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Oliver Sartor
Radiopharmaceuticals used in the treatment of castrate-resistant prostate cancer are reviewed herein with an emphasis on sequential and combination therapies. Four bone-seeking radiopharmaceuticals had been approved in the United States. Three of these are β-emitters (phosphorus-32, strontium-89, samarium-153-ethylenediaminetetramethylene-phosphonic acid) that are approved for palliative purposes. One α-emitter (radium-223 [Ra]) is approved for prolongation of survival in bone metastatic castrate-resistant prostate cancer...
September 2016: Cancer Journal
Aaron F Cipriano, Amy Sallee, Myla Tayoba, Mayra C Cortez, Alan Lin, Ren-Guo Guan, Zhan-Yong Zhao, Huinan Liu
: Crystalline Mg-Zinc (Zn)-Strontium (Sr) ternary alloys consist of elements naturally present in the human body and provide attractive mechanical and biodegradable properties for a variety of biomedical applications. The first objective of this study was to investigate the degradation and cytocompatibility of four Mg-4Zn-xSr alloys (x = 0.15, 0.5, 1.0, 1.5 wt.%; designated as ZSr41A, B, C, and D respectively) in the direct culture with human umbilical vein endothelial cells (HUVEC) in vitro...
October 13, 2016: Acta Biomaterialia
R Jiménez-Ballesta, F J García-Navarro, S Bravo, J A Amorós, C Pérez-de-Los-Reyes, M Mejías
Contamination of aquatic systems with potentially toxic trace elements (PTEs) is a major problem throughout the world. The National Park Tablas de Daimiel (NPTD) is considered to make up one of the two most important wetlands in the Biosphere Reserve called "Wet Spot." Since PTEs are good indicator of the prevailing environmental conditions and possible contamination, soil samples collected from 43 sites were analyzed in order to investigate the levels and its distribution of these elements, in the inundated floodplain area of the NPTD wetland...
October 14, 2016: Environmental Geochemistry and Health
Hirofumi Kawanaka, Yoshihiro Aiura, Takayuki Hasebe, Makoto Yokoyama, Takahiko Masui, Yoshikazu Nishihara, Takashi Yanagisawa
The oxygen isotope effect of the ferromagnetic transition in itinerant ferromagnet strontium ruthenate SrRuO3 with a Curie temperature Tc of 160 K is studied. We observed for the first time a shift of ∆Tc ~ 1 K by oxygen isotope substitution of (16)O → (18)O in SrRuO3 by precise measurements of DC and AC magnetizations. The results surprisingly lead to the noteworthy inverse isotope effect with negative coefficient α = -∂ lnTc/∂ lnM. The Raman spectra indicate that the main vibration frequency of (16)O at 363 cm(-1) shifts to 341 cm(-1) following oxygen isotope substitution (18)O...
October 14, 2016: Scientific Reports
Agata Lazarowska, Sebastian Mahlik, Marek Grinberg, Guogang Li, Ru-Shi Liu
Spectroscopic properties of a series of (Sr0.98-xBaxEu0.02)Si2O2N2 (0 ≤ x ≤ 0.98) compounds has been studied under high hydrostatic pressure applied in a diamond anvil cell up to 200 kbar. At ambient pressure the crystal structures of (Sr0.98-xBaxEu0.02)Si2O2N2 (0 ≤ x ≤ 0.98) are related to the ratio of strontium to barium and three different phases exists: orthorhombic Pbcn(0.78 ≤ x ≤ 0.98), triclinic P1 (0 < x ≤ 0.65) and triclinic P1 (0.65 < x < 0...
October 13, 2016: Scientific Reports
Z H Fard, Y Kalinovskyy, D M Spasyuk, B A Blight, G K H Shimizu
A new rigid tritopic phosphonic ligand, 2,4,6-tris(4-phosphonophenyl)pyridine (H6L), was synthesized and used to assemble isostructural barium (1) and strontium (2) phosphonate metal organic frameworks that exhibit fully reversible and selective water-dependent fluorescence red-shift at room temperature.
October 13, 2016: Chemical Communications: Chem Comm
Diego H Díaz, Julieta A Rodas, Clarisa E Bozzini, Patricia M Mandalunis, Natalia D Escudero
Bisphosphonates are the first choice therapy for the pharmaco logical treatment of osteoporosis. Following reports of cases of bisphosphonaterelated osteonecrosis of the jaw and atypical femur fracture, the safety of longterm use of bisphosphonates has been evaluated, resulting in the proposal of strontium as an alternative drug. No experimental study using a sequential administration design has been reported to date. Hence, the aim of this study was to evaluate the effect on bone tissue of ovariectomized rats of administration of alendronate followed by strontium ranelate...
September 2016: Acta Odontológica Latinoamericana: AOL
Piyaphong Panpisut, Saad Liaqat, Eleni Zacharaki, Wendy Xia, Haralampos Petridis, Anne Margaret Young
PURPOSE: This study developed light cured dental composites with added monocalcium phosphate monohydrate (MCPM), tristrontium phosphate (TSrP) and antimicrobial polylysine (PLS). The aim was to produce composites that have enhanced water sorption induced expansion, can promote apatite precipitation and release polylysine. MATERIALS AND METHODS: Experimental composite formulations consisted of light activated dimethacrylate monomers combined with 80 wt% powder. The powder phase contained a dental glass with and without PLS (2...
2016: PloS One
Regina M B O Duarte, João T V Matos, Andreia S Paula, Sónia P Lopes, Sara Ribeiro, José Francisco Santos, Carla Patinha, Eduardo Ferreira da Silva, Rosário Soares, Armando C Duarte
In the framework of two national research projects (ORGANOSOL and CN-linkAIR), fine particulate matter (PM2.5) was sampled for 17 months at an urban location in the Western European Coast. The PM2.5 samples were analyzed for organic carbon (OC), water-soluble organic carbon (WSOC), elemental carbon (EC), major water-soluble inorganic ions, mineralogical, and for the first time in this region, strontium isotope ((87)Sr/(86)Sr) composition. Organic matter dominates the identifiable urban PM2.5 mass, followed by secondary inorganic aerosols...
October 10, 2016: Environmental Science and Pollution Research International
Leonardo Triggiani, Ana B Muñoz-García, Angela Agostiano, Michele Pavone
Strontium titanate (SrTiO3, STO) is a prototypical perovskite oxide, widely exploited in many technological applications, from catalysis to energy conversion devices. In the context of solid-oxide fuel cells, STO has been recently applied as an epitaxial substrate for nano-sized layers of mixed ion-electron conductive catalysts with enhanced electrochemical performances. To extend the applications of such heterogeneous nano-cathodes in real devices, also the STO support should be active for both electron transport and oxide diffusion...
October 11, 2016: Physical Chemistry Chemical Physics: PCCP
Lawrence A Crosby, Robert M Kennedy, Bor-Rong Chen, Jianguo Wen, Kenneth R Poeppelmeier, Michael J Bedzyk, Laurence D Marks
The surface structure of (110) faceted strontium titanate nanoparticles synthesized via solvothermal method has been resolved using high-resolution electron microscopy (HREM). We demonstrate that the surface is a titania-rich structure containing tetrahedrally coordinated TiO4 units similar to the family of (n × 1) reconstructions observed on (110) surfaces of bulk crystalline strontium titanate. When compared with prior results for (001) terminated strontium titanate single crystals made with traditional transmission electron microscopy (TEM) sample preparation techniques, the results demonstrate that many models for oxide nanoparticles need to be revisited...
September 22, 2016: Nanoscale
Marcela Martin-Del-Campo, Raul Rosales-Ibañez, Keila Alvarado, Jose G Sampedro, Christian A Garcia-Sepulveda, Sanjukta Deb, Julio San Román, Luis Rojo
Strontium folate (SrFO) is a recently developed bone promoting agent with interest in medical and pharmaceutical fields due to its improved features in comparison to current strontium based therapies for osteoporosis and other bone diseases. In this work SrFO derivative was synthesized and loaded into biohybrid scaffolds obtained through lyophilisation of semi-interpenetrating networks of chitosan polyethylene glycol dimethacrylate and beta tri-calcium phosphate (βTCP) fabricated using free radical polymerization...
October 18, 2016: Biomaterials Science
Clara Ferreira, Daniel Johnson, Karl Rasmussen, Clinton Leinweber, Salahuddin Ahmad, Jae Won Jung
PURPOSE: To develop a novel conformal superficial brachytherapy (CSBT) device as a treatment option for the patient-specific radiation therapy of conditions including superficial lesions, postsurgical positive margins, Dupuytren's contractures, keloid scars, and complex anatomic sites (eyelids, nose, ears, etc.). METHODS AND MATERIALS: A preliminary CSBT device prototype was designed, built, and tested using readily available radioactive seeds. Iodine-125 ((125)I) seeds were independently guided to the treatment surface to conform to the target...
October 3, 2016: Brachytherapy
Anna Carita Callan, Andrea Lee Hinwood, Jane Heyworth, Duong Trong Phi, Jon Ø Odland
Prenatal exposure to persistent pollutants has been associated with adverse birth outcomes, although few studies have investigated the influence of the sex of the infant. Sex specific differences have been associated with neurobehavioural impacts from environmental exposures with limited and contrary findings in relation to persistent pollutants. This study investigated the relationships between maternal exposure to a range of metals, polychlorinated biphenyls and pesticides measured in biological samples and birth outcomes with a specific focus on the sex of the infant...
September 28, 2016: International Journal of Hygiene and Environmental Health
Daniel Pérez-Del-Rey, Dávid Forgács, Eline M Hutter, Tom J Savenije, Dennis Nordlund, Philip Schulz, Joseph J Berry, Michele Sessolo, Henk J Bolink
The addition of Sr(2+) in CH3 NH3 PbI3 perovskite films enhances the charge carrier collection efficiency of solar cells leading to very high fill factors, up to 85%. The charge carrier lifetime of Sr(2+) -containing perovskites is in excess of 40 μs, longer than those reported for perovskite single crystals.
September 22, 2016: Advanced Materials
Sydney Peng, Zhi-Teng Lai, Ding-Wei Hong, I-Ming Chu, Po-Liang Lai
BACKGROUND: The aim of this study was to develop a minimally invasive hydrogel system that can release strontium ions, an element that has been shown to increase osteoblast proliferation and prohibit bone resorption, in a controlled manner. METHODS: SrCO3 was selected as the salt of choice due to potential acid neutralization reaction between SrCO3 and degradation by-products of methoxy(polyethylene glycol)-co-poly(lactic-co-glycolic acid) (mPEG-PLGA): namely, lactic acid and glycolic acid...
September 27, 2016: Journal of Applied Biomaterials & Functional Materials
Spiros Manolakos, Francy Sinatra, Leila Nikkhouy Albers, Kevin Hufford, James Alberti, Erkinjon G Nazarov, Theresa Evans-Nguyen
Differential mobility spectrometry (DMS) is applied to the analysis of inorganic mixtures relevant to nuclear forensics. Three primary components of potential radiological dispersal devices (RDDs): cobalt, cesium, and strontium, were studied by DMS to demonstrate rapid sample clean-up when coupled to mass spectrometry. Nanosprayed salt solutions comprised of stable analogs, as proxies to these radioisotopes, and isobaric interferents were introduced to DMS. The DMS effluent was directly coupled to a mass spectrometer to confirm the elemental identity of the separated clusters...
October 7, 2016: Analytical Chemistry
Nithavong Cam, Karim Benzerara, Thomas Georgelin, Maguy Jaber, Jean-Francois Lambert, Melanie Poinsot, Feriel Skouri-Panet, Laure Cordier
The uptakes of Ca, Sr and Ba by two cyanobacterial strains, Cyanothece sp. PCC7425 and Gloeomargarita lithophora, both forming intracellular carbonates, were investigated in laboratory cultures. In the culture medium BG 11 amended with 250 μM of Ca and 50 or 250 μM of Sr and Ba, G. lithophora accumulated first Ba, then Sr and finally Ca. Strontium and barium were completely accumulated by G. lithophora cells at rates between 0.02 and 0.10 fmol.h-1.cell-1 and down to extracellular concentrations below the detection limits of ICP-AES...
October 6, 2016: Environmental Science & Technology
Matthias Grünbacher, Eva-Maria Köck, Michaela Kogler, Bernhard Klötzer, Simon Penner
Two mixed ionic-electronic conducting, Fe-containing perovskites were investigated regarding their reducibility in dry H2, namely lanthanum strontium ferrite (LSF4, La0.6Sr0.4FeO3-δ) and strontium titanium ferrite (STF3, SrTi0.7Fe0.3O3-δ). Upon treatment under comparable reduction conditions, LSF4 is by far more affected by reduction and is reduced more deeply than STF3. Thermal treatments of fully oxidized or slightly reduced LSF4/STF3 at decreased O2 partial pressure lead to spontaneous desorption of O2...
September 29, 2016: Physical Chemistry Chemical Physics: PCCP
Akihiko Nakatsuka, Kazumasa Sugiyama, Makio Ohkawa, Osamu Ohtaka, Keiko Fujiwara, Akira Yoshiasa
The Sr-Ge-O system has an earth-scientific importance as a potentially good low-pressure analog of the Ca-Si-O system, one of the major components in the constituent minerals of the Earth's crust and mantle. However, it is one of the germanate systems that has not yet been fully examined in the phase relations and structural properties. The recent findings that the SrGeO3 high-pressure perovskite phase is the first Ge-based transparent electronic conductor make the Sr-Ge-O system interesting in the field of materials science...
October 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
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