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Pieter W J Lozekoot, Sandro Gelsomino, Paul B Kwant, Orlando Parise, Francesco Matteucci, Monique M J de Jong, Jos G Maessen, Paul F Gründeman
OBJECTIVE: Our aim was to evaluate a new inflatable lung retractor, the "Spacemaker", and its efficacy in facilitating minimally invasive cardiothoracic surgery without the need of one lung ventilation or carbon dioxide overpressure insufflation. METHODS: The device was tested in 12 anesthetized pigs (90-100 kg) placed on standard endotracheal ventilation. The device was introduced into the right or left side of the chest, depending on the intended procedure to be performed, via a 3-cm incision in the fifth intercostal space...
July 2015: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Dina S Coelho, Fatima Cairrão, Xiaomei Zeng, Elisabete Pires, Ana V Coelho, David Ron, Hyung Don Ryoo, Pedro M Domingos
The unfolded protein response (UPR) is composed by homeostatic signaling pathways that are activated by excessive protein misfolding in the endoplasmic reticulum. Ire1 signaling is an important mediator of the UPR, leading to the activation of the transcription factor Xbp1. Here, we show that Drosophila Ire1 mutant photoreceptors have defects in the delivery of rhodopsin-1 to the rhabdomere and in the secretion of Spacemaker/Eyes Shut into the interrhabdomeral space. However, these defects are not observed in Xbp1 mutant photoreceptors...
November 14, 2013: Cell Reports
Yukihiko Kinoshita, Hatsuhiko Maeda
Autogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the complicated three-dimensional structures in the craniomaxillofacial bone. The ultimate goal of craniomaxillofacial bone reconstruction is the regeneration of the physiological bone that simultaneously fulfills both morphological and functional restorations...
2013: TheScientificWorldJournal
L Di Battista, V D'Andrea, A Galani, F De Cristofaro, S Guarino, A Pulcini, M Nardi, A Maturo, S Palermo, E De Antoni, F Stio
INTRODUCTION: Subfascial Endoscopic Perforator Surgery (SEPS) enables the direct visualization and section of perforating veins. Morbidity and duration of hospitalization are both less than with conventional open surgery (Linton's or Felder's techniques). PATIENTS AND METHODS: A total of 322 legs from 285 patients with a mean age of 56 years (range 23-90) were treated at our Department from May 1996 to January 2010. In 309 cases, an endoscope (ETM Endoskopische Technik GmbH, Berlin, Germany) was introduced through a transverse incision approximately 1...
March 2012: Il Giornale di Chirurgia
Yukan Huang, Jing Zhang, Chang Li, Guohua Yang, Mugen Liu, Qing K Wang, Zhaohui Tang
BACKGROUND: Retinitis pigmentosa is the most important hereditary retinal degenerative disease, which has a high degree of clinical and genetic heterogeneity. More than half of all cases of retinitis pigmentosa are autosomal recessive (arRP), but the gene(s) causing arRP in most families has yet to be identified. The purpose of this study is to identify the genetic basis of severe arRP in a consanguineous Chinese family. METHODS: Linkage and haplotype analyses were used to define the chromosomal location of the pathogenic gene in the Chinese arRP family...
2010: BMC Medical Genetics
Rob W J Collin, Karin W Littink, B Jeroen Klevering, L Ingeborgh van den Born, Robert K Koenekoop, Marijke N Zonneveld, Ellen A W Blokland, Tim M Strom, Carel B Hoyng, Anneke I den Hollander, Frans P M Cremers
In patients with autosomal-recessive retinitis pigmentosa (arRP), homozygosity mapping was performed for detection of regions harboring genes that might be causative for RP. In one affected sib pair, a shared homozygous region of 5.0 Mb was identified on chromosome 6, within the RP25 locus. One of the genes residing in this interval was the retina-expressed gene EGFL11. Several genes resembling EGFL11 were predicted just centromeric of EGFL11. Extensive long-range RT-PCR, combined with 5'- and 3'- RACE analysis, resulted in the identification of a 10-kb transcript, starting with the annotated exons of EGFL11 and spanning 44 exons and 2 Mb of genomic DNA...
November 2008: American Journal of Human Genetics
Mai M Abd El-Aziz, Isabel Barragan, Ciara A O'Driscoll, Leo Goodstadt, Elena Prigmore, Salud Borrego, Marcela Mena, Juan I Pieras, Mohamed F El-Ashry, Leen Abu Safieh, Amna Shah, Michael E Cheetham, Nigel P Carter, Christina Chakarova, Chris P Ponting, Shomi S Bhattacharya, Guillermo Antinolo
Using a positional cloning approach supported by comparative genomics, we have identified a previously unreported gene, EYS, at the RP25 locus on chromosome 6q12 commonly mutated in autosomal recessive retinitis pigmentosa. Spanning over 2 Mb, this is the largest eye-specific gene identified so far. EYS is independently disrupted in four other mammalian lineages, including that of rodents, but is well conserved from Drosophila to man and is likely to have a role in the modeling of retinal architecture.
November 2008: Nature Genetics
Sang-Hoon Park, Hom-Lay Wang
This case series presents the use of acellular dermal matrix (ADM) as a barrier membrane in reconstructing non-spacemaking buccal dehiscences associated with simultaneous implant placement in locally deficient ridges. Five sites in four healthy nonsmoking patients were treated with a combination of the mucogingival pouch flap technique, sandwiched layering of mineralized human cancellous and cortical bone grafts, and ADM as a barrier membrane. Three sites encountered 2 to 4 mm of membrane exposure after 2 weeks of healing time...
December 2006: International Journal of Periodontics & Restorative Dentistry
Daniel Osorio
The open rhabdoms of the fly's eye enhance absolute sensitivity but to avoid compromising spatial acuity they require precise optical geometry and neural connections.1 This neural superposition system evolved from the ancestral insect eye, which has fused rhabdoms. A recent paper by Zelhof and co-workers shows that the Drosophila gene spacemaker (spam) is necessary for development of open rhabdoms, and suggests that mutants revert to an ancestral state. Here I outline how open rhabdoms and neural superposition may have evolved via nocturnal intermediates, and discuss the implications for the role of spam in insect phylogeny...
February 2007: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
Andrew C Zelhof, Robert W Hardy, Ann Becker, Charles S Zuker
Eyes differ markedly in the animal kingdom, and are an extreme example of the evolution of multiple anatomical solutions to light detection and image formation. A salient feature of all photoreceptor cells is the presence of a specialized compartment (disc outer segments in vertebrates, and microvillar rhabdomeres in insects), whose primary role is to accommodate the millions of light receptor molecules required for efficient photon collection. In insects, compound eyes can have very different inner architectures...
October 12, 2006: Nature
Abraham Amir, Ram Silfen, Daniel J Hauben
Most of the techniques that have been suggested for closure of sacral pressure sores use musculo-cutaneous flaps. We report our experience in three patients using the SpaceMaker balloon dissector. The dissector was inserted into the subgluteal maximus muscle plane to expand the muscle and overlying skin, thereby forming bilateral sliding and tension-free musculocutaneous flaps. The procedure is simple, safe, bloodless, and combines the advantages of advancement of a muscle flap and expansion.
2004: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Galit Shor, Dan Regev, Abraham Amir, Marissa Halperin, Shamai Giler, Daniel J Hauben
The pectoralis major advancement flap is currently the most popular technique for reconstruction of the anterior chest in patients with sternotomy wounds. Recently, the SpaceMaker balloon was introduced for rapid expansion of the pectoralis major muscle intraoperatively. The aim of the present study was to investigate the biomechanical and histologic effects of this expansion technique in a rat model. The upper 2 cm of the sternum was resected in 54 male rats. Reconstruction with balloon-assisted pectoralis muscle expansion was performed in 24 rats (study group)...
March 2004: Plastic and Reconstructive Surgery
D J Hauben, O Shulman, Y Levi, J Sulkes, A Amir, R Silfen
Sternal wound infection is surgically treated by debridement of the infected sternum and closure of the defect with a muscular flap. These operations tend to be long, stressful, and time-consuming and to involve heavy blood loss. To facilitate wound closure, the SpaceMaker balloon was applied intraoperatively to expand the pectoralis major muscles and enable tensionless closure with musculocutaneous flaps. The aim of the present study was to compare the effectiveness and feasibility of this technique with a variety of others described in the literature...
November 2001: Plastic and Reconstructive Surgery
E Milella, P A Ramires, E Brescia, G La Sala, L Di Paola, V Bruno
Barrier membranes for guided tissue regeneration (GTR) to treat bone defects have to satisfy criteria of biocompatibility, cell-occlusiveness, spacemaking, tissue integration, and clinical manageability. In this study, the morphological and mechanical properties of two commercial biodegradable membranes (Resolut LT and Biofix) as a function of the incubation time have been compared. Moreover, their permeability to both fluids and epithelial cells as well as the bacteria adhesion have been evaluated. The membranes are asymmetric and composed of a dense polymeric layer coupled with nonwoven (Resolut LT) or woven (Biofix) fibers...
2001: Journal of Biomedical Materials Research
D B Jones, M A Quasebarth, L M Brunt
Applications of minimally invasive surgery have evolved from laparoscopic cholecystectomy and spread beyond conventional body cavities to new applications and disease processes. The purpose of the present study was to evaluate the feasibility of performing videoendoscopic thyroidectomy in a canine model. Adult mongrel dogs served as the experimental model for this study. The pretracheal space was entered via a 2.5-cm midline neck incision superior to the sternal notch and then expanded with a balloon spacemaker...
June 1999: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
C Tinti, S Parma-Benfenati, F Manfrini
This article presents a surgical technique to promote bone regeneration and enlargement of localized alveolar ridge defects in the mandible. The purpose of this study was to investigate the use of spacemaking gold frames used in combination with expanded polytetrafluoroethylene Gore-Tex augmentation membranes (WL Gore) on two patients to create and maintain adequate space for the regeneration of bone. The membrane was sutured under the frame and the assembly was bent and adapted over the residual bony defect to create a dome and prevent the expanded polytetrafluoroethylene barrier membranes from collapsing into the defects...
February 1997: International Journal of Periodontics & Restorative Dentistry
J T Mellonig, M Nevins, R Sanchez
Part I of the evaluation of a prototype bioabsorbable physical barrier composed of a copolymer of lactide and glycolide for treatment of bone defects in the guided bone regeneration procedure indicated that the prototype bioabsorbable physical barrier did not possess sufficient spacemaking characteristics to prevent collapse of the barrier into the defect or against the threads of the titanium implants. The purpose of Part II was to evaluate this bioabsorbable physical barrier in combination with a supporting material to prevent barrier collapse...
April 1998: International Journal of Periodontics & Restorative Dentistry
G Santarelli, R Parodi, G Carusi
This paper presents a case in which a resorbable collagen membrane and a collagen-based spacemaker and root surface conditioning were used in a guided tissue regeneration procedure. There was no need to disturb the healing potential of the underlying selected cells with an early reentry procedure. Clinical postoperative findings at the time of surgery and in an 18-month follow-up and the differences in density of the mineralized tissues, as detected by standardized series of juxtagingival radiographs and during surgical reentry, showed encouraging results in bone regeneration and soft tissue management...
February 1996: International Journal of Periodontics & Restorative Dentistry
J T Mellonig, M Nevins
Guided bone regeneration is a new technique that evolved following the guided tissue regeneration procedure for regeneration of lost periodontium. The objective of guided bone regeneration is to promote bone formation in osseous deformities either before or in conjunction with endosseous implant placement. Osseous defects consist mainly of extraction sites, dehiscences or fenestrations, and localized ridge deformities. In addition, bone defects may either provide natural spacemaking or be nonspacemaking. A plethora of publications indicate that the guided bone regeneration technique can be used successfully in all types of defects...
April 1995: International Journal of Periodontics & Restorative Dentistry
T V Scantlebury
In the last decade guided tissue regeneration (GTR) therapy has evolved in both surgical technique and membrane technology. Given new applications and membrane materials, not only must new surgical techniques be critiqued, but membrane designs must be critically examined as well. A review of historical membrane development suggests that 5 design criteria are essential: 1) tissue integration; 2) cell-occlusivity; 3) clinical manageability; 4) spacemaking; and 5) biocompatibility. These criteria may be applied to select appropriate materials and designs for specific GTR applications...
November 1993: Journal of Periodontology
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