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https://www.readbyqxmd.com/read/29329555/exercise-during-and-after-neoadjuvant-rectal-cancer-treatment-the-exert-trial-study-protocol-for-a-randomized-controlled-trial
#1
Andria R Morielli, Nawaid Usmani, Normand G Boulé, Diane Severin, Keith Tankel, Tirath Nijjar, Kurian Joseph, Alysa Fairchild, Kerry S Courneya
BACKGROUND: Standard treatment for locally advanced rectal cancer includes 5-6 weeks of neoadjuvant chemoradiotherapy (NACRT) followed by total mesorectal excision 6-8 weeks later. NACRT improves local disease control and surgical outcomes but also causes side effects including fatigue, diarrhea, hand-foot syndrome, and physical deconditioning that may impede quality of life (QoL), treatment completion, treatment response, and long-term prognosis. Interventions to improve treatment outcomes and manage side effects that are safe, tolerable and low-cost are highly desirable...
January 12, 2018: Trials
https://www.readbyqxmd.com/read/29327605/does-change-in-isolated-lumbar-extensor-muscle-function-correlate-with-good-clinical-outcome-a-secondary-analysis-of-data-on-change-in-isolated-lumbar-extension-strength-pain-and-disability-in-chronic-low-back-pain
#2
James Steele, James Fisher, Craig Perrin, Rebecca Conway, Stewart Bruce-Low, Dave Smith
PURPOSE: Secondary analysis of data from studies utilising isolated lumbar extension exercise interventions for correlations among changes in isolated lumbar extension strength, pain, and disability. MATERIALS AND METHODS: Studies reporting isolated lumbar extension strength changes were examined for inclusion criteria including: (1) participants with chronic low back pain, (2) intervention ≥ four weeks including isolated lumbar extension exercise, (3) outcome measures including isolated lumbar extension strength, pain (Visual Analogue Scale), and disability (Oswestry Disability Index)...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29286534/fitness-training-for-cardiorespiratory-conditioning-after-traumatic-brain-injury
#3
REVIEW
Leanne Hassett, Anne M Moseley, Alison R Harmer
BACKGROUND: Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. OBJECTIVES: The primary objective of this updated review was to evaluate whether fitness training improves cardiorespiratory fitness in people who have sustained a TBI. The secondary objectives were to evaluate whether fitness training improves body function and structure (physical and cognitive impairments, psychological responses resulting from the injury), activity limitations and participation restrictions in people who have sustained a TBI as well as to evaluate its safety, acceptance, feasibility and suitability...
December 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29248005/short-term-disuse-promotes-fatty-acid-infiltration-into-skeletal-muscle
#4
Allan F Pagano, Thomas Brioche, Coralie Arc-Chagnaud, Rémi Demangel, Angèle Chopard, Guillaume Py
BACKGROUND: Many physiological and/or pathological conditions lead to muscle deconditioning, a well-described phenomenon characterized by a loss of strength and muscle power mainly due to the loss of muscle mass. Fatty infiltrations, or intermuscular adipose tissue (IMAT), are currently well-recognized components of muscle deconditioning. Despite the fact that IMAT is present in healthy human skeletal muscle, its increase and accumulation are linked to muscle dysfunction. Although IMAT development has been largely attributable to inactivity, the precise mechanisms of its establishment are still poorly understood...
December 16, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29244254/effect-of-deconditioning-on-cortical-and-cancellous-bone-growth-in-the-exercise-trained-young-rats
#5
Jun Iwamoto, James K Yeh, John F Aloia
No abstract text is available yet for this article.
December 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29233245/occupational-specific-strength-predicts-astronaut-related-task-performance-in-a-weighted-suit
#6
Andrew Taylor, Christopher J Kotarsky, Colin W Bond, Kyle J Hackney
BACKGROUND: Future space missions beyond low Earth orbit will require deconditioned astronauts to perform occupationally relevant tasks within a planetary spacesuit. The prediction of time-to-completion (TTC) of astronaut tasks will be critical for crew safety, autonomous operations, and mission success. This exploratory study determined if the addition of task-specific strength testing to current standard lower body testing would enhance the prediction of TTC in a 1-G test battery. METHODS: Eight healthy participants completed NASA lower body strength tests, occupationally specific strength tests, and performed six task simulations (hand drilling, construction wrenching, incline walking, collecting weighted samples, and dragging an unresponsive crewmember to safety) in a 48-kg weighted suit...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29222399/pediatric-disorders-of-orthostatic-intolerance
#7
REVIEW
Julian M Stewart, Jeffrey R Boris, Gisela Chelimsky, Phillip R Fischer, John E Fortunato, Blair P Grubb, Geoffrey L Heyer, Imad T Jarjour, Marvin S Medow, Mohammed T Numan, Paolo T Pianosi, Wolfgang Singer, Sally Tarbell, Thomas C Chelimsky
Orthostatic intolerance (OI), having difficulty tolerating an upright posture because of symptoms or signs that abate when returned to supine, is common in pediatrics. For example, ∼40% of people faint during their lives, half of whom faint during adolescence, and the peak age for first faint is 15 years. Because of this, we describe the most common forms of OI in pediatrics and distinguish between chronic and acute OI. These common forms of OI include initial orthostatic hypotension (which is a frequently seen benign condition in youngsters), true orthostatic hypotension (both neurogenic and nonneurogenic), vasovagal syncope, and postural tachycardia syndrome...
January 2018: Pediatrics
https://www.readbyqxmd.com/read/29212669/long-duration-bed-rest-modifies-sympathetic-neural-recruitment-strategies-in-males-and-females
#8
Stephen A Klassen, Steven De Abreu, Danielle K Greaves, Derek S Kimmerly, Philippe Arbeille, Pierre Denise, Richard L Hughson, Hervé Normand, J Kevin Shoemaker
To understand the impact of physical deconditioning with head-down tilt bed rest (HDBR) on the malleability of sympathetic discharge patterns, we studied a) baseline integrated muscle sympathetic nerve activity (MSNA; microneurography) from 13 females participating in the WISE-2005 60-day HDBR study (Female, retrospective analysis), b) integrated MSNA and multi-unit action potential (AP) analysis in 13 males (Male) performed on data collected at baseline and during physiological stress imposed by end-inspiratory apnea, in a new 60-day HDBR study, and c) a repeatability study (Control, n = 6, retrospective analysis, 4 weeks between tests)...
December 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29210749/pulmonary-rehabilitation-for-patients-with-acute-chronic-obstructive-pulmonary-disease-exacerbations-is-the-evidence-strengthening
#9
Lissa Spencer
PURPOSE OF REVIEW: This manuscript aims to review the most recent evidence about the benefits of early pulmonary rehabilitation commenced during an acute exacerbation in people with COPD (AECOPD). RECENT FINDINGS: A number of RCTs and an observational study, published between 2015 and 2017, have used different exercise interventions compared with usual medical care in people with moderate-to-severe COPD during an AECOPD. The results show short-term improvement in walking distance, muscle strength, quality of life and anxiety and depression...
November 27, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29188878/effect-of-a-6-month-brisk-walking-program-on-walking-endurance-in-sedentary-and-physically-deconditioned-women-aged-60-or-older-a-randomized-trial
#10
H Blain, A Jaussent, M-C Picot, L Maimoun, O Coste, T Masud, J Bousquet, P L Bernard
BACKGROUND: Walking endurance is a predictor of healthy ageing. OBJECTIVE: To examine if a 6-month brisk walking program can increase walking endurance in sedentary and physically deconditioned older women. TRIAL DESIGN: Randomized controlled trial. SETTING: Women recruited from public meetings aimed at promoting physical activity in women aged 60 or older. SUBJECTS: 121 women aged 65.7 ± 4.3 years, with sedentary lifestyle (Physical Activity Questionnaire for the Elderly score < 9...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29174408/survivorship-and-outcomes-in-patients-with-multiple-sclerosis-undergoing-total-joint-arthroplasty
#11
Alexander J Rondon, Patrick K Schlitt, Timothy L Tan, Jessica L Phillips, Max R Greenky, James J Purtill
BACKGROUND: Patients with multiple sclerosis (MS) frequently require total joint arthroplasty (TJA). The outcomes of TJA in patients with MS, who are frequently on immunomodulatory medications and physically deconditioned, remain largely unknown. The aim of this study is to elucidate the survivorship and reasons for failure in this patient population. METHODS: A single-institution retrospective review of 108 TJAs (46 knees and 62 hips) was performed from 2000 to 2016...
November 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#12
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29151096/jumping-frenchmen-miryachit-and-latah-culture-specific-hyperstartle-plus-syndromes
#13
Douglas J Lanska
In the late 19th century, jumping (French Canadians in Maine, USA), miryachit (Siberia), and latah (Southeast Asia) were among a group of similar disorders described around the world, each of which manifests as an exaggerated startle response with additional late-response features that were felt by some to overlap with hysteria or tics. The later features following the exaggerated startle reaction variably include mimesis (e.g., echopraxia, echolalia) and automatic obedience. These reaction patterns tended to persist indefinitely in affected individuals...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29141926/ectopic-acth-syndrome-complicated-by-multiple-opportunistic-infections-treated-with-percutaneous-ablation-of-the-adrenal-glands
#14
Chrystal Chan, James Mark Roberts
Ectopic adrenocorticotropic hormone (ACTH)-related Cushing's syndrome can lead to multiple complications including severe immunosuppression. If the ACTH-secreting tumour cannot be found, definitive treatment is surgical adrenalectomy, typically followed by glucocorticoid replacement. Here, we present a case of fulminant respiratory failure secondary to coinfection with Pneumocystis jirovecii and cytomegalovirus in a patient with ectopic ACTH-dependent Cushing's syndrome with occult primary. Due to significant deconditioning, she was unable to undergo definitive adrenalectomy and instead underwent percutaneous microwave ablation of the adrenal glands...
November 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29134470/the-effect-of-long-term-confinement-and-the-efficacy-of-exercise-countermeasures-on-muscle-strength-during-a-simulated-mission-to-mars-data-from-the-mars500-study
#15
Christopher J Gaffney, Elena Fomina, Dennis Babich, Vladimir Kitov, Konstantin Uskov, David A Green
BACKGROUND: Isolation and long duration spaceflight are associated with musculoskeletal deconditioning. Mars500 was a unique, high-fidelity analogue of the psychological challenges of a 520-day manned mission to Mars. We aimed to explore the effect of musculoskeletal deconditioning on three outcome measures: (1) if lower limb muscle strength was reduced during the 520-day isolation; (2) if type I or II muscle fibres were differentially affected; and (3) whether any 70-day exercise interventions prevented any isolation-induced loss of strength...
November 13, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/29110977/clinical-mimics-an-emergency-medicine-focused-review-of-syncope-mimics
#16
Diana K Coleman, Brit Long, Alex Koyfman
BACKGROUND: Syncope is an event that causes a transient loss of consciousness (LOC) secondary to global cerebral hypoperfusion. The transient nature of the event can make diagnosis in the emergency department (ED) difficult, as symptoms have often resolved by time of initial presentation. The symptoms and presentation of syncope are similar to many other conditions, which can lead to difficulty in establishing a diagnosis in the ED. OBJECTIVE: This review evaluates patients presenting with a history concerning for possible syncope, mimics of syncope, and approach to managing syncope mimics...
October 27, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29098918/exercise-and-quality-of-life-after-first-ever-ischaemic-stroke-a-two-year-follow-up-study
#17
Lisha Hou, Xudong Du, Longmei Chen, Jijie Li, Peijing Yan, Muke Zhou, Cairong Zhu
BACKGROUND: Quality of life (QoL) post-stroke is an important health outcome. Physical deconditioning and physical inactivity are highly prevalent in stroke survivors. This study aimed to assess the long-term trends in QoL and to explore the effect of exercise on the QoL of ischaemic stroke patients. METHODS: Data for this prospective study were collected at baseline using face-to-face interviews, and telephone follow-ups were completed every 3 months from 2010 through 2014...
November 3, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29081752/multi-system-deconditioning-in-3-day-dry-immersion-without-daily-raise
#18
Steven De Abreu, Liubov Amirova, Ronan Murphy, Robert Wallace, Laura Twomey, Guillemette Gauquelin-Koch, Veronique Raverot, Françoise Larcher, Marc-Antoine Custaud, Nastassia Navasiolava
Dry immersion (DI) is a Russian-developed, ground-based model to study the physiological effects of microgravity. It accurately reproduces environmental conditions of weightlessness, such as enhanced physical inactivity, suppression of hydrostatic pressure and supportlessness. We aimed to study the integrative physiological responses to a 3-day strict DI protocol in 12 healthy men, and to assess the extent of multi-system deconditioning. We recorded general clinical data, biological data and evaluated body fluid changes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29076058/pharmacotherapy-of-cardiovascular-autonomic-dysfunction-in-parkinson-disease
#19
REVIEW
Cyndya A Shibao, Horacio Kaufmann
Cardiovascular autonomic dysfunctions, including neurogenic orthostatic hypotension, supine hypertension and post-prandial hypotension, are relatively common in patients with Parkinson disease. Recent evidence suggests that early autonomic impairment such as cardiac autonomic denervation and even neurogenic orthostatic hypotension occur prior to the appearance of the typical motor deficits associated with the disease. When neurogenic orthostatic hypotension develops, patients with Parkinson disease have an increased risk of mortality, falls, and trauma-related to falls...
October 26, 2017: CNS Drugs
https://www.readbyqxmd.com/read/29075195/falls-and-fall-prevention-in-older-persons-geriatrics-meets-spaceflight
#20
REVIEW
Nandu Goswami
This paper provides a general overview of key physiological consequences of microgravity experienced during spaceflight and of important parallels and connections to the physiology of aging. Microgravity during spaceflight influences cardiovascular function, cerebral autoregulation, musculoskeletal, and sensorimotor system performance. A great deal of research has been carried out to understand these influences and to provide countermeasures to reduce the observed negative consequences of microgravity on physiological function...
2017: Frontiers in Physiology
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