Jaimes-Santamaria, Guojun Wu, Jinbao Liu, Q Ping Dou
Disulfiram (DSF, also called tetraethylthiuram disulphide), a disulfide derivative of N,N-diethyldithiocarbamate (DEDTC), is an antialcoholism drug that is currently being repurposed as a promising anticancer drug. DSF has been investigated in many studies, including in vitro, in vivo, preclinical and clinical. Various mechanisms have been proposed to be responsible for the cytotoxic effect of DSF on cancer cells. DSF is a pro-drug which is converted to its metabolite DEDTC in human body. A complex of DEDTC with a metal ion [usually Cu(II) or Zn(II)] could be responsible for the anticancer activity of DSF in breast, prostate, glioblastoma, lung, melanoma, cervical, colorectal cancers as well as myeloma and leukemia...
October 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29065402/vitamin-e-coated-dialyzer-inhibits-oxidative-stress
#16
Shiho Yamadera, Yuya Nakamura, Masahiro Inagaki, Isao Ohsawa, Hiromichi Gotoh, Yoshikazu Goto, Naoki Sato, Tatsunori Oguchi, Yurika Gomi, Mayumi Tsuji, Yuji Kiuchi, Shinichi Iwai
AIM: To examine the effects of vitamin E-coated dialyzer on oxidative stress in vitro. METHODS: A dialyzer with a synthetic polymer membrane (APS-11SA) and vitamin E-coated dialyzer (VPS-11SA) were connected to a blood tubing line, and U937 cells were circulated in the device. The circulating fluid was collected at 1, 2, 5, 10, 25, and 50 cycles, which are estimated numbers of passes through the dialyzer. Intracellular reactive oxygen species (ROS) production, malondialdehyde (MDA), and Cu/Zn-superoxide dismutase (SOD) were quantified...
October 25, 2017: Blood Purification
https://www.readbyqxmd.com/read/29059196/exogenous-dietary-lysozyme-improves-the-growth-performance-and-gut-microbiota-in-broiler-chickens-targeting-the-antioxidant-and-non-specific-immunity-mrna-expression
#17
Mervat A Abdel-Latif, Ali H El-Far, Ahmed R Elbestawy, Rania Ghanem, Shaker A Mousa, Hatem S Abd El-Hamid
Supplementation of exogenous enzymes in chickens has been widely practiced, yet mechanisms responsible are not fully delineated. To investigate the effects of the dietary lysozyme on the growth performance and immunity of broiler chickens, a total of 120 one-day-old Ross 308 chicks were randomly allocated into four groups, each having three replicates (30 birds/group). The chicks were fed the starter (1-21 d) and grower (22-35 d) diets supplemented with 0 (control), 70 (LYZ70), 90 (LYZ90) and 120 (LYZ120) g of lysozyme 10%® per ton of basal diet for five weeks...
2017: PloS One
https://www.readbyqxmd.com/read/29023387/combination-of-%C3%AE-glucan-and-morus-alba-l-leaf-extract-promotes-metabolic-benefits-in-mice-fed-a-high-fat-diet
#18
Jie Xu, Xiaojie Wang, Ke Cao, Zhizhong Dong, Zhihui Feng, Jiankang Liu
β-glucan (BG) and mulberry have received increasing attention for their benefits as natural sources of metabolic health. In the current study, we investigated the synergetic beneficial effects of BG and mulberry leaf extract (MLE) in mice fed a high-fat diet (HFD). Male C57BL6 mice were fed a HFD for twelve weeks to induce significant obesity and insulin resistance. BG and MLE were administrated orally throughout the feeding period. The administration of BG resulted in a significant reduction in body weight gain, perirenal fat mass, fasting insulin, serum lipids, serum inflammation markers, and fatty liver, showing systemic health improvement...
October 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29022198/gene-disruption-in-scedosporium-aurantiacum-proof-of-concept-with-the-disruption-of-sodc-gene-encoding-a-cytosolic-cu-zn-superoxide-dismutase
#19
Victoire Pateau, Bienvenue Razafimandimby, Patrick Vandeputte, Christopher R Thornton, Thomas Guillemette, Jean-Philippe Bouchara, Sandrine Giraud
Scedosporium species are opportunistic pathogens responsible for a large variety of infections in humans. An increasing occurrence was observed in patients with underlying conditions such as immunosuppression or cystic fibrosis. Indeed, the genus Scedosporium ranks the second among the filamentous fungi colonizing the respiratory tracts of the CF patients. To date, there is very scarce information on the pathogenic mechanisms, at least in part because of the limited genetic tools available. In the present study, we successfully developed an efficient transformation and targeted gene disruption approach on the species Scedosporium aurantiacum...
October 11, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28994034/on-the-interactions-among-zinc-availability-and-responses-to-ozone-stress-in-durum-wheat-seedlings
#20
Margherita G De Biasi, Rosita Marabottini, Anna Rita Paolacci, Mario Ciaffi, Cristina Nali, Giacomo Lorenzini, Maurizio Badiani
Seedlings of durum wheat [Triticum turgidum subsp. durum (Desf.) Husn] were exposed to zinc nutrition and to ozone (O3) in a factorial combination: adequate (+Zn treatment) or no Zn (-Zn) in the nutrient solution, followed by exposure to either ozone-free air (filtered air, FA) or to 150 nL L(-1) ozone (O3) for 4 h. Although omitting Zn from the nutrient solution failed to impose a genuine Zn deficiency, -Zn*FA durum wheat seedlings showed a typical deficiency behaviour, i.e. Zn mobilisation from root to shoot...
October 10, 2017: Environmental Science and Pollution Research International
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