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https://www.readbyqxmd.com/read/29680322/dose-response-in-choroidal-melanoma
#1
Alex De Caluwé, Karolien Termote, Dirk Van Gestel, Erik Van Limbergen
PURPOSE: In choroidal melanoma the radiation threshold dose for local control remains largely unknown. The present study examined a group of patients that received a wide range of minimum tumor dose in order to investigate a dose-response relationship. A literature review is performed to compare our results with available evidence in brachytherapy and charged particle external beam radiotherapy. MATERIALS AND METHODS: A retrospective study was conducted on all choroidal melanomas treated with Strontium-90 (Sr-90) at the University Hospital of Leuven between 1983 and 2012...
April 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29679808/%C3%AE-tricalcium-phosphate-composite-ceramics-with-high-compressive-strength-enhanced-osteogenesis-and-inhibited-osteoclastic-activities
#2
Ye Tian, Teliang Lu, Fupo He, Yubin Xu, Haishan Shi, Xuetao Shi, Fei Zuo, Shanghua Wu, Jiandong Ye
β-tricalcium phosphate (β-TCP) is well known as a resorbable bone repair material due to its inherent excellent biocompatibility and osteoconductivity. However, β-TCP is encountered with osteostimulation-deficiency and poor mechanical strength because of poor sinterability. Herein, we prepared novel β-TCP composite ceramics (TCP/SPGs) by introducing strontium-containing phosphate-based glass (SPG; 45P2 O5 -32SrO-23Na2 O) as sintering additive. The SPG helped to achieve efficient liquid-phase sintering of β-TCP at 1100 °C...
April 13, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29676197/pharmacokinetics-and-bioequivalence-of-two-strontium-ranelate-formulations-after-single-oral-administration-in-healthy-chinese-subjects
#3
Dan Zhang, Jingyi Ma, Aihua Du, Xiaolin Wang, Lina Zhang, Man Yang, Ming Deng, Huichen Liu
1. Pharmacokinetics of exogenous Sr and bioequivalence of a new oral formulation of strontium ranelate compared with the brand-name drug in healthy Chinese subjects was evaluated. 2. A balanced, randomized, single-dose, 2-treatment parallel study was conducted in 36 healthy Chinese subjects. Subjects were randomly allocated into two groups of 18 to receive a single oral dose of test formulation and reference formulation under a fasting state, respectively. Blood samples were collected at 19 designated time points up to 240 h post-dose...
April 20, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29676117/-geographical-origin-discriminant-of-dendrobium-officinale-based-on-stable-isotope-ratios
#4
Jian Yang, Hao Wu, Chao-Geng Lv, Sheng Wang, Xiao-Bo Zhang, Guang Yang, Lan-Ping Guo, Lu-Qi Huang
The isotopic ratios of strontium isotope (Sr) and light elements (C/H/O/N) in Dendrobium officinale from different producing areas (Shaoguan, Guangdong; Yulin, Guangxi; Shibing, Guizhou; Wenshan, Yunnan and Zhejiang province) were determined with thermal ionization mass spectrometry (TI-MS) and isotope ratio mass spectrometry (IRMS).The differences of the stable isotope ratios in D. officinale were obtained by the variance analysis and the correlation analysis, and pattern recognition techniques with principal component analysis (PCA) was used to classify the geographical origins of D...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29670155/soft-x-ray-heterogeneous-radiolysis-of-pyridine-in-the-presence-of-hydrated-strontium-hydroxyhectorite-and-its-monitoring-by-near-ambient-pressure-photoelectron-spectroscopy
#5
Anthony Boucly, François Rochet, Quentin Arnoux, Jean-Jacques Gallet, Fabrice Bournel, Héloïse Tissot, Virginie Marry, Emmanuelle Dubois, Laurent Michot
The heterogeneous radiolysis of organic molecules in clays is a matter of considerable interest in astrochemistry and environmental sciences. However, little is known about the effects of highly ionizing soft X-rays. By combining monochromatized synchrotron source irradiation with in situ Near Ambient Pressure X-ray Photoelectron Spectroscopy (in the mbar range), and using the synoptic view encompassing both the gas and condensed phases, we found the water and pyridine pressure conditions under which pyridine is decomposed in the presence of synthetic Sr2+ -hydroxyhectorite...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667172/mapping-the-origins-of-imperial-roman-workers-1st-4th-century-ce-at-vagnari-southern-italy-using-87-sr-86-sr-and-%C3%AE-18-o-variability
#6
Matthew V Emery, Robert J Stark, Tyler J Murchie, Spencer Elford, Henry P Schwarcz, Tracy L Prowse
OBJECTIVES: We obtained the oxygen and strontium isotope composition of teeth from Roman period (1st to 4th century CE) inhabitants buried in the Vagnari cemetery (Southern Italy), and present the first strontium isotope variation map of the Italian peninsula using previously published data sets and new strontium data. We test the hypothesis that the Vagnari population was predominantly composed of local individuals, instead of migrants originating from abroad. MATERIALS AND METHODS: We analyzed the oxygen (18 O/16 O) and strontium (87 Sr/86 Sr) isotope composition of 43 teeth...
April 18, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29665441/nanorod-diameter-modulated-osteogenic-activity-of-hierarchical-micropore-nanorod-patterned-coatings-via-a-wnt-%C3%AE-catenin-pathway
#7
Jianhong Zhou, Lingzhou Zhao, Bo Li, Yong Han
Hierarchical micropore/nanorod-patterned strontium doped hydroxyapatite (Ca9 Sr1 (PO4 )6 (OH)2 , Sr1 -HA) structures (MNRs) with different nanorod diameters of about 30, 70 and 150 nm were coated on titanium, to investigate the effect of nanorod diameter on osteogenesis and the involved mechanism. Compared to micropore/nanogranule-patterned Sr1 -HA coating (MNG), MNRs gave rise to dramatically enhanced in vitro mesenchymal stem cell functions including osteogenic differentiation in the absence of osteogenic supplements and in vivo osseointegration related to the nanorod diameter with about 70 nm displaying the best effects...
April 14, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29655723/thermal-behavior-of-inosine-5-monophosphate-in-acidic-form-and-as-alkali-and-alkaline-earth-salts
#8
J H F de Jesus, A P G Ferreira, E T G Cavalheiro
Inosine 5'-monophosphate in acidic form and its lithium, potassium, magnesium, calcium, strontium and barium were prepared from the sodium salt, characterized by elemental analysis and Fourier transform infrared spectroscopy and submitted to thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC) and thermogravimetry coupled to infrared spectroscopy (TG-FTIR) of the volatile products evolved during heating. All the salts were hydrated containing from 4 to 7.5 H2 O...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29651726/biosorption-of-strontium-ions-from-simulated-high-level-liquid-waste-by-living-saccharomyces-cerevisiae
#9
Liang Qiu, Jundong Feng, Yaodong Dai, Shuquan Chang
In this study, the Saccharomyces cerevisiae (S. cerevisiae) was modified by γ-ray. The RNA-seq results reflect that the high γ-ray energies could change some gene fragments, such as deletion, recombination, and mutation. The biosorption of strontium ions (Sr2+ ) to different types of S. cerevisiae (S. cerevisiae (K-0), modified S. cerevisiae (Y-7), and non-living S. cerevisiae (H-K)) from the simulated high-level liquid waste (S-HLLW) was assessed at different experimental conditions. The sorption experimental results show that, under an appropriate condition, γ-ray radiation can enhance its biosorption capacity slightly of Sr2+ to S...
April 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29627679/bone-tissue-engineering-strategy-based-on-the-synergistic-effects-of-silicon-and-strontium-ions
#10
Min Xing, Xiaoya Wang, Endian Wang, Long Gao, Jiang Chang
Multipotent human bone marrow mesenchymal stem cells (hBMSCs) are commonly used as seed cells in bone tissue engineering, but their clinical application is limited due to two challenges. One is the expansion of hBMSCs without loss of the stemness, and the other is the stimulation of osteogenic differentiation of hBMSCs when combined with biomaterials. In this study we demonstrated an approach by firstly elucidating the functional effects and optimal concentrations of Si and Sr ions on the proliferation and osteogenic differentiation of hBMSCs, and then designing bioactive bioceramic/alginate hydrogels which could release Si and Sr bioactive ions in the same optimal concentrations range for activation of the cells in vivo...
April 5, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29626698/in-vitro-evaluation-of-mgsr-and-mgcasr-alloys-via-direct-culture-with-bone-marrow-derived-mesenchymal-stem-cells
#11
Wensen Jiang, Aaron F Cipriano, Qiaomu Tian, Chaoxing Zhang, Marisa Lopez, Amy Sallee, Alan Lin, Mayra Celene Cortez Alcaraz, Yuanhao Wu, Yufeng Zheng, Huinan Liu
Magnesium (Mg) and its alloys have been widely investigated as the most promising biodegradable metals to replace conventional non-degradable metals for temporary medical implant applications. New Mg alloys have been developed for medical applications in recent years; and the concept of alloying Mg with less-toxic elements have aroused tremendous interests due to the promise to address the problems associated with rapid degradation of Mg without compromising its cytocompatibility and biocompatibility. Of particular interests for orthopedic/spinal implant applications are the additions of calcium (Ca) and strontium (Sr) into Mg matrix because of their beneficial properties for bone regeneration...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29623650/multi-scale-approach-for-the-evaluation-of-bone-mineralization-in-strontium-ranelate-treated-diabetic-rats
#12
Pedro Álvarez-Lloret, Juan Manuel Fernández, María Silvina Molinuevo, Agustina Berenice Lino, José Luis Ferretti, Ricardo Francisco Capozza, Ana María Cortizo, Antonio Desmond McCarthy
Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteoporotic agent whose use in individuals with diabetic osteopathy has not been adequately evaluated. In this study, we studied the effects of an oral treatment with SrR and/or experimental diabetes on bone composition and biomechanics. Young male Wistar rats (half non-diabetic, half with streptozotocin/nicotinamide-induced diabetes) were either untreated or orally administered 625 mg/kg/day of SrR for 6 weeks...
April 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29619640/efficient-removal-of-arsenic-iii-from-aqueous-media-using-magnetic-polyaniline-doped-strontium-titanium-nanocomposite
#13
Mohammad Kazem Mohammadi Nodeh, Mohammad Ali Gabris, Hamid Rashidi Nodeh, Mehdi Esmaeili Bidhendi
In this study, a novel nanocomposite adsorbent based on magnetic polyaniline and strontium-titanium (MP-SrTiO3 ) nanoparticles was synthesized via a simple and low-cost polymerization method for efficiently removing of arsenic(III) ions from aqueous samples. The chemical structure, surface properties, and morphology of the prepared adsorbent were studied using Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDX), and scanning electron microscopy (SEM). The main effective parameters on the removal efficiency, such as pH, adsorbent dosage, salt, and contact time, were studied and optimized...
April 4, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29618838/opportunistic-migration-and-habitat-use-of-the-giant-mottled-eel-anguilla-marmorata-teleostei-elopomorpha
#14
Takaomi Arai, Naoko Chino
Freshwater eels have fascinated biologists for centuries due to the spectacular long-distance migrations between their freshwater habitats and their spawning areas far out in the ocean. Although freshwater eels originated in the Indonesian region, remarkably little is known about the life history of tropical freshwater eels. The diverse migratory patterns and habitat choice between marine and freshwater environments by the giant mottled eel Anguilla marmorata Quoy & Gaimard, 1824 were examined by analysing the otolith strontium (Sr) and calcium (Ca) concentrations collected in Asian waters...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614122/complexes-of-myo-inositol-hexakisphosphate-insp6-with-zinc-or-lanthanum-to-enhance-excretion-of-radioactive-strontium-from-the-body
#15
Kazuma Ogawa, Miho Aoki, Sumi Kadono, Akira Odani
90Sr, which was released into the atmosphere and the ocean following the Chernobyl and Fukushima Daiichi nuclear power plant disasters, is an important nuclear fission element. Compounds that inhibit the absorption of 90Sr into the bloodstream and enhance its elimination can be beneficial in decreasing the absorbed radiation dose in people exposed to 90Sr. Recently, we prepared complexes of myo-inositol-hexakisphosphate (InsP6) with zinc or lanthanum as decorporation agents. These complexes, called Zn-InsP6 and La-InsP6 respectively, are insoluble in water and can potentially chelate additional metal cations...
2018: PloS One
https://www.readbyqxmd.com/read/29599615/biomimetic-mineralized-strontium-doped-hydroxyapatite-on-porous-poly-l-lactic-acid-scaffolds-for-bone-defect-repair
#16
Min Ge, Kun Ge, Fei Gao, Weixiao Yan, Huifang Liu, Li Xue, Yi Jin, Haiyun Ma, Jinchao Zhang
Introduction: poly(l-lactic acid) (PLLA) has been approved for clinical use by the US Food and Drug Administration (FDA); however, their stronger hydrophobicity and relatively fast degradation rate restricted their widespread application. In consideration of the composition of bone, the inorganic-organic composite has a great application prospect in bone tissue engineering. Many inorganic-organic composite scaffolds were prepared by directly mixing the active ingredient, but this method is uncontrolled and will lead to lack of homogeneity in the polymer matrix...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29590155/unravelling-biocultural-population-structure-in-4th-3rd-century-bc-monterenzio-vecchio-bologna-italy-through-a-comparative-analysis-of-strontium-isotopes-non-metric-dental-evidence-and-funerary-practices
#17
Rita Sorrentino, Eugenio Bortolini, Federico Lugli, Giuseppe Mancuso, Laura Buti, Gregorio Oxilia, Antonino Vazzana, Carla Figus, Maria Cristina Serrangeli, Cristiana Margherita, Annachiara Penzo, Giorgio Gruppioni, Antonio Gottarelli, Klaus Peter Jochum, Maria Giovanna Belcastro, Anna Cipriani, Robin N M Feeney, Stefano Benazzi
The 4th century BC marks the main entrance of Celtic populations in northern Italy. Their arrival has been suggested based on the presence of Celtic customs in Etruscan mortuary contexts, yet up to now few bioarchaeological data have been examined to support or reject the arrival of these newcomers. Here we use strontium isotopes, non-metric dental traits and funerary patterns to unravel the biocultural structure of the necropolis of Monterenzio Vecchio (Bologna, Italy). Subsamples of our total sample of 38 individuals were analyzed based on different criteria characterizing the following analyses: 1) strontium isotope analysis to investigate migratory patterns and provenance; 2) non-metric dental traits to establish biological relationships between Monterenzio Vecchio, 13 Italian Iron age necropolises and three continental and non-continental Celtic necropolises; 3) grave goods which were statistically explored to detect possible patterns of cultural variability...
2018: PloS One
https://www.readbyqxmd.com/read/29589608/insight-into-selectivity-uptake-studies-of-radionuclides-90-sr-2-137-cs-and-233-uo-2-2-with-bis-amidoxime-polymers
#18
Marek Piechowicz, R Chiarizia, L Soderholm
Uptake characteristics of a bis-amidoximated polymer are presented for 90Sr2+, 137Cs+, and 233UO22+ to assess rational ligand design and polymer engineering efforts applied to selective uranium extraction. Functionalized with the bis-amidoxime diaryl ether ligand at a loading of 1.98 mmol per gram of polymer, the polymer was found to sorb uranium from a pH 6 solution with a separation factor (α) over cesium of 1.2 × 103. Strontium uptake was negligible throughout the pH range studied whereas cesium uptake averaged <30%...
March 28, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29578147/comparison-of-the-efficacy-of-strontium-89-chloride-in-treating-bone-metastasis-of-lung-breast-and-prostate-cancers
#19
Xiaojuan Ye, Da Sun, Cen Lou
Objective: The aim of this study was to comparatively evaluate the efficacy of strontium-89 chloride (89 SrCl2 ) in treating bone metastasis-associated pain in patients with lung, breast, or prostate cancer. Materials and Methods: The 126 patients with lung cancer included 88, 16, 15, 4, and 3 patients with adenocarcinoma, squamous cell carcinoma, nonsmall cell carcinoma, mixed carcinoma, and small cell carcinoma, respectively, and the control group consisted of patients with breast (71 patients) or prostate cancer (49 patients) who underwent89 SrCl2 treatment during the same period...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29576572/effect-of-demineralization-time-on-the-mineral-composition-and-mechanical-properties-of-remineralized-dentin
#20
Olivier Lavigne, Anh M Vu, Lindsay Richards, Zonghan Xie
The aim of this study was to determine whether recovery of mineral levels restored the mechanical properties of dentin subjected to different durations of demineralization. Dentin at the floor of class 1 cavities (n = 12) was demineralized for 1, 2, and 3 weeks. Half the demineralized cavity floor was coated (control side), and a Fuji IX restoration was placed. The remaining half was therefore in contact with the Fuji IX restoration (test side). Simulated dentin tubular fluid was then supplied to each pulp chamber for 6 weeks...
2018: Journal of Oral Science
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