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https://www.readbyqxmd.com/read/29778932/dynamics-of-paralytic-shellfish-toxins-and-their-metabolites-during-timecourse-exposure-of-scallops-chlamys-farreri-and-mussels-mytilus-galloprovincialis-to-alexandrium-pacificum
#1
Jiangbing Qiu, Fanping Meng, Ling Ding, Yijia Che, Pearse McCarron, Daniel G Beach, Aifeng Li
New C-11 hydroxyl metabolites of paralytic shellfish toxins (PSTs) have been reported in shellfish. To gain further information on these metabolites, as well as the potential for formation of phase-II metabolites and acyl esters of PSTs, bivalves were fed with the PSTs-producing dinoflagellate Alexandrium pacificum (strain ATHK). Through independent experiments, scallops (Chlamys farreri) were fed for 9 days and mussels (Mytilus galloprovincialis) for 5 days plus an additional 5 days of depuration, with representative samples taken throughout...
May 16, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29775750/the-effects-of-capn1-gene-inactivation-on-the-differential-expression-of-genes-in-skeletal-muscle
#2
William T Olive, Brittney N Keel, Amanda K Lindholm-Perry, Justyna Horodyska, Andrew P Foote
Protein turnover is required for muscle growth and regeneration and several proteolytic enzymes, including the calpains, degrade myofibrillar proteins during this process. In a previous experiment, phenotypic differences were observed between μ-calpain knockout (KO) and wild type (WT) mice, including nutrient accretion and fiber type differences. These changes were particularly evident as the animals aged. Thus, we utilized 18 mice (9 KO and 9 WT) to compare transcript abundance to identify differentially expressed genes (DEGs) at 52 wk of age...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29774569/nonsynonymous-dna-variation-in-the-functional-domain-of-the-s100a7-a8-a9-genes-in-taurine-cattle-and-yak
#3
Zonggang Luo, Yuhui Wu, Wen-Xiu Zhang, Ling Wang, Fuyuan Zuo, Gong-Wei Zhang
No abstract text is available yet for this article.
May 18, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29770867/dietary-supplementation-with-an-amino-acid-blend-enhances-intestinal-function-in-piglets
#4
Dan Yi, Baocheng Li, Yongqing Hou, Lei Wang, Di Zhao, Hongbo Chen, Tao Wu, Ying Zhou, Binying Ding, Guoyao Wu
The traditionally classified nutritionally non-essential amino acids are now known to be insufficiently synthesized for maximal growth and optimal health in piglets. This study determined the effects of dietary supplementation with an amino acid blend (AAB; glutamate:glutamine:glycine:arginine:N-acetylcysteine = 5:2:2:1:0.5) on piglet growth performance and intestinal functions. Sixteen piglets (24-day-old) were randomly assigned to a corn and soybean meal-based diet supplemented with 0.99% alanine (isonitrogenous control) or 1% AAB...
May 16, 2018: Amino Acids
https://www.readbyqxmd.com/read/29770529/genome-wide-association-studies-identified-variants-for-taurine-concentration-in-japanese-black-beef
#5
Nanae Sasago, Masayuki Takeda, Tsuyoshi Ohtake, Tsuyoshi Abe, Hironori Sakuma, Takatoshi Kojima, Shinji Sasaki, Yoshinobu Uemoto
We performed genome-wide association studies (GWAS) using the BovineSNP50 array to detect significant single nucleotide polymorphisms (SNPs) that may affect the concentration of 22 free amino acids and three peptides in Japanese Black beef cattle. A total of 574 Japanese Black cattle and 40,657 SNPs from the array were used for this study. Genome-wide significant SNPs were detected for β-alanine (three SNPs on chromosomes 22 and 29) and taurine (26 SNPs on chromosome 22). Importantly, the top two SNPs for taurine were highly significant (p = 6...
May 16, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29765063/long-non-coding-rna-expression-patterns-in-lung-tissues-of-chronic-cigarette-smoke-induced-copd-mouse-model
#6
Haiyun Zhang, Dejun Sun, Defu Li, Zeguang Zheng, Jingyi Xu, Xue Liang, Chenting Zhang, Sheng Wang, Jian Wang, Wenju Lu
Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in various human diseases. In this study, we investigated transcriptome profiles in lung tissues of chronic cigarette smoke (CS)-induced COPD mouse model. We found that 109 lncRNAs and 260 mRNAs were significantly differential expressed in lungs of chronic CS-induced COPD mouse model compared with control animals. GO and KEGG analyses indicated that differentially expressed lncRNAs associated protein-coding genes were mainly involved in protein processing of endoplasmic reticulum pathway, and taurine and hypotaurine metabolism pathway...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29758259/structural-basis-for-polyamine-binding-at-the-dcache-domain-of-the-mcpu-chemoreceptor-from-pseudomonas-putida
#7
José Antonio Gavira, Álvaro Ortega, David Martín-Mora, María Teresa Conejero-Muriel, Andrés Corral-Lugo, Bertrand Morel, Miguel A Matilla, Tino Krell
Many bacteria can move chemotactically to a variety of compounds and the recognition of chemoeffectors by the chemoreceptor ligand binding domain (LBD) defines the specificity of response. Many chemoreceptors were found to recognize different amino- and organic acids, but the McpU chemoreceptor from Pseudomonas putida was identified as the first chemoreceptor that bound specifically polyamines. We report here the three-dimensional structure of McpU-LBD in complex with putrescine at a resolution of 2.4 Å, which fitted well a solution structure generated by Small Angle X-ray Scattering...
May 11, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29752090/one-step-preparation-of-polymeric-maltitol-particles-from-a-sugar-molecule-maltitol-for-biomedical-applications
#8
Nurettin Sahiner
Here, a facile method for the preparation of polymeric particles from a sugar molecule, maltitol (ML) in single step was reported via microemulsion polymerization/crosslinking technique with a high yield, 89 ± 6%. Furthermore, poly(Maltitol) (p(ML)) particles were chemically modified to induce different physicochemical characteristic using different anionic and cationic modifying agents such as taurine (TA) and diethylenetriamine (DETA) to prepare m-p(ML)/TA and m-p(ML)/DETA. The blood compatibility of the p(ML) particles and their modified forms were tested with fresh blood, and found that p(ML) and m-(ML)/DETA particles are blood compatible with about 5% hemolysis, and above 80% blood clotting indices...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29751815/changes-in-the-faecal-bile-acid-profile-in-dogs-fed-dry-food-vs-high-content-of-beef-a-pilot-study
#9
Kristin Marie Valand Herstad, Helene Thorsen Rønning, Anne Marie Bakke, Lars Moe, Ellen Skancke
BACKGROUND: Dogs are fed various diets, which also include components of animal origin. In humans, a high-fat/low-fibre diet is associated with higher faecal levels of bile acids, which can influence intestinal health. It is unknown how an animal-based diet high in fat and low in fibre influences the faecal bile acid levels and intestinal health in dogs. This study investigated the effects of high intake of minced beef on the faecal bile acid profile in healthy, adult, client-owned dogs (n = 8) in a 7-week trial...
May 11, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29750943/metabolomics-analysis-of-the-potential-anticancer-mechanism-of-annonaceous-acetogenins-on-a-multidrug-resistant-mammary-adenocarcinoma-cell
#10
Chengyao Ma, Yue Li, Hanqing Wu, Junyang Ji, Qianqian Sun, Yilin Song, Shen Wang, Xiang Li, Yong Chen, Jianwei Chen
Although annonaceous acetogenins (ACGs) have been reported to have antitumor activity for over three decades, and many of the underlying mechanism of ACGs on cancer have been clarified, there are still outstanding issues. In particular, the changes of small metabolite in cancer cells, caused by ACGs intake, have been reported rarely. Recent research has showed that cellular metabolic profiling coupled with ultra-flow liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UFLC-Q-TOF-MS) and multivariable statistical analysis enables a good understanding of ACGs' effects on multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells...
May 8, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29748917/taurine-protects-from-pentylenetetrazole-induced-behavioral-and-neurochemical-changes-in-zebrafish
#11
Barbara D Fontana, Paola R Ziani, Julia Canzian, Nathana J Mezzomo, Talise E Müller, Matheus M Dos Santos, Vania L Loro, Nilda V Barbosa, Carlos F Mello, Denis B Rosemberg
Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures, which culminate in various neurobehavioral and neurochemical changes. Taurine (TAU) is an amino sulfonic acid which acts an endogenous inhibitory neuromodulator. Moreover, TAU displays intrinsic antioxidant activity, contributing to its beneficial actions in the CNS. Here, we evaluated whether TAU pretreatment protects from pentylenetetrazole (PTZ)-induced behavioral alterations and oxidative stress-related parameters in zebrafish brain tissue...
May 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29747866/understanding-taurine-cns-activity-using-alternative-zebrafish-models
#12
Nathana J Mezzomo, Barbara D Fontana, Allan V Kalueff, Leonardo J G Barcellos, Denis B Rosemberg
Taurine is a highly abundant "amino acid" in the brain. Although the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action...
May 7, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29745050/aquaporin-4-knockout-mice-exhibit-increased-hypnotic-susceptibility-to-ketamine
#13
Yunluo Lv, Wangshu Dai, Ai Ge, Yi Fan, Gang Hu, Yinming Zeng
PURPOSE: This study examines anesthetic/hypnotic effects of ketamine in AQP4 knockout (KO) and wild-type (WT) mice with the particular focus on neurotransmission. MATERIALS AND METHODS: Ketamine (100 mg/kg) was intraperitoneally injected in 16 WT and 16 KO mice. The hypnotic potencies were evaluated by the loss of the righting reflex (LORR). The amino acids neurotransmitter levels in prefrontal cortex were measured by microdialysis. RESULTS: This study demonstrated that AQP4 knockout significantly shortened the latency compared with WT mice (98...
May 9, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29742691/long-non-coding-rna-taurine-upregulated-gene-1-predicts-unfavorable-prognosis-promotes-cells-proliferation-and-inhibits-cells-apoptosis-in-epithelial-ovarian-cancer
#14
Tong-Huai Li, Jing-Jing Zhang, Shao-Xiao Liu, Yan Chen
The aim of this study was to evaluate the correlation of long non-coding RNAs (lncRNAs) taurine-upregulated gene 1 (TUG1) with clinicopathological characteristics as well as overall survival (OS) in epithelial ovarian cancer (EOC) patients, and investigate its function in EOC cells proliferation and apoptosis in vitro.LncRNA TUG1 expressions were detected in tumor tissues and paired adjacent tissues obtained from 96 EOC patients. Blank mimic, lncRNA TUG1 mimic, blank inhibitor, and lncRNA TUG1 inhibitor plasmids were transfected into SKOV3 cells...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741708/direct-and-maternal-breed-additive-and-heterosis-effects-on-growth-traits-of-beef-cattle-raised-in-southern-brazil
#15
W S Leal, M D MacNeil, H G Carvalho, R Z Vaz, F F Cardoso
The objective of this study was to compare growth from birth to slaughter of different breed groups that were raised in Rio Grande do Sul, Brazil and estimate the consequent breed additive and heterosis effects. Caracu (C), Hereford (H), and Nelore (N) sires were mated with Angus (A) dams, and A sires were mated with H and N dams to produce a first generation of crossbred progeny that were contemporary with purebred A, H, and N calves. Heifers from this first generation (G1) were mated with Brangus (BN) and Braford (BO) sires to produce a second generation (G2) of progeny...
May 8, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29740359/profiling-of-amino-acids-and-their-derivatives-biogenic-amines-before-and-after-antipsychotic-treatment-in-first-episode-psychosis
#16
Liisa Leppik, Kärt Kriisa, Kati Koido, Kadri Koch, Kärolin Kajalaid, Liina Haring, Eero Vasar, Mihkel Zilmer
Schizophrenia (SCH) is a heterogeneous disorder, deriving from a potential multitude of etiopathogenetic factors. During the past few years there has been an increasing interest in the role of circulating amino acids (AAs) and biogenic amines (BAs) in the pathophysiology of SCH. In the present study, we aimed to provide an insight into the potential role of alterations in levels of AAs and BAs as well as examine their more specific metabolic shifts in relation to early stage of SCH. We measured 21 AAs and 17 BAs in serum samples of patients with first-episode psychosis (FEP) before and after 7-month antipsychotic treatment in comparison to control subjects (CSs)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29734439/optimization-of-human-semen-extender-components-for-cryopreservation-using-statistical-tools
#17
P M Ramesh, A S Vickram, T B Sridharan, R Parameswari, K Archana, S Nithya, A Mishika
  BACKGROUND: Human sperm cell preservation is an important part of assisted reproductive technology (ART). OBJECTIVE: This study aimed to find the essential and significant components in semen preservation extender required to prolong the shelf life of human spermatozoa. MATERIALS AND METHODS: By using the statistical tool 'Plackett-Burman design' the significant components present in E4 extender (formulated in our previous study) was determined by reducing the unacceptable large number of trial experiments from the full factorial method...
November 2017: Cryo Letters
https://www.readbyqxmd.com/read/29729635/an-integrative-investigation-of-the-therapeutic-mechanism-of-ainsliaea-fragrans-champ-in-cervicitis-using-liquid-chromatography-tandem-mass-spectrometry-based-on-a-rat-plasma-metabolomics-strategy
#18
Xiaoyong Zhang, Mingzhen He, Shuangxia Lei, Bei Wu, Ting Tan, Hui Ouyang, Wen Xu, Yulin Feng
Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Ainsliaea fragrans Champ. (AFC) has been widely used in clinical treatment of cervicitis. In the present study, we performed an integrative investigation involving histopathology analysis and non-target plasma metabolomics analysis in a cervicitis rat model induced by phenol mucilage, using ultra-performance liquid chromatography coupled with a tandem quadrupole time-of-flight mass spectrometry approach...
April 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29724268/validation-of-a-plasma-metabolomics-model-that-allows-anticipation-of-the-occurrence-of-cytomegalovirus-dnaaemia-in-allogeneic-stem-cell-transplant-recipients
#19
Daniel Monleón, Alberto Talaya, Estela Giménez, Víctor Vinuesa, José Manuel Morales, Juan Carlos Hernández-Boluda, Ariadna Pérez, José Luis Piñana, Carlos Solano, David Navarro
A plasma metabolomic model obtained by means of untargeted 1 H nuclear magnetic resonance, to which taurine, choline, methylamine, total glutathione, trimethylamine N-oxide, lactate, lysine, isoleucine, total fatty acids and unsaturated fatty acids contributed, was validated for the prediction of first episodes of cytomegalovirus (CMV) DNAaemia in a cohort of 79 allogeneic stem haematopoietic stem cell transplant (allo-HSCT) recipients. The predictive success rate was nearly 65 % for patients at both low and high risk of CMV-related complications according to their baseline characteristics...
May 4, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29721588/the-pharmacokinetics-and-metabolism-of-diclofenac-in-chimeric-humanized-and-murinized-frg-mice
#20
C E Wilson, A P Dickie, K Schreiter, R Wehr, E M Wilson, J Bial, N Scheer, I D Wilson, R J Riley
The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3...
May 2, 2018: Archives of Toxicology
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