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Cu Zn superoxide dismutase

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https://www.readbyqxmd.com/read/28416257/nrf2-and-regulation-of-the-antioxidant-system-in-the-antarctic-silverfish-pleuragramma-antarctica-adaptation-to-environmental-changes-of-pro-oxidant-pressure
#1
Maria Elisa Giuliani, Maura Benedetti, Marco Nigro, Francesco Regoli
Despite the key importance of Nrf2-Keap1 in regulating antioxidant system in vertebrates, this system is still poorly investigated in marine species. The present study focused on the Antarctic silverfish Pleuragramma antarctica which, during the final phases of embryo development in platelet ice, is challenged by a sudden enhancement of environmental oxidative conditions associated to ice melting. Partial coding sequences were identified for Nrf2, its repressor Keap1 and for typical Nrf2-target antioxidant genes, like catalase, glutathione peroxidase isoform 1 and Cu/Zn-dependent superoxide dismutase...
April 7, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28409332/a-new-mouse-model-of-frailty-the-cu-zn-superoxide-dismutase-knockout-mouse
#2
Sathyaseelan S Deepa, Shylesh Bhaskaran, Sara Espinoza, Susan V Brooks, Anne McArdle, Malcolm J Jackson, Holly Van Remmen, Arlan Richardson
Frailty is a geriatric syndrome that is an important public health problem for the older adults living in the USA. Although several methods have been developed to measure frailty in humans, we have very little understanding of its etiology. Because the molecular basis of frailty is poorly understood, mouse models would be of great value in determining which pathways contribute to the development of frailty. More importantly, mouse models would be critical in testing potential therapies to treat and possibly prevent frailty...
April 13, 2017: GeroScience
https://www.readbyqxmd.com/read/28407763/klotho-ameliorates-oxidized-low-density-lipoprotein-ox-ldl-induced-oxidative-stress-via-regulating-lox-1-and-pi3k-akt-enos-pathways
#3
Yansheng Yao, Yanbing Wang, Yibo Zhang, Chang Liu
BACKGROUND: Atherosclerosis is a common cardiovascular disease that causes myocardial infarction, heart failure, and stroke. Increased oxidized low density lipoprotein (ox-LDL) in the sub-endothelium is the characteristic origin of atherogenesis. Klotho, an anti-aging protein, has been reported to protect against atherosclerosis and ameliorate endothelial dysfunction in vivo. The aim of this study is to investigatethe anti-oxidative activity of Klothoin ox-LDL-treated human umbilical vein endothelial cells (HUVECs)...
April 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28400803/pretreated-quercetin-protects-gerbil-hippocampal-ca1-pyramidal-neurons-from-transient-cerebral-ischemic-injury-by-increasing-the-expression-of-antioxidant-enzymes
#4
Bai Hui Chen, Joon Ha Park, Ji Hyeon Ahn, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Moo-Ho Won, Choong-Hyun Lee, In Koo Hwang, Jong-Dai Kim, Il Jun Kang, Jun Hwi Cho, Bich Na Shin, Yang Hee Kim, Yun Lyul Lee, Seung Min Park
Quercetin (QE; 3,5,7,3',4'-pentahydroxyflavone), a well-known flavonoid, has been shown to prevent against neurodegenerative disorders and ischemic insults. However, few studies are reported regarding the neuroprotective mechanisms of QE after ischemic insults. Therefore, in this study, we investigated the effects of QE on ischemic injury and the expression of antioxidant enzymes in the hippocampal CA1 region of gerbils subjected to 5 minutes of transient cerebral ischemia. QE was pre-treated once daily for 15 days before ischemia...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28391978/recombinant-protein-transduction-domain-cu-zn-superoxide-dismutase-alleviates-bone-cancer-pain-via-peroxiredoxin-4-modulation-and-antioxidation
#5
Wanjun Yao, Haiwen Zhao, Ruoshi Shi, Xiaohui Li, Yang Li, Changbin Ke, Juying Liu
Bone cancer pain (BCP) is a serious chronic clinical condition and reactive oxygen species (ROS) were considered to be involved in its development and persistency. Normally, superoxide dismutase (SOD) converts superoxide anions to hydrogen peroxide (H2O2) and H2O2 is then naturalized to be water by peroxiredoxin 4. We reported previously that recombinant protein transduction domain (PTD)-Cu/Zn SOD effectively scavenged excessive ROS and prevented cardiomyocytes from hypoxia-reoxygenation damage. However, whether PTD-Cu/Zn SOD would prevent BCP development is unknown...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28378219/cardioprotective-effect-of-kr-33889-a-novel-parp-inhibitor-against-oxidative-stress-induced-apoptosis-in-h9c2-cells-and-isolated-rat-hearts
#6
Eun-Seok Park, Do-Hyun Kang, Jun Chul Kang, Yong Chang Jang, Min-Ju Lee, Hun-Jong Chung, Kyu Yang Yi, Dae-Eun Kim, Bokyung Kim, Hwa-Sup Shin
Oxidative stress plays a critical role in cardiac injury during ischemia/reperfusion (I/R). Despite a potent cardioprotective activity of KR-33889, a novel poly (ADP-ribose) polymerase inhibitor, its underlying mechanism remains unresolved. This study was designed to investigate the protective effects of KR-33889 against oxidative stress-induced apoptosis in rat cardiomyocytes H9c2 cells and isolated rat hearts. H2O2 caused severe injury to H9c2 cells, mainly due to apoptosis, as revealed by TUNEL assay. However, KR-33889 pretreatment significantly attenuated H2O2-induced apoptosis of H9c2 cells, which was accompanied by decrease in expression of both cleaved caspase-3 and Bax and increase in Bcl-2 expression and the ratio of Bcl-2/Bax...
April 4, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28350115/transition-and-heavy-metals-compared-to-oxidative-parameter-balance-in-patients-with-deep-vein-thrombosis-a-case-control-study
#7
Margherita Ferrante, Maria Fiore, Gea Oliveri Conti, Valerio Fiore, Alfina Grasso, Chiara Copat, Salvatore Santo Signorelli
Our study compared copper (Cu), zinc (Zn) and manganese (Mn), crucial for human normal physio-logy maintenance, and lead (Pb) levels as environmental pollutant, in subjects suffering of deep vein thrombosis of lower limbs (DVTs) vs. healthy subjects. Furthermore, we evaluated oxidative stress parameters, the thiobarbituric acid reactive substances (TBARS) as the sum of malondialdehyde or 1,1,3,3-tetraethoxypropane (MDA) and 4-hydroxynonenal 4-HNE) and cytosolic superoxide dismutase (Cu/Zn-SOD) concentrations in both groups...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28344087/subacute-alcohol-and-or-disulfiram-intake-affects-bioelements-and-redox-status-in-rat-testes
#8
Ana Djuric, Aida Begic, Borko Gobeljic, Ana Pantelic, Goran Zebic, Ivana Stevanovic, Dragan Djurdjevic, Milica Ninkovic, Vera Prokic, Ivan Stanojevic, Danilo Vojvodic, Mirjana Djukic
The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C21/C42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A1-21 groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A21+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol)...
March 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28344074/aberrant-distributions-of-nuclear-pore-complex-proteins-in-als-mice-and-als-patients
#9
Jingwei Shang, Toru Yamashita, Yumiko Nakano, Ryuta Morihara, Xianghong Li, Tian Feng, Xia Liu, Yong Huang, Yusuke Fukui, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
Nuclear pore complexes (NPCs) play important roles in traffic of molecules between the nucleus and cytoplasm, aberrant distributions of components of NPCs were demonstrated in C9orf72 amyotrophic lateral sclerosis (C9-ALS) patients, but it is elusive whether such abnormities are also the case with other cause of ALS disease. In the present study, we investigated the spatiotemporal distributions of RanGAP1 and 4 representative nucleoporins (GP210, NUP205, NUP107 and NUP50) of NPCs in human Cu/Zn superoxide dismutase-1 mutation transgenic (SOD1-Tg) mice and sporadic ALS patients...
March 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28339968/optimization-of-dietary-zinc-for-egg-production-and-antioxidant-capacity-in-chinese-egg-laying-ducks-fed-a-diet-based-on-corn-wheat-bran-and-soybean-meal
#10
W Chen, S Wang, H X Zhang, D Ruan, W G Xia, Y Y Cui, C T Zheng, Y C Lin
The aim of this study was to evaluate the effect of zinc supplementation on productive performance and antioxidant status in laying ducks. Five-hundred-four laying ducks were divided into 7 treatments, each containing 6 replicates of 12 ducks. The ducks were caged individually and fed a corn-soybean meal and wheat bran basal diet (37 mg Zn/kg) or the basal diet supplemented with 15, 30, 45, 60, 75, or 90 mg Zn/kg (as zinc sulfate). During the early laying period of 10 d (daily egg production <80%), egg production, daily egg mass, and FCR increased quadratically with increasing dietary Zn levels (P < 0...
March 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/28338762/redox-and-reactive-oxygen-species-network-in-acclimation-for-salinity-tolerance-in-sugar-beet
#11
M Sazzad Hossain, Abdelaleim Ismail ElSayed, Marten Moore, Karl-Josef Dietz
Fine-tuned and coordinated regulation of transport, metabolism and redox homeostasis allows plants to acclimate to osmotic and ionic stress caused by high salinity. Sugar beet is a highly salt tolerant crop plant and is therefore an interesting model to study sodium chloride (NaCl) acclimation in crops. Sugar beet plants were subjected to a final level of 300 mM NaCl for up to 14 d in hydroponics. Plants acclimated to NaCl stress by maintaining its growth rate and adjusting its cellular redox and reactive oxygen species (ROS) network...
February 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28338001/renin-angiotensin-system-acting-on-reactive-oxygen-species-in-paraventricular-nucleus-induces-sympathetic-activation-via-at1r-pkc%C3%AE-rac1-pathway-in-salt-induced-hypertension
#12
Qing Su, Chan-Juan Huo, Hong-Bao Li, Kai-Li Liu, Xiang Li, Qing Yang, Xin-Ai Song, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kang
Brain renin-angiotensin system (RAS) could regulate oxidative stress in the paraventricular nucleus (PVN) in the development of hypertension. This study was designed to explore the precise mechanisms of RAS acting on reactive oxygen species (ROS) in salt-induced hypertension. Male Wistar rats were administered with a high-salt diet (HS, 8.0% NaCl) for 8 weeks to induced hypertension. Those rats were received PVN infusion of AT1R antagonist losartan (LOS, 10 μg/h) or microinjection of small interfering RNAs for protein kinase C γ (PKCγ siRNA) once a day for 2 weeks...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336092/physiological-and-biochemical-responses-of-salix-integra-thunb-under-copper-stress-as-affected-by-soil-flooding
#13
Yini Cao, Chuanxin Ma, Guangcai Chen, Jianfeng Zhang, Baoshan Xing
To explore the joint effect of copper (Cu) and flooding on Salix integra Thunb. (S. integra), the physiological and biochemical parameters of the seedlings grown in Cu amended soil (50, 150, 450 mg kg(-1)) with or without the flooding for 60 days were evaluated. The results suggested that the flooding significantly inhibited the root growth in terms of root length and root tips. The Cu exposures of 50 and 150 mg kg(-1) notably enhanced the root growth as compared to the control. Majority of Cu was accumulated in S...
March 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28331914/effects-and-mechanisms-of-a-new-multivitamin-on-chronic-metabolic-syndromes-and-aging
#14
Su-Xi Wu, Xuewei Jiang, Yu-Ying Liu, Lin-Feng Chen, Jun Tao
BACKGROUND: Increased occurrence of chronic syndromes has prompted researchers to investigate and develop drugs and methods for controlling chronic syndromes with a view to improve human health and reduce early aging. MATERIAL AND METHODS: Human trials: After the allotted multivitamin pills or placebo pills had been taken for a stipulated period of about 2 months, the volunteers filled out feedback forms on curative effects of the pills in line with the health examination reports...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28321933/exploring-the-cause-of-aggregation-and-reduced-zn-binding-affinity-by-g85r-mutation-in-sod1-rendering-amyotrophic-lateral-sclerosis
#15
E Srinivasan, R Rajasekaran
Amyotrophic lateral sclerosis (ALS), a lethal neurodegenerative disorder is characterized by the degeneration of upper and lower motor neuron. ALS occurs due to various notably prominent missense mutations, in gene encoding Cu-Zn superoxide dismutase (SOD1) thereby leading to aggregation, dysfunction and reduced Zn binding affinity. In this study, one such mutation, G85R was explored in comparison with wild type SOD1, using discrete molecular dynamics (DMD). Accordingly, the conformational changes were significantly observed in mutant SOD1, through various geometrical parameters, which substantiated the difference in conformational deviation, flexibility and compactness, thus stipulating a root cause for aggregation...
March 21, 2017: Proteins
https://www.readbyqxmd.com/read/28315056/degradation-of-n-alkanes-and-pahs-from-the-heavy-crude-oil-using-salt-tolerant-bacterial-consortia-and-analysis-of-their-catabolic-genes
#16
Ranjit Gurav, Honghong Lyu, Jianli Ma, Jingchun Tang, Qinglong Liu, Hairong Zhang
In the present study, salt-tolerant strains, Dietzia sp. HRJ2, Corynebacterium variabile HRJ4, Dietzia cinnamea HRJ5 and Bacillus tequilensis HRJ6 were isolated from the Dagang oil field, China. These strains degraded n-alkanes and polycyclic aromatic hydrocarbons (PAHs) aerobically from heavy crude oil (HCO) in an experiment at 37 °C and 140 rpm. The GC/MS investigation for degradation of different chain lengths of n-alkanes (C8-C40) by individual strains showed the highest degradation of C8-C19 (HRJ5), C20-C30 (HRJ4) and C31-C40 (HRJ5), respectively...
March 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28299326/production-of-human-cu-zn-sod-with-higher-activity-and-lower-toxicity-in-e-coli-via-mutation-of-free-cysteine-residues
#17
Kun Zhang, Yuejuan Zhang, Jing Zi, Xiaochang Xue, Yi Wan
Although, as an antioxidant enzyme, human Cu,Zn superoxide dismutase 1 (hSOD1) can mitigate damage to cell components caused by free radicals generated by aerobic metabolism, large-scale manufacturing and clinical use of hSOD1 are still limited by the challenge of rapid and inexpensive production of high-quality eukaryotic hSOD1 in recombinant forms. We have demonstrated previously that it is a promising strategy to increase the expression levels of soluble hSOD1 so as to increase hSOD1 yields in E. coli. In this study, a wild-type hSOD1 (wtSOD1) and three mutant SOD1s (mhSOD1s), in which free cysteines were substituted with serine, were constructed and their expression in soluble form was measured...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28291806/effects-of-silicon-on-oryza-sativa-l-seedling-roots-under-simulated-acid-rain-stress
#18
Shuming Ju, Ningning Yin, Liping Wang, Cuiying Zhang, Yukun Wang
Silicon (Si) has an important function in reducing the damage of environmental stress on plants. Acid rain is a serious abiotic stress factor, and Si can alleviate the stress induced by acid rain on plants. Based on these assumptions, we investigated the effects of silicon on the growth, root phenotype, mineral element contents, hydrogen peroxide (H2O2) and antioxidative enzymes of rice (Oryza sativa L.) seedling roots under simulated acid rain (SAR) stress. The results showed that the combined or single effects of Si and/or SAR on rice roots depend on the concentration of Si and the pH of the SAR...
2017: PloS One
https://www.readbyqxmd.com/read/28276489/computational-on-chip-imaging-of-nanoparticles-and-biomolecules-using-ultraviolet-light
#19
Mustafa Ugur Daloglu, Aniruddha Ray, Zoltan Gorocs, Matthew Xiong, Ravinder Malik, Gal Bitan, Euan McLeod, Aydogan Ozcan
Significant progress in characterization of nanoparticles and biomolecules was enabled by the development of advanced imaging equipment with extreme spatial-resolution and sensitivity. To perform some of these analyses outside of well-resourced laboratories, it is necessary to create robust and cost-effective alternatives to existing high-end laboratory-bound imaging and sensing equipment. Towards this aim, we have designed a holographic on-chip microscope operating at an ultraviolet illumination wavelength (UV) of 266 nm...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274448/partial-biochemical-characterization-of-cu-zn-superoxide-dismutase-extracted-from-eggs-of-hens-gallus-gallus-domesticus
#20
J Wawrzykowski, M Kankofer
Biochemical characteristics of Cu,Zn-SOD derived from hen egg white and egg yolk were determined, and compared with those of enzymes from erythrocytes of hens and SOD standard. The presence of dimer with a molecular weight of 33.38±0.34kDa, and pI of 6.30±0.15 was confirmed in samples of SOD extracted from egg yolk. Cu,Zn-SOD isolated from egg yolk had an optimum at pH 6. Average SOD activity in egg yolk was 98.5±19.5U·g(-1) while in egg white reached 6.1±0.8U·g(-1). Changes in SOD activity of the egg yolk during its storage for 200days were also described...
July 15, 2017: Food Chemistry
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