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https://www.readbyqxmd.com/read/28803719/assessment-of-aortic-valve-calcium-load-by-multidetector-computed-tomography-anatomical-validation-impact-of-scanner-settings-and-incremental-diagnostic-value
#1
Jamila Boulif, Bernhard Gerber, Alisson Slimani, Siham Lazam, Christophe de Meester, Sophie Piérard, Agnès Pasquet, Anne-Catherine Pouleur, David Vancraeynest, Gébrine El Khoury, Laurent de Kerchove, Philippe Noirhomme, Jean-Louis Vanoverschelde
OBJECTIVES: To validate aortic valve calcium (AVC) load measurements by multidetector row computed tomography (MDCT), to evaluate the impact of tube potential and slice thickness on AVC scores, to examine the accuracy of AVC load in distinguishing severe from nonsevere aortic stenosis (AS) and to investigate its effectiveness as an alternative diagnosis method when echocardiography remains inconclusive. METHODS: We prospectively studied 266 consecutive patients with moderate to severe AS who underwent MDCT to measure AVC load and a comprehensive echocardiographic examination to assess AS severity...
July 29, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28797406/ct-detected-growth-of-coronary-artery%C3%A2-calcification-in-asymptomatic-middle-aged-subjects-and-association-with-15-biomarkers
#2
Søren Zöga Diederichsen, Mette Hjortdal Grønhøj, Hans Mickley, Oke Gerke, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Lars Melholt Rasmussen, Michael Hecht Olsen, Axel Diederichsen
OBJECTIVES: This study sought to determine the incidence and progression of coronary artery calcification (CAC) in asymptomatic middle-aged subjects and to evaluate the value of a broad panel of biomarkers in the prediction of CAC growth. BACKGROUND: CAC continues to be a major risk factor, but the value of biochemical markers in predicting CAC incidence and progression remains unresolved. METHODS: At baseline, 1,227 men and women underwent traditional risk assessment and a computed tomography (CT) scan to determine the CAC score...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28797402/the-identification-of-calcified-coronary-plaque-is-associated-with-initiation-and-continuation-of-pharmacological-and-lifestyle-preventive-therapies-a-systematic-review-and-meta-analysis
#3
Ankur Gupta, Emily Lau, Ravi Varshney, Edward A Hulten, Michael Cheezum, Marcio S Bittencourt, Michael J Blaha, Nathan D Wong, Roger S Blumenthal, Matthew J Budoff, Craig A Umscheid, Khurram Nasir, Ron Blankstein
OBJECTIVES: The aim of this study was to assess the odds of initiation or continuation of pharmacological and lifestyle preventive therapies in patients with nonzero versus zero coronary artery calcium (CAC) score detected on cardiac computed tomography. BACKGROUND: Detection of calcified coronary plaque could serve as a motivational tool for physicians and patients to intensify preventive therapies. METHODS: We searched PubMed, EMBASE (Excerpta Medica database), Web of Science, Cochrane CENTRAL (Cochrane central register of controlled trials), ClinicalTrials...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28792138/association-of-inter-arm-systolic-blood-pressure-difference-with-coronary-atherosclerotic-disease-burden-using-calcium-scoring
#4
Ae Young Her, Kyoung Im Cho, Scot Garg, Yong Hoon Kim, Eun Seok Shin
PURPOSE: There are no sufficient data on the correlation between inter-arm blood pressure (BP) difference and coronary atherosclerosis found using coronary artery calcium score (CACS). We aimed to investigate if the increased difference in inter-arm BP is independently associated with severity of CACS. MATERIALS AND METHODS: Patients who had ≥3 cardiovascular risk factors or an intermediate Framingham Risk Score (FRS; ≥10) were enrolled. Inter-arm BP difference was defined as the absolute difference in BP in both arms...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28791822/a-coronary-proatherosclerotic-marker-pregnancy-associated-plasma-protein-a-and-its-association-with-coronary-calcium-score-and-carotid-intima-media-thickness
#5
Abdullah Guven, Bora Demircelik, Ozgul Malcok Gurel, Okan Er, Halil Ibrahim Aydin, Alper Bozkurt
BACKGROUND: Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for the greatest number of deaths in westernized societies, with numbers increasing at a marked rate in developing countries. Coronary calcium score (CCS), carotid intima-media thickness (CIMT) and pregnancy-associated plasma protein A (PAPP-A) are predictors for the development of atherosclerosis. OBJECTIVES: This study was aimed to investigate the relationship between CCS, CIMT and PAPP-A for earlier diagnosis of atherosclerosis...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28771600/eicosapentaenoic-acid-prevents-arterial-calcification-in-klotho-mutant-mice
#6
Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Kei Yunoki, Yasushi Koyama, Minoru Satoh, Megumi Kondo, Kazuhiro Osawa, Omer F Hatipoglu, Toru Miyoshi, Masashi Yoshida, Hiroshi Morita, Hiroshi Ito
BACKGROUND: The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However, the effects of EPA on arterial calcification have not been fully elucidated. The aim of this study was to determine the effect of EPA on arterial calcification in klotho mutant mice...
2017: PloS One
https://www.readbyqxmd.com/read/28756086/iterative-beam-hardening-correction-with-advanced-modeled-iterative-reconstruction-in-low-voltage-ct-coronary-calcium-scoring-with-tin-filtration-impact-on-coronary-artery-calcium-quantification-and-image-quality
#7
Christian Tesche, Carlo N De Cecco, U Joseph Schoepf, Taylor M Duguay, Moritz H Albrecht, Damiano Caruso, Akos Varga-Szemes, Virginia W Lesslie, Ullrich Ebersberger, Christian Canstein, Christian Thilo, Ellen Hoffmann, Thomas Allmendinger, John W Nance
OBJECTIVE: We investigated the impact of iterative beam-hardening correction (IBHC) with advanced modeled iterative reconstruction (ADMIRE) of ultra-low radiation-dose tin filtered (Sn100 kVp) CACS acquisitions on image quality, calcium quantification, and risk classification. METHODS: CT data of 60 patients (55% male, age 62.3 ± 9.8years) who underwent a 3rd generation dual-source CACS scan using a prospectively ECG-triggered 100 kVp sequential acquisition protocol with tin filtration (Sn100 kVp) were reconstructed using IBHC with filtered back projection (FBP) and ADMIRE with strength levels of three and five...
July 24, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28754439/myocardial-blood-flow-reserve-is-impaired-in-patients-with-aortic-valve-calcification-and-unobstructed-epicardial-coronary-arteries
#8
Karen Nel, Michael C Y Nam, Chris Anstey, Christopher J Boos, Edward Carlton, Roxy Senior, Juan Carlos Kaski, Ahmed Khattab, Delva Shamley, Christopher D Byrne, Tony Stanton, Kim Greaves
BACKGROUND: Although calcific aortic valve disease (CAVD) is associated with coronary atherosclerosis, it is not known whether early CAVD is associated with coronary microcirculatory dysfunction (CMD). We sought to investigate the relationship between myocardial blood flow reserve (MBFR) - a measure of CMD, and early CAVD in the absence of obstructive epicardial coronary artery disease. We also determined whether this relationship was independent of coronary artery disease (CAD) and hs-CRP, a marker of systemic inflammation...
June 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28754436/sex-differences-in-coronary-atherosclerosis-progression-and-major-adverse-cardiac-events-in-patients-with-suspected-coronary-artery-disease
#9
Hui Gu, Yang Gao, Haiping Wang, Zhihui Hou, Lei Han, Ximing Wang, Bin Lu
BACKGROUND: Little is known about the influence of coronary atherosclerosis progression on the risk of major adverse cardiac events (MACE). Similarly, differences between men and women regarding atherosclerosis progression are poorly understood. The purpose of this study was to investigate the progression of coronary atherosclerosis by coronary CT angiography (coronary CTA) in men and women, and to evaluate its prognostic value regarding MACE. METHODS: This study included 1046 patients with suspected coronary artery disease (CAD) who underwent serial coronary CTA because of new or worsening symptoms or because follow-up coronary CTA had been recommended by attending physicians...
July 16, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28746709/association-of-coronary-artery-calcium-score-vs-age-with-cardiovascular-risk-in-older-adults-an-analysis-of-pooled-population-based-studies
#10
Yuichiro Yano, Christopher J O'Donnell, Lewis Kuller, Maryam Kavousi, Raimund Erbel, Hongyan Ning, Ralph D'Agostino, Anne B Newman, Khurram Nasir, Albert Hofman, Nils Lehmann, Klodian Dhana, Ron Blankstein, Udo Hoffmann, Stefan Möhlenkamp, Joseph M Massaro, Amir-Abbas Mahabadi, Joao A C Lima, M Arfan Ikram, Karl-Heinz Jöckel, Oscar H Franco, Kiang Liu, Donald Lloyd-Jones, Philip Greenland
Importance: Besides age, other discriminators of atherosclerotic cardiovascular disease (ASCVD) risk are needed in older adults. Objectives: To examine the predictive ability of coronary artery calcium (CAC) score vs age for incident ASCVD and how risk prediction changes by adding CAC score and removing only age from prediction models. Design, Setting, and Participants: We conducted an analysis of pooled US population-based studies, including the Framingham Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health Study...
July 26, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28741065/coronary-calcium-scoring-of-ct-attenuation-correction-scans-automatic-manual-or-visual
#11
EDITORIAL
Shifali Dumeer, Andrew J Einstein
No abstract text is available yet for this article.
July 24, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28740456/carotid-artery-stiffness-digital-endothelial-function-and-coronary-calcium-in-patients-with-essential-thrombocytosis-free-of-overt-atherosclerotic-disease
#12
Matjaz Vrtovec, Ajda Anzic, Irena Preloznik Zupan, Katja Zaletel, Ales Blinc
BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) are at increased risk for atherothrombotic events. Our aim was to determine if patients with essential thrombocytosis (ET), a subtype of MPNs, free of symptomatic atherosclerosis, have greater carotid artery stiffness, worse endothelial function, greater coronary calcium and carotid plaque burden than control subjects. PATIENTS AND METHODS: 40 ET patients without overt vascular disease, and 42 apparently healthy, age and sex-matched control subjects with comparable classical risk factors for atherosclerosis and Framingham risk of coronary disease were enrolled...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28729297/association-between-intracranial-atherosclerotic-calcium-burden-and-angiographic-luminal-stenosis-measurements
#13
H Baradaran, P Patel, G Gialdini, A Giambrone, M P Lerario, B B Navi, J K Min, C Iadecola, H Kamel, A Gupta
BACKGROUND AND PURPOSE: Calcification of the intracranial vasculature is an independent risk factor for stroke. The relationship between luminal stenosis and calcium burden in the intracranial circulation is incompletely understood. We evaluated the relationship between atherosclerotic calcification and luminal stenosis in the intracranial ICAs. MATERIALS AND METHODS: Using a prospective stroke registry, we identified patients who had both NCCT and CTA or MRA examinations as part of a diagnostic evaluation for ischemic stroke...
July 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28719492/fifty-men-3510-marathons-cardiac-risk-factors-and-coronary-artery-calcium-scores
#14
William O Roberts, Robert S Schwartz, Ross F Garberich, Samantha Carlson, Thomas Knickelbine, Jonathan G Schwartz, Gretchen Peichel, John R Lesser, Kelly Wickstrom, Kevin M Harris
INTRODUCTION/PURPOSE: Many male marathon runners have elevated coronary artery calcium (CAC) scores despite high physical activity. We examined the association between CAC scores, cardiovascular risk factors, and lifestyle habits in long term marathoners. METHODS: We recruited men who had run ≥1 marathon annually for 25 consecutive years. CAC was assessed using coronary computed tomography angiography. Atherosclerotic cardiovascular disease (CAD) risk factors were measured with a 12-lead ECG, serum lipid panel, height, weight, resting blood pressure and heart rate, and a risk factor questionnaire...
July 17, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28710871/detection-and-quantification-of-coronary-calcium-from-dual-energy-chest-x-rays-phantom-feasibility-study
#15
Bo Zhou, Di Wen, Katelyn Nye, Robert C Gilkeson, Brendan Eck, David Jordan, David L Wilson
PURPOSE: We have demonstrated the ability to identify coronary calcium, a reliable biomarker of coronary artery disease, using non-gated, 2-shot, dual energy (DE) chest x-ray imaging. Here we will use digital simulations, backed up by measurements, to characterize DE calcium signals and the role of potential confounds such as beam hardening, x-ray scatter, cardiac motion, and pulmonary artery pulsation. For the DE calcium signal, we will consider quantification, as compared to CT calcium score, and visualization...
July 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28686633/increased-risk-for-development-of-coronary-artery-calcification-in-subjects-with-non-alcoholic-fatty-liver-disease-and-systemic-inflammation
#16
Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
BACKGROUND: Recent studies have suggested the importance of non-alcoholic fatty liver disease (NAFLD) and systemic inflammation in the development of atherosclerosis. The aim of this study was to compare the risk for coronary artery calcification (CAC) development according to the status of NAFLD and inflammation over four years of follow-up in subjects without baseline CAC. METHODS: A total of 1,575 participants in a health screening program were divided into four groups according to baseline NAFLD state and high-sensitivity C-reactive protein (hs-CRP) (median 0...
2017: PloS One
https://www.readbyqxmd.com/read/28674321/incremental-prognostic-value-of-coronary-computed-tomography-angiography-high-risk-plaque-characteristics-in-asymptomatic-patients
#17
Kazuhisa Takamura, Shinichiro Fujimoto, Takeshi Kondo, Makoto Hiki, Yuko Kawaguchi, Etsuro Kato, Hiroyuki Daida
AIM: Coronary computed tomography angiography (CCTA) findings of positive remodeling (index >1.1) and low-attenuation plaque (<30 Hounsfield units) are recognized as CT-verified high-risk plaque (CT-HRP). Therefore, we investigated the incremental prognostic value of evaluation of plaque characteristics using CCTA in asymptomatic patients. METHODS: Overall, 495 consecutive patients without any known coronary artery disease who underwent CCTA were included in this study...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28670030/coronary-artery-calcium-score-current-status
#18
REVIEW
Priscilla Ornellas Neves, Joalbo Andrade, Henry Monção
The coronary artery calcium score plays an Important role In cardiovascular risk stratification, showing a significant association with the medium- or long-term occurrence of major cardiovascular events. Here, we discuss the following: protocols for the acquisition and quantification of the coronary artery calcium score by multidetector computed tomography; the role of the coronary artery calcium score in coronary risk stratification and its comparison with other clinical scores; its indications, interpretation, and prognosis in asymptomatic patients; and its use in patients who are symptomatic or have diabetes...
May 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28668419/dose-reduction-techniques-in-coronary-calcium-scoring-the-effect-of-iterative-reconstruction-combined-with-low-tube-voltage-on-calcium-scores-in-a-thoracic-phantom
#19
Marleen Vonder, Gert Jan Pelgrim, Mathias Meyer, Thomas Henzler, Matthijs Oudkerk, Rozemarijn Vliegenthart
OBJECTIVES: To define a dose-reduced coronary calcium CT protocol that provides similar calcium score values as a conventional 120kVp protocol. METHODS: A thorax phantom containing 100 calcifications was scanned with the reference protocol (120kVp, 90 ref mAs, FBP) and 30 dose-reduced protocols (70-110kVp, 90 ref mAs, FBP and iterative reconstruction (IR) levels 1-5) with 3rd generation dual-source CT. For protocols that yielded similar detectability and calcium scores as the reference protocol, additional scans were acquired at reduced ref mAs...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28663384/ct-angiography-images-of-coronary-artery-stenosis-provide-a-better-prediction-of-risk-than-traditional-risk-factors-in-asymptomatic-individuals-with-type-2-diabetes-a-long-term-study-of-clinical-outcomes
#20
Kwan Yong Lee, Byung-Hee Hwang, Tae-Hoon Kim, Chan Jun Kim, Jin-Jin Kim, Eun-Ho Choo, Ik Jun Choi, Young Choi, Ha-Wook Park, Yoon-Seok Koh, Pum-Joon Kim, Jong Min Lee, Mi-Jeong Kim, Doo Soo Jeon, Jae-Hyoung Cho, Jung Im Jung, Ki-Bae Seung, Kiyuk Chang
OBJECTIVE: We investigated the efficacy of coronary computed tomography angiography (CCTA) in predicting the long-term risks in asymptomatic patients with type 2 diabetes and compared it with traditional risk factors. RESEARCH DESIGN AND METHODS: We analyzed 933 patients with asymptomatic type 2 diabetes who underwent CCTA. Stenosis was considered obstructive (≥50%) in each coronary artery segment using CCTA. The extent and severity scores for coronary artery disease (CAD) were evaluated...
June 29, 2017: Diabetes Care
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