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https://www.readbyqxmd.com/read/28102439/reconstruction-of-radionuclide-intakes-for-the-residents-of-east-urals-radioactive-trace-1957-2011
#1
Evgenia I Tolstykh, Lyudmila M Peremyslova, Marina O Degteva, Bruce A Napier
The East Urals Radioactive Trace (EURT) was formed after a chemical explosion in the radioactive waste-storage facility of the Mayak Production Association in 1957 (Southern Urals, Russia) and resulted in an activity dispersion of 7.4 × 10(16) Bq into the atmosphere. Internal exposure due to ingestion of radionuclides with local foodstuffs was the main factor of public exposure at the EURT. The EURT cohort, combining residents of most contaminated settlements, was formed for epidemiological study at the Urals Research Center for Radiation Medicine, Russia (URCRM)...
January 19, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28094246/development-of-sr-incorporated-biphasic-calcium-phosphate-bone-cement
#2
Hui Zhu, Dagang Guo, Wenli Qi, Kewei Xu
To follow the design strategy of traditional biphasic calcium phosphate (BCP) ceramic, in the present study, strontium-doped biphasic calcium phosphate bone cement (Sr-BCPC) composites comprising Sr-β-tricalcium phosphate (TCP)/Sr-hydroxyapatite (HAP) had been prepared for the first time using Sr x -β-TCP/tetracalcium phosphate (TTCP) as a cement powder and diluted phosphoric acid as a cement liquid. The phase composition, setting time, compressive strength, washout resistance, in vitro degradation rate, microstructure evolutions, hydration dynamics and cytotoxicity of Sr-BCPC at various Sr contents were intensively investigated...
January 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28092725/strontium-ranelate-a-promising-disease-modifying-osteoarthritis-drug
#3
Weiyu Han, Shicai Fan, Xiaochun Bai, Changhai Ding
The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balance between bone resorption and bone formation. Its effect on subchondral bone makes it a potential disease- modifying osteoarthritis drug (DMOAD) in the treatment of OA. The aim of the current review is to summarize up-to-date pharmacological and clinical data of SrR for OA treatment...
January 16, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28074835/topological-dirac-nodal-lines-and-surface-charges-in-fcc-alkaline-earth-metals
#4
Motoaki Hirayama, Ryo Okugawa, Takashi Miyake, Shuichi Murakami
In nodal-line semimetals, the gaps close along loops in k space, which are not at high-symmetry points. Typical mechanisms for the emergence of nodal lines involve mirror symmetry and the π Berry phase. Here we show via ab initio calculations that fcc calcium (Ca), strontium (Sr) and ytterbium (Yb) have topological nodal lines with the π Berry phase near the Fermi level, when spin-orbit interaction is neglected. In particular, Ca becomes a nodal-line semimetal at high pressure. Owing to nodal lines, the Zak phase becomes either π or 0, depending on the wavevector k, and the π Zak phase leads to surface polarization charge...
January 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28072516/cobalt-based-single-ion-magnets-on-an-apatite-lattice-toward-patterned-arrays-for-magnetic-memories
#5
Pavel E Kazin, Mikhail A Zykin, Walter Schnelle, Yan V Zubavichus, Konstantin A Babeshkin, Victor A Tafeenko, Claudia Felser, Martin Jansen
Single-ion magnets (SIMs) that can maintain magnetization direction on an individual transition metal atom represent the smallest atomic-scale units for future magnetic data storage devices and molecular electronics. Here we present a robust extended inorganic solid hosting efficient SIM centers, as an alternative to molecular SIM crystals. We show that unique dioxocobaltate(II) ions, confined in the channels of strontium hydroxyapatite, exhibit classical SIM features with a large energy barrier for magnetization reversal (Ueff) of 51-59 cm(-1)...
January 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28068758/strontium-doped-amorphous-calcium-phosphate-porous-microspheres-synthesized-through-a-microwave-hydrothermal-method-using-fructose-1-6-bisphosphate-as-an-organic-phosphorus-source-application-in-drug-delivery-and-enhanced-bone-regeneration
#6
Weilin Yu, Tuan-Wei Sun, Chao Qi, Zhen-Yu Ding, Hua-Kun Zhao, Feng Chen, Dao-Yun Chen, Ying-Jie Zhu, Zhongmin Shi, Yaohua He
Nanostructured calcium phosphate (CaP) porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt (FBP) as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28067360/photoelectrochemical-water-splitting-with-a-srtio3-nb-srtio3-n-n-homojunction-structure
#7
Jiajie Cen, Qiyuan Wu, Danhua Yan, Jing Tao, Kim Kisslinger, Mingzhao Liu, Alexander Orlov
A very limited knowledge exists about the effect of non-uniform doping of epitaxially grown strontium titanate thin film electrodes on their photoelectrochemical performance in water splitting. In this work, water splitting photoanodes featuring an n(+)-n homojunction were fabricated by the pulsed laser deposition technique, where epitaxial SrTiO3 thin films were grown on Nb doped n(+)-SrTiO3 single crystalline substrates. Thermal diffusion of niobium from doped substrates into the deposited thin films formed an n(+)-n homojunction, which was profiled by angle-resolved XPS and cross-sectional STEM-EDX techniques...
January 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28063236/reconstruction-of-travel-history-using-coupled-%C3%AE-18-o-and-87-sr-86-sr-measurements-of-hair
#8
Thuan H Chau, Brett J Tipple, Lihai Hu, Diego P Fernandez, Thure E Cerling, James R Ehleringer, Lesley A Chesson
RATIONALE: Oxygen isotope ratios (δ(18) O values) of hair largely reflect features of regional hydrology while strontium isotope ratios ((87) Sr/(86) Sr) are thought to reflect bedrock geology; combination of both isotope signatures may provide greater capacity for determining provenance and reconstructing travel history of an organism. To test this hypothesis, we compared the O-Sr isotope profiles of hair from domestic horses with known residency histories. METHODS: Tail hairs were collected from a pair of horses pastured together for a period of 16 months, one of which lived in a different location for the 8 months prior...
January 7, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28055988/tunable-pyroelectric-properties-of-barium-strontium-titanate-thin-films
#9
Vladimir Shirokov, Anna Razumnaya, Yu Yuzyuk
We studied the influence of the induced strain and applied electric field on the ground state of ferroelectric Ba0.7Sr0.3TiO3 thin films, deposited on the cubic (001) substrate. The dependence of the pyroelectric coefficient on the applied field is calculated for the different values of the induced strain. We found that tuning of the misfit strain in the film under the dielectric bolometer mode by the proper selection of substrate makes it possible to create the structures with very large values of the pyroelectric coefficient...
January 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28054241/characteristic-x-ray-imaging-for-palliative-therapy-using-strontium-89-chloride-understanding-the-mechanism-of-nuclear-medicine-imaging-of-strontium-89-chloride
#10
Yoshiki Owaki, Kazumasa Inoue, Hiroto Narita, Keisuke Tsuda, Masahiro Fukushi
Strontium-89 (Sr-89) chloride is a targeted palliative therapy used for painful bone metastasis in which repeated doses can be administered, and its usefulness has been reported in the case of bone metastasis of various primary tumors. However, the effectiveness of the pain relief treatment is only described using a subjective index such as the visual analog scale, which lacks objectivity. Although various attempts at quantifying the effectiveness of Sr-89 chloride therapy have been reported using nuclear medicine imaging for energy peaks around 70-80 keV, the principle of Sr-89 chloride imaging has not been explained...
January 4, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28052066/effects-of-strontium-ranelate-on-spinal-interbody-fusion-surgery-in-an-osteoporotic-rat-model
#11
Tsung-Ting Tsai, Ching-Lung Tai, Natalie Yi-Ju Ho, Po-Liang Lai, Tsai-Sheng Fu, Chi-Chien Niu, Lih-Huei Chen, Wen-Jer Chen
Osteoporosis is a bone disease that afflicts millions of people around the world, and a variety of spinal integrity issues, such as degenerative spinal stenosis and spondylolisthesis, are frequently concomitant with osteoporosis and are sometimes treated with spinal interbody fusion surgery. Previous studies have demonstrated the efficacy of strontium ranelate (SrR) treatment of osteoporosis in improving bone strength, promoting bone remodeling, and reducing the risk of fractures, but its effects on interbody fusion surgery have not been adequately investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28046816/su-f-p-24-radiological-disperse-device
#12
R Alam
PURPOSE: We are now living in a society of constant fear of terrorism. This topic is pertaining to give a general knowledge of what is a radiological dispersion device or RDD and in case of its detonation, what are the options open to public for a safe action in terms of reducing the exposure and knowing the proper steps. These RDD are also called dirty bombs. METHODS: Compared to nuclear weapons, dirty bombs are easy to make. In order for a terrorist organization to construct and detonate a dirty bomb, it must acquire radioactive material by stealing it or buying it through legal or illegal channels...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040196/aquatic-concentrations-of-chemical-analytes-compared-to-ecotoxicity-estimates
#13
Mitchell S Kostich, Robert W Flick, Angela L Batt, Heath E Mash, J Scott Boone, Edward T Furlong, Dana W Kolpin, Susan T Glassmeyer
We describe screening level estimates of potential aquatic toxicity posed by 227 chemical analytes that were measured in 25 ambient water samples collected as part of a joint USGS/USEPA drinking water plant study. Measured concentrations were compared to biological effect concentration (EC) estimates, including USEPA aquatic life criteria, effective plasma concentrations of pharmaceuticals, published toxicity data summarized in the USEPA ECOTOX database, and chemical structure-based predictions. Potential dietary exposures were estimated using a generic 3-tiered food web accumulation scenario...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28030966/systemic-drugs-that-influence-titanium-implant-osseointegration
#14
Dragos Apostu, Ondine Lucaciu, Gheorghe Dan Osvald Lucaciu, Bogdan Crisan, Liana Crisan, Mihaela Baciut, Florin Onisor, Grigore Baciut, Radu Septimiu Câmpian, Simion Bran
Titanium implants are widely used on an increasing number of patients in orthopedic and dental medicine. Despite the good survival rates of these implants, failures that lead to important socio-economic consequences still exist. Recently, research aimed at improving implant fixation, a process called osseointegration, has focused on a new, inovative field: systemic delivery of drugs. Following implant fixation, patients receive systemic drugs that could either impair or enhance osseointegration; these drugs include anabolic and anti-catabolic bone-acting agents in addition to new treatments...
December 28, 2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28024623/role-of-magnesium-oxide-and-strontium-oxide-as-modifiers-in-silicate-based-bioactive-glasses-effects-on-thermal-behaviour-mechanical-properties-and-in-vitro-bioactivity
#15
Devis Bellucci, Antonella Sola, Roberta Salvatori, Alexandre Anesi, Luigi Chiarini, Valeria Cannillo
The composition of a CaO-rich silicate bioglass (BG_Ca-Mix, in mol%: 2.3 Na2O; 2.3 K2O; 45.6 CaO; 2.6 P2O5; 47.2 SiO2) was modified by replacing a fixed 10mol% of CaO with MgO or SrO or fifty-fifty MgO-SrO. The thermal behaviour of the modified glasses was accurately evaluated via differential thermal analysis (DTA), heating microscopy and direct sintering tests. The presence of MgO and/or SrO didn't interfere with the thermal stability of the parent glass, since all the new glasses remained completely amorphous after sintering (treatment performed at 753°C for the glass with MgO; at 750°C with SrO; at 759°C with MgO and SrO)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024569/strontium-hydroxyapatite-chitosan-nanohybrid-scaffolds-with-enhanced-osteoinductivity-for-bone-tissue-engineering
#16
Yong Lei, Zhengliang Xu, Qinfei Ke, Wenjing Yin, Yixuan Chen, Changqing Zhang, Yaping Guo
For the clinical application of bone tissue engineering with the combination of biomaterials and mesenchymal stem cells (MSCs), bone scaffolds should possess excellent biocompatibility and osteoinductivity to accelerate the repair of bone defects. Herein, strontium hydroxyapatite [SrHAP, Ca10-xSrx(PO4)6(OH)2]/chitosan (CS) nanohybrid scaffolds were fabricated by a freeze-drying method. The SrHAP nanocrystals with the different x values of 0, 1, 5 and 10 are abbreviated to HAP, Sr1HAP, Sr5HAP and Sr10HAP, respectively...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28017868/fabrication-of-amorphous-strontium-polyphosphate-microparticles-that-induce-mineralization-of-bone-cells-in-vitro-and-in-vivo
#17
Werner E G Müller, Emad Tolba, Maximilian Ackermann, Meik Neufurth, Shunfeng Wang, Qingling Feng, Heinz C Schröder, Xiaohong Wang
: Here we describe the fabrication process of amorphous strontium-polyphosphate microparticles ("Sr-a-polyP-MP"). The effects of these particles on growth and gene expression were investigated with SaOS-2 cells as well as with human mesenchymal stem cells (MSC) and compared with those particles prepared of amorphous calcium-polyphosphate ("Ca-a-polyP-MP") and of strontium salt. The results revealed a markedly higher stimulation of growth of MSC by "Sr-a-polyP-MP" compared to "Ca-a-polyP-MP" and a significant increase in mineralization of SaOS-2 cells, as well as an enhanced upregulation of the expression of the genes encoding for alkaline phosphatase and the bone morphogenetic protein 2 (BMP-2), likewise performed with SaOS-2 cells...
December 23, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28011406/bone-as-a-surrogate-tissue-to-monitor-metals-in-baleen-whales
#18
Morgana Vighi, Asunción Borrell, Alex Aguilar
Metals are massively deposited in the marine environment through direct emissions or atmospheric dry and wet depositions, a process since long enhanced by human activities. Metal contamination in the marine organisms has been increasingly investigated, but most research focuses on few tissues, elements and species considered indicative. Baleen whales have been scarcely studied in this respect. Here we contribute to the fragmented knowledge on this field examining the concentrations of zinc, copper, lead, titanium and strontium in the bone of fin whales (Balaenoptera physalus) from NW Spain and W Iceland...
December 9, 2016: Chemosphere
https://www.readbyqxmd.com/read/28008373/clinical-factors-disease-parameters-and-molecular-therapies-affecting-osseointegration-of-orthopedic-implants
#19
Hilal Maradit Kremers, Eric A Lewallen, Andre J van Wijnen, David G Lewallen
Total hip and knee arthroplasty are effective interventions for management of end-stage arthritis. Indeed, about 7 million Americans are currently living with artificial hip and knee joints. The majority of these individuals, however, will outlive their implants and require revision surgeries, mostly due to poor implant osseointegration and aseptic loosening. Revisions are potentially avoidable with better management of patient-related risk factors that affect the osseointegration of orthopedic implants. In this review, we summarize the published clinical literature on the role of demographics, biologic factors, comorbidities, medications and aseptic loosening risk...
September 2016: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/28003842/biomimetic-proopiomelanocortin-suppresses-capsaicin-induced-sensory-irritation-in-humans
#20
Sayed Ali Fatemi, Abbas Jafarian-Dehkordi, Valiollah Hajhashemi, Ali Asilian-Mahabadi
Sensitive skin is a frequently mentioned cosmetic complaint. Addition of a biomimetic of neuromediator has recently appeared as a promising new way to cure skin care product problems. This study was aimed to assess the inhibitory effect of a biomimetic lipopeptide derived from proopiomelanocortin (bPOMC) on capsaicin-induced sensory irritation in human volunteers and also to compare its protective effect with that of the well-known anti irritant strontium chloride. The effect of each test compound was studied on 28 selected healthy volunteers with sensitive skin in accordance with a double-blind vehicle-controlled protocol...
December 2016: Research in Pharmaceutical Sciences
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