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red blood cell distribution hbv

Xiude Fan, Huan Deng, Xiqiang Wang, Siqi Fu, Zitong Liu, Jiao Sang, Xiaoge Zhang, Na Li, Qunying Han, Zhengwen Liu
BACKGROUND: Red blood cell distribution width (RDW) has been indicated to be an inflammatory indicator in a variety of diseases. However, no consistent conclusions regarding it's relevance to hepatitis B virus (HBV) -related liver diseases have been made. This meta-analysis was conducted to assess the significance of RDW in HBV-related liver diseases. METHODS: A comprehensive literature review was conducted using PubMed, Embase, and China National Knowledge Infrastructure (CNKI) through August 20, 2017 to identify studies that reported the association between RDW and HBV-related liver diseases...
April 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Lei Jin, Yufeng Gao, Jun Ye, Guizhou Zou, Xu Li
BACKGROUND: The red blood cell distribution width (RDW) is increased in chronic liver disease, but its clinical significance in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is still unclear. The aim of the present study was to investigate the clinical significance of RDW in HBV-ACLF patients. METHODS: The medical records of HBV-ACLF patients who were admitted to The Second Affiliated Hospital of Anhui Medical University between April 2012 and December 2015 were retrospectively reviewed...
September 1, 2017: Clinical Laboratory
Yang Kai, Guan Zishu, Guan Shihe, Gao Yufeng, Zhou Qiang
BACKGROUND: Hepatitis B virus (HBV) infection represents a major threat to global public health, especially in China. The clear pathogenesis of chronic HBV infection (CHB) has not been fully elucidated, but inflammation is widely accepted to play an important role. Emerging evidence suggests that red blood cell distribution (RDW) is a novel potential marker of inflammatory responses. The present study aimed to investigate the clinical relevance of elevated RDW in the patients with chronic HBV liver disease ICP...
November 1, 2016: Clinical Laboratory
M-Y Zhu, X Zou, Q Li, D-M Yu, Z-T Yang, D Huang, J Chen, Q-M Gong, D-H Zhang, Y Zhang, L Chen, P-Z Chen, X-X Zhang
Several noninvasive blood biomarkers have been established for the assessment of liver fibrosis in patients with chronic hepatitis B virus (HBV) infection, but their clinical performance remains inconclusive. Here, we compared the diagnostic performance of these biomarkers and developed a novel algorithm for assessing liver fibrosis. Six hundred and sixteen chronically HBV-infected and treatment-naïve patients who underwent liver biopsy were enrolled and randomly divided into training (N=410) and internal validation cohorts (N=206)...
July 2017: Journal of Viral Hepatitis
Wen-Shen Xu, Xiao-Ming Qiu, Qi-shui Ou, Can Liu, Jin-Piao Lin, Hui-Juan Chen, Sheng Lin, Wen-Hua Wang, Shou-Rong Lin, Jing Chen
We aimed to study whether red blood cell distribution width (RDW) could be one of the variables determining the extent of liver fibrosis and inflammation in patients with biopsy-proven hepatitis B. A total of 446 hepatitis B virus-infected patients who underwent liver biopsy were divided into 2 groups: absent or mild and moderate-severe according to the severity of liver fibrosis and inflammation. The independent variables that determine the severity of liver fibrosis and inflammation were explored. RDW values increased with progressive liver fibrosis and inflammation...
March 2015: Medicine (Baltimore)
P Gao, P Xiao, Y L Yang, Q F Chen, X R Mao, Z B Zhao, L Shi, L Z Yang, W Zhou
OBJECTIVE: To evaluate the effect of the viral load on the red blood cell parameters in chronic hepatitis B patients and its clinical significance. METHODS: In the study, 373 chronic hepatitis B patients were recruited, including 123 alanine transaminase (ALT) normal patients (ALT<40 U/L),128 ALT greater than or equal to the upper limit of normal, and less than 2 times higher than the upper limit of normal patients(40 U/L ≤ALT<80 U/L), and 122 ALT greater than or equal to 2 times higher than the upper limit of normal patients (ALT≥80 U/L)...
December 18, 2014: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Ergenekon Karagoz, Asm Ulcay, Alpaslan Tanoglu, Muammer Kara, Vedat Turhan, Hakan Erdem, Oral Oncul, Levent Gorenek
OBJECTIVE: Hepatitis B virus infection is still one of the leading causes of cirrhosis and hepatocellular carcinoma worldwide. Liver biopsy is the gold-standard method to assess the severity of liver fibrosis, but the invasive nature of this method limits its usage. Currently, noninvasive parameters are utilized to estimate liver histology. In the present study, we aimed to investigate the relationship between the severity of fibrosis and red blood cell distribution width (RDW), platelet distribution width (PDW), mean platelet volume (MPV), and MPV and red blood cell distribution width to platelet ratio (RPR) in patients with chronic hepatitis B (CHB)...
December 2014: European Journal of Gastroenterology & Hepatology
Marion Vermeulen, Harry van Drimmelen, Charl Coleman, Josephine Mitchel, Ravi Reddy, Nico Lelie
BACKGROUND: Sensitivity data from a head-to-head comparison study in South Africa were used to compare the efficacy of the Ultrio Plus assay in individual-donation (ID) and minipool (MP)4 and MP8 formats with that of TaqScreen MP6 in preventing hepatitis B virus (HBV) transmission risk. STUDY DESIGN AND METHODS: The replicate nucleic acid test (NAT) results on 106 HBV NAT (Ultrio)-yield samples and 29 HBV DNA (Ultrio)-negative, hepatitis B surface antigen (HBsAg)-positive samples were used to determine the viral load in copies/mL against the Eurohep HBV standard by probit analysis...
October 2014: Transfusion
Baode Chen, Bo Ye, Jian Zhang, Lixiong Ying, Yu Chen
OBJECTIVE: To develop a simple predictive model for significant fibrosis and cirrhosis in chronic hepatitis B (CHB) using the routine hematological parameters of a complete blood count. METHODS: A total of 458 eligible CHB patients who had undergone a liver biopsy were randomly divided into two cohorts: an estimation group (n = 310) and a validation group (n = 148). Liver histology was assessed according to the Metavir scoring scheme. All common demographics, hematological parameters, HBeAg status, HBV DNA, and liver biochemistry were analyzed...
2013: PloS One
Zhide Hu, Yi Sun, Qianqian Wang, Zhijun Han, Yuanlan Huang, Xiaofei Liu, Chunmei Ding, Chengjin Hu, Qin Qin, Anmei Deng
BACKGROUND: Red blood cell distribution width (RDW) is increased in liver disease. Its clinical significance, however, remains largely unknown. The aim of this study was to identify whether RDW was a prognostic index for liver disease. METHODS: We studied, retrospectively, 33 patients with non-cirrhotic HBV chronic hepatitis, 125 patients with liver cirrhosis after HBV infection, 81 newly diagnosed primary hepatocellular carcinoma (pHCC) patients, 17 alcoholic liver cirrhosis patients and 42 patients with primary biliary cirrhosis (PBC)...
July 2013: Clinical Chemistry and Laboratory Medicine: CCLM
YuFeng Lou, ManYi Wang, WeiLin Mao
BACKGROUND: Red blood cell distribution width (RDW), an automated measure of red blood cell size heterogeneity (e.g., anisocytosis) that is largely overlooked, is a newly recognized risk marker in patients with cardiovascular diseases, but its role in persistent viral infection has not been well-defined. The present study was designed to investigate the association between RDW values and different disease states in hepatitis B virus (HBV)-infected patients. In addition, we analyzed whether RDW is associated with mortality in the HBV-infected patients...
2012: PloS One
Nan Zhu, Yi Zhou, Wei-jie Yuan, Jun Liu, Ming-hua Shang, Ling Wang, Li-jie Gu
OBJECTIVE: To investigate the expression and distribution of Toll-like receptor 4 (TLR4) in renal tissue of HBV associated nephropathy (HBV-GN) and its role in the pathogenesis and clinical manifestations of HBV-GN. METHODS: Renal tissues were sampled from 48 HBV-GN patients confirmed by renal biopsy and 154 non-HBV-GN patients. The distribution of TLR4 in renal tissue and the relationship between the distribution of TLR4 and HBsAg were detected by immunohistochemistry...
December 2011: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Li-ping Chen, Chuan Li, Chuan Wang, Tian-fu Wen, Lu-nan Yan, Bo Li
BACKGROUND/AIMS: To identify risk factors of postoperative ascites after hepatectomy for patients with hepatocellular carcinoma (HCC) and hepatitis B virus associated-cirrhosis. METHODOLOGY: The data of 73 patients were reviewed in current study. Pre- and intra-operative variables were retrospectively analyzed using uni- and multi-variate analyses. The diagnostic accuracy of the predictors was evaluated by the receiver operating characteristics (ROC) analysis. RESULTS: Indocyanine green retention rate at 15 minutes (ICGR15) >10%, tumor size >10cm, splenectomy, middle hepatic vein (MHV) resection, red blood cell (RBC) transfusion were risk factors in univariate analysis...
January 2012: Hepato-gastroenterology
Shimian Zou, Fatemeh Musavi, Edward P Notari, Susan L Stramer, Roger Y Dodd
BACKGROUND: The number of apheresis collections increased significantly in recent years; however, data on viral marker rates among these collections are lacking. STUDY DESIGN AND METHODS: Apheresis collection data for 2004 to 2008 were analyzed. All collections were tested for antibodies and viral RNA for human immunodeficiency virus (HIV) and hepatitis C virus (HCV), hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen (anti-HBc), antibody to human T-lymphotropic virus (anti-HTLV), and other markers...
July 2010: Transfusion
Keitaro Sou, Robert Klipper, Beth Goins, Eishun Tsuchida, William T Phillips
Phospholipid vesicles encapsulating concentrated human hemoglobin (Hb-vesicles, HbV), also known as liposomes, have a membrane structure similar to that of red blood cells (RBCs). These vesicles circulate in the bloodstream as an oxygen carrier, and their circulatory half-life times (t(1/2)) and biodistribution are fundamental characteristics required for representation of their efficacy and safety as a RBC substitute. Herein, we report the pharmacokinetics of HbV and empty vesicles (EV) that do not contain Hb, in rats and rabbits to evaluate the potential of HbV as a RBC substitute...
February 2005: Journal of Pharmacology and Experimental Therapeutics
S Matsumura, K Yamaji, H Ohki, K Kosaka, Y Iwashita
Lyophilized PHP as an oxygen carrier is prepared from outdated red cell and dicarboxymethylated polyoxyethylene. In order to apply PHP for a clinical use, a large scale production of high quality PHP has been studied. We have set up a 20 L scale production flow of PHP88. The product was tested to confirm the quality and lot-to-lot consistency. The blood group specific materials were weakly positive in stroma-free hemoglobin (SFH), however, were found negative in the PHP of this scale. The amount of phosphatidylethanolamine (PE) in purified SFH and PHP88 reconstituted solution was 0...
1992: Biomaterials, Artificial Cells, and Immobilization Biotechnology
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