keyword
MENU ▼
Read by QxMD icon Read
search

Calcium cancer

keyword
https://www.readbyqxmd.com/read/28750356/combined-calcitriol-and-menadione-reduces-experimental-murine-triple-negative-breast-tumor
#1
Luciana Bohl, Solange Guizzardi, Valeria Rodríguez, Lucila Hinrichsen, Viviana Rozados, David Cremonezzi, Nori Tolosa de Talamoni, Gabriela Picotto
BACKGROUND: Calcitriol (D) or 1,25(OH)2D3 inhibits the growth of several tumor cells including breast cancer cells, by activating cell death pathways. Menadione (MEN), a glutathione-depleting compound, may be used to potentiate the antiproliferative actions of D on cancer cells. We have previously shown in vitro that MEN improved D-induced growth arrest on breast cancer cell lines, inducing oxidative stress and DNA damage via ROS generation. Treatment with MEN+D resulted more effective than D or MEN alone...
July 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28750038/low-calcium-diet-increases-4t1-mammary-tumor-carcinoma-cell-burden-and-bone-pathology-in-mice
#2
Wendan Wang, Jody L Gordon, Kenneth A Philbrick, Xujuan Yang, Adam J Branscum, Christiane V Löhr, Wanda M Haschek, Russell T Turner, Urszula T Iwaniec, William G Helferich
Breast cancer metastasizes to bone in the majority of patients with advanced disease. We investigated the effects of inadequate dietary calcium (Ca) on bone turnover, tumor growth, and bone response to tumor in tibia inoculated with 4T1 mammary carcinoma cells. Nine-month-old female Balb/c mice were placed on an adequate Ca (5 g/kg diet, n = 30) or low Ca (80 mg/kg diet, n = 31) diet for 14 days, then injected intratibially with 1,000 4T1 cells (transfected with luciferase for bioluminescence imaging), and sacrificed at 5, 10, or 21 days post-inoculation (n = 7-10 mice/group)...
2017: PloS One
https://www.readbyqxmd.com/read/28745885/chemical-synthesis-demonstrates-dynamic-o-glycosylation-regulates-folding-and-functional-conformation-of-a-pivotal-egf12-domain-of-human-notch1-receptor
#3
Shun Hayakawa, Yasuhiro Yokoi, Hiroshi Hinou, Shin-Ichiro Nishimura
The interaction of human NOTCH1 receptor and its ligands is a crucial step to initiate the intracellular signal transductions, in which O-glycosylation of the extracellular EGF-like domain is known to modify this pathway that strongly affects multiple aspects of cell differentiation, development, and cancer biology. In spite of the emerging importance of O-glycosylation in the NOTCH signaling pathway, consequences of this dynamic O-glycosylation processes in ER/Golgi on the folding of functional EGF-like domains re-main unclear...
July 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28744811/evidence-of-vanillin-binding-to-camkiv-explains-the-anti-cancer-mechanism-in-human-hepatic-carcinoma-and-neuroblastoma-cells
#4
Huma Naz, Mohd Tarique, Parvez Khan, Suaib Luqman, Shahzaib Ahamad, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassan
Human calcium/calmodulin-dependent protein kinase IV (CAMKIV) is a member of Ser/Thr kinase family, and is associated with different types of cancer and neurodegenerative diseases. Vanillin is a natural compound, a primary component of the extract of the vanilla bean which possesses varieties of pharmacological features including anti-oxidant, anti-inflammatory, anti-bacterial and anti-tumor. Here, we have investigated the binding mechanism and affinity of vanillin to the CAMKIV which is being considered as a potential drug target for cancer and neurodegenerative diseases...
July 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28744736/management-of-bone-health-in-postmenopausal-women-on-aromatase-inhibitors-ais-a-single-health-care-system-experience
#5
Douglas Tremblay, Vaibhav Patel, Kenneth M Fifer, Jessica Caro, Olivia Kolodka, John Mandelli, Charles L Shapiro
INTRODUCTION: Aromatase inhibitors (AIs) are the preferred therapy for postmenopausal women with early-stage estrogen receptor-positive breast cancers. However, their use causes bone loss and increased risks of osteoporosis and fractures. METHODS: This is a retrospective review of all postmenopausal women with breast cancer diagnosed and treated with AI between 2010 and 2015. Of the 564 women identified, 319 were eligible. RESULTS: The median age at AI initiation was 65 years (range 51-85 years), and the median duration of AI therapy was 28 months (1-72 months)...
July 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28742810/effect-of-calcium-electroporation-in-combination-with-metformin-in-vivo-and-correlation-between-viability-and-intracellular-atp-level-after-calcium-electroporation-in-vitro
#6
Stine Krog Frandsen, Julie Gehl
BACKGROUND: Calcium electroporation is a new experimental anti-cancer treatment where calcium is internalized into cells by application of short, high voltage pulses. Calcium electroporation has been shown to induce tumor necrosis associated with ATP depletion while the effect on normal fibroblasts was limited when investigated in a 3D in vitro spheroid model. We aimed to investigate the effect of calcium electroporation in combination with metformin, a drug that affects intracellular ATP level...
2017: PloS One
https://www.readbyqxmd.com/read/28740830/structure-activity-regulation-and-role-of-the-mitochondrial-calcium-uniporter-in-health-and-disease
#7
REVIEW
Cristina Mammucari, Gaia Gherardi, Rosario Rizzuto
Mitochondrial Ca(2+) uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca(2+) signaling in pathophysiology have been favored by the identification of the genes encoding the mitochondrial calcium uniporter (MCU) and its regulatory subunits. Thus, research carried on in the last years on one hand has determined the structure of the MCU complex and its regulation, on the other has uncovered the consequences of dysregulated mitochondrial Ca(2+) signaling in cell and tissue homeostasis...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28739589/association-of-calcium-calmodulin-dependent-protein-kinase-kinase1-rs7214723-polymorphism-with-lung-cancer-risk-in-a-chinese-population
#8
Da Chen, Fangming Zhong, Ye Chen
Calcium/calmodulin-dependent protein kinase kinase1 (CAMKK1) could specially recognize and activate Calcium/calmodulin-dependent protein kinase (CAMK) I and IV. Furthermore, The activation of CAMK showed positively correlation with proliferation of lung cancer (LC). In addition, A genome-wide association study has identified rs7214723 (E375G) in the CAMKK1 gene as a susceptibility locus for LC in the UK population. Therefore, we conducted a case-control study involving 320 LC patients and 320 controls to validate this conclusion in a Chinese population...
July 24, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28739368/andrographolide-induces-oxidative-stress-dependent-cell-death-in-unicellular-protozoan-parasite-trypanosoma-brucei
#9
Malabika Banerjee, Debaprasad Parai, Pranab Dhar, Manab Roy, Rajib Barik, Subrata Chattopadhyay, Samir Kumar Mukherjee
African sleeping sickness is a parasitic disease in humans and livestock caused by Trypanosoma brucei throughout sub-Saharan Africa. Absence of appropriate vaccines and prevalence of drug resistance proclaim that a new way of therapeutic interventions is essential against African trypanosomiasis. In the present study, we have looked into the effect of andrographolide (andro), a diterpenoid lactone from Andrographis paiculata on Trypanosoma brucei PRA 380. Although andro has been recognized as a promosing anti-cancer drug, its usefulness against Trypanosoma spp remained unexplored...
July 21, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28737925/lipid-bilayer-gated-mesoporous-silica-nanocarriers-for-tumor-targeted-delivery-of-zoledronic-acid-in-vivo
#10
Diti Desai, Jixi Zhang, Jouko Sandholm, Jaakko Lehtimäki, Tove Grönroos, Johanna Tuomela, Jessica M Rosenholm
Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate used for the treatment of bone diseases and calcium metabolism. Anticancer activity of ZOL has been established, but its extraskeletal effects are limited due to its rapid uptake and accumulation to bone hydroxyapatite. In this work, we report on the development of tethered lipid bilayer-gated mesoporous silica nanocarriers (MSNs) for the incorporation, retention and intracellular delivery of ZOL. The in vitro anticancer activity of ZOL-loaded nanocarriers was evaluated by cell viability assay and live-cell imaging...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737489/nfatc2-enhances-tumor-initiating-phenotypes-through-the-nfatc2-sox2-aldh-axis-in-lung-adenocarcinoma
#11
Zhi-Jie Xiao, Jing Liu, Si-Qi Wang, Yun Zhu, Xu-Yuan Gao, Vicky Pui-Chi Tin, Jing Qin, Jun-Wen Wang, Maria Pik Wong
Tumor initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in vivo responses to chemotherapy and targeted therapy. In human lung cancers, high NFATc2 expression predicted poor tumor differentiation, adverse recurrence-free and cancer-specific overall survivals...
July 24, 2017: ELife
https://www.readbyqxmd.com/read/28735581/independent-associations-of-dairy-and-calcium-intakes-with-colorectal-cancers-in-the-adventist-health-study-2-cohort
#12
Yessenia Tantamango-Bartley, Synnove F Knutsen, Karen Jaceldo-Siegl, Jing Fan, Andrew Mashchak, Gary E Fraser
OBJECTIVE: Results associating dairy and Ca intakes with colorectal cancer (CRC) risk have been mixed. Most previous analyses have suffered from confounding between dairy and Ca intakes. We examined independent associations between these variables, also dairy foods, and CRC incidence in a population with a large range of dairy intakes. DESIGN: Adventist Health Study-2 is a cohort study where subjects were enrolled 2002-2007. Proportional hazard regression analyses were performed to estimate hazard ratios (HR)...
July 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28735473/low-concentration-bpaf-and-bpf-induced-cell-biological-effects-are-mediated-by-ros-in-mcf-7-breast-cancer-cells
#13
Bingli Lei, Su Sun, Jie Xu, Chenglian Feng, Yingxin Yu, Gang Xu, Minghong Wu, Wei Peng
Reactive oxygen species (ROS) induced by bisphenol A (BPA) have been implicated in cellular oxidative damage and carcinogenesis. It is not known whether the potential alternatives of BPA, bisphenol AF (BPAF), and bisphenol F (BPF) can also induce ROS involved in mediating biological responses. This study evaluated the toxicity of BPAF and BPF on cell proliferation, DNA damage, intracellular calcium homeostasis, and ROS generation in MCF-7 human breast cancer cells. The results showed that BPAF at 0.001-1 μM and BPF at 0...
July 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28734180/bottom-up-assembly-of-salivary-gland-microtissues-for-assessing-myoepithelial-cell-function
#14
Tugba Ozdemir, Padma Pradeepa Srinivasan, Daniel R Zakheim, Daniel A Harrington, Robert L Witt, Mary C Farach-Carson, Xinqiao Jia, Swati Pradhan-Bhatt
Myoepithelial cells are flat, stellate cells present in exocrine tissues including the salivary glands. While myoepithelial cells have been studied extensively in mammary and lacrimal gland tissues, less is known of the function of myoepithelial cells derived from human salivary glands. Several groups have isolated tumorigenic myoepithelial cells from cancer specimens, however, only one report has demonstrated isolation of normal human salivary myoepithelial cells needed for use in salivary gland tissue engineering applications...
July 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28733551/antihypertensive-drug-use-and-breast-cancer-risk-a-meta-analysis-of-observational-studies
#15
Haibo Ni, Qin Rui, Xiaojue Zhu, Zhenquan Yu, Rong Gao, Huixiang Liu
We conducted a meta-analysis of observational studies to examine the hypothesized association between breast cancer and antihypertensive drug (AHT) use. Fixed- or random- effect models were used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs) for all AHTs and individual classes (i.e., angiotensin-converting enzyme inhibitors, [ACEi]; angiotensin-receptor blockers, [ARBs]; calcium channel blockers, [CCBs]; beta-blockers, [BBs], and diuretics). Twenty-one studies with 3,116,266 participants were included...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732327/prediagnostic-serum-calcium-and-albumin-and-ovarian-cancer-a-nested-case-control-study-in-the-norwegian-janus-serum-bank-cohort
#16
Gary G Schwartz, Steinar Tretli, Linda Vos, Trude E Robsahm
BACKGROUND: Women with higher serum calcium may be more likely to be diagnosed and die of ovarian cancer. We evaluated that finding in a large, prospective cohort. METHODS: We conducted a nested case-control study using a population-based biobank from Norway. We compared 202 ovarian cancer cases and 202 controls, matched for age, date at blood draw, and county of residence, with respect to serum calcium and albumin, adjusted for anthropometric variables. We evaluated risks using the entire follow-up period as well as 2-15 years and 16-25 years ("early" and "late", respectively)...
July 18, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28731294/the-bioinorganic-chemistry-of-lead-in-the-context-of-its-toxicity
#17
Wolfgang Maret
Owing to its abundance on earth and its multiple uses by humans, lead (Pb) is a major toxicant that has threatened human health for millennia and continues to do so. There is no safe level of exposure, necessitating a nuanced approach to its control in the food we consume, the water we drink, and the air we breathe. Turnover in soft tissues is within days. In contrast, lead accumulates in bone and turns over with a half-life of about 30 years, though it can be mobilized from bone under physiological and pathophysiological conditions of bone resorption...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28729416/cib2-negatively-regulates-oncogenic-signaling-in-ovarian-cancer-via-sphingosine-kinase-1
#18
Wenying Zhu, Kate E Jarman, Noor A Lokman, Heidi A Neubauer, Lorena T Davies, Briony L Gliddon, Houng Taing, Paul A B Moretti, Martin K Oehler, Melissa R Pitman, Stuart M Pitson
Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between pro-apoptotic and pro-survival sphingolipids. Oncogenic signaling by SK1 relies on its localization to the plasma membrane, which is mediated by the calcium and integrin binding protein CIB1 via its Ca(2+)-myristoyl switch function. Here we show that another member of the CIB family, CIB2, plays a surprisingly opposite role to CIB1 in the regulation of SK1 signalling. CIB2 bound SK1 on the same site as CIB1, yet it lacks the Ca(2+)-myristoyl switch function...
July 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28728214/p2x-receptor-channels-in-chronic-pain-pathways
#19
REVIEW
Louis-Philippe Bernier, Ariel R Ase, Philippe Séguéla
Chronic pain is a highly prevalent debilitating condition for which treatment options remain limited for many patients. Ionotropic ATP signaling through excitatory and calcium-permeable P2X receptor-channels is now rightfully considered as a critical player in pathological pain generation and maintenance, therefore their selective targeting represents a therapeutic opportunity with promising yet untapped potential. Recent advances in the structural, functional and pharmacological characterization of rodent and human ATP-gated P2X receptor-channels have shed brighter light on the role of specific subtypes in the pathophysiology of chronic inflammatory, neuropathic or cancer pain...
July 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28726786/calcium-binding-protein-s100a14-induces-differentiation-and-suppresses-metastasis-in-gastric-cancer
#20
Min Zhu, Hongyi Wang, Jiantao Cui, Wenmei Li, Guo An, Yuanming Pan, Qingying Zhang, Rui Xing, Youyong Lu
S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors. In this study, we characterized the regulation of S100A14 expression between biological signatures and clinical pathological features in gastric cancer (GC). Our data demonstrated that S100A14 induced the differentiation of GC by upregulating the expression of E-cadherin and PGII. Moreover, S100A14 expression negatively correlated with cell migration and invasion in in vitro and in vivo experimental models...
July 20, 2017: Cell Death & Disease
keyword
keyword
59292
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"