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https://www.readbyqxmd.com/read/28544073/hydrophilic-interaction-and-reversed-phase-ultra-performance-liquid-chromatography-tof-ms-for-metabolomic-analysis-of-veratrum-nigrum-induced-cardiotoxicity
#1
Ziheng Wei, Xu Dong, Hanzhe Zhang, Songyan Gao, Wei Shi, Feng Yang, Xin Dong
The acute cardiotoxicity induced by Veratrum nigrum (VN) is explored by analysing heart tissue metabolic profiles in mouse models and applying reversed-phase liquid chromatography mass spectrometry (RPLC-MS) and hydrophilic interaction liquid chromatography mass spectrometry (HILIC-MS) that are based on ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). An animal model of acute heart injury was established in mice via intra-gastric administration of VN. Then, electrocardiogram, echocardiograph monitoring of cardiac function and pathological examination were performed on mice both in the control and VN groups, and it was successfully verified that acute heart injury was caused...
May 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28541451/uplc-q-tof-ms-based-metabolic-profiling-comparison-of-two-major-bioactive-components-and-their-metabolites-in-normal-and-ckd-rat-plasma-urine-and-feces-following-oral-administration-of-fructus-corni-extract
#2
Min Zhao, Jinhua Tao, Leyue Du, Shu Jiang, Dawei Qian, Jinao Duan
Fructus Corni has been used for nourishing liver and kidney in clinical practice for many years. However, the in vivo integrated metabolism profile of its bioactive components remains unknown. In the present study, ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry coupled with the MetaboLynxTM software was established for screening and identification of the metabolites of the loganin and the morroniside in normal and chronic kidney disease (CKD) rat plasma, urine and feces after oral administration of Fructus Corni extract...
May 24, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28537816/effect-of-vitamin-e-and-polyunsaturated-fatty-acids-on-cryopreserved-sperm-quality-in-bos-taurus-bulls-under-testicular-heat-stress
#3
João D A Losano, Daniel S R Angrimani, Andressa Dalmazzo, Carolina C Rocha, Maíra M Brito, Eduardo G A Perez, Roberta H Tsunoda, Paola A A Góes, Camilla M Mendes, Mayra E O A Assumpção, Valquiria H Barnabe, Marcilio Nichi
Taurine bulls are highly susceptible to heat stress, leading to increased oxidative stress (OS) and impaired sperm viability. Polyunsaturated fatty acids (PUFAs) supplementation can be an alternative to improve semen quality, which also results in more sperm susceptibility to lipid peroxidation. Moreover, this deleterious effect can be exacerbated in animals affected by heat stress. Vitamin E is a key antioxidant that counteracts lipid peroxidation of sperm membrane caused by OS. Thus, combining PUFAs with vitamin E may improve sperm quality...
May 24, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28536755/taurine-protects-cardiac-contractility-in-killifish-fundulus-heteroclitus-by-enhancing-sarcoplasmic-reticular-ca-2-cycling
#4
Elenor F Henry, Tyson J MacCormack
Intracellular taurine is abundant in many animals and it influences an array of physiological processes, including osmoregulation, metabolism, and cardiac contractility. Taurine is an important osmolyte in teleost hearts, but its role in stress tolerance, cardiac metabolism, and contractility has not been assessed. The goal of this study was to determine if ventricular taurine concentration changes in response to environmental stress and to characterize its influence on contractility. Cardiac taurine concentrations varied in killifish (Fundulus heteroclitus) but were generally maintained following acute environmental challenges...
May 23, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28535055/ionic-liquid-anion-controlled-nanoscale-gold-morphology-grown-at-a-liquid-interface
#5
Nakara Bhawawet, Jeremy B Essner, Durgesh Vinod Wagle, Gary A Baker
Two different ionic liquids comprising the tetrabutylphosphonium cation ([P4444]) paired with the strongly-coordinating anions 6-aminocaproate ([6-AC]) or taurinate ([tau]) were prepared and employed in an aqueous/organic liquid bilayer system to generate nanoscale gold by Au(OH)4- photoreduction. Generally, as the concentration of ionic liquid in the organic phase was increased, the resulting quasi-spherical gold nanoparticles reduced in size and presented less aggregation, leading to marked increases in the catalytic efficiency for 4-nitrophenol reduction using borohydride...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28524186/taurine-modified-ru-ii-complex-targets-cancerous-brain-cells-for-photodynamic-therapy
#6
Enming Du, Xunwu Hu, Sona Roy, Peng Wang, Kieran Deasy, Toshiaki Mochizuki, Ye Zhang
The precision and efficacy of photodynamic therapy (PDT) is essential for the treatment of brain tumors because the cancer cells are within or adjacent to the delicate nervous system. Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS). A taurine-modified polypyridyl Ru-complex was shown to have optimized intracellular affinity in cancer cells through accumulation in lysosomes. Symmetrical modification of this Ru-complex by multiple taurine molecules enhanced the efficiency of molecular emission with boosted generation of reactive oxygen species...
May 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28523277/the-effect-of-l-carnitine-hypotaurine-and-taurine-supplementation-on-the-quality-of-cryopreserved-chicken-semen
#7
Agnieszka Partyka, Olga Rodak, Joanna Bajzert, Joanna Kochan, Wojciech Niżański
The objective of this study was to investigate the effect of L-carnitine (LC), hypotaurine (HT), and taurine (T) on the quality of frozen-thawed chicken semen. Pooled semen samples were divided into seven aliquots (control, 1 mM LC, 5 mM LC, 1 mM HT, 10 mM HT, 1 mM T, and 10 mM T) and subjected to cryopreservation. Postthaw sperm motility was determined by IVOS system and sperm characteristics were assessed with fluorochromes and flow cytometry. The highest sperm motility and the highest percentage of viable sperm were in the HT1 group (P < 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28511341/in-vivo-and-molecular-docking-studies-using-whole-extract-and-phytocompounds-of-aegle-marmelos-fruit-protective-effects-against-isoproterenol-induced-myocardial-infarction-in-rats
#8
Gadamsetty Saayi Krushna, Vutharadhi Leela Shivaranjani, Jolapuram Umamaheswari, Cheemanapalli Srinivasulu, Shaik Althaf Hussain, Mohammed Abdul Kareem, Vaddi Damodara Reddy, Daoud Ali, Kiran Bharat Lokhande, K Venkateswara Swamy, Lakshmi Devi Kodidhela
Myocardial infarction (MI) is a leading major health problem with increased morbidity and mortality worldwide. The present study investigates isoproterenol (ISO) induced MI and the beneficial role of Aegle marmelos fruit extract (AMFE) in rats. Our results indicated the significant augmentation of plasma nitric oxide (NOx) levels, C-reactive protein (CRP), homocysteine, apolipoprotein B (apo-B), cardiac tissue lipid peroxidation and liver 3-hydroxy-3 methyl glutaryl CoA (HMG-CoA) reductase activity in ISO treated rats (85mg/kg b...
May 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28507750/effects-of-conventional-and-a-novel-colonic-release-bile-acid-sequestrant-a3384-on-fibroblast-growth-factor-19-and-bile-acid-metabolism-in-healthy-volunteers-and-patients-with-bile-acid-diarrhoea
#9
R N Appleby, A Bajor, P-G Gillberg, H Graffner, M Simrén, K A Ung, Jrf Walters
BACKGROUND: Primary bile acid diarrhoea (BAD) is associated with increased bile acid synthesis and low fibroblast growth factor 19 (FGF19). Bile acid sequestrants are used as therapy, but are poorly tolerated and may exacerbate FGF19 deficiency. AIM: The purpose of this study was to evaluate the pharmacological effects of conventional sequestrants and a colonic-release formulation preparation of colestyramine (A3384) on bile acid metabolism and bowel function in patients with BAD...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28505527/amino-acid-and-acetylcholine-chemistry-in-the-central-auditory-system-of-young-middle-aged-and-old-rats
#10
Donald A Godfrey, Kejian Chen, Thomas R O'Toole, Abdurrahman I A A Mustapha
Older adults generally experience difficulties with hearing. Age-related changes in the chemistry of central auditory regions, especially the chemistry underlying synaptic transmission between neurons, may be of particular relevance for hearing changes. In this study, we used quantitative microchemical methods to map concentrations of amino acids, including the major neurotransmitters of the brain, in all the major central auditory structures of young (6 months), middle-aged (22 months), and old (33 months old) Fischer 344 x Brown Norway rats...
May 4, 2017: Hearing Research
https://www.readbyqxmd.com/read/28503069/downregulation-of-long-noncoding-rna-tug1-inhibits-proliferation-and-induces-apoptosis-through-the-tug1-mir-142-zeb2-axis-in-bladder-cancer-cells
#11
Qian Liu, Hui Liu, Hepeng Cheng, Yang Li, Xiaodong Li, Chaoyang Zhu
BACKGROUND: Bladder cancer is a common serious disease around the world. Long noncoding RNAs (lncRNAs) have been demonstrated to participate in the development and progression of various cancers, including bladder cancer. The aim of this study was to investigate the effects of lncRNA taurine upregulated gene 1 (TUG1) on proliferation and apoptosis in bladder cancer cell lines and the underlying mechanism. METHODS: The levels of TUG1 were detected by quantitative real time polymerase chain reaction (qRT-PCR) in bladder cancer tissues and cells...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28497479/proximate-composition-amino-acid-and-fatty-acid-profiles-of-marine-snail-rapana-venosa-meat-visceral-mass-and-operculum
#12
Fenglei Luo, Ronge Xing, Xueqin Wang, Quancai Peng, Pengcheng Li
BACKGROUND: Rapana venosa (Rv), an important marine snail, presents increasing nutritional, and economic importance. However, there still has been limited information on their nutritional composition. This study highlighted and provided new information on the proximate composition, amino acids and fatty acids profiles of Rv different body parts in order to its better application and research. RESULTS: The operculum contained high amount of protein and flavor amino acids...
May 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28496104/gender-differences-in-bile-acids-and-microbiota-in-relationship-with-gender-dissimilarity-in-steatosis-induced-by-diet-and-fxr-inactivation
#13
Lili Sheng, Prasant Kumar Jena, Hui-Xin Liu, Karen M Kalanetra, Frank J Gonzalez, Samuel W French, Viswanathan V Krishnan, David A Mills, Yu-Jui Yvonne Wan
This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders. A control diet (CD) and Western diet (WD), which contains high fat and carbohydrate, were used to feed wild type (WT) and FXR knockout (KO) mice followed by phenotyping characterization as well as BA and microbiota profiling. Our data revealed that male WD-fed FXR KO mice had the most severe steatosis and highest hepatic and serum lipids as well as insulin resistance among the eight studied groups...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490352/a-diagnostic-biomarker-profile-for-fibromyalgia-syndrome-based-on-an-nmr-metabolomics-study-of-selected-patients-and-controls
#14
Bontle G Malatji, Helgard Meyer, Shayne Mason, Udo F H Engelke, Ron A Wevers, Mari van Reenen, Carolus J Reinecke
BACKGROUND: Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a continuing endeavour in FMS research. Our objective was to perform an explorative metabolomics study (1) to elucidate the global urinary metabolite profile of patients suffering from FMS, and (2) to explore the potential of this metabolite information to augment existing medical practice in diagnosing the disease...
May 11, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28490178/atom-tunneling-in-the-hydroxylation-process-of-taurine-%C3%AE-ketoglutarate-dioxygenase-taud-identified-by-qm-mm-simulations
#15
Sonia Álvarez-Barcia, Johannes Kästner
TauD dioxygenase is one of the most studied α-ketoglutarate dependent dioxygenases (αKGDs), involved in several biotechnological applications. We investigated the key step in the catalytic cycle of the αKGDs, the hydrogen transfer process, by a QM/MM approach (B3LYP/CHARMM22). Analysis of the charge and spin densities during the reaction demonstrates that a concerted mechanism takes place, where the H atom transfer happens simultaneously with the electron transfer from taurine to the Fe=O cofactor. We found quantum tunneling of the hydrogen atom to increase the rate constant by a factor of 40 at 5 °C...
May 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28485791/the-protective-effects-of-taurine-on-experimental-autoimmune-myocarditis
#16
Y-F Lu, Q-Y Zhang, L-H Wang, X-Y Liu, S-X Zhang
OBJECTIVE: To investigate the protective effects of taurine on experimental autoimmune myocarditis and its mechanisms. BALB/c mice were immunized with porcine cardiac myosin to induce experimental autoimmune myocarditis (EAM). MATERIALS AND METHODS: We administered taurine (5 mg/kg, 10 mg/kg or 20 mg/kg) or vehicle to EAM mice daily. On day 21, the severity of myocarditis was evaluated by determination of heart weight/body weight ratio (Hw/Bw), histopathological and echocardiographic examination of heart tissue...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485789/efficacy-of-a-combination-of-taurine-and-stenosis-removing-on-cognitive-impairment-induced-by-carotid-artery-stenosis-in-rats
#17
X-Z Liu, F-C Wang, Y Wang, J-X Zhang
OBJECTIVE: We assessed the protective effect on a carotid artery stenosis rat model with using a combination of taurine and stenosis treatment. Rats were randomly divided into five groups: Group 1 (sham), Group 2 (model), Group 3 (stenosis removing), Group 4 (taurine), and Group 5 (combination). MATERIALS AND METHODS: The carotid artery stenosis model was created by ligating the common carotid artery along with various gauges of needle and then removing the needle...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28471355/structure-of-nadp-bound-7%C3%AE-hydroxysteroid-dehydrogenase-reveals-two-cofactor-binding-modes
#18
Rui Wang, Jiaquan Wu, David Kin Jin, Yali Chen, Zhijia Lv, Qian Chen, Qiwei Miao, Xiaoyu Huo, Feng Wang
In mammals, bile acids/salts and their glycine and taurine conjugates are effectively recycled through enterohepatic circulation. 7β-Hydroxysteroid dehydrogenases (7β-HSDHs; EC 1.1.1.201), including that from the intestinal microbe Collinsella aerofaciens, catalyse the NADPH-dependent reversible oxidation of secondary bile-acid products to avoid potential toxicity. Here, the first structure of NADP(+) bound to dimeric 7β-HSDH is presented. In one active site, NADP(+) adopts a conventional binding mode similar to that displayed in related enzyme structures...
May 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28469184/simultaneous-quantification-of-amino-metabolites-in-multiple-metabolic-pathways-using-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#19
Jin Wang, Lihong Zhou, Hehua Lei, Fuhua Hao, Xin Liu, Yulan Wang, Huiru Tang
Metabolites containing amino groups cover multiple pathways and play important roles in redox homeostasis and biosyntheses of proteins, nucleotides and neurotransmitters. Here, we report a new method for simultaneous quantification of 124 such metabolites. This is achieved by derivatization-assisted sensitivity enhancement with 5-aminoisoquinolyl-N-hydroxysuccinimidyl carbamate (5-AIQC) followed with comprehensive analysis using ultra-high performance liquid chromatography and electrospray ionization tandem mass spectrometry (UHPLC-MS/MS)...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28466821/long-non-codingrna-lncrna-tug1-and-the-prognosis-of-cancer-a-meta-analysis
#20
X-H Yu, W Guo, J Zhang, C Ma, A-J Chu, B-L Wen, X Zhang, X-Y Yan, C-M Wu, D-M Wang, Y-L Qu
Some studies assessed the association between lncRNA taurine-upregulated gene 1 (TUG1) and the survival in cancer. However, the results were inconclusive.  Therefore, we performed a meta-analysis to determine this association. We used the following electronic databases to search for eligible literature: PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. We used ORs and 95% CIs to measure the association between TUG1 and the survival of cancer. There was no significant association between TUG1 and OS of cancer (HR=1...
March 31, 2017: Cellular and Molecular Biology
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